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Gum Arabic Fibers Decreased Inflammatory Markers and Disease Severity Score among Rheumatoid Arthritis Patients, Phase II Trial. 阿拉伯胶纤维降低类风湿关节炎患者的炎症标志物和疾病严重程度评分,II期试验。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-07-05 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4197537
Ebtihal Kamal, Lamis AbdelGadir Kaddam, Maha Dahawi, Montaser Osman, Mohammed Abdelraman Salih, Alnour Alagib, Amal Saeed

Background: Rheumatoid arthritis (RA) is autoimmune inflammatory disease that attacks the synovium of the joints. Both TNFa and interleukin-1 play crucial roles in the pathogenesis of RA. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Gum Arabic fermentation by colonic bacteria increases serum butyrate concentrations, so it is considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through its derivative butyrate. To the best of our knowledge, this is the first study conducted to investigate GA intake on inflammatory markers among RA patients.

Patients and methods: This is clinical trial phase II in which 40 patients were enrolled aged 18 to 70 years. Patients received 30g/day GA for 12 weeks. TNF α, ESR, and complete blood count were measured and DAS-28 was calculated before and after regular GA consumption. Study was approved by the Ethical committee of National Medicines and Poisons Board.

Results: This study showed significant decrease in level of serum TNF α (p value 0.05) [95% CI, 0.65 -16.5], ESR (p value 0.011) [95% CI, 2.6 -18.89], and number of swollen and tender joints in RA patients after 12 weeks of GA intake which reflected as significant decrease in disease severity score DAS 28 P.V:0.00 [95% CI, 1.25 -1.99]. On the other hand, GA had trivial change in blood indices.

Conclusion: Gum Arabic has favorable immune modulator effect on rheumatoid arthritis. It can be utilized in clinical practice as adjuvant therapy.

Trial registration: This trial was registered with ClinicalTrials.gov Identifier: NCT02804581 Registered at 19 June 2016, prospective registration.

背景:类风湿关节炎(RA)是攻击关节滑膜的自身免疫性炎症性疾病。tnf - fa和白细胞介素-1在RA的发病机制中都起着至关重要的作用。阿拉伯胶(GA)是塞内加尔合欢树(Acacia senegal tree)的胶状渗出物。阿拉伯胶经结肠菌发酵可提高血清丁酸盐浓度,可作为益生元制剂。阿拉伯胶(GA)通过其衍生物丁酸酯具有抗炎活性。据我们所知,这是第一个调查GA摄入对RA患者炎症标志物影响的研究。患者和方法:这是临床II期试验,其中40例患者入组,年龄在18至70岁之间。患者服用30g/天GA,持续12周。定期服用GA前后分别测定TNF α、ESR、全血细胞计数和DAS-28。研究得到了国家药品和毒物委员会伦理委员会的批准。结果:本研究显示,服用GA 12周后,RA患者血清TNF α水平(p值0.05)[95% CI, 0.65 -16.5], ESR (p值0.011)[95% CI, 2.6 -18.89],肿胀和压痛关节数量显著降低,反映为疾病严重程度评分DAS 28 P.V:0.00 [95% CI, 1.25 -1.99]显著降低。另一方面,GA对血液指标的影响较小。结论:阿拉伯胶对类风湿关节炎具有良好的免疫调节作用。它可以作为辅助治疗在临床实践中使用。试验注册:该试验已在ClinicalTrials.gov注册,注册号:NCT02804581,注册日期为2016年6月19日,前瞻性注册。
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引用次数: 48
Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine. 同型半胱氨酸可能调节类风湿关节炎的血管功能。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-07-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8498651
Mahmoud A Alomari, Omar F Khabour, Khaldoon Alawneh, Rania A Shammaa

The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Additionally, strain-gauge plethysmography was used to determine both forearm blood flow and vascular function at rest and after occlusion. Forearm occlusion blood flow (patients: 21.9 ± 6.55 versus control: 25.5 ± 6.10ml/100mL/min) was lower (p < 0.05) while occlusion vascular resistance (patients: 4.77 ± 2.08 versus controls 3.05 ± 0.96U) was greater (p < 0.01) in rheumatoid arthritis than in the controls. Level of serum homocysteine was similar (p = 0.803) in rheumatoid arthritis group and healthy group. In addition, level of serum homocysteine was correlated with resting blood flow (r = -0.41; p < 0.02) and resting vascular resistance (r = 0.31, p < 0.05) in the patients group. The study confirms altered vascular function in rheumatoid arthritis. Uniquely, the results show that homocysteine was related to resting, but not postischemia, vascular measures. These relationships indicate that homocysteine might impact the vasculature in rheumatoid arthritis.

同型半胱氨酸对心血管疾病的影响仍不明确,特别是在类风湿性关节炎患者中。在这项调查中,同型半胱氨酸与血流量和血管阻力在类风湿关节炎之间的关系进行了检查。采用ELISA法测定了31例类风湿关节炎患者和19例表面健康受试者的血清同型半胱氨酸水平。此外,应变计体积描记术用于测定静止和闭塞后前臂血流和血管功能。类风湿关节炎患者前臂闭塞血流(21.9±6.55 ml/100mL/min)低于对照组(25.5±6.10ml/100mL/min) (p < 0.05),闭塞血管阻力(4.77±2.08 ml/ min)高于对照组(3.05±0.96U) (p < 0.01)。类风湿关节炎组与健康组血清同型半胱氨酸水平相似(p = 0.803)。此外,血清同型半胱氨酸水平与静息血流量相关(r = -0.41;P < 0.02)和静息血管阻力(r = 0.31, P < 0.05)。该研究证实了类风湿关节炎患者血管功能的改变。独特的是,结果显示同型半胱氨酸与静息有关,而与缺血后血管测量无关。这些关系表明同型半胱氨酸可能影响类风湿关节炎的血管系统。
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引用次数: 4
Musculoskeletal Disorders in Patients with Diabetes Mellitus: A Cross-Sectional Study. 糖尿病患者的肌肉骨骼疾病:一项横断面研究。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-06-19 eCollection Date: 2018-01-01 DOI: 10.1155/2018/3839872
A Majjad, Y Errahali, H Toufik, J H Djossou, M A Ghassem, J Kasouati, A El Maghraoui

Introduction: A variety of musculoskeletal disorders (MS) have been associated with diabetes mellitus (DM). This study aimed at assessing the prevalence and associated factors of MS disorders in Moroccan diabetic patients.

Methods: A cross-sectional study enrolled consecutive patients with DM. We recorded demographic features of patients and characteristics of DM. MS disorders and vascular complications were assessed by clinical examinations and investigations. Associated factors of MS disorders were assessed by univariate and multivariate analyses.

Result: 376 subjects were included; 84.6% had type 2 DM. The participants' median age was 54 years [45-62]; 41% had one or more vascular complications. 34.4% had one or more MS disorders. Osteoarthritis was present in 19.4% of patients. Hand disorders were seen in 14.4%. Shoulder capsulitis was present in 12.5%. Long duration of diabetes and dyslipidemia were associated with increased prevalence of hand abnormalities (P = 0.017; P = 0.019, respectively). Age and dyslipidemia were associated with shoulder capsulitis (P = 0.019; P = 0.047, respectively). Female gender, overweight, and nephropathy were associated with increased odds of osteoarthritis (P = 0.009, P = 0.004, and P = 0.032, respectively).

Conclusion: MS disorders are frequent in this population and associated with various factors. HbA1c level does not appear to be associated with development of MS disorders.

多种肌肉骨骼疾病(MS)与糖尿病(DM)相关。本研究旨在评估摩洛哥糖尿病患者多发性硬化症的患病率及相关因素。方法:一项横断面研究纳入了连续的糖尿病患者。我们记录了患者的人口学特征和糖尿病的特征。通过临床检查和调查来评估MS疾病和血管并发症。通过单因素和多因素分析评估多发性硬化症的相关因素。结果:共纳入376例受试者;84.6%为2型糖尿病。参与者的中位年龄为54岁[45-62];41%有一种或多种血管并发症。34.4%患有一种或多种多发性硬化症。19.4%的患者存在骨关节炎。手部障碍占14.4%。12.5%的患者出现肩包膜炎。糖尿病和血脂异常持续时间长与手部异常患病率增加相关(P = 0.017;P = 0.019)。年龄和血脂异常与肩囊炎相关(P = 0.019;P = 0.047)。女性、超重和肾病与骨关节炎发病率增加相关(分别为P = 0.009、P = 0.004和P = 0.032)。结论:多发性硬化症在该人群中较为常见,且与多种因素有关。HbA1c水平似乎与多发性硬化症的发展无关。
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引用次数: 31
Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort. 瑞典女性类风湿性关节炎诊断后的长期饮食改变:来自人群队列的数据
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-06-11 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9152480
Cecilia Lourdudoss, Laurent Arnaud, Alicja Wolk, Ronald F van Vollenhoven, Daniela Di Giuseppe

Objective: To investigate long-term dietary changes after rheumatoid arthritis (RA) diagnosis in Swedish women, compared to women without RA.

Methods: This study included 21,602 women from the Swedish Mammography Cohort (SMC), who completed dietary questionnaires in 1997 and 2009. Between 1997 and 2009, 191 women were diagnosed with RA. Dietary changes after RA diagnosis were analyzed based on intake of 82 food items. Statistical analysis included linear mixed models.

Results: Women with RA, compared to women without RA, had significantly lower intake (mean servings per week) of animal products such as black pudding, egg, kidney, and liver paste (2.94±2.73 versus 2.45±1.82, p=0.010) and dairy products (35.14±20.02 versus 28.42±16.10, p=0.040) in 1997 and of cereals and grains (31.01±15.54 versus 28.00±14.98, p=0.009) in 2009. However, multivariable adjusted changes in dietary intake from 1997 to 2009 did not show any significant difference in intake. Nevertheless, women without RA increased their intake of whole wheat bread, wheat/oat bran, and rice more than women with RA.

Conclusion: Women who had been diagnosed with RA had similar dietary patterns over time as the general population; these women did not remarkably change their diet over time due to their disease. Dietary recommendations for RA patients are needed.

目的:调查瑞典女性类风湿性关节炎(RA)诊断后的长期饮食变化,与未患RA的女性相比。方法:本研究包括21602名来自瑞典乳房x线摄影队列(SMC)的女性,她们于1997年和2009年完成了饮食调查问卷。1997年至2009年间,有191名女性被诊断患有类风湿性关节炎。基于82种食物的摄入,分析RA诊断后的饮食变化。统计分析包括线性混合模型。结果:与没有RA的女性相比,患有RA的女性在1997年的黑布丁、鸡蛋、肾和肝糊等动物产品(2.94±2.73比2.45±1.82,p=0.010)和乳制品(35.14±20.02比28.42±16.10,p=0.040)和2009年的谷物和谷物(31.01±15.54比28.00±14.98,p=0.009)的摄入量(平均每周摄入量)显著降低。然而,1997年至2009年膳食摄入量的多变量调整变化并没有显示出摄入量的显著差异。然而,没有类风湿性关节炎的女性比有类风湿性关节炎的女性更多地摄入全麦面包、小麦/燕麦麸和大米。结论:被诊断为类风湿性关节炎的女性与一般人群的饮食模式相似;随着时间的推移,这些女性并没有因为疾病而显著改变饮食习惯。RA患者的饮食建议是必要的。
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引用次数: 6
Kuwait Recommendations on Vaccine Use in People with Inflammatory Rheumatic Diseases. 科威特关于炎症性风湿病患者使用疫苗的建议。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-05-13 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5217461
Ahmad AlEnizi, Khaled AlSaeid, Adel Alawadhi, Eiman Hasan, Entesar H Husain, Ahmad AlFadhli, Aqeel Ghanem, Fatemah Abutiban, Yaser Ali, Adeeba Al-Herz, Khuloud Mohammed, Waleed Alkandari, Ali Aldei, Hebah Alhajeri, Ahmad Dehrab, Sawsan Hayat

People with IRD are at increased risk of infection, and in 2011 EULAR made general recommendations for vaccination in these patients. Global and European perspectives are important, but they cannot accurately reflect the individual situations of patients in different countries and regions. Based on our clinical experience and opinions, we have sought to tailor the original EULAR recommendations to include advice for vaccination with new agents approved in the intervening years-including the new class of targeted synthetic disease-modifying antirheumatic drugs. We have also considered the specific demographic needs of patients in local populations in the Gulf region. The resulting 16 recommendations are grouped into four main categories covering general vaccination guidelines and best-practice for all patients with IRD, followed by a set of recommended vaccines against specific pathogens. The last two categories include recommendations for certain patient subgroups with defined risks and for patients who wish to travel.

IRD患者的感染风险增加,2011年EULAR提出了为这些患者接种疫苗的一般性建议。全球和欧洲的观点固然重要,但它们无法准确反映不同国家和地区患者的具体情况。根据我们的临床经验和意见,我们对 EULAR 最初的建议进行了调整,纳入了在这几年中批准的新药物(包括新型靶向合成改善病情抗风湿药物)的疫苗接种建议。我们还考虑了海湾地区当地人口中患者的特殊需求。最终提出的 16 项建议分为四大类,包括针对所有 IRD 患者的一般疫苗接种指南和最佳做法,其次是针对特定病原体的一套推荐疫苗。最后两类包括针对具有特定风险的某些患者亚群和希望旅行的患者的建议。
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引用次数: 0
Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study. 韩国成人类风湿关节炎和呼吸道变应性疾病的相关性:倾向评分匹配病例对照研究
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-04-23 eCollection Date: 2018-01-01 DOI: 10.1155/2018/3798124
Han Eol Jeong, Sung-Mok Jung, Sung-Il Cho

Rheumatoid arthritis (RA) and allergic diseases are result of a poor functioning immune system, giving dominance to either T-helper 1 (Th1) or T-helper 2 (Th2) diseases, respectively. Studies have stated that there seems to be a relationship present between the immune response subsets. This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. The study utilized the KNHANES 2013-2015 data and excluded individuals diagnosed with RA before being diagnosed with allergic diseases, using age at clinical diagnosis. Total of 253 RA patients were matched 1 : 1 with non-RA patients by a propensity score, using sex and age as matched variables. Multivariate conditional logistic regression analyses were used to evaluate for association between RA and respiratory allergic diseases in the matched 506 participants. RA was associated with an increased risk of prevalence of respiratory allergic diseases with an OR of 1.51 (95% CI, 1.31-1.75), adjusted for socioeconomic demographic variables. The adjusted OR for prevalence of RA among participants with prevalence of asthma and allergic rhinitis was as follows: 3.12 (95% CI, 2.77-3.51) and 1.39 (95% CI, 1.16-1.67). Participants with prevalence of asthma in particular had an increased risk of developing prevalence of RA. Based on our findings, Th1 and Th2 diseases may indeed coexist, and one pathway may stimulate or contribute towards the onset of the other.

类风湿关节炎(RA)和过敏性疾病是免疫系统功能低下的结果,分别由t -辅助性1 (Th1)或t -辅助性2 (Th2)疾病主导。研究表明,免疫反应亚群之间似乎存在某种关系。本研究旨在探讨韩国成人风湿性关节炎与呼吸道变态反应性疾病之间的关系。该研究使用了KNHANES 2013-2015数据,并排除了在诊断为过敏性疾病之前诊断为RA的个体,使用临床诊断时的年龄。共有253例RA患者与非RA患者以性别和年龄作为匹配变量,通过倾向评分进行1:1匹配。使用多变量条件logistic回归分析评估匹配的506名参与者中RA与呼吸道变态反应性疾病的相关性。经社会经济人口统计变量调整后,RA与呼吸道过敏性疾病患病率增加相关,OR为1.51 (95% CI, 1.31-1.75)。哮喘和变应性鼻炎患者中RA患病率的调整OR如下:3.12 (95% CI, 2.77-3.51)和1.39 (95% CI, 1.16-1.67)。患有哮喘的参与者患类风湿关节炎的风险增加。根据我们的发现,Th1和Th2疾病可能确实共存,其中一条途径可能刺激或促成另一条途径的发病。
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引用次数: 15
AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis. AC-CUTE:一项评估中度至重度类风湿关节炎患者结构性关节损伤和炎症进展的开放标签研究。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-04-12 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8721753
Paul Bird, Charles Peterfy, Peter Countryman, Hedley Griffiths, Rina Barrett, Peter Youssef, Fredrick Joshua, Stephen Hall

Aim: Examine the efficacy of once-weekly subcutaneous tocilizumab (SC-TCZ) on joint damage at 24 weeks based on radiography of the hands and feet and magnetic resonance imaging (MRI) of the hand in subjects with moderate to severe rheumatoid arthritis (RA).

Methods: In this Australian open-label, multicentre, prospective, single-arm study, subjects received 162 mg SC-TCZ weekly. Primary endpoint was change in radiographic Genant-modified Total Sharp Score (TSS) between baseline and Week 24. Secondary endpoints included change from baseline to Week 24 in RA MRI scoring (RAMRIS) of erosions, synovitis, and osteitis and Cartilage Loss Score (CARLOS) in the dominant hand and disease activity score 28 (DAS28).

Results: 52 subjects were enrolled (80% female, mean (SD) age 57  (12) years). Radiography showed mild but not significant progression of joint damage (mean (SD) change in TSS 0.46 (1.29)). Synovitis reduced significantly on MRI; however, osteitis, erosion, and cartilage loss did not change significantly. DAS28 improved significantly by Week 24; 78% of subjects achieved DAS28 remission. SC-TCZ was generally well tolerated.

Conclusion: Synovitis and DAS28 decreased significantly; however, no significant change in osteitis or joint damage was observed at Week 24.

Trial registration: This trial is registered with Clinicaltrials.gov registration number NCT01951170 (ML28703).

目的:通过对中度至重度类风湿性关节炎(RA)患者的手脚x线片和手部磁共振成像(MRI),研究每周一次皮下tocilizumab (SC-TCZ)治疗24周关节损伤的疗效。方法:在这项澳大利亚开放标签、多中心、前瞻性单臂研究中,受试者每周接受162mg SC-TCZ。主要终点是放射学Genant-modified Total Sharp Score (TSS)在基线和第24周之间的变化。次要终点包括从基线到第24周RAMRI评分(RAMRIS)的变化,主要手的侵蚀,滑膜炎和骨炎,软骨损失评分(CARLOS)和疾病活动评分28 (DAS28)。结果:纳入52例受试者(80%为女性,平均(SD)年龄57(12)岁)。x线摄影显示关节损伤进展轻微但不明显(TSS平均(SD)变化0.46(1.29))。MRI上滑膜炎明显减轻;然而,骨炎、糜烂和软骨丢失没有明显变化。DAS28在第24周显著改善;78%的受试者达到DAS28缓解。SC-TCZ总体耐受良好。结论:滑膜炎、DAS28明显降低;然而,在第24周没有观察到骨炎或关节损伤的显著变化。试验注册:本试验在Clinicaltrials.gov注册,注册号为NCT01951170 (ML28703)。
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引用次数: 5
Oral Manifestations of Systemic Lupus Erythematosus Patients in Qatar: A Pilot Study. 卡塔尔系统性红斑狼疮患者的口腔表现:一项初步研究。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-04-10 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6052326
Mohammed Hammoudeh, Ahmed Al-Momani, Husam Sarakbi, Prem Chandra, Samer Hammoudeh

Objective: The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus (SLE) patients in Qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny.

Methods: Study procedures took place between November 2014 and April 2016. All patients visiting the outpatient rheumatology clinics at Hamad General Hospital, Doha, Qatar, were asked to join. The American College of Rheumatology (ACR) 1997 criteria of SLE were used. The patients were examined initially by a rheumatologist and were later scheduled for an appointment with a dentist at the same institution. A total of 77 patients were recruited for the study.

Results: Prevalence rates for the different oral manifestations ranged from 2.4% for soft palate ulcers, cheilitis, and oral candida to 88.1% for the presence of cavitation. Gingivitis, periodontal disease, cavities, and missing teeth were observed in more than 50% of the sample. The prevalence of periodontal disease and missing teeth was higher among those with an SLE duration > 8 years. On the contrary, the prevalence of gingivitis and cavities was higher among those with an SLE duration ≤ 8 years.

Conclusion: This study found high rates of gingivitis, periodontal disease, cavities, and missing teeth among SLE patients in Qatar. It is recommended that healthcare providers of such patients monitor the presence of any oral manifestations in order to arrange for early treatment and prevention efforts. Future prospective longitudinal studies with adequate sample size and power are needed in order to ascertain any causation factors or common etiology pathways.

目的:本初步研究的目的是评估卡塔尔系统性红斑狼疮(SLE)患者口腔表现的患病率,以保证未来的研究将详细调查每一个这些表现和进一步的审查。方法:研究程序于2014年11月至2016年4月进行。所有在卡塔尔多哈哈马德总医院风湿病门诊就诊的患者都被要求加入研究。采用美国风湿病学会(ACR) 1997年SLE诊断标准。患者最初由风湿病学家进行检查,随后与同一机构的牙医预约。这项研究共招募了77名患者。结果:不同口腔表现的患病率从软腭溃疡、口唇炎和口腔念珠菌的2.4%到存在空化的88.1%不等。在超过50%的样本中观察到牙龈炎、牙周病、蛀牙和缺牙。牙周病和缺牙的患病率在SLE病程> 8年的人群中较高。相反,在SLE病程≤8年的患者中,牙龈炎和蛀牙的患病率更高。结论:本研究发现卡塔尔SLE患者牙龈炎、牙周病、蛀牙和缺牙的发生率很高。建议此类患者的医疗保健提供者监测任何口腔表现的存在,以便安排早期治疗和预防工作。未来的前瞻性纵向研究需要足够的样本量和功率,以确定任何病因或常见的病因途径。
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引用次数: 19
Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis. 评价年轻强直性脊柱炎患者心血管风险的相对风险图评分。
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2018-02-15 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1847894
Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata Arnaiz, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez, Miguel A González-Gay

Objective: To determine if the use of the relative risk (RR) chart score may help to identify young ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease.

Methods: 73 AS patients younger than 50 years were assessed. CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) and the RR chart score. C-reactive protein (CRP) value at disease diagnosis and carotid ultrasound data were also analyzed.

Results: Twenty (27.4%) patients exhibited carotid plaques being classified into the category of very high CV risk. None of them was found to have a high/very high TC-SCORE. CRP > 3 mg/L at disease diagnosis was associated with the presence of carotid plaques (odds ratio 5.66, p = 0.03). Whereas only 5 (14.2%) of the 35 patients with RR = 1 had carotid plaques, 15 (39.5%) of 38 with RR > 1 showed plaques. A model that included the performance of carotid US in patients with RR > 1 who had CRP > 3 mg/L allowed us to identify 60% of very high risk patients, with a specificity of 77.4%.

Conclusions: RR chart score assessment may help to identify young AS patients at high risk of CV disease.

目的:确定相对危险度(RR)量表评分是否有助于识别具有心血管(CV)疾病高风险的年轻强直性脊柱炎(AS)患者。方法:对73例年龄小于50岁的AS患者进行评估。根据总胆固醇系统冠状动脉风险评价(TC-SCORE)和RR图评分计算CV风险。分析c反应蛋白(CRP)在疾病诊断中的价值及颈动脉超声资料。结果:20例(27.4%)患者的颈动脉斑块被归类为非常高心血管风险。没有发现他们有高/非常高的TC-SCORE。疾病诊断时CRP > 3 mg/L与颈动脉斑块的存在相关(优势比5.66,p = 0.03)。RR = 1的35例患者中只有5例(14.2%)出现颈动脉斑块,而RR > 1的38例患者中有15例(39.5%)出现斑块。一个包括RR > 1且CRP > 3 mg/L的患者颈动脉US表现的模型使我们能够识别60%的高危患者,特异性为77.4%。结论:RR表评分评估有助于识别心血管疾病高风险的年轻AS患者。
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引用次数: 4
Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases 分离的Ro52抗体作为一种轻度表型的未分化结缔组织疾病的免疫标记
IF 2.3 Q2 RHEUMATOLOGY Pub Date : 2017-01-22 DOI: 10.1155/2017/3076017
A. Alonso-Larruga, S. Bustabad, J. A. Navarro-Gonzálvez, B. Rodríguez-Lozano, A. Franco, Y. Barrios
The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time.
术语未分化结缔组织病(UCTD)用于描述未确诊的患者,这些患者不符合明确结缔组织病的分类标准(系统性狼疮、系统性硬化症、干燥综合征和皮肌炎/多发性肌炎)。重要的是要找到血清学标志物作为这些疾病进化或严重程度的预测因素。这项回顾性研究的目的是调查是否有一个较轻的UCTD亚组具有特殊的临床特征,仅在存在抗Ro52自身抗体的情况下。研究了62名住院患者在30个月内的免疫学和临床记录。结果显示,目标人群主要由女性组成,研究时年龄在40至80岁之间,登记发病年龄在40岁至60岁之间。斑点模式是间接免疫荧光发现的最常见的模式。鉴于所获得的结果,并考虑到样本量可能带来的限制,分离的阳性抗Ro52自身抗体似乎会对疾病的发展产生良性影响。作为未来的目标,有必要对这些患者进行随访,以研究新的临床症状、血清学标志物或随着时间的推移确定的结缔组织疾病的发展。
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引用次数: 6
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International Journal of Rheumatology
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