Maturitas最新文献

{"title":"The burden of sleep disturbances and vasomotor symptoms on work productivity, activity impairment and healthcare resource use in perimenopausal and postmenopausal women","authors":"Paula Briggs ,&nbsp;Carina Dinkel-Keuthage ,&nbsp;Joehl Nguyen ,&nbsp;Nils Schoof ,&nbsp;Carsten Moeller ,&nbsp;Kristina Rosa Bolling ,&nbsp;Kushal Modi ,&nbsp;Sheila Drakeley ,&nbsp;Lin Yang ,&nbsp;Shaloo Gupta ,&nbsp;Claudio N. Soares","doi":"10.1016/j.maturitas.2025.108758","DOIUrl":"10.1016/j.maturitas.2025.108758","url":null,"abstract":"<div><h3>Objective</h3><div>To explore relationships between sleep disturbances and vasomotor symptoms (VMS) with work productivity/activity impairment (WPAI) and healthcare visits among peri- and postmenopausal women.</div></div><div><h3>Study design</h3><div>We analyzed data from peri- and postmenopausal women aged 40–65 years who participated in the National Health and Wellness 2019/2021 survey (in the US; <em>N</em> = 27,621) and 2017/2020 survey (in France, Germany, Italy, Spain, and the UK; <em>N</em> = 20,220). We used generalized linear regression to calculate adjusted estimated marginal means (EMMs) to assess differences between four subgroups based on self-reported sleep disturbances and VMS.</div></div><div><h3>Main outcome measures</h3><div>Scores on the WPAI questionnaire (higher scores indicating worse outcomes); number of healthcare visits in the previous 6 months.</div></div><div><h3>Results</h3><div>Among postmenopausal women, those with symptoms had worse WPAI outcomes than those with neither type of symptom. The highest scores (worst outcomes) were seen for women with both symptoms: the EMMs for this group in the US survey, vs. those with neither symptom, were 11.9 % vs. 9.3 % for presenteeism, 12.8 % vs. 10.2 % for work productivity impairment, and 20.3 % vs. 16.2 % for activity impairment. Corresponding estimates for Europe were 17.4 % vs. 12.9 % for presenteeism, 18.8 % vs. 14.4 % for work productivity impairment, and 28.1 % vs. 20.9 % for activity impairment. Worse WPAI outcomes were not clearly observed in perimenopausal women with symptoms vs. those with no symptoms. However, both peri- and postmenopausal women with symptoms had more previous healthcare visits than those with neither symptom, especially those with sleep disturbances irrespective of co-occurring VMS.</div></div><div><h3>Conclusions</h3><div>Sleep disturbances and VMS were associated with worse WPAI scores and more healthcare visits in postmenopausal women, indicating a need for effective management of these symptoms among this population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108758"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the association between dietary metals and prostate health: Identifying benign prostatic hyperplasia using a SHAP-based interpretable machine learning model in US adults","authors":"Yan Wang ,&nbsp;Jiaming Chen ,&nbsp;Wangqiang Chen ,&nbsp;Xuejuan Jiang ,&nbsp;Caifei Ding ,&nbsp;Jingyu Zhu","doi":"10.1016/j.maturitas.2025.108776","DOIUrl":"10.1016/j.maturitas.2025.108776","url":null,"abstract":"<div><h3>Background</h3><div>Benign prostatic hyperplasia affects roughly 50 % of men aged 51–60 and 70 % of those aged 61–70. While heavy metals have been linked to prostate cancer and inflammation, little is known about how the dietary intake of trace metals influences BPH risk. This study aimed to establish an interpretable, machine-learning–based framework using U.S. NHANES data to identify key dietary metals associated with BPH risk.</div></div><div><h3>Methods</h3><div>We analyzed adult male participants from NHANES cycles 2005–2008, extracting daily intake estimates for six trace metals. This study compared six algorithms to elucidate the relationship between dietary metal intake and BPH risk, assessing their performance in associating BPH risk across seven evaluation metrics to identify the optimal model and enhance interpretability through analysis with SHapley Additive exPlanations (SHAP). Subgroup analyses explored nonlinear intake–risk relationships.</div></div><div><h3>Results</h3><div>LightGBM demonstrated superior performance (AUC = 0.668). SHAP ranking identified zinc, iron, and selenium as the top protective nutrients. The most pronounced protective effect against BPH was observed within the moderate zinc and selenium intake strata. Iron demonstrated a consistent protective association, with risk reduction observed across its intake range. Copper intake demonstrated a shift from risk reduction for BPH at low to moderate levels to an increased risk at high intake levels.</div></div><div><h3>Conclusions</h3><div>These findings suggest that calibrated intake of these key micronutrients may attenuate BPH susceptibility, providing a data-driven foundation for targeted nutritional interventions and public-health strategies.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108776"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of scores on the life's essential 8 scale with progression to type 2 diabetes, heart failure, and death: a multistate Markov model analysis","authors":"Xinke Wang ,&nbsp;Ning Ning ,&nbsp;Yumeng Li ,&nbsp;Rong Huang ,&nbsp;Yang Liu ,&nbsp;Yating Miao ,&nbsp;Wenwen Zhang ,&nbsp;Shuohua Chen ,&nbsp;Jingli Gao ,&nbsp;Shouling Wu ,&nbsp;Yanan Ma","doi":"10.1016/j.maturitas.2025.108760","DOIUrl":"10.1016/j.maturitas.2025.108760","url":null,"abstract":"<div><h3>Background</h3><div>Score on the Life's Essential 8 scale, which assesses cardiovascular health, is associated with the risks of cardiometabolic diseases. However, existing studies often overlook the dynamic nature of disease progression and the interactions among the components of the Life's Essential 8 scale.</div></div><div><h3>Objective</h3><div>This study investigated the association of Life's Essential 8 scores with transitions among type 2 diabetes, heart failure, and all-cause mortality using a multistate Markov model.</div></div><div><h3>Methods</h3><div>A prospective analysis was conducted on 70,369 participants in the Kailuan Study who were free of type 2 diabetes and heart failure at baseline. Life's Essential 8 scores (0−100) were derived from health factors (body mass index, blood pressure, blood lipids) and health behaviors (diet, physical activity, nicotine exposure, sleep). Multistate models evaluated transitions between baseline, type 2 diabetes, heart failure, and death, adjusting for sociodemographic and lifestyle covariates.</div></div><div><h3>Results</h3><div>Higher Life's Essential 8 scores were associated with reduced risks (hazard ratios, 95 % confidence intervals) of transitioning from baseline to type 2 diabetes (0.26, 0.24–0.28), heart failure (0.37, 0.29–0.47), and death (0.61, 0.54–0.69); and of transitioning from type 2 diabetes to heart failure (0.52, 0.33–0.81) and to death (0.68, 0.50–0.93). Health factors (body mass index, blood pressure) showed the strongest inverse associations with type 2 diabetes and heart failure progression, while health behaviors (nicotine exposure, sleep health) mitigated heart failure and mortality risks. Subgroup analyses revealed that age, sex, educational level, occupation, and alcohol consumption do not modify the effects of Life's Essential 8 scores.</div></div><div><h3>Conclusions</h3><div>Higher Life's Essential 8 scores were inversely associated with the dynamic risks of developing type 2 diabetes, heart failure, and death. Health factors predominantly influenced early transitions, while health behaviors had a greater impact on later stages of the process. Integrating administration of the Life's Essential 8 scale into clinical practice may benefit disease prevention, particularly in high-risk populations.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108760"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145411008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between chronic pain and the clustering of menopausal symptoms: Evidence from a British birth cohort study","authors":"Catherine Borra ,&nbsp;Rebecca Hardy","doi":"10.1016/j.maturitas.2025.108756","DOIUrl":"10.1016/j.maturitas.2025.108756","url":null,"abstract":"<div><h3>Background</h3><div>Cross-sectional studies have demonstrated an association between menopausal symptoms and chronic pain, but the direction of the association remains unknown. We assessed whether chronic pain is associated with subsequent clusters of menopausal symptoms.</div></div><div><h3>Methods</h3><div>We used data from the National Child Development Study, a birth cohort of people born in 1958 in England, Scotland and Wales, which has included a biomedical sweep at age 44 when chronic pain was assessed and a 20-item menopause symptom questionnaire at age 50. Chronic pain was defined as lasting longer than 3 months, and chronic widespread pain was defined as chronic contralateral upper and lower quadrant pain and spinal pain. Latent class analysis was used to define menopause symptom classes (<em>n</em> = 4897) and structural equation models (<em>n</em> = 3308) to relate chronic pain and chronic widespread pain to these classes, adjusting for confounding variables.</div></div><div><h3>Results</h3><div>We found four latent classes of menopause symptom experience at 50 years. These were a low symptom burden class, one defined by vasomotor symptoms, one by psychological symptoms and one with high symptom burden. Chronic pain and chronic widespread pain at 44 years were related to greater odds of being in the higher symptom burden classes compared with the low burden group. For example, the odds ratio (95 % confidence interval) for the high symptom burden class was 2.90 (2.21, 3.81) for chronic pain and 3.50 (2.23, 5.49) for chronic widespread pain, and for the vasomotor symptom class 1.50 (1.16, 1.94) for chronic pain and 1.93 (1.19, 3.13) for chronic widespread pain.</div></div><div><h3>Conclusion</h3><div>Women with chronic pain and chronic widespread pain earlier in life may experience greater burden of menopausal symptoms and this should be considered in their clinical management.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108756"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intra-articular hyaluronic acid injections on pain and function in patients with knee osteoarthritis: An umbrella review of systematic reviews and meta-analyses of randomized placebo-controlled trials","authors":"Olivier Bruyère ,&nbsp;Majed Alokail ,&nbsp;Nasser Al-Daghri ,&nbsp;Jean-Yves Reginster ,&nbsp;Shaun Sabico","doi":"10.1016/j.maturitas.2025.108779","DOIUrl":"10.1016/j.maturitas.2025.108779","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Knee osteoarthritis is a prevalent and disabling condition characterized by pain and functional impairment. Intra-articular hyaluronic acid injections are widely used for symptom relief, but their efficacy remains debated due to conflicting conclusions across systematic reviews and meta-analyses. This umbrella review assesses the symptomatic efficacy of intra-articular hyaluronic acid based on evidence reported by previously conducted systematic reviews and meta-analyses, identifies factors contributing to discrepancies in findings, and summarizes consistent outcome trends.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This umbrella review followed the Cochrane guidelines for overviews of reviews and adhered to the PRIOR reporting checklist. A systematic search was conducted in Medline (Ovid), the Cochrane Database of Systematic Reviews (Ovid CDSR), and Embase, using a predefined Population/Intervention/Comparator/Outcome/Study design (PICOS) framework. Systematic reviews of randomized controlled trials evaluating the efficacy of intra-articular hyaluronic acid on pain and/or function compared with placebo were included. Exclusion criteria were systematic reviews that included both randomized controlled trials and non-randomized controlled trials without separate synthesis of data from the former, scoping reviews, abstracts, commentaries, or narrative reviews. Two independent reviewers screened titles/abstracts, and full texts, resolving disagreements by consensus. Risk of bias was assessed using the AMSTAR-2 checklist, classifying systematic reviews as high, moderate, low, or critically low quality.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Twenty-two systematic reviews were included, with AMSTAR-2 quality ratings as follows: four high, one moderate, three low, and fourteen critically low. The majority (20/22) reported statistically significant beneficial effects of intra-articular hyaluronic acid injections on pain and function. However, according to the interpretation of their authors, fifteen systematic reviews concluded positively, three provided mixed interpretations, and four concluded negatively. All five of the reviews of high or moderate quality reported statistically significant beneficial effects, but with three concluding positively and two negatively. Negative or mixed conclusions were primarily attributed to restrictive inclusion criteria (e.g., analyses only of large trials, minimum patient numbers, long follow-up periods) and challenges in interpreting clinical relevance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Most systematic reviews and all high-quality systematic reviews support the symptomatic efficacy of intra-articular hyaluronic acid in knee osteoarthritis. Negative interpretations arise when restrictive inclusion criteria challenge the clinical relevance of results. However, given the methodological limitations, variability in review quality, and inconsistent interpretations, the overall certainty of evid","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108779"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle behaviors do not moderate the association between menopausal symptoms and need for recovery after work","authors":"Bette Loef ,&nbsp;Karin I. Proper ,&nbsp;Michelle G.A. Clevis ,&nbsp;MenoPause Consortium ,&nbsp;Irene G.M. van Valkengoed ,&nbsp;Karen Nieuwenhuijsen ,&nbsp;Sandra H. van Oostrom","doi":"10.1016/j.maturitas.2025.108757","DOIUrl":"10.1016/j.maturitas.2025.108757","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the moderating role of lifestyle behaviors (physical activity, alcohol use, smoking, and body mass index) in the association between menopausal symptoms and need for recovery after work in perimenopausal and postmenopausal women.</div></div><div><h3>Study design</h3><div>This study used cross-sectional survey data from 9942 perimenopausal and postmenopausal women participating in the Dutch Lifelines cohort in 2024. Measures included menopausal symptoms (measured with the Greene Climacteric Scale, GCS), lifestyle behaviors, need for recovery, and sociodemographic and work-related characteristics.</div></div><div><h3>Methods</h3><div>The association between menopausal symptoms and need for recovery was examined using logistic regression. Interaction terms between menopausal symptoms and lifestyle behaviors (physical activity, alcohol use, smoking, BMI) were added to test for moderation.</div></div><div><h3>Results</h3><div>Women with a 10-point higher GCS score had 4.51 times (95 %-CI = 4.17–4.87) greater odds of reporting a high need for recovery than women with a lower score. More hours of moderate-intensity (OR = 0.99, 95 %-CI = 0.98–0.996) and vigorous-intensity (OR = 0.91, 95 %-CI = 0.87–0.95) activity were associated with lower odds of high need for recovery, whereas higher BMI was associated with higher odds (OR = 1.02, 95 %-CI = 1.01–1.03). None of the lifestyle behaviors moderated the association between menopausal symptoms and need for recovery (all interaction terms <em>p</em> &gt; 0.10).</div></div><div><h3>Conclusions</h3><div>Menopausal symptoms were strongly associated with need for recovery after work. The findings suggest that high-risk groups based on physical activity, alcohol use, smoking, and BMI cannot be identified. The substantial impact of menopausal symptoms on need for recovery after work calls for prevention strategies targeting all perimenopausal and postmenopausal women, regardless of their lifestyle behaviors.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108757"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uterus debate in vaginal native tissue repair for pelvic organ prolapse: Hysteropexy versus hysterectomy – A systematic review and meta-analysis","authors":"Alessandro Ferdinando Ruffolo ,&nbsp;Stefano Salvatore ,&nbsp;Marco Torella ,&nbsp;Matteo Frigerio ,&nbsp;Marco Soligo ,&nbsp;Chrystele Rubod ,&nbsp;Marine Lallemant ,&nbsp;Michel Cosson ,&nbsp;Maurizio Serati ,&nbsp;Andrea Braga","doi":"10.1016/j.maturitas.2025.108755","DOIUrl":"10.1016/j.maturitas.2025.108755","url":null,"abstract":"<div><h3>Introduction</h3><div>Pelvic organ prolapse is a common condition with significant impact on women’s quality of life. Following restrictions on transvaginal mesh, native tissue repair has re-emerged as the mainstay of vaginal prolapse surgery. The role of hysterectomy in apical prolapse repair remains debated, with uterus-preserving techniques proposed as less invasive alternatives.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis according to PRISMA guidelines (PROSPERO CRD420251132469). Studies comparing vaginal hysterectomy with sacrospinous or uterosacral hysteropexy in native tissue repair were included. Primary outcomes were apical recurrence, global anatomical success, subjective success, and reoperation rates. Secondary outcomes included operative time, blood loss, hospital stay, and major complications. Random-effects models were used for statistical pooling.</div></div><div><h3>Results</h3><div>Sixteen studies involving 2544 women (1364 hysterectomy, 1180 hysteropexy) were analyzed. Pooled results showed no significant difference between hysterectomy and hysteropexy for apical recurrence (OR 0.60, 95 % CI 0.30–1.19), global anatomical success (OR 1.33, 95 % CI 0.88–2.02), subjective success (OR 0.92, 95 % CI 0.63–1.34), or reoperation rates (OR 1.04, 95 % CI 0.56–1.96). Similarly, no difference was observed in major complications (Clavien-Dindo ≥ III). However, hysterectomy was associated with longer operative time (+29 min), greater blood loss (+80 mL), and longer hospital stay (+1.1 days.</div></div><div><h3>Conclusions</h3><div>In vaginal native tissue repair for pelvic organ prolapse, hysterectomy and hysteropexy provide comparable anatomical and functional outcomes, as well as similar safety and reintervention rates. Hysteropexy appears advantageous in reducing perioperative morbidity and resource use, supporting its role as an effective, uterus-preserving alternative to hysterectomy.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108755"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-efficacy, quality of life, physical activity and educational interventions in menopausal women: A cross-sectional and pre–post study using Bayesian structural equation modelling","authors":"Daniele Magistro ,&nbsp;Roberto Vagnetti ,&nbsp;Paul Ansdell ,&nbsp;Jessica Piasecki","doi":"10.1016/j.maturitas.2025.108774","DOIUrl":"10.1016/j.maturitas.2025.108774","url":null,"abstract":"<div><h3>Objectives</h3><div>This two-part study aimed to confirm a theoretical model that integrates self-efficacy with menopause symptoms, quality of life and physical activity; and to determine the associations between self-efficacy and menopause knowledge following an education intervention.</div></div><div><h3>Study design</h3><div>The cross-sectional study involved 86 menopausal women (mean age = 55.57, SD = 7.44). Additionally, a pre–post design was employed after a half-day educational intervention (presentations, interactive polls and open discussions) with 51 women (mean age = 52.81, SD = 4.62).</div></div><div><h3>Main outcome measures</h3><div>The impact of menopausal symptoms on quality of life (QoL) was assessed via the Peri-menopausal Depression Scale and the Utian Quality of Life Scale. Physical activity was measured with the International Physical Activity Questionnaire. Self-efficacy was assessed with the General Self-Efficacy Scale. An ad hoc questionnaire pre- and post-events determined level of knowledge regarding menopause.</div></div><div><h3>Results</h3><div>Bayesian structural equation modelling confirmed the model. Physical activity exhibited a negative association with menopause symptoms (mean estimate = −1.69, 95 % CI [−3.08, −0.28]), and its relationship with quality of life (mean estimate = 1.35, 95 % CI [−0.24, 2.93]) was mediated by symptoms (mean estimate = 0.75, 95 % CIs [0.12, 1.51]). The detrimental impact of symptoms on quality of life (mean estimate = 4.42, 95 % CIs [2.22, 6.59]) was partially mediated by self-efficacy (mean estimate = −0.24, 95 % CIs [−0.38, −0.11]). Self-efficacy (<em>r</em> = 0.47, <em>p</em> &lt; .001) was significantly correlated with improvements in knowledge.</div></div><div><h3>Conclusions</h3><div>Increased physical activity could reduce menopausal symptoms and thereby enhance quality of life during the menopause. Higher levels of self-efficacy support better symptom management via improvements in menopause-related knowledge.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108774"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid use for performance and aesthetics in menopause and andropause: A contemporary dilemma","authors":"Jônatas de Oliveira ,&nbsp;Adriana Pereira ,&nbsp;Monique Cardoso Gonçalves","doi":"10.1016/j.maturitas.2025.108664","DOIUrl":"10.1016/j.maturitas.2025.108664","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108664"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early onset, maintenance of effect, and day-/night-time findings following fezolinetant treatment for moderate to severe vasomotor symptoms associated with menopause: A pooled phase 3 analysis","authors":"Marla Shapiro C.M. ,&nbsp;Genevieve Neal-Perry ,&nbsp;Petra Stute ,&nbsp;Rebecca C. Thurston ,&nbsp;Wendy Wolfman ,&nbsp;Marci English ,&nbsp;Xi Wu ,&nbsp;Faith D. Ottery","doi":"10.1016/j.maturitas.2025.108740","DOIUrl":"10.1016/j.maturitas.2025.108740","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate onset of action, maintenance of effect, day−/night-time efficacy, and treatment response with fezolinetant for the treatment of vasomotor symptoms (VMS) using phase 3 data.</div></div><div><h3>Study design</h3><div>SKYLIGHT 1 and 2 enrolled individuals (≥40–≤65 years) assigned female at birth who were seeking treatment/relief from moderate to severe VMS. Participants were randomised to placebo, or fezolinetant 30 or 45 mg for 12 weeks. Subsequently, fezolinetant-treated participants continued their dose and placebo participants were re-randomised to fezolinetant 30 or 45 mg for 40 weeks.</div></div><div><h3>Main outcome measures</h3><div>Daily frequency and severity of VMS during week 1, up to week 12, over 52 weeks, during the day and night; and proportion of responders.</div></div><div><h3>Results</h3><div>Improvements in VMS frequency and severity with fezolinetant versus placebo were observed from day 1 (1022 participants). At weeks 1 and 12, least squares mean (95 % confidence interval [CI]) reductions in VMS frequency for fezolinetant 45 mg versus placebo were − 1.46 (−2.01, −0.92) and − 2.51 (−3.20, −1.82). VMS frequency and severity improvements were maintained throughout 52 weeks and for both the day- and night-time assessments. A greater proportion of fezolinetant-treated participants had a reduction of ≥50 % in VMS frequency from baseline to week 12 versus placebo (58.7 % versus 36.0 %, odds ratio [95 % CI]: 2.542 [1.868–3.472]). Similar trends were noted with 30 mg.</div></div><div><h3>Conclusions</h3><div>The onset of action for fezolinetant was observed from day 1 for VMS frequency and severity and was maintained for 52 weeks. Fezolinetant can provide rapid and prolonged relief from VMS.</div></div><div><h3>Clinical trial registration</h3><div>SKYLIGHT 1</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>: <span><span>NCT04003155</span><svg><path></path></svg></span> (<span><span>https://clinicaltrials.gov/ct2/show/NCT04003155</span><svg><path></path></svg></span>).</div><div>SKYLIGHT 2</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>: <span><span>NCT04003142</span><svg><path></path></svg></span> (<span><span>https://clinicaltrials.gov/ct2/show/NCT04003142</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108740"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}