S. Seki, Akira Nishiura, Fumika Kishino, Yusuke Yokota, E. Isomura, Susumu Tanaka
Lateral cervical cysts are among the most frequent branchial anomalies of the neck, although they rarely become large.The present case involved a 32‐year‐old man with swelling of the right side of the neck. Pre‐operative CT findings showed a low CT value on the right side of the neck. Lateral cervical cyst removal was performed under general anesthesia, and the excision was 100 mm × 70 mm × 30 mm, which is the largest ever reported removal of a Bailey type I lateral cervical cyst.The patient had a good clinical course, with no post‐operative recurrence.
颈侧囊肿是最常见的颈部分支畸形之一，但很少发展为巨大囊肿。本病例中，一名 32 岁的男子颈部右侧肿胀。术前 CT 检查结果显示右侧颈部 CT 值较低。颈侧囊肿切除术是在全身麻醉下进行的，切除范围为 100 mm × 70 mm × 30 mm，这是迄今为止报道的最大的贝利 I 型颈侧囊肿切除术。
{"title":"A case of a giant Bailey type I lateral cervical cyst","authors":"S. Seki, Akira Nishiura, Fumika Kishino, Yusuke Yokota, E. Isomura, Susumu Tanaka","doi":"10.1002/osi2.1249","DOIUrl":"https://doi.org/10.1002/osi2.1249","url":null,"abstract":"Lateral cervical cysts are among the most frequent branchial anomalies of the neck, although they rarely become large.The present case involved a 32‐year‐old man with swelling of the right side of the neck. Pre‐operative CT findings showed a low CT value on the right side of the neck. Lateral cervical cyst removal was performed under general anesthesia, and the excision was 100 mm × 70 mm × 30 mm, which is the largest ever reported removal of a Bailey type I lateral cervical cyst.The patient had a good clinical course, with no post‐operative recurrence.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140997310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coaggregation and coadhesion are important mechanisms for oral bacteria to colonize the oral cavity and exert pathogenic effects. Fusobacterium nucleatum has been reported to coaggregate with various oral bacteria. Some of the coaggregation are inhibited by D‐galactose. D‐galactose, however, will be metabolized by oral bacteria when applied to the oral cavity, resulting in the acid generation that causes dental caries. In the present study, we developed a novel material, alkyl‐galactosides, that inhibits the coaggregation of F. nucleatum and is not metabolized by oral bacteria.Acid production from alkyl‐galactoside by Streptococcus mutans was determined by pH lowering during liquid culture. Antibacterial activity was measured using the minimum inhibitory concentration test, and coaggregation inhibitory effects were evaluated based on the relative coaggregation ratio between F. nucleatum and several oral bacteria using absorbance measurements.D‐galactose was rapidly metabolized by S. mutans, resulting in a decreased pH. Alkyl‐galactoside, however, was not metabolized by the bacterium at 1 mM. Minimum inhibitory concentration of alkyl‐galactoside against S. mutans is 1–4 mM. Alkyl‐galactoside inhibited coaggregation between F. nucleatum and several oral bacteria almost to the same extent as D‐galactose.Alkyl‐galactoside inhibits coaggregation between F. nucleatum and oral bacteria and is not assimilated by oral bacteria suggesting to be a potent novel material for prevention of dental plaque formation.
聚集和粘附是口腔细菌定植口腔并产生致病作用的重要机制。据报道，核酸镰刀菌可与多种口腔细菌聚合。其中一些共聚受到 D-半乳糖的抑制。然而，D-半乳糖在应用于口腔时会被口腔细菌代谢，从而产生导致龋齿的酸性物质。在本研究中，我们开发了一种新型材料--烷基-半乳糖苷，它能抑制核酸痢疾杆菌的聚集，并且不会被口腔细菌代谢。使用最小抑菌浓度试验测定抗菌活性，并使用吸光度测量法根据核酸噬菌体和几种口腔细菌之间的相对聚集比评估聚集抑制作用。然而，烷基半乳糖苷在 1 mM 的浓度下不会被该细菌代谢。烷基半乳糖苷对突变菌的最小抑制浓度为 1-4 mM。烷基半乳糖苷对核酸垢桿菌和几种口腔细菌之间的聚集有抑制作用，其抑制程度几乎与 D-半乳糖相同。烷基半乳糖苷能抑制核酸垢桿菌和口腔细菌之间的聚集，而且不会被口腔细菌同化，这表明它是一种有效的新型材料，可用于预防牙菌斑的形成。
{"title":"Inhibitory effects of alkyl‐galactosides on the coaggregation of Fusobacterium nucleatum and oral bacteria","authors":"Teppei Tajikara, Morihide Itano, Yoshitaka Yano, Natsuko Toshida, K. Ueno, Yoichiro Miyake","doi":"10.1002/osi2.1245","DOIUrl":"https://doi.org/10.1002/osi2.1245","url":null,"abstract":"Coaggregation and coadhesion are important mechanisms for oral bacteria to colonize the oral cavity and exert pathogenic effects. Fusobacterium nucleatum has been reported to coaggregate with various oral bacteria. Some of the coaggregation are inhibited by D‐galactose. D‐galactose, however, will be metabolized by oral bacteria when applied to the oral cavity, resulting in the acid generation that causes dental caries. In the present study, we developed a novel material, alkyl‐galactosides, that inhibits the coaggregation of F. nucleatum and is not metabolized by oral bacteria.Acid production from alkyl‐galactoside by Streptococcus mutans was determined by pH lowering during liquid culture. Antibacterial activity was measured using the minimum inhibitory concentration test, and coaggregation inhibitory effects were evaluated based on the relative coaggregation ratio between F. nucleatum and several oral bacteria using absorbance measurements.D‐galactose was rapidly metabolized by S. mutans, resulting in a decreased pH. Alkyl‐galactoside, however, was not metabolized by the bacterium at 1 mM. Minimum inhibitory concentration of alkyl‐galactoside against S. mutans is 1–4 mM. Alkyl‐galactoside inhibited coaggregation between F. nucleatum and several oral bacteria almost to the same extent as D‐galactose.Alkyl‐galactoside inhibits coaggregation between F. nucleatum and oral bacteria and is not assimilated by oral bacteria suggesting to be a potent novel material for prevention of dental plaque formation.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"317 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The crista galli (CG), located in the anterior cranial fossa and associated with the cranial structures here, is a bony prominence on the ethmoid bone. In this study, we aimed to examine the anatomical variations and pneumatization status of the CG in individuals with cleft lip and palate (CLP) and to compare them with those of individuals without CLP.Data from 16‐ to 25‐year‐old individuals with non‐syndromic cleft lip and palate and control individuals without any syndrome or disease who underwent cone beam computed tomography were used. Measurement of the CG height (superoinferior, on the coronal section), width (laterolateral, on the axial section), and length (anteroposterior, on the axial section) dimensions. In addition, a categorical evaluation of CG morphology, CG pneumatization, olfactory fossa depth, and position of the CG in the ethmoid area (Keros classification) was performed.Although the superoinferior diameter and laterolateral diameter values of the CG did not differ between the groups, the anteroposterior diameter values were found to be significantly (p = 0.047) lower in individuals with CLP (11.95 ± 2.57 mm) compared with control (13.23 ± 2.05 mm). There was no difference in the morphology or pneumatization status of the CG between the groups.Except for the anteroposterior length, there was no difference in CG morphometric measurements between individuals with CLP and control. The anteroposterior length was shorter in individuals with CLP.
{"title":"Assessment of crista galli morphology and morphometry in individuals with cleft lip and palate: A three‐dimensional analysis","authors":"T. Ozturk, Sertan Soylu, Aykagan Cukurluoglu","doi":"10.1002/osi2.1238","DOIUrl":"https://doi.org/10.1002/osi2.1238","url":null,"abstract":"The crista galli (CG), located in the anterior cranial fossa and associated with the cranial structures here, is a bony prominence on the ethmoid bone. In this study, we aimed to examine the anatomical variations and pneumatization status of the CG in individuals with cleft lip and palate (CLP) and to compare them with those of individuals without CLP.Data from 16‐ to 25‐year‐old individuals with non‐syndromic cleft lip and palate and control individuals without any syndrome or disease who underwent cone beam computed tomography were used. Measurement of the CG height (superoinferior, on the coronal section), width (laterolateral, on the axial section), and length (anteroposterior, on the axial section) dimensions. In addition, a categorical evaluation of CG morphology, CG pneumatization, olfactory fossa depth, and position of the CG in the ethmoid area (Keros classification) was performed.Although the superoinferior diameter and laterolateral diameter values of the CG did not differ between the groups, the anteroposterior diameter values were found to be significantly (p = 0.047) lower in individuals with CLP (11.95 ± 2.57 mm) compared with control (13.23 ± 2.05 mm). There was no difference in the morphology or pneumatization status of the CG between the groups.Except for the anteroposterior length, there was no difference in CG morphometric measurements between individuals with CLP and control. The anteroposterior length was shorter in individuals with CLP.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":" 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akio Himejima, Shuji Ueno, Koji Yamada, Masayuki Kamitani, Chikako Hosoyama, T. Iseki
This report describes the case of a patient with jaw deformity, osteogenesis imperfecta (OI), and low von Willebrand factor (low VWF).A 30‐year‐old woman with OI was referred for the treatment of prognathism of the lower jaw. Laboratory data showed that partial thromboplastin time was slightly increased, so additional testing was performed and revealed low VWF. The patient was then administered 1‐desamino‐8‐D‐arginine vasopressin before orthognathic surgery and experienced no hemorrhagic episodes perioperatively.As both OI patients and low VWF patients are at greater risk of hemorrhage, surgery in such cases should be performed with due consideration of and preparation for bleeding.
{"title":"Orthognathic surgery in a patient with osteogenesis imperfecta and low von Willebrand factor","authors":"Akio Himejima, Shuji Ueno, Koji Yamada, Masayuki Kamitani, Chikako Hosoyama, T. Iseki","doi":"10.1002/osi2.1235","DOIUrl":"https://doi.org/10.1002/osi2.1235","url":null,"abstract":"This report describes the case of a patient with jaw deformity, osteogenesis imperfecta (OI), and low von Willebrand factor (low VWF).A 30‐year‐old woman with OI was referred for the treatment of prognathism of the lower jaw. Laboratory data showed that partial thromboplastin time was slightly increased, so additional testing was performed and revealed low VWF. The patient was then administered 1‐desamino‐8‐D‐arginine vasopressin before orthognathic surgery and experienced no hemorrhagic episodes perioperatively.As both OI patients and low VWF patients are at greater risk of hemorrhage, surgery in such cases should be performed with due consideration of and preparation for bleeding.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"2018 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kohei Ishikawa, Y. Matsuoka, Kosuke Shinohara, Junki Inoue, H. Yano, Takafumi Eto, Tatsuro Yamamoto, K. Yamana, Shunsuke Gohara, H. Takeshita, Masatoshi Hirayama, K. Kawahara, A. Hirosue, Y. Fukugawa, R. Yoshida, Yoshihiro Komohara, Hideki Nakayama
Radiotherapy, the mainstay treatment for patients with advanced oral squamous cell carcinoma (OSCC), has low clinical efficacy, resulting in poor prognosis. Radiation induces ferroptosis, a form of cell death driven by iron‐dependent lipid peroxidation. Since the xCT/glutathione peroxidase 4 (GPX4) axis is predominantly involved in the ferroptosis defense system, targeting this axis may potentiate cancer cell vulnerability to ferroptosis.We examined the expression of xCT and GPX4 in the tumor cells of biopsy specimens using immunohistochemistry and evaluated the radiation‐mediated antitumor effects of the ferroptosis inducers, erastin and RSL3, that act by inhibiting xCT and GPX4, respectively.Univariate analysis revealed that high immunohistochemical expression of xCT was correlated with shorter survival, and high GPX4 expression was an independent poor prognostic factor, indicating that the xCT/GPX4 axis influences the clinical outcome of OSCC. Analyses using two types of OSCC cell lines revealed that the clonogenic survival of irradiated cells was increased by the ferroptosis inhibitor ferrostatin‐1 and decreased by erastin and RSL3. The enhanced antitumor effects of erastin and RSL3 were accompanied by increased lipid peroxidation, which was suppressed by the iron chelator deferoxamine. Erastin and RSL3 enhance the effects of radiation on OSCC cells in a mouse xenograft model; these effects were associated with increased expression of the lipid peroxidation marker 4‐hydroxynonenal in tumor cells.xCT/GPX4 axis is involved in the tumor resistance against radiation through the inhibition of ferroptosis in OSCC. Furthermore, radiotherapy combined with ferroptosis induction by targeting the xCT/GPX4 axis may improve patient prognosis in advanced OSCC.
{"title":"Involvement of ferroptosis‐defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma","authors":"Kohei Ishikawa, Y. Matsuoka, Kosuke Shinohara, Junki Inoue, H. Yano, Takafumi Eto, Tatsuro Yamamoto, K. Yamana, Shunsuke Gohara, H. Takeshita, Masatoshi Hirayama, K. Kawahara, A. Hirosue, Y. Fukugawa, R. Yoshida, Yoshihiro Komohara, Hideki Nakayama","doi":"10.1002/osi2.1227","DOIUrl":"https://doi.org/10.1002/osi2.1227","url":null,"abstract":"Radiotherapy, the mainstay treatment for patients with advanced oral squamous cell carcinoma (OSCC), has low clinical efficacy, resulting in poor prognosis. Radiation induces ferroptosis, a form of cell death driven by iron‐dependent lipid peroxidation. Since the xCT/glutathione peroxidase 4 (GPX4) axis is predominantly involved in the ferroptosis defense system, targeting this axis may potentiate cancer cell vulnerability to ferroptosis.We examined the expression of xCT and GPX4 in the tumor cells of biopsy specimens using immunohistochemistry and evaluated the radiation‐mediated antitumor effects of the ferroptosis inducers, erastin and RSL3, that act by inhibiting xCT and GPX4, respectively.Univariate analysis revealed that high immunohistochemical expression of xCT was correlated with shorter survival, and high GPX4 expression was an independent poor prognostic factor, indicating that the xCT/GPX4 axis influences the clinical outcome of OSCC. Analyses using two types of OSCC cell lines revealed that the clonogenic survival of irradiated cells was increased by the ferroptosis inhibitor ferrostatin‐1 and decreased by erastin and RSL3. The enhanced antitumor effects of erastin and RSL3 were accompanied by increased lipid peroxidation, which was suppressed by the iron chelator deferoxamine. Erastin and RSL3 enhance the effects of radiation on OSCC cells in a mouse xenograft model; these effects were associated with increased expression of the lipid peroxidation marker 4‐hydroxynonenal in tumor cells.xCT/GPX4 axis is involved in the tumor resistance against radiation through the inhibition of ferroptosis in OSCC. Furthermore, radiotherapy combined with ferroptosis induction by targeting the xCT/GPX4 axis may improve patient prognosis in advanced OSCC.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazumichi Sato, Kinue Kurihara, Aya Tanaka, Masayasu Yoshida, Kazumi Sekiya, Ken Ishizaki
Cemento‐osseous dysplasia (COD) is a benign, non‐neoplastic, fibro‐osseous lesion that is often asymptomatic and discovered incidentally on dental radiographs. Radiological examination, rather than biopsy, is recommended for diagnosis because of the risk of infection. The dentist working at a hospital sometimes requests a family dentist to follow up on the progress of COD discovered accidentally during panoramic radiography at a hospital. However, there are few reports on the prevalence of COD on panoramic radiographs obtained at the oral surgery department of a hospital; therefore, we investigated this in this study.We examined the prevalence of COD with calcification (classification, presence of infection, and complications with simple bone cysts) in 1194 patients for whom panoramic radiographs were obtained.Twelve patients (1.0%) had findings of COD with calcification: four cases of periapical COD (three females and one male), five cases of focal COD (four females and one male), and three cases of florid COD (three females and zero males). Infection was seen in one case of Florid COD and one case of Focal COD. A simple bone cyst was observed in one patient with Florid COD.COD with calcification was observed in a certain percentage of patients, and many were asymptomatic. Dental healthcare workers need to understand that COD carries a risk of infection and that there are diseases that need to be differentiated. Patients should also be advised about the need for long‐term follow‐up.
牙骨质发育不良（COD）是一种良性、非肿瘤性的纤维骨病变，通常无症状，在牙科 X 光片上偶然发现。由于存在感染风险，建议采用放射学检查而非活检进行诊断。在医院工作的牙医有时会要求家庭牙医跟进在医院进行全景放射检查时意外发现的 COD 的进展情况。我们对 1194 名接受过全景 X 光检查的患者中伴有钙化的 COD 的患病率（分类、是否存在感染以及单纯骨囊肿的并发症）进行了调查。12名患者（1.0%）发现了伴有钙化的COD：4例根尖周COD（3名女性和1名男性）、5例局灶性COD（4名女性和1名男性）和3例花斑状COD（3名女性和0名男性）。在一例花斑型 COD 和一例病灶型 COD 中发现了感染。在一名Florid COD患者中观察到了单纯骨囊肿。在一定比例的患者中观察到了伴有钙化的COD，其中许多患者没有症状。牙科医护人员需要明白，COD 有感染的风险，而且有些疾病需要加以区分。还应告知患者需要进行长期随访。
{"title":"Prevalence of panoramic radiographs findings of cementum‐osseous dysplasia with calcification in the department of oral surgery at hospital: A retrospective study","authors":"Kazumichi Sato, Kinue Kurihara, Aya Tanaka, Masayasu Yoshida, Kazumi Sekiya, Ken Ishizaki","doi":"10.1002/osi2.1234","DOIUrl":"https://doi.org/10.1002/osi2.1234","url":null,"abstract":"Cemento‐osseous dysplasia (COD) is a benign, non‐neoplastic, fibro‐osseous lesion that is often asymptomatic and discovered incidentally on dental radiographs. Radiological examination, rather than biopsy, is recommended for diagnosis because of the risk of infection. The dentist working at a hospital sometimes requests a family dentist to follow up on the progress of COD discovered accidentally during panoramic radiography at a hospital. However, there are few reports on the prevalence of COD on panoramic radiographs obtained at the oral surgery department of a hospital; therefore, we investigated this in this study.We examined the prevalence of COD with calcification (classification, presence of infection, and complications with simple bone cysts) in 1194 patients for whom panoramic radiographs were obtained.Twelve patients (1.0%) had findings of COD with calcification: four cases of periapical COD (three females and one male), five cases of focal COD (four females and one male), and three cases of florid COD (three females and zero males). Infection was seen in one case of Florid COD and one case of Focal COD. A simple bone cyst was observed in one patient with Florid COD.COD with calcification was observed in a certain percentage of patients, and many were asymptomatic. Dental healthcare workers need to understand that COD carries a risk of infection and that there are diseases that need to be differentiated. Patients should also be advised about the need for long‐term follow‐up.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Van der Woude syndrome is characterized by the concurrence of cleft lip and palate with lower lip fistulas. During fistula resection, care must be taken to maintain the function of the orbicularis oris and restore the normal shape of the lips. Several reports have documented various resection methods; however, the most appropriate surgical resection is controversial. In this report, lower lip fistulas were resected using an inverted‐T surgical design.Of the six patients with Van der Woude syndrome who underwent resection of the lower lip fistula in our department between January 2007 and December 2015, three patients who underwent inverted‐T lip reduction were included. The postoperative position‐dependent morphology of the fistulas was examined.Five years postoperatively, no complications such as postoperative infections, mucous retention cyst formation, a dysmorphic appearance of the lip, or fistula recurrence were observed. Moreover, a stable wound morphology was evident.The inverted‐T lip reduction seems to be promising technique for the excision of lower lip fistulas in patients with Van der Woude syndrome, yielding good results.
范德乌德综合征的特点是唇腭裂和下唇瘘管并存。在切除瘘管时，必须注意保持口轮匝肌的功能，并恢复嘴唇的正常形状。多份报告记录了各种切除方法，但最合适的手术切除方法仍存在争议。在本报告中，我们采用倒 T 型手术设计切除了下唇瘘。2007 年 1 月至 2015 年 12 月期间，在我科接受下唇瘘切除术的 6 例范德武德综合征患者中，有 3 例患者接受了倒 T 型缩唇术。术后五年，未发现术后感染、粘液潴留囊肿形成、唇部外观畸形或瘘管复发等并发症。此外，伤口形态明显稳定。倒 T 形缩唇术似乎是范德乌德综合征患者切除下唇瘘管的一种很有前途的技术，能取得良好的效果。
{"title":"Treating lower lip fistulas in Van der Woude syndrome using inverted‐T lip reduction: An experience","authors":"Rika Narita, Hideto Saijo, M. Kashiwagi, Sachi Oshima, Asako Taniguchi, Kazuto Hoshi","doi":"10.1002/osi2.1232","DOIUrl":"https://doi.org/10.1002/osi2.1232","url":null,"abstract":"Van der Woude syndrome is characterized by the concurrence of cleft lip and palate with lower lip fistulas. During fistula resection, care must be taken to maintain the function of the orbicularis oris and restore the normal shape of the lips. Several reports have documented various resection methods; however, the most appropriate surgical resection is controversial. In this report, lower lip fistulas were resected using an inverted‐T surgical design.Of the six patients with Van der Woude syndrome who underwent resection of the lower lip fistula in our department between January 2007 and December 2015, three patients who underwent inverted‐T lip reduction were included. The postoperative position‐dependent morphology of the fistulas was examined.Five years postoperatively, no complications such as postoperative infections, mucous retention cyst formation, a dysmorphic appearance of the lip, or fistula recurrence were observed. Moreover, a stable wound morphology was evident.The inverted‐T lip reduction seems to be promising technique for the excision of lower lip fistulas in patients with Van der Woude syndrome, yielding good results.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"196 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaori Ebata, Yoshitaka Kise, Takahiko Morotomi, E. Ariji
To validate the performance of a deep learning system with detection and classification functions for a mix of radiolucent and radiopaque lesions in the anterior maxilla on panoramic radiographs.Patients with radiolucent or radiopaque lesions in the anterior maxilla on panoramic radiographs were selected retroactively from May 2022 until Feb 2002 to obtain 100 preoperative radiographs each for nasopalatine duct cysts (NDCs), radicular cysts (RCs), and impacted supernumerary teeth (ISTs). An additional 100 patients with no lesions in the anterior maxilla were selected. Two deep learning systems (Systems 1 and 2) were created and tested. For System 1, the models were created and tested using datasets of radiolucent lesions (NDCs and RCs) and No lesions. For developing System 2, the data of radiopaque lesions (ISTs) were added to those used in System 1. The neural network used was You Only Look Once ver. 7 (YOLOv7). The recall, precision, F1 score, and accuracy calculated from the confusion matrix were used to evaluate diagnostic performance.The performance of System 2, which included the IST data, was worse than that of System 1. Even when NDCs and RCs were addressed as a joint category of radiolucent lesions, the addition of IST data resulted in a worse performance than that of System 1.Our results indicate that combined use of radiopaque lesions (ISTs) with radiolucent lesions (NDCs and RCs) reduces the deep learning performance for radiolucent lesions with the volume of data used in the present study.
验证具有检测和分类功能的深度学习系统对全景X光片上上颌骨前部放射性和不透明混合病变的性能。从 2022 年 5 月到 2002 年 2 月，我们追溯性地选取了全景X光片上上颌骨前部有放射状或不透明病变的患者，为鼻腭管囊肿 (NDC)、放射状囊肿 (RC) 和撞击性上生牙 (IST) 各采集了 100 张术前 X 光片。另外还选择了 100 名上颌骨前部无病变的患者。创建并测试了两个深度学习系统（系统 1 和系统 2）。对于系统 1，使用放射性病变（NDC 和 RC）和无病变的数据集创建和测试了模型。在开发系统 2 时，在系统 1 的基础上增加了不透射线病变（IST）的数据。使用的神经网络是 You Only Look Once ver.7（YOLOv7）。根据混淆矩阵计算出的召回率、精确度、F1 分数和准确率被用来评估诊断性能。我们的结果表明，结合使用不透射线病变（IST）和透射线病变（NDC 和 RC）会降低本研究中使用的数据量对透射线病变的深度学习性能。
{"title":"Performance of a deep learning system for simultaneously diagnosing radiolucent and radiopaque lesions in the anterior maxilla on panoramic radiographs","authors":"Kaori Ebata, Yoshitaka Kise, Takahiko Morotomi, E. Ariji","doi":"10.1002/osi2.1233","DOIUrl":"https://doi.org/10.1002/osi2.1233","url":null,"abstract":"To validate the performance of a deep learning system with detection and classification functions for a mix of radiolucent and radiopaque lesions in the anterior maxilla on panoramic radiographs.Patients with radiolucent or radiopaque lesions in the anterior maxilla on panoramic radiographs were selected retroactively from May 2022 until Feb 2002 to obtain 100 preoperative radiographs each for nasopalatine duct cysts (NDCs), radicular cysts (RCs), and impacted supernumerary teeth (ISTs). An additional 100 patients with no lesions in the anterior maxilla were selected. Two deep learning systems (Systems 1 and 2) were created and tested. For System 1, the models were created and tested using datasets of radiolucent lesions (NDCs and RCs) and No lesions. For developing System 2, the data of radiopaque lesions (ISTs) were added to those used in System 1. The neural network used was You Only Look Once ver. 7 (YOLOv7). The recall, precision, F1 score, and accuracy calculated from the confusion matrix were used to evaluate diagnostic performance.The performance of System 2, which included the IST data, was worse than that of System 1. Even when NDCs and RCs were addressed as a joint category of radiolucent lesions, the addition of IST data resulted in a worse performance than that of System 1.Our results indicate that combined use of radiopaque lesions (ISTs) with radiolucent lesions (NDCs and RCs) reduces the deep learning performance for radiolucent lesions with the volume of data used in the present study.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140450424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Shimada, Hideki Miyazaki, Akira Hangaishi, Yutaka Maruoka
Multiple myeloma (MM) is a hematopoietic malignancy characterized by monoclonal plasma cell proliferation. Mandibular involvement in patients with MM is rare, and its clinical and radiological characteristics remain unclear.A 78‐year‐old man presented with MM in the mandible, mimicking a radicular cyst. Chemotherapy yielded a poor prognosis, and the patient died 1.5 years post‐diagnosis. Literature suggests that jawbone involvement of MM is a poor prognostic factor.This report highlights the features of MM in the jawbone, and its variable manifestation, which may include non‐neoplastic findings, thus emphasizing the importance of a definitive biopsy‐based diagnosis.
{"title":"Multiple myeloma in the mandible mimicking a radicular cyst: A case report and literature review","authors":"Y. Shimada, Hideki Miyazaki, Akira Hangaishi, Yutaka Maruoka","doi":"10.1002/osi2.1229","DOIUrl":"https://doi.org/10.1002/osi2.1229","url":null,"abstract":"Multiple myeloma (MM) is a hematopoietic malignancy characterized by monoclonal plasma cell proliferation. Mandibular involvement in patients with MM is rare, and its clinical and radiological characteristics remain unclear.A 78‐year‐old man presented with MM in the mandible, mimicking a radicular cyst. Chemotherapy yielded a poor prognosis, and the patient died 1.5 years post‐diagnosis. Literature suggests that jawbone involvement of MM is a poor prognostic factor.This report highlights the features of MM in the jawbone, and its variable manifestation, which may include non‐neoplastic findings, thus emphasizing the importance of a definitive biopsy‐based diagnosis.","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"58 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryutaro Ono, Mariko Kano, Yumi Fujikawa, Toshiro Yamamoto, N. Kanamura
{"title":"Elevated alveolar bone mineral density in female patients undergoing bisphosphonate therapy: A pilot cross‐sectional study using intraoral radiographs","authors":"Ryutaro Ono, Mariko Kano, Yumi Fujikawa, Toshiro Yamamoto, N. Kanamura","doi":"10.1002/osi2.1231","DOIUrl":"https://doi.org/10.1002/osi2.1231","url":null,"abstract":"","PeriodicalId":510615,"journal":{"name":"Oral Science International","volume":"52 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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