Kevin Tandarto, Kadek Ari Suyandi, Lily Chandrawati
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the most widespread global pandemic since the 1918 influenza pandemic. The consequences of the coronavirus disease 2019 (COVID-19) are devastating and become the current world major public health issue. Not only SARS-CoV-2 attack the respiratory system, but also can affect multiple organs. Clinical manifestation varies from asymptomatic to severe multiorgan dysfunctions. COVID-19 is typically associated with a set of comorbidities such as hypertension, diabetes, obesity, and/or advanced age, which significantly exacerbates the consequences of infection. During the early stages of the disease, SARS-CoV-2 can also cause gastrointestinal symptoms such as vomiting, diarrhea, or abdominal pain. Intestinal dysfunction alters intestinal microbes and increases inflammatory cytokines. As a result, diagnosing gastrointestinal symptoms that procede respiratory problems during COVID-19 infection may be required for better early diagnosis and treatment. Discovering the composition of the microbiota and its metabolic products in the context of COVID-19 can aid in the identification of novel disease biomarkers and therapeutic targets. In the context of COVID-19, elucidating changes to the microbiome as reliable biomarkers represents an overlooked piece of the disease puzzle that requires further investigation.
{"title":"The Role of Gut Microbiota Dysbiosis as a Potential Factor in Early Diagnosis, Prognosis and Therapeutic Strategy of COVID-19 Patients","authors":"Kevin Tandarto, Kadek Ari Suyandi, Lily Chandrawati","doi":"10.24871/2432023-242","DOIUrl":"https://doi.org/10.24871/2432023-242","url":null,"abstract":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the most widespread global pandemic since the 1918 influenza pandemic. The consequences of the coronavirus disease 2019 (COVID-19) are devastating and become the current world major public health issue. Not only SARS-CoV-2 attack the respiratory system, but also can affect multiple organs. Clinical manifestation varies from asymptomatic to severe multiorgan dysfunctions. COVID-19 is typically associated with a set of comorbidities such as hypertension, diabetes, obesity, and/or advanced age, which significantly exacerbates the consequences of infection. During the early stages of the disease, SARS-CoV-2 can also cause gastrointestinal symptoms such as vomiting, diarrhea, or abdominal pain. Intestinal dysfunction alters intestinal microbes and increases inflammatory cytokines. As a result, diagnosing gastrointestinal symptoms that procede respiratory problems during COVID-19 infection may be required for better early diagnosis and treatment. Discovering the composition of the microbiota and its metabolic products in the context of COVID-19 can aid in the identification of novel disease biomarkers and therapeutic targets. In the context of COVID-19, elucidating changes to the microbiome as reliable biomarkers represents an overlooked piece of the disease puzzle that requires further investigation.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"149 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. B. Bestari, E. Rohmawaty, A. Rosdianto, H. Usman, W. A. M. Saragih, Ade Zuhrotun, Rini Hendriani, Yoga Windhu Wardhana, S. Ekawardhani, H. Wiraswati, N. Agustanti, Sumartini Dewi, Muhammad Palar Wijaya
Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.
背景：目前还没有一种具有抗肝纤维化作用的药物被批准用于治疗非酒精性脂肪肝（NAFLD）。Physalis angulata Linn.，印尼人更熟悉的名字是 ciplukan，具有治疗各种代谢性和炎症性疾病的天然能力。本研究旨在通过检测丙氨酸氨基转移酶（ALT）、胆固醇水平和肝脏组织病理学特征，确定P. angulata的乙酸乙酯馏分对非酒精性脂肪肝大鼠模型的影响：本研究是一项针对雄性 Wistar 大鼠的体内研究，于 2020 年 9 月至 11 月在 Padjadjaran 大学医学系动物实验室进行。大鼠被随机分为七组，每组五只。非酒精性脂肪肝模型是通过给大鼠喂食含20%人造黄油的食物制作而成，为期四周。干预组给予维生素 E、P. angulata 的乙酸乙酯馏分以及这两种物质的组合。统计分析根据组织病理学特征、谷丙转氨酶和胆固醇水平检查了各组的差异：结果：组织病理学结果显示，服用 0.32 毫克剂量 P. angulata 的组与正常肝脏相似，ALT 水平与维生素 E 相似：结论：0.32 毫克剂量的 P. angulata 乙酸乙酯馏分可改善非酒精性脂肪肝大鼠模型的组织病理学和血清 ALT 水平，这可能是 P. angulata 在非酒精性脂肪肝条件下抗纤维化能力的机制基础。
{"title":"Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats.","authors":"M. B. Bestari, E. Rohmawaty, A. Rosdianto, H. Usman, W. A. M. Saragih, Ade Zuhrotun, Rini Hendriani, Yoga Windhu Wardhana, S. Ekawardhani, H. Wiraswati, N. Agustanti, Sumartini Dewi, Muhammad Palar Wijaya","doi":"10.24871/2432023206","DOIUrl":"https://doi.org/10.24871/2432023206","url":null,"abstract":"Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"73 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mentari Adinda Setiawan, U. U. Fasrini, Arni Amir, Masrul Muchtar, Saptino Miro, Endrinaldi Endrinaldi
Background: Gastroesophageal reflux disease (GERD), a common digestive problem, is increasing and affecting the individual’s quality of life. This study aimed to describe the characteristics of GERD patients at Dr. M. Djamil Central General Hospital.Method: This cross-sectional study used data from patients' medical records that involved 111 GERD patients, excluding chronic disease and pregnancy. The analysis used univariate analysis and performed the data in cross-tables.Results: The results indicated that demographically, nearly all of the samples fall within the range of productive age (94.59%), with a higher proportion of the female gender (54.05%), the majority having a middle education level (72.08%), being housewives (27.92%), and residing in Padang City (35.13%). Most of the main symptoms were heartburn (62.16%), followed by vomiting, nausea, and dysphagia (4.50%, 2.70%, and 1.80%). More patients received outpatient treatment with two visits (18.02%). Clinically, based on the BMI, the obese classification was higher (43.25%). The levels of triglycerides and total cholesterol in the blood of GERD patients were more in the normal category (60.60% and 61.80%), while the levels of HDL and LDL in the blood of GERD patients were in the abnormal category, with lower HDL (97.80%), and a higher LDL (72.70%).Conclusion: The majority of GERD patients were in the productive age group, female, middle level of education, housewives, and resided in Padang. Clinical characteristics of GERD patients included most were categorized as obese according to their BMI, main symptom heartburn, and treated as an outpatient. Triglyceride and total cholesterol were primarily normal; blood HDL and LDL were abnormal.
背景：胃食管反流病（GERD）是一种常见的消化系统疾病，其发病率不断上升，影响着人们的生活质量。本研究旨在描述 Dr. M. Djamil 中央综合医院胃食管反流病患者的特征：这项横断面研究使用了患者病历中的数据，涉及 111 名胃食管反流病患者，其中不包括慢性病患者和孕妇。分析采用单变量分析法，并对数据进行交叉表分析：结果表明，从人口统计学角度来看，几乎所有样本都属于生产年龄段（94.59%），女性比例较高（54.05%），大多数人具有中等教育水平（72.08%），是家庭主妇（27.92%），居住在巴东市（35.13%）。大多数主要症状是胃灼热（62.16%），其次是呕吐、恶心和吞咽困难（4.50%、2.70% 和 1.80%）。更多的患者接受了两次门诊治疗（18.02%）。在临床上，根据体重指数（BMI），肥胖的比例较高（43.25%）。胃食管反流患者血液中甘油三酯和总胆固醇的水平更多属于正常范畴（60.60% 和 61.80%），而胃食管反流患者血液中高密度脂蛋白和低密度脂蛋白的水平则属于异常范畴，其中高密度脂蛋白较低（97.80%），低密度脂蛋白较高（72.70%）：大多数胃食管反流病患者处于生产年龄段，女性，中等教育水平，家庭主妇，居住在巴东。胃食管反流病患者的临床特征包括：大多数根据体重指数被归类为肥胖，主要症状为烧心，在门诊接受治疗。甘油三酯和总胆固醇基本正常；血液中的高密度脂蛋白和低密度脂蛋白异常。
{"title":"Characteristics of Gastroesophageal Reflux Disease (GERD) Patients at RSUP Dr. M. Djamil Padang Period 2018-2021","authors":"Mentari Adinda Setiawan, U. U. Fasrini, Arni Amir, Masrul Muchtar, Saptino Miro, Endrinaldi Endrinaldi","doi":"10.24871/2432023227","DOIUrl":"https://doi.org/10.24871/2432023227","url":null,"abstract":"Background: Gastroesophageal reflux disease (GERD), a common digestive problem, is increasing and affecting the individual’s quality of life. This study aimed to describe the characteristics of GERD patients at Dr. M. Djamil Central General Hospital.Method: This cross-sectional study used data from patients' medical records that involved 111 GERD patients, excluding chronic disease and pregnancy. The analysis used univariate analysis and performed the data in cross-tables.Results: The results indicated that demographically, nearly all of the samples fall within the range of productive age (94.59%), with a higher proportion of the female gender (54.05%), the majority having a middle education level (72.08%), being housewives (27.92%), and residing in Padang City (35.13%). Most of the main symptoms were heartburn (62.16%), followed by vomiting, nausea, and dysphagia (4.50%, 2.70%, and 1.80%). More patients received outpatient treatment with two visits (18.02%). Clinically, based on the BMI, the obese classification was higher (43.25%). The levels of triglycerides and total cholesterol in the blood of GERD patients were more in the normal category (60.60% and 61.80%), while the levels of HDL and LDL in the blood of GERD patients were in the abnormal category, with lower HDL (97.80%), and a higher LDL (72.70%).Conclusion: The majority of GERD patients were in the productive age group, female, middle level of education, housewives, and resided in Padang. Clinical characteristics of GERD patients included most were categorized as obese according to their BMI, main symptom heartburn, and treated as an outpatient. Triglyceride and total cholesterol were primarily normal; blood HDL and LDL were abnormal.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"127 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding.Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Embase) and individual hand searching. The selected studies were then critically appraised for their validity, importance, and applicability.Results: A total of 136 results were retrieved, and 2 systematic reviews and meta-analysis of randomized controlled trials (RCTs) were selected. Both studies showed that TIPS significantly decreased incidence of esophageal variceal rebleeding but had no significant effect on reducing overall mortality when compared to combination therapy. Study by Lin et al found that TIPS was significantly better than combination therapy for reducing mortality from variceal rebleeding, but study by Jing et al found no significant difference.Conclusion: TIPS is superior to combination therapy in reducing the incidence of esophageal variceal rebleeding. Nevertheless, its effectiveness in reducing mortality needs further investigation. Future research should look into its complications and cost-effectiveness in developing countries like Indonesia.
{"title":"Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker","authors":"Edward Christopher Yo, S. A. Nursyirwan","doi":"10.24871/2432023275","DOIUrl":"https://doi.org/10.24871/2432023275","url":null,"abstract":"Aim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding.Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Embase) and individual hand searching. The selected studies were then critically appraised for their validity, importance, and applicability.Results: A total of 136 results were retrieved, and 2 systematic reviews and meta-analysis of randomized controlled trials (RCTs) were selected. Both studies showed that TIPS significantly decreased incidence of esophageal variceal rebleeding but had no significant effect on reducing overall mortality when compared to combination therapy. Study by Lin et al found that TIPS was significantly better than combination therapy for reducing mortality from variceal rebleeding, but study by Jing et al found no significant difference.Conclusion: TIPS is superior to combination therapy in reducing the incidence of esophageal variceal rebleeding. Nevertheless, its effectiveness in reducing mortality needs further investigation. Future research should look into its complications and cost-effectiveness in developing countries like Indonesia.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"18 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BSTRACT[WU1] [DM2] Background: Recent studies showed contrasting associations between Helicobacter pylori infection and organic bowel disorders, where positive associations were reported in colorectal carcinoma (CRC) and colorectal polyp, while a protective association was observed in patients with inflammatory bowel diseases (IBD). We aim to determine the association between H. pylori infection and CRC, colorectal polyps, and IBD in Indonesian tertiary Hospital.Method: We retrospectively collected data from patients referred to Dr. Cipto Mangunkusumo General National Hospital from 2010 to 2021 with a complete H. pylori test from electronic medical records. We performed a chi-square analysis and logistic regression with a significant p-value of 0.05.Results: Three hundred and fourteen patients were enrolled. Overall, the prevalence of H. pylori infection in organic bowel disease was 61.7% (n = 194), with 9.9% (n = 31) of them having CRC, 20.3% having colorectal polyps (n = 64), and 31.5% (n = 99) having IBD. A proven association between H. pylori infection and IBD was observed (RR = 0.36; 95% CI: 0.18‒0.70; p = 0.000). However, no significant association was found between H. pylori infection and CRC (RR = 0.60; 95% CI: 0.22–1.66; p = 0.31) and colon polyps (RR = 0.59; 95% CI: 0.30–1.15; p = 0.10).Conclusion: Our study suggested an association between H. pylori infection and IBD patients. However, an insignificant association was observed between H. pylori infection, CRC, and colorectal polyps. Keywords: Helicobacter pylori, inflammatory bowel disease, colorectal cancer, colorectal polyps
{"title":"Prevalence and Association of Helicobacter Pylori Infection in Bowel Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021","authors":"Dewi Mustikarani","doi":"10.24871/2432023222","DOIUrl":"https://doi.org/10.24871/2432023222","url":null,"abstract":"BSTRACT[WU1] [DM2] Background: Recent studies showed contrasting associations between Helicobacter pylori infection and organic bowel disorders, where positive associations were reported in colorectal carcinoma (CRC) and colorectal polyp, while a protective association was observed in patients with inflammatory bowel diseases (IBD). We aim to determine the association between H. pylori infection and CRC, colorectal polyps, and IBD in Indonesian tertiary Hospital.Method: We retrospectively collected data from patients referred to Dr. Cipto Mangunkusumo General National Hospital from 2010 to 2021 with a complete H. pylori test from electronic medical records. We performed a chi-square analysis and logistic regression with a significant p-value of 0.05.Results: Three hundred and fourteen patients were enrolled. Overall, the prevalence of H. pylori infection in organic bowel disease was 61.7% (n = 194), with 9.9% (n = 31) of them having CRC, 20.3% having colorectal polyps (n = 64), and 31.5% (n = 99) having IBD. A proven association between H. pylori infection and IBD was observed (RR = 0.36; 95% CI: 0.18‒0.70; p = 0.000). However, no significant association was found between H. pylori infection and CRC (RR = 0.60; 95% CI: 0.22–1.66; p = 0.31) and colon polyps (RR = 0.59; 95% CI: 0.30–1.15; p = 0.10).Conclusion: Our study suggested an association between H. pylori infection and IBD patients. However, an insignificant association was observed between H. pylori infection, CRC, and colorectal polyps. Keywords: Helicobacter pylori, inflammatory bowel disease, colorectal cancer, colorectal polyps ","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"44 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of 0.05.Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer
{"title":"Prevalence and Association of Helicobacter pylori Infection in Gastric Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021","authors":"Dewi Mustikarani","doi":"10.24871/2432023-216","DOIUrl":"https://doi.org/10.24871/2432023-216","url":null,"abstract":"Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of 0.05.Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"67 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Magfira, Arie Rozzaqi Nurrafiani, C. Jasirwan, R. Suhartono
Aim: This evidence-based case report aims to determine whether the surgical shunt is better than the trans-jugular intrahepatic portosystemic shunt (TIPS) to prevent re-bleeding in patients with portal hypertension due to liver cirrhosis. Method: Literature searching was performed in 4 online databases, Cochrane, PubMed, Embase, and SCOPUS. Three meta-analyses were appraised critically.Results: Of all meta-analyses included, the internal validities were poor and only included a small number of trials. However, the results show that surgical shunt is better for preventing variceal re-bleeding with varied heterogeneities.Conclusion: Surgical shunts may have benefits over TIPS in preventing variceal re-bleeding.
{"title":"Surgical Shunting Versus Trans-Jugular Intrahepatic Portosystemic Shunt for Recurrent Variceal Bleeding in Portal Hypertension Due to Liver Cirrhosis: An Evidence-Based Case Report","authors":"N. Magfira, Arie Rozzaqi Nurrafiani, C. Jasirwan, R. Suhartono","doi":"10.24871/2432023264","DOIUrl":"https://doi.org/10.24871/2432023264","url":null,"abstract":"Aim: This evidence-based case report aims to determine whether the surgical shunt is better than the trans-jugular intrahepatic portosystemic shunt (TIPS) to prevent re-bleeding in patients with portal hypertension due to liver cirrhosis. Method: Literature searching was performed in 4 online databases, Cochrane, PubMed, Embase, and SCOPUS. Three meta-analyses were appraised critically.Results: Of all meta-analyses included, the internal validities were poor and only included a small number of trials. However, the results show that surgical shunt is better for preventing variceal re-bleeding with varied heterogeneities.Conclusion: Surgical shunts may have benefits over TIPS in preventing variceal re-bleeding. ","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"101 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathasya Rizkyana Riyadi, Austin Bertilova Carmelita, Lia Sasmithae, Donna Novina Kahanjak, Ravenalla Abdurrahman Al Hakim Sampurna Putra S
Background: Cirrhosis is the final stage of liver disease characterized by fibrosis and irreversible nodule formation due to chronic inflammation. The most common liver cirrhosis complication is ascites, where pathological fluid accumulates in the peritoneal cavity. In cirrhosis, lymphocytes infiltrate the liver and contribute to stellate cell activation, differentiation, and the fibrogenic response. Many recent studies have not studied a relationship between the absolute lymphocyte count and ascites in liver cirrhosis. Therefore, it is important to investigate the relationship between lymphocytes and ascites in liver cirrhosis.Method: This is an observational study with a cross-sectional design study. Held in August–October 2022 at Dr. Doris Sylvanus Hospital's Medical Record Installation. 64 samples were selected based on inclusion and exclusion criteria. Meanwhile, absolute lymphocyte count were measured from the patient's blood tests or by calculation. Ascites were diagnosed by physical examination and radiology. The relationship between absolute lymphocyte count and ascites was analyzed using the chi-square test, with the results considered statistically significant when the p-value 0.05.Result: The medical records from April 2019 to April 2022, there were 64 samples, of which 15 and 49 were without and with ascites. Based on the chi-square test results, there was a significant relationship between absolute lymphocyte count and the incidence of ascites, with p = 0.02.Conclusion: This study concluded that there is a relationship between absolute lymphocyte count and ascites in patients with liver cirrhosis, where absolute lymphocyte count tends to decrease.
{"title":"Relationship between Absolute Lymphocyte Count and Ascites in Patients with Liver Cirrhosis","authors":"Nathasya Rizkyana Riyadi, Austin Bertilova Carmelita, Lia Sasmithae, Donna Novina Kahanjak, Ravenalla Abdurrahman Al Hakim Sampurna Putra S","doi":"10.24871/2432023195","DOIUrl":"https://doi.org/10.24871/2432023195","url":null,"abstract":"Background: Cirrhosis is the final stage of liver disease characterized by fibrosis and irreversible nodule formation due to chronic inflammation. The most common liver cirrhosis complication is ascites, where pathological fluid accumulates in the peritoneal cavity. In cirrhosis, lymphocytes infiltrate the liver and contribute to stellate cell activation, differentiation, and the fibrogenic response. Many recent studies have not studied a relationship between the absolute lymphocyte count and ascites in liver cirrhosis. Therefore, it is important to investigate the relationship between lymphocytes and ascites in liver cirrhosis.Method: This is an observational study with a cross-sectional design study. Held in August–October 2022 at Dr. Doris Sylvanus Hospital's Medical Record Installation. 64 samples were selected based on inclusion and exclusion criteria. Meanwhile, absolute lymphocyte count were measured from the patient's blood tests or by calculation. Ascites were diagnosed by physical examination and radiology. The relationship between absolute lymphocyte count and ascites was analyzed using the chi-square test, with the results considered statistically significant when the p-value 0.05.Result: The medical records from April 2019 to April 2022, there were 64 samples, of which 15 and 49 were without and with ascites. Based on the chi-square test results, there was a significant relationship between absolute lymphocyte count and the incidence of ascites, with p = 0.02.Conclusion: This study concluded that there is a relationship between absolute lymphocyte count and ascites in patients with liver cirrhosis, where absolute lymphocyte count tends to decrease.","PeriodicalId":515400,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy","volume":"46 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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