Pub Date : 2023-01-01DOI: 10.1504/ijwoe.2023.10056760
Sanawi M. Sharahiley, Dr Vinay Kandpal
{"title":"The Impact of Monetary and Non-Monetary Reward Systems upon Creativity: How Rational Are Saudi Professional Employees","authors":"Sanawi M. Sharahiley, Dr Vinay Kandpal","doi":"10.1504/ijwoe.2023.10056760","DOIUrl":"https://doi.org/10.1504/ijwoe.2023.10056760","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1504/ijwoe.2023.10060214
Marlena Plavsic, Katarina Kosteli, Marli Gonan Boac
{"title":"The role of colleagues in HR managers' emotions elicited by strategic decision making","authors":"Marlena Plavsic, Katarina Kosteli, Marli Gonan Boac","doi":"10.1504/ijwoe.2023.10060214","DOIUrl":"https://doi.org/10.1504/ijwoe.2023.10060214","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134891134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16eCollection Date: 2022-01-01DOI: 10.1155/2022/8589121
Qingyi Lu, Haixu Jiang, Qingqing Zhu, Jie Xu, Yanan Cai, Guiyang Huo, Kai Yuan, Guangrui Huang, Anlong Xu
Rheumatoid arthritis (RA) is a common autoimmune disease worldwide. Neutrophils play critical roles in the onset and development of RA and are the promising target for RA treatment. Tetrandrine is a bis-benzyl isoquinoline alkaloid derived from the traditional Chinese herbal Stephania tetrandra S. Moore. Tetrandrine is effective in alleviating RA by inhibiting macrophage inflammatory response, fibroblast overproliferation, and pannus formation. However, whether tetrandrine regulates the activities of neutrophils in RA is largely unknown. In this study, we adopted adjuvant-induced arthritis (AA) murine model to explore the effect of tetrandrine on RA and neutrophils. Twenty-eight mice were divided into four groups. The control group was injected with PBS in the limbs and treated with PBS by intraperitoneal injection (i.p.) from Day 10 to Day 37. The arthritis murine model was induced by injecting FCA into the ankle joints of hind limbs. The AA group, the AA + TET group, and the AA + DEX group mice were treated with PBS, tetrandrine (6 mg/kg), or dexamethasone (1 mg/kg) i.p. daily, respectively. Arthritic scores were evaluated, and the joint diameter was measured every three days. A cytometric bead assay was performed to measure the concentrations of IFN-γ, TNF-α, and IL-6 in the serum. H&E staining and Safranin O-fast staining were adopted to monitor the tissue changes in the joint. Immunohistochemistry assays were applied to detect the MPO, NE, CitH3, and PAD4 expression levels. To assess the effect of tetrandrine on neutrophil activities in vitro, CCK8 tests were applied to determine cell viability. The qPCR and ELISA were performed to determine IL-1β and IL-6 expression levels. Immunofluorescence assays were performed to measure the formation of NETs. The results indicated that tetrandrine significantly alleviated the symptoms of RA in terms of the ankle diameter (from 4.629 ± 2.729 to 3.957 ± 0.257; P < 0.01) and ankle score (from 4.000 ± 0.000 to 3.286 ± 0.756; P < 0.05). Tetrandrine treatment significantly increased the cartilage areas and decreased serum IL-6 significantly (from 5.954 ± 2.127 to 2.882 ± 2.013; P < 0.01). The immunohistochemistry assays also showed decreased expression levels of NE, MPO, PAD4, and CitH3 induced by tetrandrine in comparison with the AA group (P < 0.01). The qPCR assays and ELISAs showed that tetrandrine had an anti-inflammatory effect in vitro by significantly inhibiting IL-6 (P < 0.01). The immunofluorescence assays showed that NET formation induced by PMA could be reduced by tetrandrine (P < 0.01). In conclusion, tetrandrine has good efficacy in treating RA by regulating neutrophil-involved inflammation and NET formation.
类风湿性关节炎（RA）是一种全球常见的自身免疫性疾病。中性粒细胞在类风湿关节炎的发病和发展过程中起着关键作用，是治疗类风湿关节炎的理想靶点。Tetrandrine是一种双苄基异喹啉生物碱，提取自传统中药Stephania tetrandra S. Moore。四氢化可的松通过抑制巨噬细胞炎症反应、成纤维细胞过度增殖和泛酸形成，有效缓解 RA 病情。然而，四氢萘啶是否能调节 RA 中嗜中性粒细胞的活动尚不清楚。本研究采用佐剂诱导的关节炎（AA）小鼠模型，探讨四氢化萘对RA和中性粒细胞的影响。28只小鼠分为四组。对照组小鼠四肢注射 PBS，第 10 天至第 37 天腹腔注射 PBS 治疗。向小鼠后肢踝关节注射 FCA 诱导关节炎模型。AA组、AA + TET组和AA + DEX组小鼠每天分别肌注PBS、四氢嘧啶（6 mg/kg）或地塞米松（1 mg/kg）。每三天评估关节炎评分并测量关节直径。用细胞计数珠检测血清中IFN-γ、TNF-α和IL-6的浓度。采用 H&E 染色和 Safranin O 快速染色法监测关节组织的变化。免疫组化检测MPO、NE、CitH3和PAD4的表达水平。为了评估四氢萘啶对体外中性粒细胞活性的影响，采用了 CCK8 试验来确定细胞活力。通过 qPCR 和 ELISA 检测 IL-1β 和 IL-6 的表达水平。免疫荧光试验用于检测 NET 的形成。结果表明，四氢化可的松能明显缓解RA症状，包括踝关节直径（从4.629±2.729降至3.957±0.257；P＜0.01）和踝关节评分（从4.000±0.000降至3.286±0.756；P＜0.05）。四氢化可的松治疗可明显增加软骨面积，并显著降低血清IL-6（从5.954 ± 2.127降至2.882 ± 2.013；P < 0.01）。免疫组化检测也显示，与 AA 组相比，四氢化可的松诱导的 NE、MPO、PAD4 和 CitH3 表达水平降低（P < 0.01）。qPCR 检测和酶联免疫吸附试验表明，四氢化甘油具有体外抗炎作用，能显著抑制 IL-6（P < 0.01）。免疫荧光试验表明，四氢化萘啶可减少 PMA 诱导的 NET 形成（P < 0.01）。总之，四氢化甘油通过调节中性粒细胞参与的炎症和NET的形成，对治疗RA具有良好的疗效。
{"title":"Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities.","authors":"Qingyi Lu, Haixu Jiang, Qingqing Zhu, Jie Xu, Yanan Cai, Guiyang Huo, Kai Yuan, Guangrui Huang, Anlong Xu","doi":"10.1155/2022/8589121","DOIUrl":"10.1155/2022/8589121","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a common autoimmune disease worldwide. Neutrophils play critical roles in the onset and development of RA and are the promising target for RA treatment. Tetrandrine is a bis-benzyl isoquinoline alkaloid derived from the traditional Chinese herbal <i>Stephania tetrandra</i> S. Moore. Tetrandrine is effective in alleviating RA by inhibiting macrophage inflammatory response, fibroblast overproliferation, and pannus formation. However, whether tetrandrine regulates the activities of neutrophils in RA is largely unknown. In this study, we adopted adjuvant-induced arthritis (AA) murine model to explore the effect of tetrandrine on RA and neutrophils. Twenty-eight mice were divided into four groups. The control group was injected with PBS in the limbs and treated with PBS by intraperitoneal injection (i.p.) from Day 10 to Day 37. The arthritis murine model was induced by injecting FCA into the ankle joints of hind limbs. The AA group, the AA + TET group, and the AA + DEX group mice were treated with PBS, tetrandrine (6 mg/kg), or dexamethasone (1 mg/kg) i.p. daily, respectively. Arthritic scores were evaluated, and the joint diameter was measured every three days. A cytometric bead assay was performed to measure the concentrations of IFN-<i>γ</i>, TNF-<i>α,</i> and IL-6 in the serum. H&E staining and Safranin O-fast staining were adopted to monitor the tissue changes in the joint. Immunohistochemistry assays were applied to detect the MPO, NE, CitH3, and PAD4 expression levels. To assess the effect of tetrandrine on neutrophil activities <i>in vitro</i>, CCK8 tests were applied to determine cell viability. The qPCR and ELISA were performed to determine IL-1<i>β</i> and IL-6 expression levels. Immunofluorescence assays were performed to measure the formation of NETs. The results indicated that tetrandrine significantly alleviated the symptoms of RA in terms of the ankle diameter (from 4.629 ± 2.729 to 3.957 ± 0.257; <i>P</i> < 0.01) and ankle score (from 4.000 ± 0.000 to 3.286 ± 0.756; <i>P</i> < 0.05). Tetrandrine treatment significantly increased the cartilage areas and decreased serum IL-6 significantly (from 5.954 ± 2.127 to 2.882 ± 2.013; <i>P</i> < 0.01). The immunohistochemistry assays also showed decreased expression levels of NE, MPO, PAD4, and CitH3 induced by tetrandrine in comparison with the AA group (<i>P</i> < 0.01). The qPCR assays and ELISAs showed that tetrandrine had an anti-inflammatory effect <i>in vitro</i> by significantly inhibiting IL-6 (<i>P</i> < 0.01). The immunofluorescence assays showed that NET formation induced by PMA could be reduced by tetrandrine (<i>P</i> < 0.01). In conclusion, tetrandrine has good efficacy in treating RA by regulating neutrophil-involved inflammation and NET formation.</p>","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"4 1","pages":"8589121"},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88799864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10051641
M. Abdullah, Aisha Azhar, Bushra Mumtaz, Afshan Azam Khan
{"title":"Examining the relationship of Paternalistic Leadership, Extent of Centralization and Employees Voice Behaviour","authors":"M. Abdullah, Aisha Azhar, Bushra Mumtaz, Afshan Azam Khan","doi":"10.1504/ijwoe.2022.10051641","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10051641","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10047140
Oluwatobi A. Ogunmokun, J. Ikhide
{"title":"Emotional regulation strategies, Eustress, and Personal initiative-taking: Evidence from frontline Journalists.","authors":"Oluwatobi A. Ogunmokun, J. Ikhide","doi":"10.1504/ijwoe.2022.10047140","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10047140","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10050721
A. Srivastava, Selvan Thamizh, Mohit Yadav, N. Vihari
{"title":"Impact of Workplace Acculturation on Expatriate Job Performance: Does Inter-Cultural consciousness and Self Efficacy play a role","authors":"A. Srivastava, Selvan Thamizh, Mohit Yadav, N. Vihari","doi":"10.1504/ijwoe.2022.10050721","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10050721","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10043234
N. Garg
{"title":"Gratitude and Work-Family Enrichment among Indian Female Workforce: Exploring the Mediating Role of Psychological Capital","authors":"N. Garg","doi":"10.1504/ijwoe.2022.10043234","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10043234","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10043236
Ritu Gupta, S. Hans
{"title":"INFLUENCE OF SPOUSAL SUPPORT AND COWORKER SUPPORT ON SATISFACTION WITH WORK-FAMILY BALANCE","authors":"Ritu Gupta, S. Hans","doi":"10.1504/ijwoe.2022.10043236","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10043236","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2022.10044300
Marli Jooste, Nicoleen Coetzee
{"title":"The Role of Emotional Intelligence in the Experience of Burnout among South African Leaders Working in Financial Roles","authors":"Marli Jooste, Nicoleen Coetzee","doi":"10.1504/ijwoe.2022.10044300","DOIUrl":"https://doi.org/10.1504/ijwoe.2022.10044300","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijwoe.2023.10050617
R. Abraham, Anuradha Iddagoda, Ravi Chinta
{"title":"DO THE DIMENSIONS OF WORKPLACE SPIRITUALITY INFLUENCE ORGANIsATIONAL OUTCOMES A PATH ANALYTIC MODEL AND MODERATED REGRESSION MODEL","authors":"R. Abraham, Anuradha Iddagoda, Ravi Chinta","doi":"10.1504/ijwoe.2023.10050617","DOIUrl":"https://doi.org/10.1504/ijwoe.2023.10050617","url":null,"abstract":"","PeriodicalId":52483,"journal":{"name":"International Journal of Work Organisation and Emotion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66709692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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