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Automated Insulin Delivery in Women With Pregnancy Complicated by Type 1 Diabetes 1 型糖尿病并发妊娠妇女的胰岛素自动输送系统
Pub Date : 2024-04-01 DOI: 10.1097/01.ogx.0001016664.40824.26
Tara T M Lee, Corinne Collett, Simon Bergford, S. Hartnell, Eleanor M Scott, Robert Lindsay, Katharine F. Hunt, D. R. McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Rebecca M. Reynolds, Emma Flanagan, M. Hammond, Lee Shepstone, M. Wilinska, J. Sibayan, C. Kollman, Roy Beck, R. Hovorka, Helen R Murphy
(Abstracted from N Engl J Med 2023;389:1566–1578 Hyperglycemia during pregnancy is an important risk factor for complications, such as preterm birth, large birth weight, and admission to the intensive care unit. Those at highest risk already have glycated hemoglobin above target levels at the start of pregnancy.
(摘自《英国医学杂志》2023;389:1566-1578) 妊娠期高血糖是导致早产、出生体重过大、入住重症监护室等并发症的重要风险因素。风险最高的孕妇在怀孕之初糖化血红蛋白就已超过目标水平。
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引用次数: 0
Randomized Control Trial to Compare Effects of Ultra-Low Dose (Ethinylestradiol 20 μg or 15 μg) With Low Dose (Ethinylestradiol 30 μg) Hormonal Pills on Lipid Discordance in Non-Obese PCOS Women 比较超低剂量(炔雌醇 20 μg 或 15 μg)与低剂量(炔雌醇 30 μg)荷尔蒙药片对非肥胖多囊卵巢综合征女性血脂不协调影响的随机对照试验
Pub Date : 2024-04-01 DOI: 10.1097/ogx.0000000000001264
Subhankar Dasgupta, Joyeeta Mondal, Barnali Goswami, Jija Dasgupta
(Abstracted from Obstet Gynecol Sci 2023;66:572–583 Polycystic ovary syndrome (PCOS) is frequently treated using low-dose hormonal pills with ethinylestradiol (EE) 35 μg combined with progestins for cycle control. Use of these combined oral contraceptives has been associated with metabolic syndrome, dyslipidemia, and a risk of cardiovascular events for women with metabolic disorders.
(摘自 Obstet Gynecol Sci 2023;66:572-583)多囊卵巢综合征(PCOS)经常使用炔雌醇(EE)35 μg 联合孕激素的低剂量激素药片来控制周期。使用这些复方口服避孕药与代谢综合征、血脂异常和患有代谢紊乱的妇女发生心血管事件的风险有关。
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引用次数: 0
A Comparison of Criteria for Defining Metabolic Acidemia in Live-Born Neonates and Its Effect on Predicting Serious Adverse Neonatal Outcomes 活产新生儿代谢性酸中毒定义标准的比较及其对预测新生儿严重不良结局的影响
Pub Date : 2024-04-01 DOI: 10.1097/01.ogx.0001016660.67661.8d
Alexandria C. Kraus, Alexander M Saucedo, John J Byrne, Lina F. Chalak, Jessica E. Pruszynski, Catherine Y. Spong
(Abstracted from Am J Obstet Gynecol 2023;229:439.e1–439.e11 It is common for fetal oxygenation and pH to decline during labor. However, severe oxygen deprivation can cause fetuses to develop metabolic acidemia, a risk factor for moderate to severe neonatal encephalopathy that can progress to cerebral palsy.
(摘自《美国妇产科杂志》2023;229:439.e1-439.e11 分娩过程中胎儿氧合和pH值下降很常见。然而,严重缺氧可导致胎儿出现代谢性酸血症,而代谢性酸血症是导致中度至重度新生儿脑病的危险因素,可发展为脑瘫。
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引用次数: 0
Screening for Critical Congenital Heart Defects in Sweden 瑞典先天性心脏病筛查
Pub Date : 2024-04-01 DOI: 10.1097/ogx.0000000000001268
K. Lannering, Kalliopi Kazamia, Gunnar Bergman, Ingegerd Östman-Smith, P. Liuba, J. Dahlqvist, Anders Elfvin, Mats Mellander
(Abstracted from Pediatrics 2023;152:e2023061949 Critical congenital heart defects (CCHDs) affect between 1 and 3 of every 1000 live-born infants and require intervention in the short term after birth. Early identification of affected infants contributes to significantly to better outcomes in both the short- and long-term.
(摘自《儿科学》2023;152:e2023061949) 严重先天性心脏缺陷(CCHD)影响着每 1000 个活产婴儿中的 1 到 3 个,需要在出生后短期内进行干预。及早发现受影响的婴儿可大大改善短期和长期的预后。
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引用次数: 0
Patient Preferences for Disposable and Reusable Vaginal Specula and Their Willingness to Compromise in the Era of Climate Change: A Cross-Sectional Study 气候变化时代患者对一次性阴道窥器和可重复使用阴道窥器的偏好及其妥协意愿:一项横断面研究
Pub Date : 2024-04-01 DOI: 10.1097/ogx.0000000000001266
Amber A A Ten Buuren, Tessa B. Poolman, Lauren M. Bullens, N. van Hanegem, Marlies Y. Bongers, Wenche M. Klerkx, Anne Timmermans, N. P. A. Zuithoff, Anneke Kwee
(Abstracted from BJOG. 2024;131:684–689 The World Health Organization emphasizes that the climate crisis is the single biggest health threat facing humanity, and more than 200 medical journals have called on world leaders to take more and faster action against climate change. Despite this, hospitals have increasingly relied on disposable instruments such as plastic specula, which are incinerated after a single use.
(摘自 BJOG.2024;131:684-689 世界卫生组织强调,气候危机是人类面临的最大健康威胁,200 多份医学期刊呼吁世界各国领导人采取更多、更快的行动应对气候变化。尽管如此,医院还是越来越依赖塑料窥器等一次性器械,这些器械使用一次后就会被焚毁。
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引用次数: 0
First Babies Conceived With Automated Intracytoplasmic Sperm Injection 首批采用卵胞浆内自动精子注射技术受孕的婴儿
Pub Date : 2024-04-01 DOI: 10.1097/01.ogx.0001016700.92425.05
N. Costa-Borges, Santiago Munne, Eduard Albó, Sergio Mas, Carolina Castello, Guillem Giralt, Zhuo Lu, Charles Chau, M. Acacio, E. Mestres, Queralt Matia, L. Marquès, Mariona Rius, Carmen Marquez, I. Vanrell, Aïda Pujol, D. Mataró, Michelle Seth-Smith, L. Mollinedo, Gloria Calderon, John Zhang
(Abstracted from Reprod Biomed Online 2023;47:103237 Intracytoplasmic sperm injection (ICSI) is a common procedure used in approximately 70% of in vitro fertilization (IVF) cycles. The procedure involves using glass micropipettes to penetrate the oolemma and injection of sperm into the oocyte.
(摘自 Reprod Biomed Online 2023;47:103237)卵胞浆内精子注射(ICSI)是体外受精(IVF)周期中约 70% 的常用程序。该过程包括使用玻璃微管穿透卵母细胞,将精子注入卵母细胞。
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引用次数: 0
The Efficacy, Safety, and Tolerability of an Estrogen-Free Oral Contraceptive Drospirenone 4 mg (24/4-Day Regimen) in Obese Users 不含雌激素的口服避孕药屈螺酮 4 毫克(24/4 天疗法)对肥胖者的疗效、安全性和耐受性研究
Pub Date : 2024-04-01 DOI: 10.1097/01.ogx.0001016688.86364.3f
M. D. Creinin, Alicyoy Angulo, Enrico Colli, David F. Archer
(Abstracted from Contraception 2023;128:1–7 There is a lack of data regarding the safety and efficacy of oral contraceptives in people with a body mass index (BMI) over 35. Drospirenone 4 mg is a new progestogen-only contraceptive pill that is taken in a 24 + 4 pattern, with 24 hormonal and 4 placebo pills.
(摘自《避孕》2023;128:1-7) 目前缺乏有关体重指数(BMI)超过 35 的人群口服避孕药安全性和有效性的数据。屈螺酮 4 毫克是一种新型的纯孕激素避孕药,以 24+4 的模式服用,其中包括 24 片激素药片和 4 片安慰剂药片。
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引用次数: 0
Top Advances of the Year: Ovarian Cancer 年度最佳进展:卵巢癌
Pub Date : 2024-04-01 DOI: 10.1097/01.ogx.0001016696.16905.e0
M. Lumish, Elise C. Kohn, William P. Tew
(Abstracted from Cancer 2024;130:837–845 Although novel systemic therapies have prolonged survival in ovarian cancer, it remains the fifth leading cause of cancer-related death in women. In 2022, data showing an overall survival (OS) benefit from poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) were published after a 7-year follow-up period.
(摘自《癌症》2024;130:837-845 虽然新型系统疗法延长了卵巢癌患者的生存期,但它仍是女性癌症相关死亡的第五大原因。2022年,一项为期7年的随访数据显示,聚(ADP-核糖)聚合酶(PARP)抑制剂(PARPi)可提高总生存率(OS)。
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引用次数: 0
Postnatal Genetic and Neurodevelopmental Assessment in Infants Born at Term With Severely Low Birth Weight of Non-placental Origin 非胎盘源性严重出生体重不足足月新生儿的产后遗传和神经发育评估
Pub Date : 2024-03-01 DOI: 10.1097/01.ogx.0001010420.53414.ec
M. F. Paz y Miño, M. Pauta, E. Meler, I. Matas, E. Mazarico, A. Camacho, M. Segura, F. Figueras, A. Borrell
Small for gestational age (SGA) newborns are generally defined as those with a birth weight below the 10th percentile. Fetuses diagnosed with fetal growth restriction (FGR) are usually evaluated to determine if there is a pathological cause and thus a higher risk for adverse outcomes due to being small. Often when this diagnosis is made early in the third trimester, chromosomal microarray analysis is recommended to detect genetic disease. This study was designed to determine the frequency of monogenic disorders in term infants with severely low birth weight but normal Doppler results, as well as to estimate the frequency of neurodevelopmental impairment when a genetic etiology was ruled out. Inclusion criteria for this study were singleton pregnancy; term delivery; birth weight more than 2.5 SDs below the mean; normal Doppler studies of the umbilical artery, fetal middle cerebral artery, cerebroplacental ratio, and uterine artery; no maternal hypertensive disease; and no prenatal fetal structural or identified genetic anomalies or fetal infection. Exclusion criteria included incomplete data. Exome sequencing was completed using saliva sampling and blood sampling, and standard neurodevelopmental assessment techniques were used for children 2 to 3.5 and 6 to 8 years old. Children aged between 3.5 and 6 years were not included because of lack of standardized neurodevelopmental testing. A total of 63 families were contacted, and 7 (11%) reported that a genetic disorder had been diagnosed after birth. In addition, 18 individuals without a known genetic disorder who met all the criteria underwent exome sequencing and neurodevelopmental testing. Of the 7 who reported a postnatally diagnosed genetic syndrome, 5 were Mendelian monogenetic and 2 were epigenetic, including Cockayne syndrome; short stature, microcephaly, and endocrine dysfunction syndrome; Renpenning syndrome; Noonan syndrome; Russell-Silver syndrome; and Prader-Willi syndrome. Median birth weight among the children with genetic disorders was not different from children without. Exome sequencing was normal in the 18 children who were tested and who had not been previously diagnosed with a genetic syndrome. None of the children showed less than average neurodevelopment on overall assessment in the lower age group. In the higher age group, 2 children were classified as having low IQ, with one borderline and one extremely low, with low scores in all other domains as well. In addition, 6 individuals showed a low score in at least 1 of the 5 domains, with the largest deviations showing in the domains of verbal comprehension and working memory. Clinicians should be aware of the potential outcomes of FGR even when other complications are not present. Counseling about genetic analysis prenatally or within a short postnatal timeframe could save a lot of time and effort in evaluating children later. In addition, children should be carefully assessed in later childhood for neurodevelopmental diff
胎龄小新生儿(SGA)一般指出生体重低于第 10 百分位数的新生儿。被诊断为胎儿生长受限(FGR)的胎儿通常要进行评估,以确定是否存在病理原因,从而确定胎儿过小导致不良后果的风险较高。通常在妊娠三个月早期做出诊断时,建议进行染色体微阵列分析以检测遗传疾病。本研究旨在确定出生体重严重偏低但多普勒结果正常的足月婴儿中单基因疾病的发生率,以及在排除遗传病因的情况下神经发育障碍的发生率。这项研究的纳入标准是:单胎妊娠;足月分娩;出生体重低于平均值 2.5 SDs 以上;脐动脉、胎儿大脑中动脉、脑-胎盘比例和子宫动脉的多普勒检查结果正常;母体无高血压疾病;产前胎儿无结构异常或已确定的遗传异常或胎儿感染。排除标准包括数据不完整。外显子组测序是通过唾液采样和血液采样完成的,对2至3.5岁和6至8岁的儿童采用了标准的神经发育评估技术。由于缺乏标准化的神经发育测试,3.5至6岁的儿童未被纳入。共联系了 63 个家庭,其中有 7 个家庭(11%)报告说他们在出生后被诊断出患有遗传性疾病。此外,18 名没有已知遗传疾病但符合所有标准的个体接受了外显子组测序和神经发育测试。在报告产后诊断出遗传综合征的 7 人中,5 人是孟德尔单基因遗传,2 人是表观遗传,包括科凯恩综合征;身材矮小、小头畸形和内分泌功能障碍综合征;伦彭宁综合征;努南综合征;拉塞尔-希尔弗综合征和普拉德-威利综合征。遗传疾病患儿的出生体重中位数与非遗传疾病患儿没有差异。在接受检测的 18 名儿童中,外显子组测序结果正常,他们之前未被诊断出患有遗传综合征。在低年龄组的总体评估中,没有一名儿童的神经发育低于平均水平。在高年龄组中,有两名儿童被归类为低智商,其中一名为边缘低智商,另一名为极低智商,而且在所有其他领域的得分也很低。此外,6 名儿童在 5 个领域中至少有 1 个领域得分偏低,偏差最大的领域是言语理解和工作记忆。即使没有其他并发症,临床医生也应了解 FGR 的潜在后果。在产前或产后短时间内提供有关遗传分析的咨询,可以为日后评估患儿节省大量的时间和精力。此外,在儿童后期应仔细评估儿童的神经发育差异,这些差异是可以治疗的,或者可能需要不同的资源。未来的研究应侧重于进一步使人群同质化,以获得更准确的结果,并处理本研究中可能存在的偏差。
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引用次数: 0
Fetal Surveillance From 39 Weeks’ Gestation to Reduce Stillbirth in South Asian–Born Women 从妊娠 39 周开始进行胎儿监测以减少南亚裔妇女的死胎率
Pub Date : 2024-03-01 DOI: 10.1097/ogx.0000000000001256
Miranda L. Davies-Tuck, Mary-Ann Davey, Ryan L. Hodges, Euan M. Wallace
Women of South Asian background are known to have higher rates of stillbirth than women in other high-income countries, such as Australia or the United Kingdom. To reduce the rate of stillbirth, leading societies recommend antenatal fetal monitoring or induction of labor (IOL) at 41 weeks of gestation regardless of race/ethnicity. However, at 41 weeks' gestation, the risk of stillbirth for South Asian–born women is already up to 5 times higher than for Australian-born women. Initially, the UK National Institution for Health and Care Excellence recommended that all South Asian women undergo IOL earlier, at 39 weeks of gestation. However, this recommendation was criticized as being racist, and perpetuating the myth that race plays a factor in poor outcomes, so it was amended to state that South Asian–born women might benefit from additional monitoring and support. Still, there is no evidence to support this guidance. In July 2017, the State of Victoria in Australia implemented a new clinical guideline to provide South Asian women with biweekly cardiotocography and amniotic fluid measurement at 39 weeks of gestation. The aim of this study was to assess the impact of the new clinical guideline on the rates of stillbirth and select pregnancy outcomes for South Asian women. This was a cohort study that included women with singleton pregnancies who gave birth at term or beyond at a university- affiliated teaching health service located in 3 metropolitan areas in Australia from January 1, 2016, to December 31, 2020. Women were classified as South Asian born if they self-identified as being from Afghanistan, Bangladesh, Bhutan, India, Iran, the Maldives, Nepal, Pakistan, or Sri Lanka. The timeframe between January 1, 2016, and June 30, 2017, represented the period before the change in practice for fetal monitoring for South Asian women; the timeframe between July 1, 2017, and December 31, 2020, represented the period after. Although the new practice was applied to South Asian–born women in the second timeframe, fetal monitoring at 41 weeks was applied to all other women. The primary outcome was stillbirth at the onset of or during labor at 37 weeks and 39 weeks of gestation. The secondary outcomes included neonatal death at <7 days, admission to the special care nursery or neonatal intensive care, Apgar score <7 at 5 minutes, infant birthweight, gestation of birth, IOL, and mode of birth. A total of 3506 South Asian women gave birth before the change in practice, whereas 8532 gave birth postimplementation. The rate of stillbirth at 37 weeks' gestation for South Asian–born women was 2.3 per 1000 births—a 2.6-fold higher rate than for other women (0.9 per 1000 births; P = 0.06). After the change in practice, the rate of stillbirth fell by 64% for South Asian–born women (95% confidence interval, 87%–2%; P = 0.047). The association was stronger when the results were restricted to births after 39 weeks of gestation. Also, after the change in practice, redu
众所周知,与澳大利亚或英国等其他高收入国家的妇女相比,南亚裔妇女的死胎率更高。为了降低死胎率,主要学会都建议在妊娠 41 周时进行产前胎儿监护或引产(IOL),而不考虑种族/民族。然而,在妊娠 41 周时,南亚出生妇女的死胎风险已经比澳大利亚出生妇女高出 5 倍。最初,英国国家健康与护理卓越研究所建议所有南亚妇女在妊娠 39 周时提前进行人工晶体植入术。然而,这一建议被批评为带有种族主义色彩,延续了 "种族是导致不良后果的一个因素 "的神话,因此,该建议被修改为:南亚出生的妇女可能会从额外的监测和支持中获益。尽管如此,仍没有证据支持这一指导意见。2017 年 7 月,澳大利亚维多利亚州实施了一项新的临床指南,规定南亚裔妇女在妊娠 39 周时每两周进行一次心脏排卵造影和羊水测量。本研究旨在评估新临床指南对南亚裔妇女死胎率和特定妊娠结局的影响。这是一项队列研究,研究对象包括2016年1月1日至2020年12月31日期间在澳大利亚3个大都会地区的大学附属教学医疗服务机构分娩的足月或足月以上的单胎妊娠妇女。如果妇女自我认同来自阿富汗、孟加拉国、不丹、印度、伊朗、马尔代夫、尼泊尔、巴基斯坦或斯里兰卡,则被归类为南亚出生的妇女。2016 年 1 月 1 日至 2017 年 6 月 30 日为南亚妇女胎儿监护实践改变前的时间段;2017 年 7 月 1 日至 2020 年 12 月 31 日为改变后的时间段。虽然在第二个时间框架内,新的做法适用于南亚出生的妇女,但41周时的胎儿监测适用于所有其他妇女。主要结果是妊娠 37 周和 39 周开始分娩时或分娩过程中的死产。次要结果包括新生儿死亡时间小于 7 天、入住特殊护理室或新生儿重症监护室、5 分钟内阿普加评分小于 7 分、婴儿出生体重、妊娠期、IOL 和分娩方式。在改变做法之前,共有 3506 名南亚妇女分娩,而在实施后则有 8532 名妇女分娩。南亚裔产妇在妊娠 37 周时的死胎率为 2.3‰,是其他产妇的 2.6 倍(0.9‰;P = 0.06)。改变做法后,南亚裔妇女的死胎率下降了 64%(95% 置信区间,87%-2%;P = 0.047)。当结果仅限于妊娠 39 周后的分娩时,这种关联性更强。此外,在改变做法后,新生儿早期死亡率(3.1%.vs 1.3%.;P = 0.03)和入住特殊护理育婴室的比率(16.5% vs 11.1%;P < 0.001)也有所降低。实施前,南亚裔妇女的妊娠期中位数为 39+3 周,实施后为 39+2 周,相差 1 天。南亚裔妇女的 IOL 发生率比其他妇女高 4.9%(95% 置信区间,1.3%-8.5%;P = 0.008)。然而,在改变做法后,两组妇女每月的 IOL 发生率以及其他次要结果均无明显差异。总之,与之前在妊娠41周时开始监测胎儿的指南相比,南亚裔产妇在妊娠39周时开始监测胎儿可降低死胎率、新生儿死亡率和入住特殊护理托儿所的比率。
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引用次数: 0
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Obstetrical &amp; Gynecological Survey
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