Nur Nabila Sabrina, Heriyadi Manan, Hadrians Kesuma Putra
Introduction. Breast cancer is a non-communicable disease that has become a health problem in the world. One of the risk factors for breast cancer is hormonal factors that can be obtained from the use of hormonal contraception. This study describes the relationship between the incidence of breast cancer and the use of hormonal contraception at RSUP Dr. Mohammad Hoesin Palembang in 2021. Method. This is an observational analytic study with a case-control design. The data used are secondary data and primary data. The sample are women with breast cancer and benign breast tumors at RSUP Dr. Mohammad Hoesin Palembang in 2021who met the inclusion criteria. Results. There was a significant relationship between the use of hormonal contraceptives (p = 0.003), duration of the use of hormonal contraceptives>5 years (p = 0.004), the type of injectable hormonal contraceptive (p = 0.001), the type of hormonal pills (p = 0.018) and a family history (p = 0.001). Meanwhile, there was no significant relationship between the type of hormonal contraceptive implant (p = 0.724), parity (p = 1.000), and age at menarche (p = 0.129),with the incidence of breast cancer. Conclusion. There is a significant relationship between the use of hormonal contraception, duration of use of hormonal contraception >5 years, type of injectable hormonal contraceptive use, type of use of hormonal contraceptive pills, and family history of breast cancer with breast cancer incidence.
{"title":"The Relations Between Breast Cancer and Hormonal Contraception Acceptor At RSUP Dr. Mohammad Hoesin Palembang in 2021","authors":"Nur Nabila Sabrina, Heriyadi Manan, Hadrians Kesuma Putra","doi":"10.32539/bji.v9i2.157","DOIUrl":"https://doi.org/10.32539/bji.v9i2.157","url":null,"abstract":"Introduction. Breast cancer is a non-communicable disease that has become a health problem in the world. One of the risk factors for breast cancer is hormonal factors that can be obtained from the use of hormonal contraception. This study describes the relationship between the incidence of breast cancer and the use of hormonal contraception at RSUP Dr. Mohammad Hoesin Palembang in 2021. Method. This is an observational analytic study with a case-control design. The data used are secondary data and primary data. The sample are women with breast cancer and benign breast tumors at RSUP Dr. Mohammad Hoesin Palembang in 2021who met the inclusion criteria. Results. There was a significant relationship between the use of hormonal contraceptives (p = 0.003), duration of the use of hormonal contraceptives>5 years (p = 0.004), the type of injectable hormonal contraceptive (p = 0.001), the type of hormonal pills (p = 0.018) and a family history (p = 0.001). Meanwhile, there was no significant relationship between the type of hormonal contraceptive implant (p = 0.724), parity (p = 1.000), and age at menarche (p = 0.129),with the incidence of breast cancer. Conclusion. There is a significant relationship between the use of hormonal contraception, duration of use of hormonal contraception >5 years, type of injectable hormonal contraceptive use, type of use of hormonal contraceptive pills, and family history of breast cancer with breast cancer incidence.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"2 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135974075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Proton pump inhibitors (PPIs) are the main therapy for stomach acid disorders to date. The disadvantage of PPI is the difficulty of controlling symptoms at night, such as tightness, chest pain, and coughing cough. Potassium competitive acid blockers (P-CAB) are a new class in the management of stomach acid disorders. Potassium competitive acid blockers work by a different mechanism, which binds non-covalently to H+/K+-ATPase. This mechanism results in a faster, stronger, and long-lasting suppression effect of gastric acid production. Besides being able to cure gastric complaints at night, P-CAB increases the success of Helicobacter pylori eradication. The safety of the use of this P_CAB drug, according to research is quite mild and acceptable. Currently, examples of P-CAB groups on the market are vonoprazan and tegoprazan. This narrative review is intended to provide further insight into this potassium competitive acid blocker (P-CAB) class of drugs.
{"title":"Potassium Competitive Acid Blockers: A New Paradigm For The Management of Stomach Acid Disorders","authors":"Gerie Amarendra, Wawan Kurniawan, Mizanul Adli","doi":"10.32539/bji.v9i2.164","DOIUrl":"https://doi.org/10.32539/bji.v9i2.164","url":null,"abstract":"
 Proton pump inhibitors (PPIs) are the main therapy for stomach acid disorders to date. The disadvantage of PPI is the difficulty of controlling symptoms at night, such as tightness, chest pain, and coughing cough. Potassium competitive acid blockers (P-CAB) are a new class in the management of stomach acid disorders. Potassium competitive acid blockers work by a different mechanism, which binds non-covalently to H+/K+-ATPase. This mechanism results in a faster, stronger, and long-lasting suppression effect of gastric acid production. Besides being able to cure gastric complaints at night, P-CAB increases the success of Helicobacter pylori eradication. The safety of the use of this P_CAB drug, according to research is quite mild and acceptable. Currently, examples of P-CAB groups on the market are vonoprazan and tegoprazan. This narrative review is intended to provide further insight into this potassium competitive acid blocker (P-CAB) class of drugs.
","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135974164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ermalinda Kurnia, Fiona Widyasari, Puspa Zuleika, Ahmad Hifni, M Ricky Al Hafiz Sazili
Introduction. The deviated nasal septum is found in 80% of people in the world either with or without specific symptoms. Mladina has divided the classification of deviation of the septum nasi into seven parts based on the findings of the deviation to facilitate the determination of diagnosis, therapy, and which type often appears. This study aims to determine the characteristics of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021. Methods. Data was obtained from medical records of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021. Results. The majority of patients were in the age range of 16-25 years (37.8%) and male gender (64.9%). The most common etiology was congenital (86.5%). Clinical manifestation mainly is nasal obstruction (94.6%), and the most common secondary diagnoses found are concha hypertrophy (54%) and allergic rhinitis (16.2%). The most common pathological condition was narrowed cavum nasal (91.9%). The majority of patients had type III deviation (51.4%). All patients were treated with septoplasty (100%). Conclusion. Most patients are predominantly male aged between 16-25 years. Congenital factors primarily caused this condition, leading to complaints of nasal obstruction. Secondary diagnoses included concha hypertrophy and allergic rhinitis. Physical examinations often revealed a narrowed nasal cavity. Most patients exhibited type III septal deviation and all patients were treated with septoplasty
介绍。世界上80%的人有或没有特定症状的鼻中隔偏曲。Mladina根据偏曲的表现将鼻中隔偏曲的分类分为七个部分，以便于确定诊断、治疗以及经常出现的类型。本研究旨在确定2021年1月至12月在Palembang的Dr. Mohammad Hoesin总医院的鼻中隔偏曲患者的特征。方法。数据来自2021年1月至12月在巨港穆罕默德·侯赛因综合医院(Dr. Mohammad Hoesin General Hospital)的鼻中隔偏曲患者的医疗记录。结果。患者以16 ~ 25岁为主(37.8%)，男性占64.9%。最常见的病因是先天性(86.5%)。临床表现以鼻塞为主(94.6%)，继发诊断以鼻甲肥大(54%)和变应性鼻炎(16.2%)最为常见。最常见的病理状态为鼻腔狭窄(91.9%)。大多数患者为III型偏差(51.4%)。所有患者均行鼻中隔成形术(100%)。结论。大多数患者以16-25岁的男性为主。先天性因素主要引起这种情况，导致鼻塞的投诉。继发诊断为鼻甲肥大、变应性鼻炎。体检常发现鼻腔狭窄。大多数患者表现为III型鼻中隔偏曲，所有患者均行鼻中隔成形术
{"title":"The Characteristics of Deviated Nasal Septum Patients and Computed Tomography Findings at Dr. Mohammad Hoesin General Hospital Palembang","authors":"Ermalinda Kurnia, Fiona Widyasari, Puspa Zuleika, Ahmad Hifni, M Ricky Al Hafiz Sazili","doi":"10.32539/bji.v9i1.142","DOIUrl":"https://doi.org/10.32539/bji.v9i1.142","url":null,"abstract":"Introduction. The deviated nasal septum is found in 80% of people in the world either with or without specific symptoms. Mladina has divided the classification of deviation of the septum nasi into seven parts based on the findings of the deviation to facilitate the determination of diagnosis, therapy, and which type often appears. This study aims to determine the characteristics of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021. Methods. Data was obtained from medical records of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021. Results. The majority of patients were in the age range of 16-25 years (37.8%) and male gender (64.9%). The most common etiology was congenital (86.5%). Clinical manifestation mainly is nasal obstruction (94.6%), and the most common secondary diagnoses found are concha hypertrophy (54%) and allergic rhinitis (16.2%). The most common pathological condition was narrowed cavum nasal (91.9%). The majority of patients had type III deviation (51.4%). All patients were treated with septoplasty (100%). Conclusion. Most patients are predominantly male aged between 16-25 years. Congenital factors primarily caused this condition, leading to complaints of nasal obstruction. Secondary diagnoses included concha hypertrophy and allergic rhinitis. Physical examinations often revealed a narrowed nasal cavity. Most patients exhibited type III septal deviation and all patients were treated with septoplasty","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Apri Yanti, Irfannuddin Irfannuddin, Nilam Kusuma Anggraeni
Introduction. Voice disorder or dysphonia is a condition that includes all changes in a person’s voice including tone, intensity, phonation, and others caused by laryngeal disorders. Each sound production disorder can be evaluated through the VHI-30 questionnaire. Therefore, data are needed regarding the relationship of the extent of the lesion location site to the degree of VHI-30 produced in dysphonic patients with benign vocal cord lesions. Methods. Observational research using cross sectional design. Data collection using medical record data on 30 dysphonic patients with benign vocal cord lesions who underwent surgery in the ENT department in RSMH in January 2019 to June 2022. Results. Out of the 30 patients with benign vocal cord lesions, age of 31-45 and 46-60 age groups were most found 11(36,7%) Female gender was found 16(53,3%) and the non-professional voice user category was found the highest 28 (93,3%). The 1–6-month onset group was the highest 12(40,0%). The most common location of benign vocal cord lesions was in 1/3 anterior 8(26,7%), and the most common type of benign lesion was vocal cord nodules 13(43,3%). Severe degree VHI-30 were most found 18(60,0%). The area of bilateral locations along the vocal cords had a significant relationship, with p-value of 0,040 (p<0,05), to the degree of VHI-30 when compared to the unilateral location of the anterior 2/3 of the vocal cords. Conclusion. The benign lesions’ position of bilateral along the vocal cord has a significant relationship to the severe degree of VHI-30
{"title":"Relationship Between The Location Of Benign Vocal Cord Lesion And The Degree Of Voice Handicap Index-30","authors":"Lisa Apri Yanti, Irfannuddin Irfannuddin, Nilam Kusuma Anggraeni","doi":"10.32539/bji.v9i1.134","DOIUrl":"https://doi.org/10.32539/bji.v9i1.134","url":null,"abstract":"Introduction. Voice disorder or dysphonia is a condition that includes all changes in a person’s voice including tone, intensity, phonation, and others caused by laryngeal disorders. Each sound production disorder can be evaluated through the VHI-30 questionnaire. Therefore, data are needed regarding the relationship of the extent of the lesion location site to the degree of VHI-30 produced in dysphonic patients with benign vocal cord lesions. Methods. Observational research using cross sectional design. Data collection using medical record data on 30 dysphonic patients with benign vocal cord lesions who underwent surgery in the ENT department in RSMH in January 2019 to June 2022. Results. Out of the 30 patients with benign vocal cord lesions, age of 31-45 and 46-60 age groups were most found 11(36,7%) Female gender was found 16(53,3%) and the non-professional voice user category was found the highest 28 (93,3%). The 1–6-month onset group was the highest 12(40,0%). The most common location of benign vocal cord lesions was in 1/3 anterior 8(26,7%), and the most common type of benign lesion was vocal cord nodules 13(43,3%). Severe degree VHI-30 were most found 18(60,0%). The area of bilateral locations along the vocal cords had a significant relationship, with p-value of 0,040 (p<0,05), to the degree of VHI-30 when compared to the unilateral location of the anterior 2/3 of the vocal cords. Conclusion. The benign lesions’ position of bilateral along the vocal cord has a significant relationship to the severe degree of VHI-30","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Functional capacity defines as an individual's ability to do activities of daily living and is assessed by VO2 max as a basic indicator of physical fitness. The more sufficient hemoglobin levels, the more oxygen can be transported, so the body will be more optimal to produce energy. This study aimed to determine the relationship between hemoglobin levels and the functional capacity of the body in young adults. Methods This was an analytic observational study with a cross-sectional approach. A total 34 healthy young adults who met the inclusion and exclusion criteria were recruited as subjects in this study. Functional capacity was assessed by six minutes walking test, and hemoglobin level was measured using the strip test method. Data analysis was performed using the Spearman correlation test in SPSS version 25 with a significance level of p <0.05. Results. The average value of hemoglobin levels in respondents was 16.0 mg/dl. The mean functional capacity based on the predicted VO2 max is 20.3 kg/m2 and 530m based on the distance. Spearman's test results showed that there was a significant correlation between hemoglobin levels and predicted VO2 max (p=0.001). Conclusion. Our study concluded a significant correlation between hemoglobin level and functional capacity assessed by predicted VO2 max. Therefore, hemoglobin level should be considered as a factor in enhancing functional capacity.
{"title":"Correlation Between Hemoglobin Level And Functional Capacity In Young Adult Population","authors":"Fiona Rista Utami, Patwa Amani","doi":"10.32539/bji.v9i1.160","DOIUrl":"https://doi.org/10.32539/bji.v9i1.160","url":null,"abstract":"Introduction. Functional capacity defines as an individual's ability to do activities of daily living and is assessed by VO2 max as a basic indicator of physical fitness. The more sufficient hemoglobin levels, the more oxygen can be transported, so the body will be more optimal to produce energy. This study aimed to determine the relationship between hemoglobin levels and the functional capacity of the body in young adults. Methods This was an analytic observational study with a cross-sectional approach. A total 34 healthy young adults who met the inclusion and exclusion criteria were recruited as subjects in this study. Functional capacity was assessed by six minutes walking test, and hemoglobin level was measured using the strip test method. Data analysis was performed using the Spearman correlation test in SPSS version 25 with a significance level of p <0.05. Results. The average value of hemoglobin levels in respondents was 16.0 mg/dl. The mean functional capacity based on the predicted VO2 max is 20.3 kg/m2 and 530m based on the distance. Spearman's test results showed that there was a significant correlation between hemoglobin levels and predicted VO2 max (p=0.001). Conclusion. Our study concluded a significant correlation between hemoglobin level and functional capacity assessed by predicted VO2 max. Therefore, hemoglobin level should be considered as a factor in enhancing functional capacity.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy which has cytotoxic effects. One of the plants that have the same effect is the berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae, which grows wild and is often referred to as a poisonous plant. However, some people traditionally use this plant as a medicinal plant such as for antifungal, anthelmintic, analgesic, and anti-inflammatory. This plant contains naphthoquinones as one of the cytotoxic chemical compounds and another metabolite secondary such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. Methods. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larva that has been prepared and the value of mortality was observed. Results. The result of the cytotoxic activity test of ethanolic extract of berenuk fruit on A. salina larva had the LC50 value of 529.386 ppm which is categorized as toxic. Conclusion. Extract ethanolic of berenuk fruit on A. salina had cytotoxic activity.
{"title":"Cytotoxic Activity Test Of Ethanolic Extract Of Berenuk Fruit (Crescentia Cujete L.) On Artemia Salina Leach Shrimp Larva Using Brine Shrimp Lethality Test (BSLT) Method","authors":"None Dona Suzana, Isnani Handayanti","doi":"10.32539/bji.v9i1.123","DOIUrl":"https://doi.org/10.32539/bji.v9i1.123","url":null,"abstract":"Introduction. Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy which has cytotoxic effects. One of the plants that have the same effect is the berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae, which grows wild and is often referred to as a poisonous plant. However, some people traditionally use this plant as a medicinal plant such as for antifungal, anthelmintic, analgesic, and anti-inflammatory. This plant contains naphthoquinones as one of the cytotoxic chemical compounds and another metabolite secondary such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. Methods. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larva that has been prepared and the value of mortality was observed. Results. The result of the cytotoxic activity test of ethanolic extract of berenuk fruit on A. salina larva had the LC50 value of 529.386 ppm which is categorized as toxic. Conclusion. Extract ethanolic of berenuk fruit on A. salina had cytotoxic activity.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The percentage of body fat is a component of body composition in addition to bone mass, muscle mass, and body water content related to obesity. Diseases caused by an increase in body fat will have an impact on decreasing the body's functional capacity, disability, and death. Maximum Oxygen Volume (VO2 max) refers to the maximum amount of oxygen that humans can use during physical activity. It is usually used to test aerobic endurance or cardiovascular fitness so that VO2 max can describe a person's functional capacity. Percentage of body fat can affect VO2 max. Based on data from the Sports Development Index (SDI) in Indonesia, 43.9% of young adults have a poor VO2 max. This study aims to determine whether or not there is a relationship between body fat percentage and functional capacity in young adults. Methods. The study used a cross-sectional method and was followed by 92 respondents throughout October and November 2022. Bioelectrical Impedance Analysis (BIA) is used to measure body fat percentage. The 6-minute Walk Test is used to measure VO2 max. Results. The results of the study showed that the bivariate analysis of the Fisher's Exact test obtained a significant relationship between body fat percentage (measured by BIA) and body functional capacity (VO2 max) (p=0.028). Conclusion. There was a significant relationship between body fat percentage through BIA measurements and functional capacity in young adults.
{"title":"Percentage Of Body Fat Related With Functional Capacity In Young Adults","authors":"Delia Ainnaya, Mustika Anggiane Putri","doi":"10.32539/bji.v9i1.159","DOIUrl":"https://doi.org/10.32539/bji.v9i1.159","url":null,"abstract":"Introduction. The percentage of body fat is a component of body composition in addition to bone mass, muscle mass, and body water content related to obesity. Diseases caused by an increase in body fat will have an impact on decreasing the body's functional capacity, disability, and death. Maximum Oxygen Volume (VO2 max) refers to the maximum amount of oxygen that humans can use during physical activity. It is usually used to test aerobic endurance or cardiovascular fitness so that VO2 max can describe a person's functional capacity. Percentage of body fat can affect VO2 max. Based on data from the Sports Development Index (SDI) in Indonesia, 43.9% of young adults have a poor VO2 max. This study aims to determine whether or not there is a relationship between body fat percentage and functional capacity in young adults. Methods. The study used a cross-sectional method and was followed by 92 respondents throughout October and November 2022. Bioelectrical Impedance Analysis (BIA) is used to measure body fat percentage. The 6-minute Walk Test is used to measure VO2 max. Results. The results of the study showed that the bivariate analysis of the Fisher's Exact test obtained a significant relationship between body fat percentage (measured by BIA) and body functional capacity (VO2 max) (p=0.028). Conclusion. There was a significant relationship between body fat percentage through BIA measurements and functional capacity in young adults.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Head injury is one of trauma cases with high morbidity and mortality, with an incidence of 7.3 to 811 cases per 100.000 individuals per year and mortality ratio varying from 5.2 to 80.73 cases per 100.000 cases. Calvaria fractures that result from head injuries are often associated with risk of post-traumatic morbidity and mortality, where the incidence of post-trauma calvaria fractures is about 25% of all cases and around 10% of calvaria fractures are depressed calvaria fractures. This study was aimed to identify the characteristics of patients with depressed calvaria fractures at Dr. Kariadi General Hospital in 2020. Methods. This research is a descriptive study using secondary data from medical records. There were 30 patients with depressed calvaria fractures in January - December 2020 at Dr. Kariadi Hospital. The data is then presented in tabular form. Results. Depressed calvaria fractures in the period 2020 at Dr. Kariadi General Hospital was dominated by male (76.7%), mainly age 12-45 years old with a mean of 25.73 years old. The most common cause of depressed calvaria fractures is high velocity trauma. Minor head injury is the most common type of head injury. Depressed calvaria fractures of the frontal bone predominate in 80% of cases, with fracture depth > 1 tabula. Conclusion: There were no cases of posttraumatic infection. There were 16.7% of cases with neurological deficits at the time of discharge. There were 73.3% cases with other intracranial disorders associated with depressed calvaria fractures. Operative management is the main choice of management with most cases length of stay are 5-10 days.
{"title":"Characteristics of Calvaria Depression Fractures Patients in Dr. Kariadi General Hospital, Semarang","authors":"Tan Hengky, Setya Budi Azhar","doi":"10.32539/bji.v7i2.524","DOIUrl":"https://doi.org/10.32539/bji.v7i2.524","url":null,"abstract":"Introduction. Head injury is one of trauma cases with high morbidity and mortality,\u0000with an incidence of 7.3 to 811 cases per 100.000 individuals per year and mortality\u0000ratio varying from 5.2 to 80.73 cases per 100.000 cases. Calvaria fractures that result\u0000from head injuries are often associated with risk of post-traumatic morbidity and\u0000mortality, where the incidence of post-trauma calvaria fractures is about 25% of all\u0000cases and around 10% of calvaria fractures are depressed calvaria fractures. This\u0000study was aimed to identify the characteristics of patients with depressed calvaria\u0000fractures at Dr. Kariadi General Hospital in 2020. Methods. This research is a\u0000descriptive study using secondary data from medical records. There were 30 patients\u0000with depressed calvaria fractures in January - December 2020 at Dr. Kariadi Hospital.\u0000The data is then presented in tabular form. Results. Depressed calvaria fractures in\u0000the period 2020 at Dr. Kariadi General Hospital was dominated by male (76.7%),\u0000mainly age 12-45 years old with a mean of 25.73 years old. The most common cause\u0000of depressed calvaria fractures is high velocity trauma. Minor head injury is the most\u0000common type of head injury. Depressed calvaria fractures of the frontal bone\u0000predominate in 80% of cases, with fracture depth > 1 tabula. Conclusion: There were\u0000no cases of posttraumatic infection. There were 16.7% of cases with neurological\u0000deficits at the time of discharge. There were 73.3% cases with other intracranial\u0000disorders associated with depressed calvaria fractures. Operative management is the\u0000main choice of management with most cases length of stay are 5-10 days.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76726050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The laboratory rat is an inevitable part of today's biomedical research. They arerecognized as the preeminent model in numerous fields, including neurobehavioralstudies, cancer and toxicology. It is difficult to evaluate the number of animalsemployed in scientific experiments every year. An estimation suggests some dozensof millions per year, being 15 million in the United States, 11 million in Europe, fivemillion in Japan, two million in Canada and less than one million in Australia.Almost 80% of the experimental animals are rodents that include mice, rats, guineapigs and others (10% are fish, amphibians, reptiles and birds). A third group includesrabbits, goats, bulls and in smaller amounts, dogs, cats and some species ofprimatess.
{"title":"Animal Model Rats Related Ages with Human’s in Biomedical Research","authors":"R. Hidayat, Patricia Wulandari","doi":"10.32539/BJI.V7I2.286","DOIUrl":"https://doi.org/10.32539/BJI.V7I2.286","url":null,"abstract":"The laboratory rat is an inevitable part of today's biomedical research. They arerecognized as the preeminent model in numerous fields, including neurobehavioralstudies, cancer and toxicology. It is difficult to evaluate the number of animalsemployed in scientific experiments every year. An estimation suggests some dozensof millions per year, being 15 million in the United States, 11 million in Europe, fivemillion in Japan, two million in Canada and less than one million in Australia.Almost 80% of the experimental animals are rodents that include mice, rats, guineapigs and others (10% are fish, amphibians, reptiles and birds). A third group includesrabbits, goats, bulls and in smaller amounts, dogs, cats and some species ofprimatess.","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"29 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79374201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Yulizal, Windi Anggriani, Stella Retta Marina, Ayu hasanah
Background Bangun-bangun leaves (Plectranthus amboinicus) are part of theLamiaceae family. (1) (1) Bangun-bangun leaves have a characteristic aromatic leavesaroma used as a medicinal plant (2). According to research conducted by (Dalimuntheet al., 2016) to find the use of this plant as an antibacterial because it containscompounds such as flavonoids, tannins, tripenoids, saponins, and essential oils. Onthe bangun-bangun leaves there is carvacrol, which is an essential component that hasantibacterial activity in positive or negative gram bacteria. streptococcus pyogenesbacteria are vectors of suppurative infectious diseases and other diseases such aspharyngitis. While salmonella typhi bacteria is a vector of the disease which is usuallycalled typhus and the medical language is typhoid fever. The purpose of this study wasto determine that the bacteria salmonella typhi and streptococcus pyogenens can beinhibited by the leaves extract. The benefit of this research is to increase publicunderstanding and knowledge in the use of bangun-bangun leaves. The method usedin this study is an experimental method and post test only controlled group design. Forthe concentration used, namely 5%, 10%, 15%, 20%, 25% and this strength test is doneby inserting the extract into a petri dish that has a bacterial culture. Data processinguses one-way ANOVA with the aim of comparing each variable. To see the extractagainst bacteria. The results showed that there were variations in the diameter of theinhibition zone formed by the concentration of the extract. And the most effectiveconcentration to inhibit streptococcus pyogenes bacteria was a concentration of 25%,the inhibition zone diameter was 19.5mm, while salmonella typhi bacteria had aconcentration of 25% and the inhibition zone diameter was 37.7m
{"title":"The Effectiveness Test of Bangun-Bangun Leaves Extract (Plecthranthus Ambonicus) Against Streptococcus Pyogenes and Salmonella Typhi Bacteria","authors":"O. Yulizal, Windi Anggriani, Stella Retta Marina, Ayu hasanah","doi":"10.32539/bji.v6i3.240","DOIUrl":"https://doi.org/10.32539/bji.v6i3.240","url":null,"abstract":"Background Bangun-bangun leaves (Plectranthus amboinicus) are part of theLamiaceae family. (1) (1) Bangun-bangun leaves have a characteristic aromatic leavesaroma used as a medicinal plant (2). According to research conducted by (Dalimuntheet al., 2016) to find the use of this plant as an antibacterial because it containscompounds such as flavonoids, tannins, tripenoids, saponins, and essential oils. Onthe bangun-bangun leaves there is carvacrol, which is an essential component that hasantibacterial activity in positive or negative gram bacteria. streptococcus pyogenesbacteria are vectors of suppurative infectious diseases and other diseases such aspharyngitis. While salmonella typhi bacteria is a vector of the disease which is usuallycalled typhus and the medical language is typhoid fever. The purpose of this study wasto determine that the bacteria salmonella typhi and streptococcus pyogenens can beinhibited by the leaves extract. The benefit of this research is to increase publicunderstanding and knowledge in the use of bangun-bangun leaves. The method usedin this study is an experimental method and post test only controlled group design. Forthe concentration used, namely 5%, 10%, 15%, 20%, 25% and this strength test is doneby inserting the extract into a petri dish that has a bacterial culture. Data processinguses one-way ANOVA with the aim of comparing each variable. To see the extractagainst bacteria. The results showed that there were variations in the diameter of theinhibition zone formed by the concentration of the extract. And the most effectiveconcentration to inhibit streptococcus pyogenes bacteria was a concentration of 25%,the inhibition zone diameter was 19.5mm, while salmonella typhi bacteria had aconcentration of 25% and the inhibition zone diameter was 37.7m","PeriodicalId":52711,"journal":{"name":"Biomedical Journal of Indonesia","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81333377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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