Pub Date : 2024-01-01Epub Date: 2022-08-30DOI: 10.1007/s12291-022-01085-1
Shirin Farheen, Mubeena Mariyath Pm, Suhailur Rehman, Md Fakhrul Hoda, Yakhlesh Gupta, Asif Ali, Kunzang Chosdol, Mehdi H Shahi
Meningioma is a common brain tumour which has neither a specific detection nor treatment method. The Sonic hedgehog (Shh) cell signaling pathway is a crucial regulatory pathway of mammalian organogenesis and tumorigenesis including meningioma. Shh cell signalling pathway cascade function by main transcription factor Gli1 and which further regulates in its downstream to Pax6 and Nkx2.2. This current study is aimed to explore the regulation of the Sonic hedgehog-Gli1 cell signaling pathway and its potential downstream targets in meningioma samples. A total of 24 surgically resected meningioma samples were used in this current study.Cytological changes were assessed using electron microscopic techniques as well as hematoxylin & eosin and DAPI staining. The expression pattern of Gli1, Nkx2.2 and Pax6 transcription factors were determined by using immunohistochemistry. The mRNA expression was assessed using RT-qPCR assays. Later, the whole transcriptome analysis of samples was performed with the amploseq technique. Results were compared with those obtained in normal human brain tissue (or normal meninges). Compared to the normal human brain tissue, meningioma samples showed crowded nuclei with morphological changes. Transcription factor Nkx2.2 expressed highly in all samples (24/24, 100%). Twenty-one of the 24 meningiomas (88%) showed high Gli1 and Pax6 expression. Whole transcriptome analysis of two meningioma samples also exhibited a very high increase in Gli1 expression signal in meningioma samples as compare to normal control. Hence, we may conclude that the Shh-Gli1 pathway is aberrantly activated in meningioma cells and is canonically upregulating the expression of transcription factors Pax6 and Nkx2.2.
Supplementary information: The online version contains supplementary material available at 10.1007/s12291-022-01085-1.
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Pub Date : 2023-10-16DOI: 10.1080/02619288.2023.2267951
Kenneth Lunn
{"title":"Aliens: the chequered history of Britain’s wartime refugees <b>Aliens: the chequered history of Britain’s wartime refugees</b> , Paul Dowswell, London, Biteback Publishing, 2023, 292 pp., £25 (hardback), ISBN: 978-1-78590-793-7","authors":"Kenneth Lunn","doi":"10.1080/02619288.2023.2267951","DOIUrl":"https://doi.org/10.1080/02619288.2023.2267951","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"220 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136114140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.1080/02619288.2023.2238400
H. Lopes
{"title":"Chinese Sojourners in Wartime Raj","authors":"H. Lopes","doi":"10.1080/02619288.2023.2238400","DOIUrl":"https://doi.org/10.1080/02619288.2023.2238400","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75008794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.1080/02619288.2023.2232345
D. Hall, Loretta Dynan
{"title":"Returning to Ireland from Australia 1880-1925","authors":"D. Hall, Loretta Dynan","doi":"10.1080/02619288.2023.2232345","DOIUrl":"https://doi.org/10.1080/02619288.2023.2232345","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"8 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78984337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.1080/02619288.2023.2233863
Anne J. Kershen
{"title":"Chapters of Accidents: A Writer’s Memoir","authors":"Anne J. Kershen","doi":"10.1080/02619288.2023.2233863","DOIUrl":"https://doi.org/10.1080/02619288.2023.2233863","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"8 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87576008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.1080/02619288.2023.2216683
Cristian Cercel
{"title":"The persistence and malleability of settlerness: Danube Swabians in Entre Rios/Guarapuava (Paraná, Brazil)","authors":"Cristian Cercel","doi":"10.1080/02619288.2023.2216683","DOIUrl":"https://doi.org/10.1080/02619288.2023.2216683","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"3 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79715272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-21DOI: 10.1080/02619288.2023.2198364
Matthew Stibbe
{"title":"NS-Verfolgte nach der Befreiung: Ausgrenzungserfahrungen und Neubeginn","authors":"Matthew Stibbe","doi":"10.1080/02619288.2023.2198364","DOIUrl":"https://doi.org/10.1080/02619288.2023.2198364","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"40 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78219394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-26DOI: 10.1080/02619288.2022.2138170
Liam John Liburd
{"title":"Global White Nationalism: From Apartheid to Trump","authors":"Liam John Liburd","doi":"10.1080/02619288.2022.2138170","DOIUrl":"https://doi.org/10.1080/02619288.2022.2138170","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"2015 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73905515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.1080/02619288.2022.2124732
Matthew Stibbe
{"title":"‘Feindliche Ausländer’ im Deutschen Reich während des Ersten Weltkrieges","authors":"Matthew Stibbe","doi":"10.1080/02619288.2022.2124732","DOIUrl":"https://doi.org/10.1080/02619288.2022.2124732","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"231 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76437904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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