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Midterm Outcomes of Elective Endovascular Aortic Repair in Octogenarians: When Is It Too Old? 80多岁老人择期血管内主动脉修复的中期结果:什么时候太老?
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-06-01 DOI: 10.29400/tjgeri.2023.342
G. Deniz, S. Mola, Bahadir Aytekin, G. Aşkın, Sabir Hasanzade, Naim Boran Tümer, H. Iscan
Introduction: Endovascular aortic repair outcomes in octogenarians remain unclear. We aim to investigate whether the results for octogenarians differ from those of the younger population in elective endovascular aortic repair. Materials and Methods: From January 2013 to January 2022, 313 patients were treated with elective endovascular aortic repairs. Patient demographics and perioperative and postoperative features were obtained from the hospital database. The primary goals were to explore the early mortality rates of patients aged 80 years and older and compare them with those under 80. The secondary goal was to analyze the comorbid factors. Results: A total of 245 patients were under 80 years old, and 68 patients were 80 years and older. The early mortality rate was 2.94% in the octogenarians and 0.81% in the rest, and there was no significant difference between the two (p = 0.24). However, being 80 years and older led to a significantly lower survival probability at the five-year follow-ups. The American Society of Anesthesiologists’ score was found to help predict late mortality risk and patient selection for elective endovascular aortic repair. Conclusion: As octogenarians are fragile and sensitive to complications, patient selection, careful consideration of life expectancy, and clinical assessment are key to repair. Furthermore, age should not be an independent exclusion criterion in the endovascular aortic repair treatment decision. Keywords: Aortic Aneurysm, Abdominal; Endovascular Procedure; Octogenarians.
80岁老人的血管内主动脉修复效果尚不清楚。我们的目的是调查80岁老人在选择性血管内主动脉修复中的结果是否与年轻人不同。材料与方法:2013年1月至2022年1月,313例患者行选择性血管内主动脉修复术。从医院数据库中获得患者人口统计资料和围手术期及术后特征。主要目的是探讨80岁及以上患者的早期死亡率,并将其与80岁以下患者进行比较。次要目的是分析合并症因素。结果:80岁以下245例,80岁及以上68例。80岁以上人群早期死亡率为2.94%,其余人群为0.81%,两者差异无统计学意义(p = 0.24)。然而,在五年的随访中,80岁及以上的患者生存率明显较低。美国麻醉医师协会的评分被发现有助于预测晚期死亡风险和选择性血管内主动脉修复的患者选择。结论:由于耄耋老人身体脆弱,对并发症敏感,患者选择、审慎考虑预期寿命和临床评估是修复的关键。此外,年龄不应作为血管内主动脉修复治疗决策的独立排除标准。关键词:主动脉瘤;腹部;血管内手术;八旬老人。
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引用次数: 0
Evaluation of hospitalized youngest-old, middle-old and oldest-old COVID-19 patients in terms of mortality and risk factors 住院中老年、中老年和老年COVID-19患者死亡率及危险因素评价
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-06-01 DOI: 10.29400/tjgeri.2023.346
U. Sönmez, Y. Özdemir, A. Emecen
Introduction: In the coronavirus disease 2019 (COVID-19) pandemic, severe disease is predominantly seen in advanced-aged patients. In our study, we evaluated hospitalized youngest-old (65–74 years), middle-old (75–84 years) and oldest-old (≥85 years) COVID-19 patients in terms of mortality and risk factors. Materials and Methods: This retrospective study included hospitalized COVID-19 patients aged 65 years and older. Demographic characteristics, such as age, gender and comorbid conditions, baseline blood oxygen saturation levels, the necessity of oxygen treatments (nasal cannula,oxygen mask/reservoir oxygen mask), condition of the patients(mild, moderate, severe), baseline laboratory findings as C-reactive protein , white blood cell counts, thrombocyte counts, lymphocyte counts, D-dimer, alanine aminotransferase, aspartate aminotransferase and ferritin levels, pulmonary involvement on computerized tomography, the increase in oxygen requirements, the status of going to the intensive care unit and the status of receiving corticosteroids were recorded. Factors associated with mortality were analyzed. Results: A total of 399 geriatric COVID-19 patients were included in this study: 214(53.6%) were female and 185 (46.4%) were male. The mean age of the patients was 75±7.87(min:65–max:96). In our study, the mortality rate was found to be higher in the middle-old and oldest-old groups than in the youngest-old group (p=0.01). Other factors associated with mortality were as follows: lower baseline oxygen saturation levels (p=0.03), necessity of higher oxygen treatment (p<0.01), higher pulmonary involvement on computerized tomography (p<0.01), corticosteroid use (p<0.01) and having Alzheimer’s disease (p=0.03). Conclusion: Our findings emphasize that older patients are more vulnerable to COVID-19 infection and require special attention. Keywords: Geriatrics; SARS-CoV-2; Mortality.
在2019冠状病毒病(COVID-19)大流行中,严重疾病主要见于老年患者。在我们的研究中,我们对住院的年轻(65-74岁)、中年(75-84岁)和老年(≥85岁)COVID-19患者的死亡率和危险因素进行了评估。材料与方法:本回顾性研究纳入65岁及以上住院的COVID-19患者。人口统计学特征,如年龄、性别和合并症、基线血氧饱和度水平、氧治疗的必要性(鼻插管、氧罩/水库氧罩)、患者的病情(轻度、中度、重度)、基线实验室结果如c反应蛋白、白细胞计数、血小板计数、淋巴细胞计数、d -二聚体、丙氨酸转氨酶、天冬氨酸转氨酶和铁蛋白水平;记录肺部计算机断层扫描的受累情况、需氧量的增加情况、去重症监护病房的情况和接受皮质类固醇的情况。分析与死亡率相关的因素。结果:共纳入399例老年COVID-19患者,其中女性214例(53.6%),男性185例(46.4%)。患者平均年龄75±7.87岁(最小65岁~最大96岁)。在我们的研究中,中老年组和最高龄组的死亡率高于最年幼组(p=0.01)。其他与死亡率相关的因素如下:较低的基线血氧饱和度(p=0.03)、需要高氧治疗(p<0.01)、计算机断层扫描肺部受累程度较高(p<0.01)、皮质类固醇使用(p<0.01)和患有阿尔茨海默病(p=0.03)。结论:我们的研究结果强调老年患者更容易感染COVID-19,需要特别关注。关键词:老年病学;SARS-CoV-2;死亡率。
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引用次数: 0
Comparison of breast cancer patients over the age of 70 and under the age of 35 癌症70岁以上与35岁以下患者的比较
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-06-01 DOI: 10.29400/tjgeri.2023.339
A. Akan, Semra Günay, R. Bademci, Necla Gürdal, Merve Nur Güven, O. Yalçın
Introduction: Although breast cancer is a type of cancer that is mainly seen in advanced ages, its incidence is increasing in early ages in developing countries. While advanced age may create limitations in treatment due to the person’s functional capacity and low life expectancy, treatments may be exaggerated at a young age due to the long-life expectancy and expectations from life. In this study, we aimed to examine possible differences in approach in two different age groups diagnosed with breast cancer. Materials and Methods: The retrospective study included 123 patients over the age of 70 or under 35 who applied to our hospital’s breast surgery outpatient clinic between 2016 and 2021 and were diagnosed with breast cancer. The patients’ complaints at the outpatient clinic, the histopathological features of the tumor, and the treatments applied were compared. Results: 64 (52%) of the patients included in the study were over 70 years old, and 59 (47%) were under 35 years old. Patients in both groups were applied to the outpatient clinic with a palpable mass. Histopathologically, invasive ductal cancer constituted the majority in both groups. While the elderly patients were lower grade and Estrogen receptor-positive, the younger patients were high grade, Estrogen receptor negative, and mostly triple negative. Conclusions: Regardless of age, breast cancer is a cancer type that can have better results with early diagnosis. While making the treatment decision the decision should be made according to the characteristics of the tumor, comorbidity, and life expectancy, regardless of the patient’s age. Keywords: Breast Neoplasms; Aged; Age Distribution; Therapeutics.
简介:虽然癌症是癌症的一种,主要发生在老年,但在发展中国家,其发病率在早期呈上升趋势。虽然由于人的功能能力和预期寿命低,高龄可能会对治疗造成限制,但由于预期寿命长和对生活的期望,年轻时的治疗可能会被夸大。在这项研究中,我们旨在检查被诊断为癌症的两个不同年龄组在方法上的可能差异。材料与方法:回顾性研究包括2016年至2021年期间在我院乳腺外科门诊申请并被诊断为乳腺癌症的123名70岁以上或35岁以下患者。比较患者在门诊的主诉、肿瘤的组织病理学特征和所采用的治疗方法。结果:纳入研究的患者中有64名(52%)年龄在70岁以上,59名(47%)年龄在35岁以下。两组患者均在门诊就诊,肿块明显,组织病理学上浸润性导管癌症占多数。老年患者级别较低,雌激素受体阳性,而年轻患者级别较高,雌激素受体阴性,大多为三阴性。结论:无论年龄大小,癌症是一种癌症类型,早期诊断可获得更好的结果。在做出治疗决定时,应根据肿瘤的特征、合并症和预期寿命做出决定,而不考虑患者的年龄。关键词:乳腺肿瘤;…岁年龄分布;治疗学。
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引用次数: 0
Evaluating the Role of Vertebral Anatomy Examination by Ultrasonography Before Administering Spinal Anesthesia in Geriatric Patients: A Prospective Randomized Trial 评估老年患者脊柱麻醉前超声检查椎体解剖的作用:一项前瞻性随机试验
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.333
Arda Işıker, M. Onay, A. Akcan, Ümit Akkemik, M. Güleç
Introduction: This study evaluated the importance of examining neuraxial anatomy by preprocedural ultrasonography to ensure effective spinal anesthesia administration, which can be technically challenging in geriatric patients owing to their physiological and pathological conditions. Materials and Methods: Geriatric patients with an American Society of Anesthesiologists’ physical classification of I–III undergoing elective surgery under spinal anesthesia were included. The patients were divided into two groups: the anatomical landmark-guided group and the ultrasound-assisted group. Spinal block application times, number of attempts and number of needle redirections were recorded. Results: Among the studied patients, 29 and 30 patients were included in the anatomical landmark-guided group and the ultrasound-assisted group groups, respectively. There was no significant difference in the mean age of the patients in the ultrasound-assisted group (74.6 ± 7.41 years) and the anatomical landmark-guided group (75.6 ± 7.52 years). Assisted procedure time and total operative time were significantly shorter in the anatomical landmark-guided group than in the ultrasound-assisted group (p<0.001 and p<0.05, respectively); however, spinal application times and number of trials and needle redirections were significantly lower in the ultrasound-assisted group than in the anatomical landmark-guided group (p<0.05 and p <0.05, respectively). Conclusion: Preprocedural ultrasonography before spinal anesthesia administration increases the first-attempt success rate and decreases the number of attempts and needle redirections in geriatric patients. Keywords: Geriatrics; Anesthesia, Spinal; Ultrasonography
导言:本研究评估了术前超声检查脊髓轴解剖的重要性,以确保有效的脊髓麻醉给药,由于老年患者的生理和病理条件,这在技术上具有挑战性。材料与方法:入选美国麻醉医师学会体格分类为I-III级的脊柱麻醉下择期手术的老年患者。将患者分为解剖标志引导组和超声辅助组。记录脊髓阻滞应用次数、尝试次数和针头重定向次数。结果:在所研究的患者中,解剖标志引导组29例,超声辅助组30例。超声辅助组(74.6±7.41岁)与解剖标志引导组(75.6±7.52岁)患者的平均年龄差异无统计学意义。解剖标志引导组辅助手术时间和总手术时间均显著短于超声辅助组(p<0.001和p<0.05);超声辅助组脊柱穿刺次数、试验次数和针重定向均明显低于解剖地标引导组(p<0.05)。结论:老年患者腰麻术前超声检查可提高第一次穿刺成功率,减少穿刺次数和穿刺针重定向。关键词:老年病学;脊髓麻醉;超声
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引用次数: 0
Relationship Between the Amount of Amalgam Filling and Cognition in Older Adults 老年人汞合金充填量与认知的关系
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.334
Savaş Özarslantürk, M. Naharci, N. Aydın, S. Karaoğlanoğlu, E. Oktay
Introduction: This study aimed to evaluate the relationship between dental amalgam filling and cognition in older adults. Materials and Methods: A total of 169 patients aged 65 years and above were recruited from a geriatric outpatient clinic. Their socio-demographic and chronic disease data were recorded. All patients underwent oral examinations. Amalgam filling index scores were calculated for individuals with amalgam fillings. The participants were divided into a study group [amalgam (+)] and a control group [amalgam (–)] based on their amalgam-filling statuses. For sub-analysis, the amalgam-filled group was categorised according to high (≥4.191) and low (<4.191) mean index scores. Standardised mini-mental test, clock drawing test and Lawton–Brody instrumental activities of daily living scale were conducted for all patients. Results: About 46.2% (n=78) of participants were female, mean age was 69.6 ± 6.3 years and 53.7% (n=89) had amalgam fillings. There was no significant difference in the standardised mini-mental test, clock drawing test and Lawton–Brody instrumental activities of daily living scale scores between the study and control groups (all p>0.05), or in all test scores between participants with high and low amalgam scores in the group with amalgam fillings. Conclusions: This study showed that dental amalgam fillings were not associated with cognitive decline in older adults. Keywords: Aged; Cognitive Dysfunction; Dental Amalgam.
简介:本研究旨在评估老年人牙汞合金充填与认知的关系。材料与方法:从某老年门诊共招募169例65岁及以上患者。记录了他们的社会人口统计学和慢性病数据。所有患者均行口腔检查。对使用汞合金充填物的个体计算汞合金充填指数得分。根据他们的汞合金填充状态,参与者被分为研究组[汞合金(+)]和对照组[汞合金(-)]。在亚分析中,汞合金填充组按照高(≥4.191)和低(0.05)进行分类,或者按照汞合金填充组中汞合金得分高和低的参与者之间的所有测试分数进行分类。结论:本研究表明,牙科汞合金填充物与老年人认知能力下降无关。关键词:年龄;认知功能障碍;银汞合金。
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引用次数: 0
A 30-DAY RISK ASSESSMENT OF GERIATRIC PATIENTS IN THE EMERGENCY DEPARTMENT: A COMPARISON OF ISAR AND TRST SCORES 急诊科老年患者30天风险评估:isar和TRST评分的比较
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.328
Savaş Sezi̇k
Introduction: The aim of this prospective observational study was to compare the predictive ability of the Triage Risk Stratification Tool and Identification of Seniors at Risk in identifying elderly people at risk of adverse outcomes (return to the emergency department, hospital admission, and death) within 30 days following discharge from the emergency department. Materials and Methods: 396 patients aged between 65 and 98 (mean 76.89±7.59) accessing the emergency department were evaluated over a 1-month period. Both screening tool were administered in the emergency department by emergency specialist physicians. Risk factors were assigned a score based on their regression co-efficient estimate and a total risk score was created. This score was evaluated for sensitivity and specificity. Results: Of the 396 participants, 198 (50%) were female. A significant correlation was not observed between risk of adverse outcomes and characteristics of the participant (p>0.005). The Identification of Seniors at Risk (cutoff of ≥3) was positive in 61.3% of the patients, whereas 79% were Triage Risk Stratification Tool-positive (cutoff of ≥2). The two scores were significantly correlated and had similar areas under the receiver operating characteristic curves in predicting hospital admission (Identification of Seniors at Risk, 0.63; Triage Risk Stratification Tool, 0.59). Conclusions: The predictive accuracy of the scoring systems for hospital admission after 30 days was significant at cutoff values of ≥3 for Identification of Seniors at Risk and ≥2 for Triage Risk Stratification Tool. The Identification of Seniors at Risk had slightly higher sensitivity and lower specificity than the Triage Risk Stratification Tool. Key Words: Emergency Service, Hospital; Geriatric Assessment; Risk Assessment; Aged.
引言:这项前瞻性观察性研究的目的是比较分诊风险分层工具和风险老年人识别在识别急诊科出院后30天内有不良后果风险(返回急诊科、入院和死亡)的老年人方面的预测能力。材料和方法:在一个月的时间里,对396名年龄在65岁至98岁之间(平均76.89±7.59)的急诊患者进行了评估。这两种筛查工具都是由急诊专科医生在急诊科使用的。风险因素根据其回归系数估计值进行评分,并创建总风险评分。评估该评分的敏感性和特异性。结果:396名参与者中,198名(50%)为女性。不良结果的风险与参与者的特征之间没有观察到显著的相关性(p>0.05)。61.3%的患者的风险老年人识别(临界值≥3)呈阳性,而79%的患者的分型风险分层工具呈阳性(临界值大于或等于2)。在预测住院方面,这两个评分显著相关,并且在受试者操作特征曲线下具有相似的区域(风险老年人识别,0.63;分类风险分层工具,0.59)有风险且≥2岁的老年人使用分类风险分层工具。与分类风险分层工具相比,识别高危老年人的敏感性略高,特异性略低。关键词:急救服务、医院;老年评估;风险评估;…岁
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引用次数: 0
Comparison Of The Effects Of Intraoperative Goal Directed And Conventional Fluid Management On The Inferior Vena Cava Collapsibility Index And Postoperative Complications In Geriatric Patients Operated From Proximal Femoral Nail Surgery 目标导向和常规液体管理对老年股骨近端甲手术患者下腔静脉塌陷指数和术后并发症影响的比较
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.329
Dilara Göçmen, C. Köksal, S. Abitağaoğlu, Arzu Yıldırım Ar
Introduction: Avoiding undesirable effects of hyper- and hypovolemia is important in geriatric hip fracture patients perioperatively. In our study, we aimed to compare the effects of intraoperative goal directed and conventional fluid therapy on inferior vena cava collapsibility index, postoperative complications and 30-day mortality in these patients. Materials and Methods: 60 patients aged 65 and over who underwent proximal femoral nail surgery were included in the study.Patients were randomized into two groups; Goal Directed and Conventional Therapy groups. Patients in the Goal Directed Therapy Group were monitored with a MostcareTm (Vygon, VytechHealth, Padova, Italy) haemodynamic monitor. Fluid therapy was applied by targeting Pulse Pressure Variation <10%, Stroke Volume Variation <13%. In the Conventional Therapy group fluid management was administered to the patients according to the 4-2-1 rule. Before anesthesia and leaving the recovery room, inferior vena cava collapsibility index measurements was performed by ultrasonography. Results: Postoperative inferior vena cava collapsibility index was higher in the Conventional group. Total administered crystalloid fluid volumes were similar in both the groups and more colloids were used in the Goal Directed Therapy group. Intraoperative urine output was observed more in the Goal Directed Therapy group. Postoperative hospital stay was shorter in the Goal Directed Therapy group. There was no significant difference in terms of 30-day mortality and postoperative complications. Conclusion: According to our study, intraoperative targeted fluid herapy provides optimal postoperative intravascular volume and shortened the postoperative hospital stay. Keywords: Femoral Fractures; Vena Cava, Inferior; Hemodynamic Monitoring; Fluid Therapy; Postoperative Complications.
导言:在老年髋部骨折患者围手术期避免高血容量和低血容量的不良影响是很重要的。在我们的研究中,我们旨在比较术中目标导向和常规液体治疗对这些患者下腔静脉塌陷指数、术后并发症和30天死亡率的影响。材料与方法:60例65岁及以上行股骨近端甲手术的患者。患者随机分为两组;目标导向和常规治疗组。目标导向治疗组患者使用MostcareTm (Vygon, VytechHealth, Padova, Italy)血流动力学监测仪进行监测。以脉压变化<10%,脑容量变化<13%为目标进行液体治疗。常规治疗组按4-2-1规则进行输液处理。麻醉前及出院前,超声检查下腔静脉坍缩指数。结果:常规组术后下腔静脉塌陷指数明显高于常规组。两组给予的总晶体液体体积相似,目标定向治疗组使用更多的胶体。目的导向治疗组术中尿量明显增加。目标导向治疗组术后住院时间较短。两组在30天死亡率和术后并发症方面无显著差异。结论:根据我们的研究,术中靶向液体治疗提供了最佳的术后血管内容量,缩短了术后住院时间。关键词:股骨干骨折;下腔静脉;血流动力学监测;液体治疗;术后并发症。
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引用次数: 0
Frailty and Related Factors in Elderly Patients with Chronic Kidney Disease 老年慢性肾病患者的衰弱及其相关因素
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.325
A. Alp, H. Elbi̇, Aysun Toraman
Introduction: Chronic kidney disease and frailty are two crucial clinical conditions increasing in prevalence globally. Both lead to severe complications that increase mortality and morbidity in patients. Conditions that may potentiate frailty in chronic kidney disease patients may complicate the follow-up of chronic disease and complicate long-term survival in this patient group. In this study, we aimed to evaluate frailty and related factors in chronic kidney disease patients over 65 years of age who were on dialysis and who were not. Materials and Methods: This cross-sectional study was carried out in geriatric chronic kidney disease patients followed in nephrology outpatient clinics or undergoing routine hemodialysis. Frailty was assessed using a scoring scale. Laboratory findings and their relationship with demographic and epidemiological data were investigated. Results: One hundred eighty-eight patients aged 65 and over were included in our study. Of the patients, 92 were female, and 96 were male. The mean age was 72.86 years. We found frailty in 82 patients (43.6%). Female gender, over 75 years old, under dialysis treatment, low-income status, and low education level were parameters significantly associated with frailty. In the regression analysis, we found that economic status and dialysis were variables that independently affected frailty in chronic kidney disease patients. Conclusions: In our study, the frequency of frailty was found to be high. Practical management and early assessment of frailty seem rational with the basic nephrological approach in patients with chronic kidney disease. Considering the high mortality rate among frail patients, we think these patients should be followed up more closely. Keywords: Frailty; Aged; Renal Insufficiency, Chronic.
慢性肾脏疾病和虚弱是全球患病率上升的两种关键临床疾病。两者都会导致严重的并发症,增加患者的死亡率和发病率。在慢性肾脏疾病患者中,可能增强虚弱的条件可能使慢性疾病的随访复杂化,并使该患者组的长期生存复杂化。在这项研究中,我们旨在评估65岁以上接受透析和不接受透析的慢性肾病患者的衰弱及其相关因素。材料和方法:本横断面研究在肾内科门诊或常规血液透析的老年慢性肾病患者中进行。虚弱程度采用计分量表进行评估。调查了实验室结果及其与人口统计学和流行病学数据的关系。结果:我们的研究纳入了188例65岁及以上的患者。其中女性92例,男性96例。平均年龄72.86岁。我们发现82例(43.6%)患者虚弱。女性、75岁以上、接受透析治疗、低收入和低教育水平是与衰弱显著相关的参数。在回归分析中,我们发现经济状况和透析是独立影响慢性肾病患者虚弱的变量。结论:在我们的研究中,发现虚弱的频率很高。实际管理和早期评估衰弱似乎合理的基本肾脏病方法的慢性肾脏疾病患者。考虑到体弱多病患者的高死亡率,我们认为应该对这些患者进行更密切的随访。关键词:脆弱;岁的;肾功能不全,慢性。
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引用次数: 0
The Effects of Low Flow and Normal Flow Desflurane Anesthesia on Liver and Renal Functions and Serum Cystatin C Levels in Geriatric Patients: A Prospective Randomized Controlled Study 低流量和正常流量地氟醚麻醉对老年患者肝肾功能和血清胱抑素C水平的影响:一项前瞻性随机对照研究
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.332
Afife GÜLER KOL, Hacı Yusuf Güneş
Introduction: Aging is a physiological process and the elderly population is increasing. In parallel to the increasing of the elderly population, the number of geriatric patients who required an invasive procedure or surgical intervention under anesthesia are also increasing. The geriatric patients who are frailty and have a loss of functional reserve in all organ systems are more sensitive to anesthetic agents. The purpose of this research was to investigate whether low flow desflurane anesthesia also affects hepatic and kidney functions, in elderly patients. Methods: After approval from the local ethics committee, the patients were divided into two groups; as the low flow desflurane anesthesia group and the normal flow desflurane anesthesia group using the closed-envelope method. Calibration and leakage tests of the anesthesia device (Primus, Drager) were performed before anesthesia. Heamodynamics parametres, peripheral oxygen saturation, and bispectral index monitoring were performed to all patients in operating room. The blood samples were collected before anesthesia induction, after surgery, and at the postoperative 24th hour. The serum alanine aminotransferase and aspartate aminotransferase levels were measured to assess the liver damage. The serum creatinine, blood urea nitrogen, and cystatin C levels were measured to assess the kidney function. Results: The serum alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and cystatin C levels and hemodynamic parameters, peripheral oxygen saturation and bispectral index values were similar in both groups. Conclusions: It was concluded that low-flow desflurane anesthesia does not adversely affect liver and kidney functions in geriatric patients and is as safe as normal-flow desflurane anesthesia. Keywords: Anesthesia; Cystatin C; Desflurane; Aged; Kidney; Liver.
老龄化是一个生理过程,老年人口在不断增加。随着老年人口的增加,需要在麻醉下进行有创手术或手术干预的老年患者数量也在增加。体弱多病和所有器官系统功能储备丧失的老年患者对麻醉剂更为敏感。本研究的目的是探讨低流量地氟醚麻醉是否也会影响老年患者的肝肾功能。方法:经当地伦理委员会批准,将患者分为两组;为低流量地氟醚麻醉组和正常流量地氟醚麻醉组,采用密闭包络法。麻醉前对麻醉装置(Primus, Drager)进行校准和泄漏试验。对所有患者进行血流动力学参数、外周血氧饱和度、双谱指标监测。分别于麻醉诱导前、手术后及术后24小时采集血样。测定血清丙氨酸转氨酶和天冬氨酸转氨酶水平,评估肝损害程度。测定血清肌酐、尿素氮、胱抑素C水平评价肾功能。结果:两组患者血清丙氨酸转氨酶、天冬氨酸转氨酶、尿素氮、肌酐、胱抑素C水平及血流动力学参数、外周血氧饱和度、双谱指数均无明显差异。结论:低流量地氟醚麻醉对老年患者的肝肾功能没有不良影响,与正常流量地氟醚麻醉一样安全。关键词:麻醉;半胱氨酸蛋白酶抑制物C;地氟醚;岁的;肾脏;肝脏。
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引用次数: 0
Efficacy of Epidural Steroid Injection in Elderly Patients: Does Diagnosis Affect Treatment Success? 硬膜外类固醇注射对老年患者的疗效:诊断是否影响治疗成功?
IF 0.3 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-03-01 DOI: 10.29400/tjgeri.2023.327
Yücel Olgun, Rekib Saçaklıdır, Yasin Okumuş, Savaş Şencan, O. Gündüz
Introduction: Epidural steroid injections are a preferred interventional pain treatment for patients with low back pain. Our aim was to investigate the effectiveness of epidural steroid injections treatment in elderly patients and to examine the effect of patients’ diagnosis on the treatment success. Materials and Methods: Patients over the age of 65 who underwent epidural injections between January 2020 and January 2022 were retrospectively screened. The patients were divided into three groups according to their diagnosis: disc herniation, spinal stenosis, and failed back surgery syndrome. Numeric rating scale scores of all patients before the procedure, at three weeks, and at three months were noted. Results: A total of 234 patients were included in the study. Of these, 89 had disc herniation, 98 had spinal stenosis, and 47 had a history of failed back surgery. There were no significant differences between the groups in terms of age, gender, symptom duration, pre-procedural pain score, medical treatment, radiation dose, and procedure duration. Although a significant improvement was detected in pain scores at all follow-ups in all groups, these scores were found to be significantly lower in the disc herniation group than the spinal stenosis and failed back surgery groups at the three-week and month follow-ups. Conclusions: Epidural steroid injections has been found to be effective in back pain in elderly. In addition, elderly patients with disc herniation had a better response to treatment than those with spinal stenosis and failed back surgery. Further prospective and long-term follow-up studies are needed to support these results. Keywords: Aged; Low Back Pain; Injections, Epidural; Spinal Stenosis; Failed Back Surgery Syndrome.
引言:硬膜外类固醇注射是腰痛患者首选的介入性疼痛治疗方法。我们的目的是研究硬膜外类固醇注射治疗老年患者的有效性,并检查患者的诊断对治疗成功的影响。材料和方法:对2020年1月至2022年1月期间接受硬膜外注射的65岁以上患者进行回顾性筛查。根据诊断将患者分为三组:椎间盘突出、椎管狭窄和背部手术失败综合征。记录所有患者在手术前、三周和三个月时的数值评定量表得分。结果:本研究共纳入234例患者。其中,89人患有椎间盘突出症,98人患有椎管狭窄,47人有背部手术失败史。两组在年龄、性别、症状持续时间、术前疼痛评分、药物治疗、辐射剂量和手术持续时间方面没有显著差异。尽管在所有组的所有随访中,疼痛评分都有显著改善,但在三周和三个月的随访中,椎间盘突出组的疼痛评分明显低于椎管狭窄组和背部手术失败组。结论:硬膜外类固醇注射已被发现对老年人背痛有效。此外,与椎管狭窄和背部手术失败的患者相比,老年椎间盘突出患者对治疗的反应更好。需要进一步的前瞻性和长期随访研究来支持这些结果。关键词:老年人;腰痛;硬膜外注射;脊髓狭窄;背部手术失败综合症。
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引用次数: 1
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Turkish Journal of Geriatrics-Turk Geriatri Dergisi
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