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IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00579-6

引用次数: 0

Corrigendum to “HIV-Related Atherosclerosis: State-of-the-Art-Review” [Current Problems in Cardiology, Volume 48, Issue 9, September 2023, 101783] 与艾滋病毒相关的动脉粥样硬化：最新进展综述》[《心脏病学当前问题》，第 48 卷第 9 期，2023 年 9 月，101783] 更正

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-26 DOI: 10.1016/j.cpcardiol.2024.102928

Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Olga Urazova , Artem Trofimenko , Grizelda Navarsdyan , Zinaida Jndoyan , Kristina Abgaryan , Federica Fogacci , Mattia Galli , Luciano Agati , Zhanna Kobalava , Davood Shafie , Mario Marzilli , Liana Gogiashvili , Nizal Sarrafzadegan

引用次数: 0

Association between polysocial risk score and CVH among women of reproductive age in the SAFE HEART study: An American Heart Association Research Goes Red Initiative SAFE HEART 研究中育龄妇女的多社会风险评分与心血管健康之间的关系：美国心脏协会 "红色研究计划"："育龄妇女的多社会风险与心血管健康"。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-25 DOI: 10.1016/j.cpcardiol.2024.102947

Faith E. Metlock PhD(c), RN , Yaa Adoma Kwapong MD, MPH , Dhananjay Vaidya M.B.B.S., Ph.D., MPH , Ketum Ateh Stanislas MD, MPH , Zulqarnain Javed PhD, MBBS, MPH , Pamela S. Douglas MD , Khurram Nasir MD MS , Crystal Evans MS , Roxanne Mirabal-Beltran PhD, RN , Asma Rayani M.B.B.S, Sc.M , Pamela Ouyang M.B.B.S., FACC, FAHA , Yvonne Commodore-Mensah PhD, MHS, RN , Garima Sharma MD

Background

To assess the association between polysocial risk factors and cardiovascular health (CVH) among women of reproductive age.

Methods

Our cross-sectional analysis included women of reproductive age (18–44 years) from community settings and the American Heart Association's Research Goes Red (RGR) registry. Polysocial risk scores (0–14) reflected social disadvantage across domains including socioeconomic stability (education, employment, income, insurance, financial strain), living situation (housing stability, housing quality, marital status, home ownership), food security, transportation, utilities, and interpersonal safety. Suboptimal CVH was defined as having ≥2 risk factors from Life's Essential 8 metrics: physical activity, diet, body mass index, sleep, smoking, blood pressure, blood sugar, and cholesterol. Associations between polysocial risk and suboptimal CVH were analyzed using linear regression models

Results

Suboptimal CVH increased with higher polysocial risk, from 77.0 % in the lowest quartile to 95.2 % in the highest. Participants in quartile 3 had the highest odds of suboptimal CVH (aOR 9.52, 95 % CI 2.63–34.46), while quartile 4 showed decreased but significant odds (aOR 3.86, 95 % CI 1.03–14.40) compared to quartile 1. Hypertension (aOR 10.23, 95 % CI 3.61–29.01), diabetes (aOR 8.87, 95 % CI 3.12–25.24), hyperlipidemia (aOR 7.48, 95 % CI 2.72–20.55), and smoking (aOR 9.46, 95 % CI 3.25–27.56) were strongly associated with higher polysocial risk in community-enrolled participants, whereas trends were less consistent in RGR-enrolled participants.

Conclusions

Women with higher social risks face greater odds of suboptimal CVH. Screening for social determinants and tailored public health interventions are essential for mitigating CVH risks in this population.

背景：评估育龄妇女的多重社会风险因素与心血管健康（CVH）之间的关系：评估育龄妇女的多重社会风险因素与心血管健康（CVH）之间的关系：我们的横断面分析包括来自社区环境和美国心脏协会 "红色研究"（RGR）登记处的育龄妇女（18-44 岁）。多社会风险评分（0-14 分）反映了各个领域的社会不利条件，包括社会经济稳定性（教育、就业、收入、保险、经济压力）、生活状况（住房稳定性、住房质量、婚姻状况、住房所有权）、食品安全、交通、公用事业和人际安全。在 "生活必备 8 项指标"（体育锻炼、饮食、体重指数、睡眠、吸烟、血压、血糖和胆固醇）中，有≥2 项风险因素的人被定义为 "次优 CVH"。使用线性回归模型分析了多重社会风险与次优 CVH 之间的关系结果：次优 CVH 随多重社会风险的增加而增加，从最低四分位数的 77.0% 增加到最高四分位数的 95.2%。与四分位数 1 相比，四分位数 3 的参与者发生次优 CVH 的几率最高（aOR 9.52，95% CI 2.63-34.46），而四分位数 4 的几率有所下降，但仍很显著（aOR 3.86，95% CI 1.03-14.40）。在社区登记的参与者中，高血压（aOR 10.23，95% CI 3.61-29.01）、糖尿病（aOR 8.87，95% CI 3.12-25.24）、高脂血症（aOR 7.48，95% CI 2.72-20.55）和吸烟（aOR 9.46，95% CI 3.25-27.56）与较高的多重社会风险密切相关，而在 RGR 登记的参与者中，趋势不太一致：结论：社会风险较高的妇女面临次优 CVH 的几率更大。社会决定因素筛查和有针对性的公共卫生干预对于降低这一人群的 CVH 风险至关重要。

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引用次数: 0

Prevalence and outcomes of concomitant cardiac amyloidosis and coronary artery disease 心脏淀粉样变性和冠状动脉疾病并发症的发病率和预后。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-24 DOI: 10.1016/j.cpcardiol.2024.102932

Koyenum Obi MD , Sahil Bharwani DO MPH , Vince Catalfamo MD , Antonio Duran MD , Harith Baldawi MD , Connor Gillies DO , Senthil Anand MBBS , James Wever-Pinzon MD , Clement Eiswirth MD , Sapna Desai MD , Selim Krim MD

Background

Cardiac amyloidosis (CA) and coronary artery disease (CAD) can have similar presentations in the acute care setting which can potentially delay the diagnosis of CA.

Methods

We conducted a retrospective analysis of patients referred to our institution for evaluation of cardiac amyloidosis. We obtained demographic and clinical characteristics, laboratory data, and echocardiographic measurements of those patients with confirmed cardiac amyloidosis. The population was divided into two groups based on the presence of CAD. Frequency of heart failure hospitalizations, and one-year overall mortality were compared between both groups.

Results

Between 2018 to 2021, 327 patients with suspected cardiac amyloidosis were referred to our institution. Out of 114 confirmed CA patients, 28 patients (25%) had concomitant CAD and CA. The overall mean age of CA diagnosis was 74.7 (±8.4) years for the CAD group and 69.7 (±9.8) for the non-CAD group (P value 0.002). Notably, a higher percentage of males were observed in the CAD group (92/.9% vs. 60%, p-value 0.002), and a higher prevalence of hypertension (92.9% vs 70%, p-value 0.018) and dyslipidemia (89.3% vs 59%, p-value 0.004) were also found in the CAD group. Overall, there were no significant differences in outcomes.

Conclusion

Larger studies are needed to identify characteristics that will result in a prompt diagnosis of CA in patients with concomitant CAD. Although our study did not appreciate a significant difference between these two groups, outcomes of our study were likely impacted by a small sample size in the CA with CAD cohort.

背景：心脏淀粉样变性（CA）和冠状动脉疾病（CAD）在急诊中的表现相似，可能会延误CA的诊断：心脏淀粉样变性（CA）和冠状动脉疾病（CAD）在急性期的表现相似，这可能会延误CA的诊断：我们对转诊至本机构评估心脏淀粉样变性的患者进行了回顾性分析。我们获得了确诊为心脏淀粉样变性患者的人口统计学特征、临床特征、实验室数据和超声心动图测量结果。根据是否患有 CAD 将患者分为两组。比较两组患者的心力衰竭住院频率和一年总死亡率：2018年至2021年间，327名疑似心脏淀粉样变性患者转诊至我院。在114名确诊的CA患者中，28名患者（25%）同时患有CAD和CA。CAD组确诊CA的总平均年龄为74.7（±8.4）岁，非CAD组为69.7（±9.8）岁（P值0.002）。值得注意的是，CAD 组中男性比例较高（92/.9% 对 60%，P 值 0.002），高血压（92.9% 对 70%，P 值 0.018）和血脂异常（89.3% 对 59%，P 值 0.004）发生率也较高。总体而言，结果无明显差异（表 1）：结论：需要进行更大规模的研究，以确定哪些特征可使合并有 CAD 的患者被及时诊断为 CA。虽然我们的研究没有发现这两组患者之间存在显著差异，但我们的研究结果可能会受到伴有 CAD 的 CA 组样本量较小的影响。

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引用次数: 0

Temporal trends and disparities in atherosclerosis-associated cerebrovascular disease mortality in the United States, 1999-2020 1999-2020 年美国动脉粥样硬化相关脑血管疾病死亡率趋势的逆转。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-24 DOI: 10.1016/j.cpcardiol.2024.102935

Huzaifa Ul Haq Ansari MBBS , Eman Mahboob MBBS , Muhammad Ammar Samad MBBS , Maryam Shahzad MBBS , Mushood Ahmed MBBS , Syed Tabeer Hussain Naqvi MBBS , Shurjeel Uddin Qazi MBBS , Faizan Ahmed MD , Hollie Ross-Kenny MBBS , Muath Baniowda MD , Hina Farrukh MD , Raheel Ahmed

Background

Cerebrovascular disease (CEVD) accounts for the second leading cause of death worldwide. Despite recent advancements in treatment strategies, the prevalence and cost associated with CEVD are rising. Atherosclerosis significantly contributes to CEVD risk by restricting cerebral blood flow, leading to ischemic stroke. This study aims to analyze trends in atherosclerosis-associated CEVD mortality in the United States from 1999 to 2020 to inform targeted prevention and management strategies.

Methods

We examined death certificates sourced from the CDC WONDER database, from 1999 to 2020 to identify atherosclerosis-associated CEVD mortality. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent changes were reported.

Results

A total of 325,401 deaths occurred from CEVD among adults with atherosclerosis from 1999 to 2020 in the US. The overall AAMR initially inclined from 10.9 in 1999 to 12.6 in 2001, followed by a decrease to 4.2 in 2016, and then a rise till 2020 was observed. Males had consistently higher AAMRs than females throughout the study period (Men = 11.9 vs Women = 10.1). When stratified by race, AAMRs were highest among non-Hispanic (NH) Whites (6.9), followed by NH American Indian/Alaska Native (10.9), NH Blacks/African Americans (6.6), Hispanics (4.9), and lastly by Asian/Pacific Islanders (4.2). The Western region had the highest mortality (AAMR: 7.7).

Conclusion

The CEVD mortality rates of adults with atherosclerosis- are increasing in the adult U.S. population. This underscores the need for increased screening, aggressive management, and subsequent surveillance of patients at risk.

背景：脑血管疾病（CEVD）是全球第二大死亡原因。尽管最近在治疗策略方面取得了进展，但与脑血管病相关的发病率和费用仍在上升。动脉粥样硬化会限制脑血流，导致缺血性中风，从而大大增加脑血管疾病的风险。本研究旨在分析 1999 年至 2020 年美国动脉粥样硬化相关 CEVD 的死亡率趋势，为有针对性的预防和管理策略提供依据：方法：我们检查了来自美国疾病预防控制中心 WONDER 数据库的 1999 年至 2020 年死亡证明，以确定与动脉粥样硬化相关的 CEVD 死亡率。报告了每 10 万人的年龄调整死亡率（AAMRs）和每年的百分比变化：结果：1999 年至 2020 年，美国患有动脉粥样硬化的成年人中，共有 325,401 人死于 CEVD。总体AAMR最初从1999年的10.9上升到2001年的12.6，随后下降到2016年的4.2，然后一直上升到2020年。在整个研究期间，男性的 AAMR 始终高于女性（男性 = 11.9 vs 女性 = 10.1）。按种族分层时，非西班牙裔（NH）白人的急性心肌梗死死亡率最高（6.9），其次是 NH 美洲印第安人/阿拉斯加原住民（10.9）、NH 黑人/非洲裔美国人（6.6）、西班牙裔（4.9），最后是亚裔/太平洋岛民（4.2）。西部地区的死亡率最高（AAMR：7.7）：结论：在美国成年人口中，患有动脉粥样硬化的成年人的 CEVD 死亡率正在上升：结论：在美国成年人群中，动脉粥样硬化成人患者的 CEVD 死亡率正在上升：这强调了对高危患者加强筛查、积极管理和后续监测的必要性。

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引用次数: 0

Advancements, challenges, and innovative strategies in cardiac rehabilitation for patients with acute myocardial infarction: A systematic review 急性心肌梗死患者心脏康复的进展、挑战和创新策略：系统综述。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102934

Sisheng Zhang, Yuhui Lin

Objects

To synthesize current evidence on the impact of cardiac rehabilitation (CR) on acute myocardial infarction (AMI) patients, explore the barriers to effective CR delivery, and evaluate the potential of innovative strategies to enhance the reach and effectiveness of CR programs.

Methods

This systematic review analyzed literature from 2020–2024, focusing on advancements and challenges in CR for AMI patients. A comprehensive search strategy was applied using key terms "cardiac rehabilitation" and "myocardial infarction," encompassing a variety of study designs.

Results

CR significantly improves cardiovascular outcomes in AMI patients, yet faces challenges including low participation rates and adherence issues. Innovative strategies, such as home-based rehabilitation and digital health interventions, have shown potential in enhancing patient engagement and outcomes.

Conclusion

CR is vital for AMI recovery but requires strategies to improve participation and adherence. Future research should focus on optimizing CR strategies to better serve the heart disease patient population. Technological advancements offer promising avenues for more personalized and accessible CR programs.

目的：综合当前有关心脏康复（CR）对急性心肌梗死（AMI）患者影响的证据，探讨有效开展心脏康复的障碍，并评估创新策略的潜力，以提高心脏康复计划的覆盖面和有效性：本系统性综述分析了 2020-2024 年间的文献，重点关注急性心肌梗死患者 CR 方面的进展和挑战。采用 "心脏康复 "和 "心肌梗死 "为关键词的综合检索策略，涵盖了各种研究设计：结果：心脏康复能明显改善急性心肌梗死患者的心血管预后，但也面临着参与率低和坚持治疗等挑战。家庭康复和数字健康干预等创新策略已显示出提高患者参与度和疗效的潜力：CR 对急性心肌梗死患者的康复至关重要，但需要采取策略提高参与度和依从性。未来的研究应侧重于优化 CR 策略，以更好地服务于心脏病患者群体。技术进步为更个性化、更方便的 CR 计划提供了前景广阔的途径。

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引用次数: 0

Linking psoriasis to atrial fibrillation: Insights from "Association between psoriasis and atrial fibrillation: A systematic review and meta-analysis" 牛皮癣与心房颤动之间的关系：从 "牛皮癣与心房颤动之间的关系：从 "牛皮癣与心房颤动之间的关系 "中获得的启示"：牛皮癣与心房颤动之间的关系 "的启示：系统回顾和荟萃分析"：牛皮癣与心房颤动。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102933

Hong Zeng MD , Qi Shu MBBS , Jing Fang MD , Hailin Du MD , Ying Xue MD

Patients with psoriasis indeed face an elevated risk of developing atrial fibrillation (AF), underscoring the need for vigilant monitoring to facilitate early detection and intervention. Given the current body of evidence linking psoriasis and AF is derived from observational studies, there is a clear need for more robust, multicenter, large-scale randomized studies. Such research would help to validate and reinforce the findings from observational data. Large-scale, randomized studies are necessary to confirm the association between psoriasis and AF, addressing potential biases and confounding factors present in observational research. Future studies should consider a broader range of factors that may influence the incidence of AF in psoriasis patients. This includes assessing the impact of AF "burden," which could refer to the frequency, duration, or overall impact of AF episodes on patients' health. Research should delve into the role of genetic predispositions that may contribute to the development of AF in patients with psoriasis. The influence of smoking and lipid levels, among other lifestyle and environmental factors, should be examined for their potential effects on the incidence of AF in psoriasis patients. An interdisciplinary team, including dermatologists, cardiologists, and other healthcare professionals, should collaborate to provide comprehensive care for patients with psoriasis.

银屑病患者罹患心房颤动（房颤）的风险确实较高，这说明有必要进行警惕性监测，以便及早发现和干预。鉴于目前有关银屑病和心房颤动的证据均来自观察性研究，因此显然有必要开展更有力的多中心、大规模随机研究。此类研究将有助于验证和加强观察性数据的发现。有必要开展大规模随机研究，以证实银屑病与房颤之间的关联，同时解决观察性研究中存在的潜在偏差和混杂因素。未来的研究应考虑更多可能影响银屑病患者房颤发生率的因素。这包括评估心房颤动 "负担 "的影响，即心房颤动发作的频率、持续时间或对患者健康的总体影响。研究应深入探讨遗传倾向对银屑病患者心房颤动发生的影响。还应研究吸烟和血脂水平等生活方式和环境因素对银屑病患者房颤发病率的潜在影响。包括皮肤科医生、心脏病专家和其他医护人员在内的跨学科团队应通力合作，为银屑病患者提供全面的护理。

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引用次数: 0

Transcatheter or surgical aortic valve replacement in high-risk patients. Insights from a third-world country 高危患者接受经导管或外科主动脉瓣置换术。来自第三世界国家的启示。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102936

Muddassir Syed Saleem, Nidal Bin Kamran , Hafsa Kaleem

引用次数: 0

The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention SIRT2 在心血管系统中的神秘作用：解密其保护性和破坏性作用，开辟治疗干预的新途径。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102929

Abdulaziz Hassan Alhasaniah , Mohammed Alissa , Fahmy Gad Elsaid , Mahdi H. Alsugoor , Mohammed S AlQahtani , Anwer Alessa , Khalid Jambi , Ghadah Shukri Albakri , Faisal Miqad K. Albaqami , Elizabeth Bennett

Cardiovascular diseases (CVDs) are leading causes of mortality throughout the world, and hence, there is a critical need to elucidate their molecular mechanisms. The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated. However, the precise function of SIRT2 is only partially explored. Here, we review the current understanding of the involvement of SIRT2 in various cardiovascular pathologies, such as cardiac hypertrophy, ischemia-reperfusion injury, diabetic cardiomyopathy, and vascular dysfunction, with emphasis placed on the context-dependent protective or deleterious actions of SIRT2, including its wide array of catalytic activities which span beyond deacetylation. Furthermore, the review uncovers several unresolved research gaps for SIRT2 mechanisms by which SIRT2 modulates cardiac and vascular function during development and aging, thereby paving the way for the discovery of novel therapeutic targets as well as SIRT2-targeted interventions in the prevention and treatment of various cardiovascular diseases.

心血管疾病（CVDs）是导致全球死亡的主要原因，因此迫切需要阐明其分子机制。最近的研究表明，依赖 NAD+ 的 Sirtuin（SIRT）家族在心血管健康和疾病中发挥着关键作用，并且对几种 SIRT 同工酶，特别是 SIRT1 和 SIRT3 进行了大量研究。然而，人们对 SIRT2 的确切功能只进行了部分研究。在此，我们回顾了目前对 SIRT2 参与各种心血管病变（如心肌肥大、缺血再灌注损伤、糖尿病心肌病和血管功能障碍）的理解，重点是 SIRT2 在特定环境下的保护或有害作用，包括其除去乙酰化之外的一系列催化活性。此外，该综述还揭示了 SIRT2 在发育和衰老过程中调节心脏和血管功能的几种尚未解决的研究空白，从而为发现新的治疗靶点以及以 SIRT2 为靶点的干预措施来预防和治疗各种心血管疾病铺平了道路。

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引用次数: 0

Long-term prognosis of elderly patients undergoing atrial septal defect closure: Are we acting too late? 接受房间隔缺损封堵术的老年患者的长期预后：我们的行动是否太晚了？

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102930

Maria Rita Lima , Mariana Sousa Paiva , Sérgio Maltês , Sérgio Madeira , Inês Carmo Mendes , José Pedro Neves , Rui Anjos

Background

Atrial septal defects (ASD) often go unrecognized until very late in life. The impact of ASD closure on life expectancy in elderly patients remains unclear. This study compares the survival of patients≥65-years who underwent ASD closure with their average life expectancy (ALE).

Methods

Single-centre retrospective study including all patients ≥65-years who underwent ostium secundum (OS) ASD closure (surgical/percutaneous) between 1998-2020. Baseline characteristics and the predicted peri-procedural ALE (as determined per pre-defined national ALE tables) for every given patient were assessed.

Results

706 patients underwent OS ASD closure, 37 (5%) had ≥65 years–mean age 69±5 years, 62% presented with heart failure. Mean ASD size=21±9mm, 22% patients had severe tricuspid regurgitation, mean systolic pulmonary artery pressure (SPAP)=50±11mmHg. Five patients were treated surgically. At a mean follow-up of 9±5 years, mortality rate was 46%, occurring 8.8±5.3 years after the procedure. 25 (68%) outlived their predicted ALE. Overall, the mean age of death did not differ from the predicted ALE (79±6 vs. 84±1 years, p=0.304), however there was a 10-year absolute difference between patients who died prematurely vs. those who surpassed ALE (77±4 vs. 87±3 years, p<0.001). Patients who failed to reach ALE had higher SPAP (58±10 vs. 46±8mmHg, p=0.001) and a higher incidence of severe tricuspid regurgitation (42 vs. 12%, p=0.040).

Conclusion

Survival after late ASD closure was comparable to the expected ALE, though one-third of the patients died prematurely. Higher SPAP and severe tricuspid regurgitation were associated with premature death. ASD closure in elderly requires a thorough evaluation to ensure maximum benefit.

背景：房间隔缺损（ASD）通常在晚期才被发现。关闭 ASD 对老年患者预期寿命的影响仍不清楚。本研究比较了年龄≥65 岁、接受了 ASD 关闭术的患者的生存率和平均预期寿命 (ALE)：方法：单中心回顾性研究，包括1998-2020年间所有年龄≥65岁、接受过ostium secundum (OS) ASD闭合术（手术/经皮）的患者。对每位患者的基线特征和术前ALE预测值（根据预先定义的国家ALE表确定）进行了评估：706名患者接受了OS ASD闭合术，其中37人（5%）的年龄≥65岁，平均年龄为69±5岁，62%的患者患有心力衰竭。平均 ASD 大小=21±9mm，22% 的患者有严重的三尖瓣返流，平均肺动脉收缩压（SPAP）=50±11mmHg。五名患者接受了手术治疗。平均随访时间为 9±5 年，死亡率为 46%，发生在术后 8.8±5.3 年。25名患者（68%）的预期ALE寿命超过了预期寿命。总体而言，患者的平均死亡年龄与预测的ALE没有差异（79±6岁 vs. 84±1岁，P=0.304），但早逝患者与超过ALE的患者之间存在10年的绝对差异（77±4岁 vs. 87±3岁，P结论：晚期ASD关闭术后的存活率与预期的ALE相当，但有三分之一的患者过早死亡。较高的 SPAP 和严重的三尖瓣反流与过早死亡有关。对老年人进行 ASD 关闭术需要进行全面评估，以确保获得最大益处。

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引用次数: 0