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Morphofunctional characteristics of the pancreas after administration of N-acetylcysteine in an acute post-radiation pancreatitis model 在急性放射后胰腺炎模型中服用 N-乙酰半胱氨酸后胰腺的形态功能特征
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-12-22 DOI: 10.17816/morph.623166
G. Demyashkin, Tatyana Dubovaya, Dali Ugurchieva, M. Vadyukhin, Pinara Akhmedova, Valeria Simagina
BACKGROUND: The development of effective methods of non-drug and drug protection of humans and animals from the effects of ionizing radiation remains relevant. It is necessary to conduct a morphofunctional assessment of changes in the pancreatic parenchyma and identify the degree of radiosensitization of acinocytes and insulocytes outside the tumor, as well as during electron therapy of cancer of neighboring organs, such as the colon, stomach, etc. AIM: morphological assessment of the pancreas after administration of N-acetylcysteine in a model of acute radiation-induced pancreatitis. METHODS: Wistar rats (Rattus Wistar; n=40) were divided into four experimental groups: I control (n=10); II (n=10) fractional irradiation with electrons in a total irradiation dose of 25 Gy; III (n=10) administration of N-acetylcysteine before electron irradiation; IV (n=10) administration of N-acetylcysteine. Animals of all groups (I IV) were removed from the experiment a week after the last fraction. RESULTS: A week after electron irradiation in group II, a disturbance in histoarchitecture was observed, due to the presence of signs of acute post-radiation pancreatitis. This was accompanied by increases in glucose, amylase and malondialdehyde levels, as well as decreases in insulin and superoxide dismutase levels. During the administration of N-acetylcysteine in group III, less pronounced depth and range of damage to the pancreas was noted. CONCLUSION: As a result of the morphofunctional study of the pancreas after irradiation with electrons against the background of the administration of N-acetylcysteine, it can be considered quite reasonable to conclude that it is advisable to conduct further studies of the protective effects of this drug when exposed to ionizing radiation using immunohistochemical, molecular genetic and other methods.
背景:开发有效的非药物和药物保护方法,使人类和动物免受电离辐射的影响仍然具有现实意义。有必要对胰腺实质的变化进行形态功能评估,并确定肿瘤外以及结肠、胃等邻近器官癌症电子治疗期间胰岛素细胞和胰岛素细胞的放射致敏程度。目的:在急性辐射诱发胰腺炎模型中服用 N-乙酰半胱氨酸后对胰腺进行形态学评估。方法:将 Wistar 大鼠(Rattus Wistar;n=40)分为四个实验组:I 对照组(n=10);II(n=10)用电子进行部分照射,总照射剂量为 25 Gy;III(n=10)在电子照射前服用 N-乙酰半胱氨酸;IV(n=10)服用 N-乙酰半胱氨酸。所有组别(I IV)的动物在最后一次电子辐照一周后退出实验。结果:第二组动物在接受电子辐照一周后,由于出现急性辐照后胰腺炎的症状,组织结构出现紊乱。与此同时,葡萄糖、淀粉酶和丙二醛水平升高,胰岛素和超氧化物歧化酶水平下降。第三组患者在服用 N-乙酰半胱氨酸期间,胰腺受损的深度和范围均有所减轻。结论:在服用 N-乙酰半胱氨酸的背景下,对电子辐照后胰腺的形态功能进行研究的结果表明,利用免疫组化、分子遗传学和其他方法对该药物在电离辐射下的保护作用进行进一步研究是非常合理的。
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引用次数: 0
Tissues in the body system. Tissue science - histology - in the system of biomedical scientific and educational disciplines 人体系统中的组织。生物医学科学和教育学科体系中的组织科学--组织学
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-12-20 DOI: 10.17816/morph.624206
Nikolai Shevlyuk, Alexander Abramovich Stadnikov
The article covers the formation and development of histology – the science of tissues - shows the formation of ideas about tissues, and provides information on the classification of tissues. The term "tissue” was first introduced into scientific vocabulary in 1671 by the English botanist and physician N. Grew (1641 – 1712) when describing the microscopic structure of plant organs. In the 50s of the 19th century, German histologists R.A. Kölliker (1817 – 1905) and F. Leydig (1821 – 1908) laid the foundations for the current scientific classification of tissues. These authors distinguished 4 main groups of tissues: epithelium, connective tissue and blood, nervous tissue, muscle tissue. Russian scientists A.A. Zavarzin and N.G. Khlopin made a great contribution to the development of problems of classification and evolution of tissues. It should be noted that the term “tissue,” initially understood as purely morphological, also received its physiological content, that is, the concept of “tissue” became a morphofunctional concept. One of the leading paradigms of histology is the idea of tissue stability at the stages of ontogenesis of organisms. Variability of fabrics is allowed within certain limits, within the tissue group to which the fabric belongs. There is no convincing evidence of the transition of tissue from one tissue group to any other. The first departments of histology arose in European higher educational institutions in the middle of the 19th century, and in higher educational institutions in Russia in the late 60s of the 19th century. Histology as a scientific discipline has not exhausted the reserve of its capabilities, therefore the exclusion of histology from the nomenclature of scientific specialties is incorrect.
这篇文章涵盖了组织学--研究组织的科学--的形成和发展,展示了有关组织的观念的形成,并提供了有关组织分类的信息。1671 年,英国植物学家和医生 N. 格鲁(1641 - 1712 年)在描述植物器官的显微结构时,首次将 "组织 "一词引入科学词汇。19 世纪 50 年代,德国组织学家 R.A. Kölliker(1817 - 1905 年)和 F. Leydig(1821 - 1908 年)为当前的组织科学分类奠定了基础。这些作者将组织分为 4 大类:上皮、结缔组织和血液、神经组织、肌肉组织。俄罗斯科学家 A.A. Zavarzin 和 N.G. Khlopin 对组织分类和进化问题的发展做出了巨大贡献。需要指出的是,"组织 "一词最初被理解为纯粹的形态学概念,后来也被赋予了生理学内涵,也就是说,"组织 "概念变成了形态功能概念。组织学的主要范式之一是生物体本体发生阶段的组织稳定性思想。在织物所属的组织组中,允许织物在一定范围内发生变化。没有令人信服的证据表明组织会从一个组织组过渡到其他组织组。19 世纪中叶,欧洲高等院校出现了第一批组织学专业,19 世纪 60 年代末,俄罗斯高等院校也出现了组织学专业。组织学作为一门科学学科,其能力储备尚未耗尽,因此将组织学排除在科学专业名称之外是不正确的。
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引用次数: 0
Contribution of Vladimir Lazarevich Bykov (1947 – 2022) to the development of Russian histology, cytology and embryology 弗拉基米尔-拉扎列维奇-别科夫(1947 - 2022)对俄罗斯组织学、细胞学和胚胎学发展的贡献
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-12-19 DOI: 10.17816/morph.624203
Nikolai Shevlyuk
The paper highlights the main stages of the life and work of the outstanding Russian scientist and teacher Vladimir Lazarevich Bykov. His scientific research was devoted to a wide range of fundamental and applied problems of histology, cytology, embryology and pathomorphology (histophysiology of the thyroid gland, pathomorphology of various organs with candidiasis, morphofunctional characteristics of the oral cavity organs, analysis of the protective mechanisms of the mucous membranes of the digestive organs, history of morphology, methods of teaching histology, cytology and embryology). The library of educational literature on histology, cytology and embryology created by him represents a modern encyclopedic body of knowledge on these academic disciplines. His contribution as a member of the editorial board (1992 – 2022) and editor–in-chief of the journal «Morphology» in 2002 - 2016 is invaluable.
本文重点介绍了俄罗斯杰出科学家和教师弗拉基米尔-拉扎列维奇-别科夫(Vladimir Lazarevich Bykov)生活和工作的主要阶段。他的科学研究致力于组织学、细胞学、胚胎学和病理形态学的广泛基础和应用问题(甲状腺的组织生理学、患有念珠菌病的各种器官的病理形态学、口腔器官的形态功能特征、消化器官粘膜保护机制分析、形态学史、组织学、细胞学和胚胎学的教学方法)。他创建的组织学、细胞学和胚胎学教育文献图书馆代表了这些学科的现代百科全书式知识体系。他作为《形态学》杂志编委会成员(1992 - 2022 年)和主编(2002 - 2016 年)所做的贡献弥足珍贵。
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引用次数: 0
Morphological features of the innervation of the rat adrenal gland adipose tissue 大鼠肾上腺脂肪组织神经支配的形态特征
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-12-11 DOI: 10.17816/morph.607423
Eugene Ivanovich Chumasov, E. S. Petrova, D. E. Korzhevskii
BACKGROUND: The relevance of studying adipose tissue is due to the lack of knowledge about the etiology and pathogenesis of obesity and the lack of research into the endocrine function of adipose tissue. Questions about the structure, functions, and innervation characteristics of white and brown adipose tissue of the adrenal gland are the least studied. AIM: The purpose of this study was to study the structure and innervation of rat adrenal adipose tissue using neuroimmunohistochemical markers. METHODS: Using immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase and synaptophysin, performed on paraffin sections, the innervation of the adipose tissue of the rat adrenal gland was studied (n=10). RESULTS: Unmyelinated nerve fibers, as well as catecholaminergic and cholinergic nerve terminal apparatuses, were identified in the white and brown adipose tissue of the rat adrenal gland. It has been shown that parasympathetic and sympathetic postganglionic nerve fibers penetrate adipose tissue through arterial vessels. There, Remakov's varicose axons intensively branch and form terminal synaptic networks of the en passant type, which are involved in the innervation of adipocytes in white and brown adipose tissue. Most sympathetic and parasympathetic synaptic structures are localized in brown and mixed adipose tissue. Sympathetic fibers are in close connection with the wall of arterial vessels and contact brown adipocytes. In white adipose tissue, varicose axons are found mainly around arterial vessels and are rarely found between differentiated ring-shaped adipocytes. CONCLUSION: The noted differences in the sympathetic innervation of white and brown adipose tissue are due to the fact that, unlike white adipocytes, brown adipose tissue cells perform a secretory function. By producing adipokines, they influence the production of corticosteroids by the adrenal gland. The findings suggest that this process is under the control of the sympathetic nervous system
背景:研究脂肪组织的意义在于缺乏对肥胖症病因和发病机制的了解,以及缺乏对脂肪组织内分泌功能的研究。关于肾上腺白色脂肪组织和棕色脂肪组织的结构、功能和神经支配特点的问题是研究最少的。目的:本研究旨在利用神经免疫组化标记研究大鼠肾上腺脂肪组织的结构和神经支配。方法:使用石蜡切片对 PGP 9.5 蛋白、酪氨酸羟化酶和突触素进行免疫组化反应,研究大鼠肾上腺脂肪组织的神经支配(n=10)。结果:在大鼠肾上腺的白色和棕色脂肪组织中发现了无髓鞘神经纤维以及儿茶酚胺能和胆碱能神经末梢装置。研究表明,副交感神经和交感神经节后神经纤维可通过动脉血管穿透脂肪组织。在那里,雷马科夫曲张轴突密集分支并形成终末突触网络,参与白色和棕色脂肪组织中脂肪细胞的神经支配。大部分交感和副交感神经突触结构位于棕色和混合脂肪组织中。交感神经纤维与动脉血管壁紧密相连,并与棕色脂肪细胞接触。在白色脂肪组织中,曲张轴突主要分布在动脉血管周围,很少出现在分化的环形脂肪细胞之间。结论:白色脂肪组织和棕色脂肪组织的交感神经支配之所以存在明显差异,是因为棕色脂肪组织细胞与白色脂肪细胞不同,具有分泌功能。它们通过分泌脂肪因子,影响肾上腺分泌皮质类固醇。研究结果表明,这一过程受交感神经系统控制
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引用次数: 0
epresentation in the mental lexicon of Korean prefinal endings 韩国语前置词尾在心理词典中的表征
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.195
Chanyoung Lee
A 'priming lexical decision task' and a 'self-paced reading task' were conducted to investigate the representation in the mental lexicon of Korean prefinal endings. We observed the extent to which prefinal endings are likely to have their own representation in the lexicon according to three factors: 'type of prefinal ending,' 'frequency of the stem,' and 'frequency of conjunction between prefinal endings and final endings,' and found that prefinal endings with high-frequency stems were significantly more likely to have their own representation than those with low-frequency stems. The type of prefinal ending and the frequency of conjunction between prefinal endings and final endings had no significant effect on the likelihood of being represented independently, and the entire conjugation was more likely to be represented. The experimental results suggest that Korean speakers' mental lexicon has a dual structure of a surface lexicon and a deep lexicon, in which all lexical conjugations are stored in the surface lexicon, and some conjugations containing high-frequency stems are separated into stems and endings and stored in the deep lexicon, where they function as objects of reference.
我们进行了一项 "引导词汇决定任务 "和一项 "自定步调阅读任务",以研究韩语前置词尾在心理词典中的表征。我们根据三个因素观察了前置词尾在词库中的表征程度:我们发现,高频词干的前置词尾拥有自己的表征的可能性明显高于低频词干的前置词尾。前置词尾的类型以及前置词尾和词尾之间的连词频率对独立表征的可能性没有显著影响,而整个连词更有可能被表征。实验结果表明,韩国语者的心理词典具有表层词典和深层词典的双重结构,其中所有的词汇连接词都存储在表层词典中,而一些含有高频词干的连接词则被分离成词干和词尾,存储在深层词典中,作为参照对象发挥作用。
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引用次数: 0
-Ulkel and -malta suppletion -Ulkel和-malta补充剂
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.98
Soyoung Park
This paper presents a morpho-syntactic analysis of the realization patterns of negation suppletion -malta, which vary depending on the meanings of -ulkel, an ending ambiguous between expressing regret and conjecture. It argues that the occurrence of the negation suppletion form is conditioned by deontic modality within a local C-command relation. Consequently, -ulkel with a regretful meaning is linked to deontic modality, while -ulkel with a conjectural meaning corresponds to epistemic modality. In addition, it claims that -ulkel, depending on the two interpretations, occupies distinct syntactic positions, thereby leading to their contrasting grammatical properties.
本文对否定补语-malta 的实现模式进行了形态句法分析,其实现模式因-ulkel 的意义不同而不同,-ulkel 是一个在表示遗憾和猜测之间模棱两可的词尾。该研究认为,否定补语形式的出现是以局部 C 命令关系中的语气模态为条件的。因此,带有遗憾意义的-ulkel 与行为模态相关联,而带有猜测意义的-ulkel 则与认识模态相对应。此外,它还声称,根据这两种解释,-ulkel 占据了不同的句法位置,从而导致了它们截然不同的语法属性。
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引用次数: 0
Again, Looking for the nominative case marker -seo: focus on M. Kim(2009) and C. Kim(2010) 再次,寻找名格标记-seo:关注 M. Kim(2009 年)和 C. Kim(2010 年)。
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.235
Yong-Kun Ko
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引用次数: 0
Revisiting the case marker -seo: the meaning of activeness (and hamkke) 重新审视案例标记-seo:积极性(和 hamkke)的含义
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.243
Chungmin Lee
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引用次数: 0
Morphological Reanalysis of Word-Formation Elements 词形要素的形态学再分析
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.139
Meng-xiao Wang
Recently, it has been frequently observed in the Korean language that a portion of a word actively participates in the process of word formation in a fixed form. However, there is a lack of clear discussions regarding the morphological status of this “fixed element” whether it has a morphological status, what kind of morphological status it possesses if it does, and how it is formed. Therefore, this study aims to argue that such “fixed elements” can have a morphological status. By focusing on the phenomenon where elements that were previously used as part of a word appear productively in the process of word formation and acquire new function, the study aims to typologize how they are formed and what they become based on morphological reanalysis. These results suggest that fixed elements that were not morphemes in the process of neologism formation become “combining form”.
最近,在韩语中经常可以观察到词的一部分以固定的形式积极参与构词过程。然而,关于这种 "固定语素 "的形态地位,它是否具有形态地位,如果具有形态地位,它具有什么样的形态地位,以及它是如何形成的,都缺乏明确的讨论。因此,本研究旨在论证这种 "固定元素 "可以具有形态地位。本研究通过关注以前作为词的一部分的语素在组词过程中出现并获得新功能的现象,旨在根据形态学再分析,对这些语素的形成过程及其功能进行类型化。这些结果表明,在新词形成过程中,原本不是语素的固定语素变成了 "组合形式"。
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引用次数: 0
A study on the non-epistemic modal meaning of ‘-l pephata’ and ‘-l manhata’ 关于"-l pephata "和"-l manhata "的非表义情态意义的研究
IF 1.4 Q1 Arts and Humanities Pub Date : 2023-11-30 DOI: 10.51157/kmor.2023.25.2.167
Jonghyeok Lee
The purpose of this paper is to identify semantic characteristics of non-epistemic modality realized by ‘-l pephata’ and ‘-l manhata’. Modality can be divided into epistemic modality and root modality, which is non-epistemic modality. Epistemic modality expresses a speaker's judgment on the degree of factuality of the proposition, and root modality expresses the speaker's judgment on the likelihood of the state-of-affair. Some previous studies have seen that ‘-l pephata’ and ‘-l manhata’ express the judgment that it is possible for a situation to occur, which can be seen as pointing out that ‘-l pephata’ and ‘-l manhata’ represent the root modality. Root possibility meaning of ‘-l pephata’ and ‘-l manhata’ is analyzed by three criteria: ‘scope of the modal meaning’, ‘source of possibility’, and ‘potential barrier’. Root possibility expressed by ‘-l pephata’ corresponds to the [general situation possibility], which is wide-scope, has an external source, and has no potential barrier. In addition to the [general situation possibility], ‘-l manhata’ can express [Ability] which is narrow-scope, has an internal source. ‘-l pephata’ and ‘-l manhata’ which express [general situation possibility] differs in that ‘-l pephata’ expresses a judgement based on assimilated knowledge, whereas ‘-l manhata’ expresses a judgement based on unassimilated knowledge.
本文旨在确定"-l pephata "和"-l manhata "实现的非表义模态的语义特征。模态可分为认识模态和词根模态(即非认识模态)。认识模态表达了说话人对命题事实性程度的判断,而根模态表达了说话人对事态可能性的判断。以往的一些研究认为,"-l pephata "和"-l manhata "表达的是对某一情境有可能发生的判断,这可以看作是指出了"-l pephata "和"-l manhata "代表的是词根模态。通过三个标准来分析"-l pephata "和"-l manhata "的词根可能性意义:模态意义的范围"、"可能性的来源 "和 "潜在障碍"。由'-l pephata'表达的根可能性对应于[一般情况可能性],它范围广,有外部来源,没有潜在障碍。除了[一般情况可能性],'-l manhata'还可以表达[能力],它范围窄,有内部来源。表达[一般情况可能性]的'-l pephata'和'-l manhata'的不同之处在于,'-l pephata'表达的是基于同化知识的判断,而'-l manhata'表达的是基于非同化知识的判断。
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引用次数: 0
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Morphology
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