Nanoscale Research Letters最新文献

Nanoparticles synthesized from green sources have attracted great recognition in the present times, which can be ascribed to their distinctive attributes and diversified applicability. Therefore, the present study employed Ocimum basilicum seed extract to synthesize silver nanoparticles. UV–vis spectrophotometry revealed strenuous peaks for different concentrations of silver nanoparticles ranging between 400 and 430 nm. The average crystal size calculated using X-ray diffraction analysis was 6.7 nm. Energy-dispersive X-ray analysis clearly displayed the presence of silver ions in the elemental structure of the synthesized nanoparticles. The morphology of synthesized nanoparticles revealed by scanning electron microscopy was documented in terms of spherical shape surrounded by an organic layer and nanoparticle size was estimated to be in between 10 and 80 nm. The nanoparticles exhibited substantial antibacterial activity against 46 foodborne bacterial isolates and 15 clinical isolates of Klebsiella pneumoniae, with the largest inhibition zones measuring 24 and 13 mm, respectively. Minimum inhibitory concentration values ranged between 500 and 800 µl/ml for various isolates. The antibacterial effect of all antibiotics revealed considerable enhancement when combined with nanoparticles. The calculated fractional inhibitory concentration index values were < 1 validating excellent synergism between nanoparticles and all antibiotics except ciprofloxacin against the majority of bacterial isolates. Interestingly, the biogenic nanoparticles showed significant antioxidant potential with IC₅₀ value of 165 µg/ml as well as anti-inflammatory activity with an IC₅₀ value of 82 µg/ml. Conclusively, the seed extract of Ocimum basilicum can be prospected for the development of antibacterial silver nanoparticles against pathogenic bacteria.

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In this work, we reported the synthesis of honey bee (Apis mellifera) venom-derived nanoparticles via a hydrothermal method. This method not only ensures the preservation of the bee venom’s bioactive components but also enhances their potential stability, thus broadening the scope for their applications in the biomedicinal field. The synthesis method started with the homogenization suspension of bee venom, followed by its hydrothermal process to synthesize bee venom nanoparticles (BVNPs). The successful synthesis of BVNPs was characterized using various characteristic techniques such as Ultraviolet–visible (UV–Vis) spectroscopy, Fourier Transforms Infrared (FTIR) Spectroscopy, Zeta Potential (ZP), Liquid Chromatography-Mass Spectrometry (LCMS), and Transmission Electron Microscopy (TEM). The synthesis of BVNPs through biosynthesis is shown by the visible violet-brown color development at 347 nm by UV–Vis spectroscopy. FTIR analysis revealed the presence of several functional groups in the BVNPs, including alcohols (–OH), phenols (C₆H₅–), carboxylic acids (–COOH), amines (–NH₂, –NH–), aldehydes (–CHO), ketones (–CO–), nitriles (–CN), amides (–CO–N–), imines (–CNH–), esters (–COO–), and polysaccharides. These functional groups, as confirmed by their specific stretching and bending vibrational modes, contribute to the diverse biological activities of BVNPs, including cytotoxicity against MCF-7 breast cancer cells. The ZP of the BVNPs indicated good colloidal stability at − 45 mV. LCMS analysis confirmed the presence of major bioactive molecules, including melittin & apamin and TEM analysis shows the BVNPs exhibited a quasi-spherical shape with good dispersion, the average size was approximately 25 nm, with some being smaller (quantum dots) and interplanar spacing of 0.236 nm indicated a highly ordered crystalline structure. Moreover, the anticancer efficacy of the BVNPs was ascertained through in vitro assays against MCF-7 breast cancer cells, showing a dose-dependent cytotoxic effect. The findings of this study underscore the viability of hydrothermal synthesis in producing biologically active and structurally stable BVNPs, with a significant potential for anticancer activities.

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The integration of green synthesis methods and advanced nanostructure designs holds significant promise for the development of innovative nanomaterials with diverse biomedical applications. This commentary delves into the use of barley grains for the eco-friendly synthesis of silver and gold nanoparticles, highlighting their potential as biocompatible agents with potent antibacterial properties. The barley-mediated synthesis approach not only offers a sustainable and cost-effective method for producing these nanoparticles but also underscores their remarkable efficacy against pathogenic bacteria. The barley-mediated approach not only offers a sustainable and cost-effective method for producing biocompatible nanoparticles but also demonstrates remarkable antibacterial efficacy against pathogenic bacteria. By critically evaluating the strengths and potential gaps in this synthesis approach, this commentary emphasizes the importance of integrating green synthesis techniques with advanced nanoparticle applications. Future research directions should aim at optimizing synthesis processes, ensuring enhanced stability and biocompatibility, and exploring the full potential of biologically synthesized nanoparticles in medical treatments and environmental sustainability. This focus on sustainable synthesis and application could pave the way for the next generation of nanomaterials, offering significant advancements in both healthcare and ecological preservation. By examining the strengths, gaps, and potential synergies between these two approaches, this commentary underscores the importance of sustainable synthesis techniques and the development of multifunctional nanoparticles. This integrated approach could lead to the creation of next-generation nanomaterials, offering significant advancements in medical treatments and environmental sustainability.

Hydroxyapatite (HA) is an extensively used biomaterial for dental and orthopaedic applications because of its biocompatibility and biomimetic nature. HA is extensively used as a bone-graft substitute. HA bone graft substitutes of bovine or synthetic origins have been extensively studied. However, caprine-based HA has not been explored. In this study, we aimed to determine the utilization of goat bone-derived HA for commercial applications. HA from caprine bone and teeth was isolated using thermal calcination. The developed HA can be used as a bone graft substitute. Chemical characterization of the isolated HA was carried out using Fourier transform infrared spectroscopy, X-Ray Diffraction, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. The biocompatibility and apatite formation of isolated HA were assessed using MG-63 cells, MC3T3-E1, L929 cells, MSCs, adipose derived stem cells, human dermal tissue derived fibroblast cells and osteoblast-like cell line, The studies demonstrate that HA support cell adhesion and osteogenic properties. To improve sheep, lamp, or caprine bone-derived HA, several other composites have been developed with MgO₂, ZrO_2, ZnO_2, and other polymeric substances. 3D printed technology was used to develop a bioink using sheep-derived HA and printed the composite scaffold as a bone graft substitute. Furthermore, the biomedical applications of sheep-derived HA been studied in terms of their antimicrobial activity, bone-forming ability, and wound healing applications. Sheep-, goat-, and caprine-derived HA are still underutilized and require further research to develop commercial possibilities and sustainable raw materials for HA-based bone graft substitutes.

Dynamic random-access memory (DRAM) has been scaled down to meet high-density, high-speed, and low-power memory requirements. However, conventional DRAM has limitations in achieving memory reliability, especially sufficient capacitance to distinguish memory states. While there have been attempts to enhance capacitor technology, these solutions increase manufacturing cost and complexity. Additionally, Silicon-based capacitorless memories have been reported, but they still suffer from serious difficulties regarding reliability and power consumption. Here, we propose a novel Schottky barrier memory (SBRAM), which is free of the complex capacitor structure and features a heterojunction based on bandgap engineering. SBRAM can be configured as vertical cross-point arrays, which enables high-density integration with a 4F² footprint. In particular, the Schottky junction significantly reduces the reverse leakage current, preventing sneak current paths that cause leakage currents and readout errors during array operation. Moreover, the heterojunction physically divides the storage region into two regions, resulting in three distinct resistive states and inducing a gradual current slope to ensure sufficient holding margin. These states are determined by the holding voltage (V_hold) applied to the programmed device. When the V_hold is 1.1 V, the programmed state can be maintained with an exceptionally low current of 35.7 fA without a refresh operation.

The auto-combustion method synthesized CuO NPs and Ag/CuO NPs. The Ag/CuO NPs were analyzed using Fourier-transform infrared, X-ray diffraction, scanning electron microscope, and Energy-dispersive X-ray spectroscopy instrumental analyses. The energy band gap, as determined by DRS properties, decreases from 3.82 to 3.50 eV for pure CuO and 10% Ag/CuO NPs, respectively. The photodegradation efficiency of Rhodamine-B & Carmine by 10% Ag/CuO NPs was nearly 98.9 and 97.8%, respectively. Antimicrobial trials revealed that the antimicrobial efficacy of Ag/CuO NPs at several dosages (20, 40, 60, 80, 100, and 120 µg/mL) against human pathogens was initially assessed using the agar well-diffusion method, and then the broth dilution method. Noticeably, the minimum inhibitory concentration of Ag/CuO NPs for all pathogens ranged from 100 to 120 µg/ml, was determined. Generally, the observed minimum microbicide concentration has a wide range of Ag/CuO NPs doses, ranging from 150 to 300 µg/ml, which helps kill (99.99%) all tested pathogenic cells. The largest relative inhibitory activities (%) were recorded against Escherichia coli (81.45 ± 1.39) at 120 g/mL of Ag/CuO NPs and 100 μg/mL (80.43 ± 0.59), followed by 80 µg/mL (72.33 ± 0.82). Additionally, the lowest relative inhibitory activities (%) were monitored versus fungal cells and Gram-positive bacteria at 120 µg/mL of Ag/CuO NPs as 52.17 ± 1.49 and 53.42 ± 1.71; respectively.

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Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health has coined the term "nanomedicine" to describe the use of nanotechnology in biological system monitoring, control, diagnosis, and treatment. Nanomedicine continues to receive increasing interest for the rationalized delivery of therapeutics and pharmaceutical agents to achieve the required response while reducing its side effects. However, as nanotechnology continues to advance, concerns about its potential toxicological effects have also grown. This review explores the current state of nanomedicine, focusing on the types of nanoparticles used and their associated properties that contribute to nanotoxicity. It examines the mechanisms through which nanoparticles exert toxicity, encompassing various cellular and molecular interactions. Furthermore, it discusses the assessment methods employed to evaluate nanotoxicity, encompassing in-vitro and in-vivo models, as well as emerging techniques. The review also addresses the regulatory issues surrounding nanotoxicology, highlighting the challenges in developing standardized guidelines and ensuring the secure translation of nanomedicine into clinical settings. It also explores into the challenges and ethical issues associated with nanotoxicology, as understanding the safety profile of nanoparticles is essential for their effective translation into therapeutic applications.

Antibiotic resistance is currently becoming a more serious threat to global health, especially in severe nosocomial infections treatment by multidrug-resistant bacteria. This research provides a new way of synergizing green-synthesis for zinc oxide quantum dots (ZnO-QDs with hexagonal crystals) that are 7 nm in diameter and zero-valent Ag cubic crystals that are 67 nm in size embedded with nitazoxanide substrate (NAZ). Instrumental characterization like SEM, TEM, EDAX, and FT-IR and comprehensive antimicrobial studies were conducted to study the incorporation behavior of composites based on Ag NPs/ZnO QDs/NAZ. This combination has not been hitherto addressed anywhere else in the published literature, as well as commercial viability. In this context, we have precisely tuned nanoparticle to nitazoxanide ratio for designing the formulation demonstrating potent activity against MDR infections. By employing nitazoxanide as a scaffold and careful decoration thereof antimicrobial potency has been unlocked overriding conventional therapies. In addition, Ag NPs/ZnO-QDs/nitazoxanide (G6) formula exhibited a therapeutic efficacy span of 96.15 ± 1.68% to 99.57 ± 0.20% against MDR human infections post 48 h incubation; a breakthrough in therapeutic efficacy levels has been achieved by our method. Accordingly, ZnO QDs/Ag NPs/NAZ composite offered potential multidrug resistant human pathogens as a new trend of revolutionizing antimicrobial treatment.

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Schematic diagram of synthesis routev ZnO quantum dots/Ag NPs/Nitazoxanide Triumphs composite NPs.

Under the dual pressures of environmental protection and energy security, the development and application of coal-based nanocarbon materials, supported by the technical concepts of molecular chemical engineering and nanomaterial science, is of significant importance for achieving the high-value clean utilization of coal. Furthermore, it serves as an effective means to assist in the realization of dual carbon goals. Coal, with its abundant reserves, high carbon content, and aromatic and hydrogenated aromatic groups, exhibits great advantages and potential in the synthesis of nanocarbon materials. In addition to its applications in traditional power and chemical industries, coal-based nanocarbon materials also demonstrate significant value in the field of environmental pollution control. This article succinctly summarizes the preparation methods and properties of coal-based carbon nanotubes, coal-based carbon quantum dots, and coal-based graphene, elucidates their current applications in water pollution control and governance, and anticipates their development trends in water pollution control, aiming to provide support for the clean and efficient utilization of coal and water pollution control.

Wound management spans various techniques and materials tailored to address acute and chronic non-healing wounds, with the primary objective of achieving successful wound closure. Chronic wounds pose additional challenges, often necessitating dressings to prepare the wound bed for subsequent surgical procedures like skin grafting. Ideal dressing materials should not only expedite wound healing but also mitigate protein, electrolyte, and fluid loss while minimizing pain and infection risk. Nanotechnology has emerged as a transformative tool in wound care, revolutionizing the landscape of biomedical dressings. Its application offers remarkable efficacy in accelerating wound healing and combating bacterial infections, representing a significant advancement in wound care practices. Integration of nanotechnology into dressings has resulted in enhanced properties, including improved mechanical strength and controlled drug release, facilitating tailored therapeutic interventions. This review article comprehensively explores recent breakthroughs in wound healing therapies, with a focus on innovative medical dressings such as nano-enzymes. Additionally, the utilization of smart materials, like hydrogels and electroactive polymers, in wound dressings offers dynamic functionalities to promote tissue regeneration. Emerging concepts such as bio-fabrication, microfluidic systems, bio-responsive scaffolds, and personalized therapeutics show promise in expediting wound healing and minimizing scarring. Through an in-depth exploration of these advancements, this review aims to catalyze a paradigm shift in wound care strategies, promoting a patient-centric approach to therapeutic interventions.