Cokorde Istri Yuliandari Krisnawardani Kumbara, I. K. Mariadi, G. Somayana, I. Wibawa, D. A. Sindhughosa
Background: Coronavirus Disease 2019 (COVID-19) can affect not only the respiratory system but also other organs such as the liver. Liver injury tends to occur in severe disease of COVID-19 patients and might contribute to clinical outcomes for patients. This study aimed to find the relationship between the severity of liver injury with clinical outcome and duration of hospitalizations.Methods: This study was a retrospective study of hospitalized COVID-19 patients period April 2020 to April 2021. The inclusion criteria were severe COVID-19 patients who developed a liver injury. The severity of the liver injury was classified into mild, moderate, and severe. The relationship between the severity of liver injury with clinical outcome and duration of hospitalization was analyzed. Univariate and logistic regression were used. Results: 90 samples fill the inclusion criteria. The liver injury severity was statistically significantly related to clinical outcome patients (p= 0.047), which is the increase in liver injury severity resulting in poor clinical outcomes. No significant relationship was found between the severity of liver injury with the duration of hospitalization.Conclusion: liver injury increases mortality in severe COVID-19 patients.
{"title":"Severity of Liver Injury and Its Relation to Clinical Outcome and Duration of Hospitalization in COVID 19 Patients","authors":"Cokorde Istri Yuliandari Krisnawardani Kumbara, I. K. Mariadi, G. Somayana, I. Wibawa, D. A. Sindhughosa","doi":"10.24871/251202447-52","DOIUrl":"https://doi.org/10.24871/251202447-52","url":null,"abstract":"Background: Coronavirus Disease 2019 (COVID-19) can affect not only the respiratory system but also other organs such as the liver. Liver injury tends to occur in severe disease of COVID-19 patients and might contribute to clinical outcomes for patients. This study aimed to find the relationship between the severity of liver injury with clinical outcome and duration of hospitalizations.Methods: This study was a retrospective study of hospitalized COVID-19 patients period April 2020 to April 2021. The inclusion criteria were severe COVID-19 patients who developed a liver injury. The severity of the liver injury was classified into mild, moderate, and severe. The relationship between the severity of liver injury with clinical outcome and duration of hospitalization was analyzed. Univariate and logistic regression were used. Results: 90 samples fill the inclusion criteria. The liver injury severity was statistically significantly related to clinical outcome patients (p= 0.047), which is the increase in liver injury severity resulting in poor clinical outcomes. No significant relationship was found between the severity of liver injury with the duration of hospitalization.Conclusion: liver injury increases mortality in severe COVID-19 patients.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"119 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Loho, Lianda Siregar, Dewi Iriani, Tiyas Hasnaa Faatinah
Patients with metastatic cervical cancer, particularly hematogenous metastasis, have a worse prognosis compared to those with localized cervical cancer. Gastrointestinal involvement of cervical cancer occurs in approximately 8% of cases and most lesions are located in the recto-sigmoid area due to direct extension of the disease. Here, we present a case of cervical adenocarcinoma spreading to the ascending colon as a sessile polyp and mimicking a hyperplastic polyp. Histopathological evaluation followed by immunohistochemistry analysis is needed to confirm the diagnosis.
{"title":"Metastatic Cervical Cancer Presenting as a Sessile Polyp in the Ascending Colon","authors":"I. Loho, Lianda Siregar, Dewi Iriani, Tiyas Hasnaa Faatinah","doi":"10.24871/251202494-97","DOIUrl":"https://doi.org/10.24871/251202494-97","url":null,"abstract":"Patients with metastatic cervical cancer, particularly hematogenous metastasis, have a worse prognosis compared to those with localized cervical cancer. Gastrointestinal involvement of cervical cancer occurs in approximately 8% of cases and most lesions are located in the recto-sigmoid area due to direct extension of the disease. Here, we present a case of cervical adenocarcinoma spreading to the ascending colon as a sessile polyp and mimicking a hyperplastic polyp. Histopathological evaluation followed by immunohistochemistry analysis is needed to confirm the diagnosis.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"25 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of other causes of liver fat accumulation. The prevalence of NAFLD is increasing and now among top causes of hepatocellular carcinoma. The diagnosis of NAFLD requires evidence from liver biopsy. There are currently no specific drugs for therapy of NAFLD. Current mainstay for management of NAFLD is lifestyle interventions focused around weight loss. Lifestyle interventions can be done by dietary modification or increasing physical activity level. Pioglitazone and vitamin E are only recommended for patient whom was confirmed NAFLD by liver biopsy. New agents such as obeticholic acid, elafibranor, selonsertib, and cenicriviroc are still waiting for phase III result to be recommended as therapy for NAFLD. Bariatric surgery can be advised for NAFLD patient with obesity who is not adequately controlled by medical therapy.
非酒精性脂肪肝（NAFLD）的特点是在没有其他肝脏脂肪堆积原因的情况下出现肝脂肪变性。非酒精性脂肪肝的发病率正在上升，目前已成为肝细胞癌的主要病因之一。非酒精性脂肪肝的诊断需要肝活检的证据。目前还没有治疗非酒精性脂肪肝的特效药物。目前治疗非酒精性脂肪肝的主要方法是以减肥为中心的生活方式干预。生活方式干预可通过调整饮食或增加体育锻炼来实现。吡格列酮和维生素 E 只推荐给通过肝活检证实患有非酒精性脂肪肝的患者。新的药物，如 obeticholic acid、elafibranor、selonsertib 和 cenicriviroc 等，仍在等待 III 期研究结果，以推荐作为治疗非酒精性脂肪肝的药物。如果非酒精性脂肪肝患者因肥胖而无法通过药物治疗得到充分控制，可建议其接受减肥手术。
{"title":"Current Management of Non-Alcoholic Fatty Liver Disease (NAFLD)","authors":"Benny Budiman","doi":"10.24871/251202463-70","DOIUrl":"https://doi.org/10.24871/251202463-70","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of other causes of liver fat accumulation. The prevalence of NAFLD is increasing and now among top causes of hepatocellular carcinoma. The diagnosis of NAFLD requires evidence from liver biopsy. There are currently no specific drugs for therapy of NAFLD. Current mainstay for management of NAFLD is lifestyle interventions focused around weight loss. Lifestyle interventions can be done by dietary modification or increasing physical activity level. Pioglitazone and vitamin E are only recommended for patient whom was confirmed NAFLD by liver biopsy. New agents such as obeticholic acid, elafibranor, selonsertib, and cenicriviroc are still waiting for phase III result to be recommended as therapy for NAFLD. Bariatric surgery can be advised for NAFLD patient with obesity who is not adequately controlled by medical therapy.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"11 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Non-variceal upper gastrointestinal bleeding (UGIB) is a common case of emergency in daily clinical practice with a fairly high mortality rate. The use of tranexamic acid, which has been recommended in managing trauma bleeding, may serve as an alternative pharmacological therapy to manage bleeding in non-variceal UGIB. This evidence-based case report aims to evaluate the impact of tranexamic acid on managing bleeding, risk of mortality, and thromboembolic event in non-variceal UGIB patients.Methods: A systematic literature search was conducted on 4 databases: CDSR, EMBASE, PubMed, and Scopus for meta-analyses. Studies were selected based on inclusion and exclusion criteria formulated a-priori with subsequent critical appraisal according to the OCEBM critical appraisal tools. Result: Meta analyses by Kamal, et al (2020) and Twum-Barimah, et al (2020) were included in our report. Kamal, et al shows no significant difference in mortality in tranexamic acid use compared to placebo (RR 0.84; 95%CI 0.63–1.11; I2=2%). Similarly, although Twum-Barimah reported tranexamic acid reduced risk of mortality compared to placebo (RR 0.45; 95%CI 0.23–0.88; p=0.02; I2 = 0%), none of the RCTs included shows significant result when observed individually. In addition, Kamal, et al also reported increased risk of vein thromboembolic events in high-dose tranexamic acid administration (RR 2.21; 95%CI 1.32–3.69; I2=0%) compared to low-dose administration, in UGIB patients.Conclusion: Tranexamic acid is not recommended to be used in managing bleeding in patients non-variceal UGIB patients and may increase the risk of thromboembolic event.
{"title":"Tranexamic Acid in the Management of Non-variceal Upper Gastrointestinal Bleeding","authors":"Muhammad Reza, S. A. Nursyirwan","doi":"10.24871/251202483-93","DOIUrl":"https://doi.org/10.24871/251202483-93","url":null,"abstract":"Background: Non-variceal upper gastrointestinal bleeding (UGIB) is a common case of emergency in daily clinical practice with a fairly high mortality rate. The use of tranexamic acid, which has been recommended in managing trauma bleeding, may serve as an alternative pharmacological therapy to manage bleeding in non-variceal UGIB. This evidence-based case report aims to evaluate the impact of tranexamic acid on managing bleeding, risk of mortality, and thromboembolic event in non-variceal UGIB patients.Methods: A systematic literature search was conducted on 4 databases: CDSR, EMBASE, PubMed, and Scopus for meta-analyses. Studies were selected based on inclusion and exclusion criteria formulated a-priori with subsequent critical appraisal according to the OCEBM critical appraisal tools. Result: Meta analyses by Kamal, et al (2020) and Twum-Barimah, et al (2020) were included in our report. Kamal, et al shows no significant difference in mortality in tranexamic acid use compared to placebo (RR 0.84; 95%CI 0.63–1.11; I2=2%). Similarly, although Twum-Barimah reported tranexamic acid reduced risk of mortality compared to placebo (RR 0.45; 95%CI 0.23–0.88; p=0.02; I2 = 0%), none of the RCTs included shows significant result when observed individually. In addition, Kamal, et al also reported increased risk of vein thromboembolic events in high-dose tranexamic acid administration (RR 2.21; 95%CI 1.32–3.69; I2=0%) compared to low-dose administration, in UGIB patients.Conclusion: Tranexamic acid is not recommended to be used in managing bleeding in patients non-variceal UGIB patients and may increase the risk of thromboembolic event.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"30 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The knowledge of CRC and its screening methods of healthcare workers is the bedrock of CRC early detection particularly in countries lacking national screening programs. Unknown factors influencing colorectal cancer early detection program implementation. We aimed to evaluate the knowledge and attitudes of primary health care (PHC) provider regarding CRC screening and identify the barriers associated with the screening plan.Methods: A cross-sectional study was conducted among PHC physicians and nurses in public primary health care centers in Bali, Indonesia. A 44-item self-administered questionnaire was used to assess the knowledge, attitude and practice of CRC screening. The questionnaire was spread using google form. Results: Two hundred and five respondents have participated in this study. The average duration of doing practice in PHC is 6.6 years. In knowledge of CRC, 50.2% of them have good knowledge, and there is no difference between PCPs vs nurses (51.9% vs 47.3%; p=0.53). In attitude toward CRC screening, 58.5% out of the have good attitude, and there is no difference between PCPs vs nurses (60.3% vs 55.4%; p=0.50). The barriers of the screening was divided into two areas, a barrier from the health care system and patients. There was no association between knowledge and attitude towards CRC screening (p=0.63).Conclusion: The majority of health workers' knowledge and attitudes toward CRC screening were in the "good" category. The patient's fear of being diagnosed with cancer, as well as the patient's fear and anxiety of screening tests, is the most significant barrier to colorectal cancer screening.
{"title":"Knowledge, Attitude and Obstacles of Colorectal Cancer Screening in Primary Health Care in Bali, Indonesia","authors":"I. K. Mariadi, G. Somayana, D. A. Sindhughosa","doi":"10.24871/2432023235","DOIUrl":"https://doi.org/10.24871/2432023235","url":null,"abstract":"Background: The knowledge of CRC and its screening methods of healthcare workers is the bedrock of CRC early detection particularly in countries lacking national screening programs. Unknown factors influencing colorectal cancer early detection program implementation. We aimed to evaluate the knowledge and attitudes of primary health care (PHC) provider regarding CRC screening and identify the barriers associated with the screening plan.Methods: A cross-sectional study was conducted among PHC physicians and nurses in public primary health care centers in Bali, Indonesia. A 44-item self-administered questionnaire was used to assess the knowledge, attitude and practice of CRC screening. The questionnaire was spread using google form. Results: Two hundred and five respondents have participated in this study. The average duration of doing practice in PHC is 6.6 years. In knowledge of CRC, 50.2% of them have good knowledge, and there is no difference between PCPs vs nurses (51.9% vs 47.3%; p=0.53). In attitude toward CRC screening, 58.5% out of the have good attitude, and there is no difference between PCPs vs nurses (60.3% vs 55.4%; p=0.50). The barriers of the screening was divided into two areas, a barrier from the health care system and patients. There was no association between knowledge and attitude towards CRC screening (p=0.63).Conclusion: The majority of health workers' knowledge and attitudes toward CRC screening were in the \"good\" category. The patient's fear of being diagnosed with cancer, as well as the patient's fear and anxiety of screening tests, is the most significant barrier to colorectal cancer screening.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, and its correct diagnosis is an area of interest for clinicians. A 44-year-old man, presented with bloating for 1 month and getting worsened 1 day before admission to emergency room (ER), accompanied by discomfort in the upper left abdomen. The patient had abdominal distension, no vomiting or severe abdominal pain. Ultrasonography (USG) transabdominal revealed polyp gallbladder, no stone or pancreatitis. Magnetic resonance imaging (MRI) 2 months before at the ER, showed multiple stone in gallbladder and normal pancreas. Leukocytes 15 x 103/L, serum glutamic pyruvic transaminase (SGPT) 262, serum glutamic oxaloacetic transaminase (SGOT) 249, gamma glutamyl transferase (GGT) 1369 U/L, total bilirubin (TBIL) 2.44, direct bilirubin (DBIL) 2.08, lipase 14,690 U/L, amylase 3,693 U/L. Patient refused computerized tomography scan (CT scan) or MRI repeated, based on Atlanta criteria, abdominal discomfort with high amylase/lipase and a history of gallstones, the diagnosis was made. After 3 days, SGPT 44, SGOT 19, GGT 732 U/L, lipase 46 U/L, amylase 38 U/L. Based on Atlanta classification, AP diagnosed if at least 2 of the following 3 criteria are fulfilled: abdominal pain, serum lipase or amylase at least 3x the upper limit of normal (ULN) or characteristic findings on imaging. Gallstones are the most cause of AP. Abdominal bloating in this patient couldn’t be explained by common causes, such as ascites, bowel edema, hematoma, ileus which led us to suspect pancreatitis. CT scan contrast or MRI was essential in patients with normal USG and no classic sign abdominal pain.
{"title":"Acute Pancreatitis with Abdominal Bloating and Normal Transabdominal Ultrasound","authors":"Silvikarina Erfanti Dewi Halim","doi":"10.24871/2432023-270","DOIUrl":"https://doi.org/10.24871/2432023-270","url":null,"abstract":"Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, and its correct diagnosis is an area of interest for clinicians. A 44-year-old man, presented with bloating for 1 month and getting worsened 1 day before admission to emergency room (ER), accompanied by discomfort in the upper left abdomen. The patient had abdominal distension, no vomiting or severe abdominal pain. Ultrasonography (USG) transabdominal revealed polyp gallbladder, no stone or pancreatitis. Magnetic resonance imaging (MRI) 2 months before at the ER, showed multiple stone in gallbladder and normal pancreas. Leukocytes 15 x 103/L, serum glutamic pyruvic transaminase (SGPT) 262, serum glutamic oxaloacetic transaminase (SGOT) 249, gamma glutamyl transferase (GGT) 1369 U/L, total bilirubin (TBIL) 2.44, direct bilirubin (DBIL) 2.08, lipase 14,690 U/L, amylase 3,693 U/L. Patient refused computerized tomography scan (CT scan) or MRI repeated, based on Atlanta criteria, abdominal discomfort with high amylase/lipase and a history of gallstones, the diagnosis was made. After 3 days, SGPT 44, SGOT 19, GGT 732 U/L, lipase 46 U/L, amylase 38 U/L. Based on Atlanta classification, AP diagnosed if at least 2 of the following 3 criteria are fulfilled: abdominal pain, serum lipase or amylase at least 3x the upper limit of normal (ULN) or characteristic findings on imaging. Gallstones are the most cause of AP. Abdominal bloating in this patient couldn’t be explained by common causes, such as ascites, bowel edema, hematoma, ileus which led us to suspect pancreatitis. CT scan contrast or MRI was essential in patients with normal USG and no classic sign abdominal pain.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The presence of gallstones in the common biliary duct is known as choledocholithiasis. Obstructive jaundice is the main clinical manifestation, which can cause acute cholangitis characterized by fever, jaundice, and right upper quadrant abdominal pain. The best diagnostic modality for choledocholithiasis is magnetic resonance cholangiopancreatography (MRCP). The treatment of choledocholithiasis involves extraction of gallstones using endoscopic retrograde cholangiopancreatography (ERCP), followed by stenting, and then cholecystectomy.
{"title":"Current Diagnosis and Treatment of Choledocholithiasis","authors":"Kaka Renaldi, Fauzan Hertrisno Firman","doi":"10.24871/2432023256","DOIUrl":"https://doi.org/10.24871/2432023256","url":null,"abstract":"The presence of gallstones in the common biliary duct is known as choledocholithiasis. Obstructive jaundice is the main clinical manifestation, which can cause acute cholangitis characterized by fever, jaundice, and right upper quadrant abdominal pain. The best diagnostic modality for choledocholithiasis is magnetic resonance cholangiopancreatography (MRCP). The treatment of choledocholithiasis involves extraction of gallstones using endoscopic retrograde cholangiopancreatography (ERCP), followed by stenting, and then cholecystectomy.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"225 4-5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clostridium difficile infection (CDI) was first viewed as a nosocomial infection as it is associated with antibiotics administration. But since antibiotics are more frequently to be prescribed in the community setting, clinicians should investigate the probability of all antibiotics-associated diarrhea as CDI.Diagnostic of CDI should be conducted cautiously as the manifestation of CDI varies from asymptomatic to fatal consequences and is associated with morbidity, mortality, recurrence risk, outbreak possibility, and low quality of life. Management of this infection should include infection prevention and control, stopping the offending antibiotics, and administration of specific antimicrobials.Clinicians should also recognize the risk of recurrence and the higher probability of less efficacious specific antimicrobials in each episode of recurrence.
{"title":"Diagnostic Approach and Management of Clostridium difficile Infection","authors":"F. N. Hosea, Achmad Fauzi","doi":"10.24871/2432023250","DOIUrl":"https://doi.org/10.24871/2432023250","url":null,"abstract":"Clostridium difficile infection (CDI) was first viewed as a nosocomial infection as it is associated with antibiotics administration. But since antibiotics are more frequently to be prescribed in the community setting, clinicians should investigate the probability of all antibiotics-associated diarrhea as CDI.Diagnostic of CDI should be conducted cautiously as the manifestation of CDI varies from asymptomatic to fatal consequences and is associated with morbidity, mortality, recurrence risk, outbreak possibility, and low quality of life. Management of this infection should include infection prevention and control, stopping the offending antibiotics, and administration of specific antimicrobials.Clinicians should also recognize the risk of recurrence and the higher probability of less efficacious specific antimicrobials in each episode of recurrence.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"47 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Helicobacter pylori infection is a gastrointestinal infection that affects about 50% of the world's population, however, its prevalence varies across geographic areas. The actual relationship of H. pylori with gastroesophageal reflux disease (GERD) is still unclear because some studies report a high prevalence of H. pylori in GERD patients, but some studies report the opposite. This study aims to determine the relationship between H. pylori infection and GERD and the prevalence of Helicobacter pylori infection in GERD patients at Eka Hospital Pekanbaru.Method: This study was a cross-sectional study of GERD patients who had undergone endoscopy at Eka Hospital Pekanbaru from January 2021 to December 2022. There were 219 patients. This research was then analyzed with the chi-square test using SPSS version 22.Results: A total of 219 GERD patients met the criteria for this study. 108 of them were positive for H. pylori from the results of endoscopic biopsies. The prevalence of GERD patients infected with H. pylori is 49.3%. 108 of them were positive patients, 14 (13%) GERD patients were ≥ 60 years old and 94 (87%) were 60 years old. Of the 108 positive patients, 53 (49.1%) were male, 55 (50.9%) were female. Where age and gender did not significantly increase the risk of H. pylori infection (p 0.05). The most common endoscopic biopsy finding is chronic erosive gastritis.Conclusion: Although the prevalence of GERD patients infected with H. pylori was quite large (49.3%), there was no significant association between GERD patients and the incidence of H. pylori infection.
{"title":"Relationship between Helicobacter pylori Infection and Gastroesophageal Reflux Disease (GERD)","authors":"Silvikarina Erfanti Dewi Halim","doi":"10.24871/2432023201","DOIUrl":"https://doi.org/10.24871/2432023201","url":null,"abstract":"Background: Helicobacter pylori infection is a gastrointestinal infection that affects about 50% of the world's population, however, its prevalence varies across geographic areas. The actual relationship of H. pylori with gastroesophageal reflux disease (GERD) is still unclear because some studies report a high prevalence of H. pylori in GERD patients, but some studies report the opposite. This study aims to determine the relationship between H. pylori infection and GERD and the prevalence of Helicobacter pylori infection in GERD patients at Eka Hospital Pekanbaru.Method: This study was a cross-sectional study of GERD patients who had undergone endoscopy at Eka Hospital Pekanbaru from January 2021 to December 2022. There were 219 patients. This research was then analyzed with the chi-square test using SPSS version 22.Results: A total of 219 GERD patients met the criteria for this study. 108 of them were positive for H. pylori from the results of endoscopic biopsies. The prevalence of GERD patients infected with H. pylori is 49.3%. 108 of them were positive patients, 14 (13%) GERD patients were ≥ 60 years old and 94 (87%) were 60 years old. Of the 108 positive patients, 53 (49.1%) were male, 55 (50.9%) were female. Where age and gender did not significantly increase the risk of H. pylori infection (p 0.05). The most common endoscopic biopsy finding is chronic erosive gastritis.Conclusion: Although the prevalence of GERD patients infected with H. pylori was quite large (49.3%), there was no significant association between GERD patients and the incidence of H. pylori infection.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Portal hypertension (PH) is still a big challenge in clinical practice, where the presence of esophageal varices (EV) is the most common complication found in liver cirrhosis (LC) patients. The progression of PH condition in LC patients would lead to decompensated stage with more complications, such as variceal bleeding, the presence of ascites, hepatic encephalopathy, and hepatorenal syndrome.[1,2] Bleeding of EV (BEV) is a critical clinical which carry high mortality. Therefore, not only early detection and how the PH condition can be diagnosed well, but also how we can manage to prevent its complication, especially for primary as well as secondary BEV prophylaxis.[3]
{"title":"ESOPHAGEAL VARICES REBLEEDING PROPHYLAXIS TREATMENT: WHO IS THE CHAMPION?","authors":"C. R. A. Lesmana","doi":"10.24871/2432023193","DOIUrl":"https://doi.org/10.24871/2432023193","url":null,"abstract":"Portal hypertension (PH) is still a big challenge in clinical practice, where the presence of esophageal varices (EV) is the most common complication found in liver cirrhosis (LC) patients. The progression of PH condition in LC patients would lead to decompensated stage with more complications, such as variceal bleeding, the presence of ascites, hepatic encephalopathy, and hepatorenal syndrome.[1,2] Bleeding of EV (BEV) is a critical clinical which carry high mortality. Therefore, not only early detection and how the PH condition can be diagnosed well, but also how we can manage to prevent its complication, especially for primary as well as secondary BEV prophylaxis.[3]","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"44 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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