Pub Date : 2024-09-01DOI: 10.1016/j.coemr.2024.100543
Bacteria–host communication plays a crucial role in symbiosis and pathogenesis. Investigations of pathogenic bacterial responses to host neurotransmitters, including catecholamines, have been the subject of several studies. Both Epinephrine (Epi) and Norepinephrine (NE) catecholamines can modulate bacterial physiology, affecting growth, motility, biofilm formation, virulence, and interactions with eukaryotic cells. This has been widely described in Gram-negative bacteria and mostly for pathogens (i.e. Escherichia coli, Campylobacter jejuni, Salmonella enterica, and Vibrio cholerae). In this review, we focused on whole and targeted bacterial gene expression that have been modulated upon exposure to Epi and NE catecholamines. A wide range of these genes were involved in various physiological aspects (i.e. general metabolism, stress responses, uptake/transport, motility, biofilm, and virulence).
细菌与宿主的交流在共生和致病过程中起着至关重要的作用。病原细菌对宿主神经递质(包括儿茶酚胺)的反应是多项研究的主题。肾上腺素(Epi)和去甲肾上腺素(NE)儿茶酚胺都能调节细菌的生理机能,影响其生长、运动、生物膜形成、毒力以及与真核细胞的相互作用。这在革兰氏阴性细菌中得到了广泛的描述,并且主要针对病原体(即大肠杆菌、空肠弯曲杆菌、肠炎沙门氏菌和霍乱弧菌)。在这篇综述中,我们重点讨论了暴露于 Epi 和 NE 儿茶酚胺后受到调控的细菌全基因和靶基因表达。这些基因广泛涉及各种生理方面(即一般新陈代谢、应激反应、吸收/转运、运动、生物膜和毒力)。
{"title":"Bacterial gene expression in response to catecholamine stress hormones","authors":"","doi":"10.1016/j.coemr.2024.100543","DOIUrl":"10.1016/j.coemr.2024.100543","url":null,"abstract":"<div><p>Bacteria–host communication plays a crucial role in symbiosis and pathogenesis. Investigations of pathogenic bacterial responses to host neurotransmitters, including catecholamines, have been the subject of several studies. Both Epinephrine (Epi) and Norepinephrine (NE) catecholamines can modulate bacterial physiology, affecting growth, motility, biofilm formation, virulence, and interactions with eukaryotic cells. This has been widely described in Gram-negative bacteria and mostly for pathogens (<em>i.e</em>. <em>Escherichia coli</em>, <em>Campylobacter jejuni</em>, <em>Salmonella enterica,</em> and <em>Vibrio cholerae</em>). In this review, we focused on whole and targeted bacterial gene expression that have been modulated upon exposure to Epi and NE catecholamines. A wide range of these genes were involved in various physiological aspects (<em>i.e</em>. general metabolism, stress responses, uptake/transport, motility, biofilm, and virulence).</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/S2451-9650(24)00049-8
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00049-8","DOIUrl":"10.1016/S2451-9650(24)00049-8","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000498/pdfft?md5=2c19a62866a91cc227023f75c0207427&pid=1-s2.0-S2451965024000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1016/j.coemr.2024.100545
Cutaneous microorganisms are growing in a microenvironment where skin hormones and neurohormones are present in abundance. These molecules are markers of the host physiology, and microorganisms have developed strategies for detecting host factors that can represent a threat for their survival. Until now, our knowledge of these mechanisms is limited to bacteria, although the skin microbiota also includes an abundance of yeasts, fungi, viruses, and even archaea. Several human hormones and neurotransmitters, including substance P, calcitonin gene-related peptides, natriuretic peptides, catecholamines, and even estradiol have been studied in this context. This was leading to the identification of original proteins, such as the thermo-unstable ribosomal elongation factor, the chaperone DnaK, or the enzyme AmiC, which have been developed by bacteria and have dual functions, in the cytoplasm where they were originally identified and in the bacterial membrane where they act as sensors for host factors. These sensors, designed as moonlighting proteins for their dual functions, are submitted to structural reorganizations and probably post-translational modifications. The occurrence of epigenetic mechanisms in the regulation of moonlighting proteins activity is a source of major complications since similar processes are activated during bacteria adaptation to the host physiology and even storage. Cutaneous bacterial endocrinology is a wide and complex emerging scientific field that requires a deep knowledge of both human and microbial physiology and careful experimental procedures.
皮肤微生物是在皮肤激素和神经激素大量存在的微环境中生长的。这些分子是宿主生理机能的标记,微生物已经开发出了检测宿主因素的策略,这些因素可能对它们的生存构成威胁。到目前为止,我们对这些机制的了解仅限于细菌,尽管皮肤微生物群还包括大量的酵母菌、真菌、病毒甚至古细菌。在这方面,我们已经研究了几种人体激素和神经递质,包括 P 物质、降钙素基因相关肽、利尿肽、儿茶酚胺,甚至雌二醇。研究还发现了一些新的蛋白质,如热不稳定性核糖体伸长因子、伴侣蛋白 DnaK 或酶 AmiC,这些蛋白质是由细菌开发的,具有双重功能:在细胞质中,它们是最初被发现的;在细菌膜上,它们是宿主因子的传感器。这些传感器被设计成具有双重功能的兼职蛋白,它们的结构会发生重组,很可能会发生翻译后修饰。表观遗传机制对月光蛋白活性的调控是一个重大复杂问题的根源,因为在细菌适应宿主生理甚至贮存过程中,类似的过程也会被激活。皮肤细菌内分泌学是一个广泛而复杂的新兴科学领域,需要对人类和微生物生理学有深入的了解,并需要谨慎的实验程序。
{"title":"Interaction of skin-born mediators with the cutaneous microbiota and beyond","authors":"","doi":"10.1016/j.coemr.2024.100545","DOIUrl":"10.1016/j.coemr.2024.100545","url":null,"abstract":"<div><p>Cutaneous microorganisms are growing in a microenvironment where skin hormones and neurohormones are present in abundance. These molecules are markers of the host physiology, and microorganisms have developed strategies for detecting host factors that can represent a threat for their survival. Until now, our knowledge of these mechanisms is limited to bacteria, although the skin microbiota also includes an abundance of yeasts, fungi, viruses, and even archaea. Several human hormones and neurotransmitters, including substance P, calcitonin gene-related peptides, natriuretic peptides, catecholamines, and even estradiol have been studied in this context. This was leading to the identification of original proteins, such as the thermo-unstable ribosomal elongation factor, the chaperone DnaK, or the enzyme AmiC, which have been developed by bacteria and have dual functions, in the cytoplasm where they were originally identified and in the bacterial membrane where they act as sensors for host factors. These sensors, designed as moonlighting proteins for their dual functions, are submitted to structural reorganizations and probably post-translational modifications. The occurrence of epigenetic mechanisms in the regulation of moonlighting proteins activity is a source of major complications since similar processes are activated during bacteria adaptation to the host physiology and even storage. Cutaneous bacterial endocrinology is a wide and complex emerging scientific field that requires a deep knowledge of both human and microbial physiology and careful experimental procedures.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1016/j.coemr.2024.100542
Obesity is a significant global burden for individuals and healthcare systems with its array of associated chronic cardiometabolic diseases. While lifestyle modifications such as dietary interventions and increased physical activity are effective in weight management, recent investigations highlight the critical role of timing these interventions in accordance with our body's circadian clock. Over the past decade, multiple studies and meta analyses have investigated how the timing of exercise training influences white adipose tissue (WAT) biology, fat mass loss, and obesity, but physical activity guidelines have not yet adopted a recommendation for exercise timing due to conflicting conclusions. This review aims to summarize the latest findings in this field and touches upon contributing factors such as sex disparities and nutrition timing.
{"title":"Timing of physical activity in the pursuit of fat mass loss and weight maintenance","authors":"","doi":"10.1016/j.coemr.2024.100542","DOIUrl":"10.1016/j.coemr.2024.100542","url":null,"abstract":"<div><p>Obesity is a significant global burden for individuals and healthcare systems with its array of associated chronic cardiometabolic diseases. While lifestyle modifications such as dietary interventions and increased physical activity are effective in weight management, recent investigations highlight the critical role of timing these interventions in accordance with our body's circadian clock. Over the past decade, multiple studies and meta analyses have investigated how the timing of exercise training influences white adipose tissue (WAT) biology, fat mass loss, and obesity, but physical activity guidelines have not yet adopted a recommendation for exercise timing due to conflicting conclusions. This review aims to summarize the latest findings in this field and touches upon contributing factors such as sex disparities and nutrition timing.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000401/pdfft?md5=c2a01dab6aa7129a7cbd8ed5b61bfefa&pid=1-s2.0-S2451965024000401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.1016/j.coemr.2024.100540
The adaptation to changing environmental cues represents a key prerequisite for the survival of an organism. Mammals, including humans, have evolved intricate endocrine signals to convey information about the nutritional status to individual organs, cells, and eventually the cell nucleus, to trigger appropriate molecular-metabolic responses. To this end, mounting a proper fasting response is determined by not only intra-organ adaptations but also inter-tissue crosstalk mechanisms that orchestrate whole-body energy homeostasis under nutrient-deprived conditions. Here, we shortly summarize recent advances in our current understanding of the key processes driving the adaptive response to fasting with a focus on the crosstalk between the adipose tissue and liver ketogenesis.
{"title":"Fasting-regulated mechanisms in inter-organ crosstalk","authors":"","doi":"10.1016/j.coemr.2024.100540","DOIUrl":"10.1016/j.coemr.2024.100540","url":null,"abstract":"<div><p>The adaptation to changing environmental cues represents a key prerequisite for the survival of an organism. Mammals, including humans, have evolved intricate endocrine signals to convey information about the nutritional status to individual organs, cells, and eventually the cell nucleus, to trigger appropriate molecular-metabolic responses. To this end, mounting a proper fasting response is determined by not only intra-organ adaptations but also inter-tissue crosstalk mechanisms that orchestrate whole-body energy homeostasis under nutrient-deprived conditions. Here, we shortly summarize recent advances in our current understanding of the key processes driving the adaptive response to fasting with a focus on the crosstalk between the adipose tissue and liver ketogenesis.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000383/pdfft?md5=bc170d1253de810829c6e33e4643659b&pid=1-s2.0-S2451965024000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1016/j.coemr.2024.100539
Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of inflammation, an actively regulated process. New evidence suggests that such lipids (e.g. lipoxins) could resolve adipose tissue inflammation and, thus, subvert obesity-related diseases. A key feature of pro-resolving lipids is their ability to promote an M2-like macrophage phenotype and enhance efferocytosis while avoiding adverse side-effects typically associated with anti-inflammatory drugs, such as increased sensitivity to infections. This brief review discusses the therapeutic potential of pro-resolving lipid mediators in mitigating systemic disease fueled by adipose tissue inflammation in both experimental and human disease models.
{"title":"Attenuation of adipose tissue inflammation by pro-resolving lipid mediators","authors":"","doi":"10.1016/j.coemr.2024.100539","DOIUrl":"10.1016/j.coemr.2024.100539","url":null,"abstract":"<div><p>Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of inflammation, an actively regulated process. New evidence suggests that such lipids (e.g. lipoxins) could resolve adipose tissue inflammation and, thus, subvert obesity-related diseases. A key feature of pro-resolving lipids is their ability to promote an M2-like macrophage phenotype and enhance efferocytosis while avoiding adverse side-effects typically associated with anti-inflammatory drugs, such as increased sensitivity to infections. This brief review discusses the therapeutic potential of pro-resolving lipid mediators in mitigating systemic disease fueled by adipose tissue inflammation in both experimental and human disease models.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000371/pdfft?md5=4ae9fe6975231130f1cb7d542ac2f363&pid=1-s2.0-S2451965024000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1016/j.coemr.2024.100541
Bilateral adrenal cortex hyperplasias can present in various forms and are divided as either macronodular or micronodular. This review presents the recent identifications of the genetic alterations responsible for the various forms of cortisol-secreting adrenal hyperplasias. These include the tumor suppressor genes ARMC5 in bilateral primary macronodular adrenal hyperplasia (PBMAH) and KDM1A in GIP-dependent PBMAH with Cushing’s syndrome. Other genetic alterations are found in PBMAH associated with rare syndromic forms and various cAMP/PKA pathway gene mutations are involved in both macronodular and micronodular adrenal hyperplasias. We present as well certain clinical recommendations for each genetic etiology, including that ARMC5 or KDM1A genetic testing should be offered to all patients with PBMAH, depending on the Cushing syndrome’s GIP-dependence or not.
{"title":"Genetics of cortisol-secreting bilateral macro- and micronodular adrenal hyperplasias","authors":"","doi":"10.1016/j.coemr.2024.100541","DOIUrl":"10.1016/j.coemr.2024.100541","url":null,"abstract":"<div><p>Bilateral adrenal cortex hyperplasias can present in various forms and are divided as either macronodular or micronodular. This review presents the recent identifications of the genetic alterations responsible for the various forms of cortisol-secreting adrenal hyperplasias. These include the tumor suppressor genes <em>ARMC5</em> in bilateral primary macronodular adrenal hyperplasia (PBMAH) and <em>KDM1A</em> in GIP-dependent PBMAH with Cushing’s syndrome. Other genetic alterations are found in PBMAH associated with rare syndromic forms and various cAMP/PKA pathway gene mutations are involved in both macronodular and micronodular adrenal hyperplasias. We present as well certain clinical recommendations for each genetic etiology, including that <em>ARMC5</em> or <em>KDM1A</em> genetic testing should be offered to all patients with PBMAH, depending on the Cushing syndrome’s GIP-dependence or not.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000395/pdfft?md5=75ff7d13bafa41b57854769888e8b971&pid=1-s2.0-S2451965024000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-29DOI: 10.1016/j.coemr.2024.100538
{"title":"Editorial overview: Genetics of endocrine tumors","authors":"","doi":"10.1016/j.coemr.2024.100538","DOIUrl":"10.1016/j.coemr.2024.100538","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.coemr.2024.100537
Human organism is tightly interconnected with its microbiota on physiological and signaling levels. Microbial endocrinology as an interdisciplinary area of studying host–microbiota interactions can focus on either player: how the microbiota affects the host via synthesis of host-targeted humoral factors and how the host-derived molecules regulate the microbial community homeostasis. The present mini-review presents the authors' perspective on the impact of human hormones on the microbiota. It discusses known effects, but especially outlines existing complications in this research area, and proposes directions for future investigation.
{"title":"How human hormones regulate human microbiota: Where are we in the middle of this terra incognita?","authors":"","doi":"10.1016/j.coemr.2024.100537","DOIUrl":"10.1016/j.coemr.2024.100537","url":null,"abstract":"<div><p>Human organism is tightly interconnected with its microbiota on physiological and signaling levels. Microbial endocrinology as an interdisciplinary area of studying host–microbiota interactions can focus on either player: how the microbiota affects the host via synthesis of host-targeted humoral factors and how the host-derived molecules regulate the microbial community homeostasis. The present mini-review presents the authors' perspective on the impact of human hormones on the microbiota. It discusses known effects, but especially outlines existing complications in this research area, and proposes directions for future investigation.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin-producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions, and environmental factors create a dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM and described the shifts in oral microbial composition and oral immune response.
{"title":"Type 1 diabetes mellitus and host–bacterial interactions in the oral cavity","authors":"Ulvi Kahraman Gürsoy , Neslihan Yilmaz , Dogukan Yilmaz , Sanni Grönroos , Mervi Gürsoy","doi":"10.1016/j.coemr.2024.100536","DOIUrl":"10.1016/j.coemr.2024.100536","url":null,"abstract":"<div><p>Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin-producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions, and environmental factors create a dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM and described the shifts in oral microbial composition and oral immune response.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000346/pdfft?md5=a0dd3a5069cc0af9d23b75036a52e4d5&pid=1-s2.0-S2451965024000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}