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Intravenous Ketamine Exacerbating Symptoms of Acute Stress Disorder: A Case Report and Systematized Review of Existing Literature 静脉注射氯胺酮加重急性应激障碍的症状:一例报告和现有文献的系统回顾。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1016/j.jaclp.2023.11.687
Charalambia Louka M.D., Stephanie Chiao M.D.

Background

Ketamine is an anesthetic and analgesic known for its psychotomimetic properties, such as dissociation and altered perception. Acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) are characterized by unwanted memories, intrusive thoughts, and dissociative flashbacks following an acute traumatic event. It is unknown how analgesic ketamine affects the symptomatology of ASD when administered to patients in the posttraumatic period.

Objective and Methods

In this article, we present the case of a 26-year-old man who sustained gunshot wounds and developed worsened ASD after receiving analgesic ketamine. We also present a review of the current literature on peritraumatic ketamine and its subsequent effect on ASD and PTSD.

Results

In 2 out of 3 articles examining ketamine and ASD, ketamine was associated with worsened symptomatology of ASD. There were 6 articles examining ketamine and PTSD. In 1 of 6 articles, ketamine was associated with increased incidence and/or severity of PTSD, and in 2 of 6, it was associated with decreased incidence and/or severity of PTSD. There was no relationship between ketamine and subsequent PTSD in 3 of 6 articles.

Conclusion

We conclude that ketamine's psychotomimetic properties may exacerbate the dissociative and perceptual symptoms of ASD, but its long-term effects on PTSD are still unclear. In patients with preexisting ASD, the potential risks and benefits of using analgesic ketamine must be weighed carefully.

背景:氯胺酮是一种麻醉药和镇痛药,以其拟精神特性而闻名,如解离和知觉改变。急性应激障碍(ASD)和创伤后应激障碍(PTSD)的特征是在急性创伤事件后出现不想要的记忆、侵入性思想和分离性闪回。目前尚不清楚在创伤后时期给药氯胺酮如何影响ASD的症状学。目的与方法:在本文中,我们报告了一名26岁的男性,他在接受止痛药氯胺酮后持续枪伤并发展为恶化的ASD。我们也对目前关于创伤后氯胺酮及其对ASD和PTSD的影响的文献进行了综述。结果:在3篇研究氯胺酮与ASD的文章中,有2篇文章发现氯胺酮与ASD症状恶化有关。有6篇文章研究氯胺酮和创伤后应激障碍。在6篇文章中有1篇,氯胺酮与PTSD发病率和/或严重程度的增加有关,在6篇文章中有2篇,氯胺酮与PTSD发病率和/或严重程度的降低有关。6篇文章中有3篇没有氯胺酮和后续创伤后应激障碍之间的关系。结论:氯胺酮的拟精神特性可能会加重ASD的解离性和知觉症状,但其对PTSD的长期影响尚不清楚。对于已经存在ASD的患者,使用止痛剂氯胺酮的潜在风险和益处必须仔细权衡。
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引用次数: 0
Chronic Pain, Hopelessness, and Suicide Risk Among Adult Medical Inpatients 慢性疼痛、绝望与成人住院病人自杀风险
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1016/j.jaclp.2023.11.686
Patrick C. Ryan B.A. , Nathan J. Lowry B.A. , Edwin Boudreaux Ph.D. , Deborah J. Snyder M.S.W., L.C.S.W.-C. , Cynthia A. Claassen M.D. , Colin J. Harrington M.D. , David A. Jobes Ph.D. , Jeffrey A. Bridge Ph.D. , Maryland Pao M.D. , Lisa M. Horowitz Ph.D., M.P.H.

Background

Medically ill adults are at elevated risk for suicide. Chronic pain and hopelessness are associated with suicide; however, few studies have examined the interaction between chronic pain and hopelessness in predicting suicide risk among hospitalized adults.

Objective

This study aimed to describe the association between chronic pain, hopelessness, and suicide risk, defined as recent suicidal ideation or lifetime suicidal behavior. In addition, we examined the interaction between chronic pain and hopelessness.

Methods

This was a secondary analysis of a multisite study to validate the Ask Suicide-Screening Questions (ASQ) among adult medical inpatients. Participants reported if they experienced chronic pain that impacted daily life and if they felt hopeless about their medical condition and provided their current pain rating on a 1 to 10 scale, with 10 being the most severe pain. A t-test compared pain severity scores by ASQ outcome. A binary logistic regression model described the association between chronic pain, hopelessness, and suicide risk; parameter estimates are expressed as odds ratios (OR) for interpretation. The interaction between chronic pain and hopelessness was examined in both the transformed (logit) and natural (probability) scales of the generalized linear model.

Results

The sample included 720 participants (53.2% male, 62.4% White, mean age: 50.1 [16.3] years, range = 18–93). On the ASQ, 15.7% (113/720) of patients screened positive. Half (360/720) of the sample self-reported chronic pain. Individuals who screened positive had higher pain rating scores than those who screened negative (t = −4.2, df = 147.6, P < 0.001). Among all patients, 27.2% (196/720) felt hopeless about their medical condition. In the logistic regression model, patients with chronic pain (adjusted OR: 2.29, 95% confidence interval [CI]: 1.21–4.43, P = 0.01) or hopelessness (adjusted OR: 5.69, 95% CI: 2.52–12.64, P < 0.001) had greater odds of screening positive on the ASQ. The interaction effect between pain and hopelessness was not significant in the transformed (B = −0.15, 95% CI: −1.11 to 0.82, P = 0.76) or natural (B = 0.08, 95% CI: −0.07 to 0.23, P = 0.28) scale.

Conclusions

There were significant independent associations between (1) chronic pain and suicide risk and between (2) hopelessness and suicide risk. Future research should examine the temporality and mechanisms underlying these relationships to inform prevention efforts for medically ill adults.

背景:患有医学疾病的成年人自杀的风险较高。慢性疼痛和绝望与自杀有关;然而,很少有研究调查慢性疼痛和无望在预测住院成年人自杀风险方面的相互作用。目的:本研究旨在描述慢性疼痛、绝望和自杀风险之间的关系,自杀风险定义为近期自杀意念或终生自杀行为。此外,我们还研究了慢性疼痛和绝望之间的相互作用。方法:这是一项多地点研究的二次分析,以验证在成年住院患者中询问自杀筛查问题(ASQ)。参与者报告了他们是否经历过影响日常生活的慢性疼痛,是否对自己的身体状况感到绝望,并提供了他们目前的疼痛等级,等级为1-10,其中10代表最严重的疼痛。用t检验比较疼痛严重程度评分和ASQ结果。一个二元逻辑回归模型描述了慢性疼痛、绝望和自杀风险之间的关系;参数估计用比值比(OR)表示,以便解释。在广义线性模型的转换(logit)和自然(概率)尺度中检查了慢性疼痛和绝望之间的相互作用。结果:共纳入受试者720人,其中男性53.2%,白人62.4%,平均年龄50.1[16.3]岁,年龄范围18-93岁。在ASQ上,15.7(113/720)例患者筛查呈阳性。一半(360/720)的样本自我报告慢性疼痛。结论:慢性疼痛与自杀风险、绝望感与自杀风险之间存在显著的独立关联(t=-4.2, df=147.6)。未来的研究应该检查这些关系的暂时性和机制,以便为患病成人的预防工作提供信息。
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引用次数: 0
Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in Two Clinical Spanish-Speaking Communities 斯坦福Delirium代理测试(S-PTDsv)在两个西班牙语临床社区的西班牙语适应性的可靠性和有效性。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1016/j.jaclp.2023.09.004
Sanndy Infante M.Sc. , Alex Behn Ph.D. , Matías González Ph.D. , Luis Pintor Ph.D. , Eduardo Franco Ph.D. , Pablo Araya M.D. , José R. Maldonado Ph.D.
<div><h3>Background</h3><p>Delirium is the most prevalent neuropsychiatric syndrome experienced by patients admitted to inpatient clinical units, occurring in at least 20% of medically hospitalized patients and up to 85% of those admitted to critical care units. Although current guidelines recommend the implementation of universal prevention strategies, the use of management strategies largely depends on constant surveillance and screening. This allows for the timely diagnosis and correction of its underlying causes and implementation of management strategies.</p></div><div><h3>Objective</h3><p>It was to adapt and analyze the Spanish adaptation of the Stanford Proxy Test for Delirium (S-PTD<em>sv</em>) instrument for its use among Spanish-speaking populations. The S-PTD is an instrument consisting of 13 observational items to be completed by a clinician observer, usually the patient's nurse. The completion of the questionnaire takes about 1 minute and does not require the active participation of the person evaluated, which has important clinical advantages compared to other available instruments (e.g., the Confusion Assessment Method).</p></div><div><h3>Methods</h3><p><span>The psychometric properties of the S-PTD</span><em>sv</em><span> were evaluated in a population of 123 patients using a quantitative, cross-sectional design. All subjects were over 18 years of age and hospitalized in various inpatient medico-surgical and intensive care unit services, either at the Barcelona Clinical Hospital (Barcelona, Spain) or the UC-Christus Health Network Clinical Hospital (Santiago, Chile, S.A.). The ultimate diagnosis of delirium was made by a member of the Psychiatry<span> Consult Service by means of an independent neuropsychiatric evaluation based on the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, published in 2013, which is the latest version of the diagnostic manual. All study tests were performed by study personnel who were blinded to each other's test results within an hour of each other.</span></span></p></div><div><h3>Results</h3><p>In the receiver operator characteristic (ROC) curve analysis, the S-PTD<em>sv</em> demonstrated excellent classification qualities when compared with the DSM-5 as the classification reference standard. Using a cutoff point of ≥3, the S-PTD<em>sv</em> had a sensitivity of 94% and a specificity of 97%. The area under the curve indicator was equal to 0.95, suggesting the S-PTD<em>sv</em> has an excellent overall performance in accurately identifying cases of delirium. Accordingly, the S-PTD<em>sv</em><span>'s positive predictive value = 0.93, and the negative predictive value = 0.97. The internal reliability measured with Cronbach's alpha was 0.96. Confirmatory factor analysis<span> revealed a 1-dimensional structure with high loadings (>0.72), demonstrating that all items similarly contribute to the total diagnostic dimension, suggesting adequate construct validity. T
背景:谵妄是住院临床病房患者经历的最常见的神经精神综合征,至少20%的住院患者和85%的重症监护病房患者都会出现谵妄。尽管目前的指导方针建议实施普遍预防战略,但管理战略的使用在很大程度上取决于持续的监测和筛查。这使得能够及时诊断和纠正其根本原因,并实施管理战略。目的:为了在西班牙语人群中使用,对斯坦福Delirium代理测试(S-PTDsv)仪器的西班牙语适应性进行调整和分析。S-PTD是一种由13个观察项目组成的仪器,由临床医生观察员(通常是患者的护士)完成。问卷的完成大约需要一分钟,不需要被评估者的积极参与,与其他可用的工具(如困惑评估方法[CAM])相比,这具有重要的临床优势,横截面设计。所有受试者均超过18岁,在巴塞罗那临床医院(西班牙巴塞罗那)或UC-Christus健康网络临床医院(智利圣地亚哥,美国)的各种住院医疗外科和重症监护室服务中住院,通过基于2013年出版的《精神障碍诊断与统计手册》(DSM-5)第5版标准的独立神经精神评估,这是该诊断手册的最新版本。所有研究测试都是由研究人员进行的,他们对彼此的测试结果视而不见,并且在一小时内完成。结果:在ROC分析中,与作为分类金标准的DSM-5相比,S-PTDsv表现出优异的分类质量。当临界点≥3时,S-PTDsv的敏感性为94%,特异性为97%。AUC指标等于0.95,表明S-PTDsv在准确识别谵妄病例方面具有出色的整体性能。因此,S-PTDsv的阳性预测值(PPV)=0.93,阴性预测值(NPV)=0.97。用Cronbach’s Alpha测量的内部可靠性为0.96。验证性因素分析揭示了高负荷(>0.72)的一维结构,表明所有项目对总诊断维度的贡献相似,表明有足够的结构有效性。这提供了趋同有效性的证据。结论:与基于DSM-5的盲法神经精神评估相比,S-PTDsv的性能表明,它是在西班牙语人群中检测谵妄的有效工具。这些结果与之前发表的英文版研究结果具有可比性和一致性。
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引用次数: 0
Using Discrete Form Data in the Electronic Medical Record to Predict the Likelihood of Psychiatric Consultation 使用电子病历中的离散形式数据来预测精神科会诊的可能性。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.10.002
Mark A. Oldham M.D. , Beth Heaney D.N.P., P.M.H.N.P. , Conrad Gleber M.D., M.B.A. , Hochang B. Lee M.D. , Daniel D. Maeng Ph.D.

Background

Manually screening for mental health needs in acute medical-surgical settings is thorough but time-intensive. Automated approaches to screening can enhance efficiency and reliability, but the predictive accuracy of automated screening remains largely unknown.

Objective

The aims of this project are to develop an automated screening list using discrete form data in the electronic medical record that identify medical inpatients with psychiatric needs and to evaluate its ability to predict the likelihood of psychiatric consultation.

Methods

An automated screening list was incorporated into an existing manual screening process for 1 year. Screening items were applied to the year's implementation data to determine whether they predicted consultation likelihood. Consultation likelihood was designated high, medium, or low. This prediction model was applied hospital-wide to characterize mental health needs.

Results

The screening items were derived from nursing screens, orders, and medication and diagnosis groupers. We excluded safety or suicide sitters from the model because all patients with sitters received psychiatric consultation. Area under the receiver operating characteristic curve for the regression model was 84%. The two most predictive items in the model were “3 or more psychiatric diagnoses” (odds ratio 15.7) and “prior suicide attempt” (odds ratio 4.7). The low likelihood category had a negative predictive value of 97.2%; the high likelihood category had a positive predictive value of 46.7%.

Conclusions

Electronic medical record discrete data elements predict the likelihood of psychiatric consultation. Automated approaches to screening deserve further investigation.

目的:该项目的目的是利用电子病历(EMR)中的离散形式数据开发一个自动筛查列表,以识别有精神需求的住院患者,并评估其预测精神咨询可能性的能力。方法:将自动筛选列表纳入现有的手动筛选过程中,为期一年。将筛选项目应用于当年的实施数据,以确定它们是否预测了咨询的可能性。会诊可能性被指定为高、中或低。该预测模型在医院范围内应用,以表征心理健康需求。结果:筛查项目来源于护理筛查、医嘱、药物和诊断分组。我们将安全保姆或自杀保姆排除在模型之外,因为所有有保姆的患者都接受了心理咨询。回归模型的受试者工作特性曲线下的面积为84%。模型中最具预测性的两个项目是“3次或3次以上精神病诊断”(or 15.7)和“既往自杀未遂”(or 4.7)。低可能性类别的阴性预测值为97.2%;高可能性类别的阳性预测值为46.7%。结论:EMR离散数据元素可预测精神科会诊的可能性。自动化筛查方法值得进一步研究。
{"title":"Using Discrete Form Data in the Electronic Medical Record to Predict the Likelihood of Psychiatric Consultation","authors":"Mark A. Oldham M.D. ,&nbsp;Beth Heaney D.N.P., P.M.H.N.P. ,&nbsp;Conrad Gleber M.D., M.B.A. ,&nbsp;Hochang B. Lee M.D. ,&nbsp;Daniel D. Maeng Ph.D.","doi":"10.1016/j.jaclp.2023.10.002","DOIUrl":"10.1016/j.jaclp.2023.10.002","url":null,"abstract":"<div><h3>Background</h3><p>Manually screening for mental health needs in acute medical-surgical settings is thorough but time-intensive. Automated approaches to screening can enhance efficiency and reliability, but the predictive accuracy of automated screening remains largely unknown.</p></div><div><h3>Objective</h3><p>The aims of this project are to develop an automated screening list using discrete form data in the electronic medical record that identify medical inpatients with psychiatric needs and to evaluate its ability to predict the likelihood of psychiatric consultation.</p></div><div><h3>Methods</h3><p>An automated screening list was incorporated into an existing manual screening process for 1 year. Screening items were applied to the year's implementation data to determine whether they predicted consultation likelihood. Consultation likelihood was designated high, medium, or low. This prediction model was applied hospital-wide to characterize mental health needs.</p></div><div><h3>Results</h3><p>The screening items were derived from nursing screens, orders, and medication and diagnosis groupers. We excluded safety or suicide sitters from the model because all patients with sitters received psychiatric consultation. Area under the receiver operating characteristic curve for the regression model was 84%. The two most predictive items in the model were “3 or more psychiatric diagnoses” (odds ratio 15.7) and “prior suicide attempt” (odds ratio 4.7). The low likelihood category had a negative predictive value of 97.2%; the high likelihood category had a positive predictive value of 46.7%.</p></div><div><h3>Conclusions</h3><p>Electronic medical record discrete data elements predict the likelihood of psychiatric consultation. Automated approaches to screening deserve further investigation.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 25-32"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001325/pdfft?md5=2f1c6edb2e72af67e263014b7f52f22d&pid=1-s2.0-S2667296023001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characterization, Course, and Treatment of Othello Syndrome: A Case Series and Systematic Review of the Literature 奥赛罗综合征的临床特点、病程和治疗:病例系列和文献系统综述。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.09.006
Jin Hong Park M.D., M.S. , Sheharyar Sarwar D.O. , Leslie C. Hassett M.L.S. , Jeffrey P. Staab M.D., M.S. , David C. Fipps D.O.

Background

Othello syndrome (OS) is a condition characterized by a delusion of jealousy that one's spouse is having extramarital affairs. As in the eponymous Shakespearean tragedy, there is an unfortunate risk of violence. For patients with these symptoms, consultation-liaison psychiatrists may be asked to assist with evaluating the differential diagnosis, assessing safety, and developing treatment options.

Objective

This study's objective was to solidify current knowledge of the clinical presentations and management of OS through a systematic review of the literature and description of 2 new cases.

Methods

We conducted a literature search from the start of relevant databases through August 2023 to identify English language case reports of adults (≥18 years) with OS that described clinical evaluations, biological treatments, and outcomes. We extracted demographics, proposed etiologies, treatment choices and responses, duration of delusions, comorbid psychiatric symptoms, neuro-radiographic findings, and presence of physical violence. We reported clinical findings for 2 new cases.

Results

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we screened 705 abstracts and conducted full-text reviews of 118 articles to identify 73 cases published from 1983 to 2023 meeting inclusion criteria. The mean age was 58.2 years with male predominance (M:F = 1.88). Etiologies included primary psychiatric disorders (16, 22%), other medical conditions (38, 52%), and medications or other substances (19, 26%). Delusional disorder, cerebrovascular accident, and dopaminergic agonists were the most common etiologies, respectively, in these groups. Antipsychotics were the most common treatment (57, 78%). Symptom remission was reported in 51 (70%) cases. The average duration of OS was 39.5 months. Of 32 cases reporting brain imaging insults, 12 of 20 (60%) showed right-sided lesions, and 8 of 20 (40%) showed left-sided lesions, with 9 of 32 (28%) located in the frontal lobes. The most commonly co-existing psychiatric symptom was depression (14, 19%). Violence was reported in 25 cases (34%). Our 2 new cases were consistent with these findings.

Conclusions

OS may be a manifestation of several neuropsychiatric conditions, primarily delusional disorder, cerebrovascular accident, Alzheimer's dementia, and the use of dopaminergic agonists. One-third of cases include violent behaviors. It appears to respond to antipsychotic medications, but treatment is delayed more than 3 years on average. Available data have not localized OS to a specific brain region.

背景:奥赛罗综合征(OS)是一种以嫉妒妄想为特征的疾病,认为配偶有婚外情。正如莎士比亚的悲剧一样,存在着不幸的暴力风险。对于有这些症状的患者,可能会要求咨询联络精神科医生协助评估鉴别诊断、评估安全性和制定治疗方案。目的:本研究的目的是通过对文献的系统回顾和对两例新病例的描述,巩固目前对OS临床表现和管理的认识。方法:我们从相关数据库开始到2023年8月进行了文献检索,以确定患有OS的成年人(≥18岁)的英语病例报告,这些报告描述了临床评估、生物治疗和结果。我们提取了人口统计数据、提出的病因、治疗选择和反应、妄想的持续时间、共病精神症状、神经放射学检查结果和身体暴力的存在。我们报告了两例新病例的临床发现。结果:根据PRISMA指南,我们筛选了705篇摘要,并对118篇文章进行了全文综述,以确定1983-2023年发表的73例符合纳入标准的病例。平均年龄58.2岁,男性占主导地位(M:F=1.88)。病因包括原发性精神疾病(16.22%)、其他疾病(38.52%)和药物或其他物质(19.26%)。妄想障碍、脑血管意外和多巴胺能激动剂分别是这些组中最常见的病因。抗精神病药物是最常见的治疗方法(57.78%)。症状缓解51例(70%)。OS的平均持续时间为39.5个月。在32例报告脑成像损伤的病例中,12/20(60%)显示右侧病变,8/20(40%)显示左侧病变,9/32(28%)位于额叶。同时存在的最常见的精神症状是抑郁症(14.19%)。据报告,发生了25起暴力事件(34%)。我们的两个新病例与这些发现一致。结论:OS可能是几种神经精神疾病的表现,主要是妄想症、脑血管意外、阿尔茨海默氏症和多巴胺能激动剂的使用。三分之一的案件包括暴力行为。它似乎对抗精神病药物有反应,但治疗平均延迟3年以上。现有数据尚未将OS定位到特定的大脑区域。
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引用次数: 0
A Prospective Study of Noncardiac Chest Pain-Related Disability in Emergency Department Patients With Comorbid Anxiety Disorders 急诊科合并焦虑症患者非心源性胸痛相关残疾的前瞻性研究
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.04.007
Stéphanie Hamel Ph.D. , Isabelle Denis Psy.D., Ph.D. , Stéphane Turcotte M.Sc. , Richard Fleet M.D., Ph.D. , Patrick Archambault M.D. , Clermont E. Dionne Ph.D. , Guillaume Foldes-Busque Psy.D., Ph.D.

Objective

This study aimed to prospectively document the association between panic disorder (PD) or generalized anxiety disorder (GAD) and noncardiac chest pain (NCCP)-related disability. Its second objective was to validate an explanatory model of these associations.

Methods

This was a prospective cohort study of 124 emergency department patients with NCCP and comorbid PD or GAD. Anxiety sensitivity, heart-focused anxiety, and alexithymia were assessed at baseline. NCCP-related disability was assessed at baseline and at the 6-month follow-up. Mediation analysis was used to validate the explanatory model.

Results

The rate of NCCP-related disability was 54.8% (n = 68) at baseline and 34.7% (n = 43) at the 6-month follow-up. Patients with PD were significantly more likely to report NCCP-related disability at the 6-month follow-up than those with GAD alone (P = 0.021). A simplified model containing a causal chain between anxiety, anxiety sensitivity, heart-focused anxiety, and NCCP-related disability at the 6-month follow-up was a good fit for the data.

Conclusions

PD appears to be more closely associated with NCCP-related disability than GAD. Among patients with NCCP and comorbid PD or GAD, heart-focused anxiety was the main psychological determinant of the development or maintenance of NCCP-related disability in the 6 months following an emergency department visit.

本研究旨在前瞻性地记录惊恐障碍 (PD) 或广泛性焦虑症 (GAD) 与非心源性胸痛 (NCCP) 相关残疾之间的关系。方法这是一项前瞻性队列研究,研究对象是 124 名患有非心源性胸痛并合并有 PD 或 GAD 的急诊科患者。基线评估包括焦虑敏感性、心焦虑和自闭症。在基线和 6 个月随访时对 NCCP 相关残疾进行评估。结果基线时NCCP相关残疾率为54.8%(68人),随访6个月时为34.7%(43人)。在 6 个月的随访中,PD 患者报告 NCCP 相关残疾的可能性明显高于单纯 GAD 患者(P = 0.021)。一个包含焦虑、焦虑敏感性、心焦虑和 6 个月随访时 NCCP 相关残疾之间因果关系链的简化模型很好地拟合了数据。在患有 NCCP 并合并 PD 或 GAD 的患者中,心脏焦虑是急诊就诊后 6 个月内 NCCP 相关残疾发生或维持的主要心理决定因素。
{"title":"A Prospective Study of Noncardiac Chest Pain-Related Disability in Emergency Department Patients With Comorbid Anxiety Disorders","authors":"Stéphanie Hamel Ph.D. ,&nbsp;Isabelle Denis Psy.D., Ph.D. ,&nbsp;Stéphane Turcotte M.Sc. ,&nbsp;Richard Fleet M.D., Ph.D. ,&nbsp;Patrick Archambault M.D. ,&nbsp;Clermont E. Dionne Ph.D. ,&nbsp;Guillaume Foldes-Busque Psy.D., Ph.D.","doi":"10.1016/j.jaclp.2023.04.007","DOIUrl":"10.1016/j.jaclp.2023.04.007","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to prospectively document the association between panic disorder (PD) or generalized anxiety disorder (GAD) and noncardiac chest pain (NCCP)-related disability. Its second objective was to validate an explanatory model of these associations.</p></div><div><h3>Methods</h3><p>This was a prospective cohort study of 124 emergency department patients with NCCP and comorbid PD or GAD. Anxiety sensitivity, heart-focused anxiety, and alexithymia were assessed at baseline. NCCP-related disability was assessed at baseline and at the 6-month follow-up. Mediation analysis was used to validate the explanatory model.</p></div><div><h3>Results</h3><p>The rate of NCCP-related disability was 54.8% (<em>n</em> = 68) at baseline and 34.7% (<em>n</em> = 43) at the 6-month follow-up. Patients with PD were significantly more likely to report NCCP-related disability at the 6-month follow-up than those with GAD alone (<em>P</em> = 0.021). A simplified model containing a causal chain between anxiety, anxiety sensitivity, heart-focused anxiety, and NCCP-related disability at the 6-month follow-up was a good fit for the data.</p></div><div><h3>Conclusions</h3><p>PD appears to be more closely associated with NCCP-related disability than GAD. Among patients with NCCP and comorbid PD or GAD, heart-focused anxiety was the main psychological determinant of the development or maintenance of NCCP-related disability in the 6 months following an emergency department visit.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 4-13"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023000824/pdfft?md5=71cca7973f4826ffcaa61cd97643e5a2&pid=1-s2.0-S2667296023000824-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83965548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Capacity: Appelbaum's Framework Interpreted Diagrammatically 评估能力:对Appelbaum的框架进行图解解释。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.09.007
Bilal A. Bari M.D., Ph.D., Scott R. Beach M.D.
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引用次数: 0
Polypharmacologic Toxicity Involving Deutetrabenazine in a Patient With Renal Insufficiency 一名肾功能不全患者的丁胺苯丙肼多药毒性反应
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.08.004
Harish S. Pudukodu M.D., Varsha Radhakrishnan M.D., Jordan H. Rosen M.D.
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引用次数: 0
A Systematic Review of Neuropsychiatric Symptoms in Idiopathic Intracranial Hypertension 特发性颅内高压症神经精神症状系统综述
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.10.005
Natalia Kosyakova B.S. , Jacob S. Shaw B.S. , Anne Reisch M.D. , Lisa N. Richey B.A , Sabrina Kentis B.A , Barry R. Bryant M.D. , Aaron I. Esagoff B.S. , Jacob White M.L.S. , Matthew E. Peters M.D.

Background

There is limited characterization of neuropsychiatric symptoms (NPS) in patients with idiopathic intracranial hypertension (IIH). Along with commonly presenting symptoms of IIH, including headache and papilledema, NPS may have a significant impact on IIH outcomes.

Objective

We completed a systematic review of the literature to characterize the most common noncognitive NPS in IIH patients and examine associations between noncognitive NPS and IIH outcomes.

Methods

A Preferred Reporting Items for Systemic Reviews and Meta-Analysis compliant literature search was conducted in Ovid Medline, PubMed, PsycInfo, Embase, Web of Science, Cochrane, CINAHL, and Scopus databases. The initial query yielded 1688 unique articles. These articles were narrowed to those including empirical analyses of noncognitive NPS in adult patients with IIH.

Results

A final cohort of eight articles comprised 724 individuals with IIH and 257 healthy controls. Noncognitive NPS, specifically anxiety and depression, were more common in IIH patients compared to controls. Patients with IIH also reported increased headache, visual disturbances, and overall poorer quality of life. Limitations included heterogeneous sample characteristics along with variability in measurement of noncognitive NPS between studies.

Conclusions

A greater understanding of the most prevalent noncognitive NPS such as depression and anxiety in IIH patients, particularly among females who are obese and facing social and economic marginalization, may help to reduce IIH-associated morbidity. In particular, improved screening and timely management of psychiatric conditions using a multidisciplinary approach may improve IIH outcomes.

背景对特发性颅内高压(IIH)患者神经精神症状(NPS)的描述十分有限。目的我们完成了一项系统性文献综述,以描述特发性颅内高压患者最常见的非认知性 NPS,并研究非认知性 NPS 与特发性颅内高压预后之间的关联。方法在 Ovid Medline、PubMed、PsycInfo、Embase、Web of Science、Cochrane、CINAHL 和 Scopus 数据库中进行了符合《系统综述和元分析首选报告项目》的文献检索。最初的查询产生了 1688 篇独特的文章。这些文章的范围缩小到包括对 IIH 成年患者的非认知性 NPS 进行实证分析的文章。结果最终的 8 篇文章包括 724 名 IIH 患者和 257 名健康对照者。与对照组相比,非认知性 NPS(尤其是焦虑和抑郁)在 IIH 患者中更为常见。IIH患者还报告了更严重的头痛、视觉障碍和整体生活质量下降。结论 更深入地了解 IIH 患者(尤其是肥胖且面临社会和经济边缘化的女性患者)中最普遍的非认知性非认知性非认知性症状(如抑郁和焦虑),可能有助于降低 IIH 相关发病率。特别是,采用多学科方法加强对精神疾病的筛查和及时处理,可能会改善 IIH 的预后。
{"title":"A Systematic Review of Neuropsychiatric Symptoms in Idiopathic Intracranial Hypertension","authors":"Natalia Kosyakova B.S. ,&nbsp;Jacob S. Shaw B.S. ,&nbsp;Anne Reisch M.D. ,&nbsp;Lisa N. Richey B.A ,&nbsp;Sabrina Kentis B.A ,&nbsp;Barry R. Bryant M.D. ,&nbsp;Aaron I. Esagoff B.S. ,&nbsp;Jacob White M.L.S. ,&nbsp;Matthew E. Peters M.D.","doi":"10.1016/j.jaclp.2023.10.005","DOIUrl":"10.1016/j.jaclp.2023.10.005","url":null,"abstract":"<div><h3>Background</h3><p>There is limited characterization of neuropsychiatric symptoms (NPS) in patients with idiopathic intracranial hypertension (IIH). Along with commonly presenting symptoms of IIH, including headache and papilledema, NPS may have a significant impact on IIH outcomes.</p></div><div><h3>Objective</h3><p>We completed a systematic review of the literature to characterize the most common noncognitive NPS in IIH patients and examine associations between noncognitive NPS and IIH outcomes.</p></div><div><h3>Methods</h3><p>A Preferred Reporting Items for Systemic Reviews and Meta-Analysis compliant literature search was conducted in Ovid Medline, PubMed, PsycInfo, Embase, Web of Science, Cochrane, CINAHL, and Scopus databases. The initial query yielded 1688 unique articles. These articles were narrowed to those including empirical analyses of noncognitive NPS in adult patients with IIH.</p></div><div><h3>Results</h3><p>A final cohort of eight articles comprised 724 individuals with IIH and 257 healthy controls. Noncognitive NPS, specifically anxiety and depression, were more common in IIH patients compared to controls. Patients with IIH also reported increased headache, visual disturbances, and overall poorer quality of life. Limitations included heterogeneous sample characteristics along with variability in measurement of noncognitive NPS between studies.</p></div><div><h3>Conclusions</h3><p>A greater understanding of the most prevalent noncognitive NPS such as depression and anxiety in IIH patients, particularly among females who are obese and facing social and economic marginalization, may help to reduce IIH-associated morbidity. In particular, improved screening and timely management of psychiatric conditions using a multidisciplinary approach may improve IIH outcomes.</p></div>","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 39-53"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001350/pdfft?md5=2fec9ec22201a2d26c4fd3dc9b06addc&pid=1-s2.0-S2667296023001350-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeated Cerebellar Symptoms Post-ECT in a Geriatric Patient 一名老年患者ECT治疗后反复出现小脑症状。
IF 2.3 4区 心理学 Q2 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1016/j.jaclp.2023.08.006
Tuna Hasoglu M.D., Brian J. Lee M.D., Ph.D., Irving M. Reti M.B.B.S.
{"title":"Repeated Cerebellar Symptoms Post-ECT in a Geriatric Patient","authors":"Tuna Hasoglu M.D.,&nbsp;Brian J. Lee M.D., Ph.D.,&nbsp;Irving M. Reti M.B.B.S.","doi":"10.1016/j.jaclp.2023.08.006","DOIUrl":"10.1016/j.jaclp.2023.08.006","url":null,"abstract":"","PeriodicalId":52388,"journal":{"name":"Journal of the Academy of Consultation-Liaison Psychiatry","volume":"65 1","pages":"Pages 118-119"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667296023001234/pdfft?md5=9704151ba9bceb3d042e3f16af241ed0&pid=1-s2.0-S2667296023001234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the Academy of Consultation-Liaison Psychiatry
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