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Ad Hoc Modifications to a High Dependency Psychiatric Unit for People With Dementia During the COVID-19 Period. 在 COVID-19 期间,对痴呆症患者高依赖性精神病科进行临时改建。
IF 1.9 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-06-11 DOI: 10.2196/49618
Thanita Pilunthanakul, Giles Ming Yee Tan

The COVID-19 pandemic led to behavioral exacerbations in people with dementia. Increased hospitalizations and lack of bed availability in specialized dementia wards at a tertiary psychiatric hospital in Singapore resulted in lodging people with dementia in the High Dependency Psychiatric Unit (HDPCU). Customizations to create a dementia-friendly environment at the HDPCU included: (1) environmental modifications to facilitate orientation and engender familiarity; (2) person-centered care to promote attachment, inclusion, identity, occupation, and comfort; (3) risk management for delirium; and (4) training core competencies. Such practical solutions can also be implemented elsewhere to help overcome resource constraints and repurpose services to accommodate increasing populations of people living with dementia.

COVID-19 大流行导致痴呆症患者的行为加剧。新加坡一家三级精神病医院的住院人数增加,但痴呆症专科病房床位不足,因此痴呆症患者被安置在高危精神病病房(HDPCU)。为在高危精神病房创造一个对痴呆症患者友好的环境而进行的定制工作包括(1)环境改造,以方便定位和建立熟悉感;(2)以人为本的护理,以促进依恋、包容、身份认同、职业和舒适感;(3)谵妄风险管理;以及(4)培训核心能力。这些切实可行的解决方案也可以在其他地方实施,以帮助克服资源限制并重新调整服务用途,以适应日益增多的痴呆症患者。
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引用次数: 0
Visual "Scrollytelling": Mapping Aquatic Selfie-Related Incidents in Australia. 视觉 "自拍":绘制澳大利亚水上自拍相关事件图。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-05-23 DOI: 10.2196/53067
Samuel Cornell, Amy E Peden
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引用次数: 0
Theoretical Perspectives Underpinning Research on the Physician-Patient Relationship in a Digital Health Practice: Scoping Review. 数字医疗实践中医患关系研究的理论基础:范围审查。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-05-15 DOI: 10.2196/47280
Damoun Nassehi, Birgitta Haga Gripsrud, Ellen Ramvi
<p><strong>Background: </strong>The advent of digital health technologies has transformed the landscape of health care, influencing the dynamics of the physician-patient relationship. Although these technologies offer potential benefits, they also introduce challenges and complexities that require ethical consideration.</p><p><strong>Objective: </strong>This scoping review aims to investigate the effects of digital health technologies, such as digital messaging, telemedicine, and electronic health records, on the physician-patient relationship. To understand the complex consequences of these tools within health care, it contrasts the findings of studies that use various theoretical frameworks and concepts with studies grounded in relational ethics.</p><p><strong>Methods: </strong>Using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines, we conducted a scoping review. Data were retrieved through keyword searches on MEDLINE/PubMed, Embase, IEEE Xplore, and Cochrane. We screened 427 original peer-reviewed research papers published in English-language journals between 2010 and 2021. A total of 73 papers were assessed for eligibility, and 10 of these were included in the review. The data were summarized through a narrative synthesis of the findings.</p><p><strong>Results: </strong>Digital health technologies enhance communication, improve health care delivery efficiency, and empower patients, leading to shifts in power dynamics in the physician-patient relationship. They also potentially reinforce inequities in health care access due to variations in technology literacy among patients and lead to decreases in patient satisfaction due to the impersonal nature of digital interactions. Studies applying a relational ethics framework have revealed the nuanced impacts of digital health technologies on the physician-patient relationship, highlighting shifts toward more collaborative and reciprocal care. These studies have also explored transitions from traditional hierarchical relationships to mutual engagement, capturing the complexities of power dynamics and vulnerabilities. Other theoretical frameworks, such as patient-centered care, and concepts, such as patient empowerment, were also valuable for understanding these interactions in the context of digital health.</p><p><strong>Conclusions: </strong>The shift from hierarchical to collaborative models in the physician-patient relationship not only underscores the empowering potential of digital tools but also presents new challenges and reinforces existing ones. Along with applications for various theoretical frameworks and concepts, this review highlights the unique comprehensiveness of a relational ethics perspective, which could provide a more nuanced understanding of trust, empathy, and power dynamics in the context of digital health. The adoption of relational ethics in empirical research may offer richer insights into the real-
背景:数字医疗技术的出现改变了医疗保健的格局,影响了医患关系的动态发展。尽管这些技术具有潜在的益处,但它们也带来了挑战和复杂性,需要从伦理角度加以考虑:本范围综述旨在调查数字医疗技术(如数字信息、远程医疗和电子健康记录)对医患关系的影响。为了解这些工具在医疗保健领域的复杂影响,本综述将使用各种理论框架和概念的研究结果与基于关系伦理的研究结果进行对比:我们采用 PRISMA-ScR(系统综述和荟萃分析的首选报告项目,范围界定综述的扩展)指南进行了范围界定综述。我们通过在 MEDLINE/PubMed、Embase、IEEE Xplore 和 Cochrane 上进行关键词检索来获取数据。我们筛选了 2010 年至 2021 年间在英文期刊上发表的 427 篇经同行评审的原创研究论文。共有 73 篇论文通过了资格评估,其中 10 篇被纳入综述。通过对研究结果进行叙述性综合,对数据进行了总结:数字医疗技术加强了沟通,提高了医疗服务效率,增强了患者的能力,从而改变了医患关系中的权力动态。同时,由于患者技术素养的差异,数字医疗技术还可能加剧医疗服务的不平等,并由于数字互动的非个人化性质,导致患者满意度下降。应用关系伦理学框架的研究揭示了数字医疗技术对医患关系的细微影响,强调了向更具协作性和互惠性医疗的转变。这些研究还探讨了从传统的等级关系到相互参与的转变,捕捉到了权力动态和脆弱性的复杂性。以患者为中心的护理等其他理论框架和患者赋权等概念对于理解数字医疗背景下的这些互动也很有价值:医患关系从等级模式到协作模式的转变不仅强调了数字工具的赋权潜力,也提出了新的挑战并强化了现有的挑战。除了各种理论框架和概念的应用之外,本综述还强调了关系伦理学视角的独特全面性,它可以为数字医疗背景下的信任、移情和权力动态提供更细致入微的理解。在实证研究中采用关系伦理学视角,可以让人们更深入地了解以数字技术为媒介的医患关系在现实生活中的复杂性。
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引用次数: 0
Predicting the Effectiveness of a Mindfulness Virtual Community Intervention for University Students: Machine Learning Model. 预测大学生正念虚拟社区干预措施的效果:机器学习模型
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-05-13 DOI: 10.2196/50982
Christo El Morr, Farideh Tavangar, Farah Ahmad, Paul Ritvo

Background: Students' mental health crisis was recognized before the COVID-19 pandemic. Mindfulness virtual community (MVC), an 8-week web-based mindfulness and cognitive behavioral therapy program, has proven to be an effective web-based program to reduce symptoms of depression, anxiety, and stress. Predicting the success of MVC before a student enrolls in the program is essential to advise students accordingly.

Objective: The objectives of this study were to investigate (1) whether we can predict MVC's effectiveness using sociodemographic and self-reported features and (2) whether exposure to mindfulness videos is highly predictive of the intervention's success.

Methods: Machine learning models were developed to predict MVC's effectiveness, defined as success in reducing symptoms of depression, anxiety, and stress as measured using the Patient Health Questionnaire-9 (PHQ-9), the Beck Anxiety Inventory (BAI), and the Perceived Stress Scale (PSS), to at least the minimal clinically important difference. A data set representing a sample of undergraduate students (N=209) who took the MVC intervention between fall 2017 and fall 2018 was used for this secondary analysis. Random forest was used to measure the features' importance.

Results: Gradient boosting achieved the best performance both in terms of area under the curve (AUC) and accuracy for predicting PHQ-9 (AUC=0.85 and accuracy=0.83) and PSS (AUC=1 and accuracy=1), and random forest had the best performance for predicting BAI (AUC=0.93 and accuracy=0.93). Exposure to online mindfulness videos was the most important predictor for the intervention's effectiveness for PHQ-9, BAI, and PSS, followed by the number of working hours per week.

Conclusions: The performance of the models to predict MVC intervention effectiveness for depression, anxiety, and stress is high. These models might be helpful for professionals to advise students early enough on taking the intervention or choosing other alternatives. The students' exposure to online mindfulness videos is the most important predictor for the effectiveness of the MVC intervention.

Trial registration: ISRCTN Registry ISRCTN12249616; https://www.isrctn.com/ISRCTN12249616.

背景:在 COVID-19 大流行之前,人们就已经意识到学生的心理健康危机。正念虚拟社区(MVC)是一个为期八周的网络正念和认知行为疗法(CBT)项目,已被证明是一个有效的网络项目,可减轻抑郁、焦虑和压力症状。在学生报名参加该项目之前预测 MVC 的成功率对于向学生提供相应建议至关重要:本研究的目的是调查:(1)我们是否能利用社会人口学和自我报告特征预测 MVC 的有效性;(2)接触正念视频是否能高度预测干预的成功:我们开发了机器学习模型来预测 MVC 的有效性,MVC 的定义是成功减少抑郁、焦虑和压力症状,这些症状是使用患者健康问卷-9(PHQ9)、贝克焦虑量表(BAI)和感知压力量表(PSS)测量的,至少达到最小临床重要差异(MCID)。本次二次分析使用的数据集代表了在 2017 年秋季至 2018 年秋季期间参加 MVC 干预的本科生样本(n = 209)。随机森林用于衡量特征的重要性:梯度提升法在预测PHQ 9(AUC=.85,准确率=.83)和PSS(AUC=1,准确率=1)方面的AUC和准确率都达到了最佳性能;而随机森林在预测BAI方面的性能最佳(AUC=.93,准确率=.93)。在PHQ9、BAI和PSS方面,接触在线正念视频是干预效果的最重要预测因素,其次是每周工作小时数:预测 MVC 对抑郁、焦虑和压力的干预效果的模型具有很高的性能。这些模型可能有助于专业人士及早建议学生接受干预或选择其他方法。学生接触在线正念视频是预测MVC干预效果的最重要因素:ISRCTN Registry ISRCTN12249616; http://www.isrctn.com/ISRCTN12249616.
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引用次数: 0
Using Routine Data to Improve Lesbian, Gay, Bisexual, and Transgender Health. 利用常规数据改善女同性恋、男同性恋、双性恋和变性者的健康。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-05-01 DOI: 10.2196/53311
Catherine L Saunders

The collection of sexual orientation in routine data, generated either from contacts with health services or in infrastructure data resources designed and collected for policy and research, has improved substantially in the United Kingdom in the last decade. Inclusive measures of gender and transgender status are now also beginning to be collected. This viewpoint considers current data collections, and their strengths and limitations, including accessing data, sample size, measures of sexual orientation and gender, measures of health outcomes, and longitudinal follow-up. The available data are considered within both sociopolitical and biomedical models of health for individuals who are lesbian, gay, bisexual, transgender, queer, or of other identities including nonbinary (LGBTQ+). Although most individual data sets have some methodological limitations, when put together, there is now a real depth of routine data for LGBTQ+ health research. This paper aims to provide a framework for how these data can be used to improve health and health care outcomes. Four practical analysis approaches are introduced-descriptive epidemiology, risk prediction, intervention development, and impact evaluation-and are discussed as frameworks for translating data into research with the potential to improve health.

在过去十年中,联合王国在常规数据中收集性取向数据的工作有了很大改进,这些数据或来自与医疗服务机构的联系,或来自为政策和研究而设计和收集的基础设施数据资源。现在也开始收集有关性别和变性状况的包容性测量数据。这一观点考虑了当前的数据收集及其优势和局限性,包括数据获取、样本大小、性取向和性别测量、健康结果测量以及纵向跟踪。现有数据是在社会政治和生物医学模式下,针对女同性恋、男同性恋、双性恋、变性人、同性恋者或其他身份包括非二元身份(LGBTQ+)的个人健康状况进行考虑的。尽管大多数单个数据集在方法上存在一定的局限性,但如果将这些数据集放在一起,就能为 LGBTQ+ 健康研究提供真正有深度的常规数据。本文旨在为如何利用这些数据来改善健康和医疗保健成果提供一个框架。本文介绍了四种实用的分析方法--描述性流行病学、风险预测、干预发展和影响评估,并将其作为将数据转化为有可能改善健康状况的研究的框架进行讨论。
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引用次数: 0
Gamification and Oral Health in Children and Adolescents: Scoping Review. 游戏化与儿童和青少年口腔健康:范围审查。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-04 DOI: 10.2196/35132
Rui Moreira, Augusta Silveira, Teresa Sequeira, Nuno Durão, Jessica Lourenço, Inês Cascais, Rita Maria Cabral, Tiago Taveira Gomes
<p><strong>Background: </strong>Oral health is a determinant of overall well-being and quality of life. Individual behaviors, such as oral hygiene and dietary habits, play a central role in oral health. Motivation is a crucial factor in promoting behavior change, and gamification offers a means to boost health-related knowledge and encourage positive health behaviors.</p><p><strong>Objective: </strong>This study aims to evaluate the impact of gamification and its mechanisms on oral health care of children and adolescents.</p><p><strong>Methods: </strong>A systematic search covered multiple databases: PubMed/MEDLINE, PsycINFO, the Cochrane Library, ScienceDirect, and LILACS. Gray literature, conference proceedings, and WHOQOL internet resources were considered. Studies from January 2013 to December 2022 were included, except for PubMed/MEDLINE, which was searched until January 2023. A total of 15 studies were selected following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The eligibility criteria were peer-reviewed, full-text, and empirical research related to gamification in oral health care, reports of impact, and oral health care outcomes. The exclusion criteria encompassed duplicate articles; unavailable full texts; nonoriginal articles; and non-digital game-related, non-oral health-related, and protocol studies. Selected studies were scrutinized for gamification mechanisms and outcomes. Two main questions were raised: "Does gamification in oral health care impact oral health?" and "Does oral health care gamification enhance health promotion and literacy?" The PICO (Patient, Intervention, Comparison, Outcome) framework guided the scoping review.</p><p><strong>Results: </strong>Initially, 617 records were obtained from 5 databases and gray literature sources. After applying exclusion criteria, 15 records were selected. Sample size in the selected studies ranged from 34 to 190 children and adolescents. A substantial portion (11/15, 73%) of the studies discussed oral self-care apps supported by evidence-based oral health. The most clearly defined data in the apps were "brushing time" (11/11, 100%) and "daily amount brushing" (10/11, 91%). Most studies (11/15, 73%) mentioned oral health care behavior change techniques and included "prompt intention formation" (11/26, 42%), "providing instructions" (11/26, 42%), "providing information on the behavior-health link" (10/26, 38%), "providing information on consequences" (9/26, 35%), "modeling or demonstrating behavior" (9/26, 35%), "providing feedback on performance" (8/26, 31%), and "providing contingent rewards" (8/26, 31%). Furthermore, 80% (12/15) of the studies identified game design elements incorporating gamification features in oral hygiene applications. The most prevalent gamification features were "ideological incentives" (10/12, 83%) and "goals" (9/16, 56%), which were found in user-specific and challenge categories, respectively.</p><p><strong>Conc
背景:口腔健康是整体福祉和生活质量的决定因素。口腔卫生和饮食习惯等个人行为对口腔健康起着核心作用。动机是促进行为改变的关键因素,而游戏化提供了一种提高健康相关知识和鼓励积极健康行为的手段:本研究旨在评估游戏化及其机制对儿童和青少年口腔保健的影响:方法:对多个数据库进行系统检索:PubMed/MEDLINE、PsycINFO、Cochrane 图书馆、ScienceDirect 和 LILACS。还考虑了灰色文献、会议论文集和 WHOQOL 互联网资源。除PubMed/MEDLINE(搜索至2023年1月)外,2013年1月至2022年12月的研究均被纳入。根据 PRISMA(系统综述和元分析首选报告项目)指南,共筛选出 15 项研究。合格标准为经同行评审的全文,以及与口腔保健游戏化、影响报告和口腔保健结果相关的实证研究。排除标准包括重复文章、无法获得的全文、非原创文章、非数字游戏相关、非口腔健康相关和协议研究。对所选研究的游戏化机制和结果进行了仔细研究。提出了两个主要问题:"口腔保健游戏化对口腔健康有影响吗?"和 "口腔保健游戏化是否能提高健康促进和素养?PICO(患者、干预、比较、结果)框架为范围界定审查提供了指导:最初从 5 个数据库和灰色文献来源获得了 617 条记录。在采用排除标准后,选出了 15 条记录。所选研究的样本量从 34 到 190 名儿童和青少年不等。大部分研究(11/15,73%)讨论了口腔自我护理应用程序,这些应用程序得到了以证据为基础的口腔健康的支持。应用程序中最明确的数据是 "刷牙时间"(11/11,100%)和 "每日刷牙量"(10/11,91%)。大多数研究(11/15,73%)提到了口腔保健行为改变技术,包括 "促使意向形成"(11/26,42%)、"提供指导"(11/26,42%)、"提供行为与健康联系的信息"(10/26,38%)、"提供后果信息"(9/26,35%)、"示范或演示行为"(9/26,35%)、"提供表现反馈"(8/26,31%)和 "提供或有奖励"(8/26,31%)。此外,80%(12/15)的研究确定了在口腔卫生应用中融入游戏化特征的游戏设计元素。最普遍的游戏化特征是 "意识形态激励"(10/12,83%)和 "目标"(9/16,56%),它们分别出现在特定用户和挑战类别中:口腔保健中的游戏化作为一种促进积极健康行为的创新方法,显示了其潜力。大多数研究报告了基于证据的口腔保健,并纳入了口腔保健行为改变技术。
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引用次数: 0
Evaluation of an mHealth App on Self-Management of Osteoporosis: Prospective Survey Study. 骨质疏松症自我管理移动医疗应用程序的评估:前瞻性调查研究。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-01 DOI: 10.2196/53995
Magnus Grønlund Bendtsen, Bodil Marie Thuesen Schönwandt, Mette Rubæk, Mette Friberg Hitz

Background: Mobile health (mHealth) technologies can be used for disease-specific self-management, and these technologies are experiencing rapid growth in the health care industry. They use mobile devices, specifically smartphone apps, to enhance and support medical and public health practices. In chronic disease management, the use of apps in the realm of mHealth holds the potential to improve health outcomes. This is also true for mHealth apps on osteoporosis, but the usage and patients' experiences with these apps are underexplored.

Objective: This prospective survey study aimed to investigate the eHealth literacy of Danish patients with osteoporosis, as well as the usability and acceptability of the app "My Bones."

Methods: Data on patient characteristics, disease knowledge, eHealth literacy, usability, and acceptability were collected using self-administered questionnaires at baseline, 2 months, and 6 months. The following validated questionnaires were used: eHealth Literacy Questionnaire, System Usability Scale, and Service User Technology Acceptability Questionnaire.

Results: Mean scores for eHealth literacy ranged from 2.6 to 3.1, with SD ranging from 0.5 to 0.6 across the 7 domains. The mean (SD) System Usability Scale score was 74.7 (14.4), and the mean (SD) scores for domains 1, 2, and 6 of the Service User Technology Acceptability Questionnaire were 3.4 (1.2), 4.5 (1.1), 4.1 (1.2), respectively.

Conclusions: Danish patients with osteoporosis are both motivated and capable of using digital health services. The app's usability was acceptable, and it has the potential to reduce visits to general practitioner clinics, enhance health outcomes, and serve as a valuable addition to regular health or social care services.

背景:移动医疗(mHealth)技术可用于特定疾病的自我管理,这些技术在医疗保健行业正经历着快速增长。它们使用移动设备,特别是智能手机应用程序,来加强和支持医疗和公共卫生实践。在慢性病管理方面,移动医疗领域的应用程序具有改善健康结果的潜力。骨质疏松症方面的移动医疗应用程序也是如此,但这些应用程序的使用情况和患者的使用体验还未得到充分探索:这项前瞻性调查研究旨在调查丹麦骨质疏松症患者的电子健康知识,以及应用程序 "我的骨骼 "的可用性和可接受性:在基线、2 个月和 6 个月时,使用自制问卷收集有关患者特征、疾病知识、电子健康知识、可用性和可接受性的数据。使用的有效问卷包括:电子健康知识问卷、系统可用性量表和服务用户技术可接受性问卷:在 7 个领域中,电子健康素养的平均得分介于 2.6 和 3.1 之间,标差介于 0.5 和 0.6 之间。系统可用性量表的平均分(标清)为 74.7 (14.4),服务用户技术可接受性问卷领域 1、2 和 6 的平均分(标清)分别为 3.4 (1.2)、4.5 (1.1)、4.1 (1.2):丹麦骨质疏松症患者有使用数字医疗服务的动机和能力。该应用程序的可用性是可以接受的,它有可能减少普通医生诊所的就诊次数,提高健康效果,并成为常规医疗或社会护理服务的重要补充。
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引用次数: 0
Designing mHealth Apps to Incorporate Evidence-Based Techniques for Prolonging User Engagement. 移动医疗应用程序设计:结合基于证据的技术,延长用户参与时间。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-26 DOI: 10.2196/51974
Rebecca Monachelli, Sharon Watkins Davis, Allison Barnard, Michelle Longmire, John P Docherty, Ingrid Oakley-Girvan

Maintaining user engagement with mobile health (mHealth) apps can be a challenge. Previously, we developed a conceptual model to optimize patient engagement in mHealth apps by incorporating multiple evidence-based methods, including increasing health literacy, enhancing technical competence, and improving feelings about participation in clinical trials. This viewpoint aims to report on a series of exploratory mini-experiments demonstrating the feasibility of testing our previously published engagement conceptual model. We collected data from 6 participants using an app that showed a series of educational videos and obtained additional data via questionnaires to illustrate and pilot the approach. The videos addressed 3 elements shown to relate to engagement in health care app use: increasing health literacy, enhancing technical competence, and improving positive feelings about participation in clinical trials. We measured changes in participants' knowledge and feelings, collected feedback on the videos and content, made revisions based on this feedback, and conducted participant reassessments. The findings support the feasibility of an iterative approach to creating and refining engagement enhancements in mHealth apps. Systematically identifying the key evidence-based elements intended to be included in an app's design and then systematically testing the implantation of each element separately until a satisfactory level of positive impact is achieved is feasible and should be incorporated into standard app design. While mHealth apps have shown promise, participants are more likely to drop out than to be retained. This viewpoint highlights the potential for mHealth researchers to test and refine mHealth apps using approaches to better engage users.

非结构化:保持用户对移动医疗(mHealth)应用的参与度是一项挑战。在此之前,我们开发了一个概念模型,通过结合多种循证方法(包括提高健康素养、增强技术能力和改善参与临床试验的感受)来优化患者对移动医疗应用程序的参与度。本观点旨在报告一系列探索性小型实验,以证明测试我们之前发布的参与概念模型的可行性。我们使用一款播放了一系列教育视频的应用程序收集了六名参与者的数据,并通过问卷调查获得了更多数据,以说明和试用该方法。这些视频涉及与参与医疗保健应用程序使用相关的三个要素:增加健康知识、提高技术能力和改善参与临床试验的积极情绪。我们测量了参与者在知识和情感方面的变化,收集了对视频和内容的反馈意见,根据这些反馈意见进行了修改,并对参与者进行了重新评估。研究结果表明,在移动医疗应用程序中采用迭代方法来创建和完善参与度增强功能是可行的。系统性地确定应用程序设计中应包含的关键循证要素,然后分别对每个要素的植入进行系统性测试,直到达到令人满意的积极影响水平,这种方法是可行的,应纳入标准应用程序设计中。虽然移动医疗应用程序已显示出良好的前景,但参与者退出的可能性要大于保留的可能性。这一观点凸显了移动医疗研究人员使用更好地吸引用户的方法测试和改进移动医疗应用程序的潜力。
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引用次数: 0
Influence of Environmental Factors and Genome Diversity on Cumulative COVID-19 Cases in the Highland Region of China: Comparative Correlational Study. 环境因素和基因组多样性对中国高原地区 COVID-19 累计病例的影响:比较相关性研究。
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-25 DOI: 10.2196/43585
Zhuoga Deji, Yuantao Tong, Honglian Huang, Zeyu Zhang, Meng Fang, M James C Crabbe, Xiaoyan Zhang, Ying Wang
<p><strong>Background: </strong>The novel coronavirus SARS-CoV-2 caused the global COVID-19 pandemic. Emerging reports support lower mortality and reduced case numbers in highland areas; however, comparative studies on the cumulative impact of environmental factors and viral genetic diversity on COVID-19 infection rates have not been performed to date.</p><p><strong>Objective: </strong>The aims of this study were to determine the difference in COVID-19 infection rates between high and low altitudes, and to explore whether the difference in the pandemic trend in the high-altitude region of China compared to that of the lowlands is influenced by environmental factors, population density, and biological mechanisms.</p><p><strong>Methods: </strong>We examined the correlation between population density and COVID-19 cases through linear regression. A zero-shot model was applied to identify possible factors correlated to COVID-19 infection. We further analyzed the correlation of meteorological and air quality factors with infection cases using the Spearman correlation coefficient. Mixed-effects multiple linear regression was applied to evaluate the associations between selected factors and COVID-19 cases adjusting for covariates. Lastly, the relationship between environmental factors and mutation frequency was evaluated using the same correlation techniques mentioned above.</p><p><strong>Results: </strong>Among the 24,826 confirmed COVID-19 cases reported from 40 cities in China from January 23, 2020, to July 7, 2022, 98.4% (n=24,430) were found in the lowlands. Population density was positively correlated with COVID-19 cases in all regions (ρ=0.641, P=.003). In high-altitude areas, the number of COVID-19 cases was negatively associated with temperature, sunlight hours, and UV index (P=.003, P=.001, and P=.009, respectively) and was positively associated with wind speed (ρ=0.388, P<.001), whereas no correlation was found between meteorological factors and COVID-19 cases in the lowlands. After controlling for covariates, the mixed-effects model also showed positive associations of fine particulate matter (PM2.5) and carbon monoxide (CO) with COVID-19 cases (P=.002 and P<.001, respectively). Sequence variant analysis showed lower genetic diversity among nucleotides for each SARS-CoV-2 genome (P<.001) and three open reading frames (P<.001) in high altitudes compared to 300 sequences analyzed from low altitudes. Moreover, the frequencies of 44 nonsynonymous mutations and 32 synonymous mutations were significantly different between the high- and low-altitude groups (P<.001, mutation frequency>0.1). Key nonsynonymous mutations showed positive correlations with altitude, wind speed, and air pressure and showed negative correlations with temperature, UV index, and sunlight hours.</p><p><strong>Conclusions: </strong>By comparison with the lowlands, the number of confirmed COVID-19 cases was substantially lower in high-altitude regions of China, and the populatio
背景:新型冠状病毒 SARS-CoV-2 引发了全球 COVID-19 大流行。新的报告显示,高原地区的死亡率较低,病例数减少;然而,迄今为止,尚未就环境因素和病毒基因多样性对 COVID-19 感染率的累积影响进行比较研究:本研究旨在确定 COVID-19 在高海拔和低海拔地区感染率的差异,并探讨中国高海拔地区与低海拔地区流行趋势的差异是否受环境因素、人口密度和生物机制的影响:方法:我们通过线性回归研究了人口密度与 COVID-19 病例之间的相关性。方法:我们通过线性回归研究了人口密度与COVID-19病例之间的相关性,并应用零点模型确定了与COVID-19感染相关的可能因素。我们使用斯皮尔曼相关系数进一步分析了气象和空气质量因素与感染病例的相关性。混合效应多元线性回归用于评估选定因素与 COVID-19 感染病例之间的相关性,并对协变量进行调整。最后,利用上述相关技术评估了环境因素与变异频率之间的关系:结果:2020年1月23日至2022年7月7日,中国40个城市报告的24826例COVID-19确诊病例中,98.4%(n=24430)的病例发生在低洼地区。所有地区的人口密度与COVID-19病例数均呈正相关(ρ=0.641,P=.003)。在高海拔地区,COVID-19病例数与温度、日照时间和紫外线指数呈负相关(分别为P=.003、P=.001和P=.009),与风速呈正相关(ρ=0.388,P0.1)。关键的非同义突变与海拔、风速和气压呈正相关,与温度、紫外线指数和日照时数呈负相关:与低地相比,中国高海拔地区的 COVID-19 确诊病例数大幅减少,而人口密度、气温、日照时数、紫外线指数、风速、PM2.5 和 CO 均影响着高原地区的累积流行趋势。环境因素对SARS-CoV-2序列变异的影响增加了人们对海拔高度对COVID-19感染影响的认识,为预防干预提供了新的建议。
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引用次数: 0
Effectiveness of a Smartphone App to Promote Physical Activity Among Persons With Type 2 Diabetes: Randomized Controlled Trial. 智能手机应用程序对促进 2 型糖尿病患者体育锻炼的效果:随机对照试验
IF 2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-21 DOI: 10.2196/53054
Stephanie E Bonn, Madeleine Hummel, Giulia Peveri, Helén Eke, Christina Alexandrou, Rino Bellocco, Marie Löf, Ylva Trolle Lagerros
<p><strong>Background: </strong>Physical activity is well known to have beneficial effects on glycemic control and to reduce risk factors for cardiovascular disease in persons with type 2 diabetes. Yet, successful implementation of lifestyle interventions targeting physical activity in primary care has shown to be difficult. Smartphone apps may provide useful tools to support physical activity. The DiaCert app was specifically designed for integration into primary care and is an automated mobile health (mHealth) solution promoting daily walking.</p><p><strong>Objective: </strong>This study aimed to investigate the effect of a 3-month-long intervention promoting physical activity through the use of the DiaCert app among persons with type 2 diabetes in Sweden. Our primary objective was to assess the effect on moderate to vigorous physical activity (MVPA) at 3 months of follow-up. Our secondary objective was to assess the effect on MVPA at 6 months of follow-up and on BMI, waist circumference, hemoglobin A<sub>1c</sub>, blood lipids, and blood pressure at 3 and 6 months of follow-up.</p><p><strong>Methods: </strong>We recruited men and women with type 2 diabetes from 5 primary health care centers and 1 specialized center. Participants were randomized 1:1 to the intervention or control group. The intervention group was administered standard care and access to the DiaCert app at baseline and 3 months onward. The control group received standard care only. Outcomes of objectively measured physical activity using accelerometers, BMI, waist circumference, biomarkers, and blood pressure were assessed at baseline and follow-ups. Linear mixed models were used to assess differences in outcomes between the groups.</p><p><strong>Results: </strong>A total of 181 study participants, 65.7% (119/181) men and 34.3% (62/181) women, were recruited into the study and randomized to the intervention (n=93) or control group (n=88). The participants' mean age and BMI were 60.0 (SD 11.4) years and 30.4 (SD 5.3) kg/m<sup>2</sup>, respectively. We found no significant effect of the intervention (group by time interaction) on MVPA at either the 3-month (β=1.51, 95% CI -5.53 to 8.55) or the 6-month (β=-3.53, 95% CI -10.97 to 3.92) follow-up. We found no effect on any of the secondary outcomes at follow-ups, except for a significant effect on BMI at 6 months (β=0.52, 95% CI 0.20 to 0.84). However, mean BMI did not differ between the groups at the 6-month follow-up.</p><p><strong>Conclusions: </strong>We found no evidence that persons with type 2 diabetes being randomized to use an app promoting daily walking increased their levels of MVPA at 3 or 6 months' follow-up compared with controls receiving standard care. The effect of the app on BMI was unclear, and we found nothing to support an effect on secondary outcomes. Further research is needed to determine what type of mHealth intervention could be effective to increase physical activity among persons with type 2 diabetes.</p><
背景:众所周知,体育锻炼对 2 型糖尿病患者的血糖控制和减少心血管疾病的风险因素有好处。然而,在初级保健中成功实施以体育锻炼为目标的生活方式干预却很困难。智能手机应用程序可为支持体育锻炼提供有用的工具。DiaCert 应用程序是专为整合到初级保健中而设计的,是一种促进日常步行的自动化移动医疗(mHealth)解决方案:本研究旨在调查通过使用 DiaCert 应用程序对瑞典 2 型糖尿病患者进行为期 3 个月的体育锻炼干预的效果。我们的首要目标是评估随访 3 个月后中度到剧烈运动 (MVPA) 的效果。我们的次要目标是评估随访 6 个月时 MVPA 的效果,以及随访 3 个月和 6 个月时 BMI、腰围、血红蛋白 A1c、血脂和血压的效果:我们从 5 个初级保健中心和 1 个专科中心招募了男性和女性 2 型糖尿病患者。参与者按 1:1 随机分配到干预组或对照组。干预组接受标准护理,并在基线和 3 个月后使用 DiaCert 应用程序。对照组只接受标准护理。在基线和随访期间对使用加速度计客观测量的体力活动、体重指数、腰围、生物标志物和血压结果进行评估。采用线性混合模型评估组间结果的差异:研究共招募了 181 名参与者,其中男性占 65.7%(119/181),女性占 34.3%(62/181),他们被随机分配到干预组(93 人)或对照组(88 人)。参与者的平均年龄和体重指数分别为 60.0 (SD 11.4) 岁和 30.4 (SD 5.3) kg/m2。我们发现,在 3 个月(β=1.51,95% CI -5.53-8.55)或 6 个月(β=-3.53,95% CI -10.97-3.92)的随访中,干预(组与时间的交互作用)对 MVPA 均无明显影响。我们发现,除了 6 个月时对体重指数(BMI)有显著影响(β=0.52,95% CI 0.20 至 0.84)外,随访时对任何次要结果都没有影响。然而,在 6 个月的随访中,两组的平均体重指数并无差异:我们没有发现证据表明,与接受标准护理的对照组相比,随机使用促进每日步行的应用程序的 2 型糖尿病患者在 3 个月或 6 个月的随访中增加了 MVPA 水平。应用程序对体重指数的影响尚不明确,我们也没有发现对次要结果的影响。要确定哪种类型的移动医疗干预能有效增加 2 型糖尿病患者的体力活动,还需要进一步的研究:ClinicalTrials.gov NCT03053336; https://clinicaltrials.gov/study/NCT03053336.
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引用次数: 0
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Interactive Journal of Medical Research
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