Chemistry of Natural Compounds最新文献

The herb of Nonea rossica Steven (Boraginaceae) contained 23 compounds, including new acetates of astragalin and trifolin (1–5). UV and NMR spectroscopy and mass spectrometry found that the new flavonoids were kaempferol 3-O-(3′′-O-acetyl)-β-D-glucopyranoside (noneaside B, 1), kaempferol 3-O-(3′′-O-acetyl)-β-D-galactopyranoside (noneaside C, 2), kaempferol 3-O-(4′′-O-acetyl)-β-Dglucopyranoside (noneaside D, 3), kaempferol 3-O-(4′′-O-acetyl)-β-D-galactopyranoside (noneaside E, 4), and kaempferol 3-O-(3′′,6′′-di-O-acetyl)-β-D-galactopyranoside (noneaside F, 5).

A new neolignan derivative, myrisellipin (1), has been isolated from the seeds of Myristica elliptica var. simiarum, together with seven known compounds, licarin A (2), accuminatin (3), butein (4), 3′-hydroxypterostilbene (5), malabaricone B (6), malabaricone C (7), and 3-(3,4,5-trimethoxyphenyl)-2-(E)-propen-1-ol (8). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, 1, 4, 5, 7, 8 showed potent inhibition, with IC₅₀ values of 16.83 ± 1.18, 17.92 ± 1.28, 25.06 ± 2.01, 22.05 ± 1.74, and 23.58 ± 1.96 μM respectively, against LPS-induced NO generation. In addition, compounds 4, 5, and 8 also showed potent DPPH radical scavenging activities, with IC₅₀ values of 37.02 ± 2.89, 80.36 ± 5.78, and 50.07 ± 4.11 μM, respectively.

Vietnamese ginseng (Panax vietnamensis), one of the famous Panax genus, is distributed and cultivated in the central area of Vietnam. This study investigates the chemical profile of the leaf part of the title plant, and has led to the isolation of one new alcohol glycoside and four ginsenosides. The structures of the obtained compounds were established as (2S)-pentyl-2-ol 2-O-β-D-apiofuranosyl-(1→6)-β-D- glucopyranoside (1, new compound), vina-ginsenoside R24 (2), ginsenoside Rg1 (3), ginsenoside Rb1 (4), and ginsenoside Rd (5), respectively, by extensive spectroscopic analyses, including NMR spectroscopy and mass spectrometry, as well as comparison with the literature data.

One previously undescribed imide analogue M7 (1), along with three known ones, methyl palmitate (2), methyl linoleate (3) and ergosterol peroxide (4), were isolated from the EtOAc extract of the culture broth of an actinobacteria Streptomyces sp. M7. The structure was elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data.

A new alkaloid, (S)-1-methyl-2-nitroso-1,2,3,4-tetrahydroisoquinoline-6,7-diol (1), named oleraisoquinoline A, and 9 known compounds, iseluxine (2), oleracrylimide E (3), oleracrylimide A (4), oleracrylimide B (5), chrysoeriol (6), 2-(2-hydroxyphenyl)-5,7-dimethoxychroman-4-one (7), portulacanone C (8), portulacanone D (9), and 2,2′-dihydroxy-4′,6′-dimethoxychalcone (10), were obtained from P. oleracea, in which, compounds 6, 7 were isolated from the plant for the first time. The structure of compound 1, identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR, and CD, presented remarkable anti-inflammatory and antioxidant activities, as also did compound 2, while 6 presented antioxidant activities.

A new flavonol glycoside that was called rosanoside was isolated from the aerial part of the plant Oxytropis rosea. Its structure was established by analyzing data from ¹H and ¹³C NMR spectra and DEPT, HSQC, and HMBC experiments. Rosanoside had the structure rhamnocitrin-3-O-(6′′-crotonoyl-β-D-glucopyranoside).