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Gallbladder Neuroendocrine Carcinoma: A Case Report with Radiological–Pathological Correlation 胆囊神经内分泌癌1例影像学病理分析
Pub Date : 2022-02-24 DOI: 10.1055/s-0042-1742676
Karamvir Chandel, A. Lal, R. Srinivas, D. Chatterjee, Vikas Gupta
Abstract Neuroendocrine tumors (NET) of the biliary system, specifically the gallbladder (GB), are extremely rare, accounting for only 0.2% of all NETs. The majority of GBNETs are discovered by chance during a histological examination of GB samples at autopsy, after cholecystectomy, or after surgery for other suspected biliary pathology. GBNETs are thought to develop from preexisting endocrine cells in the GB's neck or from induced endocrine cells caused by intestinal metaplasia of the body and fundus. We present a case of squamous cell carcinoma of the GB with neuroendocrine differentiation due to its rarity.
胆道系统神经内分泌肿瘤(NET),特别是胆囊(GB)极为罕见,仅占全部NET的0.2%。大多数GBNETs是在尸检、胆囊切除术后或其他疑似胆道病理手术后对GB样本进行组织学检查时偶然发现的。GBNETs被认为是由先前存在于GB颈部的内分泌细胞或由身体和眼底肠化生引起的诱导内分泌细胞发展而来。我们报告一例罕见的GB鳞状细胞癌伴神经内分泌分化。
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引用次数: 1
Evaluation of Hypervascular Focal Liver Lesions Utilizing Virtual Monoenergetic Images from Third-Generation Dual-Source Dual-Energy Computed Tomography 利用第三代双源双能计算机断层扫描的虚拟单能图像评估肝脏高血管局灶性病变
Pub Date : 2022-02-18 DOI: 10.1055/s-0042-1742677
Niyas Narappulan, V. Arunachalam, Ezhilmathi Alavandar, Swathigha Selvaraja, Rupa Renganathan, M. Cherian
Objectives The purpose of our study was to evaluate the virtual monochromatic imaging in detecting hypervascular focal liver lesions in the late arterial phase with third-generation dual-source dual-energy computed tomography and to assess its image quality. Materials and Methods In our study, 80 patients were included. Contrast-enhanced images in the late arterial phase (in the dual-energy mode) were acquired and were post-processed in Syngo, via workstation, using Monoenergetic + software. Five sets of images, one polychromatic energy image (corresponding to 120 kVp single-energy image) and four virtual monoenergetic image (VMI) sets at 40, 50, 60, and 70 keV levels, were generated. All these images were analyzed both objectively and subjectively. The attenuation values were measured, and the contrast-to-noise ratio (CNR) of liver and tumor were measured and compared objectively in each dataset. Image noise, image contrast, and diagnostic confidence for liver lesion detection were analyzed subjectively using a five-point scale system. Statistical analysis was performed using Kolmogorov–Smirnov, analysis of variance, and Kruskal–Wallis tests. Results Among the VMI, maximum image noise was observed in the 40 keV image, with a gradual reduction in the image noise being noted with an increase in the VMI energy. The CNR of the hepatic parenchyma and the tumor gradually increased with a reduction in VMI energy from 70 to 40 keV. On subjective analysis, image contrast and image noise were observed to be more in low VMI datasets. In lesion detection, diagnostic confidence with an excellent confidence level was observed with a decrease in VMI energy. Conclusion VMI datasets of 40 to 70 keV from third-generation dual-source DECT provide superior diagnostic accuracy for detecting hypervascular liver lesions. Considering the image noise and lesion detection rate among the VMI datasets, 60 keV VMI is the most helpful dataset for increased liver lesion detection with good image quality.
目的评价虚拟单色成像在第三代双源双能计算机断层扫描检测晚期动脉期肝局灶性高血管病变中的应用价值,并评价其图像质量。材料与方法本研究共纳入80例患者。获取动脉晚期(双能量模式)的增强图像,并通过工作站在Syngo中使用Monoenergetic +软件进行后处理。生成了5组图像,1幅多色能量图像(对应120 kVp的单能量图像)和4组虚拟单能量图像(VMI),分别为40、50、60和70 keV水平。对这些图像进行了客观和主观的分析。测量衰减值,并在每个数据集中测量肝脏和肿瘤的噪比(CNR),并进行客观比较。使用五分制主观分析图像噪声、图像对比度和肝脏病变检测的诊断置信度。采用Kolmogorov-Smirnov、方差分析和Kruskal-Wallis检验进行统计分析。结果在VMI中,40 keV时图像噪声最大,随着VMI能量的增加,图像噪声逐渐降低。随着VMI能量从70 keV降至40 keV,肝实质和肿瘤的CNR逐渐增加。在主观分析中,观察到低VMI数据集的图像对比度和图像噪声更多。在病变检测中,随着VMI能量的降低,诊断置信度具有极好的置信度。结论第三代双源DECT 40 ~ 70 keV的VMI数据集对肝脏高血管性病变具有较高的诊断准确性。考虑到VMI数据集的图像噪声和病变检出率,60 keV的VMI数据集具有较好的图像质量,是提高肝脏病变检出率最有帮助的数据集。
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引用次数: 1
Typical and Atypical Imaging Findings of Hepatocellular Carcinoma on Multiphasic MDCT Scan in Histologically Proved Cases 经组织学证实的肝细胞癌多期多层螺旋ct的典型与不典型影像学表现
Pub Date : 2022-02-18 DOI: 10.1055/s-0042-1742771
U. Prasad, Deepak Kumar, Rashmi Rani Bharti, S. Suman, Aishwerya Singh, R. Kumar
Abstract Objective  The purpose of this study was to find out the incidence of typical and atypical radiological imaging findings of hepatocellular carcinoma (HCC) on multiphase multidetector computed tomography (MDCT) scans in histologically proven cases. Materials and Methods  A multiphase computed tomography study of 73 patients with histologically proven HCC was evaluated by a radiologist. Our multiphasic protocol was composed of precontrast, arterial, portal, and delayed venous phases. The reviewers analyzed the CT images for tumor size, enhancement patterns of HCC in different phases, relative timing of washout, internal cystic changes, and presence of dysmorphic intratumoral vessel aneurysms or arteriovenous shunt. Results  Most of the cases (95.9%) showed typical enhancement patterns in MDCT, i.e., enhancements in the arterial phase with the portal or delayed venous phase contrast washout. Three cases (4.9%) out of 73 HCC showed enhancements in the portal phase and washout in the delayed venous phase. Seven cases out of total 73 HCC (9.5%) patients showed heterogeneous enhancements in both arterial and portal phases and contrast washout in the delayed venous phase. Venous thrombosis was noted in about 44 cases (60%) out of total 73 patients, in which portal vein thrombosis was more common than hepatic veins/inferior vena cava. Conclusion  Most of the HCC show typical enhancement patterns, i.e., heterogeneous enhancements in the arterial phase and washout in the portal venous phase when we use MDCT. These findings are higher than those described previously. However, in our study, the main difference with MDCT was lower frequency of intratumoral pseudoaneurysm and bile duct invasion, and intratumoral fat and calcification (atypical character of HCC) were not found which were rare findings in previous study.
【摘要】目的探讨经组织学证实的肝细胞癌(HCC)多期多探测器计算机断层扫描(MDCT)典型和非典型影像学表现的发生率。材料和方法一位放射科医生对73例组织学证实的HCC患者进行了多期计算机断层扫描研究。我们的多相方案包括造影前、动脉期、门静脉期和延迟静脉期。研究人员分析了CT图像的肿瘤大小、不同阶段HCC的增强模式、洗脱的相对时间、内部囊性改变以及是否存在畸形的瘤内血管动脉瘤或动静脉分流。结果绝大多数病例(95.9%)在MDCT上表现为典型的增强模式,即动脉期增强伴门脉期或延迟静脉期对比消失。73例HCC中有3例(4.9%)表现为门静脉期增强和延迟静脉期消失。73例HCC患者中有7例(9.5%)在动脉期和门脉期均表现为异质性增强,在延迟静脉期表现为造影剂洗脱。73例患者中约有44例(60%)出现静脉血栓形成,其中门静脉血栓发生率高于肝静脉/下腔静脉。结论大多数HCC在MDCT上表现为典型的增强模式,即动脉期不均匀增强,门静脉期消失。这些发现比之前描述的要高。然而,在我们的研究中,与MDCT的主要区别在于肿瘤内假性动脉瘤和胆管侵犯的频率较低,并且未发现肿瘤内脂肪和钙化(HCC的不典型特征),这是以往研究中罕见的发现。
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引用次数: 0
Principles and Available Hardware in DECT DECT的原理和可用硬件
Pub Date : 2022-02-18 DOI: 10.1055/s-0042-1742772
Ezhilmathi Alavandar, V. Arunachalam, Niyas Narappulan, G. S. Mahadevan, Ravindar Kashyap, P. Mehta, M. Cherian
Computed tomography (CT) has undergone a phenomenal evolution since its introduction in 1971 and has revolutionized diagnostic radiology. It is now the cornerstone of diagnostic imaging and has become an inevitable part of the management of patients. Among all the advancements and breakthroughs witnessed over the years, the most recent and most advanced is the dual-energy CT (DECT), also known as spectral CT, introduced in 2006. In DECT, two datasets are obtained by scanning with two different energy spectra (low and high energy). The difference in attenuation can differentiate materials with different elemental compositions but similar attenuation in single-energy CT. Therefore, it has widespread clinical applications based on its potential for material decomposition and virtual monoenergetic imaging. In this review, the principle and hardware of DECT will be presented with an overview of its clinical applications.
计算机断层扫描(CT)自1971年问世以来经历了惊人的发展,并彻底改变了诊断放射学。它现在是诊断成像的基石,并已成为患者管理中不可避免的一部分。在这些年来所见证的所有进步和突破中,最新和最先进的是2006年推出的双能CT (DECT),也称为频谱CT。在DECT中,用两种不同的能谱(低能谱和高能谱)扫描得到两个数据集。在单能CT中,衰减的差异可以区分元素组成不同但衰减相似的材料。因此,基于其材料分解和虚拟单能成像的潜力,它具有广泛的临床应用。本文将介绍DECT的原理和硬件,并对其临床应用进行综述。
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引用次数: 5
Role of Dual-Energy Computed Tomography in Gallbladder Disease: A Review 双能计算机断层扫描在胆囊疾病中的作用综述
Pub Date : 2022-02-18 DOI: 10.1055/s-0042-1743173
T. Singh, P. Gupta
Gallbladder diseases are common and include a spectrum ranging from benign to cancer. Imaging plays an integral role in the diagnosis and in guiding appropriate management. While most patients with gallstone (GS) diseases can be evaluated with ultrasound, those with complicated GS disease, suspicion of cancer, or staging of cancer need additional cross-sectional imaging. Computed tomography (CT) is widely available and is often the imaging test of choice following an equivocal ultrasound or negative ultrasound in patients with unexplained symptoms. Conventional CT has limited sensitivity in detecting GS or common bile duct stones. In other scenarios, including diagnosis of acute cholecystitis (AC) and characterization of gallbladder wall thickening, an increase in accuracy using novel techniques is desirable. Dual-energy computed tomography (DECT) is increasingly incorporated into clinical practice. DECT has shown promising results in the detection of cholesterol stones that otherwise go unnoticed on conventional CT. However, its role beyond GS disease has largely been unexplored. In this review, we discuss the available literature on the DECT in biliary diseases and discuss the potential applications of this technique.
胆囊疾病很常见,包括从良性到癌症的一系列疾病。影像在诊断和指导适当的治疗中起着不可或缺的作用。虽然大多数胆结石(GS)疾病患者可以通过超声进行评估,但那些患有复杂的GS疾病,怀疑癌症或癌症分期的患者需要额外的横断面成像。计算机断层扫描(CT)是广泛可用的,通常是选择的影像学检查后,模棱两可的超声或阴性超声患者的不明原因的症状。常规CT在检测GS或胆总管结石时灵敏度有限。在其他情况下,包括诊断急性胆囊炎(AC)和表征胆囊壁增厚,使用新技术提高准确性是可取的。双能计算机断层扫描(DECT)越来越多地纳入临床实践。在检测胆固醇结石方面,DECT显示出了很好的结果,否则在常规CT上就会被忽视。然而,它在GS疾病之外的作用在很大程度上尚未被探索。在这篇综述中,我们讨论了DECT在胆道疾病中的现有文献,并讨论了该技术的潜在应用。
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引用次数: 4
Large Solid Pseudopapillary Tumor Pancreas with Extensive Splenoportal Thrombosis and Malignant Transformation—A Rare Entity 胰腺大实性假乳头状肿瘤伴广泛脾门血栓形成及恶性转化-罕见病例
Pub Date : 2022-02-17 DOI: 10.1055/s-0042-1742679
T. Pratap, D. Jacob, A. Yadav, M. Jalal, I. Mathew
Abstract Solid pseudopapillary tumor (SPT) is an uncommon low-grade malignant cystic exocrine neoplasm of the pancreas that typically affects young women. The tumor has an excellent prognosis after surgical resection. Vascular involvement is usually not seen at presentation. Local recurrence and metastasis are also rare. Herein, we present a case of large, locally advanced SPT in a young female with splenoportal extension and malignant transformation.
实性假乳头状瘤(SPT)是一种罕见的胰腺低级别恶性囊性外分泌肿瘤,通常发生在年轻女性。手术切除后肿瘤预后良好。通常在就诊时未见血管受累。局部复发和转移也很少见。在此,我们提出一个病例大,局部进展SPT在一个年轻的女性脾门延伸和恶性转化。
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引用次数: 0
Pictorial Depiction of an Institutional Experience of Acute Abdominal Emergencies in Cancer Patients with COVID-19 Infection 新型冠状病毒感染的癌症患者急腹症的机构经验的图片描述
Pub Date : 2022-02-09 DOI: 10.1055/s-0042-1742678
A. Jajodia, A. Jena, S. Pasricha, S. Goel, G. Gupta, S. Puri
Abstract The ongoing pandemic of coronavirus disease 2019 (COVID-19) poses a diagnostic and management challenge to the clinician, which further gets heightened when patients present with abdominal complications in a cancer care center. The atypical manifestations of the disease provide a diagnostic conundrum to the radiologist and leave the pathologist in the perils of guiding further management to the clinician. Although previous literature shows gastrointestinal involvement in COVID-19, we present a case series of complicated subjects with clinical imaging as a pictorial essay and relevant pathology. The abdominal manifestations of COVID-19 are complicated in cancer patients where a variety of other differentials such as infiltration by metastatic disease and drug-related chemo toxicity effects must be taken into account, which may be ruled out by clinical workup, adequate imaging, and laboratory tests. This would help achieve better clinical acumen and modify management in these subjects.
持续的冠状病毒病2019 (COVID-19)大流行给临床医生带来了诊断和管理方面的挑战,当癌症护理中心的患者出现腹部并发症时,这一挑战进一步加剧。该疾病的非典型表现为放射科医生提供了一个诊断难题,并使病理学家在指导临床医生进一步管理的危险中。尽管之前的文献显示COVID-19涉及胃肠道,但我们提出了一系列复杂的病例,包括临床影像学和相关病理学。在癌症患者中,COVID-19的腹部表现是复杂的,必须考虑转移性疾病的浸润和药物相关的化学毒性作用等多种其他鉴别,这些可能通过临床检查、充分的影像学检查和实验室检查来排除。这将有助于提高这些学科的临床敏锐度和改进管理。
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引用次数: 0
Dual-Energy Computed Tomography in Diffuse Liver Diseases 弥漫性肝病的双能计算机断层扫描
Pub Date : 2022-02-08 DOI: 10.1055/s-0042-1742432
U. Marri, K. Madhusudhan
Dual-energy computed tomography (DECT) is an advancement in the field of CT, where images are acquired at two energies. Materials are identified and quantified based on their attenuation pattern at two different energy beams using various material decomposition algorithms. With its ability to identify and quantify materials such as fat, calcium, iron, and iodine, DECT adds great value to conventional CT and has innumerable applications in body imaging. Continuous technological advances in CT scanner hardware, material decomposition algorithms, and image reconstruction software have led to considerable growth of these applications. Among all organs, the liver is the most widely investigated by DECT, and DECT has shown promising results in most liver applications. In this article, we aim to provide an overview of the role of DECT in the assessment of diffuse liver diseases, mainly the deposition of fat, fibrosis, and iron and review the most relevant literature.
双能量计算机断层扫描(DECT)是CT领域的一项进步,它以两种能量获取图像。根据材料在两种不同能量束下的衰减模式,使用各种材料分解算法对材料进行识别和量化。由于能够识别和量化脂肪、钙、铁和碘等物质,DECT为传统CT增加了巨大的价值,在身体成像中有着无数的应用。CT扫描仪硬件、材料分解算法和图像重建软件的不断技术进步导致了这些应用的显著增长。在所有器官中,肝脏是DECT研究最广泛的器官,DECT在大多数肝脏应用中显示出良好的效果。在本文中,我们旨在概述DECT在弥漫性肝脏疾病评估中的作用,主要是脂肪沉积,纤维化和铁,并回顾最相关的文献。
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引用次数: 2
Clinical and Radiological Features of Cronkhite–Canada Syndrome: A Case Report cronkite - canada综合征的临床和放射学特征1例报告
Pub Date : 2022-02-01 DOI: 10.1055/s-0042-1742433
L. Lokesh, V. Jindal, P. Das, R. Yadav, G. Makharia, K. Madhusudhan
Abstract Cronkhite–Canada syndrome is a rare non-hereditary disease characterized by gastrointestinal hamartomatous polyposis and protein-losing enteropathy. The presenting symptoms are onychodystrophy, skin pigmentation, alopecia, weight loss, and diarrhea. Diagnosis is suggested by a combination of clinical, imaging, and endoscopy findings, and histology is necessary for confirmation. Here we describe a case of a 54-year-old man presenting with watery diarrhea, colicky abdominal pain, nasal obstruction, and weight loss for 6 months. Endoscopy showed multiple polyps in the stomach, duodenum, and colon. These were seen on computed tomography (CT) enterography along with polyps in the small bowel. A final diagnosis was made after the biopsy.
cronkite - canada综合征是一种罕见的非遗传性疾病,以胃肠道错构瘤性息肉病和蛋白质丢失性肠病为特征。主要症状为甲营养不良、皮肤色素沉着、脱发、体重减轻和腹泻。诊断建议结合临床,影像学和内窥镜检查结果,组织学是必要的确认。在这里我们描述一个54岁的男性病例,表现为水样腹泻、绞痛腹痛、鼻塞和体重下降6个月。内窥镜检查显示胃、十二指肠和结肠有多发息肉。这些都是在计算机断层扫描(CT)肠造影中发现的,并伴有小肠息肉。活检后做出最终诊断。
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引用次数: 0
Impact of Replacing Old C-Arms on Reducing Radiation Exposure 更换旧c型臂对减少辐射暴露的影响
Pub Date : 2022-01-28 DOI: 10.1055/s-0041-1740476
G. Robbins, Nicholas J. Wellnitz, P. Darwin
Abstract Fluoroscopy is increasingly used by gastroenterologists for endoscopic procedures such as endoscopic retrograde cholangiopancreatography. Unfortunately, fluoroscopy exposes patients and staff to ionizing radiation, which can cause DNA damage, cell death, genetic defects, and cancer. These adverse effects are more likely to occur with increased exposure time and higher radiation doses; therefore, all efforts to decrease exposure are helpful. In this study, we investigate the impact that updating the C-Arms in our endoscopy unit will have on radiation exposure by comparing ionizing radiation effects of the OEC 9900 Elite to the newer OEC Elite. After replicating the setup of a typical endoscopic retrograde cholangiopancreatography, ionizing radiation and energy were measured at the bedside and the head of the bed with each machine. At both positions, the newer OEC Elite C-Arm emitted less energy and ionizing radiation than the OEC 9900 Elite. Continuous imaging with OEC 9900 Elite emitted 0.12 mSv/h at the head of the bed and 0.49 mSv/h at the bedside, while the OEC Elite only emitted 0.04 mSv/h and 0.14 mSv/h, respectively. These values are measures of radiation-induced cancer risk, otherwise known as stochastic risk. The differences grow more significant when extrapolated to show radiation differences for an average procedure (approximately 8 minutes of fluoroscopy time) and the procedural volume for an entire year. In an effort to use as little radiation as possible, we see that we can significantly reduce radiation exposure to our staff by upgrading from an OEC 9900 Elite to and OEC Elite.
透视越来越多地被胃肠病学家用于内镜手术,如内镜逆行胆管造影术。不幸的是,透视检查使患者和工作人员暴露在电离辐射下,这会导致DNA损伤、细胞死亡、遗传缺陷和癌症。随着暴露时间的延长和辐射剂量的增加,这些不良影响更有可能发生;因此,所有减少接触的努力都是有益的。在本研究中,我们通过比较OEC 9900 Elite和更新后的OEC Elite的电离辐射效应,研究更新内窥镜单元c臂对辐射暴露的影响。在复制了典型的内窥镜逆行胆管造影术的设置后,在每台机器的床边和床头测量电离辐射和能量。在这两个位置,较新的OEC Elite C-Arm比OEC 9900 Elite发射更少的能量和电离辐射。OEC 9900 Elite连续成像在床头和床边的辐射分别为0.12 mSv/h和0.49 mSv/h,而OEC Elite的辐射分别仅为0.04 mSv/h和0.14 mSv/h。这些数值是辐射致癌风险的量度,也被称为随机风险。当外推显示平均手术(约8分钟透视时间)的辐射差异和一整年的手术量时,差异变得更加显著。为了尽可能少地使用辐射,我们发现通过将OEC 9900 Elite升级到OEC Elite,我们可以显着减少员工的辐射暴露。
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引用次数: 0
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Journal of Gastrointestinal and Abdominal Radiology
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