Scientific Bulletin of the Omsk State Medical University最新文献

{"title":"Development of standard operating procedure \"Quality control of sodium chloride solution 0.9% (350 ml) for infusion (intra-pharmacy preparation) in pharmacy organizations manufacturing pharmaceuticals\"","authors":"A. V. Pereskok, I. A. Savchenko, I. Korneeva, E. A. Luksha, E. V. Ivanova, V. V. Podgurskaya","doi":"10.61634/2782-3024-2024-13-37-46","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-37-46","url":null,"abstract":"To develop a standard operating procedure (SOP) for quality control of 0.9% sodium chloride solution (350 ml) for infusion (intra-pharmacy preparation) in accordance with the requirements of the current regulatory documentation. Materials and Methods. Sodium chloride 0.9% sodium chloride solution (350 ml) for infusion (intra-pharmacy preparation) served as the object of the study. The SOP was developed taking into account the requirements of updated regulatory documents used in the field of quality control of medicines: Federal Law No. 61 dated 12.04.2010 \"On Circulation of Medicines\", Order of the Ministry of Health of the Russian Federation dated 22.05.2023 No. 249n, Order of the Ministry of Health of the Russian Federation dated 22.05.2023 No. 647n dated 31.08.2016, State Pharmacopoeia XV ed. and GOST R 52249-2009. Results. The main stages of the SOP in accordance with the current regulatory documentation are given, reagents, instruments and equipment required for testing are listed, mandatory and sample types of control are indicated. For this dosage form the mandatory controls will be organoleptic, written, control at release, physical and full chemical control. The methods of pH and authenticity tests are described, and the chemistry of qualitative reactions is given. For quantitative determination by the method of argentometry according to Mohr, the method of analysis is given, chemical reactions occurring during titration, the necessary calculations are made: the titer of silver nitrate solution of sodium chloride, the preliminary volume of titrant, the content of sodium chloride in the dosage form in grams. Permissible content limits are given in accordance with OFS.1.8.0001 \"Medicinal preparations of pharmacy manufacture\". Based on the results of the SOP development, a working instruction for quality control of sodium chloride solution 0.9% (350 ml) for infusion was drawn up. Conclusion. The presented SOP for quality control of sodium chloride solution 0.9% (350 ml) for infusion (intra-pharmacy preparation) describes the requirements for the organization and conditions of testing in assessing the quality of this dosage form and can be implemented in the work of manufacturing pharmacies as a detailed instruction for intra-pharmacy control.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of clabsi in oncologic hospitals","authors":"N. E. Belova, E. A. Wilms","doi":"10.61634/2782-3024-2024-13-47-53","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-47-53","url":null,"abstract":"Currently, healthcare-associated infections (HAIs) are one of the most dangerous complications for hospitalized patients. The economic damage caused by HCAI in the Russian Federation annually is about 15 billion rubles; in addition, HCAI occupy the tenth place among the causes of mortality of the population. Catheter-associated bloodstream infection holds the leading place in the structure of ISMP morbidity. The concept of CVC-AIC (catheter-associated bloodstream infections or CLABSI), in turn, is included in CAIC. Purpose of the study. To analyze the current literature data of domestic and foreign authors for the years 2012-2022 concerning CAIC in patients of oncologic hospitals with CVCs, including subcutaneous central venous port catheters. Material and Methods. A review of 38 literature sources for the last 10 years was performed, including current information on catheter-associated bloodstream infections, measures to prevent them, and modern treatment approaches. Results. The studies have shown that the combination of drug resistance in microorganisms and immunity reduction in cancer patients, which occurs against the background of chemotherapy, makes them a risk group for the development of CAICs and episodes of their recurrence. Ensuring epidemiological safety of bloodstream catheterization in such patients is an important step in the prevention of CAIC. This is one of the priority tasks of oncoepidemiology today. Conclusion. The leading role in the occurrence of catheter-associated bleeding plays the term of catheterization and the condition of the patient, his age, stage of cancer development and concomitant chronic diseases. One of the most vulnerable risk groups are cancer patients from hemoblastosis chemotherapy and bone marrow and hematopoietic stem cell transplantation units. This may be due to the use of immunosuppressant drugs to suppress graft rejection, which significantly reduce patients' immunity. According to the results of studies, infection with drug-resistant Gram-negative microorganisms, including multidrug-resistant ones, is prevalent in cancer patients with CAIC. When using povidone iodine, there is a tendency to decrease the incidence of CAIC, but the use of chlorhexidine alcohol solution showed better results. A direct correlation was observed between the use of surgically implanted intravascular devices for long-term function and a lower incidence of CAIC, particularly in pediatric oncology.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of ultrasonic diagnostics in the study of urogenital organs of birds","authors":"A. A. Dikikh, M. Pervenetskaya, V. V. Rusakov, L. I. Sukach, O. I. Slapovskaya, A. Komarov, Y. Makarova","doi":"10.61634/2782-3024-2024-13-30-36","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-30-36","url":null,"abstract":"Ultrasound examination is one of the most accessible and having a high probability of competence of research of diagnostics of diseases of internal organs, which are carried out mainly in small pets. The aim of the study is to obtain information about parenchymatous organs in birds in norm and in case of pathologic changes for making or confirming clinical diagnosis. Material and methods. Ultrasound diagnostics of avian oviduct was carried out on ultrasonic diagnostic scanner ETS-D-05 \"Raskan\", ~ 220V, 50 Hz, 100 VA, class 1. The transducer is microconvex 7.5 MHz. Results. At ultrasound examination of the kidneys in the chicken, it was noted that the kidneys had smooth, clear boundaries. The echostructure of cortical and brain layers in the median plane is heterogeneous, echogenicity of parenchyma corresponds to the norm. The capsule is not visualized. The presence of lighter and darker areas in the parenchyma is clearly visible, which is associated with filtration of mineral substances contained in the blood. Ultrasound examination of the genitalia in the chicken was carried out in several stages. At the first stage, the presence of a mature follicle was noted. Localized volumetric formations of rounded shape - follicles at different stages of development were revealed. They have homogeneous echogenicity and echostructure of hyperechogenic character, giving a weak acoustic shadow. In the second stage of the study we noted the presence of yolk covered with vitelline shell, which is located in the central part of the albumen section of the oviduct, has a high density and good echogenicity. In the third stage, the yolk is located in the caudal part of the albumen section. At its periphery, the albumen with several layers is located. Protein section is displaced somewhat to the left, has strongly tortuous loops. The wall of the albumen is well structured, the expression of layers is weakly marked. In the cavity of the oviduct, the content of the oviduct is homogeneous with a small amount of content of liquid consistency. At the fourth stage of the study in the uterus of the oviduct, an anechogenic formation - an egg - is visualized on the echogram. In its center, a hypoechogenic structure with indistinct contours - yolk is detected. The contours of the egg are smooth, borders are indistinct. The egg completely fills the uterine cavity, the lumen between the egg and the uterine wall is absent, the uterine wall contours are clear and even with homogeneous echogenic structure, no nodular formations are detected, uterine vessels are not dilated.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems of late radiation injuries of the skin and possibilities of their treatment","authors":"P. V. Bogdanchikova, M. V. Naboka","doi":"10.61634/2782-3024-2024-13-54-63","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-54-63","url":null,"abstract":"Currently there is a problem of insufficient effectiveness of treatment of late radiation skin lesions. Possibilities of application of combined schemes of treatment of malignant neoplasms, including radiation therapy, show both good immediate and distant results, life expectancy of patients has increased. However, the issue of such remote local radiation lesions as radiation ulcers also remains relevant. Such lesions in the practice of clinical oncologists usually occur from 1-1,5 months and more after the end of the course of close-focus X-ray therapy for skin cancer. The peculiarity of radiation ulcers is that they heal extremely poorly even by secondary tension. In the pathogenesis of late radiation ulcers, along with disruption of microcirculation, the main role is played by the direct damaging effect of radiation on stem cells and, consequently, suppression of reparative processes. For this reason, such ulcerous defects are characterized by torpidity to drug and surgical treatment. The analysis of modern scientific and practical literature does not fully reveal the peculiarities of the pathogenesis of post-radiation skin lesions leading to the development of radiation ulcers. Researchers have set a goal to search for new modern methods of effective treatment of this pathology. The main purpose of the literature review was to theoretically substantiate the possibilities of including enzyme antioxidants and epidermal growth factor preparations into the complex of pathogenetic treatment of radiation skin ulcers. Superoxide dismutase (SOD) is an active enzyme-antioxidant, it neutralizes excessive free oxygen radicals, and also has a pronounced anti-inflammatory effect by means of oxidative post-radiation stress of skin tissues. Epidermal growth factor promotes cell growth and differentiation of stem cells (SC) involved in ulcer defect regeneration. Pathogenetically justified stepwise application of these drugs will improve the effectiveness of treatment of post-radiation skin ulcers. This paper presents the current information about the pathogenesis of late radiation skin ulcers, the mechanism of action of SOD, epidermal growth factor preparations, as well as the importance of the microenvironment and the homing effect in controlling the links of the pathogenesis of radiation ulcers and the possibility of their reparative regeneration.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of nutritional risk factors on the development of multiple sclerosis","authors":"L. I. Gomanova, Y. A. Balanova","doi":"10.61634/2782-3024-2024-13-64-74","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-64-74","url":null,"abstract":"The literature review considers the data on the assessment of the influence of alimentary factors on the development of a severe neurological disease - multiple sclerosis (MS). MS is a polyetiologic disease, the risk of development of which is influenced by both infectious (Epstein-Barr virus, herpes simplex virus, influenza virus, etc.) and noninfectious factors (genetic predisposition, smoking, geographic region of residence, etc.). MS is a progressive demyelinating disease of the central nervous system (CNS), which leads to neurodegeneration accompanied by a variety of clinical manifestations. The pathogenesis of MS is characterized by immune-mediated damage to the myelin sheaths of nerve fibers, which is manifested by inflammation, neurosynaptic damage, and destruction of white matter, axons, and blood vessels. Rapid non-evolutionary dietary and lifestyle changes, which are driven by urbanization, industrialization and globalization of the food market, are leading to an increase in most chronic non-communicable diseases, including MS. The effects induced by alimentary factors are due to changes in the microbial composition of the gastrointestinal tract (GIT), immune cell function, enzyme systems functioning, etc. The aim of the work is to study the influence of micro/macronutrients, as well as the nature of the diet on the risk of MS development, to assess the role of nutrition in the primary prevention of MS. It has been shown that a diet characterized by a high content of animal fats and trans-isomers of fatty acids (TFA), increased consumption of meat products, but low content of vegetables, fruits and whole-grain products is associated with a higher risk of MS development. Regular inclusion in the diet of sources of polyunsaturated fatty acids (PUFAs) (vegetable oils, seeds, nuts, marine fish) and vitamin D (fatty fish, caviar, butter, egg yolk) leads to lower relapse rates and less new brain lesions among MS patients. The literature review was conducted using open sources posted in electronic databases: PubMed, Medline, Scopus, Google Scholar, World Bank publications, WHO, eLibrary, Cyberleninka, Web of Science.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of polyphenolic compounds on human health and the course of a number of diseases","authors":"N. D. Kyazimova, V. V. Kornyakova","doi":"10.61634/2782-3024-2024-13-87-91","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-87-91","url":null,"abstract":"The purpose of this literature review is to elucidate the biological effects of polyphenols and their importance for human health. Polyphenols play the role of food antioxidants and are of growing interest in various fields of scientific research and including nutritional research due to the presence of these compounds in plant foods. In this review, a brief classification of polyphenols is presented. Polyphenols include a diverse group of compounds such as phenolic acids, flavonoids, stilbenes and lignans. Flavonoids are found in fruits such as apples, apricots, grapes and citrus fruits; vegetables are rich in phenolic acids. Polyphenols are also rich in nuts, legumes, green tea, blueberries, cocoa. Polyphenols are of interest because of their effective direct and indirect antioxidant mechanisms for attenuating chronic diseases, as well as leveling negative lifestyle and nutritional factors. The antioxidant properties of polyphenolic compounds limit oxidative stress, which is relevant in geriatrics. Through a diet enriched with polyphenols, it is possible to reduce the likelihood of developing cancer, and diabetes. The favorable effect of polyphenols is noted on the functioning of the cardiovascular system. Polyphenols protect the endothelium from damage, slow the formation of atherosclerotic plaques, exhibit antithrombotic action. Having antioxidant activity, polyphenols inhibit lipoperoxidation processes, having a therapeutic effect in Alzheimer's and Parkinson's disease. In particular, catechins are effective in Parkinson's disease and ferulic acid is effective in patients with Alzheimer's disease. The protective effects of polyphenols associated with their antioxidant activity make the use of these compounds in geriatrics attractive. Due not only to their antioxidant but also hypoglycemic properties, polyphenols may be an additional treatment for diabetes mellitus. The polyphenols theaflavins and thearubigins, found in black tea and possessing antioxidant properties, have anti-cancer effects. Polyphenols also protect the skin from sun damage. It can be concluded that patients with chronic diseases should be prescribed a diet rich in polyphenols.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying professional and pedagogical deficiencies of a medical university teacher","authors":"N. A. Getman, E. N. Kotenko","doi":"10.61634/2782-3024-2024-13-92-100","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-92-100","url":null,"abstract":"In this article, the authors presented certain results of a study devoted to identifying deficiencies in the psychological and pedagogical activities of medical university teachers. A definition is given to the concept of professional deficits as a lack (limitation) in professional competence that prevents the effective implementation of professional actions. The purpose of this work was to describe the areas of professional deficits of teachers of higher medical schools. In the article, the authors tried to answer the questions: How ready are the teaching staff of a medical university for changes in the higher education system? What professional deficiencies most often arise among teachers and how to deal with them? A number of studies conducted at the Department of Pedagogy and Psychology of Further Education indicate that university teachers have a number of professional deficiencies. The reasons for these deficits are varied, since the work experience of teachers, areas of professional deficits, etc. vary. \u0000The work was based on regulatory documents, such as “Strategic priorities in the implementation of the state program of the Russian Federation “Development of Education” until 2030.” Professional deficits were examined in five main areas of professional pedagogical activity: scientific-theoretical, methodological, psychological-pedagogical, communicative and general pedagogical. Research on deficits in these areas has been conducted and analyzed. Professional deficits were identified through a sociological survey of teachers in offline and online formats using a specially created questionnaire. The questionnaire was developed using tools from various areas of psychological and pedagogical knowledge. The set of these deficits is unique for each teacher. No teacher is immune from professional difficulties: both young and experienced teachers face them. \u0000Professional pedagogical deficits depend not only on the personal characteristics and developed competencies of the teacher, but also on the developing educational environment in which he is located. Purposeful work in this direction will help to overcome professional deficits. This activity is carried out by the Department of Pedagogy and Psychology of Further Education during advanced training and professional retraining of university teachers.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of the use of chemical weapons for military purposes and the possibility of their current use","authors":"M. Y. Kozlov, I. V. Ashvits","doi":"10.61634/2782-3024-2024-13-75-86","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-75-86","url":null,"abstract":"Throughout the history of mankind there have been many wars of both local character and large-scale wars. At the heart of military actions necessarily lies the use of weapons, one type of which is chemical. Chemical weapons, the basis of which are diverse in their effect on the body and chemical composition of poisonous substances, began to be used for military purposes during World War I, namely, the first use occurred on April 22, 1915 in Belgium near the city of Ypres. Germany used gas cylinders filled with chlorine in this attack. The man who created this weapon was German chemist Fritz Haber, who became known as the \"father of chemical weapons\". Since that time, scientists from different countries began to actively study the effect of poisonous substances on the human body, synthesize their new types, as well as search for reliable means of protection against its effects. Throughout history, attempts have been made to ban the use of chemical weapons. In particular, after the end of the First World War, the Geneva Protocol was adopted in 1925, prohibiting the use of asphyxiating, poisonous or other similar gases in war. However, this agreement failed to limit the use of poisonous substances, which led to their further use, mainly in localized wars. Much work on the prohibition and destruction of chemical weapons belongs to the Organization for the Prohibition of Chemical Weapons, established in 1997 after the adoption of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction in 1993. The purpose of this paper is to summarize the history of chemical weapons for military purposes, as well as to study the activities for their prohibition. Literary data of recent years on the history of creation, use of chemical weapons and international legal agreements on their prohibition and destruction, the main types of toxic substances, means of protection against their effects are analyzed. Conclusions are made about the possibilities of chemical weapons use at present.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk meters and markers of accelerated aging","authors":"O. A. Savchenko, I. I. Novikova, O. V. Plotnikova, O. A. Savchenko","doi":"10.61634/2782-3024-2024-13-17-29","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-17-29","url":null,"abstract":"The purpose of the study is to analyze scientific research on the establishment of risk meters and markers of aging, in order to take a set of measures to prevent accelerated aging and the development of occupational diseases in the working population, including using models on laboratory animals. Material and methods: analytical, toxicological, hygienic and statistical research methods. The object of the study was the results of our own original research on the influence of environmental factors (vibration, noise, 4-component mixture of hydrocarbons) on the organisms of model animals, as well as published research material on the establishment of risk meters and markers of aging. The results and their discussion. The study determined a direct relationship between gender, age and duration of exposure to environmental factors on model organisms exposed to 90-day exposure to occupational hazards, which made it possible to establish risk meters and markers of premature aging in animals of experimental groups, compared with the control group. The results obtained experimentally will contribute to the adoption of measures to protect the health of the labor contingent. Conclusion. The leading role of timely adoption of a set of health-saving measures to prevent the development of occupational diseases in the labor contingent is determined, based on established risk meters and markers of accelerated aging using organisms of model animals.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the impact of production factors on the processes of premature aging and changes in biological age","authors":"O. A. Savchenko, I. I. Novikova, O. V. Plotnikova, O. A. Savchenko","doi":"10.61634/2782-3024-2024-13-3-16","DOIUrl":"https://doi.org/10.61634/2782-3024-2024-13-3-16","url":null,"abstract":"The purpose of the study is to assess the role of production factors in the development of premature (accelerated) aging and changes in biological age (according to a literature review), to analyze risk factors and mechanisms that trigger the processes of premature aging and changes in biological age, in order to prevent these processes – taking a set of measures to prevent occupational diseases of all categories of the population. Material and methods: In the analysis of risk assessment of premature (cellular) aging and changes in biological age under the influence of harmful production factors, methods of hygienic diagnostics and theoretical research were used: formalization, generalization, comparison, system analysis. The object of the study was the material of scientific papers on the study of the influence of harmful production factors on the processes of cellular aging and biological age. The results and their discussion. The study determined a direct relationship between the influence of production factors on the health of the labor contingent, lifestyle and functioning of the health-saving system. The conducted research will allow a deeper understanding of the processes leading to a change in biological age and the development of premature aging by analyzing the influence of factors of the production environment, socio-economic, environmental and other conditions affecting the health and life expectancy of the working contingent. Conclusion. The leading role of preventive measures in maintaining professional performance and prolonging the life of the labor contingent is determined. The study of the processes leading to the prevention of changes in biological age and the launch of mechanisms of premature aging of the working contingent will contribute to their long-term professional activity and creative longevity.","PeriodicalId":516583,"journal":{"name":"Scientific Bulletin of the Omsk State Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}