Jie Sun, Ping-ping Zhang, Kun Wang, Miao Xu, Jing Sun, Li Li
Background The clinical application of the innovative instantaneous elasticity and fat attenuation measurement technology, Hepatus, is currently in the evaluation stage. This study aimed to compare the detection performance of Fibroscan and Hepatus in patients with metabolic dysregulation who are "at-risk" for non-alcoholic fatty liver disease (NAFLD).Methods Between January 2021 and April 2021, 149 patients were enrolled in this study. Clinical data were collected, and all patients underwent both Fibroscan and Hepatus assessments to determine liver stiffness measurement (LSM) and attenuation parameters. The correlation between the results obtained from the two transient elastography (TE) devices was analyzed. Receiver operating characteristic curves (ROC) were constructed to compare the diagnostic value of Fibroscan and Hepatus for Hepatic Steatosis Index (HSI)-based NAFLD.Results The detection success rate of Hepatus (100.0%) was higher than that of Fibroscan (96.0%). LSM (r = 0.663, P0.05) and attenuation parameters (r = 0.778, P0.05) obtained by Fibroscan and Hepatus were significantly correlated. Hepatus tended to produce a higher LSM (Hepatus vs. Fibroscan: 6.04 vs. 5.66 kPa, P=0.016) but a lower attenuation parameter than Fibroscan (Hepatus vs. Fibroscan: 264 vs. 277 dB/m, P0.001). The area under the ROC curve for detecting HSI-based NAFLD was 0.811 for Fibroscan and 0.832 for Hepatus.Conclusion Measurements obtained by Fibroscan and Hepatus are strongly correlated, and the diagnostic value of the two TE devices is comparable in detecting HSI-based NAFLD. Hepatus offer a potential TE alternative in NAFLD examination.
背景 创新性瞬时弹性和脂肪衰减测量技术 Hepatus 的临床应用目前正处于评估阶段。本研究旨在比较 Fibroscan 和 Hepatus 对代谢失调的非酒精性脂肪肝（NAFLD）"高危 "患者的检测性能。收集了临床数据，所有患者都接受了 Fibroscan 和 Hepatus 评估，以确定肝脏硬度测量（LSM）和衰减参数。研究分析了两种瞬态弹性成像（TE）设备得出的结果之间的相关性。结果 Hepatus 的检测成功率（100.0%）高于 Fibroscan（96.0%）。Fibroscan和Hepatus获得的LSM（r = 0.663，P0.05）和衰减参数（r = 0.778，P0.05）显著相关。Hepatus 产生的 LSM 往往比 Fibroscan 高（Hepatus vs. Fibroscan：6.04 vs. 5.66 kPa，P=0.016），但衰减参数比 Fibroscan 低（Hepatus vs. Fibroscan：264 vs. 277 dB/m，P0.001）。结论 Fibroscan 和 Hepatus 的测量结果具有很强的相关性，两种 TE 设备在检测基于 HSI 的 NAFLD 方面的诊断价值相当。Hepatus为非酒精性脂肪肝检查提供了一种潜在的TE替代方法。
{"title":"Comparation between Fibroscan and Hepatus for detecting NAFLD in patients with metabolic dysregulation","authors":"Jie Sun, Ping-ping Zhang, Kun Wang, Miao Xu, Jing Sun, Li Li","doi":"10.24871/251202411-20","DOIUrl":"https://doi.org/10.24871/251202411-20","url":null,"abstract":"Background The clinical application of the innovative instantaneous elasticity and fat attenuation measurement technology, Hepatus, is currently in the evaluation stage. This study aimed to compare the detection performance of Fibroscan and Hepatus in patients with metabolic dysregulation who are \"at-risk\" for non-alcoholic fatty liver disease (NAFLD).Methods Between January 2021 and April 2021, 149 patients were enrolled in this study. Clinical data were collected, and all patients underwent both Fibroscan and Hepatus assessments to determine liver stiffness measurement (LSM) and attenuation parameters. The correlation between the results obtained from the two transient elastography (TE) devices was analyzed. Receiver operating characteristic curves (ROC) were constructed to compare the diagnostic value of Fibroscan and Hepatus for Hepatic Steatosis Index (HSI)-based NAFLD.Results The detection success rate of Hepatus (100.0%) was higher than that of Fibroscan (96.0%). LSM (r = 0.663, P0.05) and attenuation parameters (r = 0.778, P0.05) obtained by Fibroscan and Hepatus were significantly correlated. Hepatus tended to produce a higher LSM (Hepatus vs. Fibroscan: 6.04 vs. 5.66 kPa, P=0.016) but a lower attenuation parameter than Fibroscan (Hepatus vs. Fibroscan: 264 vs. 277 dB/m, P0.001). The area under the ROC curve for detecting HSI-based NAFLD was 0.811 for Fibroscan and 0.832 for Hepatus.Conclusion Measurements obtained by Fibroscan and Hepatus are strongly correlated, and the diagnostic value of the two TE devices is comparable in detecting HSI-based NAFLD. Hepatus offer a potential TE alternative in NAFLD examination.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic liver diseases continue to face challenges in prognosis, treatment selection, disease mechanisms, screening, and therapeutic optimization. Promising innovations could address these gaps through data integration and novel analytic approaches.Main Body: MAPS-CRAFITY integrating clinical variables, AFP, and CT/MRI findings, and transformer modeling of RFA data improve HCC outcome prediction to guide management. Analyses revealing IL21R as a PBC susceptibility gene and implicating dysfunctional VWF processing in portal hypertension deliver mechanistic insights. Quantifying childhood MAFLD informs screening needs, while supporting use of G6PD deficient liver donors enables transplantation access expansion through risk stratification. Updating Baveno criteria enhances PBC prognosis, and an HCC prognostic score identifies optimal RFA candidates to maximize treatment efficacy.Conclusion: Recent research leverages diverse data types, genetics, imaging, and machine learning to develop integrated predictive systems that allow more personalized therapy selection. Elucidating molecular pathways provides therapeutic targets and prognostic biomarkers. Evidence-based screening and risk models facilitate delivering tailored interventions. Optimization of current modalities through prognostic validation and patient selection improves real-world effectiveness. Multifaceted modern research approaches promise to address unmet needs and transform hepatology care.
{"title":"Transforming Screening, Risk Stratification, and Treatment Optimization in Chronic Liver Disease Through Data Science and translational Innovation","authors":"T. Addissouky","doi":"10.24871/251202453-62","DOIUrl":"https://doi.org/10.24871/251202453-62","url":null,"abstract":"Background: Chronic liver diseases continue to face challenges in prognosis, treatment selection, disease mechanisms, screening, and therapeutic optimization. Promising innovations could address these gaps through data integration and novel analytic approaches.Main Body: MAPS-CRAFITY integrating clinical variables, AFP, and CT/MRI findings, and transformer modeling of RFA data improve HCC outcome prediction to guide management. Analyses revealing IL21R as a PBC susceptibility gene and implicating dysfunctional VWF processing in portal hypertension deliver mechanistic insights. Quantifying childhood MAFLD informs screening needs, while supporting use of G6PD deficient liver donors enables transplantation access expansion through risk stratification. Updating Baveno criteria enhances PBC prognosis, and an HCC prognostic score identifies optimal RFA candidates to maximize treatment efficacy.Conclusion: Recent research leverages diverse data types, genetics, imaging, and machine learning to develop integrated predictive systems that allow more personalized therapy selection. Elucidating molecular pathways provides therapeutic targets and prognostic biomarkers. Evidence-based screening and risk models facilitate delivering tailored interventions. Optimization of current modalities through prognostic validation and patient selection improves real-world effectiveness. Multifaceted modern research approaches promise to address unmet needs and transform hepatology care.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anxiety is a psychological condition characterized by excessive fear and worry that occurs continuously and is difficult to control. Anxiety play a significant role in causing dyspepsia through the Brain-Gut Axis mechanism. Although, there are many cases of anxiety and dyspepsia in Indonesia, there is still a lack of research on the relationship between anxiety and dyspepsia in Indonesia, especially in the clinic. Therefore, this study aimed to determine the relationship between anxiety and dyspepsia among outpatients at Atma Jaya Hospital.Method: This cross-sectional study was conducted on outpatients at Atma Jaya Hospital to investigate the relationship between anxiety and dyspepsia. The demographic and patient characteristic data, including gender, age, highest level of education, and habits, such as eating spicy food, drinking coffee, alcohol consumption, smoking, and NSAID used were collected. The GAD-7 and SF-LDQ questionnaires, which have been validated in Indonesian, were used in this study. Spearman correlation test was used to analyze the data to find the relationship between anxiety and dyspepsia.Results: This study obtained 158 participants. The age range of participants who experienced dyspepsia the most is 19-44 years(77.53%). The majority of those who experienced dyspepsia are female (79.12%). The highest education level of the participants who experienced dyspepsia is a Master’s degree (100%). Participants who consumed spicy food accounted for 61.39% while 54.43% consumed coffee, 6.96% consumed alcohol, 12.66% smoked, and 1.90% used NSAIDs. Additionally, 105 participants (66.46%) experienced both anxiety and dyspepsia. The Spearman correlation test results showed a significant relationship between anxiety and dyspepsia (p-value = 0.000) and a moderate correlation (rs = 0.450). Conclusion: There is a moderate correlation between anxiety and dyspepsia. Keywords: Anxiety, Dyspepsia, GAD-7, Heartburn, SF-LDQ.
{"title":"Association between Anxiety and Dyspepsia among Outpatients at Atma Jaya Hospital","authors":"Samantha Yaffa Heryadi","doi":"10.24871/251202421-26","DOIUrl":"https://doi.org/10.24871/251202421-26","url":null,"abstract":"Background: Anxiety is a psychological condition characterized by excessive fear and worry that occurs continuously and is difficult to control. Anxiety play a significant role in causing dyspepsia through the Brain-Gut Axis mechanism. Although, there are many cases of anxiety and dyspepsia in Indonesia, there is still a lack of research on the relationship between anxiety and dyspepsia in Indonesia, especially in the clinic. Therefore, this study aimed to determine the relationship between anxiety and dyspepsia among outpatients at Atma Jaya Hospital.Method: This cross-sectional study was conducted on outpatients at Atma Jaya Hospital to investigate the relationship between anxiety and dyspepsia. The demographic and patient characteristic data, including gender, age, highest level of education, and habits, such as eating spicy food, drinking coffee, alcohol consumption, smoking, and NSAID used were collected. The GAD-7 and SF-LDQ questionnaires, which have been validated in Indonesian, were used in this study. Spearman correlation test was used to analyze the data to find the relationship between anxiety and dyspepsia.Results: This study obtained 158 participants. The age range of participants who experienced dyspepsia the most is 19-44 years(77.53%). The majority of those who experienced dyspepsia are female (79.12%). The highest education level of the participants who experienced dyspepsia is a Master’s degree (100%). Participants who consumed spicy food accounted for 61.39% while 54.43% consumed coffee, 6.96% consumed alcohol, 12.66% smoked, and 1.90% used NSAIDs. Additionally, 105 participants (66.46%) experienced both anxiety and dyspepsia. The Spearman correlation test results showed a significant relationship between anxiety and dyspepsia (p-value = 0.000) and a moderate correlation (rs = 0.450). Conclusion: There is a moderate correlation between anxiety and dyspepsia. Keywords: Anxiety, Dyspepsia, GAD-7, Heartburn, SF-LDQ.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cokorde Istri Yuliandari Krisnawardani Kumbara, I. Wibawa, I. G. R. Widiana
Introduction: The psychometric hepatic encephalopathy score (PHES) is a tool that can be considered as a gold standard for detecting minimal hepatic encephalopathy (MHE) in liver cirrhosis patients. The PHES must be standardized based on the local healthy population before it can be used. The purpose of this study is to standardize the PHES with Indonesian local populations and set the cutoff point of PHES so it can be used to detect MHE in liver cirrhosis patients.Methods: PHES were administered to all enrolled subjects, which are healthy subjects and cirrhosis without overt encephalopathy subjects. The PHES consists of 5 psychometric tests. The influencing factors of PHES were assessed, and equations were developed to predict the expected result of each test. Diagnosis of MHE was built upon the deviation from the normal range value of PHES.Results: In total, 236 subjects participated in this research. The influencing factors of PHES of this study were age and education years. With the cutoff point of PHES less than -4, the prevalence of MHE was 37.7%, of which 7.6%, 50%, and 50% had Child-Turcotte-Pugh (CTP) grade A, B, and C respectively.Conclusions: The standardized version of PHES can be used to diagnose MHE in Indonesian liver cirrhosis patients. The PHES in this study were affected by age and education years. MHE was diagnosed if the PHES was less than -4. The incidence of MHE was found to increase along with the increase of the liver disease severity
{"title":"The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient","authors":"Cokorde Istri Yuliandari Krisnawardani Kumbara, I. Wibawa, I. G. R. Widiana","doi":"10.24871/251202440-46","DOIUrl":"https://doi.org/10.24871/251202440-46","url":null,"abstract":"Introduction: The psychometric hepatic encephalopathy score (PHES) is a tool that can be considered as a gold standard for detecting minimal hepatic encephalopathy (MHE) in liver cirrhosis patients. The PHES must be standardized based on the local healthy population before it can be used. The purpose of this study is to standardize the PHES with Indonesian local populations and set the cutoff point of PHES so it can be used to detect MHE in liver cirrhosis patients.Methods: PHES were administered to all enrolled subjects, which are healthy subjects and cirrhosis without overt encephalopathy subjects. The PHES consists of 5 psychometric tests. The influencing factors of PHES were assessed, and equations were developed to predict the expected result of each test. Diagnosis of MHE was built upon the deviation from the normal range value of PHES.Results: In total, 236 subjects participated in this research. The influencing factors of PHES of this study were age and education years. With the cutoff point of PHES less than -4, the prevalence of MHE was 37.7%, of which 7.6%, 50%, and 50% had Child-Turcotte-Pugh (CTP) grade A, B, and C respectively.Conclusions: The standardized version of PHES can be used to diagnose MHE in Indonesian liver cirrhosis patients. The PHES in this study were affected by age and education years. MHE was diagnosed if the PHES was less than -4. The incidence of MHE was found to increase along with the increase of the liver disease severity","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"16 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Infantile colic is a functional gastrointestinal disorder (GSCF) found in 20-30% of infants aged 5 months which is characterized by recurrent prolonged periods of infant irritability, fussing, or crying without obvious cause and cannot be prevented or resolved by parents. Infantile colic is often associated with higher mothers depression and lower quality of life. Mothers' knowledge and behavior of infantile colic varies greatly. This research to investigate the knowledge and behavior of Indonesian mothers regarding infantile colic and related factorMethods: A cross-sectional analytic observational study with the target of 100 mothers with babies aged 0-12 months was performed using an electronic questionnaire in Google forms. The questionnaire consists of multiple-choice questions regarding the mothers' knowledge and behavioral to infantile colic.Results: As many as 82% of mothers understand that infantile colic as recurrent prolonged periods of crying that occur without obvious cause and cannot be prevented or resolved by parents, however only 12% of mothers know that most infantile colic will disappear by the age of 5 months. Forty percent mothers had babies with infantile colic; 97.5% of them were worried about their baby's condition and 7.5% of the mothers gave them medication. There was no significant difference between mothers' age and number of children with inadequate mother-infant interaction (P = 0.770 and P = 0.647)Conclusion: The knowledge and behavior of mothers in Indonesia regarding infantile colic is quite good, however parental reassurance still needs to be improved, especially to reduce maternal anxiety.
{"title":"Evaluation of the Knowledge and behavior of Indonesian Mothers About Infantile Colic","authors":"Badriul Hegar","doi":"10.24871/251202434-39","DOIUrl":"https://doi.org/10.24871/251202434-39","url":null,"abstract":"Introduction: Infantile colic is a functional gastrointestinal disorder (GSCF) found in 20-30% of infants aged 5 months which is characterized by recurrent prolonged periods of infant irritability, fussing, or crying without obvious cause and cannot be prevented or resolved by parents. Infantile colic is often associated with higher mothers depression and lower quality of life. Mothers' knowledge and behavior of infantile colic varies greatly. This research to investigate the knowledge and behavior of Indonesian mothers regarding infantile colic and related factorMethods: A cross-sectional analytic observational study with the target of 100 mothers with babies aged 0-12 months was performed using an electronic questionnaire in Google forms. The questionnaire consists of multiple-choice questions regarding the mothers' knowledge and behavioral to infantile colic.Results: As many as 82% of mothers understand that infantile colic as recurrent prolonged periods of crying that occur without obvious cause and cannot be prevented or resolved by parents, however only 12% of mothers know that most infantile colic will disappear by the age of 5 months. Forty percent mothers had babies with infantile colic; 97.5% of them were worried about their baby's condition and 7.5% of the mothers gave them medication. There was no significant difference between mothers' age and number of children with inadequate mother-infant interaction (P = 0.770 and P = 0.647)Conclusion: The knowledge and behavior of mothers in Indonesia regarding infantile colic is quite good, however parental reassurance still needs to be improved, especially to reduce maternal anxiety.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"32 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent inflammation of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn’s disease (CD). While the current global incidence of IBD exceeds 0.3% in Western nations, Indonesia reports a comparatively lower prevalence however with projections indicate a potential rise in incidence from 2020 to 2050. Hepatobiliary manifestation is one of the most common extraintestinal manifestations of IBD. Some of the liver disease associated with IBD had similar background immune response, inflammatory reaction, similar risk factor, or due to the treatment of IBD. Primary sclerosing cholangitis (PSC) has close association with IBD and both affect the prognostic and disease progression of each other. Non-alcoholic fatty liver disease (NAFLD) shares common metabolic risk factors. Several drugs used as the treatment of IBD might cause hepatic injury especially due to the long treatment duration of IBD. Hepatitis B reactivation is another concerning event found after prolonged used of immunosuppressive drugs of IBD. Therefore, close monitoring of liver function test periodically is a mandatory test to screen liver disease in IBD patients. Keyword: Inflammatory bowel disease, liver disease, autoimmune hepatitis, drug-induced liver injury
{"title":"Liver Disease Associated with Inflammatory Bowel Disease","authors":"Juferdy Kurniawan, Refael Alfa Budiman","doi":"10.24871/251202471-75","DOIUrl":"https://doi.org/10.24871/251202471-75","url":null,"abstract":"Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent inflammation of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn’s disease (CD). While the current global incidence of IBD exceeds 0.3% in Western nations, Indonesia reports a comparatively lower prevalence however with projections indicate a potential rise in incidence from 2020 to 2050. Hepatobiliary manifestation is one of the most common extraintestinal manifestations of IBD. Some of the liver disease associated with IBD had similar background immune response, inflammatory reaction, similar risk factor, or due to the treatment of IBD. Primary sclerosing cholangitis (PSC) has close association with IBD and both affect the prognostic and disease progression of each other. Non-alcoholic fatty liver disease (NAFLD) shares common metabolic risk factors. Several drugs used as the treatment of IBD might cause hepatic injury especially due to the long treatment duration of IBD. Hepatitis B reactivation is another concerning event found after prolonged used of immunosuppressive drugs of IBD. Therefore, close monitoring of liver function test periodically is a mandatory test to screen liver disease in IBD patients. Keyword: Inflammatory bowel disease, liver disease, autoimmune hepatitis, drug-induced liver injury","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"34 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: To explore the effects of perioperative probiotics or synbiotics supplementation on postoperative in patients undergoing abdominal surgery.Method: A literature search was conducted on four databases, PubMed, Cochrane, ProQuest, and Scopus, by using MeSH Term. The article selection process was undertaken by screening the titles or abstracts, reviewing the full texts, and determining their compliance with the inclusion and exclusion criteria. Two systematic review/meta-analysis of randomized controlled trial were critically appraised for validity, importance, and applicability.Results: Perioperative probiotics or synbiotics supplementation may contribute to gastrointestinal function recovery, including reducing postoperative ileus in gastrointestinal cancer. Supplementation of probiotics or synbiotics reduced overall postoperative complications in patients undergoing colorectal cancer surgery and did not cause any side effects. However, the administration of probiotics or synbiotics was not associated with the incidence of postoperative ileus.Conclusion: Perioperative probiotics or synbiotics supplementation can be considered in promoting postoperative gastrointestinal function in abdominal surgery. However, their effect on reducing the incidence of postoperative ileus is still inconsistent.
{"title":"The Effect of Perioperative Probiotics or Synbiotics on Postoperative Ileus in Patients Undergoing Abdominal Surgery: An Evidence-based Case Report","authors":"Helena Fabiani, Wiji Lestari","doi":"10.24871/251202476-82","DOIUrl":"https://doi.org/10.24871/251202476-82","url":null,"abstract":"Aims: To explore the effects of perioperative probiotics or synbiotics supplementation on postoperative in patients undergoing abdominal surgery.Method: A literature search was conducted on four databases, PubMed, Cochrane, ProQuest, and Scopus, by using MeSH Term. The article selection process was undertaken by screening the titles or abstracts, reviewing the full texts, and determining their compliance with the inclusion and exclusion criteria. Two systematic review/meta-analysis of randomized controlled trial were critically appraised for validity, importance, and applicability.Results: Perioperative probiotics or synbiotics supplementation may contribute to gastrointestinal function recovery, including reducing postoperative ileus in gastrointestinal cancer. Supplementation of probiotics or synbiotics reduced overall postoperative complications in patients undergoing colorectal cancer surgery and did not cause any side effects. However, the administration of probiotics or synbiotics was not associated with the incidence of postoperative ileus.Conclusion: Perioperative probiotics or synbiotics supplementation can be considered in promoting postoperative gastrointestinal function in abdominal surgery. However, their effect on reducing the incidence of postoperative ileus is still inconsistent.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"46 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of Minimal Hepatic Encephalopathy: Validation of Indonesian Norms for Psychometric Hepatic Encephalopathy Score","authors":"S. H. Nababan","doi":"10.24871/25120241","DOIUrl":"https://doi.org/10.24871/25120241","url":null,"abstract":"","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"41 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Nyoman Gita Kharisma Dewi, Ni Luh Putu Yunia Dewi, Putu Itta Sandi Lesmana Dewi, K. M. N. Pamungkas, D. A. Sindhughosa, I. K. Mariadi
BackgroundCirrhosis of the liver is a final condition of all chronic liver diseases. Liver cirrhosis is the leading cause of increasing morbidity and mortality in adults worldwide. Systemic inflammation has been suggested to play an important role in causing progressive liver damage and is one of the leading causes of compensated and decompensated liver cirrhosis.Aim of StudyEvaluate the correlation of neutrophil-lymphocyte ratio (NLR), albumin-bilirubin ratio (ABR), albumin-bilirubin score (ALBI), aspartate aminotransferase to platelet ratio (APRI), albumin-creatinine ratio (ACR), lymphocyte-monocyte ratio (LMR), de ritis ratio to the severity of liver cirrhosis as assessed by CTP score and MELD score. In addition, this study also evaluated the diagnostic ability of NLR, ABR, ALBI, APRI, ACR, LMR, de ritis ratio, and CTP and MELD scores in predicting decompensated liver cirrhosis.MethodWe conducted a cross-sectional study involving patients diagnosed with liver cirrhosis at Prof DR IGNG Ngoerah General Hospital. All patients were diagnosed based on clinical history, physical examination, and investigations. This study enrolled 96 cirrhotic patients regardless of etiology. Laboratory examination results recorded platelets, neutrophils, lymphocytes, monocytes, AST, ALT, albumin, and creatinine. Then NLR, ACR, APRI, LMR, de raitis, ALBI, and ABR are calculated. CTP and MELD scores were calculated by taking data from the patient's medical recordResultOf the 96 patients tested in our study, the majority were male (66). The study found a significant moderate to very strong relationship to the MELD score between ACR, APRI, ALBI, ABR, LMR, WBC, sodium, and albumin. Neutrophil to lymphocyte ratio, ACR, De ritis, APRI, LMR, ALBI, ABR, sodium levels, and albumin have a moderate to very strong significant relationship to CTP score. ACR, De ritis, APRI, LMR, ALBI, ABR, WBC, sodium, and albumin levels with respective cut-offs £ 3.6; ≥ 1.5; ≥ 0.3; £ 2.8; ≥ 0.7; £1.6; ≥ 6.7, £ 136.50, and £ 3.0 can be used to help predict decompensated cirrhosisConclusionIn addition to using the CTP score and MELD score as a tool to predict the severity of liver cirrhosis, data from laboratory examination results in the form of albumin and ABR levels can help establish the diagnosis of decompensated cirrhosis. The sensitivity and specificity of ABR were 96.8% and 75.4% with a cut-off of £ 1.6, while albumin levels were 93.5% and 81.5% with an amount off of £ 3.0.
{"title":"Correlation of Simple Laboratory Result Parameters to CTP and MELD Scores, and the Diagnostic Role of Simple Laboratory Indexes to Cirrhosis Decompansation","authors":"Ni Nyoman Gita Kharisma Dewi, Ni Luh Putu Yunia Dewi, Putu Itta Sandi Lesmana Dewi, K. M. N. Pamungkas, D. A. Sindhughosa, I. K. Mariadi","doi":"10.24871/251202427-33","DOIUrl":"https://doi.org/10.24871/251202427-33","url":null,"abstract":"BackgroundCirrhosis of the liver is a final condition of all chronic liver diseases. Liver cirrhosis is the leading cause of increasing morbidity and mortality in adults worldwide. Systemic inflammation has been suggested to play an important role in causing progressive liver damage and is one of the leading causes of compensated and decompensated liver cirrhosis.Aim of StudyEvaluate the correlation of neutrophil-lymphocyte ratio (NLR), albumin-bilirubin ratio (ABR), albumin-bilirubin score (ALBI), aspartate aminotransferase to platelet ratio (APRI), albumin-creatinine ratio (ACR), lymphocyte-monocyte ratio (LMR), de ritis ratio to the severity of liver cirrhosis as assessed by CTP score and MELD score. In addition, this study also evaluated the diagnostic ability of NLR, ABR, ALBI, APRI, ACR, LMR, de ritis ratio, and CTP and MELD scores in predicting decompensated liver cirrhosis.MethodWe conducted a cross-sectional study involving patients diagnosed with liver cirrhosis at Prof DR IGNG Ngoerah General Hospital. All patients were diagnosed based on clinical history, physical examination, and investigations. This study enrolled 96 cirrhotic patients regardless of etiology. Laboratory examination results recorded platelets, neutrophils, lymphocytes, monocytes, AST, ALT, albumin, and creatinine. Then NLR, ACR, APRI, LMR, de raitis, ALBI, and ABR are calculated. CTP and MELD scores were calculated by taking data from the patient's medical recordResultOf the 96 patients tested in our study, the majority were male (66). The study found a significant moderate to very strong relationship to the MELD score between ACR, APRI, ALBI, ABR, LMR, WBC, sodium, and albumin. Neutrophil to lymphocyte ratio, ACR, De ritis, APRI, LMR, ALBI, ABR, sodium levels, and albumin have a moderate to very strong significant relationship to CTP score. ACR, De ritis, APRI, LMR, ALBI, ABR, WBC, sodium, and albumin levels with respective cut-offs £ 3.6; ≥ 1.5; ≥ 0.3; £ 2.8; ≥ 0.7; £1.6; ≥ 6.7, £ 136.50, and £ 3.0 can be used to help predict decompensated cirrhosisConclusionIn addition to using the CTP score and MELD score as a tool to predict the severity of liver cirrhosis, data from laboratory examination results in the form of albumin and ABR levels can help establish the diagnosis of decompensated cirrhosis. The sensitivity and specificity of ABR were 96.8% and 75.4% with a cut-off of £ 1.6, while albumin levels were 93.5% and 81.5% with an amount off of £ 3.0.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"18 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cosmas Rinaldi Adithya Paramitha, M. S. Paramitha, Yulia Estu Pratiwi, L. Lesmana
Introduction: In the era of laparoscopic procedure, there are innovations on non-surgical management approaches for managing biliary tract disorders, such as therapeutic endoscopic retrograde cholangiopancreatography (ERCP) and interventional endoscopic ultrasound (EUS). There is still no clear consensus yet in step-approach for managing difficult biliary disorders. Method: A retrospective endoscopy database study was conducted. Complex biliary cases which included in this study, where multi-management approach is needed, biliary obstruction accompanied with cholangitis or biliary sepsis, difficult CBD stone, recurrent CBD stone, or advanced progressive malignant biliary obstruction. Results: Sixty-one subjects in this retrospective database study were considered as complex biliary cases. In this study, 16.4% of the subjects underwent combination of therapeutic ERCP and EUS in one session based on the complexity of the case; and 8.2% of the subjects underwent therapeutic ERCP with additional single operator cholangioscopy procedure. One subject underwent rendezvous ERCP procedure through percutaneous approach. Around 4.9% of the subjects underwent EUS-guided biliary drainage procedure. Conclusion: Complex biliary cases require a good clinical approach algorithm to decide which procedure comes first based on comprehensive evaluation consists of patient’s factor, expertise, cost, and the risk of complications. Keywords: biliary tract; endoscopic retrograde cholangiography; endoscopic ultrasound; laparoscopic procedure
导言：在腹腔镜手术时代，非手术治疗胆道疾病的方法不断创新，如治疗性内镜逆行胰胆管造影术（ERCP）和介入性内镜超声波检查（EUS）。对于如何分步治疗疑难胆道疾病，目前还没有明确的共识。方法：进行了一项回顾性内镜数据库研究。复杂胆道病例包括：胆道梗阻伴有胆管炎或胆道败血症、难治性CBD结石、复发性CBD结石或晚期进展性恶性胆道梗阻。研究结果在这项回顾性数据库研究中，61 名受试者被视为复杂胆道病例。在这项研究中，16.4%的受试者根据病例的复杂程度在一次治疗中接受了ERCP和EUS联合治疗；8.2%的受试者在接受ERCP治疗的同时接受了单人胆道镜检查。一名受试者通过经皮途径进行了会合ERCP手术。约 4.9% 的受试者接受了 EUS 引导下的胆道引流术。结论复杂的胆道病例需要一个良好的临床方法算法，根据患者的因素、专业知识、成本和并发症风险等综合评估来决定先进行哪种手术。关键词：胆道；内镜逆行性胆管造影；内镜超声；腹腔镜手术
{"title":"Clinical Approach Strategy in Managing Complex Biliary Cases: Lesson learnt from a tertiary referral private hospital","authors":"Cosmas Rinaldi Adithya Paramitha, M. S. Paramitha, Yulia Estu Pratiwi, L. Lesmana","doi":"10.24871/25120242-10","DOIUrl":"https://doi.org/10.24871/25120242-10","url":null,"abstract":"Introduction: In the era of laparoscopic procedure, there are innovations on non-surgical management approaches for managing biliary tract disorders, such as therapeutic endoscopic retrograde cholangiopancreatography (ERCP) and interventional endoscopic ultrasound (EUS). There is still no clear consensus yet in step-approach for managing difficult biliary disorders. Method: A retrospective endoscopy database study was conducted. Complex biliary cases which included in this study, where multi-management approach is needed, biliary obstruction accompanied with cholangitis or biliary sepsis, difficult CBD stone, recurrent CBD stone, or advanced progressive malignant biliary obstruction. Results: Sixty-one subjects in this retrospective database study were considered as complex biliary cases. In this study, 16.4% of the subjects underwent combination of therapeutic ERCP and EUS in one session based on the complexity of the case; and 8.2% of the subjects underwent therapeutic ERCP with additional single operator cholangioscopy procedure. One subject underwent rendezvous ERCP procedure through percutaneous approach. Around 4.9% of the subjects underwent EUS-guided biliary drainage procedure. Conclusion: Complex biliary cases require a good clinical approach algorithm to decide which procedure comes first based on comprehensive evaluation consists of patient’s factor, expertise, cost, and the risk of complications. Keywords: biliary tract; endoscopic retrograde cholangiography; endoscopic ultrasound; laparoscopic procedure","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：