首页 > 最新文献

Current Problems in Cardiology最新文献

英文 中文
The role and mechanism of TXNDC5 in cardio-oncology: Killing two birds with one stone? TXNDC5在心脏肿瘤中的作用及机制:一石二鸟?
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-05 DOI: 10.1016/j.cpcardiol.2024.102951
Na An , Xiaoyu Zhang , Hongyuan Lin , Qianqian Xu , Qianqian Dai , YiFan Kong , Songjie Han , Xiao Li , Xinyu Yang , Yanwei Xing , Hongcai Shang
Cardio-oncology has emerged as a new translational and clinical field owing to the growing repertory of cancer therapy. To date, there is a lack of effective pharmacological therapy to target cardiotoxicity. Cardio-oncology, which began by investigating the negative effects of cancer medicines on cardiovascular system, has since grown to include research into the similarities between cardiovascular disease (CVD) and cancer. Thioredoxin domain-containing protein 5 (TXNDC5) belongs to the protein disulfide isomerase (PDI) family. Many diseases, including CVD and cancer, improperly express TXNDC5. This review provides a comprehensive analysis of the expression patterns of TXNDC5 in diseases. It outlines the processes via which TXNDC5 contributes to the advancement of malignant diseases such as CVD and cancer. Additionally, it summarizes prospective therapeutic approaches that can be used to target TXNDC5 for the treatment of these diseases. This will offer novel perspectives for enhancing anticancer therapy and advancing cardio-oncology research and drug development.
心脏肿瘤学已成为一个新的转化和临床领域,由于越来越多的储备癌症治疗。迄今为止,缺乏针对心脏毒性的有效药物治疗。心脏肿瘤学最初是研究癌症药物对心血管系统的负面影响,后来发展到研究心血管疾病(CVD)和癌症之间的相似性。含硫氧还蛋白结构域蛋白5 (TXNDC5)属于蛋白二硫异构酶(PDI)家族。许多疾病,包括心血管疾病和癌症,都不正确表达TXNDC5。本文综述了TXNDC5在疾病中的表达模式。它概述了TXNDC5促进心血管疾病和癌症等恶性疾病进展的过程。此外,它还总结了可用于靶向TXNDC5治疗这些疾病的前瞻性治疗方法。这将为加强抗癌治疗和推进心脏肿瘤研究和药物开发提供新的视角。
{"title":"The role and mechanism of TXNDC5 in cardio-oncology: Killing two birds with one stone?","authors":"Na An ,&nbsp;Xiaoyu Zhang ,&nbsp;Hongyuan Lin ,&nbsp;Qianqian Xu ,&nbsp;Qianqian Dai ,&nbsp;YiFan Kong ,&nbsp;Songjie Han ,&nbsp;Xiao Li ,&nbsp;Xinyu Yang ,&nbsp;Yanwei Xing ,&nbsp;Hongcai Shang","doi":"10.1016/j.cpcardiol.2024.102951","DOIUrl":"10.1016/j.cpcardiol.2024.102951","url":null,"abstract":"<div><div>Cardio-oncology has emerged as a new translational and clinical field owing to the growing repertory of cancer therapy. To date, there is a lack of effective pharmacological therapy to target cardiotoxicity. Cardio-oncology, which began by investigating the negative effects of cancer medicines on cardiovascular system, has since grown to include research into the similarities between cardiovascular disease (CVD) and cancer. Thioredoxin domain-containing protein 5 (TXNDC5) belongs to the protein disulfide isomerase (PDI) family. Many diseases, including CVD and cancer, improperly express TXNDC5. This review provides a comprehensive analysis of the expression patterns of TXNDC5 in diseases. It outlines the processes via which TXNDC5 contributes to the advancement of malignant diseases such as CVD and cancer. Additionally, it summarizes prospective therapeutic approaches that can be used to target TXNDC5 for the treatment of these diseases. This will offer novel perspectives for enhancing anticancer therapy and advancing cardio-oncology research and drug development.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 3","pages":"Article 102951"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular outcomes of patients with atrial fibrillation and concomitant cardiac amyloidosis undergoing percutaneous catheter ablation 经皮导管消融房颤合并心脏淀粉样变性患者的心血管预后。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-02 DOI: 10.1016/j.cpcardiol.2024.102953
Garba Rimamskep Shamaki MD , Siva Neppala MD , Sinda Hidri MD , Priya Hotwani MD , Mohammed Aldabagh MD , Sundal Aziz MD , Prakash Upreti MD , Amith Seri MBBS , Dilesha Dilangi Kumanayaka MD , Ebenezer Oloyede MD, MPH , Yasar Sattar MD

Background

Atrial fibrillation has been linked with poor outcomes in patients with cardiac amyloidosis. We evaluate the in-hospital outcomes of patients with atrial fibrillation and concomitant cardiac amyloidosis with and without catheter ablation.

Methods

The National Inpatient Sample databases (2016 to 2021) were queried to identify patients admitted with atrial fibrillation and concomitant cardiac amyloidosis using ICD 10 codes. The study population aged >18 years was divided into two cohorts; ablation (AB) vs. no ablation (NAB). Multivariate logistic regression model adjusting for baseline characteristics and comorbidities. The primary outcome was all-cause in-hospital mortality. Secondary outcomes were acute heart failure, cardiogenic shock, ventricular fibrillation, major bleeding, stroke, length of stay, and hospitalization cost.

Results

73,160 patients were identified. 595(0.8 %) underwent ablation and 72,656 (99.2 %) did not. Both NAB and AB patients were predominantly white (69.6 % and 60.3 %) respectively. AB patients were younger with median age [74 years (IQR 66-80) vs. 78 years (IQR 71-84), p < 0.01], compared with NAB patients. AB patients were more likely to have heart failure (76.5 % vs. 65.3 %, p = 0.04), and have a family history of CAD (11.1 % vs. 4.8 %, p = 0.03). Contrarily, NAB patients were more likely to have dementia (11.5 % vs. 2.5 %, p = 0.01). After adjusting for baseline characteristics and comorbidity, there was no difference in all-cause mortality (OR 0.3, CI 0.08-1.35, p = 0.12), stroke (OR 1.1, CI 0.4-2.8, p = 0.87), or major bleeding (OR 1.4, CI 0.7-2.6, p = 0.37). Undergoing ablation was associated with higher odds of acute heart failure (OR 1.9, CI 1.1-3.3, p<0.01). After adjusting for inflation using the consumer price index, adjusted total cost of hospitalization was for higher AB patients was compared to NAB patients ($41,499.22 vs. $13,085.11) with a significantly longer length of stay among AB patients (7 days vs. 5days, p < 0.01).

Conclusion

Atrial fibrillation and concomitant cardiac amyloidosis in patients undergoing catheter ablation are associated with an increased risk of acute heart failure, higher cost, and a longer length of stay.
背景:心房颤动与心脏淀粉样变性患者预后不良有关。我们评估心房颤动和合并心脏淀粉样变性患者的住院结果,有和没有导管消融。方法:查询2016 - 2021年全国住院患者样本数据库,使用ICD 10编码识别心房颤动合并心脏淀粉样变性患者。年龄在18岁至18岁之间的研究人群分为两组;消融(AB)与无消融(NAB)。调整基线特征和合并症的多变量logistic回归模型。主要结局为全因住院死亡率。次要结局为大出血、卒中住院时间和住院费用。结果:共发现73,160例患者。595例(0.8%)行消融术,72656例(99.2%)未行消融术。NAB和AB患者均以白人为主(分别为69.6%和60.3%)。AB患者更年轻,中位年龄为74岁(IQR 66-80) vs. 78岁(IQR 71-84)。结论:导管消融患者心房颤动和合并心脏淀粉样变性与急性心力衰竭风险增加、费用增加和住院时间延长相关。
{"title":"Cardiovascular outcomes of patients with atrial fibrillation and concomitant cardiac amyloidosis undergoing percutaneous catheter ablation","authors":"Garba Rimamskep Shamaki MD ,&nbsp;Siva Neppala MD ,&nbsp;Sinda Hidri MD ,&nbsp;Priya Hotwani MD ,&nbsp;Mohammed Aldabagh MD ,&nbsp;Sundal Aziz MD ,&nbsp;Prakash Upreti MD ,&nbsp;Amith Seri MBBS ,&nbsp;Dilesha Dilangi Kumanayaka MD ,&nbsp;Ebenezer Oloyede MD, MPH ,&nbsp;Yasar Sattar MD","doi":"10.1016/j.cpcardiol.2024.102953","DOIUrl":"10.1016/j.cpcardiol.2024.102953","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation has been linked with poor outcomes in patients with cardiac amyloidosis. We evaluate the in-hospital outcomes of patients with atrial fibrillation and concomitant cardiac amyloidosis with and without catheter ablation.</div></div><div><h3>Methods</h3><div>The National Inpatient Sample databases (2016 to 2021) were queried to identify patients admitted with atrial fibrillation and concomitant cardiac amyloidosis using ICD 10 codes. The study population aged &gt;18 years was divided into two cohorts; ablation (AB) vs. no ablation (NAB). Multivariate logistic regression model adjusting for baseline characteristics and comorbidities. The primary outcome was all-cause in-hospital mortality. Secondary outcomes were acute heart failure, cardiogenic shock, ventricular fibrillation, major bleeding, stroke, length of stay, and hospitalization cost.</div></div><div><h3>Results</h3><div>73,160 patients were identified. 595(0.8 %) underwent ablation and 72,656 (99.2 %) did not. Both NAB and AB patients were predominantly white (69.6 % and 60.3 %) respectively. AB patients were younger with median age [74 years (IQR 66-80) vs. 78 years (IQR 71-84), p &lt; 0.01], compared with NAB patients. AB patients were more likely to have heart failure (76.5 % vs. 65.3 %, p = 0.04), and have a family history of CAD (11.1 % vs. 4.8 %, p = 0.03). Contrarily, NAB patients were more likely to have dementia (11.5 % vs. 2.5 %, p = 0.01). After adjusting for baseline characteristics and comorbidity, there was no difference in all-cause mortality (OR 0.3, CI 0.08-1.35, p = 0.12), stroke (OR 1.1, CI 0.4-2.8, p = 0.87), or major bleeding (OR 1.4, CI 0.7-2.6, p = 0.37). Undergoing ablation was associated with higher odds of acute heart failure (OR 1.9, CI 1.1-3.3, p&lt;0.01). After adjusting for inflation using the consumer price index, adjusted total cost of hospitalization was for higher AB patients was compared to NAB patients ($41,499.22 vs. $13,085.11) with a significantly longer length of stay among AB patients (7 days vs. 5days, p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Atrial fibrillation and concomitant cardiac amyloidosis in patients undergoing catheter ablation are associated with an increased risk of acute heart failure, higher cost, and a longer length of stay.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 3","pages":"Article 102953"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrative approaches to atrial fibrillation prevention and management: Leveraging gut health for improved cardiovascular outcomes in the aging population 房颤预防和管理的综合方法:利用肠道健康改善老年人群心血管结局
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.cpcardiol.2024.102952
Emma Grace Williams , Mohammed Alissa , Mahdi H. Alsugoor , Ghadah Shukri Albakri , Ali A Altamimi , Abdulmajeed Abdulaziz Alabdullateef , Nahlah Makki Almansour , Fahad M. Aldakheel , Salem Alessa , Michael Marber
Atrial fibrillation (AF) is a prevalent clinical arrhythmia associated with a high incidence and severe complications such as cerebral embolism and heart failure. While the etiology and pathogenesis of AF involve numerous factors, recent research emphasizes the significant role of intestinal microbiota imbalance in the emergence and progression of AF, particularly among older adults. This review investigates the mechanisms by which intestinal flora and their metabolites contribute to the onset of AF in the elderly, highlighting novel interactions between gut health and cardiac function. Current literature often overlooks these critical connections, indicating a substantial research gap in understanding how dysbiosis may exacerbate AF and hinder recovery. Furthermore, exploring the bidirectional relationship between the gut microbiome and systemic inflammation in the context of AF provides a unique perspective that has yet to be thoroughly investigated. Future research should focus on longitudinal studies assessing gut microbiota composition and function in AF patients and consider probiotics or prebiotics as potential adjunctive therapies for mitigating AF. This comprehensive approach may pave the way for innovative treatments integrating cardiology with gastroenterology, enhancing patient outcomes through a holistic understanding of health.
心房颤动(AF)是一种常见的临床心律失常,发病率高,并发症严重,如脑栓塞和心力衰竭。虽然房颤的病因和发病机制涉及许多因素,但最近的研究强调了肠道微生物群失衡在房颤的发生和进展中的重要作用,特别是在老年人中。这篇综述探讨了肠道菌群及其代谢物促进老年人房颤发病的机制,强调了肠道健康和心功能之间的新相互作用。目前的文献往往忽略了这些关键的联系,表明在理解生态失调如何加剧房颤并阻碍康复方面存在实质性的研究空白。此外,在房颤的背景下,探索肠道微生物群和全身性炎症之间的双向关系提供了一个独特的视角,但尚未得到彻底的研究。未来的研究应侧重于评估房颤患者肠道微生物群组成和功能的纵向研究,并考虑将益生菌或益生元作为缓解房颤的潜在辅助疗法。这种综合方法可能为将心脏病学与胃肠病学相结合的创新治疗铺平道路,通过全面了解健康状况来提高患者的预后。
{"title":"Integrative approaches to atrial fibrillation prevention and management: Leveraging gut health for improved cardiovascular outcomes in the aging population","authors":"Emma Grace Williams ,&nbsp;Mohammed Alissa ,&nbsp;Mahdi H. Alsugoor ,&nbsp;Ghadah Shukri Albakri ,&nbsp;Ali A Altamimi ,&nbsp;Abdulmajeed Abdulaziz Alabdullateef ,&nbsp;Nahlah Makki Almansour ,&nbsp;Fahad M. Aldakheel ,&nbsp;Salem Alessa ,&nbsp;Michael Marber","doi":"10.1016/j.cpcardiol.2024.102952","DOIUrl":"10.1016/j.cpcardiol.2024.102952","url":null,"abstract":"<div><div>Atrial fibrillation (AF) is a prevalent clinical arrhythmia associated with a high incidence and severe complications such as cerebral embolism and heart failure. While the etiology and pathogenesis of AF involve numerous factors, recent research emphasizes the significant role of intestinal microbiota imbalance in the emergence and progression of AF, particularly among older adults. This review investigates the mechanisms by which intestinal flora and their metabolites contribute to the onset of AF in the elderly, highlighting novel interactions between gut health and cardiac function. Current literature often overlooks these critical connections, indicating a substantial research gap in understanding how dysbiosis may exacerbate AF and hinder recovery. Furthermore, exploring the bidirectional relationship between the gut microbiome and systemic inflammation in the context of AF provides a unique perspective that has yet to be thoroughly investigated. Future research should focus on longitudinal studies assessing gut microbiota composition and function in AF patients and consider probiotics or prebiotics as potential adjunctive therapies for mitigating AF. This comprehensive approach may pave the way for innovative treatments integrating cardiology with gastroenterology, enhancing patient outcomes through a holistic understanding of health.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 3","pages":"Article 102952"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stratifying clinically relevant risk factors for acute ischemic stroke and cerebrovascular events in chagas disease: A systematic review and meta-Analysis 分层查加斯病急性缺血性卒中和脑血管事件的临床相关危险因素:系统回顾和荟萃分析
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.cpcardiol.2024.102950
Ocílio Ribeiro Gonçalves M.S. , Saul Dominici M.S. , Júlia dos Santos Monteiro M.S. , Elizabet Taylor Pimenta Weba M.S. , Anthony Hong M.S. , Ana Beatriz Santos M.S. , Maria Tereza Camarotti M.S. , Niels Pacheco M.D. , João Victor Araújo de Oliveira M.S. , Arlindo Bispo da Silva Junior M.S. , Márcio Yuri Ferreira M.D. , Kelson James Almeida M.D. Ph.D.

Background

Chagas Disease (CD) poses significant health risks, including an increased incidence of acute ischemic stroke (AIS). However, the specific risk factors for AIS in CD patients are not well-defined. This meta-analysis aims to identify clinically relevant risk factors for AIS in individuals with CD.

Methods

We performed a systematic review and meta-analysis by searching PubMed, Embase, Web of Science, and the Cochrane Library up to August 2024. Primary outcomes evaluated in AIS patients with CD included reduced left ventricular ejection fraction (LVEF), anticoagulation therapy, atrial fibrillation (AF), left ventricular apical aneurysm (LVAA), pacemaker use, and coronary artery disease (CAD). Risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.

Results

Six studies were included, involving 1,229 patients (48% male). The analysis revealed a higher risk of AIS in CD patients with reduced LVEF (RR 3.38; 95% CI 1.38 - 8.27), AF (OR 4.85; 95% CI 2.13 - 11.02), LVAA (OR 3.76; 95% CI 1.96 - 7.21), and pacemaker use (OR 2.37; 95% CI 1.38 - 4.09). Anticoagulation therapy was associated with a reduced likelihood of stroke (OR 0.28; 95% CI 0.19 - 0.41). No significant association was found between CAD and stroke risk (OR 1.56; 95% CI 0.93 - 2.59).

Conclusion

Reduced LVEF, AF, LVAA, and pacemaker use are correlated with higher stroke incidence in CD patients, while anticoagulation therapy diminishes this risk. Further randomized studies are needed to refine AIS prevention strategies for this population.
背景:恰加斯病(CD)具有显著的健康风险,包括急性缺血性卒中(AIS)的发病率增加。然而,乳糜泻患者AIS的具体危险因素尚未明确。本荟萃分析旨在确定cd患者AIS的临床相关危险因素。方法:我们通过检索PubMed, Embase, Web of Science和Cochrane图书馆进行了系统回顾和荟萃分析,截止到2024年8月。评估AIS合并CD患者的主要结局包括左室射血分数(LVEF)降低、抗凝治疗、心房颤动(AF)、左室顶动脉瘤(LVAA)、起搏器使用和冠状动脉疾病(CAD)。采用随机效应模型计算95%置信区间(ci)的风险比(rr)和优势比(ORs)。结果:纳入6项研究,涉及1229例患者(48%为男性)。分析显示,LVEF降低的CD患者发生AIS的风险更高(RR 3.38;95% ci 1.38 - 8.27), af(或4.85;95% ci 2.13 - 11.02), lvaa(或3.76;95% CI 1.96 - 7.21),起搏器使用(OR 2.37;95% ci 1.38 - 4.09)。抗凝治疗与卒中可能性降低相关(OR 0.28;95% ci 0.19 - 0.41)。冠心病与卒中风险之间没有显著关联(OR 1.56;95% ci 0.93 - 2.59)。结论:降低LVEF、AF、lveaa和使用起搏器与CD患者卒中发生率升高相关,而抗凝治疗可降低这一风险。需要进一步的随机研究来完善针对这一人群的AIS预防策略。
{"title":"Stratifying clinically relevant risk factors for acute ischemic stroke and cerebrovascular events in chagas disease: A systematic review and meta-Analysis","authors":"Ocílio Ribeiro Gonçalves M.S. ,&nbsp;Saul Dominici M.S. ,&nbsp;Júlia dos Santos Monteiro M.S. ,&nbsp;Elizabet Taylor Pimenta Weba M.S. ,&nbsp;Anthony Hong M.S. ,&nbsp;Ana Beatriz Santos M.S. ,&nbsp;Maria Tereza Camarotti M.S. ,&nbsp;Niels Pacheco M.D. ,&nbsp;João Victor Araújo de Oliveira M.S. ,&nbsp;Arlindo Bispo da Silva Junior M.S. ,&nbsp;Márcio Yuri Ferreira M.D. ,&nbsp;Kelson James Almeida M.D. Ph.D.","doi":"10.1016/j.cpcardiol.2024.102950","DOIUrl":"10.1016/j.cpcardiol.2024.102950","url":null,"abstract":"<div><h3>Background</h3><div>Chagas Disease (CD) poses significant health risks, including an increased incidence of acute ischemic stroke (AIS). However, the specific risk factors for AIS in CD patients are not well-defined. This meta-analysis aims to identify clinically relevant risk factors for AIS in individuals with CD.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis by searching PubMed, Embase, Web of Science, and the Cochrane Library up to August 2024. Primary outcomes evaluated in AIS patients with CD included reduced left ventricular ejection fraction (LVEF), anticoagulation therapy, atrial fibrillation (AF), left ventricular apical aneurysm (LVAA), pacemaker use, and coronary artery disease (CAD). Risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.</div></div><div><h3>Results</h3><div>Six studies were included, involving 1,229 patients (48% male). The analysis revealed a higher risk of AIS in CD patients with reduced LVEF (RR 3.38; 95% CI 1.38 - 8.27), AF (OR 4.85; 95% CI 2.13 - 11.02), LVAA (OR 3.76; 95% CI 1.96 - 7.21), and pacemaker use (OR 2.37; 95% CI 1.38 - 4.09). Anticoagulation therapy was associated with a reduced likelihood of stroke (OR 0.28; 95% CI 0.19 - 0.41). No significant association was found between CAD and stroke risk (OR 1.56; 95% CI 0.93 - 2.59).</div></div><div><h3>Conclusion</h3><div>Reduced LVEF, AF, LVAA, and pacemaker use are correlated with higher stroke incidence in CD patients, while anticoagulation therapy diminishes this risk. Further randomized studies are needed to refine AIS prevention strategies for this population.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 3","pages":"Article 102950"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An insight regarding the article ‘Predictors and rate of survival after out-of-hospital cardiac arrest.’ 关于“院外心脏骤停后的预测因素和存活率”一文的见解。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-28 DOI: 10.1016/j.cpcardiol.2024.102946
Jinfeng Li MD, Lei Bao MD, Mengyue Gu MD, Mengmei Wang MD, Hui Zhong MBBS
Advancements in diagnostic and therapeutic approaches have led to a remarkable reduction in the morbidity and mortality rates associated with a variety of diseases. In the context of acute ischemic heart disease, significant milestones have been achieved, beginning with the establishment of cardiac ICUs. These were pivotal in providing specialized care for patients with severe heart conditions. Subsequent to this development, methods to restore blood flow in areas compromised by arterial blockages were introduced. Initially, systemic thrombolysis was the primary method used, but it has since been largely supplanted by primary percutaneous coronary intervention (PCI), also known as primary coronary angioplasty, which is now the preferred treatment due to its effectiveness and safety. The incidence of out-of-hospital cardiac arrest (OHCA) where resuscitation attempts have been made, whether successful or not, is significant and presents a considerable challenge. Unfortunately, the mortality rate among these patients remains distressingly high, and efforts to reduce it are fraught with difficulty. It is crucial to acknowledge that survival from an OHCA does not automatically equate to a favorable clinical outcome, as serious neurological impairments are common sequelae of such events. In addition to mortality rates, the term "survival with favorable neurologic outcome" has emerged as another critical measure of the success of resuscitation efforts. This parameter underscores the importance of not only saving lives but also preserving the quality of life for survivors. The ability to restore both life and cognitive function is a testament to the comprehensiveness of care provided to OHCA patients.
诊断和治疗方法的进步使与各种疾病有关的发病率和死亡率显著降低。在急性缺血性心脏病的背景下,从建立心脏icu开始,已经取得了重要的里程碑。这些在为患有严重心脏病的患者提供专门护理方面至关重要。在这一发展之后,介绍了恢复动脉阻塞损害区域血流的方法。最初,全身溶栓是使用的主要方法,但它已被主要经皮冠状动脉介入治疗(PCI)所取代,也被称为初级冠状动脉成形术,由于其有效性和安全性,它现在是首选的治疗方法。院外心脏骤停(OHCA)的发生率,在复苏尝试,无论成功与否,是显著的,并提出了相当大的挑战。不幸的是,这些病人的死亡率仍然高得令人痛心,降低死亡率的努力充满了困难。重要的是要认识到,OHCA的生存并不自动等同于良好的临床结果,因为严重的神经损伤是此类事件的常见后遗症。除了死亡率外,“具有良好神经预后的生存”一词已成为衡量复苏努力成功与否的另一个关键指标。这一参数强调了不仅要挽救生命,而且要保证幸存者的生活质量的重要性。恢复生命和认知功能的能力证明了向OHCA患者提供的全面护理。
{"title":"An insight regarding the article ‘Predictors and rate of survival after out-of-hospital cardiac arrest.’","authors":"Jinfeng Li MD,&nbsp;Lei Bao MD,&nbsp;Mengyue Gu MD,&nbsp;Mengmei Wang MD,&nbsp;Hui Zhong MBBS","doi":"10.1016/j.cpcardiol.2024.102946","DOIUrl":"10.1016/j.cpcardiol.2024.102946","url":null,"abstract":"<div><div>Advancements in diagnostic and therapeutic approaches have led to a remarkable reduction in the morbidity and mortality rates associated with a variety of diseases. In the context of acute ischemic heart disease, significant milestones have been achieved, beginning with the establishment of cardiac ICUs. These were pivotal in providing specialized care for patients with severe heart conditions. Subsequent to this development, methods to restore blood flow in areas compromised by arterial blockages were introduced. Initially, systemic thrombolysis was the primary method used, but it has since been largely supplanted by primary percutaneous coronary intervention (PCI), also known as primary coronary angioplasty, which is now the preferred treatment due to its effectiveness and safety. The incidence of out-of-hospital cardiac arrest (OHCA) where resuscitation attempts have been made, whether successful or not, is significant and presents a considerable challenge. Unfortunately, the mortality rate among these patients remains distressingly high, and efforts to reduce it are fraught with difficulty. It is crucial to acknowledge that survival from an OHCA does not automatically equate to a favorable clinical outcome, as serious neurological impairments are common sequelae of such events. In addition to mortality rates, the term \"survival with favorable neurologic outcome\" has emerged as another critical measure of the success of resuscitation efforts. This parameter underscores the importance of not only saving lives but also preserving the quality of life for survivors. The ability to restore both life and cognitive function is a testament to the comprehensiveness of care provided to OHCA patients.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102946"},"PeriodicalIF":3.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for Readers 读者信息
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00575-9
{"title":"Information for Readers","authors":"","doi":"10.1016/S0146-2806(24)00575-9","DOIUrl":"10.1016/S0146-2806(24)00575-9","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102940"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Title Page 标题页
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00574-7
{"title":"Title Page","authors":"","doi":"10.1016/S0146-2806(24)00574-7","DOIUrl":"10.1016/S0146-2806(24)00574-7","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102939"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guidelines for Authors 作者指南
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00580-2
{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0146-2806(24)00580-2","DOIUrl":"10.1016/S0146-2806(24)00580-2","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102945"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor’s Message 编辑致辞
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00579-6
{"title":"Editor’s Message","authors":"","doi":"10.1016/S0146-2806(24)00579-6","DOIUrl":"10.1016/S0146-2806(24)00579-6","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102944"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “HIV-Related Atherosclerosis: State-of-the-Art-Review” [Current Problems in Cardiology, Volume 48, Issue 9, September 2023, 101783] 与艾滋病毒相关的动脉粥样硬化:最新进展综述》[《心脏病学当前问题》,第 48 卷第 9 期,2023 年 9 月,101783] 更正
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-26 DOI: 10.1016/j.cpcardiol.2024.102928
Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Olga Urazova , Artem Trofimenko , Grizelda Navarsdyan , Zinaida Jndoyan , Kristina Abgaryan , Federica Fogacci , Mattia Galli , Luciano Agati , Zhanna Kobalava , Davood Shafie , Mario Marzilli , Liana Gogiashvili , Nizal Sarrafzadegan
{"title":"Corrigendum to “HIV-Related Atherosclerosis: State-of-the-Art-Review” [Current Problems in Cardiology, Volume 48, Issue 9, September 2023, 101783]","authors":"Ashot Avagimyan ,&nbsp;Nana Pogosova ,&nbsp;Lev Kakturskiy ,&nbsp;Mohammad Sheibani ,&nbsp;Olga Urazova ,&nbsp;Artem Trofimenko ,&nbsp;Grizelda Navarsdyan ,&nbsp;Zinaida Jndoyan ,&nbsp;Kristina Abgaryan ,&nbsp;Federica Fogacci ,&nbsp;Mattia Galli ,&nbsp;Luciano Agati ,&nbsp;Zhanna Kobalava ,&nbsp;Davood Shafie ,&nbsp;Mario Marzilli ,&nbsp;Liana Gogiashvili ,&nbsp;Nizal Sarrafzadegan","doi":"10.1016/j.cpcardiol.2024.102928","DOIUrl":"10.1016/j.cpcardiol.2024.102928","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102928"},"PeriodicalIF":3.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current Problems in Cardiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1