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Acute RV Failure Management in Pulmonary Embolism 肺栓塞的急性右心室衰竭处理
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-06-01 DOI: 10.1016/j.tvir.2025.101039
Naina Verma MD , Vishaal Kondoor MBA , Rajshree Singh MD , Rakesh Ahuja MD
Acute right ventricular (RV) failure significantly influences mortality rates in patients experiencing pulmonary embolism (PE). This condition arises from an abrupt increase in RV afterload triggered by clot burden, neurohormonal activation, and hypoxia-mediated feedback mechanisms. The ensuing pathological cascade results in RV dilation, decreased stroke volume, and compromised left ventricular (LV) filling due to interventricular dependence, which can lead to hemodynamic collapse. This paper elucidates management strategies focusing on preload optimization, early clot removal through thrombolytic therapy or thrombectomy, and the judicious use of vasopressors and inotropes to sustain systemic blood pressure, enhance coronary perfusion, and maintain RV-LV coupling. In cases of respiratory failure, mechanical ventilation must be utilized with caution. At the same time, advanced interventions such as extracorporeal membrane oxygenation (ECMO) or RV assist devices are reserved for more severe scenarios. A comprehensive understanding of RV physiology and the pathophysiology of PE is essential for devising early interventions aimed at averting the “RV death spiral” and enhancing patient outcomes. Timely recognition and aggressive management are foundational to treating acute RV failure in PE effectively. Acute right ventricular failure is a critical pathology observed in patients suffering from pulmonary embolism. The significance of understanding the underlying mechanisms of RV failure, particularly concerning PE, cannot be overstated, as it is a crucial determinant of morbidity and mortality. The development of acute RV failure is primarily precipitated by a sudden escalation in RV afterload, a consequence of the obstruction of pulmonary arteries by embolic material. This obstruction induces neurohormonal activation and triggers feedback mechanisms associated with hypoxia, leading to the aforementioned detrimental cascade. The resultant RV dilation and diminished stroke volume adversely affect LV filling due to the phenomenon of interventricular dependence, ultimately paving the way for hemodynamic instability. A nuanced understanding of RV physiology alongside the pathophysiological mechanisms underlying pulmonary embolism is imperative for developing and implementing timely interventions. Early recognition and an aggressive management approach are vital to prevent the “RV death spiral” and improve clinical outcomes for patients confronting acute RV failure in the context of pulmonary embolism.
急性右心室(RV)衰竭显著影响肺栓塞(PE)患者的死亡率。这种情况是由血栓负荷、神经激素激活和缺氧介导的反馈机制引发的左心室后负荷突然增加引起的。随后的病理性级联导致左室扩张,卒中容量减少,以及由于室间依赖性导致的左室充盈受损,这可能导致血流动力学塌陷。本文阐述的管理策略侧重于负荷前优化,通过溶栓治疗或取栓来早期清除血栓,以及明智地使用血管加压药和收缩药物来维持全身血压,增强冠状动脉灌注,维持左室-左室耦合。在呼吸衰竭的情况下,必须谨慎使用机械通气。同时,先进的干预措施,如体外膜氧合(ECMO)或RV辅助装置,是为更严重的情况保留的。全面了解右心室生理学和PE的病理生理学对于设计旨在避免“右心室死亡螺旋”和提高患者预后的早期干预措施至关重要。及时认识和积极处理是有效治疗肺心病急性右心室衰竭的基础。急性右心室衰竭是肺栓塞患者的重要病理。了解右心室衰竭的潜在机制,特别是与PE相关的机制的重要性不能被夸大,因为它是发病率和死亡率的关键决定因素。急性右心室衰竭的发展主要是由右心室后负荷的突然增加引起的,这是肺动脉被栓塞物质阻塞的结果。这种阻塞诱导神经激素激活并触发与缺氧相关的反馈机制,导致上述有害的级联反应。由于室间依赖现象,由此导致的左室扩张和卒中容量减少对左室充盈产生不利影响,最终为血流动力学不稳定铺平了道路。细致入微地了解右心室生理学以及肺栓塞的病理生理机制对于制定和实施及时的干预措施是必不可少的。早期识别和积极的治疗方法对于预防“右心室死亡螺旋”和改善肺栓塞患者急性右心室衰竭的临床结果至关重要。
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引用次数: 0
ECMO, VAD, Impella, and IABP: Primer on Mechanical Circulatory Support Devices ECMO, VAD, Impella和IABP:机械循环支持装置入门
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-06-01 DOI: 10.1016/j.tvir.2025.101042
Jonas Kruse MD , Mona Ranade MD
Vascular and interventional physicians are routinely caring for some of the sickest patients in the hospital, including those with cardiopulmonary collapse. A foundational comprehension of mechanical circulatory devices is necessary in these situations. Within this article, we will review the indications, procedural steps, management, clinical follow up, and outcomes of 4 types of mechanical circulatory support devices: Extracorporeal membrane oxygenation (ECMO), ventricular assist devices (VAD), Impella, and intra-aortic balloon pumps (IABP). ECMO is a large-bore cannulation system serving patients in respiratory and/or combination of cardiorespiratory collapse. It requires constant monitoring and adjustment with a wide range of benefits in appropriately selected patients in the hospital. VADs are surgically-implanted devices for more long-term ventricular support, often extending the survival of end-stage heart failure or bridging to transplant. Impella and IABPs, by comparison, are smaller intravascular devices that aid in short-term ventricular off-loading and improve perfusion. They provide hemodynamic stabilization in the setting of acute cardiac insult or surgery, prior to either organ recovery or transition to more definitive therapy. All of these devices come with unique considerations and potential complications. This article will serve as a guide in evaluating patients for device candidacy, procedural placement, troubleshooting, management in the perioperative setting, complication surveillance, and clinical outcomes/follow-up.
血管和介入内科医生通常要照顾医院里一些病情最严重的病人,包括那些心肺衰竭的病人。在这些情况下,对机械循环装置的基本理解是必要的。在本文中,我们将回顾4种机械循环支持装置的适应症、程序步骤、管理、临床随访和结果:体外膜氧合(ECMO)、心室辅助装置(VAD)、Impella和主动脉内球囊泵(IABP)。ECMO是一种大口径插管系统,服务于呼吸和/或合并心肺衰竭的患者。它需要对医院中适当选择的患者进行持续监测和调整,并带来广泛的益处。vad是手术植入的装置,用于更长期的心室支持,通常延长终末期心力衰竭患者的生存期或为移植搭建桥梁。相比之下,Impella和IABPs是更小的血管内装置,有助于短期心室卸载和改善灌注。它们在急性心脏损伤或手术的情况下提供血流动力学稳定,在器官恢复或过渡到更明确的治疗之前。所有这些设备都有独特的考虑和潜在的并发症。本文将作为评估患者设备候选性、程序放置、故障排除、围手术期管理、并发症监测和临床结果/随访的指南。
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引用次数: 0
Anesthesia and Analgesia for Interventional Radiology 介入放射学的麻醉与镇痛
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-06-01 DOI: 10.1016/j.tvir.2025.101037
Abram Feldman MD
To perform procedures in the interventional radiology suite, patient comfort and tolerance must be ensured through appropriate anesthesia and analgesia. Various levels of anesthesia can be utilized to safely accomplish a procedure from local anesthesia and mild sedation to general anesthesia. Depending on patient and procedural factors, different anesthetic plans may be beneficial. Patient factors such as chronic pain, hemodynamic stability, and complex medical problems will likely benefit from anesthesiologist involvement in the procedure. Procedural factors such as specific positioning requirements, following instructions, or invasiveness of the procedure may dictate what level of anesthesia is required, as well. Various anesthetic agents are used for amnesia, anesthesia, analgesia, and muscle relaxation. Understanding patients’ needs and procedural requirements will aid a clinician in performing safe and effective interventional procedures and maintain safety – from preoperative evaluation and monitoring during the procedure to discharging from the recovery room.
为了在介入放射室进行手术,必须通过适当的麻醉和镇痛来确保患者的舒适和耐受性。从局部麻醉和轻度镇静到全身麻醉,可以使用不同程度的麻醉来安全地完成手术。根据病人和手术因素,不同的麻醉方案可能是有益的。患者因素,如慢性疼痛、血流动力学稳定性和复杂的医疗问题可能会受益于麻醉医生参与手术。手术过程中的一些因素,如特定的体位要求、遵循指示或手术的侵入性,也可能决定需要何种程度的麻醉。各种麻醉剂用于健忘症、麻醉、镇痛和肌肉松弛。了解患者的需求和程序要求将有助于临床医生实施安全有效的介入手术,并保持从术前评估和手术期间的监测到出院的安全。
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引用次数: 0
Evaluation and Initial Stabilization of Undifferentiated Shock 未分化冲击的评价与初始稳定
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-06-01 DOI: 10.1016/j.tvir.2025.101038
Bardia Nadim MD , Alexandria Z. Byskosh MD , Khanant M. Desai MD, RPVI
Vascular Interventional Radiologists (VIRs) are increasingly involved in consultation and management of patients with circulatory shock. The ability to recognize the underlying pathophysiology of a patient’s shock and treat appropriately is therefore critical to VIR practice. Here, we discuss the initial evaluation and stabilization of undifferentiated shock. Shock is defined as tissue hypoperfusion from inadequate oxygen delivery and/or impaired tissue oxygen utilization. The etiologies of shock can be grouped into 3 main categories: distributive, hypovolemic, cardiogenic, and obstructive; each of which are associated with characteristic hemodynamic and metabolic derangements such as decreased preload or impaired cardiac contractility. Presentation typically involves 1) hypotension and tachycardia as indicators of impaired cardiac output, and 2) evidence of ongoing end-organ hypoperfusion such as oliguria, altered mental status, and lactic acidosis. Initial management includes control of airway and oxygenation/ventilation, identification of underlying hemodynamic and cardiovascular derangements, and support of cardiac output with intravenous fluid (IVF), blood products, diuresis, and/or vasopressors and inotropes. More detailed hemodynamic analysis can be performed with arterial catheters, blood gases, pulmonary artery catheters, and echocardiography to further tailor therapy. Finally, definitive evaluation for causative etiology should be initiated immediately with biochemical studies, cultures, imaging, and hemodynamic assessment so that etiology-specific treatment (e.g. antibiotics, blood products) can be initiated.
血管介入放射科医师(VIRs)越来越多地参与到循环休克患者的咨询和管理中。因此,识别患者休克的潜在病理生理学并进行适当治疗的能力对VIR实践至关重要。在这里,我们讨论了未分化冲击的初步评估和稳定。休克的定义是由于氧气输送不足和/或组织氧气利用受损造成的组织灌注不足。休克的病因可分为3大类:分布性、低血容量性、心源性和梗阻性;每一种都与特征性血流动力学和代谢紊乱有关,如预负荷降低或心脏收缩性受损。典型的表现包括:1)低血压和心动过速,作为心输出量受损的指标;2)持续的终末器官灌注不足的证据,如少尿、精神状态改变和乳酸性酸中毒。最初的治疗包括控制气道和氧合/通气,识别潜在的血液动力学和心血管紊乱,并通过静脉输液(IVF)、血液制品、利尿和/或血管加压药和收缩药物支持心输出量。更详细的血流动力学分析可以通过动脉导管、血气、肺动脉导管和超声心动图进行,以进一步定制治疗。最后,应立即通过生化研究、培养、影像学和血流动力学评估对病因进行明确评估,以便开始针对病因的治疗(如抗生素、血液制品)。
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引用次数: 0
Focused Cardiac Ultrasound for Rapid Hemodynamic Assessment: A Primer for Vascular and Interventional Radiologists 聚焦心脏超声快速血流动力学评估:血管和介入放射科医师入门
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101025
Khanant M. Desai MD, RPVI
Interventional Radiology has evolved to encompass periprocedural and inpatient care of critically ill patients. Acute hypotension and shock can occur in IR patients due to various causes including hemorrhage, sepsis, myocardial infarction, and pulmonary embolism; therefore, the ability to accurately evaluate acutely deteriorating patients must become a part of the IR skillset. Goal-directed sonographic examination of the heart and inferior vena cava provides rapid bedside assessment of anatomic and functional parameters that can be used to determine the etiology underlying a patient's shock. Targets of evaluation include ventricular systolic function/size/thickness, presence of pericardial effusion and tamponade physiology, intravascular volume status, and existence of other structural pathology such as valvular disease and intracardiac masses. Presented is a primer on performing a systematic focused cardiac ultrasound examination for patients experiencing acute hypotension.
介入放射学已经发展到包括危重病人的围手术期和住院护理。IR患者可因出血、败血症、心肌梗死、肺栓塞等多种原因发生急性低血压和休克;因此,准确评估急性恶化患者的能力必须成为IR技能的一部分。心脏和下腔静脉的目标定向超声检查提供了快速的床边解剖和功能参数评估,可用于确定患者休克的病因。评估的目标包括心室收缩功能/大小/厚度、心包积液和心包填塞的存在、血管内容积状况以及其他结构性病理(如瓣膜疾病和心内肿块)的存在。提出的是执行系统集中心脏超声检查的初级入门患者经历急性低血压。
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引用次数: 0
Fluid Status Assessment and the Role of the Venous Excess Ultrasound (VExUS) Score 静脉超声(VExUS)评分对液体状态的评估和作用
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101026
Andrew R. Ahn MD, Khanant M. Desai MD, RPVI
Interventional radiologists frequently assume care of patients with high severity of acute and chronic illnesses, many of which can contribute to shock and organ failure in the inpatient setting. The ability to quickly assess the hemodynamic status of a decompensating patient at bedside is therefore a valuable skill for IRs to develop. Assessment of intravascular volume status is fundamental to this—shock and organ failure are commonly precipitated by hypovolemia resulting in decreased circulating blood volume and organ perfusion, but may also develop due to fluid overload resulting in heart failure and organ malperfusion due to venous congestion. The venous excess ultrasound (VExUS) protocol is a rapid point-of-care sonographic exam that scores severity of systemic venous congestion by integrating analysis of multiple venous beds. Here, we review traditional methods of estimating intravascular volume status, technical aspects of the VExUS examination, interpretation of VExUS results, and practical applications for VExUS.
介入放射科医生经常要照顾患有严重急性和慢性疾病的病人,其中许多病人在住院时可能会导致休克和器官衰竭。因此,在床边快速评估失代偿患者的血流动力学状态的能力是IRs需要培养的一项宝贵技能。评估血管内容量状态是这方面的基础——休克和器官衰竭通常是由低血容量导致循环血容量和器官灌注减少引起的,但也可能是由于液体超载导致心力衰竭和器官灌注不良引起的静脉充血。静脉充血超声(VExUS)方案是一种快速的即时超声检查,通过综合分析多个静脉床来评分全身静脉充血的严重程度。在这里,我们回顾了估算血管内容积状态的传统方法、VExUS检查的技术方面、对VExUS结果的解释以及VExUS的实际应用。
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引用次数: 0
Corrigendum to Image guided percutaneous robotic interventions for solid organs Techn Vasc Intervent Radiol (TVIR). 2024, 27: 101006 图像引导的实体器官经皮机器人介入技术血管介入放射(TVIR)的勘误表。2024, 27: 101006
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101019
Govindarajan Narayanan MD , Ripal T. Gandhi MD , Matheus A. Dabus , Bente A.T. van den Bemd MD
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引用次数: 0
Central Venous Recanalization and Right Atrial Thrombectomy Using IVUS 中心静脉再通及右房血栓取栓术
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101024
Rehan Syed Quadri MD
Central venous occlusions (CVOs) of the systemic circulation are highly morbid, causing significant symptoms from venous congestion, venous thromboembolism (VTE) and impaired vascular access. Endovascular recanalization (EVR) has emerged as the treatment of choice for medically refractory nonthrombotic and thrombotic CVOs with Intravascular Ultrasound (IVUS) playing a pivotal role. Radial and side-firing IVUS catheters are used during central venous recanalization in the chest, abdomen and pelvis. The intraluminal ultrasonic view of a CVO shows dynamic details of pathology not obtained with conventional venography or cone-beam CT, allowing for a more accurate evaluation of clot burden, wall integrity, tumor invasion, occlusion length and luminal caliber. IVUS is also superb for guiding treatment of CVOs involving blunt and sharp recanalization, stenting, and mechanical thromboembolectomy (MTE) of VTE, especially high-risk free-floating thrombi (FFT) and clot in-transit (CIT) in the right atrium (RA). It most accurately assesses procedural endpoints, including successful intravascular traversal across an occlusion, adequate luminal gain after venoplasty and stenting, and complete clot extraction during thrombectomy. Moreover, this is all done without added contrast or radiation, which is paramount to reduce exposure during a challenging recanalization, especially in the aging hemodialysis population. Long-term data is now available that shows IVUS can enhance technical and clinical success and reduce complications during EVR. To achieve these benefits with IVUS interventionalists must be familiar with the available catheters and how to optimize and interpret the intraluminal images obtained. This paper will review the patient evaluation, indications, equipment, steps, challenges, complications, and outcomes for central venous recanalization (CVR) and RA thrombectomy with IVUS.
体循环中心静脉闭塞(CVOs)是高度病态的,引起静脉充血、静脉血栓栓塞(VTE)和血管通路受损等显著症状。血管内再通术(EVR)已成为医学上难治性非血栓性和血栓性CVOs的治疗选择,血管内超声(IVUS)起着关键作用。在胸部、腹部和骨盆的中心静脉再通中使用径向和侧射IVUS导管。CVO的腔内超声图像显示了常规静脉造影或锥束CT无法获得的病理动态细节,可以更准确地评估血块负荷、管壁完整性、肿瘤侵袭、闭塞长度和管腔口径。IVUS对于包括钝性和尖锐再通、支架植入术和VTE机械血栓栓塞切除术(MTE)在内的CVOs,特别是右心房(RA)的高风险自由漂浮血栓(FFT)和转运血栓(CIT)的指导治疗也是极好的。它最准确地评估手术终点,包括成功通过闭塞的血管内穿越,静脉成形术和支架植入后足够的管腔增益,以及在取栓过程中完全取出血块。此外,所有这些都是在没有添加造影剂或辐射的情况下完成的,这对于减少在具有挑战性的再通期间的暴露是至关重要的,特别是在老年血液透析人群中。目前可获得的长期数据表明,IVUS可提高技术和临床成功率,并减少EVR期间的并发症。为了实现IVUS的这些好处,介入医师必须熟悉可用的导管以及如何优化和解释所获得的腔内图像。本文将回顾中心静脉再通术(CVR)和静脉血栓切除术(IVUS)的患者评估、适应症、设备、步骤、挑战、并发症和结果。
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引用次数: 0
Transvenous biopsy of abdominal-pelvic lesions with no safe percutaneous access: How we do it 无安全经皮通路的腹盆腔病变的经静脉活检:我们如何做
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101022
Akhilesh Pillai , Achintya A. Patel MD , Ankit Mehta MD , Moaz M. Choudhary MD
Recent developments in cancer genomics have allowed for comprehensive genomic profiling of tumors, thereby allowing oncologists to provide targeted therapies for patients with advanced cancers. This has made it even more important to obtain adequate core biopsies of lesions targeted for biopsies. While most lesions can be biopsied safely percutaneously using CT and ultrasound guidance, some lesions do not have a safe percutaneous window, thereby necessitating alternative biopsy techniques, such as transvenous biopsies, to aid in diagnosis and treatment. This review explores the use and technique of the transvenous approach for targeting small abdominal and pelvic masses using intravascular ultrasound guidance.
癌症基因组学的最新发展使肿瘤的全面基因组分析成为可能,从而使肿瘤学家能够为晚期癌症患者提供靶向治疗。这使得对活检的病灶进行充分的核心活检变得更加重要。虽然大多数病变可以使用CT和超声引导安全地经皮活检,但有些病变没有安全的经皮窗口,因此需要其他活检技术,如经静脉活检,以帮助诊断和治疗。本文综述了利用血管内超声引导经静脉入路治疗腹部和盆腔小肿块的方法和技术。
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引用次数: 0
Intravascular Ultrasound: A Review of Radial and Side Firing IVUS 血管内超声:桡骨和侧射IVUS的回顾
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.tvir.2025.101021
Aria Nazeri MD , Alexander Ushinsky MD , Sanjeeva P. Kalva MD , Moaz M. Choudhary MD
Intravascular ultrasound (IVUS) has become an essential tool for endovascular procedures, particularly during complex interventions. The benefits include improved visualization of vascular and extravascular anatomy, reduced complication rates, and enhanced accuracy during catheter-based interventions. In this review, we discuss the properties of side-firing (also commonly known as intracardiac echo ICE) and radial IVUS and explore their unique applications in endovascular procedures. The side-firing IVUS is advantageous for visualizing lesions and vascular structures in a plane parallel to the vessel wall, making it effective for guiding portal venous interventions, transvenous biopsies, and endoleak embolization, while the radial IVUS provides a 360-degree view of the vessel lumen, enabling detailed cross-sectional images of normal anatomy, pathologic processes requiring different endovascular therapy and their response to intervention(s).
血管内超声(IVUS)已成为血管内手术的重要工具,特别是在复杂的干预过程中。其好处包括改善血管和血管外解剖的可视化,降低并发症发生率,提高导管介入的准确性。在这篇综述中,我们讨论了侧射(也称为心内回声ICE)和径向IVUS的特性,并探讨了它们在血管内手术中的独特应用。侧射IVUS有利于在平行于血管壁的平面上观察病变和血管结构,使其有效地指导门静脉介入、经静脉活检和腔内栓塞,而径向IVUS提供血管腔的360度视图,使正常解剖、需要不同血管内治疗的病理过程及其对干预的反应的详细横断面图像成为可能。
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引用次数: 0
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Techniques in Vascular and Interventional Radiology
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