首页 > 最新文献

South African Journal of Psychiatry最新文献

英文 中文
Psychiatric nurses' knowledge of COVID-19 within a patient care context: A qualitative study. 精神科护士在病人护理背景下对COVID-19的了解:一项定性研究
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.4102/sajpsychiatry.v31i0.2344
Sandisiwe Dyonase, Isabelle Swanepoel, Gian Lippi

Background: Coronavirus disease 2019 (COVID-19) infection caused unparalleled hastening of the transmission of infection worldwide, commonly affecting healthcare workers' well-being. Nursing staff spend most hours caring for patients and are the first contact that patients utilise when reporting symptoms or receiving treatment.

Aim: This study aims to evaluate the knowledge of COVID-19 among psychiatric nurses at a tertiary psychiatric hospital.

Setting: Weskoppies Hospital, Gauteng, South Africa.

Methods: We conducted a qualitative study comprising 14 semi-structured interviews with nurses working at Weskoppies Hospital in South Africa. We used open-ended questions to facilitate the discussion and provide some structure for the interview while still allowing the participants to elaborate freely. The recordings were later transcribed into text.

Results: Twenty nurses working full time at the hospital, were recruited for the study. The nurses' knowledge about COVID-19 was summarised into five major themes, each with subthemes: signs and symptoms of COVID-19, risk of contracting the virus, the spread of COVID-19, prevention, and complications. In this study, the majority of participants had relatively good knowledge regarding COVID-19.

Conclusion: The majority of nurses at the hospital had adequate knowledge about COVID-19 but limited knowledge about the mode of transmission of the infection. Consistently improving healthcare workers' knowledge about infection control measures through training, supplying information and identifying areas for improvement can ultimately enhance patient care and outcomes.

Contribution: This study sheds light on the value of nurses' understanding of COVID-19, particularly in a psychiatric setting.

背景:2019冠状病毒病(COVID-19)感染在全球范围内造成了前所未有的感染传播加速,普遍影响到医护人员的健康。护理人员花费大部分时间照顾患者,并且是患者在报告症状或接受治疗时使用的第一个接触者。目的:了解某三级精神病院精神科护士对新冠肺炎相关知识的了解情况。地点:南非豪登省威斯科比医院。方法:我们对在南非Weskoppies医院工作的护士进行了一项定性研究,包括14个半结构化访谈。我们使用开放式问题来促进讨论,并为面试提供一些结构,同时仍然允许参与者自由阐述。这些录音后来被转录成文字。结果:招募了20名在医院全职工作的护士参与研究。将护士对COVID-19的知识总结为五大主题,每个主题分别为:COVID-19的体征和症状、感染病毒的风险、COVID-19的传播、预防和并发症。在这项研究中,大多数参与者对COVID-19有相对较好的了解。结论:该医院大多数护士对新冠肺炎有足够的知识,但对感染传播方式的了解有限。通过培训、提供信息和确定需要改进的领域,不断提高卫生保健工作者对感染控制措施的知识,最终可以改善患者护理和结果。贡献:本研究揭示了护士了解COVID-19的价值,特别是在精神科环境中。
{"title":"Psychiatric nurses' knowledge of COVID-19 within a patient care context: A qualitative study.","authors":"Sandisiwe Dyonase, Isabelle Swanepoel, Gian Lippi","doi":"10.4102/sajpsychiatry.v31i0.2344","DOIUrl":"10.4102/sajpsychiatry.v31i0.2344","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) infection caused unparalleled hastening of the transmission of infection worldwide, commonly affecting healthcare workers' well-being. Nursing staff spend most hours caring for patients and are the first contact that patients utilise when reporting symptoms or receiving treatment.</p><p><strong>Aim: </strong>This study aims to evaluate the knowledge of COVID-19 among psychiatric nurses at a tertiary psychiatric hospital.</p><p><strong>Setting: </strong>Weskoppies Hospital, Gauteng, South Africa.</p><p><strong>Methods: </strong>We conducted a qualitative study comprising 14 semi-structured interviews with nurses working at Weskoppies Hospital in South Africa. We used open-ended questions to facilitate the discussion and provide some structure for the interview while still allowing the participants to elaborate freely. The recordings were later transcribed into text.</p><p><strong>Results: </strong>Twenty nurses working full time at the hospital, were recruited for the study. The nurses' knowledge about COVID-19 was summarised into five major themes, each with subthemes: signs and symptoms of COVID-19, risk of contracting the virus, the spread of COVID-19, prevention, and complications. In this study, the majority of participants had relatively good knowledge regarding COVID-19.</p><p><strong>Conclusion: </strong>The majority of nurses at the hospital had adequate knowledge about COVID-19 but limited knowledge about the mode of transmission of the infection. Consistently improving healthcare workers' knowledge about infection control measures through training, supplying information and identifying areas for improvement can ultimately enhance patient care and outcomes.</p><p><strong>Contribution: </strong>This study sheds light on the value of nurses' understanding of COVID-19, particularly in a psychiatric setting.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"31 ","pages":"2344"},"PeriodicalIF":1.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding mental health support: Empowering medical professionals with greater resilience. 扩大心理健康支持:增强医疗专业人员的适应力。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI: 10.4102/sajpsychiatry.v31i0.2386
Yilin Jiang, Heng Zhou, Narina A Samah
{"title":"Expanding mental health support: Empowering medical professionals with greater resilience.","authors":"Yilin Jiang, Heng Zhou, Narina A Samah","doi":"10.4102/sajpsychiatry.v31i0.2386","DOIUrl":"10.4102/sajpsychiatry.v31i0.2386","url":null,"abstract":"","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"31 ","pages":"2386"},"PeriodicalIF":1.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 in patients with severe mental illness: An analysis of in-patients at a psychiatric hospital in Cape Town. 严重精神疾病患者的COVID-19:对开普敦一家精神病院住院患者的分析
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI: 10.4102/sajpsychiatry.v31i0.2286
Haseena B Sablay, Qhama Z Cossie, Deirdre I Pieterse

Background: Psychiatric patients in specialist units are more vulnerable to infections such as SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) because of hospital infrastructure and patients' mental health.

Aim: This study aimed to describe the psychiatric and medical profile, and the risk factors associated with more severe disease and clinical outcomes of coronavirus disease 2019 (COVID-19) in patients with severe mental illness (SMI) admitted to a specialist psychiatric hospital in South Africa between 01 April 2020 and 30 September 2021.

Setting: The study was executed at the Vàlkenberg Hospital (VBH), which is a government-funded, specialised psychiatric hospital. The hospital comprises 370 beds made up of 145 forensic service beds and 225 acute service beds. It provides in-patient and out-patient services.

Methods: Demographic and clinical information were collected for all VBH in-patients who tested positive for SARS-COV-2 from 01 April 2020 to 30 September 2021.

Results: A total of 254 participants tested positive for SARS-COV-2. The sample comprised 75% (n = 191) males with a mean age of 35.7 years. Most patients were diagnosed with schizophrenia (37%, n = 94), bipolar disorder (21%, n = 54) and schizoaffective disorder (19%, n = 49). Reported comorbidities included nicotine use (71%, n = 181), hypertension (11%, n = 28) and human immunodeficiency virus (7%, n = 18). Most patients (62%, n = 156) were symptomatic for COVID-19. Seven per cent (n = 17) required transfer to a medical ward. Almost all patients (99%, n = 252) recovered and 1% (n = 2) died.

Conclusion: Contrary to early fears of high mortality among institutionalised SMI patients, most experienced mild COVID-19 illness and recovered.

Contribution: This descriptive study provided information on in-patients with COVID-19 disease at a specialised psychiatric hospital during the pandemic.

背景:由于医院基础设施和患者的心理健康状况,专科病房的精神病患者更容易感染SARS-COV-2(严重急性呼吸综合征冠状病毒2)。目的:本研究旨在描述2020年4月1日至2021年9月30日期间南非一家专科精神病院收治的严重精神疾病(SMI)患者的精神病学和医学概况,以及与更严重疾病和2019冠状病毒病(COVID-19)临床结果相关的风险因素。环境:研究在Vàlkenberg医院(VBH)进行,这是一家政府资助的专业精神病医院。医院共有370张病床,其中法医病床145张,急症病床225张。它提供住院和门诊服务。方法:收集2020年4月1日至2021年9月30日所有SARS-COV-2检测阳性的VBH住院患者的人口学和临床信息。结果:共有254名参与者的SARS-COV-2检测呈阳性。样本中75% (n = 191)为男性,平均年龄为35.7岁。大多数患者被诊断为精神分裂症(37%,n = 94),双相情感障碍(21%,n = 54)和分裂情感障碍(19%,n = 49)。报告的合并症包括尼古丁使用(71%,n = 181),高血压(11%,n = 28)和人类免疫缺陷病毒(7%,n = 18)。大多数患者(62%,n = 156)有COVID-19症状。7% (n = 17)需要转到医务室。几乎所有患者(99%,n = 252)康复,1% (n = 2)死亡。结论:与入院的重度精神分裂症患者早期对高死亡率的担忧相反,大多数患者经历了轻微的COVID-19疾病并康复。贡献:本描述性研究提供了大流行期间在一家专业精神病院住院的COVID-19患者的信息。
{"title":"COVID-19 in patients with severe mental illness: An analysis of in-patients at a psychiatric hospital in Cape Town.","authors":"Haseena B Sablay, Qhama Z Cossie, Deirdre I Pieterse","doi":"10.4102/sajpsychiatry.v31i0.2286","DOIUrl":"10.4102/sajpsychiatry.v31i0.2286","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric patients in specialist units are more vulnerable to infections such as SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) because of hospital infrastructure and patients' mental health.</p><p><strong>Aim: </strong>This study aimed to describe the psychiatric and medical profile, and the risk factors associated with more severe disease and clinical outcomes of coronavirus disease 2019 (COVID-19) in patients with severe mental illness (SMI) admitted to a specialist psychiatric hospital in South Africa between 01 April 2020 and 30 September 2021.</p><p><strong>Setting: </strong>The study was executed at the Vàlkenberg Hospital (VBH), which is a government-funded, specialised psychiatric hospital. The hospital comprises 370 beds made up of 145 forensic service beds and 225 acute service beds. It provides in-patient and out-patient services.</p><p><strong>Methods: </strong>Demographic and clinical information were collected for all VBH in-patients who tested positive for SARS-COV-2 from 01 April 2020 to 30 September 2021.</p><p><strong>Results: </strong>A total of 254 participants tested positive for SARS-COV-2. The sample comprised 75% (<i>n</i> = 191) males with a mean age of 35.7 years. Most patients were diagnosed with schizophrenia (37%, <i>n</i> = 94), bipolar disorder (21%, <i>n</i> = 54) and schizoaffective disorder (19%, <i>n</i> = 49). Reported comorbidities included nicotine use (71%, <i>n</i> = 181), hypertension (11%, <i>n</i> = 28) and human immunodeficiency virus (7%, <i>n</i> = 18). Most patients (62%, <i>n</i> = 156) were symptomatic for COVID-19. Seven per cent (<i>n</i> = 17) required transfer to a medical ward. Almost all patients (99%, <i>n</i> = 252) recovered and 1% (<i>n</i> = 2) died.</p><p><strong>Conclusion: </strong>Contrary to early fears of high mortality among institutionalised SMI patients, most experienced mild COVID-19 illness and recovered.</p><p><strong>Contribution: </strong>This descriptive study provided information on in-patients with COVID-19 disease at a specialised psychiatric hospital during the pandemic.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"31 ","pages":"2286"},"PeriodicalIF":1.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From stroke to depression: The need for systematic screening for post-stroke depression. 从中风到抑郁:对中风后抑郁进行系统筛查的必要性。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2346
Mundih N Njohjam, Swirri S Nji, Ebsiy M Nongse

Background: Post-stroke depression (PSD) negatively impacts the physical and mental well-being of stroke survivors. However, data on the prevalence and risk factors of PSD in African countries such as Cameroon are limited.

Aim: This study aims to determine the prevalence and factors associated with PSD among stroke survivors at a hospital in Cameroon and inform clinical practice.

Setting: The study was carried out in the Nkwen Baptist Hospital in the North West region of Cameroon.

Methods: This was a hospital-based cross-sectional study. Stroke patients were systematically screened for PSD using the patient health questionnaire (PHQ-9). PSD was present if a patient scored ≥ 4 points on the scale. The multidimensional scale of perceived social support was used to assess the level of social support, the modified Rankin tool and Barthel index were used to assess functional independence, and the Fatigue assessment tool was used to assess post-stroke fatigue. A multivariate analysis was performed to identify factors associated with PSD.

Results: A total of 103 patients were included in the study. The mean age was 55.55 ± 12.15. Most patients were males (58.25%). The mean depression score was 5.17 ± 6.26. The overall prevalence of PSD was 36.89%. A higher functional impairment, post-stroke fatigue, perceived social support, recent stroke and being divorced were all associated with high PSD scores.

Conclusion: In this study, we found a high prevalence of PSD using a systematic screening approach, suggesting that systematic screening for PSD can lead to early detection and management.

Contribution: Systematic screening for PSD in stroke patients can lead to early diagnosis and, consequently, early initiation of treatment. Integration of mental health support and care as part of the routine stroke is warranted.

背景:脑卒中后抑郁(PSD)会对脑卒中幸存者的身心健康产生负面影响。然而,在喀麦隆等非洲国家,关于PSD患病率和风险因素的数据有限。目的:本研究旨在确定喀麦隆一家医院中风幸存者中ptsd的患病率和相关因素,并为临床实践提供信息。环境:该研究在喀麦隆西北地区的恩克温浸信会医院进行。方法:这是一项以医院为基础的横断面研究。采用患者健康问卷(PHQ-9)系统筛选脑卒中患者的PSD。如果患者在量表上得分≥4分,则存在PSD。采用感知社会支持多维度量表评估社会支持水平,采用改良Rankin工具和Barthel指数评估功能独立性,采用疲劳评估工具评估脑卒中后疲劳。进行多变量分析以确定与PSD相关的因素。结果:共纳入103例患者。平均年龄55.55±12.15岁。男性居多(58.25%)。平均抑郁评分为5.17±6.26。PSD总患病率为36.89%。较高的功能障碍、中风后疲劳、感知到的社会支持、最近中风和离婚都与高PSD得分有关。结论:在本研究中,我们通过系统筛查方法发现PSD的高患病率,提示系统筛查PSD可以早期发现和治疗。贡献:系统筛查卒中患者的PSD可导致早期诊断,因此,早期开始治疗。将心理健康支持和护理作为常规中风的一部分是必要的。
{"title":"From stroke to depression: The need for systematic screening for post-stroke depression.","authors":"Mundih N Njohjam, Swirri S Nji, Ebsiy M Nongse","doi":"10.4102/sajpsychiatry.v30i0.2346","DOIUrl":"10.4102/sajpsychiatry.v30i0.2346","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke depression (PSD) negatively impacts the physical and mental well-being of stroke survivors. However, data on the prevalence and risk factors of PSD in African countries such as Cameroon are limited.</p><p><strong>Aim: </strong>This study aims to determine the prevalence and factors associated with PSD among stroke survivors at a hospital in Cameroon and inform clinical practice.</p><p><strong>Setting: </strong>The study was carried out in the Nkwen Baptist Hospital in the North West region of Cameroon.</p><p><strong>Methods: </strong>This was a hospital-based cross-sectional study. Stroke patients were systematically screened for PSD using the patient health questionnaire (PHQ-9). PSD was present if a patient scored ≥ 4 points on the scale. The multidimensional scale of perceived social support was used to assess the level of social support, the modified Rankin tool and Barthel index were used to assess functional independence, and the Fatigue assessment tool was used to assess post-stroke fatigue. A multivariate analysis was performed to identify factors associated with PSD.</p><p><strong>Results: </strong>A total of 103 patients were included in the study. The mean age was 55.55 ± 12.15. Most patients were males (58.25%). The mean depression score was 5.17 ± 6.26. The overall prevalence of PSD was 36.89%. A higher functional impairment, post-stroke fatigue, perceived social support, recent stroke and being divorced were all associated with high PSD scores.</p><p><strong>Conclusion: </strong>In this study, we found a high prevalence of PSD using a systematic screening approach, suggesting that systematic screening for PSD can lead to early detection and management.</p><p><strong>Contribution: </strong>Systematic screening for PSD in stroke patients can lead to early diagnosis and, consequently, early initiation of treatment. Integration of mental health support and care as part of the routine stroke is warranted.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2346"},"PeriodicalIF":1.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intersection of depression and disability: A personal and professional perspective. 抑郁和残疾的交集:个人和专业的视角。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2429
Jean E Augustyn
{"title":"The intersection of depression and disability: A personal and professional perspective.","authors":"Jean E Augustyn","doi":"10.4102/sajpsychiatry.v30i0.2429","DOIUrl":"https://doi.org/10.4102/sajpsychiatry.v30i0.2429","url":null,"abstract":"","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2429"},"PeriodicalIF":1.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lifeworld of families of mental health care users in rural South Africa: A phenomenological study. 南非农村精神卫生保健使用者家庭的生活世界:一项现象学研究。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2280
Takalani E Mbedzi, Anna E van der Wath, Miriam M Moagi

Background: In recovery-oriented mental health care, family members of mental health care users form part of the caring team. Families are expected to care for mental health care users without support in the under-resourced rural Vhembe district in South Africa.

Aim: This study aims to describe the lifeworld of family members caring for mental health care users in rural areas to inform the development of a support programme.

Setting: Purposive sampling was used to select 16 family members from eight community health centres in the Vhembe district.

Methods: A qualitative approach, using a descriptive phenomenological design, was adopted to conduct unstructured interviews that were transcribed, translated and analysed using a descriptive method.

Results: Family members continuously contemplate their responsibilities. Endless concerns and stress result in forgetfulness and physical problems such as insomnia, hypertension and pain. Family members feel powerless and helpless when there is no improvement and support from community resources. Fear of being violated, embarrassed and stigmatised by community members results in social isolation and depression.

Conclusion: Caregiving is burdensome in poorly resourced areas. Feelings of helplessness and hopelessness Psychosomatic and depressive symptoms relate to the lack of effective community support which are likely to result in compromising the care they provide.

Contribution: The results call for the Department of Health to strengthen community mental health services and for health care professionals to provide supportive interventions based on the needs of mental health care users and their families.

背景:在以康复为导向的精神卫生保健中,精神卫生保健使用者的家庭成员是护理团队的一部分。在资源不足的南非Vhembe农村地区,预计家庭将在没有支持的情况下照顾精神保健使用者。目的:本研究旨在描述照顾农村地区精神卫生保健使用者的家庭成员的生活世界,为制定支持方案提供信息。环境:采用有目的抽样方法,从Vhembe区的8个社区保健中心选择16名家庭成员。方法:采用定性方法,采用描述性现象学设计,进行非结构化访谈,使用描述性方法进行转录,翻译和分析。结果:家庭成员不断思考自己的责任。无休止的担忧和压力会导致健忘和身体问题,如失眠、高血压和疼痛。当社区资源没有改善和支持时,家庭成员感到无能为力和无助。害怕受到社区成员的侵犯、尴尬和侮辱,导致社会孤立和抑郁。结论:在资源匮乏地区,护理工作负担沉重。身心和抑郁症状与缺乏有效的社区支持有关,这可能导致他们提供的护理受到损害。贡献:研究结果呼吁卫生署加强社区精神卫生服务,并呼吁卫生保健专业人员根据精神卫生保健使用者及其家庭的需要提供支持性干预措施。
{"title":"The lifeworld of families of mental health care users in rural South Africa: A phenomenological study.","authors":"Takalani E Mbedzi, Anna E van der Wath, Miriam M Moagi","doi":"10.4102/sajpsychiatry.v30i0.2280","DOIUrl":"10.4102/sajpsychiatry.v30i0.2280","url":null,"abstract":"<p><strong>Background: </strong>In recovery-oriented mental health care, family members of mental health care users form part of the caring team. Families are expected to care for mental health care users without support in the under-resourced rural Vhembe district in South Africa.</p><p><strong>Aim: </strong>This study aims to describe the lifeworld of family members caring for mental health care users in rural areas to inform the development of a support programme.</p><p><strong>Setting: </strong>Purposive sampling was used to select 16 family members from eight community health centres in the Vhembe district.</p><p><strong>Methods: </strong>A qualitative approach, using a descriptive phenomenological design, was adopted to conduct unstructured interviews that were transcribed, translated and analysed using a descriptive method.</p><p><strong>Results: </strong>Family members continuously contemplate their responsibilities. Endless concerns and stress result in forgetfulness and physical problems such as insomnia, hypertension and pain. Family members feel powerless and helpless when there is no improvement and support from community resources. Fear of being violated, embarrassed and stigmatised by community members results in social isolation and depression.</p><p><strong>Conclusion: </strong>Caregiving is burdensome in poorly resourced areas. Feelings of helplessness and hopelessness Psychosomatic and depressive symptoms relate to the lack of effective community support which are likely to result in compromising the care they provide.</p><p><strong>Contribution: </strong>The results call for the Department of Health to strengthen community mental health services and for health care professionals to provide supportive interventions based on the needs of mental health care users and their families.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2280"},"PeriodicalIF":1.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality rate in patients in a long-term psychiatric care facility in Johannesburg. 约翰内斯堡一家长期精神病护理机构病人的死亡率。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-27 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2329
Mokgokong Mathekga, Nokhutula Mdaka, Mvuyiso Talatala

Background: Limited research exists on mortality rates and contributing factors among individuals with severe mental illness (SMI) in long-term psychiatric care, especially in low- and middle-income countries (LMICs).

Aim: To analyse mortality rates and associated factors at Solomon Stix Morewa Memorial Hospital (SSMMH), a long-term psychiatric care facility in Johannesburg, South Africa.

Setting: SSMMH, a private facility in Selby Park, Johannesburg, has been contracted by the Gauteng Department of Health since March 2017 to provide inpatient care for SMI patients.

Methods: A retrospective analysis was conducted on records of 406 SMI patients admitted to SSMMH from March 2017 to February 2022. Mortality rates were calculated, and associated factors were analysed using descriptive statistics and logistic regression.

Results: Of the 406 participants, 34 (8%) died over five years, yielding a standardised mortality ratio (SMR) of 1.28 (95% CI: 0.85-1.71). Mortality was highest in the 60-69 years age group (SMR 2.7), with most deaths occurring in 2020-2021, likely due to COVID-19. Cardiovascular conditions were the leading cause of death (53%). Age at admission (OR: 2.35, 95% CI: 1.55-3.58) and transfer site (OR: 0.58, 95% CI: 0.42-0.81) were significant predictors of mortality.

Conclusion: Individuals with SMI face elevated mortality rates, with age, diagnosis, and comorbidities as key factors.

Contribution: This study provides insights into the comprehensive management of people with SMI to reduce mortality. Further research is needed to guide psychosocial and palliative care approaches.

背景:关于长期精神科护理中严重精神疾病(SMI)患者的死亡率及其影响因素的研究有限,特别是在低收入和中等收入国家(LMICs)。目的:分析南非约翰内斯堡一家长期精神病护理机构——所罗门·斯提克斯·莫雷瓦纪念医院(SSMMH)的死亡率及其相关因素。环境:SSMMH是约翰内斯堡塞尔比公园的一家私人机构,自2017年3月以来一直与豪登省卫生部签订合同,为SMI患者提供住院护理。方法:回顾性分析2017年3月至2022年2月入住SSMMH的406例重度精神障碍患者的记录。计算死亡率,并使用描述性统计和逻辑回归分析相关因素。结果:在406名参与者中,34人(8%)在5年内死亡,标准化死亡率(SMR)为1.28 (95% CI: 0.85-1.71)。60-69岁年龄组的死亡率最高(SMR为2.7),大多数死亡发生在2020-2021年,可能是由于COVID-19。心血管疾病是死亡的主要原因(53%)。入院年龄(OR: 2.35, 95% CI: 1.55-3.58)和转移地点(OR: 0.58, 95% CI: 0.42-0.81)是死亡率的重要预测因素。结论:重度精神分裂症患者死亡率升高,年龄、诊断和合并症是关键因素。贡献:本研究为重度精神障碍患者的综合管理提供了见解,以降低死亡率。需要进一步的研究来指导社会心理和姑息治疗方法。
{"title":"Mortality rate in patients in a long-term psychiatric care facility in Johannesburg.","authors":"Mokgokong Mathekga, Nokhutula Mdaka, Mvuyiso Talatala","doi":"10.4102/sajpsychiatry.v30i0.2329","DOIUrl":"10.4102/sajpsychiatry.v30i0.2329","url":null,"abstract":"<p><strong>Background: </strong>Limited research exists on mortality rates and contributing factors among individuals with severe mental illness (SMI) in long-term psychiatric care, especially in low- and middle-income countries (LMICs).</p><p><strong>Aim: </strong>To analyse mortality rates and associated factors at Solomon Stix Morewa Memorial Hospital (SSMMH), a long-term psychiatric care facility in Johannesburg, South Africa.</p><p><strong>Setting: </strong>SSMMH, a private facility in Selby Park, Johannesburg, has been contracted by the Gauteng Department of Health since March 2017 to provide inpatient care for SMI patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on records of 406 SMI patients admitted to SSMMH from March 2017 to February 2022. Mortality rates were calculated, and associated factors were analysed using descriptive statistics and logistic regression.</p><p><strong>Results: </strong>Of the 406 participants, 34 (8%) died over five years, yielding a standardised mortality ratio (SMR) of 1.28 (95% CI: 0.85-1.71). Mortality was highest in the 60-69 years age group (SMR 2.7), with most deaths occurring in 2020-2021, likely due to COVID-19. Cardiovascular conditions were the leading cause of death (53%). Age at admission (OR: 2.35, 95% CI: 1.55-3.58) and transfer site (OR: 0.58, 95% CI: 0.42-0.81) were significant predictors of mortality.</p><p><strong>Conclusion: </strong>Individuals with SMI face elevated mortality rates, with age, diagnosis, and comorbidities as key factors.</p><p><strong>Contribution: </strong>This study provides insights into the comprehensive management of people with SMI to reduce mortality. Further research is needed to guide psychosocial and palliative care approaches.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2329"},"PeriodicalIF":1.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and attitudes towards electroconvulsive therapy in an academic psychiatric department. 学术精神科对电休克疗法的认识和态度。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-21 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2302
Lerato L Masenya, Yvette M Nel

Background: Negative attitudes towards electroconvulsive therapy (ECT) among health professionals have been attributed to a lack of knowledge, despite advancements in its administration and evidence of its efficacy in certain psychiatric conditions.

Aim: This study assesses knowledge and attitudes towards ECT among psychiatry and clinical psychology professionals.

Setting: The University of the Witwatersrand, Department of Psychiatry, Johannesburg, South Africa.

Methods: A quantitative cross-sectional design was used. All psychiatry and clinical psychology professionals associated with the university were invited to participate in an anonymous online survey from 01 September 2022 to 30 June 2023.

Results: The response rate was 49.6% (n = 58) among psychiatrits and 22.2% (n = 22) among clinical psychology professionals. Psyhiatrists had greater knowldge and more favourable attitudes than psychologists. Only 45.5% of psychologists had exposure to ECT, compared to 93.1% of psychiatrists. Knowledge and attitude scores were significanly correlated (p = 0.009, OR 6.7). Most psychologists (86.4%) recommended ECT theory be included in their curriculum.

Conclusion: Greater knowledge correlates with improved attitudes towards ECT. Increased training could enhance attitudes, particularly among psychology professionals.

Contribution: This study offers insights into knowledge and attitudes towarss ECT in a Johannesburg psychiatry department.

背景:卫生专业人员对电痉挛疗法(ECT)持消极态度的原因是缺乏相关知识,尽管电痉挛疗法的应用取得了进步,并且有证据表明电痉挛疗法对某些精神疾病有效。目的:本研究评估精神科及临床心理学专业人员对电痉挛疗法的知识及态度。地点:南非约翰内斯堡,威特沃特斯兰德大学精神病学系。方法:采用定量横断面设计。从2022年9月1日到2023年6月30日,所有与该大学有关的精神病学和临床心理学专业人员都被邀请参加了一项匿名在线调查。结果:精神科医师应答率为49.6% (n = 58),临床心理专业人员应答率为22.2% (n = 22)。精神科医生比心理学家有更多的知识和更有利的态度。只有45.5%的心理学家接触过电痉挛疗法,而精神科医生的比例为93.1%。知识与态度得分呈显著相关(p = 0.009, OR 6.7)。大多数心理学家(86.4%)建议将电痉挛疗法理论纳入他们的课程。结论:更多的知识与对电痉挛治疗态度的改善有关。增加培训可以提高态度,尤其是心理学专业人士。贡献:本研究提供了对约翰内斯堡精神科对电痉挛疗法的认识和态度的见解。
{"title":"Knowledge and attitudes towards electroconvulsive therapy in an academic psychiatric department.","authors":"Lerato L Masenya, Yvette M Nel","doi":"10.4102/sajpsychiatry.v30i0.2302","DOIUrl":"10.4102/sajpsychiatry.v30i0.2302","url":null,"abstract":"<p><strong>Background: </strong>Negative attitudes towards electroconvulsive therapy (ECT) among health professionals have been attributed to a lack of knowledge, despite advancements in its administration and evidence of its efficacy in certain psychiatric conditions.</p><p><strong>Aim: </strong>This study assesses knowledge and attitudes towards ECT among psychiatry and clinical psychology professionals.</p><p><strong>Setting: </strong>The University of the Witwatersrand, Department of Psychiatry, Johannesburg, South Africa.</p><p><strong>Methods: </strong>A quantitative cross-sectional design was used. All psychiatry and clinical psychology professionals associated with the university were invited to participate in an anonymous online survey from 01 September 2022 to 30 June 2023.</p><p><strong>Results: </strong>The response rate was 49.6% (<i>n</i> = 58) among psychiatrits and 22.2% (<i>n</i> = 22) among clinical psychology professionals. Psyhiatrists had greater knowldge and more favourable attitudes than psychologists. Only 45.5% of psychologists had exposure to ECT, compared to 93.1% of psychiatrists. Knowledge and attitude scores were significanly correlated (<i>p</i> = 0.009, OR 6.7). Most psychologists (86.4%) recommended ECT theory be included in their curriculum.</p><p><strong>Conclusion: </strong>Greater knowledge correlates with improved attitudes towards ECT. Increased training could enhance attitudes, particularly among psychology professionals.</p><p><strong>Contribution: </strong>This study offers insights into knowledge and attitudes towarss ECT in a Johannesburg psychiatry department.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2302"},"PeriodicalIF":1.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teaching transference focused psychotherapy to South African mental health practitioners. 向南非心理健康从业者教授以移情为重点的心理治疗。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2315
Henk S Temmingh, Iliana Fanidi, Craig Bracken, Tennyson Lee

Background: Personality disorders (PDs) are estimated to occur in 6.8% of South Africans and in 45% to 80% of clinical populations. Mental health practitioners often harbour negative attitudes and lack confidence in working with such patients. Brief training in transference focused psychotherapy (TFP) has been shown to improve attitudes and confidence in the management of clinical encounters with PD.

Aim: This study aimed to describe the characteristics of attendees at a brief TFP training workshop and determine the impact of training on attitudes and clinical confidence towards patients with PD.

Setting: We conducted two 3 h online workshops, spaced 1 week apart to staff at South African University training hospitals.

Methods: At baseline, participants (N = 41) completed questionnaires on demographics, perceived need for training, supervision adequacy and perceived confidence. At baseline and after the second session, the Attitude to Personality Disorder Questionnaire (APDQ) and the Clinical Confidence in Personality Disorder Questionnaire (CCPDQ) were completed. Longitudinal data were analysed using linear mixed-effects regression.

Results: In the completer sample (N = 13), there were significant improvements in the APDQ enthusiasm subscale (p = 0.029) and in clinical confidence (CCPDQ) (p = 0.032). The APDQ total and other subscales also showed improvements. Participants with higher baseline confidence were more likely to drop out.

Conclusion: Brief training in TFP can lead to significant improvements in attitude and confidence in managing patients with PD.

Contribution: This is the first study in the South African context demonstrating the potential value of brief teaching in TFP.

背景:人格障碍(pd)估计发生在6.8%的南非人和45%至80%的临床人群中。精神卫生从业人员在与这类病人打交道时往往持消极态度,缺乏信心。以移情为中心的心理治疗(TFP)的简短培训已被证明可以改善对PD临床遭遇管理的态度和信心。目的:本研究旨在描述一个简短的TFP培训研讨会的与会者的特征,并确定培训对PD患者的态度和临床信心的影响。环境:我们对南非大学培训医院的工作人员进行了两次3小时的在线讲习班,间隔1周。方法:在基线时,参与者(N = 41)完成人口统计、感知培训需求、监管充分性和感知信心问卷。在基线和第二次治疗后,分别完成人格障碍态度问卷(APDQ)和人格障碍临床信心问卷(CCPDQ)。纵向数据采用线性混合效应回归分析。结果:在完成者样本(N = 13)中,APDQ热情分量表(p = 0.029)和临床置信度(CCPDQ)有显著改善(p = 0.032)。APDQ总分和其他量表也有所改善。基线信心较高的参与者更有可能退出。结论:简短的TFP培训可显著改善PD患者管理的态度和信心。贡献:这是第一个在南非背景下证明简短教学在TFP中的潜在价值的研究。
{"title":"Teaching transference focused psychotherapy to South African mental health practitioners.","authors":"Henk S Temmingh, Iliana Fanidi, Craig Bracken, Tennyson Lee","doi":"10.4102/sajpsychiatry.v30i0.2315","DOIUrl":"10.4102/sajpsychiatry.v30i0.2315","url":null,"abstract":"<p><strong>Background: </strong>Personality disorders (PDs) are estimated to occur in 6.8% of South Africans and in 45% to 80% of clinical populations. Mental health practitioners often harbour negative attitudes and lack confidence in working with such patients. Brief training in transference focused psychotherapy (TFP) has been shown to improve attitudes and confidence in the management of clinical encounters with PD.</p><p><strong>Aim: </strong>This study aimed to describe the characteristics of attendees at a brief TFP training workshop and determine the impact of training on attitudes and clinical confidence towards patients with PD.</p><p><strong>Setting: </strong>We conducted two 3 h online workshops, spaced 1 week apart to staff at South African University training hospitals.</p><p><strong>Methods: </strong>At baseline, participants (<i>N</i> = 41) completed questionnaires on demographics, perceived need for training, supervision adequacy and perceived confidence. At baseline and after the second session, the Attitude to Personality Disorder Questionnaire (APDQ) and the Clinical Confidence in Personality Disorder Questionnaire (CCPDQ) were completed. Longitudinal data were analysed using linear mixed-effects regression.</p><p><strong>Results: </strong>In the completer sample (<i>N</i> = 13), there were significant improvements in the APDQ enthusiasm subscale (<i>p</i> = 0.029) and in clinical confidence (CCPDQ) (<i>p</i> = 0.032). The APDQ total and other subscales also showed improvements. Participants with higher baseline confidence were more likely to drop out.</p><p><strong>Conclusion: </strong>Brief training in TFP can lead to significant improvements in attitude and confidence in managing patients with PD.</p><p><strong>Contribution: </strong>This is the first study in the South African context demonstrating the potential value of brief teaching in TFP.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2315"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and effectiveness of methylphenidate ER multi-unit pellet system in ADHD patients: An open label study. 哌甲酯内啡肽多单位微丸系统治疗ADHD患者的安全性和有效性:一项开放标签研究。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.4102/sajpsychiatry.v30i0.2267
Renata Schoeman, Evelyn Y Lai, Anne-Marie Nel, Mashra Gani, Muhammed A Fulat, Akbar A Mahomed

Background: Attention deficit hyperactive disorder (ADHD) is a neurodevelopmental disorder occurring in children and adults. Pharmacotherapy remains the cornerstone of ADHD treatment. Stimulants such as methylphenidate are effective and have been one of the best studied and most frequently used treatment for ADHD. However, different delivery mechanisms and devices may potentially impact patient experience and real-life outcomes.

Aim: This study evaluated the effectiveness of Multiple-Unit Pellet System Delivered Extended-Release Methylphenidate (Contramyl XR) on symptom control and reported outcomes in ADHD patients, in a real-world setting.

Setting: A phase IV, open label, flexible dose, prospective, observational study conducted at six sites covering five provinces of South Africa.

Methods: About 119 participants with ADHD (both newly diagnosed [treatment-naïve] and methylphenidate-treated [switch-over] patients) were enrolled and initiated either on Contramyl XR or switched over from methylphenidate to Contramyl XR. Primary efficacy was assessed by Weiss Functional Impairment Rating Scale (WFIRS) over 12 weeks.

Results: In all, 117 participants completed the study (treatment-naïve patients: 46% [n = 55] and switch-over patients: 54% [n = 64]). Mean change from baseline in total WFIRS (95% confidence interval) was -17.7 (-21.1, -14.3; p < 0.001) at week 4 and -29.3 (-33.5, -25.2; p < 0.001) at week 12. At week 12, there was significant improvement in WFIRS scores, with treatment satisfaction reported by treatment-naïve patients. Switch-over patients also demonstrated comparable effectiveness.

Conclusion: Contramyl XR was found to be clinically effective either as de novo or as switch therapy. It was well tolerated, and all patients chose to continue with the treatment option.

Contribution: Despite distinct and different delivery mechanism of Contramyl XR, this study provides evidence for using it as an alternate treatment option versus reference methylphenidate, in both treatment-naïve and switch-over ADHD patients. Study participants willingness to continue Contramyl XR therapy post study, further strengthens the confidence on the effectiveness of Contramyl XR in managing ADHD patients.

背景:注意缺陷多动障碍(ADHD)是一种发生在儿童和成人中的神经发育障碍。药物治疗仍然是ADHD治疗的基石。像哌醋甲酯这样的兴奋剂是有效的,并且是研究得最好和最常用的治疗多动症的方法之一。然而,不同的输送机制和设备可能会影响患者的体验和现实生活中的结果。目的:本研究在现实环境中评估多单元颗粒系统递送缓释哌甲酯(Contramyl XR)对ADHD患者症状控制和报告结果的有效性。环境:这是一项IV期、开放标签、灵活剂量、前瞻性观察性研究,在南非5个省的6个地点进行。方法:约119名ADHD患者(包括新诊断的[treatment-naïve]和哌甲酯治疗的[切换]患者)入组,开始使用Contramyl XR或从哌甲酯切换到Contramyl XR。12周后,通过Weiss功能损伤评定量表(WFIRS)评估主要疗效。结果:总共有117名参与者完成了研究(treatment-naïve患者:46% [n = 55],切换患者:54% [n = 64])。总WFIRS与基线相比的平均变化(95%置信区间)为-17.7 (-21.1,-14.3;P < 0.001)和-29.3 (-33.5,-25.2;P < 0.001)。在第12周,WFIRS评分显著改善,treatment-naïve患者报告治疗满意度。转换患者也显示出相当的有效性。结论:Contramyl XR无论是作为新生治疗还是作为转换治疗,均具有良好的临床疗效。它的耐受性良好,所有患者都选择继续治疗方案。贡献:尽管Contramyl XR的给药机制不同,但本研究为在treatment-naïve和切换型ADHD患者中使用Contramyl XR作为替代治疗选择而不是参考哌甲酯提供了证据。研究参与者在研究结束后愿意继续使用Contramyl XR治疗,进一步增强了Contramyl XR治疗ADHD患者有效性的信心。
{"title":"Safety and effectiveness of methylphenidate ER multi-unit pellet system in ADHD patients: An open label study.","authors":"Renata Schoeman, Evelyn Y Lai, Anne-Marie Nel, Mashra Gani, Muhammed A Fulat, Akbar A Mahomed","doi":"10.4102/sajpsychiatry.v30i0.2267","DOIUrl":"10.4102/sajpsychiatry.v30i0.2267","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit hyperactive disorder (ADHD) is a neurodevelopmental disorder occurring in children and adults. Pharmacotherapy remains the cornerstone of ADHD treatment. Stimulants such as methylphenidate are effective and have been one of the best studied and most frequently used treatment for ADHD. However, different delivery mechanisms and devices may potentially impact patient experience and real-life outcomes.</p><p><strong>Aim: </strong>This study evaluated the effectiveness of Multiple-Unit Pellet System Delivered Extended-Release Methylphenidate (Contramyl XR) on symptom control and reported outcomes in ADHD patients, in a real-world setting.</p><p><strong>Setting: </strong>A phase IV, open label, flexible dose, prospective, observational study conducted at six sites covering five provinces of South Africa.</p><p><strong>Methods: </strong>About 119 participants with ADHD (both newly diagnosed [treatment-naïve] and methylphenidate-treated [switch-over] patients) were enrolled and initiated either on Contramyl XR or switched over from methylphenidate to Contramyl XR. Primary efficacy was assessed by Weiss Functional Impairment Rating Scale (WFIRS) over 12 weeks.</p><p><strong>Results: </strong>In all, 117 participants completed the study (treatment-naïve patients: 46% [<i>n</i> = 55] and switch-over patients: 54% [<i>n</i> = 64]). Mean change from baseline in total WFIRS (95% confidence interval) was -17.7 (-21.1, -14.3; <i>p</i> < 0.001) at week 4 and -29.3 (-33.5, -25.2; <i>p</i> < 0.001) at week 12. At week 12, there was significant improvement in WFIRS scores, with treatment satisfaction reported by treatment-naïve patients. Switch-over patients also demonstrated comparable effectiveness.</p><p><strong>Conclusion: </strong>Contramyl XR was found to be clinically effective either as de novo or as switch therapy. It was well tolerated, and all patients chose to continue with the treatment option.</p><p><strong>Contribution: </strong>Despite distinct and different delivery mechanism of Contramyl XR, this study provides evidence for using it as an alternate treatment option versus reference methylphenidate, in both treatment-naïve and switch-over ADHD patients. Study participants willingness to continue Contramyl XR therapy post study, further strengthens the confidence on the effectiveness of Contramyl XR in managing ADHD patients.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"30 ","pages":"2267"},"PeriodicalIF":1.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
South African Journal of Psychiatry
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1