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The effects of ZnO-insulin nanoparticles on some oxidative stress biochemical and physiological markers in rats with alloxan-induced diabetes 氧化锌-胰岛素纳米颗粒对阿脲诱导糖尿病大鼠部分氧化应激生化指标和生理指标的影响
Pub Date : 2024-07-18 DOI: 10.31185/jwsm.499
Hanan Sajjad AL-Iedani, Jafar Abass, Issa Al-Maamori, A. Rheima
In recent years, there has been a growing emphasis on nanomaterials, particularly in the realm of medical applications. Zinc oxide nanoparticles are widely recognized as a significant class of oxides of metals due to their inherent structural stability, little toxic effects, and ability to maintain cellular integrity. One of the most important medicinal uses of zinc oxide is medication administration. Twenty-four male albinos’ rats were randomly separated into four groups. Control group, diabetic group, diabetic group treated with insulin, and diabetic group treated with ZnO NPs loaded with insulin. The rats were given medication for 28 days. Diabetes mellitus was induced in the rats with blood sugar levels more than 250 mg/dL by administering alloxan intraperitoneally at a dose of 120 mg/kg. The nanoparticles' physicochemical properties were investigated using a variety of analytical techniques, including UV-Vis spectral analysis, X-ray diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM). The data revealed significant increases in glucose, cholesterol, triglyceride and total oxidative stress (TOS) as well as a notable decrease in body weight and catalase levels, in the diabetic control group compared to the healthy control group (P< 0.05). Compared to control groups, ZnO NPs loaded with insulin lower total cholesterol, triglycerides and TOS on the other hand increase body weight and catalase levels. The results of our study indicate that the use of photo-synthesized ZnO-NPs in combination with insulin showed noteworthy antidiabetic benefits when compared to the control groups.
近年来,人们越来越重视纳米材料,尤其是在医疗应用领域。氧化锌纳米粒子因其固有的结构稳定性、毒性小和保持细胞完整性的能力,被广泛认为是一类重要的金属氧化物。氧化锌最重要的医学用途之一是给药。24 只雄性白化大鼠被随机分为四组。对照组、糖尿病组、用胰岛素治疗的糖尿病组和用含胰岛素的氧化锌 NPs 治疗的糖尿病组。大鼠服药 28 天。通过腹腔注射阿脲,以 120 毫克/千克的剂量诱导大鼠患糖尿病,血糖水平超过 250 毫克/分升。使用多种分析技术,包括紫外可见光谱分析、X 射线衍射 (XRD) 和场发射扫描电子显微镜 (FE-SEM) 对纳米粒子的理化性质进行了研究。数据显示,与健康对照组相比,糖尿病对照组的葡萄糖、胆固醇、甘油三酯和总氧化应激(TOS)明显增加,体重和过氧化氢酶水平明显下降(P< 0.05)。与对照组相比,负载胰岛素的氧化锌氮氧化物降低了总胆固醇、甘油三酯和过氧化氢应激,另一方面增加了体重和过氧化氢酶水平。我们的研究结果表明,与对照组相比,光合成的 ZnO-NPs 与胰岛素结合使用具有显著的抗糖尿病功效。
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引用次数: 0
Identification of Candidate Transcription Factors that Bind to the ASCN Gene, Associated with Parkinson's Disease, Using Bioinformatics Analysis 利用生物信息学分析鉴定与帕金森病相关的 ASCN 基因结合的候选转录因子
Pub Date : 2024-06-06 DOI: 10.31185/jwsm.495
Muna A. Abdal Rhida
Parkinson's disease (PD) is a neurodegenerative illness marked by progressive damage of dopaminergic neurons in the substantia nigra. Synuclein-α protein plays a key role in this term by aggregating in clumps of Lewy bodies causing PD. Despite unclear etiology of PD, growing indications show that PD pathogenesis is associated with gene expression dysregulation. Transcription factors (TFs) are the key players in regulating gene expression. In this study, we employed a bioinformatics tool to predict TF binding to Synuclein-α (SNCA)gene utilizing DNA sequences, epigenetic modifications, TF binding motifs, and creating machine learning algorithms. PROMO database was utilized to identify candidate TFs. Here we found TFs that act as regulators of neuronal function and dopaminergic signaling pathways, including members of the Forkhead box family, and nuclear factor-kappa B family members such as c-Jun, and STATs family. These findings provide a better understanding of the molecular mechanisms underlying PD disease and determine potential therapeutic targets.
帕金森病(PD)是一种神经退行性疾病,以黑质多巴胺能神经元的进行性损伤为特征。在这一过程中,突触核蛋白-α蛋白起着关键作用,它聚集成路易体团,导致帕金森病。尽管帕金森病的病因不明确,但越来越多的迹象表明,帕金森病的发病机制与基因表达失调有关。转录因子(TFs)是调控基因表达的关键因素。在这项研究中,我们使用了一种生物信息学工具,利用DNA序列、表观遗传修饰、TF结合基序和创建机器学习算法来预测TF与突触核蛋白-α(SNCA)基因的结合。我们利用 PROMO 数据库确定了候选 TF。在这里,我们发现了作为神经元功能和多巴胺能信号通路调控因子的TFs,包括叉头盒家族成员、核因子-kappa B家族成员(如c-Jun)和STATs家族成员。这些发现有助于更好地了解帕金森病的分子机制,并确定潜在的治疗靶点。
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引用次数: 0
Study the Effect of “Di-dodecyl amine” as a Corrosion Inhibitor for Carbon Steel in HCl Medium 研究 "二十二烷基胺 "作为盐酸介质中碳钢缓蚀剂的效果
Pub Date : 2024-05-10 DOI: 10.31185/jwsm.491
Amel D. Hussein, Raheem A. H. Al-Uqaily
Numerous organic compounds have been investigated for their potential to reduce corrosion under various circumstances. This study investigated the effects of di-dodecyl amine, an organic chemical, on carbon steel metal corrosion at different temperatures while HCl acid was present. The examination was carried out using accepted methods for polarization, weight loss, and corrosion process testing. The obtained findings demonstrated that the corrosion rate reduces with increasing inhibitor concentration, leading to increased inhibition efficiency. Furthermore, as shown in the weight loss technique, the corrosion rate lowers with increasing surface coverage with organic inhibitor at 313 °C. In the anodic and cathodic polarization methods, as well as in the inhibition efficiency, it is observed to see the cathodic and anodic curves through which the occurrence of the potential and corrosion current is known. The current and corrosion potential decreases with increasing inhibitor concentration. The amines and methyl motiveless in this inhibitor's composition give it their efficacy since they may coat the metal surface and stop corrosion
人们研究了许多有机化合物在各种情况下减少腐蚀的潜力。本研究调查了有机化学品二十二烷基胺在不同温度下对存在盐酸的碳钢金属腐蚀的影响。研究采用了公认的极化、失重和腐蚀过程测试方法。研究结果表明,腐蚀速率随着抑制剂浓度的增加而降低,从而提高了抑制效率。此外,如失重技术所示,在 313 ℃ 下,腐蚀速率随着有机抑制剂表面覆盖率的增加而降低。在阳极和阴极极化方法以及抑制效率中,可以观察到阴极和阳极曲线,通过这些曲线可以知道电位和腐蚀电流的发生情况。电流和腐蚀电位随着抑制剂浓度的增加而降低。这种抑制剂成分中的胺和无甲基动因可包裹金属表面并阻止腐蚀,因此具有一定的功效。
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引用次数: 0
Study The Thermal Conductivity of Polymethyl Methacrylate Reinforcing with Cotton, Hair, and Burlap 研究用棉花、头发和麻布增强聚甲基丙烯酸甲酯的导热性能
Pub Date : 2024-05-10 DOI: 10.31185/jwsm.492
Zuhair Salim Khamees, Asmaa Shawqy Khaleel
This study includes the manufacture of two sets of composite materials consisting of polymethyl methacrylate reinforced with natural fibers. The first (R) group included eight layers of cotton with one layer of hair in the middle, and the second (O) group included six layers of cotton with three layers of burlap in the middle. The thermal conductivity of the two groups was checked using a Lee disc to identify the thermal conductivity (K), of group R  0.0771 w/m.c, and of group O 0.0754 w/m.c. These values are considered good as the material has good thermal insulation due to its low thermal conductivity values and is therefore suitable for use in prosthetic limbs as it can preserve the body temperature from external influences.
这项研究包括制造两组由天然纤维增强的聚甲基丙烯酸甲酯组成的复合材料。第一组(R)包括八层棉花,中间有一层头发,第二组(O)包括六层棉花,中间有三层麻布。使用李氏圆盘检测了两组的导热系数(K),R 组为 0.0771 w/m.c,O 组为 0.0754 w/m.c。这些数值被认为是良好的,因为材料的导热系数低,具有良好的隔热性,因此适合用于假肢,因为它可以保持体温不受外界影响。
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引用次数: 0
Eco-Friendly Production of Metal Nanoparticles Through Plant Extract Besides Their Assessment of Antibacterial, and Antifungal activity 通过植物提取物以生态友好方式生产金属纳米颗粒并评估其抗菌和抗真菌活性
Pub Date : 2024-05-08 DOI: 10.31185/jwsm.488
Nasser Nafaa, Abrahem Alqurashy
A green-synthesis method for silver nanoparticles (Ag NPs) is a scientific breakthrough. Using sunflower plant extracts, this approach uses metallic and botanical synergy. Naturally occurring and renewable extracts reduce, chelate, stabilize, bind, and precipitate. The Ag nanoparticles' X-ray diffraction (XRD) crystal structure was cubic. Average nanoparticle crystallite size was 31.18 nm. Energy-dispersive X-ray spectroscopy (EDX) detected silver. Field Emission Scanning Electron Microscope (FESEM) examination revealed that the particles were Ag (silver) and spherical, averaging 31.23nm. Diffuse Reflectance Spectroscopy also indicated a 2.7 eV optical gap. Using many characterization methods, nanostructured silver was synthesized during this procedure. Biological efficacy assays can evaluate hierarchically porous silver's antibacterial properties. In the previous five years, strategies against Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus mutans, Ecoli, and Candida albicans, Penicillium spp., and Aspergillus spp. were essential. Data demonstrates that these structures are attractive antibacterial choices. A majority of Ag NPs are natural bacterium substitutes for Staphylococcus aureus, pseudomonas aeruginosa, Streptococcus mutans, and Ecoli. Also against various fungi: The immune systems of immunocompromised hosts are threatened by yeasts such Candida albicans, Penicillium, and Aspergillus.measured. It calls into doubt the study's efficacy in antibacterial and other applications.
银纳米粒子(Ag NPs)的绿色合成方法是一项科学突破。这种方法使用向日葵植物提取物,利用金属和植物的协同作用。天然可再生的提取物具有还原、螯合、稳定、结合和沉淀作用。银纳米粒子的 X 射线衍射(XRD)晶体结构为立方体。纳米颗粒的平均结晶尺寸为 31.18 纳米。能量色散 X 射线光谱(EDX)检测到了银。场发射扫描电子显微镜(FESEM)检查显示,颗粒为银,呈球形,平均粒径为 31.23 纳米。漫反射光谱也显示出 2.7 eV 的光隙。利用多种表征方法,在此过程中合成了纳米结构银。生物药效试验可评估分层多孔银的抗菌特性。在过去五年中,针对金黄色葡萄球菌、铜绿假单胞菌、变异链球菌、大肠杆菌、白色念珠菌、青霉属和曲霉属的抗菌策略至关重要。数据表明,这些结构是具有吸引力的抗菌选择。大多数银氧化物是金黄色葡萄球菌、铜绿假单胞菌、变异链球菌和大肠杆菌的天然细菌替代物。还能对抗各种真菌:免疫力低下的宿主的免疫系统会受到白色念珠菌、青霉和曲霉等酵母菌的威胁。这使人们对该研究在抗菌和其他应用方面的功效产生怀疑。
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引用次数: 0
Using Phragmites australis plants as activated carbon to remove Mn(II), and Cu(II) ions from different aqueous solutions 利用葭藻作为活性炭去除不同水溶液中的锰(II)和铜(II)离子
Pub Date : 2024-05-08 DOI: 10.31185/jwsm.490
Salam Hussein, Talib, Firas Ali, Hussein Mohammed Khlaif, Challab
This study investigates the use of agricultural byproducts of plants (Phragmites australis) as low-cost adsorbents for the removal of Cu2+ and Mn2+ from their aqueous solutions through the production of (AC). The results showed that the adsorption equilibrium time for both ions was 30 minutes. The results obtained showed that pH=5, pH=6 for Cu2+ and Mn2+ respectively were optimum to adsorption for these ions. The study showed that the weight (0.5 g) of the adsorbent was ideal to achieve the best adsorption and the ability of the adsorbents to adsorb  metal ions was as follows: Cu(II) > Mn(II).
本研究探讨了利用农业植物副产品(葭)作为低成本吸附剂,通过生产(AC)去除水溶液中的 Cu2+ 和 Mn2+。结果表明,两种离子的吸附平衡时间均为 30 分钟。结果表明,Cu2+ 和 Mn2+ 的最佳吸附pH 值分别为 5 和 6。研究表明,吸附剂的重量(0.5 克)是达到最佳吸附效果的理想选择,吸附剂对金属离子的吸附能力如下:Cu(II)>Mn(II)。
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引用次数: 0
Optical, Structural, and Morphological Characterization of Titanium Oxide (TiO2) Nanoparticles from Laser Ablation in Deionized Water 去离子水中激光烧蚀产生的氧化钛 (TiO2) 纳米颗粒的光学、结构和形态特征
Pub Date : 2024-05-08 DOI: 10.31185/jwsm.489
Najlaa Jerjack
In this research, we focus on the synthesis of titanium oxide (TiO2) nanoparticles using the Nd:Utilization of YAG laser pulse ablation technique in liquid environments, with pulse energies from 100 to 500 millijoules. The process employs a Nd:YAG laser operating at a frequency of 6 Hz and a wavelength of 1064 nm. (The TiO2 nanoparticles synthesized in this study could be used in different high-temperature environments, as they are characterized by favorable physical, chemical, and mechanical properties). The synthesized product was further treated by calcination for four hours at temperatures higher than 600°C which promoted crystalline structure in the lattice. Comprehensive analyses were carried out to determine the nanoparticles' features. Optical features were studied through UV-visible spectroscopy to examine the absorption spectrum and band gap. The detailed examination of the crystal and surface structures was done using X-ray diffraction and field emission scanning electron microscopy (FE-SEM), in order to obtain insight into the structural integrity and the morphology of the titanium oxide nanoparticles. The study provides a deeper insight into TiO2 nano particle production and their characteristics, thereby emphasizing their suitability for advanced material applications.
在这项研究中,我们重点关注在液体环境中使用 Nd:Utilization of YAG 激光脉冲烧蚀技术合成氧化钛 (TiO2) 纳米粒子,脉冲能量从 100 毫焦到 500 毫焦不等。该工艺采用频率为 6 赫兹、波长为 1064 纳米的 Nd:YAG 激光器。(本研究中合成的 TiO2 纳米粒子可用于不同的高温环境,因为它们具有良好的物理、化学和机械性能)。合成的产品还需在高于 600°C 的温度下煅烧四小时,以促进晶格的结晶结构。为了确定纳米粒子的特征,对其进行了综合分析。通过紫外可见光谱研究了吸收光谱和带隙的光学特征。利用 X 射线衍射和场发射扫描电子显微镜(FE-SEM)对晶体和表面结构进行了详细检查,以深入了解氧化钛纳米粒子的结构完整性和形态。这项研究加深了人们对二氧化钛纳米粒子的生产及其特性的了解,从而强调了它们在先进材料应用中的适用性。
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引用次数: 0
Histological manifestations of the Cervix with Chronic Cystic Cervicitis and Nabothian Cyst: Case Report 宫颈组织学表现与慢性宫颈糜烂和纳博氏囊肿:病例报告
Pub Date : 2024-04-24 DOI: 10.31185/jwsm.487
Marwa Jamal Hussain, Al Kinani
         Nabothian cysts are non-malignant lesions that occur on the cervix and affect a large percentage of reproductive aged women. They usually occur because of childbirth or minor trauma; most of the time, they are small and asymptomatic and require no treatment. However, large nabothian cysts may vary in appearance and even resemble malignant tumors. Consequently, in order to rule out malignancy, a biopsy is advised. The greatest valuable imaging modalities for cervical cystic lesions are MRI and transvaginal ultrasonography. Nabothian cysts usually don't need any treatment, but if the lesion's nature is unclear and it hurts, surgery may be necessary. In this case study, chronic pelvic pain is described and abnormal uterine bleeding needed surgical intervention because of chronic cystic cervicitis and multiple nabothian cysts accompanied with Leiomyoma accompanied with adenomyosis and endometrial hyperplasia without atypia.
纳博氏囊肿是发生在子宫颈上的非恶性病变,影响着很大一部分育龄妇女。它们通常因分娩或轻微外伤而发生;大多数情况下,囊肿较小且无症状,无需治疗。然而,大的纳博氏囊肿外观可能会有所不同,甚至类似于恶性肿瘤。因此,为了排除恶性肿瘤,建议进行活检。对宫颈囊性病变最有价值的影像学检查方法是核磁共振成像和经阴道超声波检查。纳博氏囊肿通常不需要任何治疗,但如果病变性质不清且有疼痛感,则可能需要手术治疗。在本病例研究中,描述了慢性盆腔疼痛和异常子宫出血需要手术干预的情况,原因是慢性宫颈囊炎和多发性纳博氏囊肿伴有子宫内膜异位症和子宫内膜增生症,其中子宫内膜增生症伴有子宫腺肌病。
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引用次数: 0
Proposed Development of NTRU Public Key Cryptosystem 拟议开发 NTRU 公钥密码系统
Pub Date : 2024-03-13 DOI: 10.31185/jwsm.485
Marwah Aearaby Sayyid
As life progresses and develops, cryptography has become an indispensable science. The development of this science has given flexibility and security in exchanging information and data of various kinds by making it difficult for unauthorized persons to access them. In this paper, we proposed a new NTRU-like encryption scheme using a different mathematical structure for the public key, as well as for text encryption and decryption to have more resistance to attacks, which makes this method suitable for many applications.
随着生活的进步和发展,密码学已成为一门不可或缺的科学。这门科学的发展为各种信息和数据的交换提供了灵活性和安全性,使未经授权者难以获取这些信息和数据。在本文中,我们提出了一种新的类似于 NTRU 的加密方案,它使用不同的数学结构来处理公钥以及文本加密和解密,从而具有更强的抗攻击能力,使这种方法适用于许多应用领域。
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引用次数: 0
Simulation of Organic Coating Penetration on Metal Using Impedance Spectroscopy 利用阻抗光谱学模拟有机涂层对金属的渗透
Pub Date : 2024-03-10 DOI: 10.31185/jwsm.484
Ahmed Qasim
This paper proposes an alternative model for simulating electrochemical impedance spectra of protective organic coatings on the metal substrate. It describes broadening of the semicircle in the complex plane (Nyquistplot) and Bode plots behavior using commercial software Software ZSimpWin 3.22 in the absence and with of corrosion reactions. Before this process, the appropriate modified electrical equivalent circuit had selected where constant phase element had used instead of a capacitor for reach to reality. The result helps to understand the system under study i.e. the change of impedance behavior with electrochemical processes.
本文提出了一种模拟金属基底上有机保护涂层电化学阻抗谱的替代模型。它使用商用软件 ZSimpWin 3.22 描述了在无腐蚀反应和有腐蚀反应的情况下,复平面内半圆(奈奎斯特图)和 Bode 图的拓宽行为。在此过程之前,选择了适当的修正电气等效电路,其中使用了恒定相位元件来代替电容器,以符合实际情况。结果有助于理解所研究的系统,即阻抗行为随电化学过程的变化。
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引用次数: 0
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Journal of Wasit for Science and Medicine
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