Maturitas最新文献

{"title":"Age-related differences in patient preferences for adjuvant chemotherapy for high-risk endometrial cancer","authors":"Famke C. Wakkerman ,&nbsp;Cathalijne C.B. Post ,&nbsp;Jan Willem M. Mens ,&nbsp;Ina M. Jürgenliemk-Schulz ,&nbsp;Friederike L.A. Koppe ,&nbsp;Marie A.D. Haverkort ,&nbsp;Ellen M.A. Roeloffzen ,&nbsp;An Snyers ,&nbsp;Marianne A.A. de Jong ,&nbsp;Eva E. Schaake ,&nbsp;Jannet C. Beukema ,&nbsp;Jeltsje Cnossen ,&nbsp;Mandy Kiderlen ,&nbsp;Ludy C.H.W. Lutgens ,&nbsp;Hans W. Nijman ,&nbsp;Cornelis D. de Kroon ,&nbsp;Judith R. Kroep ,&nbsp;Arwen H. Pieterse ,&nbsp;Carien L. Creutzberg ,&nbsp;Nanda Horeweg","doi":"10.1016/j.maturitas.2025.108805","DOIUrl":"10.1016/j.maturitas.2025.108805","url":null,"abstract":"<div><h3>Introduction</h3><div>Adjuvant chemotherapy in the treatment of endometrial cancer can be difficult to tolerate for older women. This study examined age-related differences in patient preferences for chemotherapy in women with high-risk endometrial cancer.</div></div><div><h3>Methods</h3><div>We re-analyzed data from the cross-sectional patient preference study PRETEC-2 to determine the difference between three age groups in minimally desired survival benefit of chemotherapy. For this, patients with high-risk endometrial cancer treated with adjuvant pelvic radiotherapy with or without chemotherapy completed a treatment trade-off questionnaire. Patients also rated the importance they attributed to treatment duration and acute and late side-effects for their decision on chemotherapy, which we analyzed by age group.</div></div><div><h3>Results</h3><div>A total of 171 patients (23% &lt;60 years, 40% 60–69 years and 37% ≥70 years) were included in the analysis. Older patients had a significantly higher median minimally desired survival benefit for preferring chemoradiotherapy (5% for &lt;60 years, 8% for 60–69 years and 15% for patients ≥70 years; (<em>p</em>&lt;0.001)), and had the largest variability in minimally desired survival benefit. For a real-life five-year survival benefit of 5%, fewer older patients preferred the addition of chemotherapy to their treatment regimen (61.5% for &lt;60 years, 45.6% for 60–69 years and 21.9% for ≥70 years; p&lt;0.001). Furthermore, older patients rated both treatment duration (<em>p</em>=0.001) and long-term tingling or numbness (<em>p</em>=0.005) as significantly more important than their younger counterparts.</div></div><div><h3>Conclusion</h3><div>There is more heterogeneity in the desired benefit of chemotherapy among patients aged 70 years or more compared to younger patients. This underlines the importance of recognizing individual differences and the need for shared decision-making.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108805"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter titled “Comment on the paper Effect of duration of hormonal contraceptive use on breast cancer risk: a systematic review and meta-analysis of cohort studies”","authors":"Carmen Sayon-Orea ,&nbsp;Miguel A. Martínez-González","doi":"10.1016/j.maturitas.2025.108801","DOIUrl":"10.1016/j.maturitas.2025.108801","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108801"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of life's essential 8 and life's crucial 9 scores with all-cause and cardiovascular mortality: A population-based cohort study of postmenopausal women","authors":"Jun Wei ,&nbsp;Ye Xu ,&nbsp;Yang Liu","doi":"10.1016/j.maturitas.2025.108753","DOIUrl":"10.1016/j.maturitas.2025.108753","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the associations of scores on the Life's Essential 8 (LE8) and Life's Crucial 9 (LC9) scales with all-cause and cardiovascular mortality among postmenopausal women in the United States.</div></div><div><h3>Methods</h3><div>We analyzed data from 5499 postmenopausal women aged ≥20 years from the 2005–2014 National Health and Nutrition Examination Survey (NHANES), linked to mortality data through December 31, 2019. LE8 includes four behavioral and four clinical metrics; LC9 adds psychological well-being. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause mortality. Generalized additive models explored dose–response relationships. Kaplan–Meier curves and log-rank tests assessed survival differences across score tertiles.</div></div><div><h3>Results</h3><div>During a median follow-up of 64 months, 1154 deaths occurred (20.99 %), including 358 (31.0 %) from cardiovascular causes. Mean LC9 score was 63.7 (SD = 14.2). Each 1-SD increase in LE8 and LC9 scores was associated with a 27 % (HR = 0.73, 95 % CI: 0.68–0.78) and 30 % (HR = 0.70, 95 % CI: 0.66–0.76) lower risk of all-cause mortality, respectively. Compared with the lowest tertiles, the highest tertiles of LE8 and LC9 were associated with 50 % (HR = 0.50, 95 % CI: 0.43–0.59) and 51 % (HR = 0.49, 95 % CI: 0.41–0.57) lower risks. Dose–response curves showed inverse, approximately linear associations. Kaplan–Meier survival curves showed significantly higher survival probabilities among participants with higher LE8 and LC9 scores (log-rank <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Higher LE8 and LC9 scores were associated with lower all-cause and cardiovascular mortality among postmenopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108753"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise intensity influences body composition: a 6-month comparison of high-intensity interval, moderate- and low-intensity training among healthy older adults","authors":"Grace Rose ,&nbsp;Emily Hume ,&nbsp;Daniel Blackmore ,&nbsp;Jules Mitchell ,&nbsp;Samuel Belford ,&nbsp;Tina Skinner ,&nbsp;Maryam Ziaei ,&nbsp;Stephan Riek ,&nbsp;Perry Bartlett ,&nbsp;Mia Schaumberg","doi":"10.1016/j.maturitas.2025.108763","DOIUrl":"10.1016/j.maturitas.2025.108763","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether exercise of higher intensity can elicit greater improvements in body composition among older adults, given that body composition is implicated in the progression of chronic disease.</div></div><div><h3>Study design</h3><div>Sub-study of a randomised controlled trial (ACTRN12618000700235).</div></div><div><h3>Main outcome measures</h3><div>Healthy older adults (<em>n</em> = 123, average age 72.0 years, body mass index 25.8 kg/m²) completed three 45-min supervised exercise sessions per week for 6 months. Participants were randomised to treadmill-based moderate-intensity training (<em>n</em> = 45), or high-intensity interval training (<em>n</em> = 41) or a low-intensity active control condition (<em>n</em> = 37), with individualised heart-rate prescription. Dual-energy x-ray absorptiometry was used to quantify body composition at baseline, and at 3 and 6 months.</div></div><div><h3>Results</h3><div>For fat mass, both high- (<em>p</em> = 0.001) and moderate-intensity groups (<em>p</em> = 0.016) demonstrated similar reductions that were both larger than control, post-intervention. Only moderate-intensity training was associated with reductions in fat-free mass (FFM) at 0–3 (<em>p</em> = 0.005) and 0–6 months (<em>p</em> = 0.050), potentially exacerbating age-related reductions in muscle and other lean tissues. Overall, high-intensity training had greater between-group raw difference in lean mass than moderate-intensity training at 6 months (<em>p</em> = 0.042) and this group was the only one with a net improvement in body fat percentage (<em>p</em> = 0.017). Moderate-intensity (<em>p</em> = 0.009) and high-intensity training (<em>p</em> = 0.023) demonstrated comparable improvements in visceral adipose tissue over 0–6 months.</div></div><div><h3>Conclusions</h3><div>High-intensity training reduced fat and maintained lean mass in apparently healthy older adults, though changes were small and not clinically meaningful compared with exercise of lower intensity and considering measurement error. Where appropriate and feasible, higher-intensity exercise training may be considered to support improvements in health-related body composition in older adults.</div><div>Protocol registration: ACTRN12618000700235.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108763"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-rated health and score on the item “caring about what goes on” on the sense of coherence scale as prospective predictors for all-cause mortality","authors":"Ilkka Piiroinen ,&nbsp;Ari Voutilainen","doi":"10.1016/j.maturitas.2025.108761","DOIUrl":"10.1016/j.maturitas.2025.108761","url":null,"abstract":"<div><div>Self-rated health and score on the item “caring about what goes on” from the Sense of Coherence scale were examined as predictors of all-cause mortality. Higher values on both measures (better health and caring more) predicted lower mortality among 2297 middle-aged men followed for 39 years. Fully adjusted hazard ratios (95 % confidence interval; <em>p</em>-value) were 0.86 (0.80–0.92; &lt;0.001) for self-rated health and 0.96 (0.93–0.99; 0.009) for caring. However, neither substantially improved the discriminatory power of conventional mortality predictors. Nevertheless, they may serve as age-adjusted predictors of mortality, particularly when clinical data are limited or when a comprehensive well-being assessment is desired.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108761"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145403465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of menopausal hormone therapy and physical activity on sexual function among postmenopausal women","authors":"Penghui Feng ,&nbsp;Lin Lin ,&nbsp;Zhuolin Xie ,&nbsp;Xiu Lin ,&nbsp;Jingbo Huang ,&nbsp;Shouqing Lin ,&nbsp;Min Luo ,&nbsp;Qi Yu ,&nbsp;Rong Chen","doi":"10.1016/j.maturitas.2025.108772","DOIUrl":"10.1016/j.maturitas.2025.108772","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the association between sexual function and both menopausal hormone therapy and physical activity among postmenopausal women.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, postmenopausal women who had used menopausal hormone therapy for at least three years were recruited as the intervention group, and those who had never used menopausal hormone therapy served as controls. Additionally, women were further categorized based on physical activity levels. All women were requested to complete the Female Sexual Function Index and the International Physical Activity Short Questionnaire for the Elderly surveys to evaluate their sexual function and physical activity levels.</div></div><div><h3>Results</h3><div>Application of the inclusion and exclusion criteria led to a sample size of 260 for the two study groups combined, 109 in the intervention group (who had used menopausal hormone therapy) and 151 in the control group (who had never used it). Our study revealed that menopausal hormone therapy was effective in alleviating sexual discomfort, with higher scores on the Female Sexual Function Index in the menopausal hormone therapy group compared with the control group (43.73 vs. 37.46, <em>P</em> &lt; 0.05). Specifically, users of menopausal hormone therapy experienced notable improvements in lubrication, orgasm, and overall satisfaction. Intriguingly, increased physical activity was associated with reduced sexual discomfort. Improved lubrication and pain relief were observed in the moderate- and high-exercise group receiving hormone therapy compared with controls.</div></div><div><h3>Conclusions</h3><div>Both menopausal hormone therapy and physical exercise were related to less sexual discomfort among women in this demographic. Additionally, menopausal hormone therapy appears to enhance the benefits of exercise in addressing sexual discomfort.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108772"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oestrogen receptor beta in breast cancer prognosis and treatment","authors":"Ana Božović ,&nbsp;Milica Nedeljković ,&nbsp;Bojana Kožik ,&nbsp;Lidija Todorović ,&nbsp;Milena Krajnović ,&nbsp;Snežana Jovanović-Ćupić ,&nbsp;Nikola Kokanov ,&nbsp;Milan Markićević ,&nbsp;Vesna Mandušić","doi":"10.1016/j.maturitas.2025.108762","DOIUrl":"10.1016/j.maturitas.2025.108762","url":null,"abstract":"<div><h3>Objectives</h3><div>About 30 % of breast cancer patients do not respond to adjuvant tamoxifen treatment. In addition to classical clinical and pathological parameters, treatment decisions are based on the presence of the oestrogen receptor alfa, the progesterone receptor, and human epidermal growth factor 2 receptor. The inclusion of novel biomarkers in the estimation of breast cancer prognosis and in treatment decision-making could help improve patient outcomes. The objective of this study was to test whether the oestrogen receptor beta is associated with breast cancer prognosis and/or treatment response.</div></div><div><h3>Study design</h3><div>We collected data from the 118 breast cancer patients who had undergone surgery at the Institute of Oncology and Radiology of Serbia from 2002 to 2004.</div></div><div><h3>Main outcome measures</h3><div>We collected clinicopathological, treatment and survival data from 2002 to 2022. The data about oestrogen receptor beta protein, oestrogen receptor beta 1 and delta 5 variant mRNA and the oestrogen receptor beta promoter ON region methylation index were determined in our previous studies. We used the Kaplan-Meier test and log-rank test to estimate survival rates and differences in survival between patient groups.</div></div><div><h3>Results</h3><div>In the exploratory subgroup analysis of patients with a high ERβ methylation index, tamoxifen use was associated with longer overall survival and disease-free survival (log-rank, <em>p</em> = 0.001; <em>p</em> = 0.033, respectively). In the subgroup of patients with a low ERβ methylation index, radiotherapy was associated with shorter disease-free survival (log-rank, <em>p</em> = 0.037).</div></div><div><h3>Conclusion</h3><div>This exploratory follow-up study investigates possible associations of oestrogen receptor beta expression and methylation with survival and treatment responses of breast cancer patients. Our results suggest that oestrogen receptor beta expression and methylation could be a significant additional marker of breast cancer prognosis to inform treatment decisions. These findings, derived from subgroup analyses, should be interpreted as hypothesis-generating and require validation in future studies.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108762"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in proteinuria and the risk of urogenital cancer in Korean men","authors":"Dong-Young Lee ,&nbsp;Min-Ho Kim ,&nbsp;Eunhee Ha ,&nbsp;Soonsu Shin ,&nbsp;Sungjin Kim ,&nbsp;Dosang Cho ,&nbsp;Ah Rah Lee ,&nbsp;Jae-Hong Ryoo","doi":"10.1016/j.maturitas.2025.108754","DOIUrl":"10.1016/j.maturitas.2025.108754","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the association between changes in proteinuria and the incidence of urogenital cancer (prostate, kidney, and bladder cancer) in Korean men.</div></div><div><h3>Methods</h3><div>We analyzed data from 1,225,646 Korean men who underwent health check-ups in 2005–2006 and 2009. Proteinuria changes were categorized into four groups based on urine dipstick tests: persistently negative, resolved, incident, and persistent proteinuria. The relationship between these groups and the incidence of urogenital cancer over follow-up through to 2021 was assessed using multivariate Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Persistent proteinuria was associated with the highest risk of urogenital cancer (hazard ratio (HR) 1.323, 95 % confidence interval (CI) 1.190–1.472), followed by incident proteinuria (HR 1.155, 95 % CI 1.096–1.217). Kidney cancer risk was elevated in persistent (HR 2.312, 95 % CI 1.853–2.885), incident (HR 1.346, 95 % CI 1.171–1.546), and resolved (HR 1.293, 95 % CI 1.066–1.568) proteinuria groups. Bladder cancer risk increased in the incident proteinuria group (HR 1.425, 95 % CI 1.289–1.576). Resolved proteinuria was linked to a reduced risk of prostate cancer (HR 0.878, 95 % CI 0.796–0.968).</div></div><div><h3>Conclusion</h3><div>The incidence of urogenital cancer was significantly higher for persistent proteinuria and (to a lesser degree) incident proteinuria than for persistently negative or resolved proteinuria. The risk of kidney cancer was similar to that of urogenital cancer, while other cancers had weaker associations with proteinuria. The results highlight the importance of monitoring proteinuria regularly for urogenital cancer risk assessment.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108754"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the clinical characteristics of possible REM sleep behavior disorder: a community-based study","authors":"Yuan Yuan ,&nbsp;Qihao Zhang ,&nbsp;Hui Zhang ,&nbsp;Yuan Li ,&nbsp;Jinghong Ma ,&nbsp;Hong Sun ,&nbsp;Jing An ,&nbsp;Qian Yu ,&nbsp;Wei Mao ,&nbsp;Piu Chan","doi":"10.1016/j.maturitas.2025.108759","DOIUrl":"10.1016/j.maturitas.2025.108759","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with rapid eye movement sleep behavior disorder (RBD) are considered to be at high risk of neurodegenerative diseases. RBD has been reported to be a male-predominant parasomnia and remains to be characterized in different population settings. We investigated sex-related differences in the prevalence, comorbidities, clinical characteristics, and prodromal neurodegenerative symptoms of possible RBD (pRBD) in a community-based cohort.</div></div><div><h3>Methods</h3><div>The validated RBD Questionnaire–Hong Kong (RBDQ-HK) was used to screen for pRBD among 7314 Chinese older adults (2881 men and 4433 women) in the Beijing Longitudinal Study on Aging (BLSA) II cohort. Demographic information, clinical features, prodromal non-motor symptoms, and subtle motor symptoms were assessed using established questionnaires.</div></div><div><h3>Results</h3><div>A total of 219 participants aged 55 or above were diagnosed with pRBD, of whom 60.27 % were women. The overall prevalence of pRBD was 3.03 %, with similar rates observed in men (3.06 %) and women (3.01 %). Women with pRBD were more likely to have a lower educational level (<em>p</em> &lt; 0.001), higher body mass index (<em>p</em> = 0.030), and higher prevalence of hypertension (<em>p</em> = 0.044) and cardiovascular disease (<em>p</em> = 0.045). They had more frequent sad dreams (<em>p</em> = 0.009) and poorer sleep quality (<em>p</em> = 0.045), whereas men were more prone to hurt themselves or their bed partners in dreams (<em>p</em> = 0.031 and <em>p</em> = 0.019, respectively). No sex difference was found in non-motor symptoms; however, a greater proportion of men reported reduced arm swing (<em>p</em> = 0.031).</div></div><div><h3>Conclusions</h3><div>In this community population-based study, we found that female participants with pRBD were less educated and exhibited fewer sleep-related injuries than males, which may lead to underreporting in clinical settings. However, males and females had a similar prevalence of prodromal neurodegenerative symptoms. Longitudinal studies are needed to further evaluate the sex differences in the risk of disease phenoconversion in isolated RBD patients in general populations.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108759"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary fiber intake with all-cause and cardiovascular mortality in postmenopausal U.S. women: A NHANES 1999–2018 cohort study","authors":"Yafei Guo ,&nbsp;Meiling Li ,&nbsp;Weihuang Zhuang","doi":"10.1016/j.maturitas.2025.108752","DOIUrl":"10.1016/j.maturitas.2025.108752","url":null,"abstract":"<div><h3>Background</h3><div>Dietary fiber is known to confer various health benefits, yet its impact on long-term mortality in older women remains under-explored. This study investigated the association between dietary fiber intake and the risk of all-cause and cardiovascular disease (CVD) mortality among postmenopausal U.S. women.</div></div><div><h3>Methods</h3><div>We analyzed 7708 postmenopausal participants from the 1999–2018 National Health and Nutrition Examination Survey (NHANES) linked to mortality data (median follow-up 121 months). Dietary fiber intake (grams/day) was assessed via 24-h dietary recalls. Cox proportional hazards models estimated hazard ratios (HRs) for all-cause and CVD mortality, adjusting for factors such as age, sex, ethnicity, education, poverty-income ratio, smoking, alcohol use, physical activity, and body mass index.</div></div><div><h3>Results</h3><div>The mean baseline dietary fiber intake was 14.75 ± 7.5 g/day. During follow-up, 2116 deaths (27.5 %) occurred, including 657 CVD deaths (8.5 %). Fiber intake was inversely associated with mortality risk. For those consuming less than 7.9 g/day, each 5 g/day increase in fiber was linked to a 7 % reduction in all-cause mortality risk (HR = 0.93). Above 7.9 g/day, benefits diminished (HR = 0.99). Women in the highest fiber tertile had significantly lower mortality risks than those in the lowest tertile (all-cause HR = 0.85; CVD HR = 0.69).</div></div><div><h3>Conclusion</h3><div>Higher dietary fiber intake is associated with reduced all-cause and CVD mortality, emphasizing the importance of adequate fiber consumption to older women's health and longevity.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108752"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145403490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}