Journal of Diabetes Investigation最新文献_第2页

Immune checkpoint inhibitor-related type 1 diabetes incidence, risk, and survival association 与免疫检查点抑制剂相关的 1 型糖尿病发病率、风险和存活率关联。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-21 DOI: 10.1111/jdi.14362

Fumika Kamitani, Yuichi Nishioka, Miyuki Koizumi, Hiroki Nakajima, Yukako Kurematsu, Sadanori Okada, Shinichiro Kubo, Tomoya Myojin, Tatsuya Noda, Tomoaki Imamura, Yutaka Takahashi

Aim/Introduction

Although immune checkpoint inhibitor-related type 1 diabetes mellitus (ICI-T1DM) is a rare condition, it is of significant concern globally. We aimed to elucidate the precise incidence, risk factors, and impact of ICI-T1DM on survival outcomes.

Materials and Methods

The study is a large retrospective cohort study, performed using the DeSC Japanese administrative claims database comprising 11 million patients. The database population is reportedly similar to the entire population of Japan. Patients administered ICI between 2014 and 2022 were enrolled in the study, including 21,121 patients. The risk factors for ICI-T1DM development and their characteristics were evaluated by logistic regression analysis. Development of a new irAE after the day following the first administration of ICI was set as the study outcome.

Results

ICI-T1DM was observed in 102 (0.48%) of the 21,121 patients after ICI initiation. PD-(L)1 and CTLA-4 combination therapy was associated with an increased risk of ICI-T1DM compared with PD-1 monotherapy (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.21–4.58; P = 0.01). Patients with a prior diagnosis of diabetes mellitus (OR, 1.59; 95% CI, 1.03–2.46; P = 0.04) or hypothyroidism (OR, 2.48; 95% CI, 1.39–4.43; P < 0.01) also exhibited an increased risk of ICI-T1DM. The Kaplan–Meier analysis revealed that patients with ICI-T1DM showed higher survival rates than those without (log-lank test, P < 0.01). Multivariable Cox regression analysis demonstrated that ICI-T1DM development was associated with lower mortality (hazard ratio, 0.60; 95% CI, 0.37–0.99; P = 0.04).

Conclusions

Collectively, the results of this study demonstrate the precise incidence and risk factors of ICI-T1DM. The development of ICI-T1DM, like other irAEs, is associated with higher survival rates.

目的/引言：尽管免疫检查点抑制剂相关1型糖尿病（ICI-T1DM）是一种罕见病，但它在全球范围内引起了极大关注。我们旨在阐明ICI-T1DM的确切发病率、风险因素以及对生存结果的影响：本研究是一项大型回顾性队列研究，使用的是由 1 100 万名患者组成的 DeSC 日本行政报销数据库。据报道，该数据库的人口与日本全国人口相似。2014年至2022年期间接受过ICI治疗的患者被纳入研究，其中包括21121名患者。通过逻辑回归分析评估了 ICI-T1DM 发生的风险因素及其特征。研究结果显示，在首次使用 ICI 后的第二天出现新的 irAE：结果：在开始使用 ICI 后的 21121 例患者中，有 102 例（0.48%）观察到 ICI-T1DM。与PD-1单药治疗相比，PD-(L)1和CTLA-4联合治疗与ICI-T1DM风险增加有关（几率比[OR]，2.36；95%置信区间[CI]，1.21-4.58；P = 0.01）。既往诊断为糖尿病（OR，1.59；95% CI，1.03-2.46；P = 0.04）或甲状腺功能减退症（OR，2.48；95% CI，1.39-4.43；P 结论：PD-1单药治疗与PD-1免疫治疗相比，疗效更佳：总之，本研究结果显示了 ICI-T1DM 的确切发病率和风险因素。与其他irAEs一样，ICI-T1DM的发生与较高的存活率相关。

{"title":"Immune checkpoint inhibitor-related type 1 diabetes incidence, risk, and survival association","authors":"Fumika Kamitani, Yuichi Nishioka, Miyuki Koizumi, Hiroki Nakajima, Yukako Kurematsu, Sadanori Okada, Shinichiro Kubo, Tomoya Myojin, Tatsuya Noda, Tomoaki Imamura, Yutaka Takahashi","doi":"10.1111/jdi.14362","DOIUrl":"10.1111/jdi.14362","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim/Introduction</h3>\u0000 \u0000 <p>Although immune checkpoint inhibitor-related type 1 diabetes mellitus (ICI-T1DM) is a rare condition, it is of significant concern globally. We aimed to elucidate the precise incidence, risk factors, and impact of ICI-T1DM on survival outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study is a large retrospective cohort study, performed using the DeSC Japanese administrative claims database comprising 11 million patients. The database population is reportedly similar to the entire population of Japan. Patients administered ICI between 2014 and 2022 were enrolled in the study, including 21,121 patients. The risk factors for ICI-T1DM development and their characteristics were evaluated by logistic regression analysis. Development of a new irAE after the day following the first administration of ICI was set as the study outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ICI-T1DM was observed in 102 (0.48%) of the 21,121 patients after ICI initiation. PD-(L)1 and CTLA-4 combination therapy was associated with an increased risk of ICI-T1DM compared with PD-1 monotherapy (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.21–4.58; <i>P</i> = 0.01). Patients with a prior diagnosis of diabetes mellitus (OR, 1.59; 95% CI, 1.03–2.46; <i>P</i> = 0.04) or hypothyroidism (OR, 2.48; 95% CI, 1.39–4.43; <i>P</i> < 0.01) also exhibited an increased risk of ICI-T1DM. The Kaplan–Meier analysis revealed that patients with ICI-T1DM showed higher survival rates than those without (log-lank test, <i>P</i> < 0.01). Multivariable Cox regression analysis demonstrated that ICI-T1DM development was associated with lower mortality (hazard ratio, 0.60; 95% CI, 0.37–0.99; <i>P</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Collectively, the results of this study demonstrate the precise incidence and risk factors of ICI-T1DM. The development of ICI-T1DM, like other irAEs, is associated with higher survival rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"334-342"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index 诊断 2 型糖尿病的新指标：胆固醇、高密度脂蛋白和葡萄糖（CHG）指数。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-21 DOI: 10.1111/jdi.14343

Amin Mansoori, Mina Nosrati, Mohsen Dorchin, Fatemeh Mohammadyari, Elahe Derakhshan-Nezhad, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

Background

Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low-income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus.

Methods

A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut-off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut-off of indices to evaluate the sensitivity and specificity of them.

Results

The best cut-off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus.

Conclusions

The CHG index could be useful for the detection of type 2 diabetes mellitus.

背景：2 型糖尿病的金标准方法价格昂贵，因此不适用于低收入国家的大规模研究。我们研究了用于诊断 2 型糖尿病的总胆固醇、高密度脂蛋白（HDL）和血糖（CHG）指数，该指数来自空腹状态。本研究旨在比较 CHG 指数与甘油三酯（TG）和葡萄糖水平（TyG）作为 2 型糖尿病替代指标的准确性：马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究共招募了 9704 名 35 至 65 岁的患者。他们被分为两组，即患有和未患有 2 型糖尿病的人群。各组检测 2 型糖尿病的临界值为血样中空腹血糖≥126 毫克/分升。采用接收者操作特征曲线（ROC）分析法确定指数的临界值，以评估其灵敏度和特异性：诊断 2 型糖尿病的最佳 CHG 指数临界值为 5.57，其敏感性为 70.38%，特异性为 89.82%。这是与 TyG 指数相比得出的结果。LR+ CHG 指数为 6.91，而 TyG 指数为 3.47；CHG 指数的 AUC 为 0.864 (0.857, 0.871)，而 TyG 指数为 0.825 (0.818, 0.833)。这表明 CHG 指数在诊断 2 型糖尿病方面具有更高的效率值：结论：CHG指数可用于检测2型糖尿病。

{"title":"A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index","authors":"Amin Mansoori, Mina Nosrati, Mohsen Dorchin, Fatemeh Mohammadyari, Elahe Derakhshan-Nezhad, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan","doi":"10.1111/jdi.14343","DOIUrl":"10.1111/jdi.14343","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low-income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut-off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut-off of indices to evaluate the sensitivity and specificity of them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The best cut-off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The CHG index could be useful for the detection of type 2 diabetes mellitus.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"309-314"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between nerve ultrasonography image and electrophysiology in diabetic polyneuropathy 糖尿病多发性神经病变中神经超声图像与电生理学之间的关系

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-21 DOI: 10.1111/jdi.14353

Pei-Chen Hsieh, Long-Sun Ro, Chun-Che Chu, Ming-Feng Liao, Hong-Shiu Chang, Hung-Chou Kuo

Aims/Introduction

This study aims to investigate the association between cross-sectional area (CSA) imaging findings of nerve ultrasound and conventional nerve conduction studies (NCS) for patients with distal symmetric sensorimotor polyneuropathy (DSPN) due to type 2 diabetes mellitus.

Materials and Methods

We enrolled 103 patients with type 2 diabetes mellitus and collected their demographic data, modified Michigan Neuropathy Screening Instrument (mMNSI) score, NCS, and ultrasonography images of peripheral nerves. The relationship of ultrasound variables for individual nerves and the ultrasound pattern sum score (UPSS) to conventional NCS findings was investigated.

Results

A higher grade of DSPN was associated with a notably higher CSA. Multivariate step-wise regression analysis revealed that the number of abnormal nerves was a positive independent variable for UPSS (β coefficient = 0.4205; P < 0.0001). Of the five nerves studied, abnormalities of the tibial nerve (P ≤ 0.0100) and ulnar nerve (P = 0.052) were the most significant variables.

Conclusions

The tibial nerve exhibited the most substantial association with elevated UPSS. In addition, a strong correlation was observed between abnormal NCS findings and UPSS in patients with DSPN.

目的/简介：本研究旨在探讨 2 型糖尿病导致的远端对称性感觉运动性多发性神经病（DSPN）患者的神经超声横截面积（CSA）成像结果与常规神经传导研究（NCS）之间的关联：我们招募了103名2型糖尿病患者，收集了他们的人口统计学数据、改良密歇根神经病变筛查工具（mMNSI）评分、NCS和外周神经超声图像。研究了单个神经的超声变量和超声模式总分（UPSS）与传统 NCS 结果的关系：结果：DSPN等级越高，CSA明显越高。多变量逐步回归分析表明，异常神经的数量是 UPSS 的一个正向自变量（β 系数 = 0.4205；P 结论：胫神经表现出最明显的畸形，而腓肠肌则表现出最明显的畸形：胫神经与 UPSS 升高的关系最为密切。此外，在 DSPN 患者中，异常 NCS 结果与 UPSS 之间存在很强的相关性。

{"title":"Relationship between nerve ultrasonography image and electrophysiology in diabetic polyneuropathy","authors":"Pei-Chen Hsieh, Long-Sun Ro, Chun-Che Chu, Ming-Feng Liao, Hong-Shiu Chang, Hung-Chou Kuo","doi":"10.1111/jdi.14353","DOIUrl":"10.1111/jdi.14353","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>This study aims to investigate the association between cross-sectional area (CSA) imaging findings of nerve ultrasound and conventional nerve conduction studies (NCS) for patients with distal symmetric sensorimotor polyneuropathy (DSPN) due to type 2 diabetes mellitus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We enrolled 103 patients with type 2 diabetes mellitus and collected their demographic data, modified Michigan Neuropathy Screening Instrument (mMNSI) score, NCS, and ultrasonography images of peripheral nerves. The relationship of ultrasound variables for individual nerves and the ultrasound pattern sum score (UPSS) to conventional NCS findings was investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A higher grade of DSPN was associated with a notably higher CSA. Multivariate step-wise regression analysis revealed that the number of abnormal nerves was a positive independent variable for UPSS (<i>β</i> coefficient = 0.4205; <i>P</i> < 0.0001). Of the five nerves studied, abnormalities of the tibial nerve (<i>P ≤</i> 0.0100) and ulnar nerve (<i>P</i> = 0.052) were the most significant variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The tibial nerve exhibited the most substantial association with elevated UPSS. In addition, a strong correlation was observed between abnormal NCS findings and UPSS in patients with DSPN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"257-264"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced renoprotective effects of combined glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: Real-world evidence 联合使用胰高血糖素样肽-1 受体激动剂和钠-葡萄糖共转运体 2 抑制剂可增强 2 型糖尿病患者的肾保护作用：真实世界的证据。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-21 DOI: 10.1111/jdi.14361

Jian-Yu Jhu, Yu-Wei Fang, Chung-Yen Huang, Hung-Hsiang Liou, Mon-Ting Chen, Ming-Hsien Tsai

Introduction

Developing a more effective treatment for the global impact of diabetic kidney disease is crucial. This study examined the renoprotective effects of combining glucagon-like peptide-1 receptor agonists (GLP-1 RA) with sodium–glucose cotransporter 2 inhibitors (SGLT2i) compared to SGLT2is alone in type 2 diabetes (DM).

Materials and Methods

This retrospective cohort study used data from the TriNetX Global Collaborative Network. Type 2 DM patients with estimated glomerular filtration rates ≥60 mL/min/1.73 m² who used GLP-1 RA or SGLT2i between January 1, 2013, and December 31, 2023. Propensity score matching balanced baseline characteristics, resulting in 71,186 patients in each group (combined GLP-1 RA and SGLT2i therapy vs SGLT2i alone). Cox regression model was adopted to compare outcomes over a 5-year period, including major adverse kidney events (MAKE), acute kidney injury (AKI), end-stage kidney disease (ESKD), and all-cause mortality.

Results

After matching, the average age was 57.1 ± 10.8 years for the GLP-1 RA plus SGLT2i group and 57.2 ± 11.7 years for the SGLT2i-only group. The GLP-1 RA plus SGLT2i group had significantly lower risk of MAKE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.69–0.77), AKI (HR: 0.82, 95% C0I: 0.77–0.87), ESKD (HR: 0.61, 95% CI: 0.47–0.78), and all-cause mortality (HR: 0.54, 95% CI: 0.50–0.58) compared to the SGLT2i-only group. Moreover, subgroup analyses showed consistent benefits across different subgroups.

Conclusions

Dual therapy with GLP-1 RA and SGLT2i is supported to enhance renal outcomes and address the growing burden of diabetic kidney disease.

导言：针对糖尿病肾病的全球性影响，开发更有效的治疗方法至关重要。本研究考察了胰高血糖素样肽-1 受体激动剂（GLP-1 RA）与钠-葡萄糖共转运体 2 抑制剂（SGLT2i）联合治疗 2 型糖尿病（DM）与单独使用 SGLT2is 相比的肾保护作用：这项回顾性队列研究使用了 TriNetX 全球协作网络的数据。2013年1月1日至2023年12月31日期间使用GLP-1 RA或SGLT2i的估计肾小球滤过率≥60 mL/min/1.73 m2的2型DM患者。倾向评分匹配平衡了基线特征，每组（GLP-1 RA 和 SGLT2i 联合疗法 vs 单用 SGLT2i）共有 71186 名患者。采用 Cox 回归模型比较 5 年期间的结果，包括主要不良肾脏事件 (MAKE)、急性肾损伤 (AKI)、终末期肾病 (ESKD) 和全因死亡率：配对后，GLP-1 RA加SGLT2i组的平均年龄为（57.1 ± 10.8）岁，仅使用SGLT2i组的平均年龄为（57.2 ± 11.7）岁。与单纯 SGLT2i- 组相比，GLP-1 RA 加 SGLT2i- 组发生 MAKE（危险比 [HR]：0.73，95% 置信区间 [CI]：0.69-0.77）、AKI（HR：0.82，95% C0I：0.77-0.87）、ESKD（HR：0.61，95% CI：0.47-0.78）和全因死亡（HR：0.54，95% CI：0.50-0.58）的风险显著降低。此外，亚组分析显示，不同亚组的获益情况一致：结论：GLP-1 RA 和 SGLT2i 的双重疗法有助于改善肾脏预后，解决糖尿病肾病日益加重的负担。

{"title":"Enhanced renoprotective effects of combined glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: Real-world evidence","authors":"Jian-Yu Jhu, Yu-Wei Fang, Chung-Yen Huang, Hung-Hsiang Liou, Mon-Ting Chen, Ming-Hsien Tsai","doi":"10.1111/jdi.14361","DOIUrl":"10.1111/jdi.14361","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Developing a more effective treatment for the global impact of diabetic kidney disease is crucial. This study examined the renoprotective effects of combining glucagon-like peptide-1 receptor agonists (GLP-1 RA) with sodium–glucose cotransporter 2 inhibitors (SGLT2i) compared to SGLT2is alone in type 2 diabetes (DM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective cohort study used data from the TriNetX Global Collaborative Network. Type 2 DM patients with estimated glomerular filtration rates ≥60 mL/min/1.73 m<sup>2</sup> who used GLP-1 RA or SGLT2i between January 1, 2013, and December 31, 2023. Propensity score matching balanced baseline characteristics, resulting in 71,186 patients in each group (combined GLP-1 RA and SGLT2i therapy vs SGLT2i alone). Cox regression model was adopted to compare outcomes over a 5-year period, including major adverse kidney events (MAKE), acute kidney injury (AKI), end-stage kidney disease (ESKD), and all-cause mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After matching, the average age was 57.1 ± 10.8 years for the GLP-1 RA plus SGLT2i group and 57.2 ± 11.7 years for the SGLT2i-only group. The GLP-1 RA plus SGLT2i group had significantly lower risk of MAKE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.69–0.77), AKI (HR: 0.82, 95% C0I: 0.77–0.87), ESKD (HR: 0.61, 95% CI: 0.47–0.78), and all-cause mortality (HR: 0.54, 95% CI: 0.50–0.58) compared to the SGLT2i-only group. Moreover, subgroup analyses showed consistent benefits across different subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dual therapy with GLP-1 RA and SGLT2i is supported to enhance renal outcomes and address the growing burden of diabetic kidney disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"204-214"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOSL2 activates TGF-β1-mediated GLUT1/mTOR signaling to promote diabetic kidney disease FOSL2 可激活 TGF-β1 介导的 GLUT1/mTOR 信号，从而促进糖尿病肾病的发生。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-21 DOI: 10.1111/jdi.14360

Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

Aims/Introduction

Diabetic kidney disease (DKD) is a major cause of kidney failure. FOS-like antigen 2 (FOSL2) has been revealed to be increased in kidney biopsies of patients with lupus nephritis, while its association with DKD remains unsolved. This study aimed to characterize the role of FOSL2 in DKD and its mechanism.

Method

The kidney tissues of DKD mice induced by STZ and a high-fat diet were subjected to PAS and Masson's staining. Glomerular mesangial cells (MCs) were treated with high glucose (HG) or normal glucose (NG). CCK-8 and EdU assays were performed to detect cell proliferation, and immunoblotting was conducted to analyze ECM deposition. ChIP-qPCR was performed on MCs to detect the binding of FOSL2 on the TGF-β1 promoter and a dual-luciferase assay to detect the impact of FOSL2 on the transcription of the TGF-β1 promoter.

Results

FOSL2 was elevated in the kidney tissues of DKD mice. Knockdown of FOSL2 reduced the mRNA expression of TGF-β1 to decrease the protein expression of GLUT1 and mTOR in the kidney tissues of DKD mice, and TGF-β1 reversed the effects caused by knockdown of FOSL2. The mTOR inhibitor Rapamycin alleviated kidney injury in the presence of FOSL2. Knockdown of FOSL2 inhibited the proliferation and improved ECM deposition of MCs, which were reversed by TGF-β1. Rapamycin and GLUT1 inhibitor BAY-876 reversed the promotion effect of FOSL2 on the proliferation of NG-MCs/HG-MCs and improved ECM deposition of MCs.

Conclusions

Our data demonstrated that FOSL2 accentuates DKD in mice by increasing TGF-β1-induced GLUT1/mTOR signaling.

目的/简介：糖尿病肾病（DKD）是导致肾衰竭的主要原因。研究发现，狼疮性肾炎患者肾活检组织中的 FOS 样抗原 2（FOSL2）含量升高，但其与 DKD 的关系仍未解决。本研究旨在阐明FOSL2在DKD中的作用及其机制：方法：对 STZ 和高脂饮食诱导的 DKD 小鼠肾组织进行 PAS 和 Masson 染色。肾小球系膜细胞（MCs）经高葡萄糖（HG）或正常葡萄糖（NG）处理。用 CCK-8 和 EdU 检测细胞增殖，用免疫印迹分析 ECM 沉积。对 MCs 进行 ChIP-qPCR 检测 FOSL2 与 TGF-β1 启动子的结合情况，并用双荧光素酶检测 FOSL2 对 TGF-β1 启动子转录的影响：结果：FOSL2在DKD小鼠肾脏组织中升高。结果：FOSL2在DKD小鼠肾脏组织中升高，敲除FOSL2可降低TGF-β1的mRNA表达，从而降低DKD小鼠肾脏组织中GLUT1和mTOR的蛋白表达。mTOR抑制剂雷帕霉素能减轻FOSL2存在时的肾损伤。敲除 FOSL2 可抑制 MCs 的增殖并改善 ECM 的沉积，而 TGF-β1 可逆转这些影响。雷帕霉素和GLUT1抑制剂BAY-876逆转了FOSL2对NG-MCs/HG-MCs增殖的促进作用，并改善了MCs的ECM沉积：我们的数据表明，FOSL2 可通过增加 TGF-β1 诱导的 GLUT1/mTOR 信号转导来加重小鼠的 DKD。

{"title":"FOSL2 activates TGF-β1-mediated GLUT1/mTOR signaling to promote diabetic kidney disease","authors":"Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai","doi":"10.1111/jdi.14360","DOIUrl":"10.1111/jdi.14360","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Diabetic kidney disease (DKD) is a major cause of kidney failure. FOS-like antigen 2 (FOSL2) has been revealed to be increased in kidney biopsies of patients with lupus nephritis, while its association with DKD remains unsolved. This study aimed to characterize the role of FOSL2 in DKD and its mechanism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The kidney tissues of DKD mice induced by STZ and a high-fat diet were subjected to PAS and Masson's staining. Glomerular mesangial cells (MCs) were treated with high glucose (HG) or normal glucose (NG). CCK-8 and EdU assays were performed to detect cell proliferation, and immunoblotting was conducted to analyze ECM deposition. ChIP-qPCR was performed on MCs to detect the binding of FOSL2 on the TGF-β1 promoter and a dual-luciferase assay to detect the impact of FOSL2 on the transcription of the TGF-β1 promoter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FOSL2 was elevated in the kidney tissues of DKD mice. Knockdown of FOSL2 reduced the mRNA expression of TGF-β1 to decrease the protein expression of GLUT1 and mTOR in the kidney tissues of DKD mice, and TGF-β1 reversed the effects caused by knockdown of FOSL2. The mTOR inhibitor Rapamycin alleviated kidney injury in the presence of FOSL2. Knockdown of FOSL2 inhibited the proliferation and improved ECM deposition of MCs, which were reversed by TGF-β1. Rapamycin and GLUT1 inhibitor BAY-876 reversed the promotion effect of FOSL2 on the proliferation of NG-MCs/HG-MCs and improved ECM deposition of MCs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data demonstrated that FOSL2 accentuates DKD in mice by increasing TGF-β1-induced GLUT1/mTOR signaling.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"187-203"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding 产褥期纯母乳喂养对妊娠糖尿病妇女血脂特征的影响。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-20 DOI: 10.1111/jdi.14349

Jin He, Xiaoxiao Yin, Tingting Yu, Lu Li, Yan Cui, Chen Jiang, Chengping Qiao, Zhijing Miao, Xianwei Cui, Chenbo Ji

Objective

We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding.

Methods

Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed. The relationship between underlying lipidomic responses and lactation was explored.

Results

Improved glucose homeostasis and insulin sensitivity were observed in GDM women who adopted breastfeeding during the puerperium. Further lipidomics analysis revealed prominent correlations between lipid constitution changes and breastfeeding in women with GDM. A total of 766 lipid species were identified, 33 of which were found to be significantly altered in response to lactation. Significant associations between dysregulated lipids and maternal metabolic parameters were also shown. Subsequently, we identified a panel of three lipids that were strongly associated with breastfeeding, from which we constructed a predictive model with higher discriminating power.

Conclusions

We generally revealed that lactation during puerperium appears to have favorable effects on diabetogenic risk factors for GDM women. We also discovered that lipidomic changes related to lactation could elucidate the mother's recovery from GDM pregnancy.

目的我们在此研究产褥期哺乳是否有助于逆转妊娠的致糖尿病效应，并进一步探讨母乳喂养时血脂谱的变化：方法：我们招募了 35 名确诊为 GDM 的产妇，并在产后约 6 周时采集了空腹血浆样本。测定了产妇的代谢参数，并进行了非靶向脂质体分析。研究人员探讨了基本脂质体反应与泌乳之间的关系：结果：在产褥期采用母乳喂养的 GDM 妇女中观察到葡萄糖稳态和胰岛素敏感性得到改善。进一步的脂质组学分析表明，GDM 妇女的脂质构成变化与母乳喂养之间存在显著的相关性。共鉴定出 766 种脂质，其中 33 种脂质在哺乳期发生了显著变化。脂质失调与母体代谢参数之间也存在显著关联。随后，我们确定了与母乳喂养密切相关的三种脂质，并据此构建了一个具有较高辨别力的预测模型：结论：我们普遍发现，产褥期哺乳似乎对 GDM 妇女的致糖尿病风险因素有有利影响。我们还发现，与哺乳期有关的脂质体变化可以阐明母亲从 GDM 妊娠中恢复的情况。

{"title":"Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding","authors":"Jin He, Xiaoxiao Yin, Tingting Yu, Lu Li, Yan Cui, Chen Jiang, Chengping Qiao, Zhijing Miao, Xianwei Cui, Chenbo Ji","doi":"10.1111/jdi.14349","DOIUrl":"10.1111/jdi.14349","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed. The relationship between underlying lipidomic responses and lactation was explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Improved glucose homeostasis and insulin sensitivity were observed in GDM women who adopted breastfeeding during the puerperium. Further lipidomics analysis revealed prominent correlations between lipid constitution changes and breastfeeding in women with GDM. A total of 766 lipid species were identified, 33 of which were found to be significantly altered in response to lactation. Significant associations between dysregulated lipids and maternal metabolic parameters were also shown. Subsequently, we identified a panel of three lipids that were strongly associated with breastfeeding, from which we constructed a predictive model with higher discriminating power.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We generally revealed that lactation during puerperium appears to have favorable effects on diabetogenic risk factors for GDM women. We also discovered that lipidomic changes related to lactation could elucidate the mother's recovery from GDM pregnancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"315-325"},"PeriodicalIF":3.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is glucose-induced hypersecretion of glicentin after the revision surgery using Roux-en-Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? 在腹腔镜袖带胃切除术后糖尿病未缓解的 2 型糖尿病患者中，使用 Roux-en-Y 胃旁路术进行翻修手术后，葡萄糖诱导的格列真因高分泌与胰岛素高分泌导致的血糖控制改善有关吗？

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-18 DOI: 10.1111/jdi.14325

Yukako Yamamoto, Osamu Sekine, Jun Ito-Kobayashi, Ayane Nishida, Takeshi Togawa, Yuki Ozamoto, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwagi

We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux-en-Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post-LSG. Although a marked increase in glucose-induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion.

我们报告了一名病态肥胖的 2 型糖尿病（T2DM）患者的病例详情，该患者在接受腹腔镜袖带胃切除术（LSG）后，糖尿病缓解失败。在使用 Roux-en-Y 胃旁路术（RYGB）进行翻修手术后，他的高血糖症状得到了明显改善，胃角部分无法摄入固体食物的情况在翻修手术后也消失了。有趣的是，与 LSG 术后相比，RYGB 术后口服葡萄糖耐量试验 OGTT 显示胰岛素分泌有所改善，胃泌素分泌明显增加，而胰高血糖素相关肽 1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）分泌变化不大。虽然 RYGB 术后葡萄糖诱导的格列真特分泌明显增加，胰岛素分泌也随之增加，但 RYGB 术后格列真特分泌增加是否与刺激胰岛素分泌有关，还需要进一步研究证实。

{"title":"Is glucose-induced hypersecretion of glicentin after the revision surgery using Roux-en-Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy?","authors":"Yukako Yamamoto, Osamu Sekine, Jun Ito-Kobayashi, Ayane Nishida, Takeshi Togawa, Yuki Ozamoto, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwagi","doi":"10.1111/jdi.14325","DOIUrl":"10.1111/jdi.14325","url":null,"abstract":"<p>We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux-en-Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post-LSG. Although a marked increase in glucose-induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion.</p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"343-347"},"PeriodicalIF":3.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender-specific genetic influence of rs1111875 on diabetes risk: Insights from the Taiwan biobank study rs1111875对糖尿病风险的性别遗传影响：台湾生物库研究的启示。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-18 DOI: 10.1111/jdi.14359

Chih-Wei Chiang, Ying-Hsiang Chou, Chien-Ning Huang, Wen-Yu Lu, Yung-Po Liaw

Background

This study investigates the gender-specific genetic influence of the single nucleotide polymorphism (SNP) rs1111875 on diabetes risk within the Taiwanese population using data from the Taiwan Biobank. Diabetes mellitus, particularly type 2 diabetes (T2D), is influenced by genetic factors, and the rs1111875 SNP near the hematopoietically expressed homeobox (HHEX) gene has been linked to T2D susceptibility.

Methods

The study included 69,272 participants after excluding those from arsenic-polluted areas and those with incomplete data. Logistic regression models were used for analyses.

Results

The analyses revealed that the CT genotype of rs1111875 was associated with an increased risk of diabetes (OR = 1.092, 95% CI = 1.030–1.157, P = 0.003), as was the TT genotype (OR = 1.280, 95% CI = 1.165–1.407, P < 0.001). The effect was more pronounced in women (CT: OR = 1.118, 95% CI = 1.036–1.207, P = 0.004; TT: OR = 1.404, 95% CI = 1.243–1.585, P < 0.001). Men exhibited a higher overall risk of diabetes (OR = 1.565, 95% CI = 1.445–1.694, P < 0.001) and had a higher prevalence (12.71% vs 7.80%, P < 0.001) compared to women.

Conclusions

The findings underscore the importance of considering gender differences in genetic studies of diabetes and suggest that personalized diabetes management strategies should account for both genetic and gender-specific risk factors. This research contributes to the broader understanding of genetic determinants of diabetes and their interaction with gender, aiming to enhance personalized healthcare strategies for diabetes prevention and treatment.

研究背景本研究利用台湾生物库的数据，调查了单核苷酸多态性（SNP）rs1111875对台湾人群糖尿病风险的性别特异性遗传影响。糖尿病，尤其是 2 型糖尿病（T2D）受遗传因素的影响，而造血表达同源染色体（HHEX）基因附近的 rs1111875 SNP 与 T2D 易感性有关：研究纳入了 69 272 名参与者，但排除了来自砷污染地区和数据不完整的参与者。采用逻辑回归模型进行分析：分析结果表明，rs1111875 的 CT 基因型与糖尿病风险增加有关（OR = 1.092，95% CI = 1.030-1.157，P = 0.003），TT 基因型也与糖尿病风险增加有关（OR = 1.280，95% CI = 1.165-1.407，P 结论：rs1111875 的 CT 基因型与糖尿病风险增加有关（OR = 1.092，95% CI = 1.030-1.157，P = 0.003）：研究结果强调了在糖尿病遗传研究中考虑性别差异的重要性，并建议个性化糖尿病管理策略应考虑遗传和性别特异性风险因素。这项研究有助于人们更广泛地了解糖尿病的遗传决定因素及其与性别的相互作用，从而加强糖尿病预防和治疗的个性化医疗策略。

{"title":"Gender-specific genetic influence of rs1111875 on diabetes risk: Insights from the Taiwan biobank study","authors":"Chih-Wei Chiang, Ying-Hsiang Chou, Chien-Ning Huang, Wen-Yu Lu, Yung-Po Liaw","doi":"10.1111/jdi.14359","DOIUrl":"10.1111/jdi.14359","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study investigates the gender-specific genetic influence of the single nucleotide polymorphism (SNP) rs1111875 on diabetes risk within the Taiwanese population using data from the Taiwan Biobank. Diabetes mellitus, particularly type 2 diabetes (T2D), is influenced by genetic factors, and the rs1111875 SNP near the hematopoietically expressed homeobox (HHEX) gene has been linked to T2D susceptibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 69,272 participants after excluding those from arsenic-polluted areas and those with incomplete data. Logistic regression models were used for analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analyses revealed that the CT genotype of rs1111875 was associated with an increased risk of diabetes (OR = 1.092, 95% CI = 1.030–1.157, <i>P</i> = 0.003), as was the TT genotype (OR = 1.280, 95% CI = 1.165–1.407, <i>P</i> < 0.001). The effect was more pronounced in women (CT: OR = 1.118, 95% CI = 1.036–1.207, <i>P</i> = 0.004; TT: OR = 1.404, 95% CI = 1.243–1.585, <i>P</i> < 0.001). Men exhibited a higher overall risk of diabetes (OR = 1.565, 95% CI = 1.445–1.694, <i>P</i> < 0.001) and had a higher prevalence (12.71% vs 7.80%, <i>P</i> < 0.001) compared to women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings underscore the importance of considering gender differences in genetic studies of diabetes and suggest that personalized diabetes management strategies should account for both genetic and gender-specific risk factors. This research contributes to the broader understanding of genetic determinants of diabetes and their interaction with gender, aiming to enhance personalized healthcare strategies for diabetes prevention and treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 1","pages":"36-42"},"PeriodicalIF":3.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional association of irregular dietary habits with glycemic control and body mass index among people with diabetes 不规律饮食习惯与糖尿病患者血糖控制和体重指数的横断面关联。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-17 DOI: 10.1111/jdi.14347

Mika Shimizu, Junko Oya, Yuichiro Kondo, Aki Katamine, Yukiko Hasegawa, Tomoko Nakagami

Aims/Introduction

To determine the association of irregular dietary habits with HbA1c and body mass index (BMI) in people with diabetes.

Materials and Methods

We included 4,421 people with diabetes aged 20–74 years (type 1 diabetes (T1D), 19.1%) who answered a questionnaire at mealtime. Adjusted least square means in HbA1c and BMI in patients with irregular dietary habits: “irregular mealtimes (irregular),” “skipping breakfast (SB),” and “late dinner (LD)” were compared to those with “regular dietary habits (regular).” Multivariable logistic regression analyses were performed to examine the association of irregular dietary habits with HbA1c ≥ 7% and BMI ≥25 kg/m².

Results

HbA1c was significantly higher for “irregular” in both sexes and for “LD” in women than those of “regular” in people with T1D. HbA1c was significantly higher for “LD,” and BMI was higher for almost all irregular dietary habits than those of “regular” in people with type 2 diabetes (T2D). Odds ratios (ORs) for HbA1c ≥7% were 3.20 (95% confidence interval (CI), 1.30–7.89) for T1D women with “irregular” and 1.73 (1.20–2.49) and 2.20 (1.14–3.65) for T2D men and women with “LD,” respectively. ORs for BMI ≥25 kg/m² were 1.60 (95% CI, 1.15–2.22) for T2D men with “irregular” and 1.43 (1.02–2.01) and 2.11 (1.21–3.65) for T2D women and men with “LD,” respectively.

Conclusions

Irregular mealtimes are associated with poor glycemic control in T1D women and are associated with obesity in T2D men. Furthermore, a late dinner was associated with high HbA1c levels and BMI in people with T2D.

目的/简介：确定糖尿病患者不规律的饮食习惯与 HbA1c 和体重指数（BMI）之间的关系：我们纳入了 4,421 名 20-74 岁的糖尿病患者（1 型糖尿病 (T1D)，19.1%），他们在进餐时回答了问卷。饮食习惯不规律患者的 HbA1c 和 BMI 调整后最小平方均值：将 "进餐时间不规律（不规律）"、"不吃早餐（SB）"和 "晚餐吃得晚（LD）"的患者与 "饮食习惯规律（规律）"的患者进行比较。对不规律饮食习惯与 HbA1c ≥ 7% 和 BMI ≥ 25 kg/m2 的关系进行了多变量逻辑回归分析：结果：在T1D患者中，"不规律 "饮食习惯的男女患者和 "低密度 "饮食习惯的女性患者的HbA1c均明显高于 "规律 "饮食习惯的患者。在 2 型糖尿病（T2D）患者中，"低密度 "饮食习惯的 HbA1c 明显高于 "正常 "饮食习惯的 HbA1c，几乎所有不规律饮食习惯的 BMI 都高于 "正常 "饮食习惯的 BMI。有 "不规律 "饮食习惯的 T1D 女性患者 HbA1c ≥7% 的比值比 (OR) 为 3.20（95% 置信区间 (CI)，1.30-7.89）；有 "低密度 "饮食习惯的 T2D 男性和女性患者 HbA1c ≥7% 的比值比 (OR) 分别为 1.73（1.20-2.49）和 2.20（1.14-3.65）。体重指数≥25 kg/m2的OR值在 "不规律 "的T2D男性中为1.60（95% CI，1.15-2.22），在 "低密度 "的T2D女性和男性中分别为1.43（1.02-2.01）和2.11（1.21-3.65）：结论：进餐时间不规律与 T1D 女性血糖控制不佳有关，与 T2D 男性肥胖有关。此外，晚饭吃得晚与 T2D 患者的高 HbA1c 水平和体重指数有关。

{"title":"Cross-sectional association of irregular dietary habits with glycemic control and body mass index among people with diabetes","authors":"Mika Shimizu, Junko Oya, Yuichiro Kondo, Aki Katamine, Yukiko Hasegawa, Tomoko Nakagami","doi":"10.1111/jdi.14347","DOIUrl":"10.1111/jdi.14347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>To determine the association of irregular dietary habits with HbA1c and body mass index (BMI) in people with diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We included 4,421 people with diabetes aged 20–74 years (type 1 diabetes (T1D), 19.1%) who answered a questionnaire at mealtime. Adjusted least square means in HbA1c and BMI in patients with irregular dietary habits: “irregular mealtimes (irregular),” “skipping breakfast (SB),” and “late dinner (LD)” were compared to those with “regular dietary habits (regular).” Multivariable logistic regression analyses were performed to examine the association of irregular dietary habits with HbA1c ≥ 7% and BMI ≥25 kg/m<sup>2</sup>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HbA1c was significantly higher for “irregular” in both sexes and for “LD” in women than those of “regular” in people with T1D. HbA1c was significantly higher for “LD,” and BMI was higher for almost all irregular dietary habits than those of “regular” in people with type 2 diabetes (T2D). Odds ratios (ORs) for HbA1c ≥7% were 3.20 (95% confidence interval (CI), 1.30–7.89) for T1D women with “irregular” and 1.73 (1.20–2.49) and 2.20 (1.14–3.65) for T2D men and women with “LD,” respectively. ORs for BMI ≥25 kg/m<sup>2</sup> were 1.60 (95% CI, 1.15–2.22) for T2D men with “irregular” and 1.43 (1.02–2.01) and 2.11 (1.21–3.65) for T2D women and men with “LD,” respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Irregular mealtimes are associated with poor glycemic control in T1D women and are associated with obesity in T2D men. Furthermore, a late dinner was associated with high HbA1c levels and BMI in people with T2D.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"285-291"},"PeriodicalIF":3.1,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain 伴有糖尿病周围神经痛的 2 型糖尿病患者的血液代谢组学特征。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation

Pub Date : 2024-11-16 DOI: 10.1111/jdi.14355

Hung-Chou Kuo, Chia-Ni Lin, Sung-Sheng Tsai, Chiung-Mei Chen, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Yi-Ching Weng, Jawl-Shan Hwang

Aims

This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM).

Materials and Methods

Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites.

Results

Sixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low-density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered.

Interpretation

Blood metabolites include glutamate, and phospholipid-related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP.

目的：本研究旨在确定 2 型糖尿病（T2DM）患者糖尿病周围神经病理性疼痛（DPNP）的代谢标记物：采用液相色谱串联质谱法分析了非糖尿病对照组（n = 27）、无 DPNP 的 T2DM（n = 58）和有 DPNP 的 T2DM（n = 29）的血液中氨基酸、生物胺、鞘磷脂、磷脂酰胆碱（PC）、肉毒碱和己糖类代谢物水平。通过偏最小二乘判别分析对临床参数和代谢物进行了变量重要性预测（VIP）评估：结果：有 16 个变量的 VIP 值大于 1.0（P 解释性）：血液代谢物包括谷氨酸和磷脂相关代谢物，这些代谢物与神经病理性疼痛有关，有可能成为 DPNP 的生物标记物。要了解这些代谢物变化在 DPNP 中的作用机制，还需要进一步的研究。

{"title":"Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain","authors":"Hung-Chou Kuo, Chia-Ni Lin, Sung-Sheng Tsai, Chiung-Mei Chen, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Yi-Ching Weng, Jawl-Shan Hwang","doi":"10.1111/jdi.14355","DOIUrl":"10.1111/jdi.14355","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (<i>n</i> = 27), T2DM without DPNP (<i>n</i> = 58), and T2DM with DPNP (<i>n</i> = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen variables with VIP > 1.0 (<i>P</i> < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low-density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>Blood metabolites include glutamate, and phospholipid-related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 2","pages":"246-256"},"PeriodicalIF":3.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0