Recent advances and interest in nonpharmacological treatment approaches for various chronic pain conditions in adolescent patients have increased. Cognitive behavioral therapy (CBT) is widely regarded as the leading nonpharmacological treatment for chronic pain, encompassing gynecological conditions associated with chronic pelvic pain, such as endometriosis. Adolescents with endometriosis often present with different symptoms than adults and frequently report more comorbid psychiatric disorders than the general public. This review aims to (1) justify the application of CBT interventions in the context of adolescent patients with endometriosis; (2) integrate and analyze existing empirical evidence and reviews; (3) highlight the advantages, constraints, and future research directions in CBT for this demographic; and (4) introduce a novel biopsychosocial conceptual model. This model intricately considers the interplay of thoughts, emotions, behaviors, and physical symptoms specific to adolescents with endometriosis, providing a foundation for targeted CBT interventions. This holistic approach recognizes the multifaceted nature of their experience, paving the way for comprehensive and effective nonpharmacological therapeutic strategies. Given the nuanced and intricate nature of endometriosis in adolescents, there is a pressing need for innovative conceptual models and clinical trials of behavioral interventions explicitly designed for this demographic.
Caregivers of children with cancer face a myriad of stressors related to caring for their child that can place them at risk for mental health concerns above and beyond that of the average adult. Additionally, they grapple with the existential distress caused by the possibility that they may outlive their child. Caregiver distress is not only problematic for their own emotional, spiritual, social, and physical well-being, but also affects the family unit and can interfere with aspects of the child’s treatment. Clinicians trained in cognitive behavioral therapy (CBT) are well suited to support caregivers. Moreover, there is a strong evidence base for using interventions that incorporate cognitive and behavioral approaches with caregivers of children with cancer. We describe CBT’s application to this population through several case examples and also highlight important special considerations.

