Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-5-14
K. K. Tikhomirova, S. M. Kharit
The World Health Organization announced on May 4, 2023 that coronavirus infection is no longer a global emergency, but despite this, it proposed a strategy for 2023-2025 that includes the definition of immunization principles by each country, the need for case registrations and surveillance behind the virus. The review article presents data on high-risk groups for a severe course of a SARS-CoV-2 and new approaches to vaccination and revaccination recommended by WHO on depending on risk factors in patients and circulating new strains of the virus.
{"title":"Do we need coronavirus vaccination today?","authors":"K. K. Tikhomirova, S. M. Kharit","doi":"10.22625/2072-6732-2023-15-3-5-14","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-5-14","url":null,"abstract":"The World Health Organization announced on May 4, 2023 that coronavirus infection is no longer a global emergency, but despite this, it proposed a strategy for 2023-2025 that includes the definition of immunization principles by each country, the need for case registrations and surveillance behind the virus. The review article presents data on high-risk groups for a severe course of a SARS-CoV-2 and new approaches to vaccination and revaccination recommended by WHO on depending on risk factors in patients and circulating new strains of the virus.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-15-28
D. V. Kapustin, E. I. Krasnova, N. I. Khokhlova, O. M. Shishkova, L. L. Pozdnyakova
The literature review highlights modern ideas about the pathogenesis, pathomorphology, and clinical manifestations of central nervous system damage in patients with HIV infection, and also touches on the problems of diagnosis and treatment of these opportunistic infections. Particular attention should be paid to patients with severe immunodeficiency (CD4+T-lymphocyte count < 200 cl/ml) due to the high risk of secondary diseases of the central nervous system. Along with the etiological verification of opportunistic diseases of the central nervous system, magnetic resonance imaging of the brain is important at the initial stage of diagnosis, with the help of which it is possible to identify changes in the brain substance characteristic of certain pathogens. In addition to the basic etiotropic therapy of opportunistic infections in HIV patients, effective antiretroviral therapy and its index of penetration into the central nervous system play a crucial role.
{"title":"Modern aspects of central nervous system damage in patients with HIV infection (literature review)","authors":"D. V. Kapustin, E. I. Krasnova, N. I. Khokhlova, O. M. Shishkova, L. L. Pozdnyakova","doi":"10.22625/2072-6732-2023-15-3-15-28","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-15-28","url":null,"abstract":"The literature review highlights modern ideas about the pathogenesis, pathomorphology, and clinical manifestations of central nervous system damage in patients with HIV infection, and also touches on the problems of diagnosis and treatment of these opportunistic infections. Particular attention should be paid to patients with severe immunodeficiency (CD4+T-lymphocyte count < 200 cl/ml) due to the high risk of secondary diseases of the central nervous system. Along with the etiological verification of opportunistic diseases of the central nervous system, magnetic resonance imaging of the brain is important at the initial stage of diagnosis, with the help of which it is possible to identify changes in the brain substance characteristic of certain pathogens. In addition to the basic etiotropic therapy of opportunistic infections in HIV patients, effective antiretroviral therapy and its index of penetration into the central nervous system play a crucial role.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-29-38
N. A. Konyshko, L. I. Volynets, G. S. Konyshko
The aim of the review: to present up-to-date scientifically based information about the laboratory parameters of patients associated with severe SARS-CoV-2 infection and internal organ damage. Materials and methods: full-text publications of clinical, randomized and cohort studies, systematic reviews and meta-analyses from scientific databases PubMed, Elsevier, Scopus, Google Scholar, E-library for the period from 2019 to 2022 were analyzed. Results. Specific biomarkers were identified, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, IL6), hematological (number of lymphocytes and neutrophils, NLR, D-dimer, ferritin, RDW), myocardial (troponin, creatinekinase-MB, myoglobin), hepatic (AST, ALT, total bilirubin, albumin) and characterizing lung injury (KL-6), which can be used for risk stratification, as prognostic biomarkers of adverse clinical consequences, including death in patients with COVID-19. The studies demonstrated new biomarkers of inflammatory and systemic manifestations of COVID19: procalcitonin, calprotectin and presepsin.
{"title":"Laboratory markers of multiple organ pathology in severe cases and adverse outcomes of SARS-CoV-2 infection (systematic review)","authors":"N. A. Konyshko, L. I. Volynets, G. S. Konyshko","doi":"10.22625/2072-6732-2023-15-3-29-38","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-29-38","url":null,"abstract":"The aim of the review: to present up-to-date scientifically based information about the laboratory parameters of patients associated with severe SARS-CoV-2 infection and internal organ damage. Materials and methods: full-text publications of clinical, randomized and cohort studies, systematic reviews and meta-analyses from scientific databases PubMed, Elsevier, Scopus, Google Scholar, E-library for the period from 2019 to 2022 were analyzed. Results. Specific biomarkers were identified, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, IL6), hematological (number of lymphocytes and neutrophils, NLR, D-dimer, ferritin, RDW), myocardial (troponin, creatinekinase-MB, myoglobin), hepatic (AST, ALT, total bilirubin, albumin) and characterizing lung injury (KL-6), which can be used for risk stratification, as prognostic biomarkers of adverse clinical consequences, including death in patients with COVID-19. The studies demonstrated new biomarkers of inflammatory and systemic manifestations of COVID19: procalcitonin, calprotectin and presepsin.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-136-140
A. Yu. Komissarova, O. L. Tumash
This clinical case describes the manifestation of acute myeloid leukemia (AML) against the backdrop of severe COVID-19 infection in a teenage patient. The patient’s examination data, medical history, and available scientific literature on the relationship between COVID-19 and leukemia manifestation were studied and analyzed. COVID-19 infection in the context of AML was severe, with respiratory failure and involvement of more than 90% of the lungs according to computed tomography data. Changes observed in peripheral blood did not have specific alterations and only indirectly indicated an unfavorable premorbid background. This clinical case reflects the likelihood of the simultaneous presence of COVID-19 and other acute severe illnesses.
{"title":"A case of manifestation of acute myeloid leukemia in a teenager on the background of coronavirus infection COVID-19","authors":"A. Yu. Komissarova, O. L. Tumash","doi":"10.22625/2072-6732-2023-15-3-136-140","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-136-140","url":null,"abstract":"This clinical case describes the manifestation of acute myeloid leukemia (AML) against the backdrop of severe COVID-19 infection in a teenage patient. The patient’s examination data, medical history, and available scientific literature on the relationship between COVID-19 and leukemia manifestation were studied and analyzed. COVID-19 infection in the context of AML was severe, with respiratory failure and involvement of more than 90% of the lungs according to computed tomography data. Changes observed in peripheral blood did not have specific alterations and only indirectly indicated an unfavorable premorbid background. This clinical case reflects the likelihood of the simultaneous presence of COVID-19 and other acute severe illnesses.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-141-145
A. A. Garbuzov, Yu. A. Fedkina, A. L. Bairakova, O. L. Timchenko, D. A. Khavkina, T. A. Ruzhentsova, P. V. Chukhliaev
The article describes a clinical case of serous meningitis in a patient with confirmed hemorrhagic fever with renal syndrome (HFRS). Despite the moderate-severe course of the disease with moderate hemorrhagic syndrome, the patient had the development of acute renal failure with the simultaneous occurrence of a rare complication – inflammation of the meningeal membranes caused by hantavirus.
{"title":"Meningitis of hantavirus etiology","authors":"A. A. Garbuzov, Yu. A. Fedkina, A. L. Bairakova, O. L. Timchenko, D. A. Khavkina, T. A. Ruzhentsova, P. V. Chukhliaev","doi":"10.22625/2072-6732-2023-15-3-141-145","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-141-145","url":null,"abstract":"The article describes a clinical case of serous meningitis in a patient with confirmed hemorrhagic fever with renal syndrome (HFRS). Despite the moderate-severe course of the disease with moderate hemorrhagic syndrome, the patient had the development of acute renal failure with the simultaneous occurrence of a rare complication – inflammation of the meningeal membranes caused by hantavirus.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-128-135
V. T. Hoang, A. A. Kuzin, A. E. Zobov, T. T. Ha, A. A. Zobovа
Aim: To identify regional epidemiological features of dengue fever and substantiate approaches to conducting epidemiological surveillance for this infection taking into account the regional features of its distribution and risk factors affecting its formation. Materials and methods: Retrospective epidemiological analysis of dengue incidence in the provinces of the Socialist Republic of Vietnam from 2017 to 2022. To conduct the epidemiological analysis of dengue incidence, a free version of the GIS Axioms (ГИС Аксиомы) program and the Google Earth application were used. Results: It was noted that cases of dengue fever were registered in all 63 provinces of the country, however, the dynamics of incidence levels had wide spatial and temporal ranges. Excepting Hanoi (189.6 0/0000), dengue incidence in the northern provinces are lower than those in the southern provinces. The highest average long-term incidence of dengue fever was observed in Da Nang (659.8 0 / 0000 ), Binh Duong (623.3 0 / 0000 ), Quang Binh (565.5 0 / 0000 ), Ba Ria-Vung Tau (554.6 0 / 0000 ) and Khanh Hoa (544.8 0 / 0000 ). The results of a comparative analysis of dengue incidence and the main factors influencing it in the adjacent, the incidences of dengue fever of which are significantly different from each other, are shown. The application of geoinformation systems for epidemiological analysis has been demonstrated. It has been established that the distribution of the population of Vietnam differs greatly between the administrative regions of the country, and the use of population density for epidemiological analysis and forecasting of the epidemiological situation of infectious diseases, including dengue fever, can lead to incorrect results. Conclusion: The epidemiological situation of dengue fever in Vietnam is characterized by high incidence rates, their wide ranges of spatial and temporal variability, and geographical heterogeneity. The use of GIS technologies is one of the promising approaches for epidemiological analysis and monitoring of dengue fever, as well as other infectious diseases.
{"title":"Experience in conducting an epidemiological analysis of dengue incidence in the Socialist Republic of Vietnam using geographic information systems","authors":"V. T. Hoang, A. A. Kuzin, A. E. Zobov, T. T. Ha, A. A. Zobovа","doi":"10.22625/2072-6732-2023-15-3-128-135","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-128-135","url":null,"abstract":"Aim: To identify regional epidemiological features of dengue fever and substantiate approaches to conducting epidemiological surveillance for this infection taking into account the regional features of its distribution and risk factors affecting its formation. Materials and methods: Retrospective epidemiological analysis of dengue incidence in the provinces of the Socialist Republic of Vietnam from 2017 to 2022. To conduct the epidemiological analysis of dengue incidence, a free version of the GIS Axioms (ГИС Аксиомы) program and the Google Earth application were used. Results: It was noted that cases of dengue fever were registered in all 63 provinces of the country, however, the dynamics of incidence levels had wide spatial and temporal ranges. Excepting Hanoi (189.6 0/0000), dengue incidence in the northern provinces are lower than those in the southern provinces. The highest average long-term incidence of dengue fever was observed in Da Nang (659.8 0 / 0000 ), Binh Duong (623.3 0 / 0000 ), Quang Binh (565.5 0 / 0000 ), Ba Ria-Vung Tau (554.6 0 / 0000 ) and Khanh Hoa (544.8 0 / 0000 ). The results of a comparative analysis of dengue incidence and the main factors influencing it in the adjacent, the incidences of dengue fever of which are significantly different from each other, are shown. The application of geoinformation systems for epidemiological analysis has been demonstrated. It has been established that the distribution of the population of Vietnam differs greatly between the administrative regions of the country, and the use of population density for epidemiological analysis and forecasting of the epidemiological situation of infectious diseases, including dengue fever, can lead to incorrect results. Conclusion: The epidemiological situation of dengue fever in Vietnam is characterized by high incidence rates, their wide ranges of spatial and temporal variability, and geographical heterogeneity. The use of GIS technologies is one of the promising approaches for epidemiological analysis and monitoring of dengue fever, as well as other infectious diseases.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.22625/2072-6732-2023-15-3-146-151
N. V. Matsiyeuskaya, E. O. Samoilovich, G. V. Semeyko, O. V. Gvozdelyuk, A. S. Yushkevich
A description of a laboratory confirmed clinical case of generalized Varicella Zoster infection in a patient with lymphogranulomatosis after bone marrow transplantation is presented. Detection of the Varicella Zoster virus in biological material was carried out by real-time PCR using the RealBest DNA VZV test system manufactured by Vector-BEST, Russian Federation. Isolation of viral DNA from biological material was performed using the ArtRNA MiniSpin kit (ArtBioTech, Belarus) or QIAamp DNA mini kit (QIAGEN, Germany). The disease had an atypically severe course with a multiorgan lesion, represented not only by lesions of the skin and mucous membranes, but also by the development of encephalitis, myocarditis, and pneumonia. The disease was characterized by an acute onset, with a pronounced intoxication syndrome, signs of pancreatitis with the appearance of a widespread vesicular rash on the trunk and extremities, prone to fusion, located, including on the scalp, on the feet and palms. The disease was complicated by a secondary bacterial infection, in connection with which the patient received both antiviral treatment and broad-spectrum antibiotic therapy. The virus was assigned to clade 3 (or E2 genotype according to the old classification), the same genotype as the viruses circulating in Minsk. This case is the first described case of generalized VZV infection in the Republic of Belarus, confirmed by laboratory using molecular genetic methods.
描述了一个实验室证实的临床病例的广泛性水痘带状疱疹感染的病人淋巴肉芽肿后骨髓移植提出。采用俄罗斯Vector-BEST公司生产的RealBest DNA VZV检测系统对生物材料中的水痘带状疱疹病毒进行实时PCR检测。使用ArtRNA MiniSpin试剂盒(白俄罗斯ArtBioTech公司)或QIAamp DNA mini试剂盒(德国QIAGEN公司)从生物材料中分离病毒DNA。该病病程严重，伴有多器官病变，不仅表现为皮肤和粘膜病变，还表现为脑炎、心肌炎和肺炎。该疾病的特点是急性发作，伴有明显的中毒综合征，胰腺炎的体征，躯干和四肢出现广泛的水疱疹，容易融合，包括头皮、脚和手掌。该疾病并发继发性细菌感染，患者接受了抗病毒治疗和广谱抗生素治疗。该病毒属于进化支3(或根据旧分类为E2基因型)，与明斯克流行的病毒的基因型相同。该病例是白俄罗斯共和国第一例描述的广泛性VZV感染病例，经实验室使用分子遗传学方法确认。
{"title":"Generalized Varicella Zoster infection in a patient with lymphogranulomatosis after bone marrow transplantation: clinical and laboratory characteristics and virus genotyping","authors":"N. V. Matsiyeuskaya, E. O. Samoilovich, G. V. Semeyko, O. V. Gvozdelyuk, A. S. Yushkevich","doi":"10.22625/2072-6732-2023-15-3-146-151","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-3-146-151","url":null,"abstract":"A description of a laboratory confirmed clinical case of generalized Varicella Zoster infection in a patient with lymphogranulomatosis after bone marrow transplantation is presented. Detection of the Varicella Zoster virus in biological material was carried out by real-time PCR using the RealBest DNA VZV test system manufactured by Vector-BEST, Russian Federation. Isolation of viral DNA from biological material was performed using the ArtRNA MiniSpin kit (ArtBioTech, Belarus) or QIAamp DNA mini kit (QIAGEN, Germany). The disease had an atypically severe course with a multiorgan lesion, represented not only by lesions of the skin and mucous membranes, but also by the development of encephalitis, myocarditis, and pneumonia. The disease was characterized by an acute onset, with a pronounced intoxication syndrome, signs of pancreatitis with the appearance of a widespread vesicular rash on the trunk and extremities, prone to fusion, located, including on the scalp, on the feet and palms. The disease was complicated by a secondary bacterial infection, in connection with which the patient received both antiviral treatment and broad-spectrum antibiotic therapy. The virus was assigned to clade 3 (or E2 genotype according to the old classification), the same genotype as the viruses circulating in Minsk. This case is the first described case of generalized VZV infection in the Republic of Belarus, confirmed by laboratory using molecular genetic methods.","PeriodicalId":52123,"journal":{"name":"Jurnal Infektologii","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136057541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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