European Journal of Oncology Nursing最新文献_第10页

Comparative efficacy of exercise interventions for managing cancer-related symptoms and enhancing quality of life: A systematic review and network meta-analysis 运动干预对控制癌症相关症状和提高生活质量的比较疗效：系统回顾和网络荟萃分析

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.ejon.2025.103022

Yuxin Wang , Ying Wang ([email protected]) , Yue Cui , Weiwei Su , Yajing Xue

Purpose

The objective of this study was to evaluate and compare the efficacy of available exercises for cancer-related symptoms in cancer survivors to provide references for healthcare professionals and clinicians.

Methods

This study was registered on PROSPERO. PubMed, Cochrane Library, Web of Science, EMBASE, and PsycInfo were searched from their inception to 16 August 2024. Reference lists of included trials and related reviews, the U.S. National Library of Medicine Clinical Trial Registry Platform and the World Health Organization International Clinical Trials Registry Platform were also searched. Study selection, data extraction and risk of assessment were independently performed by two researchers. STATA software version 16.0 was adopted to conduct the network meta-analysis.

Results

A total of 277 trials with 21,018 participants were included. The surface under the cumulative ranking curve values indicated that the best exercise intervention for fatigue was aerobic exercise (75.6 %), for quality of life (84.5 %) and pain (77.2 %) was resistance exercise, for anxiety was mind-body exercise (89.6 %), for depression was multi-component exercise (93.3 %). Values of the Surface Under the Cumulative Ranking Curve indicated that the best exercise for fatigue was aerobic exercise (75.6 %); for quality of life (84.5 %) and pain (77.2 %), it was resistance exercise; for anxiety, it was mind-body exercise (89.6 %); and for depression, it was multi-component exercise (93.3 %).

Conclusions

Resistance exercise has the highest probability of being the optimal exercise type for reducing quality of life and sleep disturbances. In the future, more strictly designed trials are needed to verify the conclusions of this network meta-analysis.

目的本研究的目的是评估和比较现有的运动对癌症幸存者癌症相关症状的疗效，为医疗保健专业人员和临床医生提供参考。方法本研究在PROSPERO上注册。PubMed, Cochrane Library, Web of Science， EMBASE和PsycInfo从其成立到2024年8月16日进行了检索。还检索了纳入试验和相关综述的参考列表、美国国家医学图书馆临床试验注册平台和世界卫生组织国际临床试验注册平台。研究选择、数据提取和风险评估由两位研究者独立完成。采用STATA软件16.0版本进行网络meta分析。结果共纳入277项试验，21,018名受试者。累积排序曲线下的表面值显示，对疲劳的最佳运动干预为有氧运动（75.6%），对生活质量的最佳运动干预为抵抗运动（84.5%），对疼痛的最佳运动干预为抵抗运动（77.2%），对焦虑的最佳运动干预为身心运动（89.6%），对抑郁的最佳运动干预为多成分运动（93.3%）。累积排序曲线下的曲面值表明，有氧运动是治疗疲劳的最佳运动（75.6%）；生活质量（84.5%）和疼痛（77.2%）以阻力运动为主；对于焦虑，是身心运动（89.6%）；而对于抑郁症，则是多组分运动（93.3%）。结论抗阻运动最有可能成为减少生活质量和睡眠障碍的最佳运动类型。在未来，需要更严格设计的试验来验证该网络荟萃分析的结论。

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引用次数: 0

German cancer nurses and occupational exposure to cytotoxic drugs: A cross-sectional study with a mixed-methods approach 德国癌症护士和职业暴露于细胞毒性药物：一项混合方法的横断面研究。

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.ejon.2025.103014

Matthias Naegele

Purpose

Cytotoxic drugs (CDs) pose considerable occupational health risks to oncology nurses due to their carcinogenic, genotoxic, and teratogenic properties. This study investigates the prevalence of CD-related symptoms among German oncology nurses and assesses the implementation of safety measures in clinical practice.

Methods

A mixed-methods, cross-sectional survey was conducted among 400 oncology nurses attending 14 CD safety training courses in Germany. Quantitative data captured demographics, symptom prevalence, and workplace safety measures, while qualitative data were derived from open-ended questions on specific exposure events. Descriptive statistics and qualitative content analysis (Mayring method) were applied.

Results

One-third (33.75 %) of nurses reported symptoms attributed to CD handling, mainly skin reactions (51.58 %), headaches (41.48 %), and altered taste sensations (28.15 %). Qualitative data revealed that exposure mainly occurred during CD administration (35 %) and was linked to improper management (56 %), especially through defective or incorrectly handled infusion systems. Protective measures were inconsistently applied: while 80.47 % of institutions had SOPs, 64.12 % provided safety training, no site implemented all recommended measures. Only 60.42 % of the nurses used cytotoxic-proof gloves; other PPE components were rarely used. Subgroup analyses indicated that nurses with CD-related symptoms were more likely to work in settings with fewer technical and organizational safeguards.

Conclusion

This study highlights critical gaps in CD safety protocols in German oncology practice. Inadequate training, insufficient technical controls, and inconsistent PPE use contribute to occupational exposure risks. Enhancing protective strategies, promoting a strong safety culture, and improving institutional accountability are essential to safeguard oncology nurses and reduce CD related health risks.

目的：细胞毒性药物（CDs）因其致癌性、遗传毒性和致畸性，给肿瘤科护士带来了相当大的职业健康风险。本研究调查了德国肿瘤科护士cd相关症状的患病率，并评估了临床实践中安全措施的实施情况。方法：对在德国参加14个CD安全培训课程的400名肿瘤科护士进行混合方法横断面调查。定量数据包括人口统计、症状流行率和工作场所安全措施，而定性数据来自关于特定暴露事件的开放式问题。采用描述性统计和定性内容分析（Mayring法）。结果：三分之一（33.75%）的护士报告了与CD处理有关的症状，主要是皮肤反应（51.58%）、头痛（41.48%）和味觉改变（28.15%）。定性数据显示，暴露主要发生在给药期间（35%），与管理不当有关（56%），特别是通过有缺陷或处理不当的输液系统。防护措施执行不一致：80.47%的机构有标准操作规程，64.12%的机构提供安全培训，没有一个场所执行所有建议的措施。只有60.42%的护士使用细胞毒手套；很少使用其他个人防护装备组件。亚组分析表明，有cd相关症状的护士更有可能在技术和组织保障较少的环境中工作。结论：这项研究突出了德国肿瘤学实践中CD安全协议的关键差距。培训不足、技术控制不足和个人防护装备使用不一致导致职业暴露风险。加强保护策略，促进强大的安全文化，改善机构问责制对于保护肿瘤护士和减少与乳糜泻相关的健康风险至关重要。

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引用次数: 0

Experiences, support needs, and coping strategies of women with early-stage breast cancer in Singapore: A qualitative study 新加坡早期乳腺癌患者的经历、支持需求和应对策略：一项定性研究。

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.ejon.2025.103017

Yan Pang , Fong-Seng Lim , Marie Ann Mae En Wong , Samuel Guan-Wei Ow , Minna Pikkarainen , Swee-Ho Lim , Hong-Gu He

Purpose

Despite medical advancements, early-stage breast cancer continues to impose significant emotional, physical and psychosocial strain on women. Understanding their evolving experiences and needs across the cancer trajectory is critical for developing culturally sensitive, patient-centered interventions to enhance quality of life.

Methods

A qualitative exploratory study was conducted with 20 women diagnosed with Stage 0-IIIA breast cancer who had completed curative-intent treatment. Participants were purposively recruited from an outpatient oncology clinic in a public hospital. Semi-structured interviews, guided by Lazarus and Folkman's stress and coping model, were conducted between August 2021 and August 2022. Qualitative data were analyzed thematically, and descriptive statistics summarized participant characteristics.

Results

Four core themes emerged: (i) Initial Reactions to Diagnosis and Treatment Decisions, (ii) Psychosocial and Physical Burdens of the Cancer Experience, (iii) Multidimensional Support Systems, and (iv) Inner Strength and Transformative Coping. Participants reported distress at diagnosis, evolving informational and emotional needs, and significant reliance on emotion- and meaning-focused coping. Cultural and religious beliefs shaped treatment decisions and adjustment. Fear of recurrence, body image concerns, and periods of social withdrawal were common but rarely disclosed to clinicians. Family involvement in decision making was notable, reflecting collectivist values.

Conclusion

Women with early-stage breast cancer in Singapore face complex and evolving psychosocial challenges shaped by sociocultural context. Healthcare professionals should provide timely, tailored information and integrate psychosocial support across the cancer trajectory. Recognizing cultural values, supporting patient autonomy, and involving family appropriately can enhance person-centered and culturally responsive cancer care.

目的：尽管医学取得了进步，但早期乳腺癌继续给妇女带来巨大的情感、身体和心理压力。了解他们在整个癌症发展过程中不断变化的经历和需求，对于开发具有文化敏感性的、以患者为中心的干预措施以提高生活质量至关重要。方法：对20例0-IIIA期乳腺癌患者进行定性探索性研究。参与者是有目的地从公立医院的肿瘤门诊诊所招募的。在Lazarus和Folkman的压力和应对模型的指导下，半结构化访谈于2021年8月至2022年8月进行。定性数据进行主题分析，描述性统计总结参与者特征。结果：出现了四个核心主题：(i)对诊断和治疗决定的初始反应，（ii）癌症经历的心理社会和身体负担，（iii）多维支持系统，以及（iv）内在力量和变革应对。参与者报告了诊断时的痛苦，不断变化的信息和情感需求，以及对以情感和意义为中心的应对的显著依赖。文化和宗教信仰影响了治疗决定和调整。对复发的恐惧、对身体形象的担忧和社交退缩期是常见的，但很少向临床医生披露。家庭参与决策是显著的，反映了集体主义价值观。结论：新加坡早期乳腺癌患者面临着社会文化背景下复杂且不断演变的社会心理挑战。医疗保健专业人员应提供及时、量身定制的信息，并在整个癌症轨迹中整合心理社会支持。认识到文化价值，支持病人自主，并适当地让家庭参与，可以加强以人为本和文化响应的癌症护理。

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引用次数: 0

Effectiveness of computerised cognitive training on cognitive functioning and quality of life in cancer survivors with cancer-related cognitive impairments: A systematic review and meta-analysis 计算机化认知训练对患有癌症相关认知障碍的癌症幸存者的认知功能和生活质量的影响：一项系统综述和荟萃分析

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-13 DOI: 10.1016/j.ejon.2025.103006

Wan Ngee Ang , Si Xian Ng , Siti Umairah Fathul Rahman , Hong-Gu He

Purpose

This systematic review and meta-analysis aimed to synthesise existing evidence of the effectiveness of Computerised Cognitive Training (CCT) in enhancing cognitive functions and quality of life (QOL) in cancer survivors with Cancer-related cognitive impairment (CRCI).

Methods

Eight electronic (CINAHL, Cochrane, Embase, PsycINFO, PubMed, Scopus, ProQuest Social Science Database, Web of Science) and four grey literature databases were searched from inception till December 31, 2023. Two reviewers independently screened and extracted data before appraising the risk of bias and the overall quality of findings. Meta-analyses, sensitivity and subgroup analyses were carried out using the RevMan 7.2.0 Software. Cochrane GRADE assessed the overall quality assessment.

Results

Ten randomised controlled trials (RCTs) involving 949 participants were included. The meta-analyses revealed that CCT was statistically significant, with small effect sizes for improving executive function at follow-up (standardised mean difference (SMD) = 0.26, 95 % CI [0.11, 0.41], P = 0.0008), working memory post-intervention (SMD = 0.25, 95 % CI [0.08, 0.43], P = 0.003), and working memory at follow-up (SMD = 0.30, 95 % CI [0.14, 0.46], P = 0.0003).

Conclusions

CCT exhibited effectiveness in enhancing executive functions (at follow-up) and working memory in Cancer Survivors with CRCI, highlighting its potential as a valuable addition to standard care pathways in oncology settings. Future research should explore expanding CCT delivery to platforms such as mobile phones and tablets to provide critical insights into optimising CT interventions to enhance user engagement.

目的：本系统综述和荟萃分析旨在综合计算机化认知训练（CCT）在增强癌症相关认知障碍（CRCI）癌症幸存者认知功能和生活质量（QOL）方面有效性的现有证据。方法：检索自建库至2023年12月31日的8个电子数据库（CINAHL、Cochrane、Embase、PsycINFO、PubMed、Scopus、ProQuest Social Science Database、Web of Science）和4个灰色文献数据库。在评估偏倚风险和研究结果的整体质量之前，由两名审稿人独立筛选和提取数据。采用RevMan 7.2.0软件进行meta分析、敏感性分析和亚组分析。Cochrane GRADE对整体质量进行评估。结果：纳入10项随机对照试验（RCTs），共949名受试者。meta分析显示，CCT在改善随访时的执行功能（标准化平均差异(SMD) = 0.26, 95% CI [0.11, 0.41], P = 0.0008）、干预后的工作记忆（SMD = 0.25, 95% CI [0.08, 0.43], P = 0.003）和随访时的工作记忆（SMD = 0.30, 95% CI [0.14, 0.46], P = 0.0003）方面具有统计学意义。结论：CCT在增强CRCI癌症幸存者的执行功能（随访）和工作记忆方面表现出有效性，突出了其作为肿瘤学环境中标准治疗途径的有价值补充的潜力。未来的研究应该探索将有条件CT治疗扩展到手机和平板电脑等平台，为优化CT干预措施以提高用户参与度提供关键见解。

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引用次数: 0

The impact of brachytherapy on sexual life in patients with gynecological cancer 近距离放疗对妇科肿瘤患者性生活的影响。

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.ejon.2025.103012

Ergül Aslan , Derya Kaya Şenol , Semiha Akın Eroğlu , Ayşegül Türkmenoğlu , Seda Çağlı Öztürk , Nezihe Seden Küçücük

Purpose

This study was conducted to evaluate the effects of brachytherapy on sexual life in patients diagnosed with gynecological cancer and undergoing brachytherapy.

Methods

This is a descriptive cross-sectional study. The sample consisted of patients who met the inclusion criteria, were diagnosed with cervical or endometrial cancer, applied to the unit for brachytherapy, and were continuing with the treatment. The study was completed with 87 patients who were continuing their treatment during the second assessment and 77 patients during the third assessment.

Results

In this study, at the third month, women experienced significantly higher levels of problems such as loss of sexual desire, avoidance of sexual intercourse, pain during intercourse, changes in sexual life due to brachytherapy, inability to achieve orgasm, and lack of sexual approach from their partner (p < 0.05). In assessments conducted with gynecological cancer patients at the 3rd month after brachytherapy, the total scores of the Female Sexual Function Index (FSFI) and the Sexual Satisfaction Scale for Women (SSS-W) were found to be significantly higher compared to the scores obtained before brachytherapy and at the 6th month after brachytherapy (p < 0.05).

Conclusions

For gynecological cancer patients undergoing brachytherapy, the implementation of not only short-term but also long-term follow-up and supportive rehabilitation programs is critically important for assessing sexual symptoms and maintaining sexual well-being.

目的：探讨近距离放疗对妇科肿瘤患者性生活的影响。方法：这是一项描述性横断面研究。样本包括符合纳入标准的患者，诊断为宫颈癌或子宫内膜癌，申请近距离放射治疗，并继续治疗。研究结束时，87名患者在第二次评估期间继续治疗，77名患者在第三次评估期间继续治疗。结果：在这项研究中，在第三个月，女性经历了明显更高水平的问题，如性欲丧失，避免性交，性交时疼痛，近距离治疗导致的性生活改变，无法达到性高潮，以及缺乏来自伴侣的性接近(p结论：对于接受近距离放射治疗的妇科癌症患者，不仅要实施短期治疗，还要实施长期随访和支持性康复计划，这对于评估性症状和维持性健康至关重要。

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引用次数: 0

Strategies for improving healthcare provider communication with cancer patients about fertility preservation: a scoping review 改善医疗保健提供者与癌症患者关于保留生育能力的沟通策略：范围综述

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-11-03 DOI: 10.1016/j.ejon.2025.103034

Ying-Xiang Chen , You Zhou , Fu-Ying Ye, Xiao-Lan Zhang, Min Xu

Purpose

This study seeks to consolidate practices that improve healthcare practitioners' communication about fertility preservation with cancer patients. Through a scoping review, we seek to inform the development and implementation of effective strategies moving forward.

Methods

Nine databases were searched, including PubMed, CINAHL, Web of Science, ProQuest, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang Data, and VIP Database. The most recent search occurred on September 13, 2024. The inclusion criteria were established based on the PCC (Participants, Concept, Context) framework. The protocol for this scope review was unregistered.

Results

A total of 22 studies were included in this study, using 19 strategies to improve fertility preservation communication. These strategies were categorized into three main areas: educational tools, communication tools, and educational training. Educational tools comprised clinician instruction manuals, patient and family brochures, fertility risk assessment tools, fertility preservation option grids, educational videos, international guideline lists, checklists, and referral checklists. Communication tools included discussion scripts, stress eggs, automated reminder and recording systems, and the Frank narrative method. Educational training methods encompassed presentations, case studies, role play, video instruction, feedback and coaching, professional lectures, educational group meetings, and hands-on exercises.

Conclusion

Strategies for communicating fertility preservation enhanced healthcare practitioners' knowledge, communication abilities, satisfaction, and self-efficacy, while also improving the quality and frequency of communication. The results of this study hold considerable significance for healthcare practitioners in delivering oncologic reproductive support, enhancing patient quality of life and the quality of fertility preservation choices.

目的本研究旨在加强医疗保健从业者与癌症患者关于保留生育能力的沟通。通过范围审查，我们力求为今后有效战略的制定和实施提供信息。方法检索PubMed、CINAHL、Web of Science、ProQuest、Cochrane Library、Embase、中国知识基础设施、万方数据、VIP数据库等9个数据库。最近一次搜索发生在2024年9月13日。纳入标准是基于PCC（参与者，概念，背景）框架建立的。本次范围评审的方案未注册。结果本研究共纳入22项研究，采用19种策略改善生育保留沟通。这些策略被分为三个主要领域：教育工具、交流工具和教育培训。教育工具包括临床医生指导手册、患者和家庭手册、生育风险评估工具、生育保留选项网格、教育视频、国际指南清单、清单和转诊清单。沟通工具包括讨论脚本、压力蛋、自动提醒和记录系统，以及弗兰克叙事法。教育培训方法包括演讲、案例研究、角色扮演、视频指导、反馈和指导、专业讲座、教育小组会议和实践练习。结论生育保留沟通策略提高了保健医生的知识水平、沟通能力、满意度和自我效能感，同时提高了沟通质量和频率。本研究的结果对医疗保健从业者提供肿瘤生殖支持，提高患者的生活质量和生育保留选择的质量具有相当大的意义。

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引用次数: 0

Effectiveness and determinants of a digital health application-delivered intervention to promote rehabilitation exercises in non-adherent head and neck cancer patients: A clinical trial 促进非依从性头颈癌患者康复锻炼的数字健康应用交付干预的有效性和决定因素：一项临床试验

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1016/j.ejon.2025.103000

Tong Wu , Ting Han , Zehui Feng , Mingxuan Wang , Xiaoju Zhang , Dian Zhu , Yumei Dai , Xiaoyan Meng

Purpose

To evaluate the impact of a digital health application using the Health Belief Model and computer vision on head and neck cancer rehabilitation, and explore strong factors related to rehabilitation within the model.

Methods

A randomised controlled trial was conducted involving 108 patients with head and neck cancer (intervention group = 54, control group = 54). The intervention group received rehabilitation guided by the application, while the control group received usual care. Mandibular function, training adherence, health beliefs, pain perception, rehabilitation knowledge, fatigue, and quality of life between groups at T0 (baseline), T1 (1 month) and T2 (3 months) were assessed. Two-way ANOVA and multivariate regression with Bootstrap sampling were used to assess between group differences, intervention-time interactions, and mediation effects.

Results

The intervention significantly improved maximal mouth-opening (p < 0.001), mandibular function (p < 0.001), training frequency and duration (p < 0.001), perceived severity (p = 0.039), perceived benefits (p = 0.003), self-efficacy (p = 0.001), action cues (p < 0.001), and rehabilitation knowledge (p < 0.001). Additionally, the intervention group experienced a significant reduction in fatigue (p < 0.001). Mediation analysis showed that self-efficacy had the strongest positive mediating effect. Action cues and perceived benefits demonstrated both immediate (T0<T1, p < 0.001) and sustained (T0<T2, Cohen's d = −0.452) complementary effects. Although perceived severity enhanced rehabilitation knowledge (β = 0.378), it was also associated with increased fatigue (β = 0.389).

Conclusions

A Health Belief Model-based digital intervention significantly enhanced rehabilitation outcomes by improving self-efficacy, leveraging the complementary effects of perceived benefits and action cues, as well as the bidirectional effect of perceived severity.

Registration

Clinical trial registration:ChiCTR2400090305 (2024/09/27).

目的：评估基于健康信念模型和计算机视觉的数字健康应用程序对头颈癌康复的影响，并探索模型中与康复相关的强因素。方法：对108例头颈部肿瘤患者进行随机对照试验，干预组54例，对照组54例。干预组接受应用程序指导下的康复治疗，对照组接受常规护理。在T0（基线）、T1（1个月）和T2（3个月）时评估各组的下颌功能、训练依从性、健康信念、疼痛感知、康复知识、疲劳和生活质量。采用双因素方差分析和多因素回归与Bootstrap抽样来评估组间差异、干预时间相互作用和中介效应。结论：基于健康信念模型的数字化干预通过自我效能感的提高、感知利益与行动提示的互补效应以及感知严重程度的双向效应显著提高康复效果。注册：临床试验注册号：ChiCTR2400090305（2024/09/27）。

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引用次数: 0

Changes in hope, resilience and social support throughout chemotherapy and their association with health-related quality of life in cancer patients: A longitudinal study 化疗过程中希望、恢复力和社会支持的变化及其与癌症患者健康相关生活质量的关系：一项纵向研究

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.ejon.2025.102981

Sheung Yiu Chan , Xueyan Cheng , Pui Hing Chau , Hui-Mei Chen , Wing Lok Chan , Chia-Chin Lin , Denise Shuk Ting Cheung

Objective

To investigate the association between changes in hope, resilience, social support, and cancer-related symptoms, and the change in health-related quality of life among cancer patients during chemotherapy.

Methods

A prospective, longitudinal study was conducted among 126 cancer patients undergoing chemotherapy. Hope, resilience, and social support were measured using the Herth Hope Index, 14-item Resilience Scale, and Multidimensional Scale of Perceived Social Support, respectively. Quality of life was assessed using Functional Assessment of Cancer Therapy–General. All measures were administered before chemotherapy started and 1 month after chemotherapy completion. Linear mixed models were employed to analyze the changes in hope, resilience, social support, and quality of life. Multivariable linear regression analysis was employed to assess the association between the changes in the psychosocial variables and quality of life.

Results

Physical well-being and emotional well-being significantly improved 1 month after chemotherapy compared to baseline, while no significant change was observed in hope, resilience, or social support. Change in resilience was positively associated with emotional well-being (β = 0.09, 95 %CI: 0.003, 0.18), functional well-being (β = 0.16, 95 %CI: 0.09, 0.23), and overall quality of life (β = 0.33, 95 %CI: 0.09, 0.57). Change in social support showed a positive association with change in social well-being (β = 0.16, 95 %CI: 0.06, 0.25).

Conclusions

This longitudinal study demonstrates that improvements in resilience and social support are positively associated with enhanced quality of life during chemotherapy. Interventions enhancing resilience and social support may help to support cancer patients better during chemotherapy.

目的探讨癌症患者化疗期间希望、恢复力、社会支持、癌症相关症状变化与健康相关生活质量变化的关系。方法对126例接受化疗的癌症患者进行前瞻性、纵向研究。希望、弹性和社会支持分别采用赫斯希望指数、14项弹性量表和多维感知社会支持量表进行测量。使用癌症治疗功能评估（Functional Assessment of Cancer therapgeneral）评估生活质量。所有措施均在化疗开始前和化疗结束后1个月进行。采用线性混合模型分析希望、恢复力、社会支持和生活质量的变化。采用多变量线性回归分析来评估心理社会变量变化与生活质量之间的关系。结果化疗后1个月，患者的身体健康和情绪健康较基线有显著改善，而希望、恢复力和社会支持方面无显著变化。恢复力的变化与情绪幸福感（β = 0.09, 95% CI: 0.003, 0.18）、功能幸福感（β = 0.16, 95% CI: 0.09, 0.23）和整体生活质量（β = 0.33, 95% CI: 0.09, 0.57）呈正相关。社会支持的变化与社会幸福感的变化呈正相关（β = 0.16, 95% CI: 0.06, 0.25）。结论：这项纵向研究表明，化疗期间恢复力和社会支持的改善与生活质量的提高呈正相关。增强恢复力和社会支持的干预措施可能有助于在化疗期间更好地支持癌症患者。

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引用次数: 0

The effect of oral cryotherapy on taste alteration, appetite level, risk of malnutrition and quality of life in patients undergoing chemotherapy: A randomized controlled trial 口服冷冻治疗对化疗患者味觉改变、食欲水平、营养不良风险和生活质量的影响：一项随机对照试验。

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-09-28 DOI: 10.1016/j.ejon.2025.102991

Zeynep Pehlivan Köksal , Nesrin Nural , Oğuzhan Kesen

Purpose

This study aimed to evaluate the effect of oral cryotherapy on chemotherapy-induced taste alteration, appetite, nutritional risk, and quality of life in patients undergoing chemotherapy.

Methods

A randomized controlled trial was conducted with 65 patients receiving outpatient chemotherapy. Participants were assigned to an intervention group (oral cryotherapy plus standard care) or a control group (standard care only). Data were collected using validated tools, including the Chemotherapy-Induced Taste Alteration Scale (CITAS), the Simplified Nutritional Appetite Questionnaire (SNAQ), the Malnutrition Universal Screening Tool (MUST), and the EORTC QLQ-C30.

Results

Compared with the control group, patients receiving oral cryotherapy reported significantly lower levels of taste alteration and discomfort, alongside higher appetite and overall quality of life scores (p < 0.05). Nutritional markers such as albumin and total protein remained stable in the intervention group, while they declined in controls. These results suggest that oral cryotherapy may both alleviate taste-related symptoms and help maintain nutritional status during chemotherapy.

Conclusion

Oral cryotherapy was found to be an effective method for reducing the severity of chemotherapy-induced taste alterations and improving appetite and overall quality of life. Adherence to the protocol was high (%94), though the regimen is intensive and may challenge feasibility in routine practice. These findings highlight the potential of oral cryotherapy as a supportive care strategy, warranting confirmation in larger, multi-center studies.

目的：本研究旨在评估口服冷冻治疗对化疗患者味觉改变、食欲、营养风险和生活质量的影响。方法：对65例门诊化疗患者进行随机对照试验。参与者被分配到干预组（口服冷冻治疗加标准治疗）或对照组（仅标准治疗）。使用经过验证的工具收集数据，包括化疗诱导味觉改变量表（CITAS）、简化营养食欲问卷（SNAQ）、营养不良通用筛查工具（MUST）和EORTC QLQ-C30。结果：与对照组相比，接受口服冷冻治疗的患者报告的味觉改变和不适程度明显降低，同时食欲和整体生活质量评分更高(p)结论：口服冷冻治疗是减轻化疗引起的味觉改变严重程度、改善食欲和整体生活质量的有效方法。方案的依从性很高（%94），尽管方案是强化的，在常规实践中可能会挑战可行性。这些发现强调了口服冷冻疗法作为一种支持性护理策略的潜力，需要在更大规模的多中心研究中得到证实。

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引用次数: 0

Pathways between activity behaviors, emotional distress, and subjective cognitive impairment in middle-aged and older breast cancer patients receiving chemotherapy: a cross-sectional study 中老年乳腺癌化疗患者活动行为、情绪困扰和主观认知障碍之间的通路：一项横断面研究

IF 2.7 3区医学 Q1 NURSING

European Journal of Oncology Nursing

Pub Date : 2025-12-01 Epub Date: 2025-10-13 DOI: 10.1016/j.ejon.2025.103008

Ni Zhang , Baoyi Zhang , Lili Chen , Jingwen Yan , Yiheng Zhang , Ye Zhang , Jia Fang , Meifen Zhang

Purpose

To examine the pathways between activity behaviors, emotional distress, and subjective cognitive impairment (SCI) in middle-aged and older breast cancer patients (BCs) receiving chemotherapy.

Methods

In this cross-sectional study, patients were recruited via convenience sampling at a tertiary hospital in Guangzhou, China. SCI, depressive symptoms, anxiety symptoms, physical activity, and sedentary behavior were assessed using the Functional Assessment of Cancer Therapy-Cognitive Function, the 10-item version of the Center for Epidemiological Studies Depression Scale, the Brief Generalized Anxiety Disorder Scale, and the short form of the International Physical Activity Questionnaire. Structural equation modelling was conducted to test a hypothesized path model with depressive and anxiety symptoms as mediators.

Results

A total of 356 BCs (mean age = 54.07 years) were included. Depressive symptoms showed a strong association with higher SCI (β = 0.441, P < 0.001). Physical activity showed an indirect association with lower SCI through reduced depressive symptoms (β = −0.079, 95 %CI: −0.146 to −0.031). Physical activity was also negatively related to anxiety symptoms (β = −0.113, P < 0.05). After excluding anomalous cases, anxiety symptoms were additionally found to be significantly associated with SCI (β = 0.142, P < 0.001).

Conclusions

These findings highlight the potential relevance of depressive symptoms in the experience of SCI among middle-aged and older BCs receiving chemotherapy. The observed indirect association suggests that patients with low physical activity levels may warrant particular attention, as they may be at greater risk for depressive symptoms and cognitive complaints. Further interventional studies are needed to examine the potential benefit of physical activity for emotional well-being and SCI in this population.

目的：探讨中老年乳腺癌化疗患者活动行为、情绪困扰与主观认知功能障碍（SCI）之间的关系。方法：在本横断面研究中，通过方便抽样在中国广州的一家三级医院招募患者。脊髓损伤、抑郁症状、焦虑症状、身体活动和久坐行为的评估采用癌症治疗-认知功能功能评估、流行病学研究中心抑郁量表的10项版本、广泛性焦虑障碍简易量表和国际体育活动问卷的简短形式。采用结构方程模型检验以抑郁和焦虑症状为中介的假设路径模型。结果：共纳入356例BCs，平均年龄54.07岁。结论：这些发现强调了抑郁症状与中老年接受化疗的bc患者的脊髓损伤经历的潜在相关性。观察到的间接关联表明，体力活动水平低的患者可能需要特别注意，因为他们可能有更大的抑郁症状和认知疾病风险。需要进一步的介入研究来检验体育活动对这一人群的情绪健康和脊髓损伤的潜在益处。

{"title":"Pathways between activity behaviors, emotional distress, and subjective cognitive impairment in middle-aged and older breast cancer patients receiving chemotherapy: a cross-sectional study","authors":"Ni Zhang , Baoyi Zhang , Lili Chen , Jingwen Yan , Yiheng Zhang , Ye Zhang , Jia Fang , Meifen Zhang","doi":"10.1016/j.ejon.2025.103008","DOIUrl":"10.1016/j.ejon.2025.103008","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the pathways between activity behaviors, emotional distress, and subjective cognitive impairment (SCI) in middle-aged and older breast cancer patients (BCs) receiving chemotherapy.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, patients were recruited via convenience sampling at a tertiary hospital in Guangzhou, China. SCI, depressive symptoms, anxiety symptoms, physical activity, and sedentary behavior were assessed using the Functional Assessment of Cancer Therapy-Cognitive Function<em>,</em> the 10-item version of the Center for Epidemiological Studies Depression Scale, the Brief Generalized Anxiety Disorder Scale, and the short form of the International Physical Activity Questionnaire. Structural equation modelling was conducted to test a hypothesized path model with depressive and anxiety symptoms as mediators.</div></div><div><h3>Results</h3><div>A total of 356 BCs (mean age = 54.07 years) were included. Depressive symptoms showed a strong association with higher SCI (<em>β</em> = 0.441, <em>P</em> < 0.001). Physical activity showed an indirect association with lower SCI through reduced depressive symptoms (<em>β</em> = −0.079, 95 %CI: −0.146 to −0.031). Physical activity was also negatively related to anxiety symptoms (<em>β</em> = −0.113, <em>P</em> < 0.05). After excluding anomalous cases, anxiety symptoms were additionally found to be significantly associated with SCI (<em>β</em> = 0.142, <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential relevance of depressive symptoms in the experience of SCI among middle-aged and older BCs receiving chemotherapy. The observed indirect association suggests that patients with low physical activity levels may warrant particular attention, as they may be at greater risk for depressive symptoms and cognitive complaints. Further interventional studies are needed to examine the potential benefit of physical activity for emotional well-being and SCI in this population.</div></div>","PeriodicalId":51048,"journal":{"name":"European Journal of Oncology Nursing","volume":"79 ","pages":"Article 103008"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0