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Percutaneous radiofrequency ablation of ovarian cancer metastasis in the spleen: a therapeutic option to consider. 经皮射频消融脾脏中的卵巢癌转移灶:一种值得考虑的治疗方案。
IF 1.3 Q2 Medicine Pub Date : 2024-06-20 DOI: 10.1007/s40477-024-00921-9
Andrea Boccatonda, Paula Antonia Mauloni, Monica Cevenini, Livia Masi, Sofia Maria Bakken, Carla Serra

Splenic metastasis are rare clinical entities developing in less than 1% of all metastatic cancers and usually in the setting of disseminated disease. To date, splenectomy is traditionally the first line therapy in patient with splenic metastasis, however non-surgical therapies have been reported. Here we described the case of a 57-year-old patient with splenic metastasis from ovarian cancer successfully treated by percutaneous radiofrequency ablation. Furthermore, we performed a literature systematic review of the cases of splenic metastases treated by thermal ablation.

在所有转移性癌症中,脾转移是一种罕见的临床实体,发病率不到 1%,而且通常是在疾病扩散的情况下。迄今为止,脾切除术一直是脾转移患者的一线治疗方法,但也有非手术疗法的报道。在此,我们描述了一例 57 岁的卵巢癌脾转移患者通过经皮射频消融术成功治疗的病例。此外,我们还对通过热消融治疗脾转移的病例进行了文献系统回顾。
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引用次数: 0
Assessment of the ulnar nerve stiffness during valgus stress of the elbow using shear wave elastography: an observational cross-sectional study. 利用剪切波弹性成像技术评估肘部外翻受力时尺神经的僵硬程度:一项横断面观察研究。
IF 2 Q2 Medicine Pub Date : 2024-06-20 DOI: 10.1007/s40477-024-00922-8
Issei Noda, Rio Goto, Shunpei Yamashita, Kengo Kawanishi, Masahiro Tsutsumi, Shintarou Kudo

Background: Identification of the relationship between valgus stress in the medial elbow and ulnar nerve strain during maximum external rotation of the shoulder is pivotal for the prevention and management of ulnar neuropathies. In this observational cross-sectional study, we aimed to determine the changes in ulnar nerve stiffness under valgus stress at different nerve entrapment sites.

Methods: Twenty healthy baseball players participated in the study. The stiffness of the ulnar nerve on the throwing side was assessed at two sites, the arcade of Struthers and the Osborne's ligament, at 0°, 60°, and 90° flexion by shear wave elastography using a 10-MHz linear transducer. The arcade of Struthers was defined as the proximal site and the Osborne's ligament as the distal site. Valgus stress was applied to the medial elbow at 0, 30, 50, and 70 N using a Telos stress device, and the stiffness caused by valgus stress was measured.

Results: At all elbow flexion angles, the stiffness of the ulnar nerve under 70 N valgus stress was higher than that under 30 N stress. The stiffness of the ulnar nerve at the proximal site was significantly higher than that at the distal site.

Conclusion: Valgus stress increases ulnar nerve stiffness. In addition, the stiffness of the proximal site increases.

背景:确定肩部最大外旋时肘内侧的外翻应力与尺神经应变之间的关系对于预防和治疗尺神经病至关重要。在这项观察性横断面研究中,我们旨在确定不同神经卡压部位在外翻应力作用下尺神经硬度的变化:方法:20 名健康的棒球运动员参与研究。在屈曲 0°、60° 和 90°时,通过使用 10-MHz 线性传感器进行剪切波弹性成像,评估投掷侧尺神经在 Struthers 弧部和 Osborne 韧带两个部位的硬度。Struthers弧被定义为近端部位,Osborne韧带被定义为远端部位。使用泰洛斯应力装置对肘关节内侧施加0、30、50和70牛顿的外翻应力,并测量外翻应力引起的僵硬度:结果:在所有肘关节屈曲角度下,尺神经在 70 牛顿外翻应力下的僵硬度均高于 30 牛顿应力下的僵硬度。尺神经近端部位的硬度明显高于远端部位:结论:外翻应力会增加尺神经的硬度。结论:外翻应力会增加尺神经的硬度,此外,近端部位的硬度也会增加。
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引用次数: 0
Unusual application of twinkling artifact. 闪烁神器的不寻常应用。
IF 2 Q2 Medicine Pub Date : 2024-06-19 DOI: 10.1007/s40477-023-00861-w
Francesco M Drudi, Roberto Maroncelli, Flavia Angelini, Maurizio Renda, Gianluca Maglia, Michele Bertolotto, Vito Cantisani

Introduction: The aim of this paper is to show how to improve diagnostic accuracy using CDUS and twinkling artifact in patients experiencing discomfort due to the presence of small FBs in the soft tissues not clearly visible at US grayscale examination.

Materials and methods: We enrolled 7 adult patients presenting with small (2-4 mm) superficial FBs located in the subcutaneous and muscle tissues, barely or not detectable on US grayscale. All patients underwent US grayscale and CDUS examinations.

Results: We identified superficial FB with twinkling artifact in all 7 patients. All of these were confirmed to represent foreign bodies after surgical excision.

Conclusion: TA is useful in the evaluation of subcutaneous and muscular FBs and provides information on their location, depth and shape, which is useful if surgical excision is required.

简介:本文旨在说明如何利用 CDUS 和闪烁伪影提高因软组织中存在小 FB(在 US 灰阶检查中无法清晰显示)而感到不适的患者的诊断准确性:我们选取了 7 名成年患者,他们的皮下和肌肉组织中存在小的(2-4 毫米)浅表 FB,在 US 灰阶检查中几乎无法检测到。所有患者均接受了 US 灰阶和 CDUS 检查:结果:我们在所有 7 名患者中都发现了带有闪烁伪影的浅表 FB。结果:我们在 7 例患者中均发现了带有闪烁伪影的浅表 FB,手术切除后证实这些均为异物:结论:TA 可用于评估皮下和肌肉异物,并提供有关其位置、深度和形状的信息,在需要手术切除时非常有用。
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引用次数: 0
Testicular juvenile granulosa cell tumor: a case report. 睾丸幼年颗粒细胞瘤:病例报告。
IF 2 Q2 Medicine Pub Date : 2024-06-16 DOI: 10.1007/s40477-024-00905-9
Michelangelo Baldazzi, Eugenio Rossi, Rocco Minelli, Giuseppe Paviglianiti, Marcello Napolitano, Paolo Romeo, Francesco Galuppi, Anna Olga Di Vincenzo, Laura Greco, Donatella Vivacqua, Eduje Thomas, Luigi Lovato, Mario Lima

The Testicular Juvenile Granulosa Cell Tumor (JGCT) is a rare testicular neoplasm that appears in the first months of life as a painless testicular mass. Following an accurate radiological ultrasound diagnosis, through which the cystic appearance of the lesion is observed, and histological confirmation, showing follicular growth pattern and an immunoreactivity for inhibin, the treatment process involves, when feasible, conservative surgery. We present the case of a 2-months old infant with a bilateral JGCT of the testis and we review the classical findings of the patology.

睾丸幼年颗粒细胞瘤(JGCT)是一种罕见的睾丸肿瘤,在婴儿出生后的头几个月以无痛性睾丸肿块的形式出现。超声放射学诊断准确,可观察到病变的囊性外观,组织学确诊显示滤泡生长模式和抑制素免疫反应,治疗过程包括在可行的情况下进行保守手术。我们介绍了一例 2 个月大的婴儿双侧睾丸 JGCT 病例,并回顾了该病理学的经典发现。
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引用次数: 0
A nephrology trainee can define the fluid status through lung ultrasonography and inferior vena cava measurements in hemodialysis patients: an observational study in a single center. 肾内科实习生可通过肺部超声波检查和下腔静脉测量确定血液透析患者的体液状况:一项在单一中心进行的观察性研究。
IF 2 Q2 Medicine Pub Date : 2024-06-12 DOI: 10.1007/s40477-024-00903-x
Christodoulos Keskinis, Stylianos Panagoutsos, Eleni Soilemezi, Panagiotis Pateinakis, Parthena Kyriklidou, Evangelos Memmos, Dorothea Papadopoulou, Ploumis Passadakis

Aims: The determination of ideal weight in hemodialysis patients remains a common problem. The use of Lung Ultrasound (LUS) is an emerging method of assessing the hydric status of hemodialysis patients. LUS combined with Inferior Vena Cava (IVC) ultrasonography can define the fluid status in hemodialysis patients.

Methods: This study included 68 hemodialysis patients from the Dialysis Unit of Papageorgiou General Hospital in Thessaloniki. The patients underwent lung and IVC ultrasound 30 min before and after the end of the dialysis session by a nephrology trainee. Patients' ideal weight was modified based on daily clinical practice rather than ultrasound findings. The presence of B lines and ultrasound findings of the IVC were evaluated.

Results: The average B line score was 11.53 ± 5.02 before dialysis and became 5.57 ± 3.14 after the session. The average diameter of the IVC was 14.266 ± 0.846 mm before dialysis and 12.328 ± 0.879 mm after the session. The patients were categorized based on the magnitude of overhydration and the findings were evaluated. In addition, findings after the session showed a statistically significant correlation between the b line score and the diameter of the IVC adjusted for the body surface area. (p = 0.009 < 0.05).

Conclusions: A high rate of hyperhydration was detected before the dialysis session (25%). While it is the first study conducted by a nephrology trainee highlighting that it is a feasible technique. Intervention studies should be carried out in the future to draw more precise conclusions.

目的:确定血液透析患者的理想体重仍是一个常见问题。使用肺部超声波(LUS)是评估血液透析患者水分状况的一种新兴方法。LUS 结合下腔静脉(IVC)超声波检查可确定血液透析患者的体液状况:本研究纳入了塞萨洛尼基帕帕吉奥古综合医院透析室的 68 名血液透析患者。在透析疗程结束前后 30 分钟,由一名肾内科见习医师对患者进行肺部和大静脉超声检查。患者的理想体重根据日常临床实践而非超声检查结果进行调整。对 B 线的存在和 IVC 超声波检查结果进行评估:结果:透析前 B 线平均值为 11.53 ± 5.02,透析后 B 线平均值为 5.57 ± 3.14。透析前 IVC 的平均直径为 14.266 ± 0.846 毫米,透析后为 12.328 ± 0.879 毫米。根据过度脱水的程度对患者进行分类,并对结果进行评估。此外,透析后的结果显示,b 线评分与根据体表面积调整后的 IVC 直径之间存在统计学意义上的显著相关性。(p = 0.009 结论:透析前发现的高水化率(25%)。虽然这是肾内科实习生进行的首次研究,但强调了这是一项可行的技术。今后应开展干预研究,以得出更准确的结论。
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引用次数: 0
The importance of ultrasound-guided biopsy: lesson from a case of liver metastasis from uveal melanoma. 超声引导活检的重要性:从一例葡萄膜黑色素瘤肝转移病例中汲取的教训。
IF 2 Q2 Medicine Pub Date : 2024-06-12 DOI: 10.1007/s40477-024-00909-5
Maria Boe, Susanna Vicari, Andrea Boccatonda, Fabio Piscaglia

Melanoma is an extremely aggressive malignant neoplasm. Uveal melanoma is the most common primary intraocular malignancy in adults, representing 3-5% of all melanomas. Liver metastases can be clinically detected in 10-20% of patients with metastatic disease from cutaneous melanoma. However, while liver is typically not the first site of disease spread in cutaneous melanoma, ocular melanoma has been showed to primarily metastasize from the eye to the liver; indeed, liver metastases are detected in approximately 87% of patients with metastatic uveal melanoma. Therefore, liver metastasis can be challenging to identify in early stages, thus being essentially asymptomatic until the disease has advanced. Here we report the case of a patient who came to our ultrasound unit reporting a large liver mass. Both contrast-enhanced abdominal computed tomography and magnetic resonance imaging did not establish a definitive diagnosis. The final diagnosis was made only through an ultrasound-guided biopsy of the mass, thus revealing a uveal melanoma metastasis. This is followed by a review of the literature on imaging follow-up of patients with melanoma.

黑色素瘤是一种侵袭性极强的恶性肿瘤。葡萄膜黑色素瘤是成人最常见的原发性眼内恶性肿瘤,占所有黑色素瘤的 3-5%。临床上,10%-20% 的皮肤黑色素瘤转移患者可发现肝转移。然而,虽然肝脏通常不是皮肤黑色素瘤疾病扩散的第一个部位,但眼部黑色素瘤已被证明主要是从眼部转移到肝脏;事实上,在大约87%的转移性葡萄膜黑色素瘤患者中都能检测到肝脏转移。因此,肝转移在早期阶段很难被发现,因此在病情恶化之前基本上没有症状。在此,我们报告了一例前来超声科就诊的患者的病例。造影剂增强腹部计算机断层扫描和磁共振成像均未能明确诊断。通过超声引导下的肿块活检,最终确诊为葡萄膜黑色素瘤转移。接下来是对黑色素瘤患者影像学随访文献的回顾。
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引用次数: 0
Increasing utilization of contrast-enhanced ultrasound during abdominal biopsies: impact of an educational training program. 提高腹部活组织检查中造影剂增强超声波的使用率:教育培训计划的影响。
IF 2 Q2 Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-08 DOI: 10.1007/s40477-023-00862-9
Lisa M Ho, James Ronald, Benjamin Wildman-Tobriner

Rational and objectives: To increase utilization of contrast-enhanced ultrasound (CEUS) during ultrasound-guided targeted liver biopsies.

Material and methods: Two educational training interventions performed to increase use of CEUS. First, 14 radiologists (fellowship-trained in Abdominal Imaging) given didactic teaching and case presentations on the use of CEUS. Second, hands-on teaching on how to use CEUS provided to the same group. To determine the efficacy of these two interventions, radiologists completed anonymous surveys to determine the level of understanding and acceptability of using CEUS before and 6 months after CEUS training. In addition, the percentage of CEUS assisted liver biopsies was compared for the 6 months before and 6 months after the training.

Results: Pre-training survey completed by 11 radiologists and post-training survey completed by 9 radiologists. Before training, 11% survey responders use CEUS routinely, whereas 89% never or rarely used it. After training, 54% of respondents were new users and 100% reported they planned to use CEUS in the future. Unfamiliarity (71%) was the main reason for not using it. After training, 25% reported lack of comfort with using CEUS as the main reason for not using CEUS. During six months before training, CEUS was administered in 6% (10/172) of targeted liver biopsies. Six months after training, CEUS was used nearly twice as often (10%, 16/160, P = 0.09, 1-sided Boschloo test). The number of radiologists using CEUS increased to 57% (8/14) after training compared to 20% (3/14, P = 0.03, 1-sided Boschloo) before training.

Conclusion: Educational training intervention increases use of CEUS during ultrasound-guided targeted liver biopsies.

理论依据和目标:在超声引导下进行肝脏靶向活检时提高造影剂增强超声(CEUS)的使用率:为提高CEUS的使用率,进行了两次教育培训干预。首先,14 名放射科医生(接受过腹部成像专业的研究员培训)就 CEUS 的使用进行了说教和病例展示。第二,向同组人员提供如何使用 CEUS 的实践教学。为确定这两项干预措施的效果,放射科医生填写了匿名调查问卷,以确定在 CEUS 培训前和培训 6 个月后对使用 CEUS 的理解和接受程度。此外,还比较了培训前 6 个月和培训后 6 个月 CEUS 辅助肝活检的百分比:11名放射科医生完成了培训前调查,9名放射科医生完成了培训后调查。培训前,11% 的受访者常规使用 CEUS,而 89% 的受访者从未或很少使用 CEUS。培训后,54% 的受访者成为新用户,100% 的受访者表示他们计划将来使用 CEUS。不熟悉(71%)是不使用的主要原因。培训后,25% 的受访者表示不熟悉 CEUS 是不使用 CEUS 的主要原因。在培训前的六个月中,有6%(10/172)的肝脏活组织检查使用了CEUS。培训六个月后,CEUS的使用率几乎是培训前的两倍(10%,16/160,P = 0.09,单侧Boschloo检验)。培训后使用CEUS的放射科医生增至57%(8/14),而培训前为20%(3/14,P = 0.03,单侧Boschloo检验):结论:教育培训干预提高了在超声引导下进行肝脏靶向活检时 CEUS 的使用率。
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引用次数: 0
Color Doppler ultrasound and real-time elastography in patients with hypothyroidism for the prediction of levothyroxine replacement: a cross-sectional study of 338 patients. 彩色多普勒超声和实时弹性成像在甲状腺功能减退症患者中用于预测左甲状腺素替代治疗的效果:一项对 338 名患者进行的横断面研究。
IF 2 Q2 Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI: 10.1007/s40477-024-00876-x
Nikolaos Angelopoulos, Dimitrios G Goulis, Ioannis Chrisogonidis, Sarantis Livadas, Ioannis Iakovou

Aims: While hormonal assays are commonly used for thyroid function assessment, Doppler sonography provides valuable information on vascularization and blood flow. This study aimed to examine the potential associations between Doppler parameters and clinical characteristics of hypothyroid patients, such as the autoimmune nature of the disease and adequacy of LT4 replacement.

Methods: A total of 338 patients with hypothyroidism, primarily caused by autoimmune thyroiditis (AT), were enrolled in this study. Exclusion criteria comprised specific medical conditions, medication history, and nodular abnormalities of the thyroid gland. Patient demographics (age, sex, BMI), treatment parameters (LT4 daily dose), and thyroid hormone levels (TSH, fT4) were recorded.

Results: Among the enrolled patients, 85.2% had autoimmune thyroiditis. Suboptimal levothyroxine (LT4) replacement was observed in 20.1% of patients at the time of enrollment. Patients with autoimmune thyroiditis had increased elastography ratios compared to those without autoimmune disease and present a positive association of elastography ratios with vascularity. In patients without autoimmune thyroiditis, those with suboptimal LT4 replacement had lower total thyroid volume. Patients with suboptimal LT4 replacement had higher peak systolic velocity (PSV) and end-diastolic velocity (EDV) in the inferior thyroid artery and lower resistive index (RI). The severity of hypothyroidism, as indicated by LT4 dose/body mass index (BMI), was negatively correlated with thyroid volume and EDV values of superior and inferior thyroid arteries. PSV of the inferior thyroid artery can predict suboptimal LT4 replacement (sensitivity 81.8%, specificity 42%).

Conclusions: In situations where obtaining blood tests may be challenging, utilizing color Doppler ultrasound can serve as an alternative method to assess treatment responses and identify patients who require further hormonal examinations.

目的:虽然激素测定常用于甲状腺功能评估,但多普勒超声检查可提供有关血管化和血流的宝贵信息。本研究旨在探讨多普勒参数与甲减患者临床特征(如疾病的自身免疫性和LT4替代的充分性)之间的潜在关联:本研究共纳入338名主要由自身免疫性甲状腺炎(AT)引起的甲减患者。排除标准包括特殊病症、用药史和甲状腺结节异常。研究记录了患者的人口统计学特征(年龄、性别、体重指数)、治疗参数(LT4每日剂量)和甲状腺激素水平(促甲状腺激素、fT4):在登记的患者中,85.2%患有自身免疫性甲状腺炎。20.1%的患者在入组时发现左甲状腺素(LT4)补充不足。与无自身免疫性疾病的患者相比,自身免疫性甲状腺炎患者的弹性成像比值增大,弹性成像比值与血管性呈正相关。在无自身免疫性甲状腺炎的患者中,LT4补充不足的患者甲状腺总容积较低。LT4补充不足的患者甲状腺下动脉的收缩峰值速度(PSV)和舒张末期速度(EDV)较高,阻力指数(RI)较低。以LT4剂量/体重指数(BMI)表示的甲状腺功能减退症严重程度与甲状腺容积和甲状腺上下动脉的EDV值呈负相关。甲状腺下动脉的PSV值可以预测LT4替代效果不理想的情况(灵敏度为81.8%,特异度为42%):结论:在抽血化验具有挑战性的情况下,利用彩色多普勒超声可作为一种替代方法来评估治疗反应,并确定需要进一步激素检查的患者。
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引用次数: 0
Gastroschisis: embriology, pathogenesis, risk factors, prognosis, and ultrasonographic markers for adverse neonatal outcomes. 胃畸形:栓塞学、发病机理、危险因素、预后和新生儿不良结局的超声标记。
IF 2 Q2 Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-29 DOI: 10.1007/s40477-024-00887-8
Thalita Diógenes Muniz, Liliam Cristine Rolo, Edward Araujo Júnior

Gastroschisis is the most common congenital defect of the abdominal wall, typically located to the right of the umbilical cord, through which the intestinal loops and viscera exit without being covered by the amniotic membrane. Despite the known risk factors for gastroschisis, there is no consensus on the cause of this malformation. Prenatal ultrasound is useful for diagnosis, prognostic prediction (ultrasonographic markers) and appropriate monitoring of fetal vitality. Survival rate of children with gastroschisis is more than 95% in developed countries; however, complex gastroschisis requires multiple neonatal interventions and is associated with adverse perinatal outcomes. In this article, we conducted a narrative review including embryology, pathogenesis, risk factors, and ultrasonographic markers for adverse neonatal outcomes in fetuses with gastroschisis. Prenatal risk stratification of gastroschisis helps to better counsel parents, predict complications, and prepare the multidisciplinary team to intervene appropriately and improve postnatal outcomes.

胃裂是最常见的先天性腹壁缺损,通常位于脐带右侧,肠襻和内脏从这里排出,而不被羊膜覆盖。尽管胃螺裂的风险因素众所周知,但对这种畸形的病因还没有达成共识。产前超声检查有助于诊断、预后预测(超声标记)和适当监测胎儿的活力。在发达国家,胃畸形患儿的存活率超过 95%;然而,复杂性胃畸形需要多种新生儿干预措施,并与不良围产期结局相关。在本文中,我们对患有胃裂的胎儿的胚胎学、发病机制、风险因素和新生儿不良结局的超声标记进行了叙述性综述。胃裂的产前风险分层有助于更好地为父母提供咨询、预测并发症,并为多学科团队进行适当干预和改善产后预后做好准备。
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引用次数: 0
Global use of ultrasound in newborn vascular access: RA. CE. VA: implantation and management of complications. 超声波在新生儿血管通路中的全球应用:RA.CE。VA:植入和并发症处理。
IF 2 Q2 Medicine Pub Date : 2024-06-01 Epub Date: 2023-09-01 DOI: 10.1007/s40477-023-00813-4
Ferdinando Spagnuolo

The use of ultrasound is advantageous in many respects: pre-procedural vein selection, real-time venipuncture, tip navigation (to verify guidewire or catheter progression) and post-procedural tip location, detection of early (hematoma, pneumothorax, hemothorax) and late complications (cardiac tamponade, fibroblastic sleeve, thrombosis).Such assessment is best performed using a systematic and standardized approach, as the Rapid Central Vein Assessment, described in this study for neonates too.

使用超声波在很多方面都有优势:术前静脉选择、实时静脉穿刺、尖端导航(验证导丝或导管的进展)和术后尖端定位、早期(血肿、气胸、血气胸)和晚期并发症(心脏填塞、纤维套管、血栓)的检测。这种评估最好采用系统化和标准化的方法,如本研究中针对新生儿的快速中央静脉评估。
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引用次数: 0
期刊
Journal of Ultrasound
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