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Misconceptions Regarding Essential Oral Health Care Amongst Pregnant Women Visiting a Tertiary Care Hospital in the State of Goa, India: A Descriptive Study. 访问印度果阿州三级护理医院的孕妇对基本口腔保健的误解:一项描述性研究。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-06-29 DOI: 10.1007/s13224-023-01793-5
Shachi Prabhudessai, Ridhima Gaunkar, Amita Kenkre Kamat, Guruprasad Pednekar, Jagadish A Cacodcar

Background of the study: Myths regarding oral health are extensively prevalent and have considerable impact on pregnant women's dental behaviour and practices. Thus, this study sought to understand misconceptions (pregnancy and early childhood oral care) and their determinants amongst pregnant women.

Methods: A questionnaire designed to assess the participants' demographics, parity, oral health behaviour and misconceptions was administered to 305 pregnant women attending antenatal care. Oral health (DMFT, bleeding on probing and periodontal pocket) was examined. Independent t test, analysis of variance and linear regression were used for statistical computations.

Results: Early childhood myths (5.54 ± 1.87) were more prevalent amongst the study population than pregnancy-related myths (3.28 ± 1.89). Bivariate analysis exhibited that myths were significantly more prevalent in mothers who were ≤ 30 years of age (8.79 ± 2.565), primi parous (8.90 ± 2.141), illiterate (9.07 ± 2.764) and who had never visited a dentist (8.46 ± 2.016). Both pregnancy and early childhood myth scores were positively correlated to DMFT (p = 0.00; p = 0.031). Educational status and age were significant negative predictors of myths with p values of 0.00 and 0.34, respectively. Parity emerged as the only significant positive predictor (p = 0.002).

Conclusion: The high prevalence of myths in the present study advocates that standardized, culturally appropriate and simple educational messages need to be developed and delivered to break these misconceptions. Minimum one visit to a dental surgeon during second trimester should be advocated and encouraged for all pregnant women.

研究背景:关于口腔健康的神话非常普遍,对孕妇的牙科行为和实践有很大影响。因此,本研究试图了解孕妇的误解(怀孕和幼儿口腔护理)及其决定因素。方法:对305名参加产前护理的孕妇进行问卷调查,以评估参与者的人口统计学、产次、口腔健康行为和误解。检查口腔健康(DMFT、探查出血和牙周袋)。采用独立t检验、方差分析和线性回归进行统计计算。结果:幼儿神话(5.54 ± 1.87)在研究人群中比妊娠相关神话(3.28 ± 1.89)。双变量分析表明,神话在患有 ≤ 30岁(8.79 ± 2.565),初产(8.90 ± 2.141),文盲(9.07 ± 2.764)和从未看过牙医的人(8.46 ± 2.016)。妊娠和儿童早期神话评分均与DMFT呈正相关(p = 0.00;p = 0.031)。教育状况和年龄是神话的显著负预测因素,p值分别为0.00和0.34。奇偶性是唯一显著的阳性预测因子(p = 0.002)。结论:本研究中神话的高度流行表明,需要制定和传递标准化、文化适宜和简单的教育信息,以打破这些误解。应提倡并鼓励所有孕妇在妊娠中期至少去看一次牙科医生。
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引用次数: 0
Perception on Menstrual Cup Usage Among Teens and Reproductive Age Group Women: A Cross-Sectional Study. 青少年和育龄妇女对月经杯使用情况的认知:一项横断面研究。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-09-16 DOI: 10.1007/s13224-023-01825-0
Sangaraju Sreeja, Kavitha Garikapati, Vijayan Sharmila, M Yamini

Introduction: One of the challenges to menstrual hygiene management in resource-limited settings is limited access to safe and affordable menstrual hygiene products. An alternative to the widely used sanitary pads is the menstrual cup, which has received less attention in low- and middle-income countries. This study was carried out to assess the perception on menstrual cup usage among teens and reproductive age group women assess attending a tertiary care institute in a rural setup in Andhra Pradesh.

Methodology: A prospective cross-sectional study was conducted among 164 teenage and reproductive age group women attending the Outpatient Department of Obstetrics and Gynecology with the help of a semi-structured, pretested and pre-piloted questionnaire to assess the perception of menstrual cup usage among the participants. Data were analyzed statistically using software, menstrual cup knowledge score was calculated based on data obtained from questionnaire.

Results: Most of the study participants (87.8%) were using sanitary pads during menstruation. Cloth was also used by some of the participants (11.59%). Only one participant (0.61%) was reported using menstrual cup. Majority of the participants [121 (73.7%)] reported that they had never heard of menstrual cup, whereas 43 [(26.3%)] study participants reported that they were aware of menstrual cup. Only 2(4.65%) out of 43 participants had a good knowledge on menstrual cup whose knowledge score was 12. Five (11.63%) out of 43 participants had got 0 score and remaining participants got the score between 0 and 12.

Conclusion: Most of the women were not aware of menstrual cup and even if they know about it, they do not have good knowledge about it. Awareness regarding menstrual cup should be promoted through media and awareness programs to reach everyone.

引言:在资源有限的环境中,月经卫生管理面临的挑战之一是获得安全且负担得起的月经卫生产品的机会有限。广泛使用的卫生巾的一种替代品是月经杯,它在中低收入国家受到的关注较少。这项研究是为了评估青少年和育龄妇女对月经杯使用的看法,评估她们在安得拉邦农村地区的三级护理机构的情况。方法:在妇产科门诊部的164名青少年和育龄女性中进行了一项前瞻性的横断面研究半结构化、预测试和预试点问卷,以评估参与者对月经杯使用的感知。使用软件对数据进行统计分析,根据问卷数据计算月经杯知识得分。结果:大多数研究参与者(87.8%)在月经期间使用卫生巾。一些参与者(11.59%)也使用了布。据报道,只有一名参与者(0.61%)使用了月经杯。大多数参与者[121(73.7%)]报告他们从未听说过月经杯,而43(26.3%)]研究参与者报告他们知道月经杯。43名参与者中只有2人(4.65%)对月经杯有很好的了解,其知识得分为12。43名参与者中有5名(11.63%)的得分为0,其余参与者的得分在0到12之间。结论:大多数女性不知道月经杯,即使她们知道,也对它没有很好的了解。应该通过媒体和宣传计划来提高对月经杯的认识,让每个人都知道。
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引用次数: 0
Introducing Birth Companion in Labour: A Quality Improvement Initiative. 在分娩中引入生育伴侣:一项质量改进倡议。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-06-22 DOI: 10.1007/s13224-023-01780-w
Tamkin Khan, Ayesha Ahmad, Bushra Fatima, Saman Furqan, Enas Mushtaq, Tabassum Nawab, Aparna Sharma

Background: Birth companion (BC) has been globally recognised as an essential component of childbirth care. As our institution did not allow BC in labour, this study was planned as a quality improvement (QI) project to introduce the concept. We aimed to achieve birth companionship from existing 0 to 100% over a period of six months.

Intervention: QI team was constituted, and an initial brainstorming session conducted. A fishbone diagram was drawn to analyse issues that need addressal before implementation of the initiative. The framework was defined, and team members assigned their roles and responsibilities. A series of five successive Plan-Do-Study-Act (PDSA) cycles were carried out over a period of six months, which included introduction of the concept, dissemination of information, infrastructural changes in labour room and introducing column for documentation in birth register. To achieve sustainability, comprehensive group counselling sessions were started for women during antenatal period, and sensitisation classes were regularly conducted for newly inducted trainees and faculty.

Result: Birth companionship was achieved in 98% of cases.

Conclusion: The QI tools helped in preparation and planning of changes by breaking down a large problem into smaller sections and covering all aspects of challenges in a systematic manner using team-based approach. National directives and recommendations, sensitisation of leadership and training of stakeholders were found to be important facilitators. Robust systems of monitoring and successive PDSA cycles were needed for continuous improvement and sustainability of the idea.

背景:生育伴侣(BC)已被全球公认为分娩护理的重要组成部分。由于我们的机构不允许BC分娩,本研究计划作为一个质量改进(QI)项目来引入这一概念。我们的目标是在六个月内实现从0到100%的分娩陪伴。干预:QI团队成立,并进行了初步的头脑风暴会议。绘制了鱼骨图来分析在实施该倡议之前需要解决的问题。框架已经确定,团队成员分配了他们的角色和责任。在六个月的时间里,连续进行了五次计划研究法(PDSA)周期,其中包括引入概念、传播信息、改变产房的基础设施以及在出生登记册中引入文件栏。为了实现可持续性,在产前期间为妇女开办了全面的团体咨询课程,并定期为新入职的受训人员和教员举办宣传班。结果:98%的病例实现了出生陪伴。结论:QI工具通过将一个大问题分解为更小的部分,并使用基于团队的方法以系统的方式涵盖挑战的各个方面,有助于准备和规划变革。国家指令和建议、领导层的宣传和利益攸关方的培训被认为是重要的促进者。需要稳健的监测系统和连续的PDSA周期来持续改进和可持续发展这一理念。
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引用次数: 0
Role of Placental Vascularization Indices and Shear Wave Elastography in Fetal Growth Restriction. 胎盘血管舒张指数和剪切波弹性成像在胎儿生长受限中的作用。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-09-07 DOI: 10.1007/s13224-023-01826-z
Anagha Menon, Jyoti Meena, Smita Manchanda, Seema Singhal, Swati Shivhare, Sunesh Kumar

Objective: To evaluate the role of placental vascularisation indices using 3D-Power Doppler and placental elasticity using Shear Wave Elastography (SWE) in Fetal Growth Restricted (FGR) pregnancies and to assess their correlation with perinatal outcomes.

Methods: This prospective case-control study was conducted from June 2018-2020. Thirty women with FGR and thirty controls (24-36 weeks) underwent grayscale and Doppler ultrasonography followed by measurement of vascularisation indices and SWE from the central and peripheral parts of fetal and maternal surfaces of the placenta. Participants were followed till delivery and perinatal outcomes were noted.

Results: Vascularisation indices were significantly reduced among FGR vs. controls: Vascularisation Index (VI): 20.90 ± 5.46 vs. 31.49 ± 3.89, Flow Index (FI): 26.29 ± 1.70 vs. 30.85 ± 2.02, Vascularisation- Flow Index (VFI): 7.06 ± 2.42 vs. 12.37 ± 2.43, p < 0.001. The mean placental SWE (17.36 ± 1.50 kPa) in FGR pregnancies was significantly higher as compared to controls (4.14 ± 1.14 kPa), p < 0.001. Neonatal polycythaemia and hyperbilirubinemia were significantly increased in FGR pregnancies with higher SWE value. Receiver operating characteristic curve-based cut-off of VI for intensive care requirement was 23.0 (sensitivity: 75%, specificity: 71%) and for tachypnea was 22.8 (73% sensitivity and specificity). The cut-off of FI for low birth weight was 25.7 (sensitivity: 69.6%, specificity: 71.4%).

Conclusion: This study demonstrates that increased placental stiffness and reduced vascularisation in FGR indicate possible placental pathology. Both modalities help in predicting perinatal complications. Hence, vascularisation indices and SWE reflect the extent of placental insufficiency and can be useful adjuncts in diagnosis.

目的:评价三维功率多普勒胎盘血管形成指数和剪切波弹性成像胎盘弹性指数在胎儿生长受限(FGR)妊娠中的作用,并评估其与围产期结局的相关性。方法:本前瞻性病例对照研究于2018年6月至2020年6月进行。30名FGR妇女和30名对照组(24-36周)接受了灰度和多普勒超声检查,随后测量了胎儿和母体胎盘表面中央和外围部分的血管形成指数和SWE。对参与者进行随访,直到观察到分娩和围产期结果。结果:与对照组相比,FGR组的血管舒张指数显著降低:血管舒张指数(VI):20.90 ± 5.46对31.49 ± 3.89,流量指数(FI):26.29 ± 1.70对30.85 ± 2.02,血管舒张-流量指数(VFI):7.06 ± 2.42对12.37 ± 2.43,p p 结论:本研究表明,FGR中胎盘硬度增加和血管生成减少表明可能存在胎盘病理。这两种方式都有助于预测围产期并发症。因此,血管生成指数和SWE反映了胎盘功能不全的程度,可以作为诊断的有用辅助指标。
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引用次数: 0
Study of Post-hysterectomy Vault Prolapse and Surgical Management. 子宫切除术后拱顶脱垂及手术治疗的研究。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-05-15 DOI: 10.1007/s13224-023-01757-9
Hemangi J Kansaria, Tulika Chouhan

Purpose of study: To study the epidemiology and various methods of repair of vaginal vault prolapse in selected group of patients and the benefits of various modes of treatment in the management of vault prolapse.

Methods: Thirty-seven patients with grade lll or lV vault prolapse were enrolled in our study. Sacrospinous fixation was performed in 37 patients. High risk factors for prolapse, surgical results and complications were evaluated.

Results: In the current study, maximum cases of vault prolapse, 67.6%, were in the age group of 51-60 years. Out of 37 patients, 18.9% had a history of chronic cough secondary to bronchial asthma or past history of tuberculosis And 13.5% had a bowel dysfunction (chronic constipation). Vaginal vault prolapse most commonly was seen following vaginal hysterectomy (43.3%) as compared to total abdominal hysterectomy (29.7%). Most common surgery was performed for post-hysterectomy vault prolapse being sacrospinous fixation in the current study. In total, 29.7% of the patients had early post-operative complications like urinary tract infection (16.2%), urinary retention (5.4%) and buttock pain (5.4%), and 2.7% had vaginal cuff cellulitis. Dyspareunia is a common complication post-operatively following sacrospinous fixation, due to shortening of vaginal length post-procedure.

Conclusion: Only 29.7% patients had complications, among which most common complication was urinary tract infection, which was treated with injectable antibiotics, urinary retention and buttock pain being the less common complication. Dyspareunia was present only in 18.9% cases post-operatively due to vaginal shortening associated with the procedure. Sacrospinous fixation is a safe and effective procedure.

Supplementary information: The online version contains supplementary material available at 10.1007/s13224-023-01757-9.

研究目的:研究选定组患者阴道拱顶脱垂的流行病学和各种修复方法,以及各种治疗模式在治疗拱顶脱垂中的益处。方法:37例lll级或lV级拱顶脱垂患者纳入我们的研究。对37例患者进行了骶管内固定。对脱垂的高危因素、手术结果和并发症进行了评估。结果:在目前的研究中,最大的跳马脱垂病例(67.6%)发生在51-60岁的年龄组。在37名患者中,18.9%有继发于支气管哮喘的慢性咳嗽史或既往肺结核史,13.5%有肠功能障碍(慢性便秘)。与全腹子宫切除术(29.7%)相比,阴道拱顶脱垂最常见于阴式子宫切除术后(43.3%)。在本研究中,最常见的手术是对子宫切除后的拱顶脱垂进行骶棘固定。总的来说,29.7%的患者有术后早期并发症,如尿路感染(16.2%)、尿潴留(5.4%)和臀部疼痛(5.4%),2.7%的患者有阴道套蜂窝组织炎。由于骶棘固定术后阴道长度缩短,功能障碍是术后常见的并发症。结论:只有29.7%的患者出现并发症,其中最常见的并发症是尿路感染,注射抗生素治疗,尿潴留和臀部疼痛是不太常见的并发症。由于与手术相关的阴道缩短,术后仅18.9%的病例出现了偏瘫。骶管内固定是一种安全有效的手术方法。补充信息:在线版本包含补充材料,可访问10.1007/s13224-023-01757-9。
{"title":"Study of Post-hysterectomy Vault Prolapse and Surgical Management.","authors":"Hemangi J Kansaria, Tulika Chouhan","doi":"10.1007/s13224-023-01757-9","DOIUrl":"10.1007/s13224-023-01757-9","url":null,"abstract":"<p><strong>Purpose of study: </strong>To study the epidemiology and various methods of repair of vaginal vault prolapse in selected group of patients and the benefits of various modes of treatment in the management of vault prolapse.</p><p><strong>Methods: </strong>Thirty-seven patients with grade lll or lV vault prolapse were enrolled in our study. Sacrospinous fixation was performed in 37 patients. High risk factors for prolapse, surgical results and complications were evaluated.</p><p><strong>Results: </strong>In the current study, maximum cases of vault prolapse, 67.6%, were in the age group of 51-60 years. Out of 37 patients, 18.9% had a history of chronic cough secondary to bronchial asthma or past history of tuberculosis And 13.5% had a bowel dysfunction (chronic constipation). Vaginal vault prolapse most commonly was seen following vaginal hysterectomy (43.3%) as compared to total abdominal hysterectomy (29.7%). Most common surgery was performed for post-hysterectomy vault prolapse being sacrospinous fixation in the current study. In total, 29.7% of the patients had early post-operative complications like urinary tract infection (16.2%), urinary retention (5.4%) and buttock pain (5.4%), and 2.7% had vaginal cuff cellulitis. Dyspareunia is a common complication post-operatively following sacrospinous fixation, due to shortening of vaginal length post-procedure.</p><p><strong>Conclusion: </strong>Only 29.7% patients had complications, among which most common complication was urinary tract infection, which was treated with injectable antibiotics, urinary retention and buttock pain being the less common complication. Dyspareunia was present only in 18.9% cases post-operatively due to vaginal shortening associated with the procedure. Sacrospinous fixation is a safe and effective procedure.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13224-023-01757-9.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"124-129"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction Models for Adverse Pregnancy Outcomes in India: Methodological Considerations for an Emerging Topic. 印度不良妊娠结局的预测模型:一个新兴主题的方法论考虑。
IF 0.7 Q3 Medicine Pub Date : 2023-10-01 Epub Date: 2022-03-10 DOI: 10.1007/s13224-021-01617-4
Gavin Pereira

Stillbirth is over-represented in lower and lower-middle-income countries and understandably this has motivated greater research investment in the development of prediction models. Prediction is particularly challenging for pregnancy outcomes because only part of the population is represented in observational research. Notably, unrecognised pregnancies and miscarriages are typically excluded from the development of prediction models and the consequences of such selection are not well understood. Other methodological challenges in developing stillbirth prediction models are within the control of the researcher. Identifying whether the intended model is for aetiological explanation versus prediction, attainment of a sufficiently large representative sample, and internal and external validation are among such methodological considerations. These considerations are discussed in relation to a recently published study on prediction of stillbirth after 28 weeks of pregnancy for women with hypertensive disorders of pregnancy in India. The predictive ability of this model amounts to the flip of a coin. Future screening based on such a model may be expensive, increase psychological distress among patients and introduce additional iatrogenic perinatal morbidities from over-treatment. Future research should address the methodological considerations described in this article.

死产在中低收入国家的比例过高,可以理解的是,这促使人们在开发预测模型方面加大了研究投资。预测妊娠结局尤其具有挑战性,因为观察性研究只代表了一部分人群。值得注意的是,未被识别的妊娠和流产通常被排除在预测模型的开发之外,而且这种选择的后果还不太清楚。开发死胎预测模型的其他方法学挑战也在研究人员的控制范围内。确定预期模型是否用于病因解释与预测、获得足够大的代表性样本以及内部和外部验证都是这些方法论考虑因素。这些考虑因素与最近发表的一项研究有关,该研究预测了印度妊娠期高血压疾病妇女怀孕28周后的死胎。这个模型的预测能力相当于硬币的翻转。基于这种模式的未来筛查可能代价高昂,会增加患者的心理困扰,并因过度治疗而导致额外的医源性围产期疾病。未来的研究应该解决本文中描述的方法论考虑因素。
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引用次数: 0
Impact of Action Taken in Response to Stillbirth Audit: A Success Story. 应对死产审计行动的影响:一个成功的故事。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-08-23 DOI: 10.1007/s13224-023-01808-1
Manisha Kumar, Manju Puri, Millo Suka, Nupur Chawla, Gagan Preet Kaur, Reena Yadav, Kiran Agrawal, Ratna Biswas

Objectives: Study the impact of intra-facility interventions on the modifiable factors causing stillbirths (SB), using point-of-care quality improvement (POCQI) methodology.

Material and methods: Stillbirth data during the 9 months pre-intervention period were reviewed to identify the common preventable causes. Two interventions, namely, ultrasound at 34-36 weeks gestation and intrapartum monitoring on a common customized labor chart for all health-care providers, were done. Post-intervention data were collected to observe the impact of the interventions.

Results: The stillbirth rate reduced from 212/5940 deliveries (35.7/1000) in the pre-intervention period to 165/5993 deliveries (27.7/1000) in the post-intervention period (p = 0.011). The intra-facility failure to identify FGR significantly reduced in the post-intervention group (p = 0.033), leading to 63% (RR 0.37) reduction in its risk. Using a common customized labor chart led to a significant decline in the inadequate monitoring as a provider-related cause of stillbirth (p < 0.001) leading to its 42% decline as contributor to modifiable cause of SB (RR 0.48).

Conclusion: Reviewing the perinatal death surveillance response (PDSR) data, identifying gaps in care, and using improvement methodology for instituting corrective measures play an important role in reducing intramural stillbirths.

目的:使用护理质量改进点(POCQI)方法,研究机构内干预对导致死产(SB)的可改变因素的影响。材料和方法:回顾干预前9个月的死产数据,以确定常见的可预防原因。进行了两项干预措施,即妊娠34-36周时的超声检查和在所有医疗保健提供者的通用定制分娩图上进行产时监测。收集干预后的数据,观察干预措施的影响。结果:死产率从干预前的212/5940次分娩(35.7/1000)降至干预后的165/5593次分娩(27.7/1000)(p = 0.011)。在干预后组中,识别FGR的设施内失败显著减少(p = 0.033),导致其风险降低63%(RR 0.37)。使用常见的定制分娩图表导致作为提供者相关死产原因的监测不足显著下降(p 结论:回顾围产期死亡监测反应(PDSR)数据,找出护理差距,并使用改进方法制定纠正措施,在减少壁内死产方面发挥着重要作用。
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引用次数: 0
Prevalence of P16 Immunohistochemistry Positive Staining and Its Correlation to Clinical and Radiological Staging of Squamous Cell Carcinoma of the Cervix. 宫颈鳞状细胞癌P16免疫组化阳性染色的患病率及其与临床和放射学分期的相关性。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-10-01 Epub Date: 2023-06-28 DOI: 10.1007/s13224-023-01772-w
Hossam H El Sokkary, Eman Sheta
<p><strong>Background: </strong>Cervical cancer is the fourth most common genital tract cancer and fourth common cause of death among the causes of neoplasm-related mortality in women worldwide. Squamous cell carcinoma is the most common type and constitutes about 90% of all pathological types of cervical cancer. Cyclin-dependent kinase inhibitor 2A (CDKN2A; p16) is a gene that is located on chromosome 9 that encodes a protein (P16) that inhibits cyclin-dependent kinases 4 and 6 which are inhibitors of retinoblastoma protein; the net result is reactivation of retinoblastoma protein and arrest of cell cycle in G1 phase. So, expression of p16 protein within cancer cell may denote good prognosis. The presence of a soft marker that can detect hidden advanced stages in apparently clinically and radiologically early resectable stages of cervical cancer and can replace life-threatening preoperative lymphadenectomy is of great importance. Is P16 protein which when expressed is associated with good prognosis in other cancer can be this soft marker?</p><p><strong>Aim of the study: </strong>The aim of this study is to estimate the prevalence of cyclin-dependent kinase inhibitor 2A (CDKN2A; p16) immunohistochemistry positive staining in squamous cell carcinoma of the cervix and to correlate its positivity  to clinical and radiological disease stage.</p><p><strong>Patients and methods: </strong>An analytical cross-sectional observational prospective and retrospective study was conducted on 60 invasive squamous cell cervical cancer patients from gyne-oncology unit at Al Shatby university hospital after taking a written consent and following approval by Alexandria medical school institutional ethics committee. Inclusion criteria included all patients with invasive squamous cell carcinoma of the cervix prospective and retrospective from January 2019 till June 2022 diagnosed by taking wedge, punch and cone biopsy followed by histopathological examination that confirmed the diagnosis and showed grading and types of squamous cell carcinoma. Clinical examination, vaginal ultrasonographic scanning, computerized axial tomography and magnetic resonance imaging were carried out to all cases, and data were recorded for clinical and radiological staging purposes. All data were collected, coded, tabulated and statistically analyzed to estimate the prevalence of p16 positivity in the study cases and to correlate its positivity with clinical and radiological disease stage.</p><p><strong>Result: </strong>In relation to prevalence of p16 immunostaining, 34 cases (56.7%) were positive in comparison with 26 cases (43.3%) being negative. Considering correlation between early resectable stage and late nonresectable stage with P16 positive and negative staining, the result showed the following: 32 cases (53.3%) were resectable, 30 cases (88.2%) of them were P16 positive immunostaining compared to 2 cases (7.7%) being P16 negative immunostaining while nonresectable cases were 28 cas
背景:癌症是全球女性肿瘤相关死亡率中第四大最常见的生殖道癌症,也是第四大常见死亡原因。鳞状细胞癌是最常见的类型,约占癌症所有病理类型的90%。细胞周期蛋白依赖性激酶抑制剂2A(CDKN2A;p16)是位于9号染色体上的基因,其编码抑制作为视网膜母细胞瘤蛋白抑制剂的细胞周期蛋白激酶4和6的蛋白(p16);最终结果是视网膜母细胞瘤蛋白的再激活和细胞周期在G1期的停滞。因此,p16蛋白在癌症细胞中的表达可能预示着良好的预后。一种软标记物的存在,可以在明显的临床和放射学早期可切除的宫颈癌症阶段发现隐藏的晚期,并可以取代危及生命的术前淋巴结切除术,这是非常重要的。在其他癌症中表达与良好预后相关的P16蛋白是否可以是这种软标志物?研究目的:本研究的目的是评估细胞周期蛋白依赖性激酶抑制剂2A(CDKN2A;p16)免疫组织化学阳性染色在宫颈鳞状细胞癌中的患病率,并将其阳性与临床和放射学疾病分期相关联。患者和方法:在取得书面同意并经亚历山大医学院机构伦理委员会批准后,对Al Shatby大学医院妇科肿瘤科的60名侵袭性鳞状细胞宫颈癌症患者进行了分析性横断面观察性前瞻性和回顾性研究。纳入标准包括2019年1月至2022年6月期间前瞻性和回顾性的所有宫颈浸润性鳞状细胞癌患者,通过楔形、穿孔和锥形活检进行诊断,然后进行组织病理学检查,确认诊断并显示鳞状细胞癌的分级和类型。对所有病例进行了临床检查、阴道超声扫描、计算机轴向断层扫描和磁共振成像,并记录了用于临床和放射学分期的数据。对所有数据进行收集、编码、制表和统计分析,以估计研究病例中p16阳性的患病率,并将其阳性率与临床和放射学疾病分期相关联。结果:p16免疫染色阳性34例(56.7%),阴性26例(43.3%)。考虑到P16阳性和阴性染色在早期可切除期和晚期不可切除期之间的相关性,结果显示:32例(53.3%)可切除,其中30例(88.2%)P16阳性,2例(7.7%)P16阴性,28例(46.7%)不可切除,4例(11.8%)P16阳性,24例(92.3%)P16免疫染色阴性,因此大多数早期可切除病例为P16阳性免疫染色,大多数晚期不可切除病例均为P16阴性免疫染色。P16免疫染色阳性与早期可切除分期呈正相关,P16免疫阴性与晚期无切除分期呈正相关性(p = 结论:P16蛋白在宫颈鳞状细胞癌中的阳性表达率为56.7%,其阳性表达与早期可切除的临床和放射学疾病分期高度相关。
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引用次数: 0
Voices from Health Care Providers: Assessing the Impact of the Indian Assisted Reproductive Technology (Regulation) Act, 2021 on the Practice of IVF in India. 来自卫生保健提供者的声音:评估2021年印度辅助生殖技术(管理)法对印度试管婴儿实践的影响。
IF 0.7 Q3 Medicine Pub Date : 2023-08-01 DOI: 10.1007/s13224-023-01815-2
Jaydeep Tank, Prabha Kotiswaran, Parikshit Tank, Dev Tank, Jash Tank

The regulatory vacuum in the field of ART in India was filled when in December 2021, the Assisted Reproductive Technology (Regulation) Act, 2021 (ART Act) (https://egazette.nic.in/WriteReadData/2021/232025.pdf) and the Surrogacy (Regulation) Act, 2021 (SR Act) were passed. We surveyed medical professionals to understand their knowledge, attitude and perception towards the Acts and to offer an initial, snapshot assessment of their impact on the medical community. The government has already signalled its intent to implement the Acts and has published several notifications/gazettes to clarify and amend the issues surrounding the Acts (https://artsurrogacy.gov.in/NationalArtSurrogacy/faces/HomePage.xhtml#). We hope that these responses will help to voice the thoughts, concerns and suggestions from of ART service providers for ART to further clarify and rationalise the laws. Infertility is already a much stigmatised problem which deserves to be a higher public health priority. While the laws are a welcome step, changes in both laws is are the need of the hour to make ART more accessible, available and affordable to the millions of couples who need these services and for the health care providers who to be able to deliver them.

2021年12月,通过了《2021年辅助生殖技术(管理)法案》(ART法案)(https://egazette.nic.in/WriteReadData/2021/232025.pdf)和《2021年代孕(管理)法案》(SR法案),填补了印度ART领域的监管真空。我们对医疗专业人员进行了调查,以了解他们对这些法案的知识、态度和看法,并对这些法案对医学界的影响进行初步、简要的评估。政府已经表示有意实施这些法案,并发布了几份通知/宪报,以澄清和修订有关法案的问题(https://artsurrogacy.gov.in/NationalArtSurrogacy/faces/HomePage.xhtml#)。我们希望这些回应能有助表达抗逆转录病毒服务提供者对抗逆转录病毒治疗的想法、关注和建议,以进一步厘清和理顺法律。不孕症已经是一个备受诟病的问题,理应成为公共卫生的优先事项。虽然这两项法律是值得欢迎的一步,但这两项法律的变化是使数百万需要这些服务的夫妇和能够提供这些服务的卫生保健提供者更容易获得、获得和负担得起抗逆转录病毒治疗的迫切需要。
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引用次数: 0
Elective Single Cleavage-Stage Embryo Transfer in IVF Patients with Suboptimal Ovarian Response is Not Detrimental to Cumulative Pregnancy and Reduces Multiple Pregnancy Rates. 对卵巢反应不佳的试管婴儿患者进行选择性单裂期胚胎移植不会影响累积妊娠率并降低多胎妊娠率。
IF 0.7 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2023-08-01 Epub Date: 2023-06-07 DOI: 10.1007/s13224-023-01768-6
Alessio Paffoni, Sabrina Cesana, Laura Corti, Hilda Wyssling, Alessandro Kunderfranco, Marco Claudio Bianchi

Purpose: To evaluate whether elective single embryo transfer in patients with suboptimal response to ovarian stimulation is detrimental to pregnancy rates compared to double embryo transfer.

Methods: A case-control retrospective study was performed in a cohort of couples undergoing IVF at the Infertility Unit of the ASST Lariana with ≤ 9 oocytes and at least 2 viable embryos. A total of 424 women were analyzed in the "double embryo transfer" group (n = 212) and elective "single embryo transfer" group (n = 212); they were matched 1:1 for female age, ovarian reserve and number of previous cycles. Cumulative clinical pregnancy rate per oocyte retrieval was the main outcome.

Results: The cumulative pregnancy rate per cycle, including the fresh embryo and subsequent frozen embryo transfers, was 26% and 26%, respectively. Considering the main confounding factors, a binomial logistic model indicated that the cumulative clinical pregnancy rate was not significantly affected when a single embryo transfer was performed in women recovering up to nine oocytes.

Conclusion: Live birth rate was similar between the two groups, while twin pregnancies were significantly reduced in women receiving single embryo transfer suggesting that elective single embryo transfer in patients with a limited number of embryos is not detrimental to pregnancy rates.

目的:与双胚胎移植相比,评估对卵巢刺激反应不理想的患者选择单胚胎移植是否不利于妊娠率:一项病例对照回顾性研究的对象是在拉里亚纳不孕症中心接受体外受精的夫妇群,这些夫妇的卵母细胞数不超过9个,且至少有2个可存活的胚胎。共对 424 名妇女进行了分析,分为 "双胚胎移植 "组(n = 212)和选择性 "单胚胎移植 "组(n = 212);这两组妇女的年龄、卵巢储备和前几个周期的次数均为 1:1。主要结果是每次取卵的累积临床妊娠率:每个周期的累积妊娠率(包括新鲜胚胎移植和随后的冷冻胚胎移植)分别为 26% 和 26%。考虑到主要的混杂因素,二项Logistic模型显示,对于最多取回9个卵母细胞的妇女来说,如果进行单次胚胎移植,累积临床妊娠率不会受到显著影响:结论:两组患者的活产率相似,而接受单胚胎移植的女性双胎妊娠率明显降低,这表明对胚胎数量有限的患者进行选择性单胚胎移植不会对妊娠率产生不利影响。
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引用次数: 0
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Journal of Obstetrics and Gynecology of India
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