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Heparin for Women With Recurrent Miscarriage and Inherited Thrombophilia (ALIFE2): An International Open-Label, Randomised Controlled Trial 肝素治疗复发性流产和遗传性血栓性妇女(ALIFE2):一项国际开放标签随机对照试验
Pub Date : 2024-01-01 DOI: 10.1097/01.ogx.0001006880.59476.45
S. Quenby, Katie Booth, Louise Hiller, A. Coomarasamy, Paulien G. de Jong, Eva N. Hamulyák, L. Scheres, T. V. van Haaps, L. Ewington, Shreeya Tewary, M. Goddijn, Saskia Middeldorp
(Abstracted from Lancet 2023;402:54–61) Inherited thrombophilia is implicated as a cause of recurrent pregnancy loss, defined as the loss of 2 or more pregnancies. Heparin is the standard treatment for acquired thrombophilia but is not recommended in cases of recurrent pregnancy loss and inherited thrombophilia.
(摘自《柳叶刀》2023;402:54-61)遗传性血栓性疾病是导致反复妊娠流产的原因之一,反复妊娠流产是指两次或两次以上妊娠流产。肝素是治疗获得性血栓性疾病的标准药物,但不推荐用于反复妊娠流产和遗传性血栓性疾病。
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引用次数: 0
Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage 产后出血早期检测和治疗随机试验
Pub Date : 2024-01-01 DOI: 10.1097/01.ogx.0001006884.97006.bc
I. Gallos, A. Devall, J. Martin, L. Middleton, L. Beeson, H. Galadanci, F. A. Al-beity, Z. Qureshi, G. J. Hofmeyr, N. Moran, S. Fawcus, L. Sheikh, G. Gwako, A. Osoti, A. Aswat, Kristie-Marie Mammoliti, K. N. Sindhu, M. Podesek, I. Horne, R. Timms, I. Yunas, J. Okore, M. Singata-Madliki, E. Arends, A. A. Wakili, A. Mwampashi, S. Nausheen, S. Muhammad, P. Latthe, C. Evans, S. Akter, G. Forbes, D. Lissauer, S. Meher, A. Weeks, A. Shennan, A. Ammerdorffer, E. Williams, T. Roberts, M. Widmer, O. Oladapo, F. Lorencatto, M. A. Bohren, S. Miller, F. Althabe, M. Gülmezoglu, J. M. Smith, K. Hemming, A. Coomarasamy
(Abstracted from N Engl J Med 2023;389:11–21) Postpartum hemorrhage (PPH) is a serious complication of childbirth, and delays in diagnosis and treatment can cause major complications or fatalities. One method of early detection is a blood-collection drape, possibly in conjunction with other tests and treatments.
(摘自《英国医学杂志》2023;389:11-21)产后出血(PPH)是一种严重的分娩并发症,延误诊断和治疗可导致重大并发症或死亡。早期检测的方法之一是使用采血帘,并可能结合其他检查和治疗。
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引用次数: 0
Penetrance of Pathogenic Genetic Variants Associated With Premature Ovarian Insufficiency 与卵巢早衰有关的致病基因变异的发生率
Pub Date : 2024-01-01 DOI: 10.1097/ogx.0000000000001240
S. Shekari, Stasa Stankovic, Eugene J. Gardner, G. Hawkes, K. Kentistou, R. Beaumont, A. Mörseburg, Andrew R. Wood, Julia K. Prague, Gita D. Mishra, F. Day, Julia Baptista, Caroline F. Wright, M. Weedon, Eva R. Hoffmann, K. Ruth, Ken K. Ong, John R. B. Perry, Anna Murray
(Abstracted from Nat Med 2023;29:1692–1699) Premature ovarian insufficiency (POI), defined as the loss of ovarian activity and permanent cessation of menstruation occurring before age 40 years, affects 1% of women and is a leading cause of infertility. Up to 90% of POI cases are idiopathic, with up to 30% of those having some familial association, suggesting a genetic basis.
(摘自《自然医学》2023;29:1692-1699)早发性卵巢功能不全(Premature ovarian insufficiency,POI)是指在 40 岁之前发生的卵巢活动丧失和月经永久停止,影响 1%的女性,是导致不孕的主要原因之一。多达 90% 的卵巢功能不全病例是特发性的,其中多达 30% 的病例与家族遗传有关,这表明该病有遗传基础。
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引用次数: 0
The Association of Federal Medicaid Abortion Funding Restrictions With Adverse Obstetric Outcomes Among United States Medicaid Recipients 联邦医疗补助计划堕胎资金限制与美国医疗补助计划受助者不良产科结果的关系
Pub Date : 2024-01-01 DOI: 10.1097/ogx.0000000000001236
Maria I. Rodriguez, T. Meath, Ashley Daly, K. Watson, K. McConnell
(Abstracted from Contraception 2023;126:110116) Obstetric care in the United States is predominantly paid for by Medicaid, which covers nearly half of all births. An essential component of comprehensive obstetric care is legal, safe abortion, and restricted access to such procedures is related to increased maternal mortality and morbidity.
(摘自《避孕 2023;126:110116》)美国的产科护理主要由医疗补助计划支付费用,该计划覆盖了近一半的新生儿。合法、安全的人工流产是全面产科护理的重要组成部分,限制获得此类手术与孕产妇死亡率和发病率的增加有关。
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引用次数: 0
Reproductive Outcomes of Oocyte Donation in Patients With Uterine Mullerian Anomalies 子宫穆勒氏管异常患者捐献卵母细胞的生殖结果
Pub Date : 2024-01-01 DOI: 10.1097/01.ogx.0001006920.69365.09
E. Muñoz, I. Fernandez, N. Pellicer, Giulia Mariani, Antonio Pellicer, Nicolás Garrido
(Abstracted from Fertil Steril 2023;120(4):850–859) Uterine müllerian anomalies (UMAs) are anatomic malformations of the female genital tract found in 5.5% of the general population but 24.5% of women with a history of miscarriage and infertility. Studies identifying the relationships between UMAs and reproductive outcomes suggest a higher rate of adverse outcomes but have largely been conducted in women using their own oocytes and have focused on a single anomaly category.
(摘自Fertil Steril 2023;120(4):850-859)子宫缪勒管畸形(UMAs)是女性生殖道的解剖畸形,在普通人群中占5.5%,但在有流产和不孕史的女性中占24.5%。有关 UMAs 与生殖结果之间关系的研究表明,UMAs 的不良结果发生率较高,但这些研究主要是针对使用自身卵母细胞的妇女进行的,而且只关注单一的异常类别。
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引用次数: 0
CME PROGRAM EXAM AND ANSWER SHEET CME 项目考试和答卷
Pub Date : 2024-01-01 DOI: 10.1097/ogx.0000000000001249
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引用次数: 0
Trends in State-Level Maternal Mortality by Racial and Ethnic Group in the United States 美国各州按种族和族裔群体分列的孕产妇死亡率趋势
Pub Date : 2024-01-01 DOI: 10.1097/01.ogx.0001006900.72471.28
Laura G Fleszar, Allison S. Bryant, Catherine O. Johnson, B. Blacker, Aleksandr Aravkin, Mathew Baumann, L. Dwyer-Lindgren, Yekaterina O. Kelly, Kelsey Maass, Peng Zheng, Gregory A Roth
(Abstracted from JAMA 2023;330(1):52–61) Recent evidence shows that maternal mortality is higher in the United States than any high-income country and that it is increasing. Previous research on this topic has been limited by inconsistent terminology, definitions, and methods.
(摘自《美国医学会杂志》2023;330(1):52-61)最近的证据表明,美国的孕产妇死亡率高于任何高收入国家,而且还在不断上升。由于术语、定义和方法不一致,以往对这一主题的研究受到了限制。
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引用次数: 0
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Obstetrical & Gynecological Survey
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