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Prevalence and risk factors of subsyndromal delirium in ICU: A systematic review and meta-analysis 重症监护病房亚临床谵妄的患病率和风险因素:系统回顾和荟萃分析
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103834

Objective

To systematically assess the prevalence and risk factors for subsyndromal delirium (SSD) in the intensive care unit.

Design

A systematic review and meta-analysis.

Methodology

This systematic review and meta-analysis was conducted in eight databases, including PubMed, Web of Science, Ovid, Scopus, China Knowledge Resource Integrated Database, Wanfang Database, Weipu Database and Chinese Biomedical Database. All original observational studies of subsyndromal delirium in the ICU were included, with languages limited to English and Chinese. The methodological quality was assessed by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality recommendation checklist. Meta-analysis was performed using Stata software (version 18.0).

Result

A total of 27 studies involving 7,286 participants were included in this review. The pooled prevalence of SSD was 32.4 % (95 %CI: 27.1 %-37.7 %). Fourteen studies reported 34 independent risk factors, and the following ten factors were significantly associated with SSD: older age, higher Acute Physiology and Chronic Health Evaluation II (APACHE II) score, lower Mini-mental Status Examination (MMSE) score, pain, mechanical ventilation, hypoproteinemia, blood transfusion, longer ICU stay, infection, and physical restraint.

Conclusion

We conducted a systematic review and meta-analysis to evaluate the prevalence of SSD in the ICU and identified 10 risk factors associated with SSD. However, the studies have significant heterogeneity, future research should be conducted in multicenter with large samples to strengthen the current evidence.

Implications for clinical practice

Subsyndromal delirium is a frequently occurring adverse event in the ICU, so it is recommended that clinicians and nurses incorporate the assessment of SSD into their daily routine. In this study, we also identified ten risk factors associated with SSD, and some of which could be modified or intervened. These findings provide a basis for ICU medical staff to identify patients at high risk of SSD and then implement individualized interventions to reduce the prevalence of SSD.

方法 本系统综述和荟萃分析在 PubMed、Web of Science、Ovid、Scopus、中国知识资源综合数据库、万方数据库、维普数据库和中国生物医学数据库等 8 个数据库中进行。所有关于重症监护病房亚临床谵妄的原始观察性研究均被纳入,语言限于英语和汉语。方法学质量采用纽卡斯尔-渥太华量表和美国医疗保健研究与质量机构推荐清单进行评估。本综述共纳入 27 项研究,涉及 7286 名参与者。汇总的 SSD 患病率为 32.4%(95%CI:27.1%-37.7%)。14项研究报告了34个独立的风险因素,以下10个因素与SSD显著相关:年龄较大、急性生理学和慢性健康评估II(APACHE II)评分较高、迷你精神状态检查(MMSE)评分较低、疼痛、机械通气、低蛋白血症、输血、ICU住院时间较长、感染和身体约束。对临床实践的启示亚综合征谵妄是 ICU 中经常发生的不良事件,因此建议临床医生和护士将 SSD 的评估纳入其日常工作中。在这项研究中,我们还发现了与 SSD 相关的十个风险因素,其中一些因素是可以改变或干预的。这些发现为重症监护病房的医务人员提供了一个依据,以便识别出高风险的 SSD 患者,然后实施个性化的干预措施来降低 SSD 的发生率。
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引用次数: 0
Prone position in the post COVID-19 era: Old lessons and new challenges for intensive care nurses
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103837
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引用次数: 0
Impact of new lighting technology versus traditional fluorescent bulbs on sedation and delirium in the ICU
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103833

Background

Critically ill patients frequently encounter disruptions in their circadian rhythms in the intensive care unit (ICU) environment. New lighting systems have been developed to enhance daytime light levels and to promote circadian alignment.

Objectives

To investigate the impact of implementing an innovative lighting technology that mimics natural light and reproduce the colour of the sky.

Design

Prospective, observational, non-randomized comparative trial. ICU patients were exposed to either a cutting-edge lighting system based on new technology (intervention group) or a conventional lighting system using fluorescent bulbs (control group).

Setting

An Italian intensive care unit with ten beds and five windowless rooms, thereby denying access to natural light. Three rooms had new lighting technology.

Main Outcome Measures

The two groups were compared to assess the prevalence or absence of delirium and the need for sedatives during ICU stay. The secondary aim was to assess the presence of anxiety, depression, and post-traumatic stress disorder in patients at 3, 6, and 12 months after ICU discharge.

Results

86 patients were included: 52 (60 %) in the intervention group and 34 (40 %) in the control group. Seventy-nine patients (82 %) were alive at ICU discharge. Fourteen patients (16 %) developed delirium (intervention group: n = 8 [15 %] vs. control group: n = 6 [18 %] in the control group, (P=0.781). The use of sedative drugs and neuromuscular blocking agents was similar in both the groups. No differences in the incidence of anxiety, depression, or post-traumatic stress disorders were observed among patients who underwent follow-up visits.

Conclusions

Compared to traditional fluorescent tube lighting, the innovative lighting system did not provide any significant benefit in reducing the frequency of delirium or the necessity for sedative medications.

Implications for Clinical Practice

A single intervention, the use of lights that mimic sunny light and the sky, did not result in a statistically significant reduction in the incidence of delirium. Delirium has a multifactorial aetiology, necessitating interventions that are multifaceted and address different domains.

背景重症患者在重症监护室(ICU)环境中经常会遇到昼夜节律紊乱的问题。目标研究采用模仿自然光和再现天空颜色的创新照明技术的影响。设计前瞻性、观察性、非随机比较试验。重症监护病房的患者被分配到基于新技术的先进照明系统(干预组)或使用荧光灯的传统照明系统(对照组)。主要结果测量两组患者在重症监护室住院期间的谵妄发生率和镇静剂需求量进行了比较。次要目的是评估患者在重症监护室出院后 3、6 和 12 个月时是否存在焦虑、抑郁和创伤后应激障碍:干预组 52 人(60%),对照组 34 人(40%)。79 名患者(82%)在重症监护室出院时仍然存活。14名患者(16%)出现谵妄(干预组:n = 8 [15 %] vs. 对照组:n = 6 [18 %],P=0.781)。两组患者使用镇静药物和神经肌肉阻滞剂的情况相似。结论与传统的荧光灯管照明相比,创新型照明系统在降低谵妄发生率或镇静药物使用必要性方面并无明显优势。谵妄的病因是多因素的,因此需要针对不同领域采取多方面的干预措施。
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引用次数: 0
The Perme ICU Physical Competency Assessment – Response to Javaid et al.
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103838
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引用次数: 0
Educational interventions reduce the severity of Post Intensive Care Syndrome-Family – Response to Rahimi-Bashar et al.
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103836
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引用次数: 0
Moving on from a “good death”: Child- and family-centred end-of-life care in paediatric critical care
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103832
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引用次数: 0
Practice and confidence in electrocardiogram interpretation among ICU nurses: A cross-sectional study
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-18 DOI: 10.1016/j.iccn.2024.103835

Objectives

This study aimed to determine practice and confidence in electrocardiogram (ECG) interpretation among intensive care unit (ICU) nurses in Fujian Province, China, and identify predictors of ECG interpretation practice.

Research methodology/design

A quantitative cross-sectional study was conducted between October 2021 and December 2021 among 357 respondents.

Setting

Conducted online at twenty-one hospitals in all nine cities of Fujian Province.

Main outcome measures

Purposive and convenient sampling techniques were employed in selecting hospitals and respondents, respectively. A validated and pre-tested Chinese version of the questionnaire was used in data collection. We conducted binary logistic regression to identify the predictors of ICU nurses’ ECG interpretation practice, and linear regression to analyze the relationship between ECG interpretation practice and confidence. We considered statistically significant a p-value < 0.05.

Results

The practice mean score of the respondents was 5.54 (SD = 2.26) out of 10 points, and only 2.2 % of nurses correctly interpreted all the patient ECG strips. Few ICU nurses (25.5 %) had good ECG interpretation practice, with a confidence mean score of 2.02 (SD = 0.99) out of 4 points in their overall ability to interpret patient ECG strips. Currently working unit in comparison to cardiac ICU (emergency ICU: AOR = 5.71, 95 % CI: 1.84–17.75); previous ECG training (AOR = 2.02, 95 % CI: 1.10–3.70); source of ECG training (university/school) (AOR = 2.02, 95 % CI: 1.12–3.65); and ECG knowledge (AOR = 16.18, 95 % CI: 7.43–35.25) were significantly associated with the ECG interpretation practice.

Conclusions

ICU nurses’ ECG interpretation practice in the current study was relatively poor. An ECG education program is recommended to impart ICU nurses with basic ECG knowledge for enhancing good ECG interpretation practice and confidence in nursing care provision.

Implications for clinical practice

Good ECG interpretation skills are paramount among ICU nurses for better patient outcomes. ECG knowledge among ICU nurses is an important predictor of effective ECG monitoring for cardiac arrhythmias. Therefore, frequent, continuouszgood practice and boost confidence in the provision of quality nursing care.

研究方法/设计2021年10月至2021年12月期间,对357名受访者进行了一项定量横断面研究。研究地点福建省9个地市的21家医院。在数据收集过程中,我们使用了经过验证和预先测试的中文版问卷。我们通过二元逻辑回归确定了 ICU 护士心电图解读实践的预测因素,并通过线性回归分析了心电图解读实践与信心之间的关系。结果受访者的实践平均分为 5.54(SD = 2.26)(满分 10 分),只有 2.2 % 的护士正确解读了所有患者的心电图条。少数 ICU 护士(25.5%)具有良好的心电图判读能力,其判读患者心电图条的总体能力的信心平均分为 2.02(SD = 0.99)分(满分 4 分)。与心脏重症监护室相比,目前工作单位(急诊重症监护室:AOR = 5.71,95 % CI:1.84-17.75);以前接受过心电图培训(AOR = 2.02,95 % CI:1.10-3.70);心电图培训来源(大学/学校)(AOR = 2.02,95 % CI:1.12-3.65);心电图知识(AOR = 16.18,95 % CI:7.43-35.25)与心电图解读实践显著相关。建议开展心电图教育计划,向 ICU 护士传授基本的心电图知识,以提高良好的心电图判读实践和护理信心。 对临床实践的意义良好的心电图判读技能对 ICU 护士来说至关重要,有助于改善患者预后。ICU 护士的心电图知识是有效监测心律失常的重要预测因素。因此,经常、持续z好的练习可增强提供优质护理服务的信心。
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引用次数: 0
Respiratory effort in mechanical ventilation weaning Prediction: An observational, case-control study 机械通气断奶时的呼吸强度预测:病例对照观察研究
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-11 DOI: 10.1016/j.iccn.2024.103831

Background

The diaphragm is crucial for ventilator weaning, but its specific impact on weaning indicators needs further clarification. This study investigated the variability in weaning outcomes across different diaphragm function populations and the value of respiratory drive and inspiratory effort in weaning.

Methods

This observational case-control study enrolled patients on mechanical ventilation for more than 48 h and completed a 30-minute spontaneous breathing trial (SBT) with pressure-support ventilation for the first time. After the SBT, airway pressure at 100 ms during occlusion (P0.1), inspiratory effort, and diaphragmatic ultrasound were evaluated to predict weaning outcomes. Weaning failure was defined as re-intubation within 48 h of weaning, the need for therapeutic non-invasive ventilation, or death.

Results

68 patients with a mean age of 63.21 ± 15.15 years were included. In patients with diaphragm thickness (DT) ≥ 2 mm, P0.1 (P=0.002), pressure-muscle index (PMI) (P=0.012), and occluded expiratory airway pressure swing (ΔPocc) (P=0.030) were significantly higher in those who failed weaning. Conversely, for patients with DT<2 mm, PMI (P=0.003) and ΔPocc (P=0.002) were lower in the weaning failure group. Additionally, within the DT≥2 mm group, P0.1 demonstrated a higher area under the curve (AUC) for weaning prediction (0.889 vs. 0.739) compared to those with DT<2 mm.

Conclusions

PMI and ΔPocc are predictive of weaning outcomes in patients with diaphragm thickness ≥ 2 mm, where the assessment value of P0.1 is notably higher. Diaphragm function significantly influences the accuracy of weaning predictions based on respiratory drive and inspiratory effort.

Implications for Clinical Practice

Our findings indicate that the effectiveness of respiratory drive and inspiratory effort in predicting successful weaning from mechanical ventilation may vary across different patient populations. Diaphragm function plays a crucial role in weaning assessments, particularly when using P0.1, the pressure-muscle index (PMI), and occluded expiratory airway pressure swing (ΔPocc).

背景膈肌对呼吸机断奶至关重要,但其对断奶指标的具体影响需要进一步明确。本研究调查了不同膈肌功能人群断奶结果的差异性,以及呼吸驱动和吸气努力在断奶中的价值。方法这项观察性病例对照研究纳入了使用机械通气超过 48 小时、首次使用压力支持通气完成 30 分钟自主呼吸试验(SBT)的患者。SBT 结束后,对闭塞期间 100 毫秒的气道压力(P0.1)、吸气力度和膈肌超声进行了评估,以预测断奶结果。断奶失败的定义是断奶后 48 小时内再次插管、需要治疗性无创通气或死亡。膈肌(DT)厚度≥2 毫米的患者中,断奶失败者的P0.1(P=0.002)、压力-肌肉指数(PMI)(P=0.012)和闭塞呼气道压力摆动(ΔPocc)(P=0.030)显著较高。相反,对于 DT<2 mm 患者,断奶失败组的 PMI(P=0.003)和 ΔPocc(P=0.002)较低。此外,在 DT≥2 mm 组中,与 DT<2 mm 组相比,P0.1 对断奶预测的曲线下面积(AUC)更高(0.889 vs. 0.739)。我们的研究结果表明,呼吸驱动力和吸气努力在预测机械通气成功断奶方面的有效性在不同的患者群体中可能有所不同。膈肌功能在断奶评估中起着至关重要的作用,尤其是在使用 P0.1、压力-肌肉指数 (PMI) 和闭塞呼气道压力摆动 (ΔPocc) 时。
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引用次数: 0
Music as healing in ICU survivors: The road ahead in seeking the right tone 音乐能治愈重症监护室的幸存者:寻找正确音调的前行之路
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-11 DOI: 10.1016/j.iccn.2024.103828
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引用次数: 0
Objective assessment of nursing workload in an intermediate care unit: A prospective observational study 客观评估中级护理病房的护理工作量:前瞻性观察研究
IF 4.9 2区 医学 Q1 NURSING Pub Date : 2024-09-09 DOI: 10.1016/j.iccn.2024.103767

Objectives

To systematically assess the nursing workload in an Intermediate Care Unit.

Design

Single-centre prospective observational study. The nursing activities within the initial 72 h of hospitalization were recorded on a prespecified chart and standardized as activities/5 min/patient/day.

Setting

This study was conducted at the Intermediate Care Unit of the Altovicentino Hospital (Italy) from September 1 to December 31, 2022.

Main outcome measure

We considered working overload as an average number of nursing activities/5 min/patient/day higher than the 85th percentile and investigated independent risk factors associated with it.

Results

A total of 183 patients were included. During their hospital stay, the average number of nursing activities per patient was 30 per 5-minute interval per day (range: 22–40). On the first day of hospitalization, the primary activities were predominantly administrative and managerial tasks. In contrast, on the second day, activities related to therapeutic management and primary care predominated. Various scores related to the patient’s condition, including comorbidity, functionality, frailty, intensity, and severity, were analyzed for their association with nursing workload using multivariate analysis. However, only the National Early Warning Score was found to be an independent risk factor for nursing workload overload (OR 1.399, 95 % CI 1.205–1.624, p < 0.001).

Conclusion

The study results demonstrated a significant variation in nursing workload within the same department. Subsequent studies are necessary to confirm the ability of the National Early Warning Score in predicting nursing over workload.

Implication for clinical practice

This study provides a detailed analysis of nursing workload in intermediate care settings, emphasizing the need for adequate resource allocation due to the potential for rapid deterioration in patients’ conditions. By correlating nursing activities with patient severity indices, such as the National Early Warning Score, the findings support more effective organizational strategies to enhance care for patients at high risk of health decline.

目的系统评估中级护理病房的护理工作量。主要结果测量我们认为工作负荷过重是指平均护理活动次数/5分钟/患者/天高于第85百分位数,并调查了与之相关的独立风险因素。住院期间,每位患者每天每5分钟的平均护理活动次数为30次(范围:22-40)。住院第一天,主要活动以行政和管理任务为主。相比之下,第二天的活动则以治疗管理和基础护理为主。采用多变量分析法分析了与患者病情有关的各种评分,包括合并症、功能性、虚弱程度、强度和严重程度,以确定它们与护理工作量的关系。然而,研究发现只有国家预警评分是护理工作量超负荷的独立风险因素(OR 1.399,95 % CI 1.205-1.624,p <0.001)。对临床实践的启示本研究对中级护理机构的护理工作量进行了详细分析,强调由于患者病情有可能迅速恶化,因此需要进行适当的资源分配。通过将护理活动与患者严重程度指数(如国家预警评分)相关联,研究结果支持采取更有效的组织策略,以加强对健康状况极有可能恶化的患者的护理。
{"title":"Objective assessment of nursing workload in an intermediate care unit: A prospective observational study","authors":"","doi":"10.1016/j.iccn.2024.103767","DOIUrl":"10.1016/j.iccn.2024.103767","url":null,"abstract":"<div><h3>Objectives</h3><p>To systematically assess the nursing workload in an Intermediate Care Unit.</p></div><div><h3>Design</h3><p>Single-centre prospective observational study. The nursing activities within the initial 72 h of hospitalization were recorded on a prespecified chart and standardized as activities/5 min/patient/day.</p></div><div><h3>Setting</h3><p>This study was conducted at the Intermediate Care Unit of the Altovicentino Hospital (Italy) from September 1 to December 31, 2022.</p></div><div><h3>Main outcome measure</h3><p>We considered working overload as an average number of nursing activities/5 min/patient/day higher than the 85th percentile and investigated independent risk factors associated with it.</p></div><div><h3>Results</h3><p>A total of 183 patients were included. During their hospital stay, the average number of nursing activities per patient was 30 per 5-minute interval per day (range: 22–40). On the first day of hospitalization, the primary activities were predominantly administrative and managerial tasks. In contrast, on the second day, activities related to therapeutic management and primary care predominated. Various scores related to the patient’s condition, including comorbidity, functionality, frailty, intensity, and severity, were analyzed for their association with nursing workload using multivariate analysis. However, only the National Early Warning Score was found to be an independent risk factor for nursing workload overload (OR 1.399, 95 % CI 1.205–1.624, p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The study results demonstrated a significant variation in nursing workload within the same department. Subsequent studies are necessary to confirm the ability of the National Early Warning Score in predicting nursing over workload.</p></div><div><h3>Implication for clinical practice</h3><p>This study provides a detailed analysis of nursing workload in intermediate care settings, emphasizing the need for adequate resource allocation due to the potential for rapid deterioration in patients’ conditions. By correlating nursing activities with patient severity indices, such as the National Early Warning Score, the findings support more effective organizational strategies to enhance care for patients at high risk of health decline.</p></div>","PeriodicalId":51322,"journal":{"name":"Intensive and Critical Care Nursing","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Intensive and Critical Care Nursing
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