Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-113-117
E. Y. Diakonova, A. S. Bekin, A. Gusev, A. Potapov, M. M. Lohmatov, Aleksandra V. Zvonareva, Mariya A. Golberg, S. Yatsyk
Introduction. Crohn’s disease (CD) is an inflammatory disease of the digestive tract of unknown etiology with segmental transmural inflammation of various parts of the gastrointestinal tract. The annual increase in the number of children with newly diagnosed CD, late diagnosis and untimely surgical treatment is one of the urgent problems due to the lack of a single algorithm of surgical treatment. The aim: to determine the effectiveness of surgical treatment of CD in children. Materials and methods. The study included thirty six patients with complicated CD Over the period from 2018 to 2022, a retrospective and prospective analysis of children who received medical care for CD with two-stage surgical treatment (resection of the affected area with enterostomy and subsequent restoration of gastrointestinal continuity) was carried out. Results. Clinical activity according to Pediatric Crohn’s Disease Activity Index (PCDAI) in 23 (63.8%) children before treatment was recorded as high (30.0–75.2 points), in 15 (36.2%) children had average activity (11–29 points). After the staged surgical treatment, there was a change in the indicators — the onset of remission in 2 (5.5%) children and in 34 (94.5%) mild course (p < 0.05). Statistical analysis of anthropometric indicators revealed positive changes (HAZ p < 0.05 and BAZ p < 0.001) with increase in weight and height criteria. Assessment of laboratory dynamics revealed positive changes (p < 0.001) — the absence of anemia, hypoalbuminemia and relief of bacterial inflammation. CD debuted before the age of 10 years in 7 children (19.4%), aged 10 to 16 years — in 29 (80.5%). In 24 (66.7%) children, genetic engineering biological therapy (GEBT) at the time of the development of surgical complications was not performed, from them 15 (62.5%) received hormonal and immunomodulatory therapy while it was not effective, while for 9 (37.5%) patients the timely verification was diagnosed at the stage of development of CD complications. However, the development of surgical complications was noted in 12 (33.3%) children, despite the timely verification and appointment of treatment for genetic engineering biologic therapy (GEBT). Biological therapy was continued for 7 (58.3%) children who received GEBT before surgery, and in 5 (41.7%) patients, treatment was continued with a change of GEBT. The period of stay with a stoma was found to be from 7 to 31 months (Me = 8). Conclusions. In complicated forms of CD in children, despite drug therapy, including GEBT, the development of complications requiring surgical treatment was noted, which indicates an aggressive and progressive course of CD. However, the use of stage-by-stage surgical treatment showed efficiency due to the positive dynamics of anthropometric indicators, laboratory markers, the potency of surgical treatment, and made it possible to achieve stable remission against the background of specific therapy and improve the quality of life in CD children.
介绍。克罗恩病(CD)是一种病因不明的消化道炎症性疾病，伴有胃肠道各部位的节段性跨壁炎症。由于缺乏单一的手术治疗算法，每年新诊断的CD患儿数量不断增加，诊断晚、手术治疗不及时是亟待解决的问题之一。目的:确定手术治疗儿童乳糜泻的有效性。材料和方法。在2018年至2022年期间，该研究纳入了36名患有复杂性乳糜泻的患者，对接受两阶段手术治疗(通过肠造口切除患处并随后恢复胃肠道连续性)的乳糜泻患儿进行了回顾性和前瞻性分析。结果。根据儿科克罗恩病活动性指数(PCDAI)，治疗前23例(63.8%)患儿的临床活动性记录为高(30.0-75.2分)，15例(36.2%)患儿为平均活动性(11-29分)。分阶段手术治疗后，2例(5.5%)患儿出现缓解，34例(94.5%)患儿出现轻度缓解(p < 0.05)。统计分析显示，随着体重和身高标准的增加，人体测量指标呈阳性变化(HAZ p < 0.05, BAZ p < 0.001)。实验室动态评估显示阳性变化(p < 0.001) -没有贫血，低白蛋白血症和减轻细菌性炎症。10岁以下儿童中有7人(19.4%)首次接触CD, 10至16岁儿童中有29人(80.5%)。24例(66.7%)患儿在发生手术并发症时未行基因工程生物治疗(GEBT)，其中15例(62.5%)患儿接受激素和免疫调节治疗无效，9例(37.5%)患儿在发生CD并发症时及时确诊。然而，尽管及时确认并预约了基因工程生物疗法(GEBT)的治疗，但仍有12名(33.3%)儿童出现了手术并发症。术前接受GEBT的7例(58.3%)患儿继续进行生物治疗，5例(41.7%)患儿继续治疗，但改变了GEBT。造口停留时间为7 ~ 31个月(Me = 8)。对于复杂形式的儿童乳糜病，尽管有药物治疗，包括GEBT，并发症的发展需要手术治疗，这表明乳糜病的进程是积极和进展的。然而，由于人体测量指标的积极动态，实验室标记物的使用，分阶段手术治疗显示出效率。使得在特定治疗的背景下实现稳定的缓解和提高CD儿童的生活质量成为可能。
{"title":"The effectiveness of two-stage surgical treatment of children with complicated Crohn’s disease","authors":"E. Y. Diakonova, A. S. Bekin, A. Gusev, A. Potapov, M. M. Lohmatov, Aleksandra V. Zvonareva, Mariya A. Golberg, S. Yatsyk","doi":"10.46563/1560-9561-2023-26-2-113-117","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-113-117","url":null,"abstract":"Introduction. Crohn’s disease (CD) is an inflammatory disease of the digestive tract of unknown etiology with segmental transmural inflammation of various parts of the gastrointestinal tract. The annual increase in the number of children with newly diagnosed CD, late diagnosis and untimely surgical treatment is one of the urgent problems due to the lack of a single algorithm of surgical treatment. \u0000The aim: to determine the effectiveness of surgical treatment of CD in children. \u0000Materials and methods. The study included thirty six patients with complicated CD Over the period from 2018 to 2022, a retrospective and prospective analysis of children who received medical care for CD with two-stage surgical treatment (resection of the affected area with enterostomy and subsequent restoration of gastrointestinal continuity) was carried out. \u0000Results. Clinical activity according to Pediatric Crohn’s Disease Activity Index (PCDAI) in 23 (63.8%) children before treatment was recorded as high (30.0–75.2 points), in 15 (36.2%) children had average activity (11–29 points). After the staged surgical treatment, there was a change in the indicators — the onset of remission in 2 (5.5%) children and in 34 (94.5%) mild course \u0000(p < 0.05). Statistical analysis of anthropometric indicators revealed positive changes (HAZ p < 0.05 and BAZ p < 0.001) with increase in weight and height criteria. Assessment of laboratory dynamics revealed positive changes (p < 0.001) — the absence of anemia, hypoalbuminemia and relief of bacterial inflammation. CD debuted before the age of 10 years in 7 children (19.4%), aged 10 to 16 years — in 29 (80.5%). In 24 (66.7%) children, genetic engineering biological therapy (GEBT) at the time of the development of surgical complications was not performed, from them 15 (62.5%) received hormonal and immunomodulatory therapy while it was not effective, while for 9 (37.5%) patients the timely verification was diagnosed at the stage of development of CD complications. However, the development of surgical complications was noted in 12 (33.3%) children, despite the timely verification and appointment of treatment for genetic engineering biologic therapy (GEBT). Biological therapy was continued for 7 (58.3%) children who received GEBT before surgery, and in 5 (41.7%) patients, treatment was continued with a change of GEBT. The period of stay with a stoma was found to be from 7 to 31 months (Me = 8). \u0000Conclusions. In complicated forms of CD in children, despite drug therapy, including GEBT, the development of complications requiring surgical treatment was noted, which indicates an aggressive and progressive course of CD. However, the use of stage-by-stage surgical treatment showed efficiency due to the positive dynamics of anthropometric indicators, laboratory markers, the potency of surgical treatment, and made it possible to achieve stable remission against the background of specific therapy and improve the quality of life in CD children.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73703617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-95-101
T. I. Kurdyukova, O. Krasnorutskaya, D. Y. Bugrimov, A. N. Shevtsov
Introduction. The microbiota of the upper airways and intestine in preschool children is directly involved in protecting the growing body from acute respiratory infections (ARI), which are the most common infections in children, about 65% of them turn into recurrent respiratory infections (RRI). Aim. To establish changes in the microbiota of the upper airways and intestine in the treatment of ARI in preschool children. Materials and methods. The study involved sixty 1–6 year (Me = 3.38 years) frequently ill children. They were divided into 3 groups depending on the chosen treatment lasting 90 days. Children of group 1 (n = 20) underwent nutrition correction. Children of group 2 (n = 20) received additional probiotics. Children of group 3 (n = 20) received both nutritional correction and probiotics at the prescribed doses. Before and after treatment, the composition of the microbiota of the oropharyngeal zone and intestine was determined by genetic sequencing of the V3–V4 region of the 16S ribosomal RNA gene, followed by bioinformatic analysis. Results. Significant differences were found mainly in the relative content of Firmicutes in the microbiota of patients treated. The content of Firmicutes in the microbiota of children receiving probiotics against the background of nutrition correction (30%) was significantly higher than in patients with nutrition correction (26.91%) and in children receiving only probiotics (25.95%). In patients of different groups, after treatment, a decrease in the content of Proteobacteria in the microbiota of the oropharyngeal zone was revealed. A significant decrease in the relative content of Bacteroidota (by more than 3 times) in 95% of patients, and a decrease in Proteobacteria (by more than 4.5 times) in 100% of patients was also found in the intestinal microbiota of group 3 patients treated with probiotics. In addition, there was a significant increase in the Firmicutes microbiota from 21.97% to 30.07% in 85% of patients, and an increase in the content of Actinobacteriota from 1.9% to 5.7% in 95% of patients. The relative content of undifferentiated microbiota after therapy was also significantly higher (70.08%) than before treatment (58.40%) in 85% of patients.
{"title":"Changes in the microbiota of the upper airways and intestine in the treatment of acute respiratory infections in preschool children","authors":"T. I. Kurdyukova, O. Krasnorutskaya, D. Y. Bugrimov, A. N. Shevtsov","doi":"10.46563/1560-9561-2023-26-2-95-101","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-95-101","url":null,"abstract":"Introduction. The microbiota of the upper airways and intestine in preschool children is directly involved in protecting the growing body from acute respiratory infections (ARI), which are the most common infections in children, about 65% of them turn into recurrent respiratory infections (RRI). Aim. To establish changes in the microbiota of the upper airways and intestine in the treatment of ARI in preschool children. \u0000Materials and methods. The study involved sixty 1–6 year (Me = 3.38 years) frequently ill children. They were divided into 3 groups depending on the chosen treatment lasting 90 days. Children of group 1 (n = 20) underwent nutrition correction. Children of group 2 (n = 20) received additional probiotics. Children of group 3 (n = 20) received both nutritional correction and probiotics at the prescribed doses. Before and after treatment, the composition of the microbiota of the oropharyngeal zone and intestine was determined by genetic sequencing of the V3–V4 region of the 16S ribosomal RNA gene, followed by bioinformatic analysis. \u0000Results. Significant differences were found mainly in the relative content of Firmicutes in the microbiota of patients treated. The content of Firmicutes in the microbiota of children receiving probiotics against the background of nutrition correction (30%) was significantly higher than in patients with nutrition correction (26.91%) and in children receiving only probiotics (25.95%). In patients of different groups, after treatment, a decrease in the content of Proteobacteria in the microbiota of the oropharyngeal zone was revealed. A significant decrease in the relative content of Bacteroidota (by more than 3 times) in 95% of patients, and a decrease in Proteobacteria (by more than 4.5 times) in 100% of patients was also found in the intestinal microbiota of group 3 patients treated with probiotics. In addition, there was a significant increase in the Firmicutes microbiota from 21.97% to 30.07% in 85% of patients, and an increase in the content of Actinobacteriota from 1.9% to 5.7% in 95% of patients. The relative content of undifferentiated microbiota after therapy was also significantly higher (70.08%) than before treatment (58.40%) in 85% of patients.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78319298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-102-106
Dmitry Y. Latyshev, Y. Lobanov, L. Strozenko, Natalia K. Riemer
Introduction. In the adult population, a high prevalence of the gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) can vary from 3 to 79%. As for children, there are a few works on the overlap between functional dyspepsia and IBS, GERD and functional constipation. Aim. To determine the prevalence of overlap of the GERD syndrome with irritable bowel syndrome and functional dyspepsia in school-age children. Materials and methods. The study included ninety eight cases including 71 boy and 27 girls, aged of 7 to 17 years (mean age 11.4 ± 2.1 years) suffered from erosive GERD. The comparison group consisted of 30 patients (11 boys and 19 girls), of mean age of 12.7 ± 1.8 years without erosive GERD). The criterion for inclusion in the main group was the presence of erosive changes in the esophagus according to fibrogastroduodenoscopy, in the comparison group the — manifestation of heartburn, with occurrence, at least twice a week over the past three months and the absence of erosive changes in the esophagus according to fibrogastroduodenoscopy. The exclusion criterion was the presence of organic pathology with sides of the upper (peptic ulcer, etc.) and lower parts of the digestive tract (ulcerative colitis, Crohn’s disease, etc.) Results. Every fourth GERD patient (25.8%) has an overlap with functional bowel diseases, while GERD is more often combined with IBS with diarrhea (15.6%) than IBS with constipation/functional constipation (10.2%). Overlap of IBS with postprandial distress syndrome is much less common — only in 7.0% of children. Conclusion. School-age GERD children are characterized by frequent overlap with functional bowel diseases, the frequency of which reaches 25.8%. The combination of all three diseases (IBS, GERD and postprandial distress syndrome) was observed in 2.3% of cases. These patterns are typical for patients with both erosive and non-erosive forms of GERD.
{"title":"Overlap of some forms of functional pathology of organs of digestion in children","authors":"Dmitry Y. Latyshev, Y. Lobanov, L. Strozenko, Natalia K. Riemer","doi":"10.46563/1560-9561-2023-26-2-102-106","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-102-106","url":null,"abstract":"Introduction. In the adult population, a high prevalence of the gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) can vary from 3 to 79%. As for children, there are a few works on the overlap between functional dyspepsia and IBS, GERD and functional constipation. \u0000Aim. To determine the prevalence of overlap of the GERD syndrome with irritable bowel syndrome and functional dyspepsia in school-age children. \u0000Materials and methods. The study included ninety eight cases including 71 boy and 27 girls, aged of 7 to 17 years (mean age 11.4 ± 2.1 years) suffered from erosive GERD. The comparison group consisted of 30 patients (11 boys and 19 girls), of mean age of 12.7 ± 1.8 years without erosive GERD). The criterion for inclusion in the main group was the presence of erosive changes in the esophagus according to fibrogastroduodenoscopy, in the comparison group the — manifestation of heartburn, with occurrence, at least twice a week over the past three months and the absence of erosive changes in the esophagus according to fibrogastroduodenoscopy. The exclusion criterion was the presence of organic pathology with sides of the upper (peptic ulcer, etc.) and lower parts of the digestive tract (ulcerative colitis, Crohn’s disease, etc.) \u0000Results. Every fourth GERD patient (25.8%) has an overlap with functional bowel diseases, while GERD is more often combined with IBS with diarrhea (15.6%) than IBS with constipation/functional constipation (10.2%). Overlap of IBS with postprandial distress syndrome is much less common — only in 7.0% of children. \u0000Conclusion. School-age GERD children are characterized by frequent overlap with functional bowel diseases, the frequency of which reaches 25.8%. The combination of all three diseases (IBS, GERD and postprandial distress syndrome) was observed in 2.3% of cases. These patterns are typical for patients with both erosive and non-erosive forms of GERD.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85112176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-130-133
D. V. Sutovskaya, A. Burlutskaya, Liubov V. Gorbacheva, Dariya Y. Karachevtseva
Introduction. The state of bone tissue mineralization reflects the quality of the overall development in children and adolescents, their functional status, and the level of general health. The formation of a genetically determined peak bone mass begins at birth and continues until the age of 25 years, providing skeletal strength throughout life. Materials and methods. There were examined five hundred seventy five people including 427 11–18 years schoolchildren and 148 19–25 years students. Bone mineral density (BMD) was assessed by 2-energy X-ray absorptiometry in the distal forearm bones using a DTX-200 densitometer (USA). A decrease in BMD was recorded at Z score < –2.0 SD for a given age and gender. A questionnaire was used to assess risk factors for a decrease in BMD. Results. A decrease in BMD among schoolchildren was registered in 9.9% of respondents. The prevalence of BMD deficiency in girls was 13.3%, in boys — 5.4%. The results of densitometry among students showed a decrease in bone mineralization in 12.1%. A comparative analysis of the decrease in BMD in the age aspect among schoolchildren and students did not reveal significant differences. In all schoolchildren with insufficient BMD, there were noted following risk factors as a pronounced deficiency in dietary calcium intake, physical inactivity, sugar abuse, vitamin D deficiency in 76.1%, deficiency in 23.9%, a history of fractures — 25.5%, smoking — 31.1%. In all students with a decrease in BMD also there were found 4 or more risk factors including low intake of dietary calcium, physical inactivity, low levels of vitamin D (deficiency -64.2%, deficiency — 35.8%), more than 5 cups of coffee per day — 35.1%, smoking — 46.6%, history of fractures — 33%. Conclusion. The goal of educational work among parents, schoolchildren and students should be the formation of correct food preferences, which in the future will be the base for the prevention of a decrease in BMD.
{"title":"Bone mineral density in schoolchildren and students of the city of Krasnodar","authors":"D. V. Sutovskaya, A. Burlutskaya, Liubov V. Gorbacheva, Dariya Y. Karachevtseva","doi":"10.46563/1560-9561-2023-26-2-130-133","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-130-133","url":null,"abstract":"Introduction. The state of bone tissue mineralization reflects the quality of the overall development in children and adolescents, their functional status, and the level of general health. The formation of a genetically determined peak bone mass begins at birth and continues until the age of 25 years, providing skeletal strength throughout life. \u0000Materials and methods. There were examined five hundred seventy five people including 427 11–18 years schoolchildren and 148 19–25 years students. Bone mineral density (BMD) was assessed by 2-energy X-ray absorptiometry in the distal forearm bones using a DTX-200 densitometer (USA). A decrease in BMD was recorded at Z score < –2.0 SD for a given age and gender. A questionnaire was used to assess risk factors for a decrease in BMD. \u0000Results. A decrease in BMD among schoolchildren was registered in 9.9% of respondents. The prevalence of BMD deficiency in girls was 13.3%, in boys — 5.4%. The results of densitometry among students showed a decrease in bone mineralization in 12.1%. A comparative analysis of the decrease in BMD in the age aspect among schoolchildren and students did not reveal significant differences. In all schoolchildren with insufficient BMD, there were noted following risk factors as a pronounced deficiency in dietary calcium intake, physical inactivity, sugar abuse, vitamin D deficiency in 76.1%, deficiency in 23.9%, a history of fractures — 25.5%, smoking — 31.1%. In all students with a decrease in BMD also there were found 4 or more risk factors including low intake of dietary calcium, physical inactivity, low levels of vitamin D (deficiency -64.2%, deficiency — 35.8%), more than 5 cups of coffee per day — 35.1%, smoking — 46.6%, history of fractures — 33%. \u0000Conclusion. The goal of educational work among parents, schoolchildren and students should be the formation of correct food preferences, which in the future will be the base for the prevention of a decrease in BMD.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"1997 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82504147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-107-112
A. B. Alhasov, A. Gurskaya, O. N. Nakovkin, K. A. Kazakova, R. R. Bayazitov, S. Ratnikov, D. M. Akhmedova, Marina A. Konovalenko, M. Varichkina, I. V. Karnuta
The esophageal lung is a rare congenital malformation of the foregut, characterized by the existence of the lung tissue, a segment of the lung, and the main bronchus between the esophagus and the part of respiratory system. Because of the rare occurrence of this defect, examples of the treatment of this disease can be found only in foreign literature, in Russian-language sources, there are no described cases of treatment of the esophageal lung. In this regard, the literature data was analyzed and there was presented, clinical picture, classification, diagnosis, and treatment of this defect, as well as a case from practical activities was carried out: diagnosis and treatment of a premature one month baby with an esophageal lung.
{"title":"Diagnosis and treatment of esophageal lung in a premature baby","authors":"A. B. Alhasov, A. Gurskaya, O. N. Nakovkin, K. A. Kazakova, R. R. Bayazitov, S. Ratnikov, D. M. Akhmedova, Marina A. Konovalenko, M. Varichkina, I. V. Karnuta","doi":"10.46563/1560-9561-2023-26-2-107-112","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-107-112","url":null,"abstract":"The esophageal lung is a rare congenital malformation of the foregut, characterized by the existence of the lung tissue, a segment of the lung, and the main bronchus between the esophagus and the part of respiratory system. Because of the rare occurrence of this defect, examples of the treatment of this disease can be found only in foreign literature, in Russian-language sources, there are no described cases of treatment of the esophageal lung. In this regard, the literature data was analyzed and there was presented, clinical picture, classification, diagnosis, and treatment of this defect, as well as a case from practical activities was carried out: diagnosis and treatment of a premature one month baby with an esophageal lung.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88990184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-145-148
Gulzhan I. Sarsenbayeva, A. Sadykova, Almas B. Berdibekov, Olesya Z. Khasanova
The article describes a clinical report of a combination of congenital heart disease due to total anomalous pulmonary venous drainage into the right atrium with congenital lung disease — lymphoangiectasia in a newborn infant. The role of extracardiac pathology on the course and outcome of cardiac surgery and the complexity of early diagnosis of a rare lung pathology are presented
{"title":"A rare case of the combination of total abnormal pulmonary vein drainage with congenital lung lymphangiectasia","authors":"Gulzhan I. Sarsenbayeva, A. Sadykova, Almas B. Berdibekov, Olesya Z. Khasanova","doi":"10.46563/1560-9561-2023-26-2-145-148","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-145-148","url":null,"abstract":"The article describes a clinical report of a combination of congenital heart disease due to total anomalous pulmonary venous drainage into the right atrium with congenital lung disease — lymphoangiectasia in a newborn infant. The role of extracardiac pathology on the course and outcome of cardiac surgery and the complexity of early diagnosis of a rare lung pathology are presented","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85109394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-89-94
O. A. Sedashkina, G. Poretskova, G. Makovetskaya
Introduction. A comprehensive analysis of the polymorphisms of the genes of the renin-angiotensin system in children with different nosological forms of nephropathies is a necessary step in determining the clinical and genetic features of the formation of chronic kidney disease (CKD). Aim: to establish the features of ACE (D/I), GT (Thr174Met), AGT (Met235Thr) and AGTR1 (A1166C) gene polymorphisms in CKD children and determine their significance in the progression of the disease. Materials and methods. A retrospective and prospective study included one hundered 1 to 17 years children with nephropathies, examined in the children’s nephrology department of the Samara Regional Hospital over 10 years. In children, the identification of single nucleotide polymorphisms of genes was carried out using an allele-specific polymerase chain amplification reaction using test systems. Evaluation of clinical and paraclinical markers of progression in CKD was carried out twice a year. The results of the study were evaluated with the calculation of the Student–Fisher criteria and correlation analysis. Results. in patients with kidney diseases, there was a trend towards an increase in the occurrence of single nucleotide polymorphisms of genes that affect the renin-angiotensin system (RAS). CKD patients at the stage 3–5 accounted for 35%. They had D/D ACE alleles combined with alleles AGT Thr174Met (27.9 ± 6.83%) and Met235Thr (41.86 ± 7.5%), Thr235Thr (30.2 ± 7.0%) and AGTR1 A1166C (37.2 ± 7.32%) more often than in milder CKD (0 and 7.5 ± 3.37%; 5.2 ± 2.94% and 5.2 ± 2.94%; respectively, p ≤ 0.010). Соnclusion. The study of clinical and genetic features of CKD is relevant for the purpose of timely implementation of preventive measures.
{"title":"Polymorphisms of genes of the renin-angiotensin system: significance in the progression of chronic kidney disease in children","authors":"O. A. Sedashkina, G. Poretskova, G. Makovetskaya","doi":"10.46563/1560-9561-2023-26-2-89-94","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-89-94","url":null,"abstract":"Introduction. A comprehensive analysis of the polymorphisms of the genes of the renin-angiotensin system in children with different nosological forms of nephropathies is a necessary step in determining the clinical and genetic features of the formation of chronic kidney disease (CKD). \u0000Aim: to establish the features of ACE (D/I), GT (Thr174Met), AGT (Met235Thr) and AGTR1 (A1166C) gene polymorphisms in CKD children and determine their significance in the progression of the disease. \u0000Materials and methods. A retrospective and prospective study included one hundered 1 to 17 years children with nephropathies, examined in the children’s nephrology department of the Samara Regional Hospital over 10 years. In children, the identification of single nucleotide polymorphisms of genes was carried out using an allele-specific polymerase chain amplification reaction using test systems. Evaluation of clinical and paraclinical markers of progression in CKD was carried out twice a year. The results of the study were evaluated with the calculation of the Student–Fisher criteria and correlation analysis. \u0000Results. in patients with kidney diseases, there was a trend towards an increase in the occurrence of single nucleotide polymorphisms of genes that affect the renin-angiotensin system (RAS). CKD patients at the stage 3–5 accounted for 35%. They had D/D ACE alleles combined with alleles AGT Thr174Met (27.9 ± 6.83%) and Met235Thr (41.86 ± 7.5%), Thr235Thr (30.2 ± 7.0%) and AGTR1 A1166C (37.2 ± 7.32%) more often than in milder CKD (0 and 7.5 ± 3.37%; 5.2 ± 2.94% and 5.2 ± 2.94%; respectively, p ≤ 0.010). \u0000Соnclusion. The study of clinical and genetic features of CKD is relevant for the purpose of timely implementation of preventive measures.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75203145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-134-139
M. Basargina, I. Davydova, Kh.R. Turko, V. Bondar, A. Fisenko, A. A. Seliverstova
Early detection of such a formidable complication of bronchopulmonary dysplasia (BPD) as pulmonary hypertension (PH) is an urgent problem in pediatrics. Echocardiography is currently recognized as the most accessible and non-invasive method for determining pressure in the pulmonary artery. Disorders of alveogenesis and angiogenesis of the vessels of the small circulatory circle in premature infants forming BPD require careful echocardiographic control with using additional analysis of changes in the systolic eccentricity index (EI) as a reliable marker of PH in BPD infants. To increase the information content, it is also necessary to expand the use of EchoCG data in combination with analysis of the blood content of B type natriuretic peptide or the N-terminal pro-B-type natriuretic peptide.
{"title":"The importance of echocardiography in the instrumental diagnosis of pulmonary hypertension in children with bronchopulmonary dysplasia","authors":"M. Basargina, I. Davydova, Kh.R. Turko, V. Bondar, A. Fisenko, A. A. Seliverstova","doi":"10.46563/1560-9561-2023-26-2-134-139","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-134-139","url":null,"abstract":"Early detection of such a formidable complication of bronchopulmonary dysplasia (BPD) as pulmonary hypertension (PH) is an urgent problem in pediatrics. Echocardiography is currently recognized as the most accessible and non-invasive method for determining pressure in the pulmonary artery. Disorders of alveogenesis and angiogenesis of the vessels of the small circulatory circle in premature infants forming BPD require careful echocardiographic control with using additional analysis of changes in the systolic eccentricity index (EI) as a reliable marker of PH in BPD infants. To increase the information content, it is also necessary to expand the use of EchoCG data in combination with analysis of the blood content of B type natriuretic peptide or the N-terminal pro-B-type natriuretic peptide.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78812186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.46563/1560-9561-2023-26-2-140-144
L. Adamyan, E. Sibirskaya, S. Sharkov, Y. Kirillova, L. Pivazyan, M.A. Loshkareva, Z. U. Dzharullaeva
Introduction. Inflammatory diseases of the pelvic organs (IDPO) are common forms of pathology, which are often accompanied by serious complications. Aim: to determine the leading reproductive outcomes in adolescent girls with IDPO. Materials and methods. The review is based on the analysis of the features of the course of IDPO and the impact of their complications on the reproductive function of adolescent girls. A search was conducted in the PubMed and Cochrane Library databases with a depth of 5 years. Results. It has been established that the highest incidence of IDPO in adolescent girls is at the age of 15–19 years due to the early onset of sexual activity, the lack of effective contraception and the presence of several frequently infected partners. Recurrent infections, chronic pelvic pain, purulent complications (salpingitis, pyosalpinx, tubo-ovarian abscess), ectopic pregnancy, premature birth, endometriosis and infertility are the leading outcomes of IDPO in adolescent girls. It was revealed that the absence of sexual activity does not exclude the occurrence of IDPO and its complications in girls. This is due to the state of immune protection against infectious pathogens in girls, and the qualitative and quantitative composition of the microbiota of the genital tract. Therefore, it is so necessary to manage and conduct a wide screening of adolescents for the presence of sexually transmitted infections to prevent their negative impact on the fertility of young males and females, and effective training of adolescents on all significant issues of reproductive health.
{"title":"Reproductive outcomes in adolescent girls with inflammatory diseases of the pelvic organs","authors":"L. Adamyan, E. Sibirskaya, S. Sharkov, Y. Kirillova, L. Pivazyan, M.A. Loshkareva, Z. U. Dzharullaeva","doi":"10.46563/1560-9561-2023-26-2-140-144","DOIUrl":"https://doi.org/10.46563/1560-9561-2023-26-2-140-144","url":null,"abstract":"Introduction. Inflammatory diseases of the pelvic organs (IDPO) are common forms of pathology, which are often accompanied by serious complications. \u0000Aim: to determine the leading reproductive outcomes in adolescent girls with IDPO. \u0000Materials and methods. The review is based on the analysis of the features of the course of IDPO and the impact of their complications on the reproductive function of adolescent girls. A search was conducted in the PubMed and Cochrane Library databases with a depth of 5 years. \u0000Results. It has been established that the highest incidence of IDPO in adolescent girls is at the age of 15–19 years due to the early onset of sexual activity, the lack of effective contraception and the presence of several frequently infected partners. Recurrent infections, chronic pelvic pain, purulent complications (salpingitis, pyosalpinx, tubo-ovarian abscess), ectopic pregnancy, premature birth, endometriosis and infertility are the leading outcomes of IDPO in adolescent girls. It was revealed that the absence of sexual activity does not exclude the occurrence of IDPO and its complications in girls. This is due to the state of immune protection against infectious pathogens in girls, and the qualitative and quantitative composition of the microbiota of the genital tract. Therefore, it is so necessary to manage and conduct a wide screening of adolescents for the presence of sexually transmitted infections to prevent their negative impact on the fertility of young males and females, and effective training of adolescents on all significant issues of reproductive health.","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"365 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78009729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts of VIII Annual All-Russian Conference For Students And Young Scientists “Pediatric Readings”","authors":"A. Editorial","doi":"10.15690/rpj.v4i2.2508","DOIUrl":"https://doi.org/10.15690/rpj.v4i2.2508","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":52396,"journal":{"name":"Russian Journal of Pediatric Hematology and Oncology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85105268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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