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Infections in long-term care: Challenges in an ageing Europe 长期护理中的感染:老龄化欧洲的挑战
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-11-08 DOI: 10.1016/j.iccn.2025.104271
Jordi Rello , Niccolò Buetti , Hagar L. Mowafy

Background

The demographic shift towards an ageing population, especially in Europe, place a significant burden on healthcare systems and increasing demand for long-term care facility (LTCF) services. These facilities provide support to both older individuals and patients with disabilities. Despite their importance, LTCFs continue to face challenges in infection prevention and control (IPC) contributing to increase the burden of healthcare-associated infections (HAIs) and antimicrobial resistance (AMR).

Objective

The aim of this opinion review is to summarize current global and regional IPC guidance applicable to LTCFs and identifies critical gaps that must be addressed to improve residents’ safety.

Discussion

Global and regional organizations including the World Health Organization (WHO), European Centre for Disease Prevention and Control (ECDC), United States Centre for Disease Control and Prevention (CDC), and other professional organizations provides basic IPC recommendations mostly adapted from acute healthcare settings. Despite these valuable resources, major gaps persist, especially within the European context. One of the major gaps is that most of these IPC guidance are adapted from acute care settings without taking into consideration the unique structural and social differences of LTCFs. The inherent heterogeneity of LTCFs within European countries, the scarcity of high-quality studies assessing different IPC interventions across diverse LTCF types, compounded by the limitations in workforce capacity and surveillance gaps further pose critical challenges to effective IPC guidance.

Implications for Clinical Practice

Unified, evidence-based guidelines specifically designed for LTCFs are urgently needed to warrant the safety and equity of service provided to LTCF residents across different countries and sectors. Such a framework must emphasize continuous surveillance, workforce development, and practical, applicable strategies that can be easily incorporated into the unique nature of LTCFs.
人口结构向老龄化的转变,特别是在欧洲,给医疗保健系统带来了沉重的负担,并增加了对长期护理设施(LTCF)服务的需求。这些设施为老年人和残疾患者提供支持。尽管它们很重要,但ltcf在感染预防和控制(IPC)方面继续面临挑战,从而增加了卫生保健相关感染(HAIs)和抗菌素耐药性(AMR)的负担。本意见审查的目的是总结当前适用于ltcf的全球和区域IPC指南,并确定必须解决的关键差距,以提高居民的安全。讨论包括世界卫生组织(世卫组织)、欧洲疾病预防和控制中心(ECDC)、美国疾病控制和预防中心(CDC)在内的全球和区域组织以及其他专业组织提供了基本的IPC建议,这些建议大多改编自紧急医疗保健环境。尽管有这些宝贵的资源,但主要的差距仍然存在,特别是在欧洲范围内。其中一个主要差距是,这些IPC指南大多改编自急性护理环境,而没有考虑到长期护理中心独特的结构和社会差异。欧洲国家LTCF的内在异质性,评估不同LTCF类型的不同IPC干预措施的高质量研究的缺乏,再加上劳动力能力的限制和监测差距,进一步对有效的IPC指导构成了严峻的挑战。临床实践的意义迫切需要专门为LTCF设计的统一的循证指南,以保证向不同国家和部门的LTCF居民提供的服务的安全性和公平性。这样的框架必须强调持续的监督、劳动力的发展和实际的、适用的战略,这些战略可以很容易地融入到ltcf的独特性质中。
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引用次数: 0
Simulation and validation: re-evaluating gastric tube-tip manometry for nasogastric tube verification – Response to Tao Zhang 模拟与验证:重新评估胃管尖端测压法在鼻胃管验证中的应用——对张涛的回应。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-27 DOI: 10.1016/j.iccn.2025.104130
Yunxia Chen, Zhiyuan Sheng
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引用次数: 0
Language, culture and communication vulnerability – Letter on Istanboulian et al. 语言、文化和沟通脆弱性——伊斯坦布尔等人的信。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-27 DOI: 10.1016/j.iccn.2025.104270
Melissa J Bloomer , Krishnaswamy Sundararajan
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引用次数: 0
Observational research in critical care: Harnessing the lens of truth 重症监护的观察研究:利用真相的透镜。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-27 DOI: 10.1016/j.iccn.2025.104259
Karin Plummer , Ann Bonner , Melissa J Bloomer
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引用次数: 0
Endotracheal tube cuff modifications for VAP prevention: Bridging evidence and clinical practice – Letter on Li S et al. 气管内套管袖带改良预防VAP:连接证据与临床实践- Li S等人评论。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-27 DOI: 10.1016/j.iccn.2025.104269
Rongyi Xu, Deyi Pan, Lisong Chen
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引用次数: 0
Omega-3 fatty acids in critical care nutrition: Balancing promise and pragmatism Omega-3脂肪酸在重症监护营养:平衡承诺和实用主义。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-27 DOI: 10.1016/j.iccn.2025.104264
Antonios Katsounas , Georgios Papathanakos , Despoina Koulenti
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引用次数: 0
Effect of ultrashort-acting β-blocker on the mortality of patients with sepsis or septic shock: A systematic review and trial sequential meta-analysis of randomized controlled trials 超短效β受体阻滞剂对脓毒症或脓毒性休克患者死亡率的影响:随机对照试验的系统回顾和试验序贯荟萃分析。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-26 DOI: 10.1016/j.iccn.2025.104265
Po-Yu Huang , Ting-Hui Liu , Jheng-Yan Wu , Ya-Wen Tsai , Wan-Hsuan Hsu , Min-Hsiang Chuang , Hung-Jen Tang , Chih-Cheng Lai

Background

Adrenergic responses, particularly tachycardia, play a role in sepsis-related complications. Ultrashort-acting β-blockers have been evaluated in randomized controlled trials (RCTs) for their impact on sepsis outcomes, but conflicting results have been reported. This systematic review and meta-analysis aim to provide an updated perspective on the impact of ultrashort-acting β-blockers on the clinical outcomes of sepsis.

Methods

A comprehensive search of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and ClinicalTrials.gov was conducted from inception to January 12, 2024. RCTs investigating the clinical effects and safety of ultrashort-acting β-blockers in sepsis or septic shock were included. Meta-analyses were performed using random-effects models, and trial sequential analysis (TSA) was conducted to evaluate the reliability of cumulative evidence. The primary outcome was 28-day mortality rate.

Results

A total of 2253 patients involved in 27 RCTs were included. Ultrashort-acting β-blockers significantly reduced the 28-day mortality rate (31.6% versus 48.4%; risk ratio [RR] 0.66; 95% CI 0.56–0.78). TSA provided robust evidence for the 28-day and in-hospital mortality benefit. The survival benefit remains evident in subgroups of patients with septic tachycardia (RR, 0.66; 95% CI, 0.47–0.93), septic cardiomyopathy (RR, 0.61; 95% CI, 0.44–0.83), Chinese populations (RR, 0.64; 95% CI, 0.54–0.76), and those treated with esmolol (RR, 0.64; 95% CI, 0.56–0.73). For patients with septic shock, only those with tachycardia demonstrated a statistically significant difference in mortality rates (RR, 0.70; 95% CI, 0.55–0.88).

Conclusions

Adjuvant ultrashort-acting β-blocker therapy demonstrated potential benefits in improving survival for patients with sepsis or septic shock.

Implications for clinical practice

This study highlights the potential benefits of adjuvant ultrashort-acting β-blocker therapy for the treatment of sepsis or septic shock in terms of enhanced survival and other clinical advantages, including reduced heart rate and cardiovascular biomarkers. Furthermore, such therapy did not appear to impair cardiac function and hemodynamic stability.
背景:肾上腺素能反应,特别是心动过速,在脓毒症相关并发症中起作用。超短效β受体阻滞剂在随机对照试验(rct)中被评估对败血症结果的影响,但报道了相互矛盾的结果。本系统综述和荟萃分析旨在为超短效β受体阻滞剂对败血症临床结局的影响提供最新视角。方法:综合检索PubMed、Embase、Cochrane图书馆、中国国家知识基础设施和ClinicalTrials.gov网站,检索时间自成立至2024年1月12日。研究超短效β受体阻滞剂在脓毒症或感染性休克中的临床效果和安全性的随机对照试验。采用随机效应模型进行meta分析,并采用试验序列分析(TSA)评估累积证据的可靠性。主要终点为28天死亡率。结果:27项rct共纳入2253例患者。超短效β受体阻滞剂显著降低28天死亡率(31.6% vs 48.4%;风险比[RR] 0.66; 95% CI 0.56-0.78)。TSA为28天和住院死亡率的降低提供了强有力的证据。在脓毒性心动过速(RR, 0.66; 95% CI, 0.47-0.93)、脓毒性心肌病(RR, 0.61; 95% CI, 0.44-0.83)、中国人群(RR, 0.64; 95% CI, 0.54-0.76)和接受艾司洛尔治疗的患者(RR, 0.64; 95% CI, 0.56-0.73)的亚组中,生存获益仍然明显。对于感染性休克患者,只有心动过速患者的死亡率有统计学差异(RR, 0.70; 95% CI, 0.55-0.88)。结论:辅助超短效β受体阻滞剂治疗在提高脓毒症或感染性休克患者的生存率方面具有潜在的益处。临床实践意义:本研究强调了辅助超短效β受体阻滞剂治疗败血症或感染性休克的潜在益处,包括提高生存率和其他临床优势,包括降低心率和心血管生物标志物。此外,这种治疗似乎不会损害心功能和血流动力学稳定性。
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引用次数: 0
The restraint-free ICU: not quite there yet 无需束缚的重症监护室:还没到那一步。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-26 DOI: 10.1016/j.iccn.2025.104261
Tommaso Rosà, Gaia Tempo, Massimo Antonelli
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引用次数: 0
Eye protection chamber versus adhesive tape to prevent corneal injury in critically ill patients: A randomized pilot-controlled trial 眼保护室与胶带预防危重患者角膜损伤:一项随机先导对照试验
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-26 DOI: 10.1016/j.iccn.2025.104263
Patricia Rezende do Prado , Natasha Varjão Volpáti , Waleska Olivares Nascimento , Fernanda Raphael Escobar Gimenes , Natália Pimentel Moreno Mantilla , Edna Lopes Monteiro , Thatiana Lameira Maciel Amaral , Jonas Bodini Alonso , Gustavo Trindade Valio

Objective

To evaluate the efficacy and feasibility of the eye protection chamber compared to adhesive tape in preventing corneal injury in critically ill adult patients.

Method

A two-arm, double-blind pilot randomized controlled trial following CONSORT guidelines. 80 critically ill patients were randomized into an intervention group (n = 40; eye drops plus eye protection chamber) and a control group (n = 40; eye drops plus micropore adhesive tape). Corneal health was assessed by a trained critical care nurse on days 1, 3, 5, 7, and 10 using fluorescein staining and portable slit-lamp examination. The primary outcome was the incidence of corneal injury. Secondary outcomes included the severity and associated risk factors.

Results

During the study period, 203 patients were assessed for eligibility. Of these, 123 (60.6 %) presented with corneal injury upon admission and were excluded, while 80 patients (39.4 %) met the inclusion criteria and were enrolled in the trial. In a randomized trial, corneal injury occurred in 11.2 % of participants, 7.5 % in the control group, and 3.75 % in the intervention group, indicating a 50 % reduction in risk with the chamber. Most injuries were classified as Grade 1. Grade 2 and bilateral injuries occurred only in the control group.

Conclusion

The eye protection chamber was effective and viable in reducing the incidence and severity of corneal injuries compared to adhesive tape.

Implications for clinical practice

The chamber demonstrated efficacy and feasibility in preventing corneal injuries in critically ill patients with impaired or absent blink reflexes, and it can be tested in other centers. Implementing preventive strategies, such as eyelid closure, lubrication, and mechanical protection, is essential to enhance patient safety and reduce avoidable ocular complications in intensive care settings.
目的:比较眼保护室与胶带预防成人危重患者角膜损伤的疗效和可行性。方法:一项遵循CONSORT指南的双盲随机对照试验。80例危重患者随机分为干预组(n = 40,滴眼液加护眼室)和对照组(n = 40,滴眼液加微孔胶带)。角膜健康由训练有素的重症护理护士在第1、3、5、7和10天使用荧光素染色和便携式裂隙灯检查进行评估。主要观察指标是角膜损伤的发生率。次要结局包括严重程度和相关危险因素。结果:在研究期间,203例患者被评估为合格。其中123例(60.6%)在入院时出现角膜损伤而被排除,而80例(39.4%)患者符合纳入标准并被纳入试验。在一项随机试验中,角膜损伤发生率为11.2%,对照组为7.5%,干预组为3.75%,表明使用腔室的风险降低了50%。大部分伤情为1级。2级和双侧损伤仅发生在对照组。结论:与胶布相比,护眼室能有效降低角膜损伤的发生率和严重程度。对临床实践的启示:该室在预防眨眼反射受损或缺失的危重患者角膜损伤方面已经证明了其有效性和可行性,并且可以在其他中心进行测试。实施闭眼、润滑和机械保护等预防策略对于加强患者安全并减少重症监护环境中可避免的眼部并发症至关重要。
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引用次数: 0
Important and feasible patient- and family-centered intensive care interventions: A Delphi study with stakeholders 重要和可行的以病人和家庭为中心的重症监护干预:与利益相关者的德尔菲研究。
IF 4.7 2区 医学 Q1 NURSING Pub Date : 2025-10-15 DOI: 10.1016/j.iccn.2025.104253
Bram Tilburgs , Carolien Bakker-Crommentuijn , Mirjam de Graaf , Mark van den Boogaard

Background

Intensive care unit (ICU) admissions can be stressful for patients and family members. Patients may face discomfort, pain, delirium, immobility, and uncertainty about recovery, while family members often experience emotional strain, uncertainty and fatigue. Patient- and family-centered care (PFCC) is a guideline recommended approach to reduce ICU-burden for both patient and family members. However, which interventions are important and feasible for PFCC in the ICU is unknown.

Objectives

To explore which PFCC interventions are most important and feasible in the ICU according to Dutch clinicians, patients and family members.

Methods

A 4-stage modified RAND/UCLA Appropriateness Method (RAM) Delphi study was conducted. First, a literature review and focus group interviews were used to identify important and feasible PFCC interventions. Second, ICU-stakeholders (nurses, physicians, patients and family members), rated interventions on importance and feasibility and added comments. Third, stakeholders discussed interventions rated as uncertain on importance and feasibility and created a second set of interventions. Fourth, stakeholders rated interventions from stage 3 on importance and feasibility and ranked interventions resulting in a top 5 of most important interventions.

Results

In total, 30 former patients and family members and 46 healthcare professionals participated. 35 interventions for PFCC in the ICU were identified. Of these, 31 were rated as both important and feasible, and four were rated as uncertain. The five highest-rated interventions focused on regular multidisciplinary conversations with patients and families about care and treatment plans, keeping a patient diary, offering psychological support from consultants, creating a tailored daily schedule, and ensuring consistent communication with the patient’s contact person.

Conclusion and implications for clinical Practice

Implementing interventions rated highly on both importance and feasibility may significantly enhance ICU care experiences for patients and families. The top five rated interventions indicate what was considered most important in minimizing the impact of an ICU admission.
背景:重症监护病房(ICU)入院对患者和家属来说可能是一种压力。患者可能面临不适、疼痛、谵妄、行动不便和不确定的康复,而家庭成员经常经历情绪紧张、不确定和疲劳。以患者和家庭为中心的护理(PFCC)是一种指南推荐的方法,以减轻患者和家庭成员的icu负担。然而,对于ICU的PFCC,哪些干预措施是重要和可行的尚不清楚。目的:探讨荷兰临床医生、患者及家属认为哪些PFCC干预措施在ICU中最重要、最可行。方法:采用改良RAND/UCLA适当性法(RAM)进行四阶段德尔菲研究。首先,通过文献回顾和焦点小组访谈来确定重要和可行的PFCC干预措施。其次,icu利益相关者(护士、医生、患者和家属)对干预措施的重要性和可行性进行了评级,并提出了意见。第三,利益相关者讨论了在重要性和可行性上被评为不确定的干预措施,并创建了第二套干预措施。第四,利益相关者根据重要性和可行性对第三阶段的干预措施进行评级,并对干预措施进行排名,从而得出最重要干预措施的前5名。结果:共有30名前患者及其家属和46名医护人员参与。在ICU中确定了35种PFCC的干预措施。其中,31项被评为重要和可行,4项被评为不确定。评分最高的五项干预措施集中在与患者和家属就护理和治疗计划进行定期的多学科对话,记录患者日记,提供咨询师的心理支持,制定量身定制的每日时间表,以及确保与患者联系人保持一致的沟通。结论和临床实践意义:实施高度重视和可行性的干预措施可以显著提高患者和家属的ICU护理体验。排名前五的干预措施表明,在最大限度地减少ICU入院的影响方面,最重要的是什么。
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引用次数: 0
期刊
Intensive and Critical Care Nursing
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