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Narrative Exposure Therapy for a Traumatic Birth Experience With the Non-Birthing Parent: A Single Case Study 针对非生育父母的分娩创伤经历的叙事暴露疗法:单个案例研究
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.05.006
Allison Peipert, Marissa J. Ward, Michelle L. Miller
Traumatic birth experiences are common and can be extremely damaging to an individual’s health and well-being. Perinatal posttraumatic stress disorder (PTSD) is a common complication following a traumatic birth experience. While emerging literature has focused on interventions to reduce maternal PTSD, there is virtually no clinical information on interventions targeting perinatal PTSD for the nonbirthing person following a traumatic birth experience. This case series is presented to demonstrate how Narrative Exposure Therapy (NET) can be used to address the unique needs of a non-birthing person following a traumatic birth experience.
A patient sought treatment following witnessing his wife’s unexpected traumatic birth experience and subsequent placement of his daughter in the neonatal intensive care unit. Treatment was conducted at a specialty PTSD clinic through an urban academic medical center in the Midwestern United States. An advanced clinical psychology student conducted 10 sessions of NET under the supervision of a licensed clinical psychologist. NET treatment included psychoeducation, laying the lifeline (i.e., outlining significant events related to the birth experience), 6 imaginal exposures, a final reading of exposure transcripts, and a termination session. Patient-reported outcome measures were collected at baseline, week 8, and following treatment termination. The patient demonstrated a substantial reduction in PTSD, depressive, and dissociation symptoms and reported subjective improvement with NET. At termination, the patient no longer met criteria for PTSD. This case study provides guidance for a valuable treatment option for a nonbirthing partner’s PTSD following childbirth and highlights future directions for parental PTSD treatment.
创伤性分娩经历是常见的,可能对个人的健康和福祉造成极大的损害。围产期创伤后应激障碍(PTSD)是创伤性分娩后常见的并发症。虽然新兴文献关注的是减少产妇创伤后应激障碍的干预措施,但实际上没有临床资料表明针对分娩创伤后未分娩的人的围产期创伤后应激障碍的干预措施。本案例系列展示了如何使用叙事暴露疗法(NET)来解决创伤性分娩经历后未分娩的人的独特需求。一名患者在目睹其妻子意外的分娩创伤经历并随后将其女儿安置在新生儿重症监护病房后寻求治疗。治疗通过美国中西部的一个城市学术医疗中心在一个专门的创伤后应激障碍诊所进行。一名高级临床心理学学生在一名持牌临床心理学家的监督下进行了10次NET治疗。NET治疗包括心理教育、铺设生命线(即概述与分娩经历相关的重要事件)、6次想象暴露、暴露记录的最终阅读和终止会话。在基线、第8周和治疗结束后收集患者报告的结果测量。患者表现出创伤后应激障碍、抑郁和分离症状的显著减少,并报告了NET的主观改善。终止治疗时,患者不再符合PTSD的标准。本案例研究为非生育伴侣分娩后的创伤后应激障碍提供了有价值的治疗选择,并强调了父母创伤后应激障碍治疗的未来方向。
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引用次数: 0
Suicidal Ideation as a Maladaptive Emotion Regulation Strategy: Implications for Treatment in Dialectical Behavior Therapy 自杀意念是一种适应不良的情绪调节策略:对辩证行为疗法治疗的启示
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.10.001
Alma M. Bitran, Evan M. Kleiman, Shireen L. Rizvi
Dialectical behavior therapy (DBT) is a leading psychotherapy for the reduction of suicidal and self-injurious behaviors (SIBs). However, evidence shows that DBT may be comparably less effective at reducing suicidal ideation (SI) than SIBs. Improving the effectiveness of DBT for SI is critical, given that SI poses risk for SIBs and presents a substantial clinical burden. In the following theoretical paper, we first review evidence surrounding the effectiveness of DBT for SI reduction and explore why DBT may be comparably less effective at reducing SI than SIBs. We argue that DBT’s effectiveness for treating SI may be enhanced by a functional understanding of SI as a maladaptive form of affect regulation, as put forth by recent empirical research. Finally, we discuss implications of this model for treatment in DBT and provide clinical recommendations for how to target SI more effectively using DBT’s existing repertoire for behavior change.
辩证行为疗法(DBT)是减少自杀和自残行为(SIBs)的主要心理治疗方法。然而,有证据表明,DBT在减少自杀意念(SI)方面的效果可能不如sib。提高DBT治疗SI的有效性至关重要,因为SI会给sib带来风险,并带来巨大的临床负担。在下一篇理论论文中,我们首先回顾了DBT减少SI有效性的证据,并探讨了为什么DBT在减少SI方面的效果可能不如sib。我们认为,正如最近的实证研究所提出的那样,对SI作为一种不适应的情感调节形式的功能性理解可能会增强DBT治疗SI的有效性。最后,我们讨论了该模型对DBT治疗的影响,并就如何利用DBT现有的行为改变机制更有效地针对SI提供了临床建议。
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引用次数: 0
A Pilot CBT-Based Group Mental Health Intervention for Sexual and Gender Minority Asylum Seekers 基于cbt的性和性别少数寻求庇护者群体心理健康干预试点
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.10.002
Samara D. Fox, Emily Mellen, John E. Pachankis
This study investigated the feasibility and acceptability of a culturally adapted group therapy intervention for SGM asylum seekers. From an initial pool of 16 eligible individuals contacted, 5 completed a majority of the intervention group sessions as well as exit interviews. Thematic analysis of these interview transcripts, as well as a case study of one participant, suggested that participants had a positive perception of the intervention and developed new cognitive behavioral therapy skills, including distress tolerance, cognitive flexibility, assertiveness, and self-compassion skills. Themes identified included a reduction in social isolation, enhanced solidarity, and heightened motivation for therapy engagement. Participants expressed preferences for culturally relevant discussion topics and identified the importance of privacy and personalized attention in the individual sessions that supplemented the group program. Despite logistical hurdles and variable engagement levels, the studied intervention has the potential to alleviate mental health morbidity in this underserved and vulnerable population, as well as spark interest in further engagement in therapy.
本研究探讨了文化适应的团体治疗干预对SGM寻求庇护者的可行性和可接受性。从最初接触的16名符合条件的个人中,有5人完成了大多数干预小组会议以及退出面谈。对访谈记录的专题分析以及对一位参与者的个案研究表明,参与者对干预有积极的看法,并发展了新的认知行为治疗技能,包括痛苦容忍、认知灵活性、自信和自我同情技能。确定的主题包括减少社会孤立、加强团结和提高参与治疗的动机。参与者表达了对与文化相关的讨论主题的偏好,并确定了在补充小组计划的个别会议中隐私和个性化关注的重要性。尽管存在后勤障碍和不同的参与水平,研究的干预措施有可能减轻这一服务不足和弱势群体的心理健康发病率,并激发对进一步参与治疗的兴趣。
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引用次数: 0
Group-Delivered Trauma-Focused CBT Integrating Racial Socialization: A Multiple Case Study 以群体传递创伤为中心的CBT整合种族社会化:一个多案例研究
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.08.002
Amy Hyoeun Lee, Jamilah Silver, Jenny Shen, Wilfred Farquharson, Kristin Bernard, Isha Metzger
In addition to disparities in interpersonal trauma exposures, Black youth in the U.S. experience the compounding stress of racial trauma, both of which are associated with a disproportionate mental health burden. Black youth also face barriers to engaging with trauma-specific therapies to address trauma-related mental health problems, with research suggesting that they are less likely to complete trauma-specific treatment. Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) is an evidence-based therapy for trauma-related mental health problems in youth ages 3 to 18. Metzger and colleagues (2021) proposed a set of cultural considerations for Black families to address racial stressors and enhance engagement in TF-CBT. The aim of the current multiple case study was to demonstrate the utility of group-delivered TF-CBT integrating these considerations for a single telehealth group of Black adolescents and their caregivers. We describe the intervention, patient engagement and clinical outcomes, and feedback from families regarding their experience with the group model. We also outline clinical and implementation challenges and highlight directions for future research and clinical practice.
除了人际创伤暴露方面的差异外,美国黑人青年还经历着种族创伤的复合压力,这两者都与不成比例的心理健康负担有关。黑人青年在接受创伤特异性治疗以解决与创伤相关的心理健康问题方面也面临障碍,研究表明,他们不太可能完成创伤特异性治疗。以创伤为中心的认知行为疗法(TF-CBT)是一种针对3至18岁青少年创伤相关心理健康问题的循证疗法。Metzger及其同事(2021)为黑人家庭提出了一套文化考虑因素,以解决种族压力因素并增强对TF-CBT的参与。当前多案例研究的目的是证明群体交付TF-CBT整合这些考虑因素对黑人青少年及其照顾者的单一远程医疗群体的效用。我们描述了干预、患者参与和临床结果,以及来自家庭的反馈,关于他们对小组模式的体验。我们还概述了临床和实施的挑战,并强调了未来研究和临床实践的方向。
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引用次数: 0
Values Work With Adolescents: A Qualitative Component Analysis Using an Integrative Model of Values and Behavior 青少年价值观工作:使用价值观与行为整合模型的定性成分分析
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.08.001
Sandra M. Fortier, Elizabeth Strand, Lisa K. Zottarelli, Madeleine Stevens, Cary M. Springer
Adolescence is a time of vulnerability to psychological distress and emotional disorders, necessitating effective and developmentally appropriate treatment. Acceptance and commitment therapy (ACT) is an evidence-based intervention with values work at the heart of the method. Values work involves clinical interventions that shore up a client’s ability to act in alignment with their personal values, a practice evidenced to improve psychological well-being. However, there is a dearth of research into the process of values work within ACT and values work research with adolescents is even more sparse. The current study aims to clarify values work with adolescents. We used a qualitative online survey of 28 ACT clinicians. Responses were analyzed using defined content analysis with a research-based integrative model of values and behavior (IMVB). Analysis indicated the IMVB’s mechanisms were prevalent across and within surveys, suggesting applicability to clinical values work interventions. The IMVB functioned to clarify components and adaptations of values work with adolescents. Several themes were generated outside of the IMVB, suggesting adolescents have further developmental needs during values work. Results indicate distinct alterations may be warranted for effective values work with adolescents. The IMVB may have further utility for exploring research and clinical inquiry into ACT values work.
青春期是一个易受心理困扰和情绪障碍影响的时期,需要有效和与发育相适应的治疗。接受和承诺疗法(ACT)是一种基于证据的干预方法,其核心是价值观工作。价值观工作涉及临床干预,支持客户按照个人价值观行事的能力,这种做法被证明可以改善心理健康。然而,对ACT中价值观工作过程的研究缺乏,对青少年价值观工作的研究更是稀少。本研究旨在阐明青少年价值观工作。我们对28名ACT临床医生进行了定性在线调查。使用基于研究的价值观和行为整合模型(IMVB)的定义内容分析来分析响应。分析表明,IMVB的机制在调查中普遍存在,表明其适用于临床价值工作干预。IMVB的作用是澄清青少年价值观工作的组成部分和适应性。在IMVB之外产生了几个主题,表明青少年在价值观工作中有进一步的发展需求。结果表明,明显的改变可能保证有效的价值观工作与青少年。IMVB可以进一步用于探索研究和临床调查ACT值的工作。
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引用次数: 0
Intensive Group Behavioral Treatment for Older Youth With Selective Mutism: An Open Trial 老年青年选择性缄默症的强化团体行为治疗:一项公开试验
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.08.004
Rachel Kupferberg, Shelley Avny, Camilo Ortiz
Selective mutism (SM) is an anxiety disorder characterized by an inability to speak in social situations, despite comfortably speaking in familiar situations (American Psychiatric Association, 2022). To date, research has demonstrated the effectiveness of cognitive-behavioral therapy (CBT) models, including both weekly CBT and intensive group behavioral treatment for younger children with SM. However, no research has examined treatment options for older youth with SM. The present study sought to examine effectiveness of an intensive group behavioral treatment (IGBT) for older youth with SM by examining pretreatment to follow-up differences on primary (SM symptoms) and secondary outcomes (self-efficacy and social skills). Sixteen youth, ages 10–17, with a primary diagnosis of SM engaged in a 5-day IGBT. Results indicated statistically significant reductions in parent- and self-reported SM symptoms from pretreatment to follow-up (2 months and 5 months into the following school year), as well as statistically significant improvements in self-reported self-efficacy and social skills from pretreatment to follow-up. These findings provide empirical support for the preliminary effectiveness of IGBT for older youth with SM and reveal information about the unique clinical profile of this subset of the population.
选择性缄默症(SM)是一种焦虑障碍,其特征是无法在社交场合说话,尽管在熟悉的情况下可以轻松地说话(美国精神病学协会,2022)。迄今为止,研究已经证明了认知行为治疗(CBT)模式的有效性,包括每周的CBT和对年幼的SM儿童的强化团体行为治疗。然而,没有研究检查过老年青年SM患者的治疗方案。本研究试图通过检查预处理与随访在主要(SM症状)和次要结果(自我效能感和社交技能)上的差异来检验强化团体行为治疗(IGBT)对老年青年SM的有效性。16名青少年,年龄10-17岁,初步诊断为SM,参加为期5天的IGBT。结果显示,从预处理到随访(2个月和5个月到下一个学年),父母和自我报告的SM症状有统计学意义的减少,从预处理到随访,自我报告的自我效能感和社交技能有统计学意义的改善。这些发现为IGBT对老年青年SM患者的初步有效性提供了实证支持,并揭示了这一人群的独特临床特征。
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引用次数: 0
Feasibility of a Primary Care–Based Program for Supporting Youth Following Traumatic Events: First Approach Skills Training for Trauma (FAST-T) 创伤事件后支持青少年初级保健项目的可行性:创伤第一步技能培训(FAST-T)
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2026-02-01 DOI: 10.1016/j.cbpra.2024.10.003
Nathaniel J. Jungbluth, China R. Bolden, Erin Gonzalez, Isha W. Metzger, Jennifer B. Blossom
Integrated primary care (IPC) offers an opportunity to identify and support youth impacted by trauma. Trauma interventions with strong evidence exist but require adaptation for IPC. The First Approach Skills Training for Trauma (FAST-T) program was developed as a scalable, flexible, brief, stepped-care, cognitive-behavioral approach to supporting trauma-affected youth and families. This paper describes program development and implementation of FAST-T in real-world IPC settings. All FAST-T resources, including modular child, teen, and caregiver workbooks, handouts, training videos, and clinical guides/scripts are provided via hyperlink. Eight behavioral health clinicians (BHCs) from across Washington State were trained in FAST-T and provided de-identified treatment delivery and outcome data from all patients enrolled in FAST-T over 3 months. Posttraumatic stress symptom change and clinician-rated improvement were collected, as were data on treatment components used, number of sessions, and discharge disposition. Clinicians reported on acceptability, appropriateness, feasibility and other implementation outcomes. Acceptability, appropriateness and feasibility were rated by BHCs as favorable with good evidence of uptake in routine care at 6 months posttraining. Nineteen youths received FAST-T and while the sample was underpowered to evaluate clinical outcomes, those with repeat measures of posttraumatic stress showed significant improvement. BHC ratings indicated most patients improved and none worsened during FAST-T. Findings offer preliminary support for addressing childhood trauma impact with flexible, brief programming within IPC.
综合初级保健(IPC)为识别和支持受创伤影响的青年提供了机会。有强有力证据的创伤干预措施存在,但需要适应IPC。创伤第一方法技能培训(FAST-T)项目是一种可扩展的、灵活的、简短的、阶梯式护理的、认知行为的方法,用于支持受创伤影响的青少年和家庭。本文描述了FAST-T在实际IPC设置中的程序开发和实现。所有FAST-T资源,包括模块化儿童,青少年和护理人员工作手册,讲义,培训视频和临床指南/脚本通过超链接提供。来自华盛顿州各地的8名行为健康临床医生(bhc)接受了FAST-T的培训,并提供了所有参加FAST-T治疗超过3个月的患者的治疗交付和结果数据。收集创伤后应激症状的改变和临床评定的改善,以及使用的治疗成分、治疗次数和出院处置的数据。临床医生报告了可接受性、适当性、可行性和其他实施结果。可接受性、适宜性和可行性被BHCs评价为有利的,并且在训练后6个月的常规护理中有良好的证据。19名青少年接受了FAST-T治疗,虽然样本不足以评估临床结果,但那些重复测量创伤后应激的人表现出显著的改善。BHC评分显示,在FAST-T期间,大多数患者得到改善,没有患者恶化。研究结果为通过IPC内灵活、简短的规划解决儿童创伤影响提供了初步支持。
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引用次数: 0
Integration of a Pedometer-Based Physical Activity Intervention with Cognitive Behavioral Therapy for Adults with Chronic Obstructive Lung Disease. 基于计步器的身体活动干预与认知行为治疗对慢性阻塞性肺疾病成人的整合
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-07-18 DOI: 10.1016/j.cbpra.2025.07.001
Patricia M Bamonti, Marilyn L Moy, Grace A Rose, Amy K Silberbogen, Jeffrey A Cully, Erica R Checko, David Coultas, Brent R Schell, Jennifer Moye

Physical activity interventions effectively improve physical activity (i.e., daily step count) and reduce the risk of adverse health outcomes in persons with chronic obstructive pulmonary disease (COPD), but effects on depression and anxiety are poorly understood. Behavioral interventions concurrently targeting both physical activity and mood symptoms are needed in this population. This paper describes acceptability testing and refinement of Step-CBT, a synchronous, video-delivered, pedometer-based physical activity intervention integrated with cognitive behavioral therapy (CBT) to improve step count in individuals with COPD; physical disability and depression and anxiety symptoms are secondary outcomes. Adults (N = 5) with COPD and clinically significant depression and/or anxiety symptoms were enrolled; three completed Step-CBT. During the run-in period (i.e., after consent, before intervention), one participant did not meet eligibility criteria, and one withdrew due to disliking the Fitbit Inspire and preferring to attend to other health conditions. Completers rated high satisfaction with the intervention and virtual modality, and high adherence, with improvements in physical activity and/or depression and/or anxiety. Findings illuminate the complexities, barriers, and facilitators that emerged for each participant suggesting additional testing of the intervention is warranted.

身体活动干预有效地改善了慢性阻塞性肺疾病(COPD)患者的身体活动(即每日步数)并降低了不良健康结果的风险,但对抑郁和焦虑的影响了解甚少。在这一人群中,需要同时针对身体活动和情绪症状的行为干预。本文描述了步进CBT的可接受性测试和改进,步进CBT是一种同步、视频传输、基于计步器的身体活动干预,与认知行为疗法(CBT)相结合,以改善COPD患者的步数;身体残疾、抑郁和焦虑症状是次要后果。纳入患有慢性阻塞性肺病和临床显著抑郁和/或焦虑症状的成人(N = 5);三个完成步进cbt。在磨合期(即同意后,干预前),一名参与者不符合资格标准,一名参与者因不喜欢Fitbit Inspire而退出,更愿意关注其他健康状况。完成者对干预和虚拟模式的满意度很高,并且对身体活动和/或抑郁和/或焦虑的改善有很高的依从性。研究结果阐明了复杂性、障碍和每个参与者出现的促进因素,建议对干预措施进行额外的测试是必要的。
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引用次数: 0
A New Generation of Psychedelic-Assisted Psychotherapy: The Example of Combining MDMA With Trauma-Focused Cognitive-Behavioral Therapy for Posttraumatic Stress Disorder 新一代迷幻辅助心理治疗:将MDMA与创伤性认知行为疗法结合治疗创伤后应激障碍的例子
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-06-03 DOI: 10.1016/j.cbpra.2025.05.001
Barbara O. Rothbaum, Paula P. Schnurr
Posttraumatic Stress Disorder (PTSD) is a treatable condition, with effective psychotherapies and medications offering a range of treatment options for patients. Trauma-focused psychotherapies, such as prolonged exposure and cognitive processing therapy, are recommended as first-line approaches. However, even the best treatments do not work well enough for everyone, indicating a need for enhanced treatment outcomes. While the evidence on how to achieve this remains limited and inconclusive, there is growing interest in exploring novel approaches. In this commentary we focus on how psychedelic substances, particularly MDMA (3,4-methylenedioxymethamphetamine), hold promise for enhancing PTSD mental health treatment outcomes, using MDMA (3,4-methylenedioxymethamphetamine)-assisted cognitive-behavioral therapy (CBT) for PTSD. Recent Phase 3 randomized controlled trials have demonstrated benefits of MDMA-assisted psychotherapy for PTSD, with high response and remission rates. However, challenges exist in implementing this approach due to its time-intensive nature and unique therapy protocol. Combining psychedelics with established trauma-focused psychotherapies presents an intriguing avenue for improving treatment outcomes. Psychedelics may work by enhancing connections and insights, facilitating emotional processing and adaptive coping mechanisms. By incorporating psychedelics into existing cognitive behavioral frameworks, such as prolonged exposure and cognitive processing therapy, it may be possible to achieve synergistic effects and enhance the efficiency of therapy delivery. In conclusion, the evidence supports psychedelic-assisted therapy as a viable option for PTSD treatment, particularly MDMA. Combining psychedelics with CBT holds promise for synergistic treatment effects, improved efficiency, and real-world implementation. Future research should explore various combinations of psychedelics with evidence-based treatments to optimize care for PTSD and other mental health disorders and provide patients with additional therapeutic options.
创伤后应激障碍(PTSD)是一种可治疗的疾病,有效的心理疗法和药物为患者提供了一系列治疗选择。以创伤为重点的心理治疗,如长时间暴露和认知加工治疗,建议作为一线方法。然而,即使是最好的治疗方法也不是对每个人都有效,这表明需要提高治疗效果。虽然关于如何实现这一目标的证据仍然有限且不确定,但探索新方法的兴趣越来越大。在这篇评论中,我们关注迷幻物质,特别是MDMA(3,4-亚甲基二氧基甲基苯丙胺),如何在使用MDMA(3,4-亚甲基二氧基甲基苯丙胺)辅助认知行为疗法(CBT)治疗创伤后应激障碍的过程中提高PTSD心理健康治疗效果。最近的3期随机对照试验证明了mdma辅助心理治疗对创伤后应激障碍的益处,具有高反应和缓解率。然而,由于其时间密集的性质和独特的治疗方案,在实施这种方法时存在挑战。将致幻剂与已建立的以创伤为中心的心理疗法相结合,为改善治疗结果提供了一条有趣的途径。迷幻药可能通过增强联系和洞察力,促进情绪处理和适应性应对机制而起作用。通过将致幻剂纳入现有的认知行为框架,如长时间暴露和认知加工治疗,有可能实现协同效应并提高治疗的效率。总之,证据支持迷幻辅助疗法作为治疗PTSD的可行选择,尤其是MDMA。将迷幻药与认知行为治疗相结合,有望产生协同治疗效果,提高效率,并在现实世界中实施。未来的研究应该探索迷幻药与循证治疗的各种组合,以优化PTSD和其他精神健康障碍的护理,并为患者提供额外的治疗选择。
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引用次数: 0
A Case Study of the METEMP Protocol: Massed Exposure Therapy Enhanced With 3,4-Methylenedioxymethamphetamine (MDMA) for Posttraumatic Stress Disorder METEMP方案的案例研究:3,4-亚甲基二氧基甲基苯丙胺(MDMA)强化的大规模暴露疗法治疗创伤后应激障碍
IF 2.9 3区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-06-03 DOI: 10.1016/j.cbpra.2025.02.001
Jessica L. Maples-Keller, Barbara O. Rothbaum
This case study provides a detailed description of a participant in an open label clinical trial receiving the METEMP intervention, Massed Exposure Therapy Enhanced with 100 mg 3,4-methylenedioxymethamphetamine (MDMA) for posttraumatic stress disorder. After thorough medical and psychiatric screening to ensure eligibility and appropriateness for this treatment, two clinical psychologists treated a 57-year-old woman with PTSD over a 10-day treatment period. An independent rater not involved in treatment conducted a CAPS-5-R at baseline, 1 week, and 1 month following treatment as the primary outcome. Quantitative results suggest significant PTSD symptom reduction (pretreatment CAPS-5-R = 85, 1-week posttreatment = 1, 1-month posttreatment = 1). PCL-5 and PHQ-9 suggest significant decreases in self-reported PTSD (43 at pretreatment to 1 at 1-month posttreatment) and depression (10 at pretreatment to 0 at 1-month posttreatment). We provide specific details on this novel combined treatment and how PE was modified for MDMA administration. The treatment protocol appears feasible and will continue to be tested in this open label pilot trial before subsequent investigation in a randomized controlled trial.
本案例研究详细描述了一名接受METEMP干预的开放标签临床试验参与者的情况,即100mg 3,4-亚甲基二氧基甲基苯丙胺(MDMA)强化的大规模暴露疗法治疗创伤后应激障碍。经过彻底的医学和精神病学筛查,以确保这种治疗的资格和适当性,两位临床心理学家对一位患有创伤后应激障碍的57岁女性进行了为期10天的治疗。一名未参与治疗的独立评分者在基线、治疗后1周和1个月进行CAPS-5-R作为主要结局。定量结果显示PTSD症状明显减轻(治疗前CAPS-5-R = 85,治疗后1周= 1,治疗后1个月= 1)。PCL-5和PHQ-9提示自我报告PTSD(治疗前43人,治疗后1个月为1人)和抑郁(治疗后1个月为10人,治疗后1个月为0人)显著降低。我们提供了这种新型联合治疗的具体细节,以及PE如何被修改为MDMA给药。治疗方案似乎是可行的,在随后的随机对照试验调查之前,将继续在这个开放标签试点试验中进行测试。
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引用次数: 0
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Cognitive and Behavioral Practice
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