Sourav Chowdhury, S. Das, A. Chakrapani, Aeshrat Banu
A confirmed case of 41-year-old male with T-cell precursor acute lymphoblastic leukemia was inducted to BFM 2002 protocol, induction phase 1 (this protocol includes injection daunorubicin, vincristine, L-asparaginase with triple intrathecal injection of methotrexate, cytosine, hydrocortisone, and oral prednisolone). The patient complained of epigastric pain with hepatosplenomegaly and laboratory investigation revealed deranged lipid profile with hypertriglyceridemia (HTG) as a major feature and hyperbilirubinemia and raised transaminase. He was diagnosed with a case of HTG with acute pancreatitis, a complication, due to L-asparaginase. Initially, his condition was treated with medical management, but reduction in triglyceride (TG) level was not as expected. It was decided then to manage the case with concomitant therapeutic plasma exchange therapy. One exchange not only reduced the TG level drastically but also the bilirubin level and the patient recovered and was able to start the next phase of the protocol.
{"title":"Hypertriglyceridemia with pancreatitis, a complication of l-asparaginase therapy in acute lymphoblastic leukemia, managed by therapeutic plasma exchange","authors":"Sourav Chowdhury, S. Das, A. Chakrapani, Aeshrat Banu","doi":"10.4103/gjtm.gjtm_91_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_91_22","url":null,"abstract":"A confirmed case of 41-year-old male with T-cell precursor acute lymphoblastic leukemia was inducted to BFM 2002 protocol, induction phase 1 (this protocol includes injection daunorubicin, vincristine, L-asparaginase with triple intrathecal injection of methotrexate, cytosine, hydrocortisone, and oral prednisolone). The patient complained of epigastric pain with hepatosplenomegaly and laboratory investigation revealed deranged lipid profile with hypertriglyceridemia (HTG) as a major feature and hyperbilirubinemia and raised transaminase. He was diagnosed with a case of HTG with acute pancreatitis, a complication, due to L-asparaginase. Initially, his condition was treated with medical management, but reduction in triglyceride (TG) level was not as expected. It was decided then to manage the case with concomitant therapeutic plasma exchange therapy. One exchange not only reduced the TG level drastically but also the bilirubin level and the patient recovered and was able to start the next phase of the protocol.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"224 1","pages":"89 - 91"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89172690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Universal leukoreduction-Need of the hour","authors":"Keerthi Chinthapeta","doi":"10.4103/gjtm.gjtm_76_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_76_22","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"30 1","pages":"106 - 106"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88070921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Goldsmith, N. Gebril, D. Thull, Y. Abdella, L. Barski, P. Malgor, F. Bossolini, O. Aldaher, C. S. Smit Sibinga
Background and Objectives: Libya's blood transfusion system suffers from chronic blood shortages due to low rates of voluntary, nonremunerated blood donors (VNRBDs). Over 90% of blood donations are for family members or friends of donors, and only 1% of donors are women. This study aimed to understand the barriers and motivations for blood donation in Libya to support sensitization campaigns. Methods: A knowledge, attitudes, and practices survey was conducted with 896 people in seven Libyan cities where blood banks are located. Key informant interviews were conducted with blood donors, staff, and experts across all seven cities. Thematic content analysis was conducted for the qualitative data, and SPSS was used to produce descriptive statistics. Results: There was a strong awareness of blood donation and the uses of donated blood within the surveyed population. Most respondents who had not donated blood had considered donating. The association between blood donation and Hijama, the traditional medical bloodletting practice, was cited as a sensitization experience for some VNRBDs. The common barriers for potential female donors included misconceptions about female eligibility, social norms, and constraints based on the opinions of their husbands. Conclusion: Sensitization campaigns can encourage people to donate for the first time to dispel fears and reinforce the connection between blood donation and altruistic/religious giving. Religious institutions, including mosques and Hijama centers, must be engaged to emphasize that blood donation is ethically compatible with Islam. Campaigns should also highlight that women are eligible to donate blood.
{"title":"A knowledge, attitudes, and practices survey concerning blood donation among Libyans","authors":"A. Goldsmith, N. Gebril, D. Thull, Y. Abdella, L. Barski, P. Malgor, F. Bossolini, O. Aldaher, C. S. Smit Sibinga","doi":"10.4103/gjtm.gjtm_78_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_78_22","url":null,"abstract":"Background and Objectives: Libya's blood transfusion system suffers from chronic blood shortages due to low rates of voluntary, nonremunerated blood donors (VNRBDs). Over 90% of blood donations are for family members or friends of donors, and only 1% of donors are women. This study aimed to understand the barriers and motivations for blood donation in Libya to support sensitization campaigns. Methods: A knowledge, attitudes, and practices survey was conducted with 896 people in seven Libyan cities where blood banks are located. Key informant interviews were conducted with blood donors, staff, and experts across all seven cities. Thematic content analysis was conducted for the qualitative data, and SPSS was used to produce descriptive statistics. Results: There was a strong awareness of blood donation and the uses of donated blood within the surveyed population. Most respondents who had not donated blood had considered donating. The association between blood donation and Hijama, the traditional medical bloodletting practice, was cited as a sensitization experience for some VNRBDs. The common barriers for potential female donors included misconceptions about female eligibility, social norms, and constraints based on the opinions of their husbands. Conclusion: Sensitization campaigns can encourage people to donate for the first time to dispel fears and reinforce the connection between blood donation and altruistic/religious giving. Religious institutions, including mosques and Hijama centers, must be engaged to emphasize that blood donation is ethically compatible with Islam. Campaigns should also highlight that women are eligible to donate blood.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"25 1","pages":"17 - 22"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81503345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Divya Vijayakumar, P. Shaiji, D. Meena, Soonam John
Background and Objectives: The presence of irregular red cell antibodies in the serum of pregnant women is named maternal alloimmunization. Sensitizing events such as traumatic delivery and miscarriage can cause fetomaternal hemorrhage, increasing the risk of alloimmunization. Our objective was to estimate the prevalence of red cell alloantibodies among multigravidae and to study its association with those cases with bad obstetric history (BOH). Methods: This was a 1-year cross-sectional study done on 900 multigravidae in the Department of Transfusion Medicine, Medical College, Thiruvananthapuram. We excluded patients with a history of blood transfusion. Results: Out of 900 subjects, 49 (5.4%) were alloimmunized. The RhD-positive cases were predominant (77.4%), while 203 (22.6%) were RhD negative. Among the D-positive women, the prevalence of alloimmunization was 1.3%. The most frequent alloantibody identified was anti-D, followed by anti-G (18.4%). The alloantibodies identified among RhD-positive were anti-E, anti-c, anti-C, anti-Fya, anti-M, anti-Jka, and anti-Leb. We identified a total of 58 clinically significant alloantibodies. Thus, Rh blood group alloantibodies constitute 93.1% and the remaining 6.9% by other blood groups. Out of 159 cases with BOH, 17 were alloimmunized, and there was a statistically significant association between them (P = 0.001). Conclusion: Alloantibodies potentially causing hemolytic disease of the fetus and newborn were found in D-negative (19.7%) and D-positive (1.3%) mothers. The clinicians should change the current practice of screening only D-negative pregnant women, and antibody screening should be offered to all females or at least those with BOH. We may thus ensure early detection and periodic monitoring of all alloimmunized women.
{"title":"A prospective study on the prevalence of red cell alloimmunization via fetomaternal hemorrhage and its association with bad obstetric history","authors":"Divya Vijayakumar, P. Shaiji, D. Meena, Soonam John","doi":"10.4103/gjtm.gjtm_75_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_75_22","url":null,"abstract":"Background and Objectives: The presence of irregular red cell antibodies in the serum of pregnant women is named maternal alloimmunization. Sensitizing events such as traumatic delivery and miscarriage can cause fetomaternal hemorrhage, increasing the risk of alloimmunization. Our objective was to estimate the prevalence of red cell alloantibodies among multigravidae and to study its association with those cases with bad obstetric history (BOH). Methods: This was a 1-year cross-sectional study done on 900 multigravidae in the Department of Transfusion Medicine, Medical College, Thiruvananthapuram. We excluded patients with a history of blood transfusion. Results: Out of 900 subjects, 49 (5.4%) were alloimmunized. The RhD-positive cases were predominant (77.4%), while 203 (22.6%) were RhD negative. Among the D-positive women, the prevalence of alloimmunization was 1.3%. The most frequent alloantibody identified was anti-D, followed by anti-G (18.4%). The alloantibodies identified among RhD-positive were anti-E, anti-c, anti-C, anti-Fya, anti-M, anti-Jka, and anti-Leb. We identified a total of 58 clinically significant alloantibodies. Thus, Rh blood group alloantibodies constitute 93.1% and the remaining 6.9% by other blood groups. Out of 159 cases with BOH, 17 were alloimmunized, and there was a statistically significant association between them (P = 0.001). Conclusion: Alloantibodies potentially causing hemolytic disease of the fetus and newborn were found in D-negative (19.7%) and D-positive (1.3%) mothers. The clinicians should change the current practice of screening only D-negative pregnant women, and antibody screening should be offered to all females or at least those with BOH. We may thus ensure early detection and periodic monitoring of all alloimmunized women.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"20 1","pages":"23 - 27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84453001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factor XI inhibitors — a breakthrough in prevention and treatment of thromboembolic disorders","authors":"J. Musial","doi":"10.5603/jtm.2022.0019","DOIUrl":"https://doi.org/10.5603/jtm.2022.0019","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective analysis of selected aspects of public blood transfusion service activities as a starting point for assessment of the status of transfusion medicine in Poland. Part 3: Donations of blood and blood components in the period 1997–2017","authors":"Agata Mikołowska, J. Antoniewicz‐Papis","doi":"10.5603/jtm.2022.0016","DOIUrl":"https://doi.org/10.5603/jtm.2022.0016","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75645201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Undas, J. Windyga, M. Podolak-Dawidziak, A. Klukowska, J. Zdziarska, K. Chojnowski, M. Łętowska, P. Łaguna, J. Treliński, J. Musial, T. Urasiński, A. Mital, W. Mlynarski
{"title":"Congenital/inherited thrombophilia in adults — characteristics, laboratory testing and management. Recommendations of the Hemostasis Group of the Polish Society of Hematology and Transfusiology 2022","authors":"A. Undas, J. Windyga, M. Podolak-Dawidziak, A. Klukowska, J. Zdziarska, K. Chojnowski, M. Łętowska, P. Łaguna, J. Treliński, J. Musial, T. Urasiński, A. Mital, W. Mlynarski","doi":"10.5603/jtm.2022.0014","DOIUrl":"https://doi.org/10.5603/jtm.2022.0014","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86251304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of the frequency of post transfusion adverse reactions and their association with blood components supplied by the Regional Blood Transfusion Center in Poznań (2011–2018)","authors":"Bożena Andrys, K. Korybalska","doi":"10.5603/jtm.2022.0015","DOIUrl":"https://doi.org/10.5603/jtm.2022.0015","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"371 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80464053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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