Ischemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strategy to control ischemic stroke. Here, a plasma kallikrein and active FXII (FXIIa) inhibitor (sylvestin, contained 43 amino acids, with a molecular weight of 4790.4 Da) was first identified from forest leeches (Haemadipsa sylvestris). Testing revealed that sylvestin prolonged activated partial thromboplastin time without affecting prothrombin time. Thromboelastography and clot retraction assays further showed that it extended clotting time in whole blood and inhibited clot retraction in platelet-rich plasma. In addition, sylvestin prevented thrombosis in vivo in FeCl3-induced arterial and carrageenan-induced tail thrombosis models. The potential role of sylvestin in ischemic stroke was evaluated by transient and permanent middle cerebral artery occlusion models. Sylvestin administration profoundly protected mice from ischemic stroke by counteracting intracerebral thrombosis and inflammation. Importantly, sylvestin showed no signs of bleeding tendency. The present study identifies sylvestin is a promising contact-kinin pathway inhibitor that can proffer profound protection from ischemic stroke without increased risk of bleeding.
Background: Perception of sexual harassment in informal relations is a largely uninvestigated topic. This study aimed to bridge this gap by examining the effect of the type of relationship between the perpetrator and the victim on the perception of harassment. Furthermore, we considered potential factors moderating the tested relationships: acceptance of gender stereotypes and sex.
Participants and procedure: In total, 369 participants were assigned to one of three conditions including a female victim and a male perpetrator who was either her neighbor, coworker, or supervisor.
Results: The participants assessed the harasser to be responsible. The supervisor's behavior was considered more punishable than that of the colleague or neighbor. The male participants reported that the perpetrator was less deserving of punishment than female participants.
Conclusions: The findings suggest that social norms regarding sexual harassment in formal and informal relationships are similar, excluding harassment by supervisors, which was rated as most punishable.

