Pub Date : 2023-07-12DOI: 10.21608/eajbsc.2023.307035
Alaa Haroun, M. Bashandy, A. Hussein
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{"title":"A Novel Study on the Hematological and Physiological Disturbance of Ivermectin-COVID 19 Treatment Abuse in Male Wistar Rats","authors":"Alaa Haroun, M. Bashandy, A. Hussein","doi":"10.21608/eajbsc.2023.307035","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.307035","url":null,"abstract":"----------------------","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78621869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-29DOI: 10.21608/eajbsc.2023.305315
Maha M. Shouman, K. Alsolami, Heba Hossam
Purpose : Malignant ascites is a common manifestation of advanced cancer. It conveys a poor prognosis affecting the quality of life. Treatment options include chemotherapy and simple drainage techniques for symptomatic relief. The aspect of malignant ascites in promoting metastasis and therapy resistance is crucial. However, chemotherapy resistance is manifested by the innate and/or acquired ability of cancer cells to resist the effects of chemotherapeutics. Methods : Malignant ascites were induced by intraperitoneal inoculation of EAC in mice followed by flow cytometric analysis that was used to evaluate the cell cycle phases and increased proliferation of ascites cells as well as the interpretation of the proliferation index and apoptosis percentage. In addition, the expression of p53 and p21 as cell cycle regulators were increased. Apoptosis was assessed by analysis of the pro-apoptotic Bax and the anti-apoptotic Bcl-2 expression. Results : Both acefylline and amygdalin combination with cisplatin showed a reduction in Ki-67 expression and arrested the cell cycle. Moreover, amygdalin treatment showed a significant reduction in S-phase and the proliferation index. This combination also restored the apoptotic cell’s apoptotic ability proved by the apoptosis index as well as the increased p53, p21 and Bcl-2 expression while reducing Bax expression in ascites fluid. Based on our results amygdaline showed a distinct effect associated with a significant reduction in the malignant ascites burden with markedly decreased proliferation and induced apoptosis. Conclusion : These findings provide a basis for the theory that combined chemoprevention is an effective treatment strategy that can be used along with conventional chemotherapy.
{"title":"Flow Cytometric Analysis Outlines the Impact of Trending Anticancer Agents on Cell Regulators In Mouse Malignant Ascites","authors":"Maha M. Shouman, K. Alsolami, Heba Hossam","doi":"10.21608/eajbsc.2023.305315","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.305315","url":null,"abstract":"Purpose : Malignant ascites is a common manifestation of advanced cancer. It conveys a poor prognosis affecting the quality of life. Treatment options include chemotherapy and simple drainage techniques for symptomatic relief. The aspect of malignant ascites in promoting metastasis and therapy resistance is crucial. However, chemotherapy resistance is manifested by the innate and/or acquired ability of cancer cells to resist the effects of chemotherapeutics. Methods : Malignant ascites were induced by intraperitoneal inoculation of EAC in mice followed by flow cytometric analysis that was used to evaluate the cell cycle phases and increased proliferation of ascites cells as well as the interpretation of the proliferation index and apoptosis percentage. In addition, the expression of p53 and p21 as cell cycle regulators were increased. Apoptosis was assessed by analysis of the pro-apoptotic Bax and the anti-apoptotic Bcl-2 expression. Results : Both acefylline and amygdalin combination with cisplatin showed a reduction in Ki-67 expression and arrested the cell cycle. Moreover, amygdalin treatment showed a significant reduction in S-phase and the proliferation index. This combination also restored the apoptotic cell’s apoptotic ability proved by the apoptosis index as well as the increased p53, p21 and Bcl-2 expression while reducing Bax expression in ascites fluid. Based on our results amygdaline showed a distinct effect associated with a significant reduction in the malignant ascites burden with markedly decreased proliferation and induced apoptosis. Conclusion : These findings provide a basis for the theory that combined chemoprevention is an effective treatment strategy that can be used along with conventional chemotherapy.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75837732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-29DOI: 10.21608/eajbsc.2023.306499
B. Twaij, H. Al-Hakeim
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{"title":"Insulin Resistance in End-Stage Renal Disease Patients: A Review","authors":"B. Twaij, H. Al-Hakeim","doi":"10.21608/eajbsc.2023.306499","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.306499","url":null,"abstract":"on","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84262320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21608/eajbsc.2023.305089
N. Mahmood, Rafah Al-Sammarai, Rawaa Al-Fanar
{"title":"Evaluation of the Role of Nesfatin-1 and Myonectin as A Diagnostic Marker for Polycystic Ovary Syndrome and Also for Treatment Response with Metformin","authors":"N. Mahmood, Rafah Al-Sammarai, Rawaa Al-Fanar","doi":"10.21608/eajbsc.2023.305089","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.305089","url":null,"abstract":"","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"128 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74378132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21608/eajbsc.2023.304915
H. Chfat, E. Zimam
nucleus was functionalized with sodium azide to produce 4-azido-N-(5-methylisoxazol-3-yl)benzenesulfonamide. The end 1,2,3-triazoles were synthesized via a click reaction of the azide compound and triple bond derivatives that attached with alkyl chain or phenyl group in good yields. The structures of all prepared compounds were identified by using NMR and IR techniques. The synthesized compounds were screened for their in vitro antibacterial activity against one gram-positive bacteria S. aureus and one gram-negative bacteria E. coli. Among the synthesized compounds, compound 12 was found to be the most potent against staphylococcus aureus with MIC = 20 μg/mL compared with the other prepared compounds. Whereas compound 15 was found to be the most potent against Escherichia coli with MIC = 21 μg/mL compared with the other end compounds.
核被叠氮化钠功能化，得到4-叠氮- n -(5-甲基异恶唑-3-基)苯磺酰胺。通过叠氮化合物与烷基链或苯基连接的三键衍生物的连锁反应合成了末端1,2,3-三唑，收率较高。利用核磁共振和红外光谱技术对所制备化合物的结构进行了鉴定。对合成的化合物进行体外抑菌活性筛选，测定其对1种革兰氏阳性菌金黄色葡萄球菌和1种革兰氏阴性菌大肠杆菌的抑菌活性。在所合成的化合物中，化合物12对金黄色葡萄球菌的抑制作用最强，MIC = 20 μg/mL。而化合物15对大肠杆菌的抑制作用最强，其MIC值为21 μg/mL。
{"title":"Synthesis, Characterization, and Study of Antibacterial Activity of Some New Amphiphilic Sulfamethoxazole Derivatives","authors":"H. Chfat, E. Zimam","doi":"10.21608/eajbsc.2023.304915","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.304915","url":null,"abstract":"nucleus was functionalized with sodium azide to produce 4-azido-N-(5-methylisoxazol-3-yl)benzenesulfonamide. The end 1,2,3-triazoles were synthesized via a click reaction of the azide compound and triple bond derivatives that attached with alkyl chain or phenyl group in good yields. The structures of all prepared compounds were identified by using NMR and IR techniques. The synthesized compounds were screened for their in vitro antibacterial activity against one gram-positive bacteria S. aureus and one gram-negative bacteria E. coli. Among the synthesized compounds, compound 12 was found to be the most potent against staphylococcus aureus with MIC = 20 μg/mL compared with the other prepared compounds. Whereas compound 15 was found to be the most potent against Escherichia coli with MIC = 21 μg/mL compared with the other end compounds.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78974385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-24DOI: 10.21608/eajbsc.2023.304197
Duha Mahmood, M. Kareem, Israa N. Witwit
) hours. The prepared ligand and their complex characterized by FT-IR, Mass, Elemental analyses, and conductivity then antimicrobial activity of the complex was studied against two pathogenic strains of E.coli and S. aurous at three values of concentrations of (10 ppm,20 ppm and 30 ppm by using standards by disk-diffusion method.
{"title":"Synthesis, Characterization of Novel Triazin Complex, and Studying its Antimicrobial Activity","authors":"Duha Mahmood, M. Kareem, Israa N. Witwit","doi":"10.21608/eajbsc.2023.304197","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.304197","url":null,"abstract":") hours. The prepared ligand and their complex characterized by FT-IR, Mass, Elemental analyses, and conductivity then antimicrobial activity of the complex was studied against two pathogenic strains of E.coli and S. aurous at three values of concentrations of (10 ppm,20 ppm and 30 ppm by using standards by disk-diffusion method.","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80977881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-23DOI: 10.21608/eajbsc.2023.304196
M. Hameed, Manal F. Al-Khakani
Osteoporosis, characterized by low bone mineral density (BMD) and increased fracture risk
骨质疏松症，以低骨密度(BMD)和骨折风险增加为特征
{"title":"Adiponectin and Leptin Levels as Potential Biomarkers for Osteoporosis in Patients with Type 2 Diabetes Mellitus","authors":"M. Hameed, Manal F. Al-Khakani","doi":"10.21608/eajbsc.2023.304196","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.304196","url":null,"abstract":"Osteoporosis, characterized by low bone mineral density (BMD) and increased fracture risk","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73115874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-19DOI: 10.21608/eajbsc.2023.307820
Mohammed Abdul Shahed, A. Mageed
The study focuses on the synthesis of isatin-barbituric acid compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either barbituric acid, along with formaldehyde. This reaction results in the formation of Isatin-barbituric acid derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. Spectroscopic methods including FTIR, 1 H NMR
{"title":"Synthesis and Biological Activity of Barbituric acid- linked Isatin Derivatives","authors":"Mohammed Abdul Shahed, A. Mageed","doi":"10.21608/eajbsc.2023.307820","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.307820","url":null,"abstract":"The study focuses on the synthesis of isatin-barbituric acid compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either barbituric acid, along with formaldehyde. This reaction results in the formation of Isatin-barbituric acid derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. Spectroscopic methods including FTIR, 1 H NMR","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86601539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.21608/eajbsc.2023.303858
Zain Alhindi, Afnan M. Shakoori
Capripoxviruses are a group of extremely contagious viruses that cause substantial economic losses in livestock, especially goats and sheep. The purpose of this investigation was to determine the genetic diversity, antigenicity
{"title":"P32 Gene PCR Evaluation for Capripox’s Diagnostic Potential and Immunogenic Effect","authors":"Zain Alhindi, Afnan M. Shakoori","doi":"10.21608/eajbsc.2023.303858","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.303858","url":null,"abstract":"Capripoxviruses are a group of extremely contagious viruses that cause substantial economic losses in livestock, especially goats and sheep. The purpose of this investigation was to determine the genetic diversity, antigenicity","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"25 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79742454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-11DOI: 10.21608/eajbsc.2023.303806
K. Alsolami, M. Alharthi, Shahad Al-harthi, Refal Al-nemari, Jood Al-nemar, R. Al-Ghamdi, Al-Hanouf A. Al-Malki
----------------------Keywords
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{"title":"Socio-Demographic and Environmental Factors Impacting Asthma Exacerbations in Children in Taif City, Saudi Arabia","authors":"K. Alsolami, M. Alharthi, Shahad Al-harthi, Refal Al-nemari, Jood Al-nemar, R. Al-Ghamdi, Al-Hanouf A. Al-Malki","doi":"10.21608/eajbsc.2023.303806","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.303806","url":null,"abstract":"----------------------Keywords","PeriodicalId":52600,"journal":{"name":"Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72735587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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