Current Problems in Cardiology最新文献

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Developing a tool to predict the likelihood of undergoing orthotopic cardiac transplant from the urgent waitlist - a single centre UK experience. 开发一种工具，以预测接受原位心脏移植的可能性从紧急候补名单-单一中心英国的经验。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.cpcardiol.2025.103147

Mansimran Singh Dulay, Rishi Patel, Winston Banya, Dharani Yogasivam, Ramey Assaf, Nahal Raza, Andrew Morley-Smith, Fernando Riesgo-Gil, Owais Dar

Background: Orthotopic Cardiac Transplantation (OCTx) improves survival in advanced heart failure. Currently, a tool in United Kingdom from NHS Blood and Transplant (NHSBT) helps predict likelihood of OCTx from waitlist. However, it does not use predictive variables such as age, or Human Leukocyte Antibody (HLA%). We aimed to develop OCTx predictive models incorporating known prognostic variables at 3-, 6-, 9- and 12-months.

Methods: All patients who were urgent-listed for OCTx at Harefield Hospital between 2014 and 2018 (n = 125) were analysed. Variables included age, gender, blood group (BG), midline sternotomy, ventricular assist device (VAD), body mass index (BMI) and HLA%. Multivariable logistic regression models were constructed following internal validation per timepoint. A separate validation dataset was collected using 52 patients transplanted between 2019 and 2023, to compare model effectiveness against the current NHSBT tool.

Results: At 3-months, variables included were age, gender, sternotomy, BG O and HLA%=0, with model area under curve (AUC) of 0.74 (0.66-0.83 95 % confidence interval [CI]). 6-month model included variables age, gender, BG O, sternotomy, BMI and HLA%=0, model AUC of 0.80 (0.72-0.89 95 % CI). 9-month model used age, BG O, VAD, BMI and HLA%=0, giving an AUC of 0.80 (0.71-0.89 95 % CI). The final 12-month model included midline sternotomy, BMI and HLA%=0 and HLA%=1-24, with AUC 0.78 (0.68-0.88 95 % CI). Our predictive models recorded an 85 % win-ratio compared to the NHSBT tool.

Conclusion: We were able to develop models to predict urgent OCTx, with greater accuracy than the currently available tool. Multicentre external validation would help enable its wider implementation.

背景：原位心脏移植（OCTx）可提高晚期心力衰竭患者的生存率。目前，英国NHS血液和移植（NHSBT）的一种工具可以帮助预测候补名单中OCTx的可能性。然而，它没有使用预测变量，如年龄，或人类白细胞抗体（HLA%）。我们的目标是在3、6、9和12个月时建立包含已知预后变量的OCTx预测模型。方法：分析2014-2018年在哈雷菲尔德医院（Harefield Hospital）紧急登记的所有OCTx患者（n=125）。变量包括年龄、性别、血型（BG）、胸骨中线切开术、心室辅助装置（VAD）、体重指数（BMI）和HLA%。在每个时间点进行内部验证后，构建多变量逻辑回归模型。收集了2019-2023年间移植的52例患者的单独验证数据集，以比较模型与当前NHSBT工具的有效性。结果：3个月时，变量包括年龄、性别、胸骨切开术、BG 0、HLA%=0，模型曲线下面积（AUC）为0.74（95%可信区间[CI] 0.66 ~ 0.83）。6个月模型变量包括年龄、性别、BG、胸骨切开术、BMI、HLA%=0，模型AUC为0.80 （95% CI为0.72 ~ 0.89）。9月龄模型采用年龄、BG 0、VAD、BMI和HLA%=0， AUC为0.80 （95% CI 0.71 ~ 0.89）。最终12个月模型包括胸骨中线切开术，BMI和HLA%=0, HLA%=1-24， AUC为0.78 （95% CI为0.68-0.88）。与NHSBT工具相比，我们的预测模型的胜率为85%。结论：我们能够开发预测紧急OCTx的模型，比目前可用的工具具有更高的准确性。多中心外部验证将有助于其更广泛的实施。

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引用次数: 0

Inflammation, abdominal aortic aneurysm enlargement and rupture. Lessons learned from the Covid19 pandemic. 炎症，腹主动脉瘤增大和破裂。从2019冠状病毒病大流行中吸取的教训。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.cpcardiol.2025.103151

Antonio V Sterpetti, Francesca Miceli, Alessia Di Girolamo, Antonio Bozzani, Vittorio Arici, Marta Ascione, Luca Di Marzo

Patients with moderate-severe COVID19 infection suffer from several cardiovascular diseases: heart failure (3 %-33 %), myocardial ischemia (0.9 %-11 %), ventricular dysfunction (10 %-47 %), arrhythmias (9 %-17 %), venous thrombo-embolism (25 %) and arterial thrombosis (1 %-3 %). Although intracranial and coronary arterial aneurysms have been described in adults and children with COVID19, few reports have correlated COVID19 infection and sudden degeneration of aortic aneurysms and dissections. We analyzed the risk factor for enlargement and rupture of aortic aneurysms in patrients with moderate-severe COVID19 infection. Several COVID19 related mechanisms may impact aortic aneurysm progression: increased elastin and collagen digestion by enzymes triggered by viral spike proteins in ACE2-negative myeloid cells and/or by inflammatory cytokines; hypoxemia related to thrombosis of micro vessels of the aneurismal wall; dysregulation of the immune system. Patients with known arterial aneurysm may be at risk for sudden increase of dimensions and rupture during moderate-severe COVID19 infection.

中重度covid - 19感染患者伴有多种心血管疾病：心力衰竭（3%-33%）、心肌缺血（0.9%-11%）、心室功能障碍（10%-47%）、心律失常（9%-17%）、静脉血栓栓塞（25%）和动脉血栓形成（1%-3%）。虽然在成人和儿童中已经描述了covid - 19颅内和冠状动脉动脉瘤，但很少有报道将covid - 19感染与主动脉瘤的突然变性和夹层联系起来。我们分析了中重度covid - 19感染患者主动脉瘤扩大和破裂的危险因素。几种与covid - 19相关的机制可能影响主动脉瘤的进展：ace2阴性髓细胞中病毒刺突蛋白触发的酶和/或炎症细胞因子增加了弹性蛋白和胶原蛋白的消化；低氧血症与动脉瘤壁微血管血栓形成的关系免疫失调免疫系统失调已知动脉瘤患者在中重度感染期间可能面临尺寸突然增大和破裂的风险。

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引用次数: 0

Interleukin-36: a novel therapeutic target for atherosclerosis 白细胞介素-36：动脉粥样硬化的新治疗靶点。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-28 DOI: 10.1016/j.cpcardiol.2025.103187

Shuting Tan , Yongheng Li , Zhenshuai Yao , Xiao Xu , Jin Wang , Xiaofang Zhu , Pingping He

Cardiovascular diseases remain the foremost cause of global morbidity and mortality, with atherosclerosis serving as the pathological basis for most related disorders. Despite the clinical benefits of statin therapy, a substantial residual risk persists, underscoring the need to explore novel therapeutic targets. Interleukin-36 (IL-36), a member of the interleukin-1 family, has emerged as a key regulator of immune and inflammatory responses. Beyond its established roles in tissue repair, host defense, and inflammatory signaling, IL-36 has been increasingly implicated in cardiovascular pathology, including myocardial infarction, ischemic injury, and myocarditis. Recent evidence highlights its pro-atherogenic functions mediated through sustained vascular inflammation, abnormal angiogenesis, impaired cholesterol metabolism, excessive neutrophil extracellular trap formation, and disrupted autophagy. These findings collectively suggest that IL-36 not only contributes to the initiation and progression of atherosclerosis but also holds promise as a potential therapeutic target. This review summarizes recent progress on the regulatory roles and signaling mechanisms of IL-36, emphasizing its contribution to atherogenesis.

心血管疾病仍然是全球发病率和死亡率的首要原因，动脉粥样硬化是大多数相关疾病的病理基础。尽管他汀类药物治疗具有临床益处，但仍存在大量残留风险，因此需要探索新的治疗靶点。白细胞介素-36 （IL-36）是白细胞介素-1家族的一员，已成为免疫和炎症反应的关键调节因子。除了在组织修复、宿主防御和炎症信号传导方面的既定作用外，IL-36也越来越多地参与心血管病理，包括心肌梗死、缺血性损伤和心肌炎。最近的证据表明，它的促动脉粥样硬化功能通过持续的血管炎症、血管生成异常、胆固醇代谢受损、中性粒细胞胞外陷阱过度形成和自噬破坏介导。这些发现共同表明，IL-36不仅有助于动脉粥样硬化的发生和进展，而且还有望成为潜在的治疗靶点。本文综述了IL-36的调控作用和信号机制的最新进展，重点介绍了其在动脉粥样硬化中的作用。

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引用次数: 0

Title Page 标题页

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/S0146-2806(25)00196-3

引用次数: 0

Design and methods of the AUTOMATED-WCT trial: evaluating machine learning–based ECG support for WCT interpretation 自动WCT试验的设计和方法：评估基于机器学习的心电图对WCT解释的支持。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/j.cpcardiol.2025.103186

Adam M. May MD , Sarah LoCoco MD , Krasimira M. Mikhova MD , Rugheed Ghadban MD , Phillip S. Cuculich MD , Daniel H. Cooper MD , Thomas M. Maddox MD, MSc , Prashanth Thakkar MD , Elena Deych MS , Ian Rowlandson MS , Alexander Siotis MD , Nandan Anavaker MD , Peter A. Noseworthy MD , Anthony Kashou MD

Background

Distinguishing wide complex tachycardia (WCT) as ventricular tachycardia (VT) or supraventricular WCT (SWCT) is critical yet challenging. Manual ECG algorithms require substantial expertise and are inconsistently applied, and contemporary computerized ECG interpretation (CEI) systems often return only a generic “wide complex tachycardia” label. Novel machine learning–based ECG models (Solo Model, Paired Model) can provide a VT probability or a direct VT/SWCT classification, but they have not yet been evaluated in a prospective, randomized, workflow-integrated trial.

Design

We will conduct a prospective, multicenter, investigator-initiated, open-label, four-arm randomized reader trial. Physicians (attendings and fellows in cardiology, emergency medicine, critical care) will be randomized 1:1:1:1 to: (1) Control #1—WCT ECG only; (2) Control #2—WCT ECG + baseline ECG; (3) Solo Model—WCT ECG + model output (no baseline ECG); (4) Paired Model—WCT ECG + baseline ECG + model output. Each participant will interpret 20 adjudicated WCT ECGs on a secure virtual platform, classify rhythm, rate confidence and percieved usefulness, and indicate likely next steps in clinical management. Primary endpoint: WCT classification accuracy. Secondary endpoints: sensitivity, specificity, PPV, NPV, F1 score, time to diagnosis, interpreation confidence, perceived usefulness, and intended management after diagnosis.

Conclusion

The AUTOMATED-WCT Trial will be the first randomized, multicenter evidence on machine learning–based ECG decision support for WCT differentiation.

背景：区分宽复杂性心动过速（WCT）为室性心动过速（VT）或室上性心动过速（SWCT）是关键但具有挑战性的。手动心电算法需要大量的专业知识，并且应用不一致，而现代计算机心电解释（CEI）系统通常只返回通用的“广泛性复杂心动过速”标签。新的基于机器学习的ECG模型（单独模型，配对模型）可以提供VT概率或直接VT/SWCT分类，但尚未在前瞻性，随机，集成工作流程的试验中进行评估。设计：我们将进行一项前瞻性、多中心、研究者发起、开放标签、四组随机读者试验。医生（心脏病学、急诊医学、重症监护的主治医师和研究员）将以1:1:1:1的比例随机分配到：(1)对照#1-仅wct心电图；(2)对照#2- wct心电图 + 基线心电图；(3) Solo模型- wct心电图 + 模型输出（无基线心电图）；(4)配对模型- wct心电图 + 基线心电图 + 模型输出。每个参与者将在一个安全的虚拟平台上解释20个经判定的WCT心电图，对节律进行分类，评估信心和感知的有用性，并指出临床管理的下一步可能的步骤。主要终点：WCT分类准确率。次要终点：敏感性、特异性、PPV、NPV、F1评分、诊断时间、解释置信度、感知有用性和诊断后的预期管理。结论：自动WCT试验将是首个基于机器学习的ECG决策支持WCT鉴别的随机、多中心证据。

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引用次数: 0

Guidelines for Authors 作者指南

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/S0146-2806(25)00203-8

引用次数: 0

Nocturnal hypertension and cardiovascular events: risk analysis using propensity score matching 夜间高血压和心血管事件：使用倾向评分匹配的风险分析。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/j.cpcardiol.2025.103185

Joaquin Perea , Daniel Martin , Marlon Ruiz Holguín , Diego Arluna , Oscar Gomez , Santiago Simone , Alvaro Sosa Liprandi , Maria Ines Sosa Liprandi

Background

Nocturnal hypertension (NHT) is associated with major adverse cardiovascular events (MACE) and heart failure (HF), and remains an area of growing interest, with evidence suggesting a differential impact compared to daytime hypertension (DTH).

Objectives

To evaluate the relationship between NHT and the risk of cardiovascular events, independently of daytime blood pressure.

Methods

We conducted an observational study based on a continuous registry of patients who underwent ambulatory blood pressure monitoring at a tertiary care center. Propensity score matching (1:1) was applied using relevant clinical factors to ensure comparability between groups. The primary outcome was the composite of MACE and HF. Cox regression and cubic spline models were used to explore non-linear associations and identify critical thresholds.

Results

After matching, 1,392 patients were analyzed (691 per group). In adjusted models, nocturnal systolic blood pressure was significantly associated with increased risk of MACE/HF (HR 1.04; 95 % CI: 1.01–1.07), whereas daytime systolic pressure showed no association (HR 0.98; 95 % CI: 0.95–1.01). In the multivariable model, NHT maintained its adverse effect (HR 1.03; 95 % CI: 1.01–1.04), together with other established clinical predictors. Risk curves demonstrated a non-linear association, with a significant increase in risk above 148 mmHg of nocturnal systolic blood pressure.

Conclusions

NHT independently increases the risk of cardiovascular events and provides prognostic thresholds that may improve risk stratification.

背景：夜间高血压（NHT）与主要不良心血管事件（MACE）和心力衰竭（HF）相关，并且仍然是一个越来越受关注的领域，有证据表明与白天高血压（DTH）相比，夜间高血压（NHT）的影响不同。目的：评估NHT与心血管事件风险之间的关系，独立于白天血压。方法：我们进行了一项观察性研究，该研究基于在三级保健中心接受动态血压监测的患者的连续登记。采用相关临床因素进行倾向评分匹配（1:1），确保组间可比性。主要终点是MACE和HF的综合结果。Cox回归和三次样条模型用于探索非线性关联和确定临界阈值。结果：匹配后，共分析1392例患者（每组691例）。在调整后的模型中，夜间收缩压与MACE/HF风险增加显著相关（HR 1.04; 95% CI: 1.01-1.07），而白天收缩压与MACE/HF风险增加无相关性（HR 0.98; 95% CI: 0.95-1.01）。在多变量模型中，NHT与其他已建立的临床预测因子一起保持其不良反应（HR 1.03; 95% CI: 1.01-1.04）。风险曲线显示出非线性关系，夜间收缩压高于148 mmHg时风险显著增加。结论：NHT单独增加心血管事件的风险，并提供可能改善风险分层的预后阈值。

{"title":"Nocturnal hypertension and cardiovascular events: risk analysis using propensity score matching","authors":"Joaquin Perea , Daniel Martin , Marlon Ruiz Holguín , Diego Arluna , Oscar Gomez , Santiago Simone , Alvaro Sosa Liprandi , Maria Ines Sosa Liprandi","doi":"10.1016/j.cpcardiol.2025.103185","DOIUrl":"10.1016/j.cpcardiol.2025.103185","url":null,"abstract":"<div><h3>Background</h3><div>Nocturnal hypertension (NHT) is associated with major adverse cardiovascular events (MACE) and heart failure (HF), and remains an area of growing interest, with evidence suggesting a differential impact compared to daytime hypertension (DTH).</div></div><div><h3>Objectives</h3><div>To evaluate the relationship between NHT and the risk of cardiovascular events, independently of daytime blood pressure.</div></div><div><h3>Methods</h3><div>We conducted an observational study based on a continuous registry of patients who underwent ambulatory blood pressure monitoring at a tertiary care center. Propensity score matching (1:1) was applied using relevant clinical factors to ensure comparability between groups. The primary outcome was the composite of MACE and HF. Cox regression and cubic spline models were used to explore non-linear associations and identify critical thresholds.</div></div><div><h3>Results</h3><div>After matching, 1,392 patients were analyzed (691 per group). In adjusted models, nocturnal systolic blood pressure was significantly associated with increased risk of MACE/HF (HR 1.04; 95 % CI: 1.01–1.07), whereas daytime systolic pressure showed no association (HR 0.98; 95 % CI: 0.95–1.01). In the multivariable model, NHT maintained its adverse effect (HR 1.03; 95 % CI: 1.01–1.04), together with other established clinical predictors. Risk curves demonstrated a non-linear association, with a significant increase in risk above 148 mmHg of nocturnal systolic blood pressure.</div></div><div><h3>Conclusions</h3><div>NHT independently increases the risk of cardiovascular events and provides prognostic thresholds that may improve risk stratification.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 12","pages":"Article 103185"},"PeriodicalIF":3.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Information for Readers 读者资讯

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/S0146-2806(25)00197-5

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Editor’s Message 编辑器’的消息

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-25 DOI: 10.1016/S0146-2806(25)00202-6

引用次数: 0

Value of extreme left axis deviation in patients with complete left bundle branch block 完全性左束支传导阻滞患者左轴极值偏移的价值。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology

Pub Date : 2025-09-10 DOI: 10.1016/j.cpcardiol.2025.103174

Guido Vannoni MD, Carlos D. Labadet MD, Giuliana Caminotti MD, Bárbara Zambudio MD, Juan M. Fiamengo Tch, Lucas N. Campana MD, María V. Vannoni MD, Gerardo M. Marambio MD, Jorge A. Lax MD, Juan A. Gagliardi MD, PhD

Introduction

Complete left bundle branch block (LBBB) is associated with increased risk of cardiovascular events. The value of extreme deviation of the QRS axis to the left (LAD) in the context of LBBB is controversial.

Objective

To evaluate whether LAD (-45°) in patients with LBBB is a marker of systolic dysfunction and ventricular remodeling.

Material and methods

Cross-sectional cohort study including 102 patients with LBBB who underwent echocardiography to assess left ventricular (LV) diameters, wall thickness and ejection fraction (EF).

Results

Mean age was 67.9 ± 13 years. 48 % were women. 80.4 % met Strauss criteria for LBBB and 28.4 % had LAD. The LAD group showed lower EF (32.2 ± 12 % vs. 46.7 ± 17 %, p = 0.00009) and higher LV end-diastolic diameter index (34.8 ± 9 vs. 30.9 ± 6, p = 0.011). LAD had 45 % sensitivity, 88 % specificity, positive predictive value of 0.79 and negative predictive value of 0.62 for identifying reduced EF. Cardiomyopathy diagnosis was more frequent in the LAD group (93.1 % vs. 61.6 %; p = 0.0016). LV hypertrophy prevalence was similar between groups, but LAD patients had higher prevalence of eccentric LV hypertrophy.

Conclusion

In LBBB, LAD (-45°) identifies patients with worse systolic function, greater degree of LV dilatation, and more eccentric hypertrophy. Additionally, cardiomyopathy prevalence was higher in this population.

完全性左束支阻滞（LBBB）与心血管事件风险增加相关。在LBBB的情况下，QRS轴向左极端偏差（LAD）的值是有争议的。目的：评价LBBB患者LAD（-45°）是否为收缩功能障碍和心室重构的标志。材料和方法：横断面队列研究包括102例LBBB患者，接受超声心动图评估左室（LV）直径、壁厚和射血分数（EF）。结果：平均年龄67.9±13岁。48%是女性。80.4%符合Strauss LBBB标准，28.4%有LAD。LAD组EF降低（32.2±12%比46.7±17%,p=0.00009），左室舒张末期内径指数升高（34.8±9比30.9±6,p=0.011）。LAD对EF的敏感性为45%，特异性为88%，阳性预测值为0.79，阴性预测值为0.62。LAD组心肌病的诊断频率更高（93.1%比61.6%;p=0.0016）。各组间左室肥厚发生率相似，但LAD患者偏心性左室肥厚发生率较高。结论：在LBBB中，LAD（-45°）识别收缩功能较差、左室扩张程度较大、偏心性肥厚较多的患者。此外，该人群的心肌病患病率较高。

{"title":"Value of extreme left axis deviation in patients with complete left bundle branch block","authors":"Guido Vannoni MD, Carlos D. Labadet MD, Giuliana Caminotti MD, Bárbara Zambudio MD, Juan M. Fiamengo Tch, Lucas N. Campana MD, María V. Vannoni MD, Gerardo M. Marambio MD, Jorge A. Lax MD, Juan A. Gagliardi MD, PhD","doi":"10.1016/j.cpcardiol.2025.103174","DOIUrl":"10.1016/j.cpcardiol.2025.103174","url":null,"abstract":"<div><h3>Introduction</h3><div>Complete left bundle branch block (LBBB) is associated with increased risk of cardiovascular events. The value of extreme deviation of the QRS axis to the left (LAD) in the context of LBBB is controversial.</div></div><div><h3>Objective</h3><div>To evaluate whether LAD (-45°) in patients with LBBB is a marker of systolic dysfunction and ventricular remodeling.</div></div><div><h3>Material and methods</h3><div>Cross-sectional cohort study including 102 patients with LBBB who underwent echocardiography to assess left ventricular (LV) diameters, wall thickness and ejection fraction (EF).</div></div><div><h3>Results</h3><div>Mean age was 67.9 ± 13 years. 48 % were women. 80.4 % met Strauss criteria for LBBB and 28.4 % had LAD. The LAD group showed lower EF (32.2 ± 12 % vs. 46.7 ± 17 %, p = 0.00009) and higher LV end-diastolic diameter index (34.8 ± 9 vs. 30.9 ± 6, p = 0.011). LAD had 45 % sensitivity, 88 % specificity, positive predictive value of 0.79 and negative predictive value of 0.62 for identifying reduced EF. Cardiomyopathy diagnosis was more frequent in the LAD group (93.1 % vs. 61.6 %; p = 0.0016). LV hypertrophy prevalence was similar between groups, but LAD patients had higher prevalence of eccentric LV hypertrophy.</div></div><div><h3>Conclusion</h3><div>In LBBB, LAD (-45°) identifies patients with worse systolic function, greater degree of LV dilatation, and more eccentric hypertrophy. Additionally, cardiomyopathy prevalence was higher in this population.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 11","pages":"Article 103174"},"PeriodicalIF":3.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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