Pub Date : 2024-03-01DOI: 10.1016/j.jaclp.2023.11.687
Charalambia Louka M.D., Stephanie Chiao M.D.
Background
Ketamine is an anesthetic and analgesic known for its psychotomimetic properties, such as dissociation and altered perception. Acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) are characterized by unwanted memories, intrusive thoughts, and dissociative flashbacks following an acute traumatic event. It is unknown how analgesic ketamine affects the symptomatology of ASD when administered to patients in the posttraumatic period.
Objective and Methods
In this article, we present the case of a 26-year-old man who sustained gunshot wounds and developed worsened ASD after receiving analgesic ketamine. We also present a review of the current literature on peritraumatic ketamine and its subsequent effect on ASD and PTSD.
Results
In 2 out of 3 articles examining ketamine and ASD, ketamine was associated with worsened symptomatology of ASD. There were 6 articles examining ketamine and PTSD. In 1 of 6 articles, ketamine was associated with increased incidence and/or severity of PTSD, and in 2 of 6, it was associated with decreased incidence and/or severity of PTSD. There was no relationship between ketamine and subsequent PTSD in 3 of 6 articles.
Conclusion
We conclude that ketamine's psychotomimetic properties may exacerbate the dissociative and perceptual symptoms of ASD, but its long-term effects on PTSD are still unclear. In patients with preexisting ASD, the potential risks and benefits of using analgesic ketamine must be weighed carefully.
{"title":"Intravenous Ketamine Exacerbating Symptoms of Acute Stress Disorder: A Case Report and Systematized Review of Existing Literature","authors":"Charalambia Louka M.D., Stephanie Chiao M.D.","doi":"10.1016/j.jaclp.2023.11.687","DOIUrl":"10.1016/j.jaclp.2023.11.687","url":null,"abstract":"<div><h3>Background</h3><p><span>Ketamine<span> is an anesthetic and analgesic known for its psychotomimetic properties, such as dissociation and altered perception. </span></span>Acute stress disorder<span> (ASD) and posttraumatic stress disorder<span><span> (PTSD) are characterized by unwanted memories, intrusive thoughts, and dissociative flashbacks following an acute traumatic event. It is unknown how analgesic ketamine affects the </span>symptomatology of ASD when administered to patients in the posttraumatic period.</span></span></p></div><div><h3>Objective and Methods</h3><p>In this article, we present the case of a 26-year-old man who sustained gunshot wounds and developed worsened ASD after receiving analgesic ketamine. We also present a review of the current literature on peritraumatic ketamine and its subsequent effect on ASD and PTSD.</p></div><div><h3>Results</h3><p>In 2 out of 3 articles examining ketamine and ASD, ketamine was associated with worsened symptomatology of ASD. There were 6 articles examining ketamine and PTSD. In 1 of 6 articles, ketamine was associated with increased incidence and/or severity of PTSD, and in 2 of 6, it was associated with decreased incidence and/or severity of PTSD. There was no relationship between ketamine and subsequent PTSD in 3 of 6 articles.</p></div><div><h3>Conclusion</h3><p>We conclude that ketamine's psychotomimetic properties may exacerbate the dissociative and perceptual symptoms<span> of ASD, but its long-term effects on PTSD are still unclear. In patients with preexisting ASD, the potential risks and benefits of using analgesic ketamine must be weighed carefully.</span></p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 2","pages":"Pages 204-213"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.jaclp.2023.11.686
Patrick C. Ryan B.A. , Nathan J. Lowry B.A. , Edwin Boudreaux Ph.D. , Deborah J. Snyder M.S.W., L.C.S.W.-C. , Cynthia A. Claassen M.D. , Colin J. Harrington M.D. , David A. Jobes Ph.D. , Jeffrey A. Bridge Ph.D. , Maryland Pao M.D. , Lisa M. Horowitz Ph.D., M.P.H.
Background
Medically ill adults are at elevated risk for suicide. Chronic pain and hopelessness are associated with suicide; however, few studies have examined the interaction between chronic pain and hopelessness in predicting suicide risk among hospitalized adults.
Objective
This study aimed to describe the association between chronic pain, hopelessness, and suicide risk, defined as recent suicidal ideation or lifetime suicidal behavior. In addition, we examined the interaction between chronic pain and hopelessness.
Methods
This was a secondary analysis of a multisite study to validate the Ask Suicide-Screening Questions (ASQ) among adult medical inpatients. Participants reported if they experienced chronic pain that impacted daily life and if they felt hopeless about their medical condition and provided their current pain rating on a 1 to 10 scale, with 10 being the most severe pain. A t-test compared pain severity scores by ASQ outcome. A binary logistic regression model described the association between chronic pain, hopelessness, and suicide risk; parameter estimates are expressed as odds ratios (OR) for interpretation. The interaction between chronic pain and hopelessness was examined in both the transformed (logit) and natural (probability) scales of the generalized linear model.
Results
The sample included 720 participants (53.2% male, 62.4% White, mean age: 50.1 [16.3] years, range = 18–93). On the ASQ, 15.7% (113/720) of patients screened positive. Half (360/720) of the sample self-reported chronic pain. Individuals who screened positive had higher pain rating scores than those who screened negative (t = −4.2, df = 147.6, P < 0.001). Among all patients, 27.2% (196/720) felt hopeless about their medical condition. In the logistic regression model, patients with chronic pain (adjusted OR: 2.29, 95% confidence interval [CI]: 1.21–4.43, P = 0.01) or hopelessness (adjusted OR: 5.69, 95% CI: 2.52–12.64, P < 0.001) had greater odds of screening positive on the ASQ. The interaction effect between pain and hopelessness was not significant in the transformed (B = −0.15, 95% CI: −1.11 to 0.82, P = 0.76) or natural (B = 0.08, 95% CI: −0.07 to 0.23, P = 0.28) scale.
Conclusions
There were significant independent associations between (1) chronic pain and suicide risk and between (2) hopelessness and suicide risk. Future research should examine the temporality and mechanisms underlying these relationships to inform prevention efforts for medically ill adults.
{"title":"Chronic Pain, Hopelessness, and Suicide Risk Among Adult Medical Inpatients","authors":"Patrick C. Ryan B.A. , Nathan J. Lowry B.A. , Edwin Boudreaux Ph.D. , Deborah J. Snyder M.S.W., L.C.S.W.-C. , Cynthia A. Claassen M.D. , Colin J. Harrington M.D. , David A. Jobes Ph.D. , Jeffrey A. Bridge Ph.D. , Maryland Pao M.D. , Lisa M. Horowitz Ph.D., M.P.H.","doi":"10.1016/j.jaclp.2023.11.686","DOIUrl":"10.1016/j.jaclp.2023.11.686","url":null,"abstract":"<div><h3>Background</h3><p>Medically ill adults are at elevated risk for suicide. Chronic pain and hopelessness are associated with suicide; however, few studies have examined the interaction between chronic pain and hopelessness in predicting suicide risk among hospitalized adults.</p></div><div><h3>Objective</h3><p>This study aimed to describe the association between chronic pain, hopelessness, and suicide risk, defined as recent suicidal ideation or lifetime suicidal behavior. In addition, we examined the interaction between chronic pain and hopelessness.</p></div><div><h3>Methods</h3><p>This was a secondary analysis of a multisite study to validate the Ask Suicide-Screening Questions (ASQ) among adult medical inpatients. Participants reported if they experienced chronic pain that impacted daily life and if they felt hopeless about their medical condition and provided their current pain rating on a 1 to 10 scale, with 10 being the most severe pain. A <em>t</em><span><span>-test compared pain severity scores by ASQ outcome. A binary logistic regression model described the association between chronic pain, hopelessness, and suicide risk; parameter estimates are expressed as odds ratios (OR) for interpretation. The interaction between chronic pain and hopelessness was examined in both the transformed (logit) and natural (probability) scales of the </span>generalized linear model.</span></p></div><div><h3>Results</h3><p>The sample included 720 participants (53.2% male, 62.4% White, mean age: 50.1 [16.3] years, range = 18–93). On the ASQ, 15.7% (113/720) of patients screened positive. Half (360/720) of the sample self-reported chronic pain. Individuals who screened positive had higher pain rating scores than those who screened negative (t = −4.2, df = 147.6, <em>P</em> < 0.001). Among all patients, 27.2% (196/720) felt hopeless about their medical condition. In the logistic regression model, patients with chronic pain (adjusted OR: 2.29, 95% confidence interval [CI]: 1.21–4.43, <em>P</em> = 0.01) or hopelessness (adjusted OR: 5.69, 95% CI: 2.52–12.64, <em>P</em> < 0.001) had greater odds of screening positive on the ASQ. The interaction effect between pain and hopelessness was not significant in the transformed (B = −0.15, 95% CI: −1.11 to 0.82, <em>P</em> = 0.76) or natural (B = 0.08, 95% CI: −0.07 to 0.23, <em>P</em> = 0.28) scale.</p></div><div><h3>Conclusions</h3><p>There were significant independent associations between (1) chronic pain and suicide risk and between (2) hopelessness and suicide risk. Future research should examine the temporality and mechanisms underlying these relationships to inform prevention efforts for medically ill adults.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 2","pages":"Pages 126-135"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.jaclp.2023.09.004
Sanndy Infante M.Sc. , Alex Behn Ph.D. , Matías González Ph.D. , Luis Pintor Ph.D. , Eduardo Franco Ph.D. , Pablo Araya M.D. , José R. Maldonado Ph.D.
<div><h3>Background</h3><p>Delirium is the most prevalent neuropsychiatric syndrome experienced by patients admitted to inpatient clinical units, occurring in at least 20% of medically hospitalized patients and up to 85% of those admitted to critical care units. Although current guidelines recommend the implementation of universal prevention strategies, the use of management strategies largely depends on constant surveillance and screening. This allows for the timely diagnosis and correction of its underlying causes and implementation of management strategies.</p></div><div><h3>Objective</h3><p>It was to adapt and analyze the Spanish adaptation of the Stanford Proxy Test for Delirium (S-PTD<em>sv</em>) instrument for its use among Spanish-speaking populations. The S-PTD is an instrument consisting of 13 observational items to be completed by a clinician observer, usually the patient's nurse. The completion of the questionnaire takes about 1 minute and does not require the active participation of the person evaluated, which has important clinical advantages compared to other available instruments (e.g., the Confusion Assessment Method).</p></div><div><h3>Methods</h3><p><span>The psychometric properties of the S-PTD</span><em>sv</em><span> were evaluated in a population of 123 patients using a quantitative, cross-sectional design. All subjects were over 18 years of age and hospitalized in various inpatient medico-surgical and intensive care unit services, either at the Barcelona Clinical Hospital (Barcelona, Spain) or the UC-Christus Health Network Clinical Hospital (Santiago, Chile, S.A.). The ultimate diagnosis of delirium was made by a member of the Psychiatry<span> Consult Service by means of an independent neuropsychiatric evaluation based on the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, published in 2013, which is the latest version of the diagnostic manual. All study tests were performed by study personnel who were blinded to each other's test results within an hour of each other.</span></span></p></div><div><h3>Results</h3><p>In the receiver operator characteristic (ROC) curve analysis, the S-PTD<em>sv</em> demonstrated excellent classification qualities when compared with the DSM-5 as the classification reference standard. Using a cutoff point of ≥3, the S-PTD<em>sv</em> had a sensitivity of 94% and a specificity of 97%. The area under the curve indicator was equal to 0.95, suggesting the S-PTD<em>sv</em> has an excellent overall performance in accurately identifying cases of delirium. Accordingly, the S-PTD<em>sv</em><span>'s positive predictive value = 0.93, and the negative predictive value = 0.97. The internal reliability measured with Cronbach's alpha was 0.96. Confirmatory factor analysis<span> revealed a 1-dimensional structure with high loadings (>0.72), demonstrating that all items similarly contribute to the total diagnostic dimension, suggesting adequate construct validity. T
{"title":"Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in Two Clinical Spanish-Speaking Communities","authors":"Sanndy Infante M.Sc. , Alex Behn Ph.D. , Matías González Ph.D. , Luis Pintor Ph.D. , Eduardo Franco Ph.D. , Pablo Araya M.D. , José R. Maldonado Ph.D.","doi":"10.1016/j.jaclp.2023.09.004","DOIUrl":"10.1016/j.jaclp.2023.09.004","url":null,"abstract":"<div><h3>Background</h3><p>Delirium is the most prevalent neuropsychiatric syndrome experienced by patients admitted to inpatient clinical units, occurring in at least 20% of medically hospitalized patients and up to 85% of those admitted to critical care units. Although current guidelines recommend the implementation of universal prevention strategies, the use of management strategies largely depends on constant surveillance and screening. This allows for the timely diagnosis and correction of its underlying causes and implementation of management strategies.</p></div><div><h3>Objective</h3><p>It was to adapt and analyze the Spanish adaptation of the Stanford Proxy Test for Delirium (S-PTD<em>sv</em>) instrument for its use among Spanish-speaking populations. The S-PTD is an instrument consisting of 13 observational items to be completed by a clinician observer, usually the patient's nurse. The completion of the questionnaire takes about 1 minute and does not require the active participation of the person evaluated, which has important clinical advantages compared to other available instruments (e.g., the Confusion Assessment Method).</p></div><div><h3>Methods</h3><p><span>The psychometric properties of the S-PTD</span><em>sv</em><span> were evaluated in a population of 123 patients using a quantitative, cross-sectional design. All subjects were over 18 years of age and hospitalized in various inpatient medico-surgical and intensive care unit services, either at the Barcelona Clinical Hospital (Barcelona, Spain) or the UC-Christus Health Network Clinical Hospital (Santiago, Chile, S.A.). The ultimate diagnosis of delirium was made by a member of the Psychiatry<span> Consult Service by means of an independent neuropsychiatric evaluation based on the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, published in 2013, which is the latest version of the diagnostic manual. All study tests were performed by study personnel who were blinded to each other's test results within an hour of each other.</span></span></p></div><div><h3>Results</h3><p>In the receiver operator characteristic (ROC) curve analysis, the S-PTD<em>sv</em> demonstrated excellent classification qualities when compared with the DSM-5 as the classification reference standard. Using a cutoff point of ≥3, the S-PTD<em>sv</em> had a sensitivity of 94% and a specificity of 97%. The area under the curve indicator was equal to 0.95, suggesting the S-PTD<em>sv</em> has an excellent overall performance in accurately identifying cases of delirium. Accordingly, the S-PTD<em>sv</em><span>'s positive predictive value = 0.93, and the negative predictive value = 0.97. The internal reliability measured with Cronbach's alpha was 0.96. Confirmatory factor analysis<span> revealed a 1-dimensional structure with high loadings (>0.72), demonstrating that all items similarly contribute to the total diagnostic dimension, suggesting adequate construct validity. T","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 2","pages":"Pages 136-147"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.10.002
Mark A. Oldham M.D. , Beth Heaney D.N.P., P.M.H.N.P. , Conrad Gleber M.D., M.B.A. , Hochang B. Lee M.D. , Daniel D. Maeng Ph.D.
Background
Manually screening for mental health needs in acute medical-surgical settings is thorough but time-intensive. Automated approaches to screening can enhance efficiency and reliability, but the predictive accuracy of automated screening remains largely unknown.
Objective
The aims of this project are to develop an automated screening list using discrete form data in the electronic medical record that identify medical inpatients with psychiatric needs and to evaluate its ability to predict the likelihood of psychiatric consultation.
Methods
An automated screening list was incorporated into an existing manual screening process for 1 year. Screening items were applied to the year's implementation data to determine whether they predicted consultation likelihood. Consultation likelihood was designated high, medium, or low. This prediction model was applied hospital-wide to characterize mental health needs.
Results
The screening items were derived from nursing screens, orders, and medication and diagnosis groupers. We excluded safety or suicide sitters from the model because all patients with sitters received psychiatric consultation. Area under the receiver operating characteristic curve for the regression model was 84%. The two most predictive items in the model were “3 or more psychiatric diagnoses” (odds ratio 15.7) and “prior suicide attempt” (odds ratio 4.7). The low likelihood category had a negative predictive value of 97.2%; the high likelihood category had a positive predictive value of 46.7%.
Conclusions
Electronic medical record discrete data elements predict the likelihood of psychiatric consultation. Automated approaches to screening deserve further investigation.
{"title":"Using Discrete Form Data in the Electronic Medical Record to Predict the Likelihood of Psychiatric Consultation","authors":"Mark A. Oldham M.D. , Beth Heaney D.N.P., P.M.H.N.P. , Conrad Gleber M.D., M.B.A. , Hochang B. Lee M.D. , Daniel D. Maeng Ph.D.","doi":"10.1016/j.jaclp.2023.10.002","DOIUrl":"10.1016/j.jaclp.2023.10.002","url":null,"abstract":"<div><h3>Background</h3><p>Manually screening for mental health needs in acute medical-surgical settings is thorough but time-intensive. Automated approaches to screening can enhance efficiency and reliability, but the predictive accuracy of automated screening remains largely unknown.</p></div><div><h3>Objective</h3><p>The aims of this project are to develop an automated screening list using discrete form data in the electronic medical record that identify medical inpatients with psychiatric needs and to evaluate its ability to predict the likelihood of psychiatric consultation.</p></div><div><h3>Methods</h3><p>An automated screening list was incorporated into an existing manual screening process for 1 year. Screening items were applied to the year's implementation data to determine whether they predicted consultation likelihood. Consultation likelihood was designated high, medium, or low. This prediction model was applied hospital-wide to characterize mental health needs.</p></div><div><h3>Results</h3><p>The screening items were derived from nursing screens, orders, and medication and diagnosis groupers. We excluded safety or suicide sitters from the model because all patients with sitters received psychiatric consultation. Area under the receiver operating characteristic curve for the regression model was 84%. The two most predictive items in the model were “3 or more psychiatric diagnoses” (odds ratio 15.7) and “prior suicide attempt” (odds ratio 4.7). The low likelihood category had a negative predictive value of 97.2%; the high likelihood category had a positive predictive value of 46.7%.</p></div><div><h3>Conclusions</h3><p>Electronic medical record discrete data elements predict the likelihood of psychiatric consultation. Automated approaches to screening deserve further investigation.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 25-32"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001325/pdfft?md5=2f1c6edb2e72af67e263014b7f52f22d&pid=1-s2.0-S2667296023001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.09.006
Jin Hong Park M.D., M.S. , Sheharyar Sarwar D.O. , Leslie C. Hassett M.L.S. , Jeffrey P. Staab M.D., M.S. , David C. Fipps D.O.
Background
Othello syndrome (OS) is a condition characterized by a delusion of jealousy that one's spouse is having extramarital affairs. As in the eponymous Shakespearean tragedy, there is an unfortunate risk of violence. For patients with these symptoms, consultation-liaison psychiatrists may be asked to assist with evaluating the differential diagnosis, assessing safety, and developing treatment options.
Objective
This study's objective was to solidify current knowledge of the clinical presentations and management of OS through a systematic review of the literature and description of 2 new cases.
Methods
We conducted a literature search from the start of relevant databases through August 2023 to identify English language case reports of adults (≥18 years) with OS that described clinical evaluations, biological treatments, and outcomes. We extracted demographics, proposed etiologies, treatment choices and responses, duration of delusions, comorbid psychiatric symptoms, neuro-radiographic findings, and presence of physical violence. We reported clinical findings for 2 new cases.
Results
Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we screened 705 abstracts and conducted full-text reviews of 118 articles to identify 73 cases published from 1983 to 2023 meeting inclusion criteria. The mean age was 58.2 years with male predominance (M:F = 1.88). Etiologies included primary psychiatric disorders (16, 22%), other medical conditions (38, 52%), and medications or other substances (19, 26%). Delusional disorder, cerebrovascular accident, and dopaminergic agonists were the most common etiologies, respectively, in these groups. Antipsychotics were the most common treatment (57, 78%). Symptom remission was reported in 51 (70%) cases. The average duration of OS was 39.5 months. Of 32 cases reporting brain imaging insults, 12 of 20 (60%) showed right-sided lesions, and 8 of 20 (40%) showed left-sided lesions, with 9 of 32 (28%) located in the frontal lobes. The most commonly co-existing psychiatric symptom was depression (14, 19%). Violence was reported in 25 cases (34%). Our 2 new cases were consistent with these findings.
Conclusions
OS may be a manifestation of several neuropsychiatric conditions, primarily delusional disorder, cerebrovascular accident, Alzheimer's dementia, and the use of dopaminergic agonists. One-third of cases include violent behaviors. It appears to respond to antipsychotic medications, but treatment is delayed more than 3 years on average. Available data have not localized OS to a specific brain region.
{"title":"Clinical Characterization, Course, and Treatment of Othello Syndrome: A Case Series and Systematic Review of the Literature","authors":"Jin Hong Park M.D., M.S. , Sheharyar Sarwar D.O. , Leslie C. Hassett M.L.S. , Jeffrey P. Staab M.D., M.S. , David C. Fipps D.O.","doi":"10.1016/j.jaclp.2023.09.006","DOIUrl":"10.1016/j.jaclp.2023.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Othello syndrome (OS) is a condition characterized by a delusion of jealousy that one's spouse is having extramarital affairs. As in the eponymous Shakespearean tragedy, there is an unfortunate risk of violence. For patients with these symptoms, consultation-liaison psychiatrists may be asked to assist with evaluating the differential diagnosis, assessing safety, and developing treatment options.</p></div><div><h3>Objective</h3><p>This study's objective was to solidify current knowledge of the clinical presentations and management of OS through a systematic review of the literature and description of 2 new cases.</p></div><div><h3>Methods</h3><p>We conducted a literature search from the start of relevant databases through August 2023 to identify English language case reports of adults (≥18 years) with OS that described clinical evaluations, biological treatments, and outcomes. We extracted demographics, proposed etiologies, treatment choices and responses, duration of delusions, comorbid psychiatric symptoms, neuro-radiographic findings, and presence of physical violence. We reported clinical findings for 2 new cases.</p></div><div><h3>Results</h3><p>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we screened 705 abstracts and conducted full-text reviews of 118 articles to identify 73 cases published from 1983 to 2023 meeting inclusion criteria. The mean age was 58.2 years with male predominance (M:F = 1.88). Etiologies included primary psychiatric disorders (16, 22%), other medical conditions (38, 52%), and medications or other substances (19, 26%). Delusional disorder, cerebrovascular accident, and dopaminergic agonists were the most common etiologies, respectively, in these groups. Antipsychotics were the most common treatment (57, 78%). Symptom remission was reported in 51 (70%) cases. The average duration of OS was 39.5 months. Of 32 cases reporting brain imaging insults, 12 of 20 (60%) showed right-sided lesions, and 8 of 20 (40%) showed left-sided lesions, with 9 of 32 (28%) located in the frontal lobes. The most commonly co-existing psychiatric symptom was depression (14, 19%). Violence was reported in 25 cases (34%). Our 2 new cases were consistent with these findings.</p></div><div><h3>Conclusions</h3><p>OS may be a manifestation of several neuropsychiatric conditions, primarily delusional disorder, cerebrovascular accident, Alzheimer's dementia, and the use of dopaminergic agonists. One-third of cases include violent behaviors. It appears to respond to antipsychotic medications, but treatment is delayed more than 3 years on average. Available data have not localized OS to a specific brain region.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 89-105"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001295/pdfft?md5=b7e5e1960c2873f260b814fe7565e25f&pid=1-s2.0-S2667296023001295-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to prospectively document the association between panic disorder (PD) or generalized anxiety disorder (GAD) and noncardiac chest pain (NCCP)-related disability. Its second objective was to validate an explanatory model of these associations.
Methods
This was a prospective cohort study of 124 emergency department patients with NCCP and comorbid PD or GAD. Anxiety sensitivity, heart-focused anxiety, and alexithymia were assessed at baseline. NCCP-related disability was assessed at baseline and at the 6-month follow-up. Mediation analysis was used to validate the explanatory model.
Results
The rate of NCCP-related disability was 54.8% (n = 68) at baseline and 34.7% (n = 43) at the 6-month follow-up. Patients with PD were significantly more likely to report NCCP-related disability at the 6-month follow-up than those with GAD alone (P = 0.021). A simplified model containing a causal chain between anxiety, anxiety sensitivity, heart-focused anxiety, and NCCP-related disability at the 6-month follow-up was a good fit for the data.
Conclusions
PD appears to be more closely associated with NCCP-related disability than GAD. Among patients with NCCP and comorbid PD or GAD, heart-focused anxiety was the main psychological determinant of the development or maintenance of NCCP-related disability in the 6 months following an emergency department visit.
{"title":"A Prospective Study of Noncardiac Chest Pain-Related Disability in Emergency Department Patients With Comorbid Anxiety Disorders","authors":"Stéphanie Hamel Ph.D. , Isabelle Denis Psy.D., Ph.D. , Stéphane Turcotte M.Sc. , Richard Fleet M.D., Ph.D. , Patrick Archambault M.D. , Clermont E. Dionne Ph.D. , Guillaume Foldes-Busque Psy.D., Ph.D.","doi":"10.1016/j.jaclp.2023.04.007","DOIUrl":"10.1016/j.jaclp.2023.04.007","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to prospectively document the association between panic disorder (PD) or generalized anxiety disorder (GAD) and noncardiac chest pain (NCCP)-related disability. Its second objective was to validate an explanatory model of these associations.</p></div><div><h3>Methods</h3><p>This was a prospective cohort study of 124 emergency department patients with NCCP and comorbid PD or GAD. Anxiety sensitivity, heart-focused anxiety, and alexithymia were assessed at baseline. NCCP-related disability was assessed at baseline and at the 6-month follow-up. Mediation analysis was used to validate the explanatory model.</p></div><div><h3>Results</h3><p>The rate of NCCP-related disability was 54.8% (<em>n</em> = 68) at baseline and 34.7% (<em>n</em> = 43) at the 6-month follow-up. Patients with PD were significantly more likely to report NCCP-related disability at the 6-month follow-up than those with GAD alone (<em>P</em> = 0.021). A simplified model containing a causal chain between anxiety, anxiety sensitivity, heart-focused anxiety, and NCCP-related disability at the 6-month follow-up was a good fit for the data.</p></div><div><h3>Conclusions</h3><p>PD appears to be more closely associated with NCCP-related disability than GAD. Among patients with NCCP and comorbid PD or GAD, heart-focused anxiety was the main psychological determinant of the development or maintenance of NCCP-related disability in the 6 months following an emergency department visit.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 4-13"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023000824/pdfft?md5=71cca7973f4826ffcaa61cd97643e5a2&pid=1-s2.0-S2667296023000824-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83965548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.09.007
Bilal A. Bari M.D., Ph.D., Scott R. Beach M.D.
{"title":"Evaluating Capacity: Appelbaum's Framework Interpreted Diagrammatically","authors":"Bilal A. Bari M.D., Ph.D., Scott R. Beach M.D.","doi":"10.1016/j.jaclp.2023.09.007","DOIUrl":"10.1016/j.jaclp.2023.09.007","url":null,"abstract":"","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 120-121"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001301/pdfft?md5=74c0f3bca35f9e9100ab6192e55274c8&pid=1-s2.0-S2667296023001301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.08.004
Harish S. Pudukodu M.D., Varsha Radhakrishnan M.D., Jordan H. Rosen M.D.
{"title":"Polypharmacologic Toxicity Involving Deutetrabenazine in a Patient With Renal Insufficiency","authors":"Harish S. Pudukodu M.D., Varsha Radhakrishnan M.D., Jordan H. Rosen M.D.","doi":"10.1016/j.jaclp.2023.08.004","DOIUrl":"10.1016/j.jaclp.2023.08.004","url":null,"abstract":"","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 116-117"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001118/pdfft?md5=2abfd1768b687271e3e59601008732cf&pid=1-s2.0-S2667296023001118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10334813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.10.005
Natalia Kosyakova B.S. , Jacob S. Shaw B.S. , Anne Reisch M.D. , Lisa N. Richey B.A , Sabrina Kentis B.A , Barry R. Bryant M.D. , Aaron I. Esagoff B.S. , Jacob White M.L.S. , Matthew E. Peters M.D.
Background
There is limited characterization of neuropsychiatric symptoms (NPS) in patients with idiopathic intracranial hypertension (IIH). Along with commonly presenting symptoms of IIH, including headache and papilledema, NPS may have a significant impact on IIH outcomes.
Objective
We completed a systematic review of the literature to characterize the most common noncognitive NPS in IIH patients and examine associations between noncognitive NPS and IIH outcomes.
Methods
A Preferred Reporting Items for Systemic Reviews and Meta-Analysis compliant literature search was conducted in Ovid Medline, PubMed, PsycInfo, Embase, Web of Science, Cochrane, CINAHL, and Scopus databases. The initial query yielded 1688 unique articles. These articles were narrowed to those including empirical analyses of noncognitive NPS in adult patients with IIH.
Results
A final cohort of eight articles comprised 724 individuals with IIH and 257 healthy controls. Noncognitive NPS, specifically anxiety and depression, were more common in IIH patients compared to controls. Patients with IIH also reported increased headache, visual disturbances, and overall poorer quality of life. Limitations included heterogeneous sample characteristics along with variability in measurement of noncognitive NPS between studies.
Conclusions
A greater understanding of the most prevalent noncognitive NPS such as depression and anxiety in IIH patients, particularly among females who are obese and facing social and economic marginalization, may help to reduce IIH-associated morbidity. In particular, improved screening and timely management of psychiatric conditions using a multidisciplinary approach may improve IIH outcomes.
{"title":"A Systematic Review of Neuropsychiatric Symptoms in Idiopathic Intracranial Hypertension","authors":"Natalia Kosyakova B.S. , Jacob S. Shaw B.S. , Anne Reisch M.D. , Lisa N. Richey B.A , Sabrina Kentis B.A , Barry R. Bryant M.D. , Aaron I. Esagoff B.S. , Jacob White M.L.S. , Matthew E. Peters M.D.","doi":"10.1016/j.jaclp.2023.10.005","DOIUrl":"10.1016/j.jaclp.2023.10.005","url":null,"abstract":"<div><h3>Background</h3><p>There is limited characterization of neuropsychiatric symptoms (NPS) in patients with idiopathic intracranial hypertension (IIH). Along with commonly presenting symptoms of IIH, including headache and papilledema, NPS may have a significant impact on IIH outcomes.</p></div><div><h3>Objective</h3><p>We completed a systematic review of the literature to characterize the most common noncognitive NPS in IIH patients and examine associations between noncognitive NPS and IIH outcomes.</p></div><div><h3>Methods</h3><p>A Preferred Reporting Items for Systemic Reviews and Meta-Analysis compliant literature search was conducted in Ovid Medline, PubMed, PsycInfo, Embase, Web of Science, Cochrane, CINAHL, and Scopus databases. The initial query yielded 1688 unique articles. These articles were narrowed to those including empirical analyses of noncognitive NPS in adult patients with IIH.</p></div><div><h3>Results</h3><p>A final cohort of eight articles comprised 724 individuals with IIH and 257 healthy controls. Noncognitive NPS, specifically anxiety and depression, were more common in IIH patients compared to controls. Patients with IIH also reported increased headache, visual disturbances, and overall poorer quality of life. Limitations included heterogeneous sample characteristics along with variability in measurement of noncognitive NPS between studies.</p></div><div><h3>Conclusions</h3><p>A greater understanding of the most prevalent noncognitive NPS such as depression and anxiety in IIH patients, particularly among females who are obese and facing social and economic marginalization, may help to reduce IIH-associated morbidity. In particular, improved screening and timely management of psychiatric conditions using a multidisciplinary approach may improve IIH outcomes.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 39-53"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001350/pdfft?md5=2fec9ec22201a2d26c4fd3dc9b06addc&pid=1-s2.0-S2667296023001350-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.jaclp.2023.08.006
Tuna Hasoglu M.D., Brian J. Lee M.D., Ph.D., Irving M. Reti M.B.B.S.
{"title":"Repeated Cerebellar Symptoms Post-ECT in a Geriatric Patient","authors":"Tuna Hasoglu M.D., Brian J. Lee M.D., Ph.D., Irving M. Reti M.B.B.S.","doi":"10.1016/j.jaclp.2023.08.006","DOIUrl":"10.1016/j.jaclp.2023.08.006","url":null,"abstract":"","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 118-119"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001234/pdfft?md5=9704151ba9bceb3d042e3f16af241ed0&pid=1-s2.0-S2667296023001234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}