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Glucagon-like peptide-1 receptor agonists in total joint arthroplasty: a comprehensive systematic review of what orthopaedic surgeons should know. 胰高血糖素样肽-1受体激动剂在全关节置换术中的应用:骨科医生应了解的全面系统综述。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-23 DOI: 10.1186/s42836-026-00375-w
Omar Abdelaziz, Ziad G Zayed, Mohamed Abdo Khalafallah, Mohamed A Hanafy, Abdalla M Hadhoud, Khaled A Elmenawi
<p><strong>Background: </strong>The rising prevalence of obesity and type 2 diabetes mellitus (T2DM) among patients undergoing total joint arthroplasty (TJA) presents a significant clinical challenge, increasing the risk of postoperative complications. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a potential perioperative optimization strategy, but their impact on TJA outcomes remains debated. This systematic review was conducted to synthesize the evidence on the risks and benefits of GLP-1 RA use in adult patients undergoing primary TJA-specifically, total hip arthroplasty (THA), total knee arthroplasty (TKA), and total shoulder arthroplasty (TSA).</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed, Scopus, and Web of Science databases were searched from their inception to June 16, 2025, for studies comparing postoperative outcomes in adult patients undergoing primary total joint arthroplasty (TJA) and using GLP-1 RAs versus a control group. Data on study characteristics, patient demographics, and postoperative outcomes were extracted. Due to significant heterogeneity and overlap in data sources, a narrative synthesis rather than meta-analysis of the findings was conducted. Study quality was assessed using the Newcastle-Ottawa Scale (NOS).</p><p><strong>Results: </strong>Fifteen retrospective cohort studies involving an aggregate total of 318,143 patients (114,365 THA, 125,505 TKA, 78,273 TSA) were included, with 56,132 receiving GLP-1 RAs. In THA and TKA, GLP-1 RAs use was associated with a reduced risk of periprosthetic joint infection (PJI) (e.g., 1.6% vs. 2.9% at 2 years for THA) and lower 90-day readmission rates (e.g., 1.1% vs. 2.0% for TKA and 1.6% vs. 2.0% for THA). When analyzed by exposure timing, the reduced PJI risk was most consistent in studies that defined GLP-1 RA use in the immediate perioperative period. Reported mean length of stay (LOS) was generally similar or slightly shorter among GLP-1 RA users compared to controls. Multiple studies reported either a reduction or no significant difference in the risk of 90-day emergency department visits. The short-term revision rates and dislocations were infrequent and did not differ significantly between groups in most of the included studies. In the TSA, evidence was inconsistent, with reduced odds of 90-day surgical site infection (SSI) (OR 0.25) in one study; however, no clear trend was observed. Gastrointestinal side effects and conflicting systemic risks were noted across procedures.</p><p><strong>Conclusion: </strong>Current observational data suggest that perioperative GLP-1 RA use in patients undergoing total hip or knee arthroplasty is not associated with a consistent increase in short-term revision rates and may be associated with a reduced risk of postoperative infection. Evidence regarding TSA remains inconclusive.
背景:在接受全关节置换术(TJA)的患者中,肥胖和2型糖尿病(T2DM)的患病率不断上升,这给临床带来了重大挑战,增加了术后并发症的风险。胰高血糖素样肽-1受体激动剂(GLP-1 RAs)已成为围手术期潜在的优化策略,但其对TJA预后的影响仍存在争议。本系统综述旨在综合GLP-1 RA用于原发性tja(特别是全髋关节置换术(THA)、全膝关节置换术(TKA)和全肩关节置换术(TSA)的成年患者的风险和益处的证据。方法:按照系统评价和荟萃分析的首选报告项目(PRISMA)指南进行系统评价。我们从PubMed、Scopus和Web of Science数据库开始到2025年6月16日进行了检索,以比较接受原发性全关节置换术(TJA)和使用GLP-1 RAs的成人患者与对照组的术后结果。提取有关研究特征、患者人口统计学和术后结果的数据。由于数据来源存在显著的异质性和重叠,因此对研究结果进行了叙述性综合而不是元分析。采用纽卡斯尔-渥太华量表(NOS)评估研究质量。结果:15项回顾性队列研究共纳入318,143例患者(114,365例THA, 125,505例TKA, 78,273例TSA),其中56,132例接受GLP-1 RAs治疗。在THA和TKA中,GLP-1 RAs的使用与假体周围关节感染(PJI)的风险降低(例如,2年THA为1.6%对2.9%)和90天再入院率降低相关(例如,TKA为1.1%对2.0%,THA为1.6%对2.0%)。当通过暴露时间进行分析时,在确定GLP-1 RA即刻围手术期使用的研究中,PJI风险的降低是最一致的。与对照组相比,GLP-1 RA使用者报告的平均停留时间(LOS)大致相似或略短。多项研究报告,90天急诊科就诊的风险降低或无显著差异。在大多数纳入的研究中,短期翻修率和脱位并不常见,组间无显著差异。在TSA中,证据不一致,在一项研究中,90天手术部位感染(SSI)的几率降低(OR 0.25);然而,没有观察到明显的趋势。在整个过程中注意到胃肠道副作用和相互冲突的系统性风险。结论:目前的观察数据表明,在全髋关节或膝关节置换术患者围手术期使用GLP-1 RA与短期翻修率的持续增加无关,可能与术后感染风险的降低有关。关于运输安全管理局的证据仍然没有定论。然而,考虑到证据的回顾性、数据来源的大量重叠、暴露定义的异质性以及短期随访,这些发现应被视为假设生成。未来需要有标准化暴露定义的前瞻性随机对照试验和更长的随访来证实这些关联并确定因果关系。
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引用次数: 0
A tribute to our reviewers: Arthroplasty 2025 review and future outlook. 向我们的审稿人致敬:关节成形术2025回顾和未来展望。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-16 DOI: 10.1186/s42836-026-00378-7
Yan Wang
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引用次数: 0
Safety and efficacy of day-case hip and knee arthroplasty in the NHS: a nationwide UK cohort study. 在英国国家医疗服务体系中,一日髋关节和膝关节置换术的安全性和有效性:一项全国性的英国队列研究。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-13 DOI: 10.1186/s42836-026-00377-8
Omar Musbahi, Ahmed Al-Saadawi, Saran Singh Gill, Sara Sousi, Alex Bottle, Justin P Cobb, Gareth G Jones

Introduction: In recent years, day-case hip and knee arthroplasty has emerged as a potential solution to the elective backlog within the NHS. While international literature on this topic is extensive, only a handful of single-centre studies have been conducted in the United Kingdom. This study aimed to examine the safety and efficacy of day-case hip and knee arthroplasty in the UK using a 20-year linked national NHS dataset.

Methods: A cohort study was conducted using the Clinical Practice Research Datalink (CPRD), linked to Hospital Episode Statistics (HES) and the Office for National Statistics death registry. Adults undergoing primary hip or knee arthroplasty between 1998 and 2021 were included. Procedures were classified as day-case or inpatient, using two distinct approaches: patient classification and length of stay. Day-case is defined as discharge on the same day of the procedure, while inpatient procedures involve undergo at least one overnight stay in hospital. The primary outcomes assessed were A&E attendance, readmission, and critical care admission within 90-days post-operatively. Secondary outcomes included 90-day complication rates and survival analysis. Propensity score matching was implemented to adjust outcomes for age, gender, comorbidity burden, deprivation index, and ethnicity.

Results: In total, 1,822 (0.16%) procedures were classified as day-case, while 4,355 (0.37%) had a recorded length of stay of 0 days. On average, patients undergoing day-case arthroplasty were younger, more often male, and had fewer comorbidities than their inpatient counterparts. Higher rates of A&E attendance (12% vs 9.1%; P = 0.001) and readmission (5.7% vs 3.7%; P < 0.001) were observed in the day-case cohort. In contrast, deep vein thrombosis (0.5% vs 0.9%; P = 0.010) and infection rates (1.0% vs 1.9%; P = 0.014) were lower in this patient group. Survival analyses demonstrated significantly higher adjusted survival probabilities associated with day-case arthroplasty (HR: 0.84; [95% CI: 0.72-0.99]; P = 0.034) over a 20-year follow-up period.

Conclusion: Day-case hip and knee arthroplasty has been demonstrated to be  safe and feasible, with comparable complication rates to the traditional inpatient setting. However, within the context of the NHS, it is currently associated with higher rates of 90-day A&E attendance and readmission. While increasing day-case volumes may help address elective backlogs, it is important to ensure that the appropriate patient selection criteria, optimised peri-operative care, and post-discharge support are in place before this approach is expanded in the UK.

简介:近年来,髋关节和膝关节置换术已成为NHS内选择性积压的潜在解决方案。虽然关于这一主题的国际文献非常广泛,但在英国只有少数的单中心研究。本研究旨在使用20年的国家NHS数据集来检查英国单日髋关节和膝关节置换术的安全性和有效性。方法:使用临床实践研究数据链(CPRD)进行队列研究,该数据链与医院事件统计(HES)和国家统计局死亡登记相关联。纳入了1998年至2021年间接受髋关节或膝关节置换术的成年人。程序分为日间病例或住院,使用两种不同的方法:患者分类和住院时间。日间病例的定义是在手术当天出院,而住院患者的定义是至少在医院住一晚。评估的主要结局是术后90天内急诊出勤、再入院和重症监护入院。次要结局包括90天并发症发生率和生存分析。采用倾向评分匹配来调整年龄、性别、合并症负担、剥夺指数和种族的结果。结果:日间病例1822例(0.16%),住院天数为0天的病例4355例(0.37%)。平均而言,接受日间关节置换术的患者更年轻,更多的是男性,并且比住院患者的合并症更少。更高的急诊率(12% vs 9.1%; P = 0.001)和再入院率(5.7% vs 3.7%; P)结论:一天一次的髋关节和膝关节置换术已被证明是安全可行的,并发症发生率与传统住院情况相当。然而,在NHS的背景下,它目前与90天急症室出勤率和再入院率较高有关。虽然增加日病例量可能有助于解决选择性积压问题,但重要的是要确保适当的患者选择标准、优化的围手术期护理和出院后支持在这种方法在英国推广之前到位。
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引用次数: 0
Medial femoral condyle restoration technique in total knee arthroplasty. 全膝关节置换术中股骨内侧髁复位技术。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-11 DOI: 10.1186/s42836-025-00353-8
Quanbo Ji, Yan Wang, Lin Hao, Yang Luo, Peng Ren, Ming Ni, Lei Geng, Guoqiang Zhang

Objective: To introduce a medial femoral condyle restoration (MFCR) technique for total knee arthroplasty (TKA) and compare its clinical outcomes with conventional mechanical alignment (MA) in varus osteoarthritis.

Methods: In this prospective randomized trial, 126 consecutive patients with varus osteoarthritis undergoing TKA (January 2021-January 2023) were assigned to MFCR or MA. MFCR surgical key points were medially focused quantitative compensation of cartilage loss by reducing distal/posterior medial femoral resections using thickness-specific shims (0.5-2.0 mm, 0.5-mm steps) guided by Outerbridge grading and calibrated probing. Participants were randomized to receive either the MFCR technique or the conventional MA technique. Intraoperative outcomes (blood loss, operative time, hospital stay, and medial release) and postoperative ROM were recorded; functional outcomes included WOMAC and walking VAS pain. Continuous variables were expressed as mean ± standard deviation and analyzed using one-way analysis of variance.

Results: The mean age of the MFCR group and control group was 68.3 ± 7.4 years and 67.9 ± 8.7 years, respectively (P = 0.4236). Preoperatively, the mean WOMAC score of the groups was 67.2 ± 9.8 and 62.3 ± 16.4, respectively (P = 0.2524). The mean varus knee angle was 18.2° ± 7.2° and 17.3° ± 8.9°, respectively (P = 0.6735). The mean time for soft tissue balancing was 5.1 ± 2.6 min and 12.1 ± 4.3 min in the MFCR and control group, respectively (P = 0.017). The mean operative time was 50.6 ± 12.1 min and 58.9 ± 13.8 min in the MFCR and control group, respectively (P = 0.011). The mean hospital stay time was 1.8 ± 0.7 days and 3.2 ± 0.9 days in the MFCR and control group, respectively (P = 0.028). At 2 years postoperatively, the WOMAC scores were 29.9 ± 17.9 and 43.6 ± 13.7, respectively (P = 0.0325). Postoperative nausea/vomiting occurred less frequently in the MFCR group (P = 0.0391), with no other complications observed during follow-up.

Conclusion: MFCR restored the anatomy of the medial femoral condyle by quantitatively preserving medial femoral bone to compensate for cartilage loss within a bony-first, minimal-release workflow. Compared with MA, MFCR reduced perioperative burden and improved early function, and can be implemented using a simple, reproducible technique without advanced imaging or robotics. Video Abstract.

目的:介绍全膝关节置换术(TKA)中股骨内侧髁复位(MFCR)技术,并比较其与常规机械对准(MA)治疗内翻性骨关节炎的临床效果。方法:在这项前瞻性随机试验中,126例连续接受TKA的内翻性骨关节炎患者(2021年1月至2023年1月)被分配到MFCR或MA组。MFCR手术要点是在Outerbridge分级和校准探针的指导下,通过厚度特异性垫片(0.5-2.0 mm, 0.5 mm步)减少股骨远端/后内侧切除术,以内侧聚焦软骨损失的定量补偿。参与者随机接受MFCR技术或传统MA技术。记录术中结果(出血量、手术时间、住院时间和出院时间)和术后ROM;功能结果包括WOMAC和行走VAS疼痛。连续变量以均数±标准差表示,采用单因素方差分析。结果:MFCR组和对照组的平均年龄分别为68.3±7.4岁和67.9±8.7岁(P = 0.4236)。术前,两组患者的平均WOMAC评分分别为67.2±9.8分和62.3±16.4分(P = 0.2524)。平均膝内翻角度分别为18.2°±7.2°和17.3°±8.9°(P = 0.6735)。MFCR组和对照组的平均软组织平衡时间分别为5.1±2.6 min和12.1±4.3 min (P = 0.017)。MFCR组和对照组的平均手术时间分别为50.6±12.1 min和58.9±13.8 min (P = 0.011)。MFCR组和对照组的平均住院时间分别为1.8±0.7 d和3.2±0.9 d (P = 0.028)。术后2年WOMAC评分分别为29.9±17.9分和43.6±13.7分(P = 0.0325)。MFCR组术后恶心/呕吐发生率较低(P = 0.0391),随访期间未见其他并发症。结论:MFCR通过定量保留股骨内侧骨来补偿骨优先、最小释放工作流程中的软骨损失,从而恢复了股骨内侧髁的解剖结构。与MA相比,MFCR减轻了围手术期负担,改善了早期功能,并且可以使用简单,可重复的技术实施,无需先进的成像或机器人技术。视频摘要。
{"title":"Medial femoral condyle restoration technique in total knee arthroplasty.","authors":"Quanbo Ji, Yan Wang, Lin Hao, Yang Luo, Peng Ren, Ming Ni, Lei Geng, Guoqiang Zhang","doi":"10.1186/s42836-025-00353-8","DOIUrl":"10.1186/s42836-025-00353-8","url":null,"abstract":"<p><strong>Objective: </strong>To introduce a medial femoral condyle restoration (MFCR) technique for total knee arthroplasty (TKA) and compare its clinical outcomes with conventional mechanical alignment (MA) in varus osteoarthritis.</p><p><strong>Methods: </strong>In this prospective randomized trial, 126 consecutive patients with varus osteoarthritis undergoing TKA (January 2021-January 2023) were assigned to MFCR or MA. MFCR surgical key points were medially focused quantitative compensation of cartilage loss by reducing distal/posterior medial femoral resections using thickness-specific shims (0.5-2.0 mm, 0.5-mm steps) guided by Outerbridge grading and calibrated probing. Participants were randomized to receive either the MFCR technique or the conventional MA technique. Intraoperative outcomes (blood loss, operative time, hospital stay, and medial release) and postoperative ROM were recorded; functional outcomes included WOMAC and walking VAS pain. Continuous variables were expressed as mean ± standard deviation and analyzed using one-way analysis of variance.</p><p><strong>Results: </strong>The mean age of the MFCR group and control group was 68.3 ± 7.4 years and 67.9 ± 8.7 years, respectively (P = 0.4236). Preoperatively, the mean WOMAC score of the groups was 67.2 ± 9.8 and 62.3 ± 16.4, respectively (P = 0.2524). The mean varus knee angle was 18.2° ± 7.2° and 17.3° ± 8.9°, respectively (P = 0.6735). The mean time for soft tissue balancing was 5.1 ± 2.6 min and 12.1 ± 4.3 min in the MFCR and control group, respectively (P = 0.017). The mean operative time was 50.6 ± 12.1 min and 58.9 ± 13.8 min in the MFCR and control group, respectively (P = 0.011). The mean hospital stay time was 1.8 ± 0.7 days and 3.2 ± 0.9 days in the MFCR and control group, respectively (P = 0.028). At 2 years postoperatively, the WOMAC scores were 29.9 ± 17.9 and 43.6 ± 13.7, respectively (P = 0.0325). Postoperative nausea/vomiting occurred less frequently in the MFCR group (P = 0.0391), with no other complications observed during follow-up.</p><p><strong>Conclusion: </strong>MFCR restored the anatomy of the medial femoral condyle by quantitatively preserving medial femoral bone to compensate for cartilage loss within a bony-first, minimal-release workflow. Compared with MA, MFCR reduced perioperative burden and improved early function, and can be implemented using a simple, reproducible technique without advanced imaging or robotics. Video Abstract.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"8 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk analysis index demonstrates superior predictive performance compared to traditional frailty metrics in elderly female patients undergoing inpatient total shoulder arthroplasty. 与传统的衰弱指标相比,风险分析指数在接受住院全肩关节置换术的老年女性患者中显示出优越的预测性能。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-05 DOI: 10.1186/s42836-025-00366-3
Cameron J Sabet, Bhav Jain, Bara M Hammadeh, Abdulhalim Kikhia, Mohammad D Alfawareh

Background: While frailty assessment has become integral to preoperative risk stratification, the optimal measurement tool remains unclear for elderly women undergoing total shoulder arthroplasty (TSA). This study compared the predictive performance of the Risk Analysis Index (RAI) against traditional metrics, including the modified frailty index-5 (mFI-5) and Geriatric Nutritional Risk Index (GNRI) in this specific population.

Methods: We conducted a retrospective analysis of ACS NSQIP data from 2015-2021, including female patients aged 65-89 undergoing inpatient TSA. RAI incorporates age, functional status, recent weight loss, and physiological markers, including renal failure, congestive heart failure, and dyspnea. The mFI-5 assesses five comorbidities (diabetes, hypertension, COPD, heart failure, functional dependence), while the GNRI evaluates nutritional status using albumin and body weight. The discriminative ability of RAI, mFI-5, and GNRI was assessed using area under the curve (AUC) analysis for multiple 30-day outcomes. Primary outcomes were non-home discharge and extended length of stay (≥ 4 days), selected based on their clinical importance for discharge planning and quality metrics. Secondary outcomes included 30-day mortality, major and minor complications, readmission, and reoperation. Discriminative ability was assessed using area under the curve (AUC) analysis. Internal validation was performed using bootstrap resampling.

Results: Among 11,965 patients analyzed, RAI demonstrated superior predictive performance for primary outcomes with AUCs of 0.784 for non-home discharge and 0.670 for extended length of stay, significantly outperforming mFI-5 (AUCs 0.601 and 0.590, respectively) and GNRI (AUCs 0.544 and 0.543). For secondary outcomes, RAI maintained competitive performance across mortality, complications, readmissions, and reoperations.

Conclusion: The Risk Analysis Index provides superior discrimination for non-home discharge and extended length of stay compared to traditional frailty measures in elderly female TSA patients, with particularly strong predictive performance for discharge disposition, supporting its adoption as the preferred risk stratification tool for discharge planning in this population. Video Abstract.

背景:虽然衰弱评估已成为术前风险分层的组成部分,但对于接受全肩关节置换术(TSA)的老年妇女,最佳测量工具仍不清楚。本研究比较了风险分析指数(RAI)与传统指标的预测性能,包括改进的脆弱指数-5 (mFI-5)和老年营养风险指数(GNRI)在特定人群中的预测性能。方法:我们对2015-2021年ACS NSQIP数据进行回顾性分析,包括65-89岁住院TSA的女性患者。RAI包括年龄、功能状态、近期体重减轻和生理指标,包括肾功能衰竭、充血性心力衰竭和呼吸困难。mFI-5评估5种合并症(糖尿病、高血压、慢性阻塞性肺病、心力衰竭、功能依赖),而GNRI使用白蛋白和体重评估营养状况。采用多个30天预后的曲线下面积(AUC)分析评估RAI、mFI-5和GNRI的判别能力。主要结局为非居家出院和延长住院时间(≥4天),选择依据是其对出院计划和质量指标的临床重要性。次要结局包括30天死亡率、主要和次要并发症、再入院和再手术。采用曲线下面积(AUC)分析评价鉴别能力。内部验证使用自举重采样进行。结果:在分析的11,965例患者中,RAI对主要结局的预测性能优于mFI-5 (auc分别为0.601和0.590)和GNRI (auc分别为0.544和0.543),非家庭出院的auc为0.784,延长住院时间的auc为0.670。次要结局方面,RAI在死亡率、并发症、再入院和再手术方面保持了竞争力。结论:与传统的虚弱指标相比,风险分析指数对老年女性TSA患者的非居家出院和延长住院时间具有更好的区分能力,对出院处置的预测能力尤其强,支持将其作为该人群出院计划的首选风险分层工具。视频摘要。
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引用次数: 0
Anatomical relationship between the intertrochanteric line and femoral neck osteotomy level in direct anterior approach total hip arthroplasty: a 3D morphometric and cadaveric validation study. 直接前路全髋关节置换术中股骨粗隆间线与股骨颈截骨水平的解剖关系:三维形态学和尸体验证研究。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-03 DOI: 10.1186/s42836-025-00365-4
Sakkadech Limmahakhun, Suchate Runraksar, Nitchanant Kitcharanant, Warakorn Jingjit

Aims: Inaccurate femoral neck osteotomy is a recognized technical challenge in direct anterior approach total hip arthroplasty (DAA-THA), largely due to limited femoral exposure and the absence of a standardized intraoperative landmark. This study aimed to investigate whether the ITL is an alternative bony landmark for femoral neck osteotomy during the DAA.

Patients and methods: Three anatomical references, the Intertrochanteric line (ITL) height (ITL-H), ITL angle (ITL-A), and femoral saddle height (SH), were measured from 3D-CT models of 60 normal hip patients (30 males and 30 females) to simulate a cutting height of 10 mm above the LT. Twenty cadaveric hip specimens were then used to evaluate the accuracy of the proposed anatomical references.

Results: The mean ITL-H, ITL-A, and SH were 23 ± 4 mm, 17.4° ± 3.5°, and 26 ± 4 mm, respectively. While ITL-H showed no sex difference (23 ± 3.4 mm vs 23.1 ± 4.1 mm, P = 0.96), significant differences existed for ITL-A (15.8° ± 3.4° vs 19.9° ± 1.4°, P = 0.001) and SH (27.2 ± 3.9 mm vs 23.9 ± 3 mm, P = 0.002). ITL-H was not correlated with age (P = 0.063), femoral length (P = 0.31), or femoral neck shaft angle (P = 0.41). Femoral neck osteotomy performed 23 mm above the ITL-H could yield 80% and 100% success rates for cutting heights of 10-15 mm and > 5 mm above the LT, respectively.

Conclusions: ITL-H serves as a reproducible anatomical landmark for femoral neck osteotomy during DAA-THA. An osteotomy level of approximately 23 mm above the ITL-H represents a safe lower margin to avoid excessive calcar bone resection. Nevertheless, individualized preliminary osteotomy based on preoperative templating remains necessary, with intraoperative adjustment according to patient-specific ITL-H. Video Abstract.

目的:不准确的股骨颈截骨术是直接前路全髋关节置换术(DAA-THA)中公认的技术挑战,主要是由于股骨暴露有限和缺乏标准化的术中标记。本研究旨在探讨在DAA期间,ITL是否是股骨颈截骨术的替代骨标志。患者和方法:从60例正常髋关节患者(男性30例,女性30例)的3D-CT模型中测量三个解剖学参考点,即转子间线(ITL)高度(ITL- h)、ITL角(ITL- a)和股骨鞍高度(SH),以模拟lt10 mm以上的切割高度。然后使用20例尸体髋关节标本来评估所提出的解剖学参考点的准确性。结果:ITL-H、ITL-A、SH均值分别为23±4 mm、17.4°±3.5°、26±4 mm。ITL-H无性别差异(23±3.4 mm vs 23.1±4.1 mm, P = 0.96),但ITL-A(15.8°±3.4°vs 19.9°±1.4°,P = 0.001)和SH(27.2±3.9 mm vs 23.9±3 mm, P = 0.002)存在显著差异。ITL-H与年龄(P = 0.063)、股骨长度(P = 0.31)、股骨颈轴角(P = 0.41)无关。股骨颈截骨术在髂胫韧带上方23 mm处,切割高度分别为10-15 mm和50 - 5 mm,成功率分别为80%和100%。结论:在DAA-THA术中,ITL-H可作为股骨颈截骨术的可重复性解剖标志。截骨高度在ITL-H上方约23 mm代表安全的下缘,以避免过多的跟骨切除。然而,基于术前模板的个体化初步截骨术仍然是必要的,术中根据患者特定的il - h进行调整。视频摘要。
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引用次数: 0
Exploring the optimal age for total knee arthroplasty to minimize risk of adverse outcomes: machine learning analysis of a statewide cohort. 探索全膝关节置换术的最佳年龄,以尽量减少不良后果的风险:全州队列的机器学习分析。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-02-28 DOI: 10.1186/s42836-026-00372-z
Chloe Heiting, Yiyuan Wu, Susan M Goodman, Peter Sculco, Fei Wang, Said Ibrahim, Peter Cram, Rich Caruana, Bella Mehta

Background: Rates of total knee arthroplasty (TKA) in the United States have risen in patients of a wide age range. Although rates of postoperative TKA complications have decreased, they remain a significant concern. In this study, we aim to determine how the risk of adverse TKA outcomes changes dynamically with age and explore the optimal ages with the lowest risk for adverse outcomes.

Methods: This retrospective cohort study included patients who underwent elective primary TKA from 2012 to 2018 in the Pennsylvania Health Care Cost Containment Council Database. We trained (70% train:30% test) an explainable boosting machine (EBM), a modern generalized additive model, to predict risk for 90-day mortality, 90-day readmission, 1-year revision, and longer length of stay (LOS). This "glass box" model allowed us to measure and visualize feature importance using mean absolute scores and determine the role of age in the model. We then ran EBM models that allowed two-way interactions between age and patient-level covariates.

Results: In our cohort of 227,959 patients, 90-day readmission was observed in 7.5%, 90-day mortality in 0.2%, and 1-year revision in 0.8%. The median LOS was 2 days (IQR [2, 3]). Age was among the most important factors for predicting all outcomes, and these were nonlinear relationships. The risk for 90-day mortality increased substantially at 76.5 years, and for 90-day readmission and longer LOS at 73.5 years. Risk for 1-year revision was greater before 63.5 years.

Conclusions: We determined that there is a nonlinear relationship between age and risk for adverse TKA outcomes, and it changes dramatically at specific time points. Our data suggests that the optimal age for lower risk of 90-day mortality, 90-day readmission, and longer LOS is below 73.5 years, and above 63.5 years for 1-year revision. These findings can help in decision-making when trying to quantify risks related to aging.

背景:在美国,全膝关节置换术(TKA)的比例在各个年龄段的患者中都有所上升。虽然术后TKA并发症的发生率已经下降,但它们仍然是一个值得关注的问题。在本研究中,我们旨在确定TKA不良结局的风险如何随年龄的变化而动态变化,并探索不良结局风险最低的最佳年龄。方法:本回顾性队列研究纳入了宾夕法尼亚州卫生保健成本控制委员会数据库中2012年至2018年接受选择性原发性TKA的患者。我们训练(70%训练:30%测试)一个可解释的增强机(EBM),一个现代广义加性模型,来预测90天死亡率、90天再入院、1年翻修和更长的住院时间(LOS)的风险。这个“玻璃盒”模型允许我们使用平均绝对分数来测量和可视化特征的重要性,并确定年龄在模型中的作用。然后,我们运行EBM模型,允许年龄和患者水平协变量之间的双向交互。结果:在我们的227,959例患者队列中,90天再入院率为7.5%,90天死亡率为0.2%,1年复查率为0.8%。中位生存期为2天(IQR[2,3])。年龄是预测所有结果的最重要因素之一,而且这些都是非线性关系。90天死亡率的风险在76.5岁时显著增加,90天再入院和更长LOS的风险在73.5岁时显著增加。63.5岁前进行1年修订的风险更大。结论:我们确定年龄与不良TKA结局风险之间存在非线性关系,并且在特定时间点发生显著变化。我们的数据表明,降低90天死亡率、90天再入院风险和延长LOS的最佳年龄为73.5岁以下,1年翻修的最佳年龄为63.5岁以上。这些发现有助于在量化与衰老有关的风险时做出决策。
{"title":"Exploring the optimal age for total knee arthroplasty to minimize risk of adverse outcomes: machine learning analysis of a statewide cohort.","authors":"Chloe Heiting, Yiyuan Wu, Susan M Goodman, Peter Sculco, Fei Wang, Said Ibrahim, Peter Cram, Rich Caruana, Bella Mehta","doi":"10.1186/s42836-026-00372-z","DOIUrl":"10.1186/s42836-026-00372-z","url":null,"abstract":"<p><strong>Background: </strong>Rates of total knee arthroplasty (TKA) in the United States have risen in patients of a wide age range. Although rates of postoperative TKA complications have decreased, they remain a significant concern. In this study, we aim to determine how the risk of adverse TKA outcomes changes dynamically with age and explore the optimal ages with the lowest risk for adverse outcomes.</p><p><strong>Methods: </strong>This retrospective cohort study included patients who underwent elective primary TKA from 2012 to 2018 in the Pennsylvania Health Care Cost Containment Council Database. We trained (70% train:30% test) an explainable boosting machine (EBM), a modern generalized additive model, to predict risk for 90-day mortality, 90-day readmission, 1-year revision, and longer length of stay (LOS). This \"glass box\" model allowed us to measure and visualize feature importance using mean absolute scores and determine the role of age in the model. We then ran EBM models that allowed two-way interactions between age and patient-level covariates.</p><p><strong>Results: </strong>In our cohort of 227,959 patients, 90-day readmission was observed in 7.5%, 90-day mortality in 0.2%, and 1-year revision in 0.8%. The median LOS was 2 days (IQR [2, 3]). Age was among the most important factors for predicting all outcomes, and these were nonlinear relationships. The risk for 90-day mortality increased substantially at 76.5 years, and for 90-day readmission and longer LOS at 73.5 years. Risk for 1-year revision was greater before 63.5 years.</p><p><strong>Conclusions: </strong>We determined that there is a nonlinear relationship between age and risk for adverse TKA outcomes, and it changes dramatically at specific time points. Our data suggests that the optimal age for lower risk of 90-day mortality, 90-day readmission, and longer LOS is below 73.5 years, and above 63.5 years for 1-year revision. These findings can help in decision-making when trying to quantify risks related to aging.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"8 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National evidence linking robotic total knee arthroplasty to reduced 90-day readmissions, complications, and readmission costs. 国家证据表明,机器人全膝关节置换术可减少90天的再入院、并发症和再入院费用。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-02-28 DOI: 10.1186/s42836-026-00373-y
David Maman, Yaniv Steinfeld, Yaron Berkovich

Purpose: To compare 90-day readmissions, complications, and resource use after robotic-assisted versus conventional total knee arthroplasty (TKA) in a contemporary, nationally representative cohort.

Methods: Retrospective cohort study using the Nationwide Readmissions Database (NRD) 2020-2022. Primary TKA identified from the PR1 field (ICD-10-PCS). Exclusions included non-elective admissions, revisions, bilateral procedures, age < 18, oncology/fracture/reoperation, COVID-19, and discharges after September. Readmissions within 90 days were categorized (prosthesis/SSI, mechanical/implant, VTE). 1:1 propensity score matching (nearest neighbor, caliper 0.01, no replacement) included demographics, comorbidities, hospital factors, and year.

Results: After matching, 96,982 patients (48,491 per group) were analyzed. Robotic TKA showed lower all-cause 90-day readmission (5.0% vs 6.5%), superior readmission-free survival (log-rank P < 0.001), shorter readmission LOS (4.8 vs 5.6 days), and lower readmission charges ($66,769 vs $75,544), with slightly higher index charges ($78,125 vs $74,090). Risks were lower for VTE/PE, pneumonia, transfusion, postoperative pain, and prosthesis/SSI-related and mechanical readmissions.

Conclusions: In the largest contemporary national analysis, robotic TKA was associated with fewer early complications, lower 90-day readmissions, and reduced readmission resource use compared with conventional TKA.

目的:比较机器人辅助与传统全膝关节置换术(TKA)后90天的再入院、并发症和资源使用情况。方法:使用2020-2022年全国再入院数据库(NRD)进行回顾性队列研究。从PR1字段(ICD-10-PCS)中识别的主TKA。排除包括非选择性入院、翻修、双侧手术、年龄。结果:匹配后,分析了96,982例患者(每组48,491例)。结论:在当代最大的国家分析中,与传统TKA相比,机器人TKA与更少的早期并发症、更低的90天再入院率和更少的再入院资源使用相关。
{"title":"National evidence linking robotic total knee arthroplasty to reduced 90-day readmissions, complications, and readmission costs.","authors":"David Maman, Yaniv Steinfeld, Yaron Berkovich","doi":"10.1186/s42836-026-00373-y","DOIUrl":"10.1186/s42836-026-00373-y","url":null,"abstract":"<p><strong>Purpose: </strong>To compare 90-day readmissions, complications, and resource use after robotic-assisted versus conventional total knee arthroplasty (TKA) in a contemporary, nationally representative cohort.</p><p><strong>Methods: </strong>Retrospective cohort study using the Nationwide Readmissions Database (NRD) 2020-2022. Primary TKA identified from the PR1 field (ICD-10-PCS). Exclusions included non-elective admissions, revisions, bilateral procedures, age < 18, oncology/fracture/reoperation, COVID-19, and discharges after September. Readmissions within 90 days were categorized (prosthesis/SSI, mechanical/implant, VTE). 1:1 propensity score matching (nearest neighbor, caliper 0.01, no replacement) included demographics, comorbidities, hospital factors, and year.</p><p><strong>Results: </strong>After matching, 96,982 patients (48,491 per group) were analyzed. Robotic TKA showed lower all-cause 90-day readmission (5.0% vs 6.5%), superior readmission-free survival (log-rank P < 0.001), shorter readmission LOS (4.8 vs 5.6 days), and lower readmission charges ($66,769 vs $75,544), with slightly higher index charges ($78,125 vs $74,090). Risks were lower for VTE/PE, pneumonia, transfusion, postoperative pain, and prosthesis/SSI-related and mechanical readmissions.</p><p><strong>Conclusions: </strong>In the largest contemporary national analysis, robotic TKA was associated with fewer early complications, lower 90-day readmissions, and reduced readmission resource use compared with conventional TKA.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"8 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restricted kinematic alignment total knee arthroplasty using augmented reality technology to maintain limb alignment within targeted boundaries. 利用增强现实技术进行受限运动对齐全膝关节置换术,使肢体在目标边界内保持对齐。
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-02-28 DOI: 10.1186/s42836-026-00371-0
Sachiyuki Tsukada, Hiroyuki Ogawa, Tsutomu Nakayama, Shiho Minami, Masayoshi Saito, Naoyuki Hirasawa

Background: An augmented reality (AR)-aided navigation system that utilizes a standard smartphone enables accurate alignment of femoral and tibial components in total knee arthroplasty (TKA) and provides real-time intraoperative quantification of joint gaps. This study aimed to integrate the AR-aided navigation system into the surgical technique of restricted kinematic alignment and to evaluate its clinical effectiveness.

Methods: We compared 45 restricted kinematic alignment TKAs performed using posterior cruciate ligament (PCL) retaining medial-congruent prosthesis with an AR-aided navigation system and 40 mechanically aligned TKAs performed using PCL resecting posterior-stabilized prosthesis in patients with preoperative varus or neutral lower limb alignment. In the restricted kinematic alignment group, femoral and tibial alignments were determined using calipered and soft tissue-guided techniques, respectively, with the AR-aided navigation system providing real-time confirmation that angular values remained within safe boundaries. The target intraoperative extension gap was a rectangular configuration with equal medial and lateral widths.

Results: Intraoperative measured value of the soft-tissue imbalance with the knee in extension was significantly smaller in the restricted kinematic alignment group than in the mechanical alignment group (1.1 ± 1.1° vs 2.5 ± 2.2°; 95% CI, 0.7 to 2.2°; P < 0.001; Cohen's d = 0.85). After propensity score matching, no significant differences were observed between the groups in either the timed up-and-go test or the 10-m walk test at 1 week postoperatively (12.6 ± 3.5 s vs 13.2 ± 5.3 s; 95% CI, - 3.0 to 1.7; P = 0.60; and 11.7 ± 2.5 s vs 11.9 ± 3.2 s; 95% CI, - 1.7 to 1.3; P = 0.82, respectively).

Conclusions: Restricted kinematic alignment TKA using PCL retaining medial-congruent prosthesis achieved more balanced intraoperative soft-tissue tension than the mechanical alignment TKA using posterior-stabilized prosthesis. However, early postoperative walking speed did not differ between the two groups.

背景:一种利用标准智能手机的增强现实(AR)辅助导航系统可以在全膝关节置换术(TKA)中精确对准股骨和胫骨部件,并提供术中关节间隙的实时量化。本研究旨在将ar辅助导航系统整合到受限运动对齐的手术技术中,并评估其临床效果。方法:我们比较了术前内翻或中性下肢对准患者使用后交叉韧带(PCL)保留内侧一致假体与ar辅助导航系统进行的45例受限运动学对齐tka和使用PCL切除后稳定假体进行的40例机械对齐tka。在受限运动对齐组中,分别使用卡尺和软组织引导技术确定股骨和胫骨对齐,ar辅助导航系统提供实时确认角值保持在安全范围内。术中目标延伸间隙为矩形结构,内侧和外侧宽度相等。结果:术中膝关节伸直时软组织不平衡的测量值在受限运动学对齐组明显小于机械对齐组(1.1±1.1°vs 2.5±2.2°;95% CI, 0.7 ~ 2.2°;P结论:采用PCL保留内侧一致假体的受限运动学对齐TKA术中软组织张力比采用后稳定假体的机械对齐TKA更平衡。然而,术后早期行走速度在两组之间没有差异。
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引用次数: 0
The transepicondylar axis or the posterior condylar axis: Which is the best reference for femoral component rotation in robotic-assisted total knee arthroplasty? 经髁突轴或后髁轴:在机器人辅助全膝关节置换术中,哪个是股骨假体旋转的最佳参考?
IF 4.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-02-27 DOI: 10.1186/s42836-025-00362-7
Qing-Da Wei, Hao-Ming An, Yun-Hao Tang, Ming-Feng Li, Rui Li, Wei Chai

Background: For robotic-assisted total knee arthroplasty (TKA), accurate identification of anatomical landmarks directly affects the displayed value for femoral component rotation. This study aimed to quantify the inter-surgeon consistency of the TEA-reference angle (the angle between the transepicondylar axis and the femoral component axis) and the PCA-reference angle (the angle between the posterior condylar axis and the femoral component axis).

Methods: The anatomical data of 56 patients who underwent robotic-assisted TKA at our institution were analyzed. Two surgeons independently identified the transepicondylar axis (TEA) and posterior condylar axis (PCA) landmarks on the 3D femoral models generated by the MAKO TKA system. The TEA-reference angle was recorded as α with the PCA-reference angle standardized to 0°, and the PCA-reference angle was recorded as β with the TEA-reference angle standardized to 0°. The measured values were α1β1 for Surgeon-1 and α2β2 for Surgeon-2. The differences between surgeons for α (∆α = α₁ - α₂) and β (∆β = β₁ - β₂) were calculated. The values of α and β are defined as positive for external rotation and negative for internal rotation.

Results: The inter-surgeon intraclass correlation coefficient (ICC) for α was 0.761 (95% CI: 0.592-0.860), and that for β was 0.943 (95% CI: 0.902-0.966). The absolute difference between surgeons (∆α) was > 2° in 15/56 (26.8%) patients and ≤ 1° in 24/56 (42.9%) patients. With respect to ∆β, 3/56 (5.4%) patients had a difference > 2°, whereas 45/56 (80.4%) patients had a difference ≤ 1°.

Conclusion: The inter-surgeon consistency of the PCA was significantly greater than that of the TEA in robotic-assisted TKA planning. To mitigate the risk of inappropriate femoral component rotation, surgeons should verify landmark positions, particularly in patients with anatomical abnormalities of the distal femur, and consider cross-referencing both axes. Video Abstract.

背景:对于机器人辅助全膝关节置换术(TKA),解剖标志的准确识别直接影响股骨假体旋转的显示值。本研究旨在量化tea参考角(经髁轴与股成分轴之间的角度)和pca参考角(后髁轴与股成分轴之间的角度)在术者间的一致性。方法:对我院56例机器人辅助TKA患者的解剖资料进行分析。两位外科医生在MAKO TKA系统生成的三维股骨模型上独立识别了经髁突轴(TEA)和后髁轴(PCA)标志。将tea -基准角记为α,将pca -基准角标准化为0°;将pca -基准角记为β,将tea -基准角标准化为0°。测量值为α1β1, α2β2。计算外科医生对α(∆α = α₁- α₂)和β(∆β = β₁- β₂)的差异。α和β的值定义为外旋为正,内旋为负。结果:α为0.761 (95% CI: 0.592 ~ 0.860), β为0.943 (95% CI: 0.902 ~ 0.966)。15/56例(26.8%)患者的绝对差异(∆α)为bb0.2°,24/56例(42.9%)患者的绝对差异(∆α)为≤1°。对于∆β, 3/56(5.4%)患者的差异为2°,而45/56(80.4%)患者的差异≤1°。结论:在机器人辅助TKA规划中,PCA的术者间一致性明显大于TEA。为了减轻不适当的股骨假体旋转的风险,外科医生应验证标志性位置,特别是在股骨远端解剖异常的患者中,并考虑交叉参考两个轴。视频摘要。
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引用次数: 0
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Arthroplasty
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