Chemistry of Natural Compounds最新文献

A new diamine, mahodiamine (1), along with 11 compounds, including scopoletin (2), isoscopoletin (3), aesculetin dimethyl ester (4), p-methoxylbenzoic acid (5), protocatechuic acid (6), ferulic acid (7), (+)-vomifoliol (8), (+)-dehydrovomifoliol (9), (Z)-4-hydroxy-3,5,5-trimethyl-4-(3′-oxobut-1′-enyl)cyclohex-2-enone (10), bis(2-ethylhexyl) terephthalate (11), and dibutyl phthalate (12), were isolated from the leaves of Mahonia fortunei (Lindl.) Fedde (Berberidaceae). The structure of the new diamine was elucidated by chemical and physical evidence.

To investigate the impact of C3-methyl substitution of naphtho[1,2-b]furan-4,5-dione analogs on antitumor efficacy, 16 NQO1 substrate analogs of C3-methylated (TC1–TC8) and C3-demethylated (TC1′–TC8′) were synthesized. The anticancer activities against K562, LNCaP, HeLa, and MDA-MB-231 suggested that methyl and demethyl derivatives of naphtho[1,2-b]furan-4,5-dione analogs have comparable cytotoxicity and this value depends more on the nature of the substituent at position C-2.

A new tetraazacyclododecane, 2-nonyl-1,4,7,10-tetraazacyclododecane (1), along with nine isoquinoline alkaloids, northalifoline (2), thalifoline (3), corydaldine (4), N-methylcorydaldine (5), oxyberberine (6), berberine (7), palmatine (8), jatrorrhizine (9), and columbamine (10) were isolated from the bark of Ilex latifolia (Aquifoliaceae). The structure of the new tetraazacyclododecane was elucidated by chemical and physical evidence.

A new chromone, 5-hydroxy-2-methoxy-6,7,8-trimethylchromone (1), along with ten known compounds including 5,7-dimethoxychromone (2), 5-hydroxy-7-methoxychromone (3), 5-hydroxychromone (4), 5,7-dihydroxy-2,6-dimethylchromone (5), 5,7-dihydroxy-2,8-dimethyl-chromone (6), 5,7-dihydroxy-2,6,8- trimethylchromone (7), (3S,4R)-4-hydroxymellein (8), (3S,4S)-4-hydroxymellein (9), 4-hydroxymethyl-3,5-dimethyldihydro-2-furanone (10), and 3,4-dihydroxy-3-methyldihydro-2-furanone (11), were isolated from the roots of Haworthia cooperi var. truncata (Asphodelaceae). The structure of the new chromone derivative was elucidated by chemical and physical evidence.

Progress during the period 2016–2024 on the synthesis and transformations of A-seco-triterpene derivatives is reviewed and analyzed. Information on their pharmacological potential is given.

A novel glycoside compound, 3-hydroxy-5-(β-D-glucopyranosyloxy)-hexanoic acid (1) has been isolated from the fruits of Aronia melanocarpa (Michx.) Britton, along with ten known compounds, vanillic acid 4-O-β-D-glucoside (2), (R)-4-O-β-D-glucopyranoyl-4-hydroxy-2-pentanone (3), (6R,9R)-roseoside (4), phloroacetophenone 2-O-glucoside (5), methyl (3S,5S)-5-hydroxy-3-(β-D-glucopyranosyloxy)hexanoate (6), β-D-glucopyranosyl benzoate (7), parasorboside (8), benzyl 6-O-α-L-arabinofuranosyl-β-D-glucoside (9), dihydrophasmaric acid 4′-O-β-D-glucopyranoside (10), and 4-O-β-D-glucopyranosyl-cis-p-coumaric acid (11). The structure of compound 1 was determined by NMR spectroscopic and MS analyses. Compounds 1–4 showed antibacterial activity against Staphylococcus aureus RN (4220).

The glucoarabinogalactan GAG-Sco with MM 15 kDa was obtained by fractionation of water-soluble polysaccharides from Scutellaria comosa Juz. An analysis of the monosaccharide residues showed that GAG-Sco consisted of arabinose (35.7%), glucose (25.8%), and galactose (27.7%). Chemical analyses and ¹H and ¹³C NMR spectroscopic data found that the main chain of the GAG-Sco macromolecule consisted of 1,6-bound D-galactopyranosyl residues. A side chain in the C-2 position contained glucose, arabinose, and the oligosaccharide fragment α-Araf-(5→1)-α-Araf. The water-soluble polysaccharide from S. comosa was shown to affect phagocytosis, specifically the phagocytic index of neutrophils.