Pub Date : 2024-09-10DOI: 10.1016/S0146-2806(24)00485-7
{"title":"Table of Content","authors":"","doi":"10.1016/S0146-2806(24)00485-7","DOIUrl":"10.1016/S0146-2806(24)00485-7","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 11","pages":"Article 102850"},"PeriodicalIF":3.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146280624004857/pdfft?md5=462d9bc8bf522a43b5f861c3cf4c4794&pid=1-s2.0-S0146280624004857-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulmonary arterial hypertension (PAH) is a major concern in patients with Down syndrome (DS) and congenital heart disease (CHD). Understanding the unique characteristics of PAH in these populations is essential for developing tailored management strategies. This review examines differences in PAH between DS and non-DS (nDS) patients with CHD, focusing on pathophysiology, clinical presentation, hemodynamic profiles, and treatment outcomes.
Methods
A retrospective analysis of 93 adults with PAH was conducted, including 18 with DS and 75 with CHD but without DS (nDS). Data on demographics, clinical presentations, comorbidities, and hemodynamic parameters were collected using echocardiography and right heart catheterization. Statistical analyses included Mann–Whitney U tests, Student's t-tests, and Kaplan–Meier survival analysis to compare the DS and nDS groups.
Results
DS patients presented with PAH at a younger age (mean age 25.06 years) compared to nDS patients (mean age 42.4 years; p < 0.001). Hypothyroidism was more prevalent in DS patients (61.1 %) than in nDS patients (29.3 %; p = 0.012). Hemodynamic assessments showed lower mean arterial pressure (MAP) in DS patients (76.24 ± 11.6 mmHg) versus nDS patients (93.95 ± 15 mmHg; p < 0.001), and a higher TAPSE/PASP ratio (0.41 vs. 0.23; p = 0.009), suggesting less severe right ventricular dysfunction. DS patients had a significant survival advantage over nDS patients (p = 0.043).
Conclusions
DS patients have distinct clinical and hemodynamic profiles in PAH, requiring personalized management. Early detection and tailored treatment are crucial for improving outcomes. Further research should refine these strategies and explore new therapies.
{"title":"Updated review on pulmonary arterial hypertension: Differences between down syndrome and non-down syndrome populations","authors":"Guillermo Cueto-Robledo MD , Ernesto Roldan-Valadez MD, MSc, DSc , Melissa Garcia-Lezama MD , Marisol Garcia-Cesar MD , Dulce-Iliana Navarro-Vergara MD, MSc , Maria-Berenice Torres-Rojas MD","doi":"10.1016/j.cpcardiol.2024.102840","DOIUrl":"10.1016/j.cpcardiol.2024.102840","url":null,"abstract":"<div><h3>Background</h3><p>Pulmonary arterial hypertension (PAH) is a major concern in patients with Down syndrome (DS) and congenital heart disease (CHD). Understanding the unique characteristics of PAH in these populations is essential for developing tailored management strategies. This review examines differences in PAH between DS and non-DS (nDS) patients with CHD, focusing on pathophysiology, clinical presentation, hemodynamic profiles, and treatment outcomes.</p></div><div><h3>Methods</h3><p>A retrospective analysis of 93 adults with PAH was conducted, including 18 with DS and 75 with CHD but without DS (nDS). Data on demographics, clinical presentations, comorbidities, and hemodynamic parameters were collected using echocardiography and right heart catheterization. Statistical analyses included Mann–Whitney U tests, Student's <em>t</em>-tests, and Kaplan–Meier survival analysis to compare the DS and nDS groups.</p></div><div><h3>Results</h3><p>DS patients presented with PAH at a younger age (mean age 25.06 years) compared to nDS patients (mean age 42.4 years; <em>p</em> < 0.001). Hypothyroidism was more prevalent in DS patients (61.1 %) than in nDS patients (29.3 %; <em>p</em> = 0.012). Hemodynamic assessments showed lower mean arterial pressure (MAP) in DS patients (76.24 ± 11.6 mmHg) versus nDS patients (93.95 ± 15 mmHg; <em>p</em> < 0.001), and a higher TAPSE/PASP ratio (0.41 vs. 0.23; <em>p</em> = 0.009), suggesting less severe right ventricular dysfunction. DS patients had a significant survival advantage over nDS patients (<em>p</em> = 0.043).</p></div><div><h3>Conclusions</h3><p>DS patients have distinct clinical and hemodynamic profiles in PAH, requiring personalized management. Early detection and tailored treatment are crucial for improving outcomes. Further research should refine these strategies and explore new therapies.</p></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 12","pages":"Article 102840"},"PeriodicalIF":3.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-10DOI: 10.1016/S0146-2806(24)00486-9
{"title":"Information for Readers","authors":"","doi":"10.1016/S0146-2806(24)00486-9","DOIUrl":"10.1016/S0146-2806(24)00486-9","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 11","pages":"Article 102851"},"PeriodicalIF":3.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-10DOI: 10.1016/S0146-2806(24)00484-5
{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0146-2806(24)00484-5","DOIUrl":"10.1016/S0146-2806(24)00484-5","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 11","pages":"Article 102849"},"PeriodicalIF":3.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146280624004845/pdfft?md5=7b71d9d7a8ec6d7056015b2d60bebbbc&pid=1-s2.0-S0146280624004845-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-07DOI: 10.1016/j.cpcardiol.2024.102835
Nicolaas P. Pronk PhD, MA , Colin Woodard MA, FRGS , D. Brad Rindal DDS , Ross Arena PhD, PT
Objectives
Health and social factors show large heterogeneity across regional cultural geographies and influence oral health as well. The purpose of this study is to confirm associations between county-level general health, behaviors, social factors, and oral health indicators and to further analyze the patterns of distribution of oral health indicators across dominant regional cultures in the United States (US) as defined by the American Nations model.
Methods
We calculated a Lifestyle Health Index (LHI) from the 2023 PLACES database using county-level, age-adjusted health data and merged it with (a) 2020 Social Vulnerability Index (SVI) database, (b) dominant regional cultures from Nationhood Lab's American Nations model, (c) dentist visits and teeth lost data from the 2023 PLACES database, and (d) access to dentistry data from the County Health Rankings database.
Results
Correlation coefficients between the LHI (and sub scores), SVI (and sub scores), and dental variables showed strong associations. ANOVA post-hoc test results revealed significant differences for dental visits and teeth lost for LHI, SVI and access to dentists. Prevalence of dental visits and teeth lost showed clear heterogeneity across regional cultures.
Conclusions
Oral health is strongly linked to lifestyle health factors, social vulnerability, access to dentistry, and cultural norms and belief systems. Within the US, significant heterogeneity exists in the distribution of oral health indicators across dominant regional cultural geographies. Oral health communications and policy solutions focused on health-related behaviors (e.g., tobacco, diet), disease-specific considerations (e.g., diabetes), and the social environment (e.g., poverty, housing) should be tailored to regional cultures rather than a single US-based culture to improve dental care and oral health outcomes.
{"title":"Exploring the complex relationships between health behaviors, health outcomes, social vulnerability, regional cultures, and oral health","authors":"Nicolaas P. Pronk PhD, MA , Colin Woodard MA, FRGS , D. Brad Rindal DDS , Ross Arena PhD, PT","doi":"10.1016/j.cpcardiol.2024.102835","DOIUrl":"10.1016/j.cpcardiol.2024.102835","url":null,"abstract":"<div><h3>Objectives</h3><p>Health and social factors show large heterogeneity across regional cultural geographies and influence oral health as well. The purpose of this study is to confirm associations between county-level general health, behaviors, social factors, and oral health indicators and to further analyze the patterns of distribution of oral health indicators across dominant regional cultures in the United States (US) as defined by the American Nations model.</p></div><div><h3>Methods</h3><p>We calculated a Lifestyle Health Index (LHI) from the 2023 PLACES database using county-level, age-adjusted health data and merged it with (a) 2020 Social Vulnerability Index (SVI) database, (b) dominant regional cultures from Nationhood Lab's American Nations model, (c) dentist visits and teeth lost data from the 2023 PLACES database, and (d) access to dentistry data from the County Health Rankings database.</p></div><div><h3>Results</h3><p>Correlation coefficients between the LHI (and sub scores), SVI (and sub scores), and dental variables showed strong associations. ANOVA post-hoc test results revealed significant differences for dental visits and teeth lost for LHI, SVI and access to dentists. Prevalence of dental visits and teeth lost showed clear heterogeneity across regional cultures.</p></div><div><h3>Conclusions</h3><p>Oral health is strongly linked to lifestyle health factors, social vulnerability, access to dentistry, and cultural norms and belief systems. Within the US, significant heterogeneity exists in the distribution of oral health indicators across dominant regional cultural geographies. Oral health communications and policy solutions focused on health-related behaviors (e.g., tobacco, diet), disease-specific considerations (e.g., diabetes), and the social environment (e.g., poverty, housing) should be tailored to regional cultures rather than a single US-based culture to improve dental care and oral health outcomes.</p></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 12","pages":"Article 102835"},"PeriodicalIF":3.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146280624004705/pdfft?md5=6a6f9d278a8e5e345d9d0e4a8c2ac820&pid=1-s2.0-S0146280624004705-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-04DOI: 10.1016/j.cpcardiol.2024.102839
Patricia Palau MD, PhD , Julio Núñez MD, PhD , Eloy Domínguez MD, PhD , Rafael de la Espriella MD, PhD , Gonzalo Núñez MD , Cristina Flor PhD , Ivan de Amo , Jose Casaña PhD , Joaquin Calatayud PhD , Lucía Ortega PhD , Paloma Marín PhD , Juan Sanchis MD, PhD , Fabian Sanchis-Gomar MD, PhD , Laura López MD, PhD
Background
Chronotropic incompetence (ChI) is linked with diminished exercise capacity in heart failure with preserved ejection fraction (HFpEF). Although exercise training has shown potential for improving functional capacity, the exercise modality associated with greater functional and chronotropic response (ChR) is not well-known. Additionally, how the ChR from different exercise modalities mediates functional improvement remains to be determined. This study aimed to evaluate the effect of three different exercise programs over current guideline recommendations on peak oxygen consumption (peakVO2) in patients with ChI HFpEF phenotype.
Methods and results
In this randomized clinical trial, 80 stable symptomatic patients with HFpEF and ChI (NYHA class II-III/IV) are randomized (1:1:1:1) to receive: a) a 12-week program of supervised aerobic training (AT), b) AT and low to moderate-intensity strength training, c)AT and moderate to high-intensity strength training, or d) guideline-based physical activity and exercise recommendations. The primary endpoint is 12-week changes in peakVO2. The secondary endpoints are 12-week changes in ChR, 12-week changes in quality of life, and how ChR changes mediate changes in peakVO2. A mixed-effects model for repeated measures will be used to compare endpoint changes. The mean age is 75.1 ± 7.2 years, and most patients are women (57.5 %) in New York Heart Association functional class II (68.7 %). The mean peakVO2, percent of predicted peakVO2, and ChR are 11.8 ± 2.6 mL/kg/min, 67.2 ± 14.7 %, and 0.39 ± 0.16, respectively. No significant baseline clinical differences between arms are found.
Conclusions
Training-HR will evaluate the effects of different exercise-based therapies on peakVO2, ChR, and quality of life in patients with ChI HFpEF phenotype.
{"title":"Effect of exercise training in patients with chronotropic incompetence and heart failure with preserved ejection fraction: Training-HR study protocol","authors":"Patricia Palau MD, PhD , Julio Núñez MD, PhD , Eloy Domínguez MD, PhD , Rafael de la Espriella MD, PhD , Gonzalo Núñez MD , Cristina Flor PhD , Ivan de Amo , Jose Casaña PhD , Joaquin Calatayud PhD , Lucía Ortega PhD , Paloma Marín PhD , Juan Sanchis MD, PhD , Fabian Sanchis-Gomar MD, PhD , Laura López MD, PhD","doi":"10.1016/j.cpcardiol.2024.102839","DOIUrl":"10.1016/j.cpcardiol.2024.102839","url":null,"abstract":"<div><h3>Background</h3><p>Chronotropic incompetence (ChI) is linked with diminished exercise capacity in heart failure with preserved ejection fraction (HFpEF). Although exercise training has shown potential for improving functional capacity, the exercise modality associated with greater functional and chronotropic response (ChR) is not well-known. Additionally, how the ChR from different exercise modalities mediates functional improvement remains to be determined. This study aimed to evaluate the effect of three different exercise programs over current guideline recommendations on peak oxygen consumption (peakVO<sub>2</sub>) in patients with ChI HFpEF phenotype.</p></div><div><h3>Methods and results</h3><p>In this randomized clinical trial, 80 stable symptomatic patients with HFpEF and ChI (NYHA class II-III/IV) are randomized (1:1:1:1) to receive: a) a 12-week program of supervised aerobic training (AT), b) AT and low to moderate-intensity strength training, c)AT and moderate to high-intensity strength training, or d) guideline-based physical activity and exercise recommendations. The primary endpoint is 12-week changes in peakVO<sub>2</sub>. The secondary endpoints are 12-week changes in ChR, 12-week changes in quality of life, and how ChR changes mediate changes in peakVO<sub>2</sub>. A mixed-effects model for repeated measures will be used to compare endpoint changes. The mean age is 75.1 ± 7.2 years, and most patients are women (57.5 %) in New York Heart Association functional class II (68.7 %). The mean peakVO<sub>2</sub>, percent of predicted peakVO<sub>2</sub>, and ChR are 11.8 ± 2.6 mL/kg/min, 67.2 ± 14.7 %, and 0.39 ± 0.16, respectively. No significant baseline clinical differences between arms are found.</p></div><div><h3>Conclusions</h3><p>Training-HR will evaluate the effects of different exercise-based therapies on peakVO<sub>2</sub>, ChR, and quality of life in patients with ChI HFpEF phenotype.</p></div><div><h3>Clinical trial registration</h3><p>ClinicalTrials.gov (NCT05649787).</p></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 12","pages":"Article 102839"},"PeriodicalIF":3.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-04DOI: 10.1016/j.cpcardiol.2024.102834
FNU Venjhraj , Ravi Das , Naren Kumar Matlani , Meva Ram
{"title":"Response to “Racial disparities in trend, clinical characteristics and outcomes in takotsubo syndrome”","authors":"FNU Venjhraj , Ravi Das , Naren Kumar Matlani , Meva Ram","doi":"10.1016/j.cpcardiol.2024.102834","DOIUrl":"10.1016/j.cpcardiol.2024.102834","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 12","pages":"Article 102834"},"PeriodicalIF":3.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Standard Modifiable Cardiovascular Risk Factors (SMuRF) such as hypertension, diabetes mellitus, hyperlipidemia, and smoking have long been established in the etiology of atherosclerotic disease. We evaluate in-hospital outcomes of female STEMI patients without these risk factors.
Methods
The National Inpatient Sample databases (2016 to 2021) were queried to identify STEMI admissions as a principal diagnosis using ICD 10 codes. Patients with a history of coronary artery disease, myocardial infarction, coronary bypass graft, percutaneous coronary intervention, takotsubo cardiomyopathy, cocaine abuse, and spontaneous coronary dissection and males were excluded from our study population. A final study population aged >18 years was divided into cohorts of SMuRF and SMuRF-less based on the presence of ≥1 risk factor. Multivariate logistic regression model adjusting for baseline characteristics and comorbidities. The primary outcome was in-hospital mortality. The secondary outcomes are STEMI-related complications and the use of mechanical circulatory support devices.
Results
200,980 patients were identified. 187,776 (93.4 %) patients were identified as having ≥1 SMuRF, and 13,205 (6.6 %) patients were SMuRF-less. Compared to SMuRF patients, SMuRF-less patients are more likely to be white (75.6 % vs. 73.1 %, p < 0.01) and older median age (69 years [IQR: 58–78] vs 67 years [IQR: 57–81], p < 0.01). In comparing co-morbidities, SMuRF-less patients were less likely to have heart failure (28.0 % vs. 23.4 %, p < 0.01), atrial fibrillation/flutter (16.1 % vs. 14.6 %, p = 0.03), chronic pulmonary disease (18.9 % vs. 9.5 %, p < 0.01), obesity (20.7 % vs. 9.2 %, p < 0.01) and aortic disease (1.1 % vs. 0.6 %, p < 0.01). They were however more likely to have dementia (6.9 % vs. 5.7 %, p < 0.01). In evaluating outcomes, SMuRF-less patients had higher in-hospital mortality (aOR 3.2 [95 % CI, 2.9–3.6]; p < 0.01), acute heart failure (aOR 1.6 [95 % CI, 1.4–1.8]; p < 0.01), acute kidney injury (aOR 1.8 [95 % CI, 1.7–2.1]; p < 0.01), and Intra-aortic balloon pump (aOR 1.7 [95 % CI, 1.5–1.9]; p < 0.01). Predictors of higher mortality in SMuRF-less patients include chronic liver disease (OR 6.8, CI 2.4–19.4, p < 0.01), and Hispanic race (OR 1.62, CI 1.1–2.5, p < 0.01). We also found that SMuRF-less patients were less likely to undergo coronary angiography (aOR 0.5 [95 % CI, 0.4–0.5]; p < 0.01) and percutaneous coronary intervention (aOR 0.7 [95 % CI, 0.6–0.8]; p < 0.01).
Conclusion
Female SMuRF-less patients presenting with STEMI have worse in-hospital outcomes when compared to patients with ≥1SMuRF.
{"title":"Characteristics and in-hospital outcomes of female patients presenting with ST-segment-elevation myocardial infarction without standard modifiable cardiovascular risk factors","authors":"Garba Rimamskep Shamaki MD , Chiwoneso Beverley Tinago PhD, MPH, CHES , Chibuike Charles Agwuegbo MD , Jaskomal Phagoora MS , Tamunoinemi Bob-Manuel MD, FACC, RPVI","doi":"10.1016/j.cpcardiol.2024.102830","DOIUrl":"10.1016/j.cpcardiol.2024.102830","url":null,"abstract":"<div><h3>Background</h3><p>Standard Modifiable Cardiovascular Risk Factors (SMuRF) such as hypertension, diabetes mellitus, hyperlipidemia, and smoking have long been established in the etiology of atherosclerotic disease. We evaluate in-hospital outcomes of female STEMI patients without these risk factors.</p></div><div><h3>Methods</h3><p>The National Inpatient Sample databases (2016 to 2021) were queried to identify STEMI admissions as a principal diagnosis using ICD 10 codes. Patients with a history of coronary artery disease, myocardial infarction, coronary bypass graft, percutaneous coronary intervention, takotsubo cardiomyopathy, cocaine abuse, and spontaneous coronary dissection and males were excluded from our study population. A final study population aged >18 years was divided into cohorts of SMuRF and SMuRF-less based on the presence of ≥1 risk factor. Multivariate logistic regression model adjusting for baseline characteristics and comorbidities. The primary outcome was in-hospital mortality. The secondary outcomes are STEMI-related complications and the use of mechanical circulatory support devices.</p></div><div><h3>Results</h3><p>200,980 patients were identified. 187,776 (93.4 %) patients were identified as having ≥1 SMuRF, and 13,205 (6.6 %) patients were SMuRF-less. Compared to SMuRF patients, SMuRF-less patients are more likely to be white (75.6 % vs. 73.1 %, <em>p</em> < 0.01) and older median age (69 years [IQR: 58–78] vs 67 years [IQR: 57–81], <em>p</em> < 0.01). In comparing co-morbidities, SMuRF-less patients were less likely to have heart failure (28.0 % vs. 23.4 %, <em>p</em> < 0.01), atrial fibrillation/flutter (16.1 % vs. 14.6 %, <em>p</em> = 0.03), chronic pulmonary disease (18.9 % vs. 9.5 %, <em>p</em> < 0.01), obesity (20.7 % vs. 9.2 %, <em>p</em> < 0.01) and aortic disease (1.1 % vs. 0.6 %, <em>p</em> < 0.01). They were however more likely to have dementia (6.9 % vs. 5.7 %, <em>p</em> < 0.01). In evaluating outcomes, SMuRF-less patients had higher in-hospital mortality (aOR 3.2 [95 % CI, 2.9–3.6]; <em>p < 0.01</em>), acute heart failure (aOR 1.6 [95 % CI, 1.4–1.8]; <em>p < 0.01</em>), acute kidney injury (aOR 1.8 [95 % CI, 1.7–2.1]; <em>p < 0.01</em>), and Intra-aortic balloon pump (aOR 1.7 [95 % CI, 1.5–1.9]; <em>p < 0.01</em>). Predictors of higher mortality in SMuRF-less patients include chronic liver disease (OR 6.8, CI 2.4–19.4, <em>p</em> < 0.01), and Hispanic race (OR 1.62, CI 1.1–2.5, <em>p</em> < 0.01). We also found that SMuRF-less patients were less likely to undergo coronary angiography (aOR 0.5 [95 % CI, 0.4–0.5]; <em>p < 0.01</em>) and percutaneous coronary intervention (aOR 0.7 [95 % CI, 0.6–0.8]; <em>p < 0.01</em>).</p></div><div><h3>Conclusion</h3><p>Female SMuRF-less patients presenting with STEMI have worse in-hospital outcomes when compared to patients with ≥1SMuRF.</p></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"49 12","pages":"Article 102830"},"PeriodicalIF":3.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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