Revista de Gastroenterologia de Mexico最新文献

英文中文

Respuesta a Pérez-Nieto et al., «Consideraciones sobre la recomendación de soluciones balanceadas en hemorragia variceal aguda» 对Perez -Nieto等人的答复，“关于建议对急性静脉曲张出血采取平衡解决办法的考虑”

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-10-01 DOI: 10.1016/j.rgmx.2025.09.003

J.A. Velarde-Ruiz Velasco , E.S. García-Jiménez , J.M. Aldana-Ledesma , F. Higuera-de la Tijera

引用次数: 0

Neoplasias neuroendocrinas gastro-entero-pancreáticas: Análisis clínico-patológico de 48 casos atendidos en el Hospital Ángeles del Pedregal de la Ciudad de México entre 2018 y 2024 胃-肠-胰腺神经内分泌肿瘤：2018年至2024年墨西哥城Angeles del Pedregal医院48例临床病理分析

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-10-01 DOI: 10.1016/j.rgmx.2025.02.004

R. Sánchez-Arreguín , M. Ahumada-Ayala , V. Santibañez-Silva , B. Bautista-Martínez , C. Gallegos-Garza

Introduction and aims

Neuroendocrine neoplasms are rare tumors accounting for approximately 2% of all neoplasms, most of which (62-70%) originate in the gastrointestinal tract and pancreas. Our primary aim was to describe the clinical presentation and pathologic features of these tumors, to improve our knowledge and early identification of them.

Materials and methods

A retrospective, cross-sectional, observational, and descriptive study was conducted on patients with a confirmed diagnosis of neuroendocrine neoplasm treated at the Hospital Ángeles del Pedregal within the time frame of 2018 and 2024. All cases diagnosed with neuroendocrine neoplasm of the pancreas or gastrointestinal tract in surgical specimens from the pathology service were included. The clinical, laboratory, and imaging data were obtained from the patients’ hospital charts.

Results

Mean patient age was 55.2 years (range: 21 to 88 years). Of the 48 cases, 28 were men and 20 were women. The most frequent locations of the neuroendocrine neoplasms were the pancreas (25%), stomach (16.6%), rectum (12.5%), and appendix (10.4%). In 23/48 (47.9%) cases, the diagnosis of neuroendocrine neoplasm was incidental during surgery, endoscopy, or in imaging studies.

Conclusions

The great variety of gastroenteropancreatic neuroendocrine neoplasms was described. Given that these tumors rarely produce a typical secretory syndrome, a high level of clinical suspicion is needed. Circulating biomarkers may be useful for their early diagnosis.

神经内分泌肿瘤是一种罕见的肿瘤，约占所有肿瘤的2%，其中大多数（62-70%）起源于胃肠道和胰腺。我们的主要目的是描述这些肿瘤的临床表现和病理特征，以提高我们的知识和早期识别。材料和方法回顾性、横断面、观察性和描述性研究对2018年至2024年期间在Ángeles del Pedregal医院治疗的确诊神经内分泌肿瘤患者进行了研究。所有病例诊断为胰腺或胃肠道神经内分泌肿瘤的手术标本病理服务包括在内。临床、实验室和影像学资料均来自患者的医院图表。结果患者平均年龄为55.2岁（21 ~ 88岁）。在48例病例中，28例为男性，20例为女性。神经内分泌肿瘤最常见的部位为胰腺（25%）、胃（16.6%）、直肠（12.5%）和阑尾（10.4%）。在23/48（47.9%）的病例中，神经内分泌肿瘤的诊断是在手术、内镜检查或影像学检查中偶然发现的。结论胃肠道胰腺神经内分泌肿瘤种类繁多。鉴于这些肿瘤很少产生典型的分泌综合征，需要高度的临床怀疑。循环生物标志物可能有助于早期诊断。

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引用次数: 0

La importancia de un adecuado reporte de la dieta en estudios de epidemiología nutricional 适当的饮食报告在营养流行病学研究中的重要性

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-10-01 DOI: 10.1016/j.rgmx.2025.05.001

S.E. Martínez-Vázquez , A. Kammar-García

引用次数: 0

Respuesta al comentario del artículo «Recomendaciones de buena práctica clínica en la prescripción y deprescripción de inhibidores de la bomba de protones. Revisión por expertos de la AMG» 对文章《质子泵抑制剂处方和抑制的良好临床实践建议》评论的回应。WAGGGS专家评审”。

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2025.06.001

L.R. Valdovinos-García

引用次数: 0

Frecuencia de adenomas serrados sésiles en pacientes con antecedente de cáncer colorrectal detectados durante colonoscopias de vigilancia 在结肠镜检查中发现有结肠直肠癌病史的患者中，静坐缝合腺瘤的发生率

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2024.11.008

J.P. Pérez-Macías, J.C. Sánchez-del Monte, A.I. Hernández-Guerrero, W.D. Torrecilla-Ramírez, B.A. Sánchez-Jiménez, G.M. Salgado-Castellón

Introduction

Sessile serrated adenomas (SSAs) are precursor lesions of colorectal cancer (CRC) in 15-30% of cases, but due to their subtle characteristics, their endoscopic detection is a challenge. The present work aimed to determine the frequency of SSAs in patients with a history of CRC who underwent index and surveillance colonoscopies after their cancer diagnosis.

Material and methods

An observational cohort study was conducted on patients diagnosed with CRC who underwent an index colonoscopy and at least two surveillance colonoscopies at the Instituto Nacional de Cancerología in Mexico City, between January 2015 and December 2018. Demographic and clinical variables and endoscopic findings were analyzed. SSA frequency was calculated as the number of patients with one or more SSAs divided by the total number of patients analyzed. Means were compared for the bivariate inferential analysis and the chi-square test and Fisher's exact test were used for the nominal variable analysis. Logistic regression was carried out to search for factors related to SSA.

Results

Four hundred patients were included; the mean patient age was 58 years and 52% were women. SSA frequency was 5.25%. Thirty-three percent of the SSAs were found in the index colonoscopy and 38% in subsequent colonoscopies. SSAs had a mean size of 5.52 mm, 84% were classified as Paris Is, 45% as KUDO II, and most were located in the ascending or transverse colon (21% and 20%, respectively).

Conclusions

SSAs are rare premalignant lesions, and their endoscopic diagnosis is a challenge. Their identification during the follow-up of patients with a history of CRC is essential for reducing the risk of metachronous progression.

无柄锯齿状腺瘤（SSAs）在15-30%的病例中是结直肠癌（CRC）的前体病变，但由于其微妙的特征，其内镜检测是一个挑战。本研究旨在确定有结直肠癌病史的患者在癌症诊断后接受指数和监测结肠镜检查时SSAs的频率。材料和方法在2015年1月至2018年12月期间，在墨西哥城国立医院Cancerología对诊断为结直肠癌的患者进行了一项观察性队列研究，这些患者接受了指数结肠镜检查和至少两次监测结肠镜检查。分析人口统计学和临床变量以及内窥镜检查结果。SSA频率计算为有一个或多个SSA的患者数除以所分析的患者总数。双变量推理分析采用均数比较，名义变量分析采用卡方检验和Fisher精确检验。采用Logistic回归方法寻找与SSA相关的因素。结果共纳入400例患者；患者平均年龄为58岁，52%为女性。SSA频率为5.25%。33%的ssa在第一次结肠镜检查中发现，38%在随后的结肠镜检查中发现。ssa平均大小为5.52 mm， 84%为Paris i型，45%为KUDO II型，多数位于升结肠或横结肠（分别占21%和20%）。结论sssa是一种罕见的恶性前病变，其内镜诊断具有一定的挑战性。在对有结直肠癌病史的患者进行随访时对其进行识别对于降低异时性进展的风险至关重要。

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引用次数: 0

Manifestaciones gastrointestinales en amiloidosis hereditaria por transtirretina (AhTTR): reporte de caso 经螺旋体引起的遗传性淀粉样蛋白病（AhTTR）的胃肠道症状：病例报告

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2025.03.006

J.C. Peñafort-Zamora , A.C. Zamora-García , H. Hernández-Cortes , J.A. Pérez-Ríos , S. Villalon-Ávalos

引用次数: 0

Nuevas herramientas para la clasificación y puntuación de enfermedad por reflujo gastroesofágico 胃食管反流疾病分类和评分的新工具

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2025.05.005

S. Siboni , M. Sozzi , P. Visaggi , R. De Maron , E. Asti

Gastroesophageal reflux disease (GERD) is a prevalent condition characterized by the retrograde flow of gastric contents into the esophagus, significantly impacting quality of life. Traditional diagnostic approaches often lack precision due to symptom overlap with other conditions. This review introduces the American Foregut Society (AFS) classification, Milan score, pHoenix score, COuGH RefluX score, and Lyon score, five novel tools designed to enhance the objectivity, reproducibility, and clinical relevance of GERD diagnosis.

The AFS classification refines the endoscopic assessment of esophagogastric junction (EGJ) integrity by incorporating measurable parameters (hiatal hernia length, hiatal aperture diameter, and flap valve), overcoming the subjectivity of the Hill classification. The Milan score, derived from high-resolution manometry, integrates four parameters (ineffective esophageal motility, EGJ-contractile integral, EGJ morphology, and straight leg raise response) to quantify anti-reflux barrier (ARB) disruption.

The pHoenix score, developed for prolonged wireless pH monitoring, weights supine AET more heavily, addressing limitations of the DeMeester score and Lyon 2.0 consensus. The COuGH RefluX score, a clinical prediction model for laryngopharyngeal symptoms, uses six parameters (cough, obesity, globus, hiatal hernia, regurgitation, male sex) to stratify GERD likelihood. Finally, the Lyon score integrates endoscopic and pH-impedance data, categorizing patients into phenotypes (from no GERD to severe GERD) and predicting treatment outcomes.

These tools collectively address diagnostic challenges by standardizing assessments and improving patient stratification. By reducing diagnostic ambiguity and guiding personalized therapy, these innovations hold promise for transforming GERD management, particularly in selecting candidates for escalated medical or surgical interventions.

胃食管反流病（GERD）是一种以胃内容物逆行流进食管为特征的常见疾病，严重影响生活质量。由于症状与其他疾病重叠，传统的诊断方法往往缺乏准确性。本文介绍了美国前肠学会（AFS）分类、米兰评分、凤凰评分、咳嗽反流评分和里昂评分，这五种新工具旨在提高GERD诊断的客观性、可重复性和临床相关性。AFS分类通过纳入可测量参数（裂孔疝长度、裂孔孔径直径和瓣瓣）来完善食管胃结（EGJ）完整性的内镜评估，克服了Hill分类的主观性。米兰评分来源于高分辨率测压法，整合了四个参数（无效食管运动、EGJ收缩积分、EGJ形态学和直腿抬高反应）来量化抗反流屏障（ARB）破坏。pHoenix评分是为长时间无线pH监测而开发的，它更重视仰卧AET，解决了DeMeester评分和Lyon 2.0共识的局限性。咳嗽反流评分是一种喉咽症状的临床预测模型，使用六个参数（咳嗽、肥胖、球体、裂孔疝、反流、男性）对反流可能性进行分层。最后，Lyon评分整合了内镜和ph阻抗数据，将患者分为表型（从无GERD到严重GERD），并预测治疗结果。这些工具通过标准化评估和改善患者分层来共同解决诊断挑战。通过减少诊断歧义和指导个性化治疗，这些创新有望改变胃食管反流病的管理，特别是在选择候选人进行升级的医疗或手术干预方面。

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引用次数: 0

Respuesta a «Trasplante de microbiota fecal en Clostridioides difficile recurrente: ¿es pertinente mayor rigor metodológico y el análisis de otras poblaciones?» 对“难治性梭状芽胞杆菌的粪便微生物移植：是否需要更严格的方法和对其他种群的分析？”»

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2025.06.002

P. Núñez, R. Quera, C. von Muhlenbrock

引用次数: 0

Revisión sistemática: efecto de los inhibidores de la bomba de protones sobre la fisiología de Helicobacter pylori 系统回顾：质子泵抑制剂对幽门螺杆菌生理机能的影响

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2024.12.006

V. Blandón-Arias , A.M. Ospina-Gil , B.E. Salazar-Giraldo , T.L. Pérez-Cala

Introduction and aims

Helicobacter pylori is a Gram-negative bacillus that colonizes the gastric mucosa and infects more than half of the world population. Treatment consists of two antibiotics and a proton pump inhibitor (PPI) that favors the replication of the bacterium and enhances the activity of the antibiotics. Despite the importance of proton pump inhibitor use in treating H. pylori infection, the precise mechanisms through which PPIs affect the physiology of the bacterium are not yet understood.

Aim

Our aim was to compile information pertaining to the effect of PPIs on the physiology of H. pylori and the mechanisms through which they produce alterations in the bacterium.

Methods

A bibliographic search was conducted, utilizing the PubMed, Science Direct, and LILACS databases, and included preclinical and clinical original articles published in any language.

Results

The sulfenamide form of PPIs was shown to have effects on H. pylori, including the induction of structural changes, inhibition of bacterial growth, and interference with enzymes, such as urease, ATPases, and alcohol dehydrogenase.

Conclusions

The binding of the sulfenamide form of PPIs to the bacterial structural and enzymatic components was the main mechanism through which H. pylori physiology was altered in vitro, but how they induce alterations in the bacterium was not established in the clinical studies analyzed.

幽门螺杆菌是一种革兰氏阴性杆菌，定植于胃粘膜，感染世界上一半以上的人口。治疗包括两种抗生素和质子泵抑制剂（PPI），有利于细菌的复制和增强抗生素的活性。尽管质子泵抑制剂在治疗幽门螺杆菌感染中的重要性，但PPIs影响细菌生理的确切机制尚不清楚。我们的目的是收集有关PPIs对幽门螺杆菌生理影响的信息，以及它们在细菌中产生改变的机制。方法利用PubMed、Science Direct和LILACS数据库进行文献检索，检索所有语种的临床前和临床原始文献。结果PPIs的磺胺形式对幽门螺杆菌有影响，包括诱导结构改变，抑制细菌生长，干扰酶，如脲酶、三磷酸腺苷酶和乙醇脱氢酶。结论PPIs的亚砜酰胺形式与细菌结构和酶的结合是体外改变幽门螺杆菌生理的主要机制，但在临床研究中尚未确定它们如何诱导细菌的改变。

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引用次数: 0

Melanosis del esófago: una entidad rara 食道黑色素瘤：罕见的实体

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico

Pub Date : 2025-07-01 DOI: 10.1016/j.rgmx.2025.03.009

L.M. Relvas , S. Barros , I. Carvalho , A.J. Cadillá , F. Velasco

引用次数: 0

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