Pub Date : 2021-04-08DOI: 10.1186/s42492-021-00074-0
Wu Yang, Chonglei Zhang, Jiaqi Zeng, Wei Song
Acoustic/ultrasonic sensors are devices that can convert mechanical energy into electrical signals. The Fabry-Perot cavity is processed on the end face of the double-clad fiber by a two-photon three-dimensional lithography machine. In this study, the outer diameter of the core cladding was 250 μm, the diameter of the core was 9 μm, and the microcavity sensing unit was only 30 μm. It could measure ultrasonic signals with high precision. The characteristics of the proposed ultrasonic sensor were investigated, and its feasibility was proven through experiments. Its design has a small size and can replace a larger ultrasonic detector device for photoacoustic signal detection. The sensor is applicable to the field of biomedical information technology, including medical diagnosis, photoacoustic endoscopy, and photoacoustic imaging.
{"title":"Ultrasonic signal detection based on Fabry-Perot cavity sensor.","authors":"Wu Yang, Chonglei Zhang, Jiaqi Zeng, Wei Song","doi":"10.1186/s42492-021-00074-0","DOIUrl":"10.1186/s42492-021-00074-0","url":null,"abstract":"<p><p>Acoustic/ultrasonic sensors are devices that can convert mechanical energy into electrical signals. The Fabry-Perot cavity is processed on the end face of the double-clad fiber by a two-photon three-dimensional lithography machine. In this study, the outer diameter of the core cladding was 250 μm, the diameter of the core was 9 μm, and the microcavity sensing unit was only 30 μm. It could measure ultrasonic signals with high precision. The characteristics of the proposed ultrasonic sensor were investigated, and its feasibility was proven through experiments. Its design has a small size and can replace a larger ultrasonic detector device for photoacoustic signal detection. The sensor is applicable to the field of biomedical information technology, including medical diagnosis, photoacoustic endoscopy, and photoacoustic imaging.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2021-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-021-00074-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25570359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Photoacoustic microscopy is an in vivo imaging technology based on the photoacoustic effect. It is widely used in various biomedical studies because it can provide high-resolution images while being label-free, safe, and harmless to biological tissue. Polygon-scanning is an effective scanning method in photoacoustic microscopy that can realize fast imaging of biological tissue with a large field of view. However, in polygon-scanning, fluctuations of the rotating motor speed and the geometric error of the rotating mirror cause image distortions, which seriously affect the photoacoustic-microscopy imaging quality. To improve the image quality of photoacoustic microscopy using polygon-scanning, an image correction method is proposed based on accurate ultrasound positioning. In this method, the photoacoustic and ultrasound imaging data of the sample are simultaneously obtained, and the angle information of each mirror used in the polygon-scanning is extracted from the ultrasonic data to correct the photoacoustic images. Experimental results show that the proposed method can significantly reduce image distortions in photoacoustic microscopy, with the image dislocation offset decreasing from 24.774 to 10.365 μm.
{"title":"Recovery of photoacoustic images based on accurate ultrasound positioning.","authors":"Yinhao Pan, Ningbo Chen, Liangjian Liu, Chengbo Liu, Zhiqiang Xu, Jianhui Zhang","doi":"10.1186/s42492-021-00072-2","DOIUrl":"https://doi.org/10.1186/s42492-021-00072-2","url":null,"abstract":"<p><p>Photoacoustic microscopy is an in vivo imaging technology based on the photoacoustic effect. It is widely used in various biomedical studies because it can provide high-resolution images while being label-free, safe, and harmless to biological tissue. Polygon-scanning is an effective scanning method in photoacoustic microscopy that can realize fast imaging of biological tissue with a large field of view. However, in polygon-scanning, fluctuations of the rotating motor speed and the geometric error of the rotating mirror cause image distortions, which seriously affect the photoacoustic-microscopy imaging quality. To improve the image quality of photoacoustic microscopy using polygon-scanning, an image correction method is proposed based on accurate ultrasound positioning. In this method, the photoacoustic and ultrasound imaging data of the sample are simultaneously obtained, and the angle information of each mirror used in the polygon-scanning is extracted from the ultrasonic data to correct the photoacoustic images. Experimental results show that the proposed method can significantly reduce image distortions in photoacoustic microscopy, with the image dislocation offset decreasing from 24.774 to 10.365 μm.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-021-00072-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25528362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-19DOI: 10.1186/s42492-021-00073-1
Sung-Liang Chen, Chao Tian
Photoacoustic (PA) imaging has been widely used in biomedical research and preclinical studies during the past two decades. It has also been explored for nondestructive testing and evaluation (NDT/E) and for industrial applications. This paper describes the basic principles of PA technology for NDT/E and its applications in recent years. PA technology for NDT/E includes the use of a modulated continuous-wave laser and a pulsed laser for PA wave excitation, PA-generated ultrasonic waves, and all-optical PA wave excitation and detection. PA technology for NDT/E has demonstrated broad applications, including the imaging of railway cracks and defects, the imaging of Li metal batteries, the measurements of the porosity and Young's modulus, the detection of defects and damage in silicon wafers, and a visualization of underdrawings in paintings.
{"title":"Review recent developments in photoacoustic imaging and sensing for nondestructive testing and evaluation.","authors":"Sung-Liang Chen, Chao Tian","doi":"10.1186/s42492-021-00073-1","DOIUrl":"https://doi.org/10.1186/s42492-021-00073-1","url":null,"abstract":"<p><p>Photoacoustic (PA) imaging has been widely used in biomedical research and preclinical studies during the past two decades. It has also been explored for nondestructive testing and evaluation (NDT/E) and for industrial applications. This paper describes the basic principles of PA technology for NDT/E and its applications in recent years. PA technology for NDT/E includes the use of a modulated continuous-wave laser and a pulsed laser for PA wave excitation, PA-generated ultrasonic waves, and all-optical PA wave excitation and detection. PA technology for NDT/E has demonstrated broad applications, including the imaging of railway cracks and defects, the imaging of Li metal batteries, the measurements of the porosity and Young's modulus, the detection of defects and damage in silicon wafers, and a visualization of underdrawings in paintings.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-021-00073-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25496892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-01DOI: 10.1186/s42492-021-00071-3
Hermann Pflüger
A vast quantity of art in existence today is inaccessible to individuals. If people want to know the different types of art that exist, how individual works are connected, and how works of art are interpreted and discussed in the context of other works, they must utilize means other than simply viewing the art. Therefore, this paper proposes a language to analyze, describe, and explore collections of visual art (LadeCA). LadeCA combines human interpretation and automatic analyses of images, allowing users to assess collections of visual art without viewing every image in them. This paper focuses on the lexical base of LadeCA. It also outlines how collections of visual art can be analyzed, described, and explored using a LadeCA vocabulary. Additionally, the relationship between LadeCA and indexing systems, such as ICONCLASS or AAT, is demonstrated, and ways in which LadeCA and indexing systems can complement each other are highlighted. Video abstract.
{"title":"A language to analyze, describe, and explore collections of visual art.","authors":"Hermann Pflüger","doi":"10.1186/s42492-021-00071-3","DOIUrl":"https://doi.org/10.1186/s42492-021-00071-3","url":null,"abstract":"<p><p>A vast quantity of art in existence today is inaccessible to individuals. If people want to know the different types of art that exist, how individual works are connected, and how works of art are interpreted and discussed in the context of other works, they must utilize means other than simply viewing the art. Therefore, this paper proposes a language to analyze, describe, and explore collections of visual art (LadeCA). LadeCA combines human interpretation and automatic analyses of images, allowing users to assess collections of visual art without viewing every image in them. This paper focuses on the lexical base of LadeCA. It also outlines how collections of visual art can be analyzed, described, and explored using a LadeCA vocabulary. Additionally, the relationship between LadeCA and indexing systems, such as ICONCLASS or AAT, is demonstrated, and ways in which LadeCA and indexing systems can complement each other are highlighted. Video abstract.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-021-00071-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25417663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-23DOI: 10.1186/s42492-021-00070-4
Xue Bai, Xu Li, Jun Ma, Bai-Ou Guan
In this study, a virtual-point concept was introduced into fiber-laser photoacoustic tomography to improve the elevational image resolution. The flexible fiber laser was bent into an arc shape to conform to the ultrasound wavefront, which formed an ultrasound focus at the center of the arc. The synthetic aperture focusing technique was utilized to reconstruct the images; as a result, the elevational resolution particularly within the out-of-focus region was considerably improved compared to the resolution of an image retrieved by multiplexing the PA time-resolved signals with sound velocity. The all-optical fiber-laser photoacoustic tomography system with a high spatial resolution has potential for various applications, including biomedical research and preclinical/clinical diagnosis.
{"title":"Improvement in resolution of fiber-laser photoacoustic tomography based on a virtual-point concept.","authors":"Xue Bai, Xu Li, Jun Ma, Bai-Ou Guan","doi":"10.1186/s42492-021-00070-4","DOIUrl":"https://doi.org/10.1186/s42492-021-00070-4","url":null,"abstract":"<p><p>In this study, a virtual-point concept was introduced into fiber-laser photoacoustic tomography to improve the elevational image resolution. The flexible fiber laser was bent into an arc shape to conform to the ultrasound wavefront, which formed an ultrasound focus at the center of the arc. The synthetic aperture focusing technique was utilized to reconstruct the images; as a result, the elevational resolution particularly within the out-of-focus region was considerably improved compared to the resolution of an image retrieved by multiplexing the PA time-resolved signals with sound velocity. The all-optical fiber-laser photoacoustic tomography system with a high spatial resolution has potential for various applications, including biomedical research and preclinical/clinical diagnosis.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25402100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-30DOI: 10.1186/s42492-020-00068-4
Yafei Zhu, Mengyao Bao, Miaomiao Jiang, Jincai Chang, Jianzhong Cui
The elimination of intracranial hematomas has received widespread attention and the interactions between hemolytic agents and hematomas have become a hot research topic. In this study, we used the Navier-Stokes equation to describe the flow control equation for hemolytic agents in a tube and used Fick's law and the Maxwell-Stefan diffusion theory to describe the diffusion and mass transfer of hemolytic agents and hematomas. The physical fields and initial boundary conditions were set according to the parametric properties of the fluid and drainage tube. The COMSOL Multiphysics software was used to simulate the streamline distribution of hemolytic agents in a bifurcated drainage tube. Additionally, the diffusion behaviors of the hemolytic agents into hematomas were simulated and visual analysis of coupled multiphysics was performed to realize the digitization and visualization of engineering fluid problems and contribute to the field of medical engineering.
{"title":"Visual analysis of flow and diffusion of hemolytic agents and hematomas.","authors":"Yafei Zhu, Mengyao Bao, Miaomiao Jiang, Jincai Chang, Jianzhong Cui","doi":"10.1186/s42492-020-00068-4","DOIUrl":"https://doi.org/10.1186/s42492-020-00068-4","url":null,"abstract":"<p><p>The elimination of intracranial hematomas has received widespread attention and the interactions between hemolytic agents and hematomas have become a hot research topic. In this study, we used the Navier-Stokes equation to describe the flow control equation for hemolytic agents in a tube and used Fick's law and the Maxwell-Stefan diffusion theory to describe the diffusion and mass transfer of hemolytic agents and hematomas. The physical fields and initial boundary conditions were set according to the parametric properties of the fluid and drainage tube. The COMSOL Multiphysics software was used to simulate the streamline distribution of hemolytic agents in a bifurcated drainage tube. Additionally, the diffusion behaviors of the hemolytic agents into hematomas were simulated and visual analysis of coupled multiphysics was performed to realize the digitization and visualization of engineering fluid problems and contribute to the field of medical engineering.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-020-00068-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25311590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Classes of tree-based networks.","authors":"Mareike Fischer, Lina Herbst, Michelle Galla, Yangjing Long, Kristina Wicke","doi":"10.1186/s42492-021-00069-x","DOIUrl":"https://doi.org/10.1186/s42492-021-00069-x","url":null,"abstract":"","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-021-00069-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38781478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-11DOI: 10.1186/s42492-020-00067-5
Xiufeng Li, Victor T C Tsang, Lei Kang, Yan Zhang, Terence T W Wong
Laser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 μm has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.
{"title":"High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging.","authors":"Xiufeng Li, Victor T C Tsang, Lei Kang, Yan Zhang, Terence T W Wong","doi":"10.1186/s42492-020-00067-5","DOIUrl":"https://doi.org/10.1186/s42492-020-00067-5","url":null,"abstract":"<p><p>Laser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 μm has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"4 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42492-020-00067-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38805579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurodegenerative disorders are commonly characterized by atrophy of the brain which is caused by neuronal loss. Ventricles are one of the prominent structures in the brain; their shape changes, due to their content, the cerebrospinal fluid. Analyzing the morphological changes of ventricles, aids in the diagnosis of atrophy, for which the region of interest needs to be separated from the background. This study presents a modified distance regularized level set evolution segmentation method, incorporating regional intensity information. The proposed method is implemented for segmenting ventricles from brain images for normal and atrophy subjects of magnetic resonance imaging and computed tomography images. Results of the proposed method were compared with ground truth images and produced sensitivity in the range of 65%-90%, specificity in the range of 98%-99%, and accuracy in the range of 95%-98%. Peak signal to noise ratio and structural similarity index were also used as performance measures for determining segmentation accuracy: 95% and 0.95, respectively. The parameters of level set formulation vary for different datasets. An optimization procedure was followed to fine tune parameters. The proposed method was found to be efficient and robust against noisy images. The proposed method is adaptive and multimodal.
{"title":"Modified distance regularized level set evolution for brain ventricles segmentation.","authors":"Thirumagal Jayaraman, Sravan Reddy M, Manjunatha Mahadevappa, Anup Sadhu, Pranab Kumar Dutta","doi":"10.1186/s42492-020-00064-8","DOIUrl":"https://doi.org/10.1186/s42492-020-00064-8","url":null,"abstract":"<p><p>Neurodegenerative disorders are commonly characterized by atrophy of the brain which is caused by neuronal loss. Ventricles are one of the prominent structures in the brain; their shape changes, due to their content, the cerebrospinal fluid. Analyzing the morphological changes of ventricles, aids in the diagnosis of atrophy, for which the region of interest needs to be separated from the background. This study presents a modified distance regularized level set evolution segmentation method, incorporating regional intensity information. The proposed method is implemented for segmenting ventricles from brain images for normal and atrophy subjects of magnetic resonance imaging and computed tomography images. Results of the proposed method were compared with ground truth images and produced sensitivity in the range of 65%-90%, specificity in the range of 98%-99%, and accuracy in the range of 95%-98%. Peak signal to noise ratio and structural similarity index were also used as performance measures for determining segmentation accuracy: 95% and 0.95, respectively. The parameters of level set formulation vary for different datasets. An optimization procedure was followed to fine tune parameters. The proposed method was found to be efficient and robust against noisy images. The proposed method is adaptive and multimodal.</p>","PeriodicalId":52384,"journal":{"name":"Visual Computing for Industry, Biomedicine, and Art","volume":"3 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38341948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}