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Smartphone Apps for Diabetes Medication Adherence: Systematic Review. 糖尿病药物依从性的智能手机应用程序:系统评价。
Q2 Medicine Pub Date : 2022-06-21 DOI: 10.2196/33264
Sheikh Mohammed Shariful Islam, Vinaytosh Mishra, Muhammad Umer Siddiqui, Jeban Chandir Moses, Sasan Adibi, Lemai Nguyen, Nilmini Wickramasinghe

Background: Diabetes is one of the leading noncommunicable chronic diseases globally. In people with diabetes, blood glucose levels need to be monitored regularly and managed adequately through healthy lifestyles and medications. However, various factors contribute to poor medication adherence. Smartphone apps can improve medication adherence in people with diabetes, but it is not clear which app features are most beneficial.

Objective: This study aims to systematically review and evaluate high-quality apps for diabetes medication adherence, which are freely available to the public in Android and Apple app stores and present the technical features of the apps.

Methods: We systematically searched Apple App Store and Google Play for apps that assist in diabetes medication adherence, using predefined selection criteria. We assessed apps using the Mobile App Rating Scale (MARS) and calculated the mean app-specific score (MASS) by taking the average of app-specific scores on 6 dimensions, namely, awareness, knowledge, attitudes, intention to change, help-seeking, and behavior change rated on a 5-point scale (1=strongly disagree and 5=strongly agree). We used the mean of the app's performance on these 6 dimensions to calculate the MASS. Apps that achieved a total MASS mean quality score greater than 4 out of 5 were considered to be of high quality in our study. We formulated a task-technology fit matrix to evaluate the apps for diabetes medication adherence.

Results: We identified 8 high-quality apps (MASS score≥4) and presented the findings under 3 main categories: characteristics of the included apps, app features, and diabetes medication adherence. Our framework to evaluate smartphone apps in promoting diabetes medication adherence considered physiological factors influencing diabetes and app features. On evaluation, we observed that 25% of the apps promoted high adherence and another 25% of the apps promoted moderate adherence. Finally, we found that 50% of the apps provided low adherence to diabetes medication.

Conclusions: Our findings show that almost half of the high-quality apps publicly available for free did not achieve high to moderate medication adherence. Our framework could have positive implications for the future design and development of apps for patients with diabetes. Additionally, apps need to be evaluated using a standardized framework, and only those promoting higher medication adherence should be prescribed for better health outcomes.

背景:糖尿病是全球主要的非传染性慢性病之一。糖尿病患者需要定期监测血糖水平,并通过健康的生活方式和药物进行适当管理。然而,各种因素导致药物依从性差。智能手机应用程序可以提高糖尿病患者的服药依从性,但目前尚不清楚哪种应用程序功能最有益。目的:本研究旨在对Android和Apple应用商店中免费向公众开放的优质糖尿病药物依从性应用进行系统回顾和评价,并展示应用的技术特点。方法:我们使用预定义的选择标准,系统地在Apple App Store和Google Play中搜索有助于糖尿病药物依从性的应用程序。我们使用移动应用评级量表(MARS)对应用进行评估,并通过在6个维度(即意识、知识、态度、改变意图、寻求帮助和行为改变)上取平均分数来计算应用特定得分(MASS)(1=非常不同意,5=非常同意)。我们使用应用程序在这6个维度上的表现的平均值来计算质量。在我们的研究中,达到总MASS平均质量分数大于4分(满分5分)的应用程序被认为是高质量的。我们制定了一个任务-技术拟合矩阵来评估糖尿病药物依从性应用程序。结果:我们确定了8个高质量应用程序(MASS评分≥4),并将研究结果分为3个主要类别:纳入应用程序的特征、应用程序功能和糖尿病药物依从性。我们评估智能手机应用程序促进糖尿病药物依从性的框架考虑了影响糖尿病的生理因素和应用程序功能。在评估中,我们观察到25%的应用程序促进了高依从性,另外25%的应用程序促进了中等依从性。最后,我们发现50%的应用程序对糖尿病药物的依从性很低。结论:我们的研究结果表明,几乎一半的高质量免费公开应用程序没有达到高到中等程度的药物依从性。我们的框架可能会对糖尿病患者应用程序的未来设计和开发产生积极的影响。此外,应用程序需要使用标准化框架进行评估,只有那些促进更高药物依从性的应用程序才应该开出更好的健康结果处方。
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引用次数: 7
Informing a Randomized Control Trial in Rural Populations: Adaptation of a Diabetes Self-Management Education and Support Intervention 在农村人群中进行随机对照试验:糖尿病自我管理教育和支持干预的适应性
Q2 Medicine Pub Date : 2022-06-10 DOI: 10.2196/35664
Tamara K. Oser, Linda Zittleman, K. Curcija, Bethany M. Kwan, Shawnecca Burke, Sindy Gonzalez, Kelsey Huss, Marilee Johnson, Norah Sanchez, J. Neuberger, E. Iacob, Juliana Simonetti, Michelle L. Litchman
Background Over 34 million people in the United States have diabetes, with 1.5 million diagnosed every year. Diabetes self-management education and support (DSMES) is a crucial component of treatment to delay or prevent complications. Rural communities face many unique challenges in accessing DSMES, including geographic barriers and availability of DSMES programs that are culturally adapted to rural context. Objective Boot Camp Translation (BCT) is an established approach to community-based participatory research used to translate complex clinical and scientific information into concepts, messages, and materials that are understandable, meaningful, and relevant to community members and patients. This study aimed to utilize BCT to adapt an existing DSMES program for delivery in rural primary care for English- and Spanish-speaking people with diabetes. Methods The High Plains Research Network (HPRN) Community Advisory Council (C.A.C.) partnered with researchers at the University of Colorado and University of Utah to use BCT to aid in translating medical jargon and materials from an existing DSMES program, called “Diabetes One Day (D1D).” BCT consisted of 10 virtual meetings over a 6-month period among the C.A.C., which included 15 diverse community stakeholders. Both English-speaking and bilingual Spanish-English–speaking C.A.C. members were recruited to reflect the diversity of the rural communities in which the adapted program would be delivered. Results The BCT process guided adaptations to D1D for use in rural settings (R-D1D). R-D1D adaptations reflect both content and delivery to assure that the intervention is appropriate and likely to be accepted by rural English- and Spanish-speaking people with diabetes. Additionally, BCT informed the design of recruitment and program materials and identification of recruitment venues. During the BCT process, the importance of tailoring materials to reflect culture differences in English- and Spanish-speaking patients was identified. Conclusions BCT was an effective strategy for academic researchers to partner with rural community members to adapt an existing DSMES intervention for delivery in rural areas to both English- and Spanish-speaking patients with diabetes. Through BCT, adaptations to recruitment materials and methods, program content and delivery, and supplemental materials were developed. The need to culturally adapt Spanish materials with input from stakeholders rather than simply translate materials into Spanish was highlighted. The importance of increasing awareness of the connection between diabetes and depression or diabetes distress, adaptations to include local foods, and the importance of the relationship between people with diabetes and their primary care practices were identified.
背景美国有3400多万人患有糖尿病,每年有150万人被诊断为糖尿病。糖尿病自我管理教育和支持(DSMES)是延迟或预防并发症治疗的重要组成部分。农村社区在获得DSMES方面面临许多独特的挑战,包括地理障碍和适合农村文化的DSMES计划的可用性。目标训练营翻译(BCT)是一种基于社区的参与性研究的既定方法,用于将复杂的临床和科学信息转化为可理解、有意义且与社区成员和患者相关的概念、信息和材料。本研究旨在利用BCT调整现有的DSMES计划,为英语和西班牙语糖尿病患者提供农村初级保健。方法高平原研究网络(HPRN)社区咨询委员会(C.A.C.)与科罗拉多大学和犹他大学的研究人员合作,使用BCT帮助翻译现有DSMES项目中的医学术语和材料,该项目名为“糖尿病一天(D1D)”。,其中包括15个不同的社区利益相关者。招募了英语和西班牙语-英语双语的C.A.C.成员,以反映改编后的项目将在其中实施的农村社区的多样性。结果BCT过程指导了在农村环境中使用D1D(R-D1D)。R-D1D的调整反映了内容和交付,以确保干预措施是适当的,并可能被农村英语和西班牙语糖尿病患者接受。此外,BCT还为招募和项目材料的设计以及招募地点的确定提供了信息。在BCT过程中,确定了剪裁材料以反映英语和西班牙语患者的文化差异的重要性。结论BCT是学术研究人员与农村社区成员合作的有效策略,可以将现有的DSMES干预措施应用于农村地区的英语和西班牙语糖尿病患者。通过BCT,对招募材料和方法、项目内容和交付以及补充材料进行了调整。强调需要根据利益攸关方的意见对西班牙语材料进行文化改编,而不是简单地将材料翻译成西班牙语。确定了提高对糖尿病与抑郁症或糖尿病困扰之间联系的认识的重要性、适应当地食物的重要性,以及糖尿病患者与其初级保健实践之间关系的重要性。
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引用次数: 0
Community Health Worker-Led mHealth-Enabled Diabetes Self-management Education and Support Intervention in Rural Latino Adults: Single-Arm Feasibility Trial. 农村拉丁裔成人社区卫生工作者领导的移动医疗糖尿病自我管理教育和支持干预:单组可行性试验
Q2 Medicine Pub Date : 2022-05-30 DOI: 10.2196/37534
Shiyu Li, Zenong Yin, Janna Lesser, Chengdong Li, Byeong Yeob Choi, Deborah Parra-Medina, Belinda Flores, Brittany Dennis, Jing Wang

Background: Latinos living in rural South Texas have a higher prevalence of diabetes, but their access to diabetes self-management education and support (DSMES) is limited.

Objective: We aimed to test the feasibility of a community health worker-led, mobile health (mHealth)-based DSMES intervention to reduce disparities in accessing DSMES in underserved rural Latino residents in South Texas.

Methods: This 12-week, single-arm, pre-post trial was delivered by trained community health workers to 15 adults with type 2 diabetes. The intervention consisted of digital diabetes education, self-monitoring, a cloud-based connected platform, and community health worker support. Feasibility was evaluated as retention, actual intervention use, program satisfaction, and barriers to implementation. We also explored the intervention's effect on weight loss and hemoglobin A1c (HbA1c).

Results: All 15 participants were Latino (mean age 61.87 years, SD 10.67; 9/15 female, 60%). The retention rate at posttest was 14 of 15 (93%). On average, the participants completed 37 of 42 (88%) digital diabetes education lessons with 8 participants completing all lessons. Participants spent 81/91 days (89%) step tracking, 71/91 days (78%) food logging, 43/91 days (47%) blood glucose self-monitoring, and 74/91 days (81%) weight self-monitoring. The level of program satisfaction was high. On average, participants lost 3.5 (SD 3.2) kg of body weight (P=.001), while HbA1c level remained unchanged from baseline (6.91%, SD 1.28%) to posttest (7.04%, SD 1.66%; P=.668).

Conclusions: A community health worker-led mHealth-based intervention was feasible and acceptable to improve access to DSMES services for Latino adults living in rural communities. Future randomized controlled trials are needed to test intervention efficacy on weight loss and glycemic control.

背景:生活在德克萨斯州南部农村的拉美裔糖尿病患病率较高,但他们获得糖尿病自我管理教育和支持(DSMES)的机会有限。目的:我们旨在测试社区卫生工作者主导的、基于移动医疗(mHealth)的DSMES干预的可行性,以减少南德克萨斯州服务不足的农村拉丁裔居民在获得DSMES方面的差异。方法:这项为期12周、单臂、前后试验由训练有素的社区卫生工作者对15名2型糖尿病成年人进行。干预措施包括数字化糖尿病教育、自我监测、基于云的连接平台和社区卫生工作者支持。可行性评估为保留、实际干预使用、计划满意度和实施障碍。我们还探讨了干预对减肥和血红蛋白A1c (HbA1c)的影响。结果:所有15名参与者均为拉丁裔(平均年龄61.87岁,SD 10.67;9/15女性,占60%)。后测保留率为14 / 15(93%)。平均而言,参与者完成了42个数字糖尿病教育课程中的37个(88%),其中8个参与者完成了所有课程。参与者进行了81/91天(89%)的步数跟踪,71/91天(78%)的食物记录,43/91天(47%)的血糖自我监测,74/91天(81%)的体重自我监测。项目满意度很高。平均而言,参与者体重减轻3.5 kg (SD 3.2) (P=.001),而HbA1c水平从基线(6.91%,SD 1.28%)到测试后(7.04%,SD 1.66%;P = .668)。结论:社区卫生工作者领导的基于移动健康的干预措施是可行和可接受的,可以改善生活在农村社区的拉丁裔成年人获得DSMES服务的机会。需要未来的随机对照试验来检验干预对减肥和血糖控制的效果。
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引用次数: 4
Implementing the Digital Diabetes Questionnaire as a Clinical Tool in Routine Diabetes Care: Focus Group Discussions With Patients and Health Care Professionals 在常规糖尿病护理中实施数字糖尿病问卷作为临床工具:与患者和卫生保健专业人员的焦点小组讨论
Q2 Medicine Pub Date : 2022-05-25 DOI: 10.2196/34561
Maria Svedbo Engström, U. Johansson, J. Leksell, Ebba Linder, K. Eeg-Olofsson
Background The Diabetes Questionnaire is a digital patient-reported outcome and experience measure for adults living with diabetes. The Diabetes Questionnaire is intended for use in routine clinical visits in diabetes care and to enable patient perspectives to be integrated into the Swedish National Diabetes Register. The Diabetes Questionnaire was developed on the basis of patients’ perspectives, and evidence for its measurement qualities has been demonstrated. Patients receive an invitation to complete the questionnaire before clinical visits, and the patient and health care professional (HCP) can discuss the findings, which are instantly displayed during the visit. Implementation processes for new tools in routine care need to be studied to understand the influence of contextual factors, the support needed, and how patients and HCPs experience clinical use. Objective The aim of this study was to describe patients’ and HCPs’ experiences of initiating the use of the digital Diabetes Questionnaire as a clinical tool in routine diabetes care, supported by a structured implementation strategy involving initial education, local facilitators, and regular follow-ups. Methods In this qualitative study, semistructured focus group discussions were conducted 12 months after the use of the Diabetes Questionnaire was initiated. Participants were diabetes specialist nurses and physicians (20 participants in 4 groups) at hospital-based outpatient clinics or primary health care clinics and adults with type 1 or type 2 diabetes (15 participants in 4 groups). The audiotaped transcripts were analyzed using inductive qualitative content analysis. Results The results revealed 2 main categories that integrated patients’ and HCPs’ experiences, which together formed an overarching theme: While implementation demands new approaches, the Diabetes Questionnaire provides a broader perspective. The first main category (The Diabetes Questionnaire supports person-centered clinical visits) comprised comments expressing that the digital Diabetes Questionnaire can initiate and encourage reflection in preparation for clinical visits, bring important topics to light during clinical visits, and broaden the scope of discussion by providing additional information. The second main category (The process of initiating the implementation of the Diabetes Questionnaire) comprised comments that described differences in engagement among HCPs and their managers, challenges of establishing new routines, experiences of support during implementation, thoughts about the Diabetes Questionnaire, need to change local administrative routines, and opportunities and concerns for continued use. Conclusions The Diabetes Questionnaire can broaden the scope of health data in routine diabetes care. While implementation demands new approaches, patients and HCPs saw potential positive impacts of using the questionnaire at both the individual and group levels. Our results can inform further development of imp
背景糖尿病问卷是一项针对患有糖尿病的成年人的数字患者报告的结果和经验测量。糖尿病问卷旨在用于糖尿病护理的常规临床访问,并使患者的观点能够纳入瑞典国家糖尿病登记册。糖尿病问卷是在患者观点的基础上开发的,其测量质量的证据已经得到证明。患者在临床就诊前收到填写问卷的邀请,患者和医疗保健专业人员(HCP)可以讨论调查结果,并在就诊期间立即显示。需要研究常规护理中新工具的实施过程,以了解背景因素的影响、所需的支持以及患者和HCP如何体验临床使用。目的本研究的目的是描述患者和HCP在启动使用数字糖尿病问卷作为常规糖尿病护理的临床工具方面的经验,并辅以结构化的实施策略,包括初始教育、当地辅导员和定期随访。方法在这项定性研究中,在开始使用糖尿病问卷12个月后进行半结构的焦点小组讨论。参与者是医院门诊或初级保健诊所的糖尿病专科护士和医生(4组20名参与者),以及患有1型或2型糖尿病的成年人(4组15名参与者)。录音记录采用归纳定性内容分析法进行分析。结果结果显示,2个主要类别整合了患者和HCP的经验,共同形成了一个总体主题:虽然实施需要新的方法,但糖尿病问卷提供了更广泛的视角。第一个主要类别(糖尿病问卷支持以人为中心的临床访问)包括评论,表示数字糖尿病问卷可以在临床访问准备过程中发起和鼓励反思,在临床访问期间揭示重要主题,并通过提供额外信息扩大讨论范围。第二个主要类别(启动实施糖尿病问卷的过程)包括描述HCP及其管理人员之间参与度差异、建立新程序的挑战、实施过程中的支持经验、对糖尿病问卷的思考、改变当地行政程序的必要性的评论,以及继续使用的机会和关切。结论糖尿病调查表可拓宽糖尿病常规护理的健康数据范围。虽然实施需要新的方法,但患者和HCP看到了在个人和团体层面使用问卷的潜在积极影响。我们的研究结果可以为进一步制定实施策略提供信息,以支持问卷的临床使用。
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引用次数: 1
Evaluation of Self-care Activities and Quality of Life in Patients With Type 2 Diabetes Treated With Metformin Using the 2D Matrix Code of Outer Drug Packages as Patient Identifier: the DePRO Proof-of-Concept Observational Study 使用外包装二维矩阵码作为患者标识符评价二甲双胍治疗的2型糖尿病患者的自我护理活动和生活质量:DePRO概念验证观察性研究
Q2 Medicine Pub Date : 2022-05-24 DOI: 10.2196/31832
C. Mueller, Isabel Schauerte, Stephan Martin, V. Irrgang
Background The use of digital technology to assess patients remotely can reduce clinical study costs. In the European Union, the 2D matrix code on prescription drug packaging serves as a unique identifier of a given package of medication, and thus, also of the patient receiving that medication. Scanning of the 2D matrix code may therefore allow remote patient authentication in clinical studies. Objective The aim of the DePRO study was to assess the feasibility of a fully digital data-capture workflow, the authentication of participants via drug packaging 2D matrix codes, in patients with type 2 diabetes mellitus (T2DM) who use metformin. The primary objective was to describe the self-care activities of these patients. Secondary objectives were to evaluate (1) the self-reported health status of these patients, (2) the association of self-care activities with demographics and disease characteristics, and (3) the usability of the my ePRO app. Methods DePRO was an observational, multicenter, cross-sectional, digital, and patient-driven study conducted in Germany from June to December 2020. Adult patients prescribed metformin were invited to participate via their pharmacist or a medication tracker app. Participants downloaded the my ePRO app onto their own mobile device, scanned the 2D matrix code on their metformin package for registration and authentication, and provided informed consent via an electronic form. They were then able to complete a study-specific questionnaire on demographics and clinical characteristics, the German version of the Summary of Diabetes Self-Care Activities measure (SDSCA-G), the Diabetes Treatment Satisfaction Questionnaire (DTSQ), and the EQ-5D-5L. The patients conducted the study without support from a health care professional. Statistical analyses were exploratory and descriptive. Results In total, 3219 patients were invited to participate. The proportion of patients giving consent was greater among those invited by pharmacists (19/217, 8.8%) than among those invited via the medication tracker app (13/3002, 0.4%). Of the 29 patients eligible for analysis, 28 (97%) completed all study questionnaires. Most of the patients (23/29, 79%) were aged <60 years, and 59% (17/29) were male. The patients spent a mean total of 3.5 (SD 1.3) days out of 7 days on self-care activities (SDSCA-G). Most patients (24/29, 83%) were satisfied to extremely satisfied with their current treatment (DTSQ). Events of perceived hyperglycemia or hypoglycemia were reported by 20 of 29 (69%) patients. The best possible health status (EQ-5D-5L) was reported by 18 of 28 (64%) patients. Age was positively correlated with time spent on general and specific diet (Spearman coefficient 0.390 and 0.434, respectively). Conclusions The DePRO study demonstrates the feasibility of fully digital authentication (via 2D matrix codes on drug packaging) and data capture in patients with T2DM. Personal invitations yielded higher recruitment rates than remote invitatio
使用数字技术对患者进行远程评估可以降低临床研究成本。在欧盟,处方药包装上的二维矩阵代码作为给定药物包装的唯一标识符,因此也作为接受该药物的患者的唯一标识符。因此,扫描二维矩阵代码可以在临床研究中实现远程患者认证。DePRO研究的目的是评估使用二甲双胍的2型糖尿病(T2DM)患者的全数字化数据捕获工作流程,即通过药物包装二维矩阵码对参与者进行认证的可行性。主要目的是描述这些患者的自我保健活动。次要目的是评估(1)这些患者自我报告的健康状况,(2)自我保健活动与人口统计学和疾病特征的关联,以及(3)my ePRO应用程序的可用性。方法DePRO是一项观察性、多中心、横断面、数字化、患者驱动的研究,于2020年6月至12月在德国进行。处方二甲双胍的成年患者被邀请通过他们的药剂师或药物跟踪应用程序参与。参与者将my ePRO应用程序下载到自己的移动设备上,扫描二甲双胍包装上的二维矩阵代码进行注册和认证,并通过电子表格提供知情同意。然后,他们能够完成一份关于人口统计学和临床特征的研究特定问卷,德文版糖尿病自我护理活动摘要测量(SDSCA-G),糖尿病治疗满意度问卷(DTSQ)和EQ-5D-5L。患者在没有医疗保健专业人员支持的情况下进行了这项研究。统计分析是探索性和描述性的。结果共邀请3219例患者参与。药师邀请的患者表示同意的比例(19/217,8.8%)大于通过药物追踪app邀请的患者(13/3002,0.4%)。在符合分析条件的29例患者中,28例(97%)完成了所有研究问卷。大多数患者(23/29,79%)年龄<60岁,59%(17/29)为男性。患者在自我护理活动(SDSCA-G)上的平均时间为3.5天(SD 1.3)。大多数患者(24/ 29,83 %)对当前治疗满意至极满意(DTSQ)。29例患者中有20例(69%)报告了可感知的高血糖或低血糖事件。28例(64%)患者中有18例报告了可能的最佳健康状况(EQ-5D-5L)。年龄与一般饮食和特殊饮食时间呈正相关(Spearman系数分别为0.390和0.434)。DePRO研究证明了T2DM患者全数字认证(通过药品包装上的二维矩阵码)和数据采集的可行性。个人邀请的招募率高于通过药物跟踪应用程序进行的远程邀请。29名患者中有28名完成了问卷调查,从而实现了较高的问卷完成率。试验注册ClinicalTrials.gov NCT04383041;https://clinicaltrials.gov/ct2/show/NCT04383041国际注册报告标识符(IRRID) RR2-10.2196/21727
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引用次数: 2
Accuracy of the Standard GlucoNavii Mentor in Blood Glucose Monitoring According to International Organization for Standardization 15197:2013 Criteria 根据国际标准化组织15197:2013标准GlucoNavii Mentor在血糖监测中的准确性
Q2 Medicine Pub Date : 2022-05-20 DOI: 10.2196/20774
Heeyoung Hwang, L. Leonardi, A. Nicolucci
This study was performed to assess the system accuracy of the blood glucose monitoring system SD GlucoNavii Mentor (SD Biosensor Inc, Korea). The study procedures were based on International Organization for Standardization 15197:2013, in that capillary blood samples from 100 participants’ fingertips were measured with three reagent system lots of the self-monitoring blood glucose system. Samples were collected for comparison measurements on a hexokinase-based glucose analyzer (Cobas Integra400 Plus, Roche Instrument Center, Switzerland). Glucose concentrations were distributed as required by International Organization for Standardization 15197. For each of the 100 evaluable samples, duplicate measurements were taken from three different reagent lots, for a total of 600 measurements. Overall, 98.3% (590/600) of individual measurement results (185/186, 99.5% for glucose values <100 mg/dl and 405/414, 97.8% for glucose values ≥100 mg/dl) were within ±15 mg/dl or ±15% of the corresponding comparison method results. All results (100%) fell into the consensus error grid zones A and B, indicating only clinically acceptable results. In conclusion, the blood glucose monitoring system SD GlucoNavii Mentor device fulfilled the system accuracy criteria of the International Organization for Standardization 15197, indicating measurement accuracy sufficient for diabetes therapy.
本研究旨在评估血糖监测系统SD GlucoNavii Mentor (SD Biosensor Inc .,韩国)的系统准确性。研究程序参照国际标准化组织15197:2013,采用自我监测血糖系统的三种试剂系统lots测量100名参与者指尖的毛细血管血液样本。收集样品,在基于己糖激酶的葡萄糖分析仪(Cobas Integra400 Plus,罗氏仪器中心,瑞士)上进行比较测量。葡萄糖浓度按国际标准化组织15197的要求分布。对于100个可评估样品中的每一个,从三个不同的试剂批次中进行重复测量,总共进行600次测量。总体而言,98.3%(590/600)的个体测量结果(185/186、99.5%的葡萄糖值<100 mg/dl和405/414、97.8%的葡萄糖值≥100 mg/dl)与相应的比较方法结果在±15 mg/dl或±15%以内。所有结果(100%)均落入共识误差网格区A和B,表明只有临床可接受的结果。综上所述,血糖监测系统SD GlucoNavii Mentor设备达到国际标准化组织15197的系统精度标准,测量精度足以满足糖尿病治疗的要求。
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引用次数: 0
Identifying Patients With Hypoglycemia Using Natural Language Processing: Systematic Literature Review. 用自然语言处理识别低血糖患者:系统文献综述。
Q2 Medicine Pub Date : 2022-05-16 DOI: 10.2196/34681
Yaguang Zheng, Victoria Vaughan Dickson, Saul Blecker, Jason M Ng, Brynne Campbell Rice, Gail D'Eramo Melkus, Liat Shenkar, Marie Claire R Mortejo, Stephen B Johnson

Background: Accurately identifying patients with hypoglycemia is key to preventing adverse events and mortality. Natural language processing (NLP), a form of artificial intelligence, uses computational algorithms to extract information from text data. NLP is a scalable, efficient, and quick method to extract hypoglycemia-related information when using electronic health record data sources from a large population.

Objective: The objective of this systematic review was to synthesize the literature on the application of NLP to extract hypoglycemia from electronic health record clinical notes.

Methods: Literature searches were conducted electronically in PubMed, Web of Science Core Collection, CINAHL (EBSCO), PsycINFO (Ovid), IEEE Xplore, Google Scholar, and ACL Anthology. Keywords included hypoglycemia, low blood glucose, NLP, and machine learning. Inclusion criteria included studies that applied NLP to identify hypoglycemia, reported the outcomes related to hypoglycemia, and were published in English as full papers.

Results: This review (n=8 studies) revealed heterogeneity of the reported results related to hypoglycemia. Of the 8 included studies, 4 (50%) reported that the prevalence rate of any level of hypoglycemia was 3.4% to 46.2%. The use of NLP to analyze clinical notes improved the capture of undocumented or missed hypoglycemic events using International Classification of Diseases, Ninth Revision (ICD-9), and International Classification of Diseases, Tenth Revision (ICD-10), and laboratory testing. The combination of NLP and ICD-9 or ICD-10 codes significantly increased the identification of hypoglycemic events compared with individual methods; for example, the prevalence rates of hypoglycemia were 12.4% for International Classification of Diseases codes, 25.1% for an NLP algorithm, and 32.2% for combined algorithms. All the reviewed studies applied rule-based NLP algorithms to identify hypoglycemia.

Conclusions: The findings provided evidence that the application of NLP to analyze clinical notes improved the capture of hypoglycemic events, particularly when combined with the ICD-9 or ICD-10 codes and laboratory testing.

背景:准确识别低血糖患者是预防不良事件和死亡率的关键。自然语言处理(NLP)是人工智能的一种形式,它使用计算算法从文本数据中提取信息。当使用来自大量人群的电子健康记录数据源时,NLP是一种可扩展、高效和快速的方法,可以提取与低血糖相关的信息。目的:本系统综述的目的是综合应用NLP从电子病历临床记录中提取低血糖的文献。方法:在PubMed、Web of Science Core Collection、CINAHL (EBSCO)、PsycINFO (Ovid)、IEEE Xplore、Google Scholar和ACL Anthology中进行电子文献检索。关键词:低血糖、低血糖、NLP、机器学习。纳入标准包括应用NLP识别低血糖,报告与低血糖相关的结局,并以英文全文发表的研究。结果:本综述(n=8项研究)揭示了与低血糖相关的报告结果的异质性。在纳入的8项研究中,4项(50%)报告了任何水平的低血糖患病率为3.4%至46.2%。使用NLP分析临床记录,提高了使用《国际疾病分类》第九版(ICD-9)、《国际疾病分类》第十版(ICD-10)和实验室检测对未记录或遗漏的低血糖事件的捕捉。与单独的方法相比,NLP与ICD-9或ICD-10代码的结合显著提高了低血糖事件的识别率;例如,国际疾病分类代码的低血糖患病率为12.4%,NLP算法的患病率为25.1%,组合算法的患病率为32.2%。所有回顾的研究都应用基于规则的NLP算法来识别低血糖。结论:研究结果证明,应用NLP分析临床记录可以改善低血糖事件的捕获,特别是当与ICD-9或ICD-10代码和实验室测试相结合时。
{"title":"Identifying Patients With Hypoglycemia Using Natural Language Processing: Systematic Literature Review.","authors":"Yaguang Zheng,&nbsp;Victoria Vaughan Dickson,&nbsp;Saul Blecker,&nbsp;Jason M Ng,&nbsp;Brynne Campbell Rice,&nbsp;Gail D'Eramo Melkus,&nbsp;Liat Shenkar,&nbsp;Marie Claire R Mortejo,&nbsp;Stephen B Johnson","doi":"10.2196/34681","DOIUrl":"https://doi.org/10.2196/34681","url":null,"abstract":"<p><strong>Background: </strong>Accurately identifying patients with hypoglycemia is key to preventing adverse events and mortality. Natural language processing (NLP), a form of artificial intelligence, uses computational algorithms to extract information from text data. NLP is a scalable, efficient, and quick method to extract hypoglycemia-related information when using electronic health record data sources from a large population.</p><p><strong>Objective: </strong>The objective of this systematic review was to synthesize the literature on the application of NLP to extract hypoglycemia from electronic health record clinical notes.</p><p><strong>Methods: </strong>Literature searches were conducted electronically in PubMed, Web of Science Core Collection, CINAHL (EBSCO), PsycINFO (Ovid), IEEE Xplore, Google Scholar, and ACL Anthology. Keywords included hypoglycemia, low blood glucose, NLP, and machine learning. Inclusion criteria included studies that applied NLP to identify hypoglycemia, reported the outcomes related to hypoglycemia, and were published in English as full papers.</p><p><strong>Results: </strong>This review (n=8 studies) revealed heterogeneity of the reported results related to hypoglycemia. Of the 8 included studies, 4 (50%) reported that the prevalence rate of any level of hypoglycemia was 3.4% to 46.2%. The use of NLP to analyze clinical notes improved the capture of undocumented or missed hypoglycemic events using International Classification of Diseases, Ninth Revision (ICD-9), and International Classification of Diseases, Tenth Revision (ICD-10), and laboratory testing. The combination of NLP and ICD-9 or ICD-10 codes significantly increased the identification of hypoglycemic events compared with individual methods; for example, the prevalence rates of hypoglycemia were 12.4% for International Classification of Diseases codes, 25.1% for an NLP algorithm, and 32.2% for combined algorithms. All the reviewed studies applied rule-based NLP algorithms to identify hypoglycemia.</p><p><strong>Conclusions: </strong>The findings provided evidence that the application of NLP to analyze clinical notes improved the capture of hypoglycemic events, particularly when combined with the ICD-9 or ICD-10 codes and laboratory testing.</p>","PeriodicalId":52371,"journal":{"name":"JMIR Diabetes","volume":"7 2","pages":"e34681"},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9492666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Acceptance and Effect of Continuous Glucose Monitoring on Discharge From Hospital in Patients With Type 2 Diabetes: Open-label, Prospective, Controlled Study 2型糖尿病患者出院时持续血糖监测的接受程度及效果:开放标签、前瞻性、对照研究
Q2 Medicine Pub Date : 2022-05-09 DOI: 10.2196/35163
B. Depczynski, A. Poynten
Background Continuous glucose monitors (CGM) can provide detailed information on glucose excursions. There is little information on safe transitioning from hospital back to the community for patients who have had diabetes therapies adjusted in hospital and it is unclear whether newer technologies may facilitate this process. Objective Our aim was to determine whether offering CGM on discharge would be acceptable and if CGM initiated on hospital discharge in people with type 2 diabetes (T2DM) would reduce hospital re-presentations at 1 month. Methods This was an open-label study. Adult inpatients with T2DM, who were to be discharged home and required postdischarge glycemic stabilization, were offered usual care consisting of clinic review at 2 weeks and at 3 months. In addition to usual care, participants in the intervention arm were provided with a Libre flash glucose monitoring system (Abbott Australia). An initial run-in phase for the first 20 participants was planned, where all consenting participants were enrolled in an active arm. Subsequently, all participants were to be randomized to the active arm or usual care control group. Results Of 237 patients screened during their hospital admission, 34 had comorbidities affecting cognition that prevented informed consent and affected their ability to learn to use the CGM device. In addition, 21 were not able to be approached as the material was only in English. Of 101 potential participants who fulfilled eligibility criteria, 19 provided consent and were enrolled. Of the 82 patients who declined to participate, 31 advised that the learning of a new task toward discharge was overwhelming or too stressful and 26 were not interested, with no other details. Due to poor recruitment, the study was terminated without entering the randomization phase to determine whether CGM could reduce readmission rate. Conclusions These results suggest successful and equitable implementation of telemedicine programs requires that any human factors such as language, cognition, and possible disengagement be addressed. Recovery from acute illness may not be the ideal time for introduction of newer technologies or may require more novel implementation frameworks.
背景:连续血糖监测仪(CGM)可以提供葡萄糖漂移的详细信息。关于在医院调整糖尿病治疗的患者从医院安全过渡到社区的信息很少,也不清楚新技术是否可以促进这一过程。我们的目的是确定出院时进行CGM是否可以接受,以及2型糖尿病(T2DM)患者出院时进行CGM是否会减少1个月后的再次住院。方法采用开放标签研究。成年T2DM住院患者将出院回家并要求出院后血糖稳定,他们接受常规护理,包括2周和3个月的临床复查。除常规护理外,干预组的参与者还使用Libre瞬时血糖监测系统(Abbott Australia)。计划对前20名参与者进行初始磨合阶段,所有同意的参与者都参加了一个活跃的小组。随后,所有参与者被随机分配到积极组或常规护理对照组。结果在住院期间筛查的237例患者中,34例患有影响认知的合并症,妨碍了知情同意并影响了他们学习使用CGM装置的能力。此外,有21人无法接触,因为材料只有英文。在101名符合资格标准的潜在参与者中,有19人同意并入组。在拒绝参与的82名患者中,31人表示,在出院前学习一项新任务是压倒性的或压力太大,26人不感兴趣,没有其他细节。由于招募不良,研究未进入随机化阶段就终止,以确定CGM是否可以降低再入院率。这些结果表明,成功和公平地实施远程医疗计划需要解决任何人为因素,如语言、认知和可能的脱离。急性疾病的恢复期可能不是引进新技术的理想时机,或者可能需要更新颖的实施框架。
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引用次数: 1
Effects of a Novel Blood Glucose Forecasting Feature on Glycemic Management and Logging in Adults With Type 2 Diabetes Using One Drop: Retrospective Cohort Study 一种新的血糖预测功能对成人2型糖尿病患者血糖管理和记录的影响:回顾性队列研究
Q2 Medicine Pub Date : 2022-05-03 DOI: 10.2196/34624
Steven D Imrisek, Matthew Lee, D. Goldner, Harpreet Nagra, L. Lavaysse, J. Hoy-Rosas, J. Dachis, L. Sears
Background Personalized feedback is an effective behavior change technique frequently incorporated into mobile health (mHealth) apps. Innovations in data science create opportunities for leveraging the wealth of user data accumulated by mHealth apps to generate personalized health forecasts. One Drop’s digital program is one of the first to implement blood glucose forecasts for people with type 2 diabetes. The impact of these forecasts on behavior and glycemic management has not been evaluated to date. Objective This study sought to evaluate the impact of exposure to blood glucose forecasts on blood glucose logging behavior, average blood glucose, and percentage of glucose points in range. Methods This retrospective cohort study examined people with type 2 diabetes who first began using One Drop to record their blood glucose between 2019 and 2021. Cohorts included those who received blood glucose forecasts and those who did not receive forecasts. The cohorts were compared to evaluate the effect of exposure to blood glucose forecasts on logging activity, average glucose, and percentage of glucose readings in range, after controlling for potential confounding factors. Data were analyzed using analysis of covariance (ANCOVA) and regression analyses. Results Data from a total of 1411 One Drop users with type 2 diabetes and elevated baseline glucose were analyzed. Participants (60.6% male, 795/1311; mean age 50.2 years, SD 11.8) had diabetes for 7.1 years on average (SD 7.9). After controlling for potential confounding factors, blood glucose forecasts were associated with more frequent blood glucose logging (P=.004), lower average blood glucose (P<.001), and a higher percentage of readings in range (P=.03) after 12 weeks. Blood glucose logging partially mediated the relationship between exposure to forecasts and average glucose. Conclusions Individuals who received blood glucose forecasts had significantly lower average glucose, with a greater amount of glucose measurements in a healthy range after 12 weeks compared to those who did not receive forecasts. Glucose logging was identified as a partial mediator of the relationship between forecast exposure and week-12 average glucose, highlighting a potential mechanism through which glucose forecasts exert their effect. When administered as a part of a comprehensive mHealth program, blood glucose forecasts may significantly improve glycemic management among people living with type 2 diabetes.
个性化反馈是一种有效的行为改变技术,经常被纳入移动健康应用程序。数据科学的创新为利用移动健康应用程序积累的大量用户数据来生成个性化的健康预测创造了机会。One Drop的数字项目是首批为2型糖尿病患者实施血糖预测的项目之一。这些预测对行为和血糖控制的影响至今尚未得到评估。目的本研究旨在评估暴露于血糖预测对血糖记录行为、平均血糖和范围内血糖点百分比的影响。方法:这项回顾性队列研究调查了2019年至2021年间首次开始使用One Drop记录血糖的2型糖尿病患者。队列包括接受血糖预测的人和没有接受血糖预测的人。在控制了潜在的混杂因素后,对这些队列进行比较,以评估暴露于血糖预测对记录活动、平均血糖和范围内血糖读数百分比的影响。数据分析采用协方差分析(ANCOVA)和回归分析。结果分析了1411例One Drop 2型糖尿病患者基线血糖升高的数据。参与者(60.6%男性,795/1311;平均年龄50.2岁(SD 11.8),平均患有糖尿病7.1年(SD 7.9)。在控制了潜在的混杂因素后,血糖预测与12周后更频繁的血糖记录(P= 0.004)、更低的平均血糖(P< 0.001)和更高的读数百分比相关(P= 0.03)。血糖记录部分介导了暴露于预测和平均血糖之间的关系。结论:与未接受血糖预测的个体相比,接受血糖预测的个体在12周后的平均血糖显著降低,在健康范围内的葡萄糖测量量更多。葡萄糖记录被确定为预测暴露与第12周平均葡萄糖之间关系的部分中介,强调了葡萄糖预测发挥其作用的潜在机制。作为综合移动健康项目的一部分,血糖预测可能会显著改善2型糖尿病患者的血糖管理。
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引用次数: 1
GoFundMe as a Medical Plan: Ecological Study of Crowdfunding Insulin Success. GoFundMe作为医疗计划:胰岛素众筹成功的生态学研究。
Q2 Medicine Pub Date : 2022-04-15 DOI: 10.2196/33205
Julia E Blanchette, M J Tran, Ernest G Grigorian, Eli Iacob, Linda S Edelman, Tamara K Oser, Michelle L Litchman

Background: Individuals in need of medical care turn to crowdfunding websites to engage a "crowd" or group for financial support. In the last decade, access to insulin has decreased considerably for several reasons, including the rising cost of insulin, increasing popularity of high-deductible insurance plans, and increasing insurance premiums. Many people with diabetes are forced to ration or go without insulin, and they turn to crowdfunding websites to seek financial donations to purchase insulin needed to reduce health risks and mortality, and sustain quality of life.

Objective: This study aimed to explore crowdfunding campaign requests to purchase insulin in the United States.

Methods: In this retrospective, quantitative, and qualitative study, we coded the text of GoFundMe online crowdfunding campaigns and viral measures (shares, hearts, and comments) from February 25 to April 15, 2019. We described campaigns (N=205) and explored the factors associated with campaign success using correlations and qualitative thematic analysis.

Results: The majority of campaigns were initiated by middle-aged adults (age 26-64 years; 77/205, 37.6%), those with type 1 diabetes (94/205, 45.9%), and those needing funds owing to insurance coverage issues (125/205, 61.0%). The factors associated with campaign success included requests for ≤US $500 (P=.007) and higher viral measures (shares, P=.007; hearts, P<.001; comments, P=.002). The following 4 themes emerged from the campaign text: (1) desire for self-management and survival, (2) diabetes management untenable given insulin access, (3) aftermath of insulin unaffordability, and (4) privacy issues with crowdfunding. Campaign comments were both supportive (tangible, informational, and emotional) and unsupportive (questioned the need for the campaign and deemed crowdfunding inappropriate).

Conclusions: Despite crowdfunding websites being used to support the purchase of insulin, campaigns raised only a fraction of the money requested. Therefore, GoFundMe campaigns are not a reliable solution to obtain funds for insulin in the United States. Applying quantitative and qualitative methods is adequate to analyze online crowdfunding for costs of medications such as insulin. However, it is critical for people with diabetes to use resources other than online crowdfunding to access and obtain insulin owing to low success rates. Clinicians should routinely assess difficulty accessing or affording insulin, and federal health care policies should support lowering the cost of insulin.

背景:需要医疗护理的个人转向众筹网站,以吸引“人群”或团体获得财务支持。在过去十年中,由于胰岛素成本的上升、高免赔额保险计划的日益普及以及保险费的增加,胰岛素的可及性大大降低。许多糖尿病患者被迫配给胰岛素或不使用胰岛素,他们转向众筹网站寻求资金捐赠,以购买所需的胰岛素,以降低健康风险和死亡率,并维持生活质量。目的:本研究旨在了解美国民众购买胰岛素的众筹活动。方法:在这项回顾性、定量和定性研究中,我们对2019年2月25日至4月15日期间GoFundMe在线众筹活动的文本和病毒式度量(分享、关注和评论)进行了编码。我们描述了活动(N=205),并使用相关性和定性主题分析探索了与活动成功相关的因素。结果:大多数运动是由中年人发起的(26-64岁;1型糖尿病患者(94/205,45.9%)和因保险问题需要资金的患者(125/205,61.0%)。与活动成功相关的因素包括≤500美元的请求(P=.007)和更高的病毒式传播措施(股票,P=.007;结论:尽管众筹网站被用来支持胰岛素的购买,但这些活动只筹集到所需资金的一小部分。因此,在美国,GoFundMe活动并不是获得胰岛素资金的可靠解决方案。使用定量和定性方法足以分析胰岛素等药物成本的在线众筹。然而,由于成功率较低,糖尿病患者使用在线众筹以外的资源获取和获得胰岛素至关重要。临床医生应定期评估获得或负担胰岛素的困难,联邦卫生保健政策应支持降低胰岛素的成本。
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引用次数: 3
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JMIR Diabetes
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