Pub Date : 2022-08-21DOI: 10.24843/jbn.2022.v06.i02.p05
I. W. Niryana, Kadek Deddy Ariyanta
Latar Belakang: Teratoma sakrokoksigeal (SCTs) adalah neoplasma kongenital yang muncul dari tulang ekor dan terdiri dari jaringan yang berasal dari ketiga lapisan germinal. Diagnosis tidak sulit dalam banyak kasus; namun, harus ada informasi tambahan berupa studi pencitraan untuk mengelola pasien dengan benar. Kasus: Perempuan usia 12 tahun datang dengan keluhan benjolan di bagian atas pantat. Pasien kemudian secara klinis didiagnosis dengan teratoma sakrokoksigeal dengan diagnosis banding lipomielokel. Pasien dilakukan reseksi tumor dan pengangkatan tulang ekor dengan operasi gabungan antara ahli bedah anak dan ahli bedah saraf. Hasil histopatologi menunjukkan gambaran morfologi yang sesuai dengan teratoma sakrokoksigeal. Diagnosis akhir pada pasien ini adalah teratoma sakrokoksigeal Altman 1. Simpulan: Teratoma sakrokoksigeal harus ditangani sedini mungkin untuk menghindari risiko keganasan.
{"title":"Laporan Kasus: Teratoma Menyerupai Lipomielokel","authors":"I. W. Niryana, Kadek Deddy Ariyanta","doi":"10.24843/jbn.2022.v06.i02.p05","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i02.p05","url":null,"abstract":"Latar Belakang: Teratoma sakrokoksigeal (SCTs) adalah neoplasma kongenital yang muncul dari tulang ekor dan terdiri dari jaringan yang berasal dari ketiga lapisan germinal. Diagnosis tidak sulit dalam banyak kasus; namun, harus ada informasi tambahan berupa studi pencitraan untuk mengelola pasien dengan benar. Kasus: Perempuan usia 12 tahun datang dengan keluhan benjolan di bagian atas pantat. Pasien kemudian secara klinis didiagnosis dengan teratoma sakrokoksigeal dengan diagnosis banding lipomielokel. Pasien dilakukan reseksi tumor dan pengangkatan tulang ekor dengan operasi gabungan antara ahli bedah anak dan ahli bedah saraf. Hasil histopatologi menunjukkan gambaran morfologi yang sesuai dengan teratoma sakrokoksigeal. Diagnosis akhir pada pasien ini adalah teratoma sakrokoksigeal Altman 1. Simpulan: Teratoma sakrokoksigeal harus ditangani sedini mungkin untuk menghindari risiko keganasan.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44062976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-11DOI: 10.24843/jbn.2022.v06.i02.p03
A. Wijaya, Nyoman Srie Laksminingsih, I. M. Dwijaputra, G. R. Widiana, G. Duarsa, M. Asih, F. Sitanggang
Aim: Assessed the correlation between prostate volume and intravesical prostatic protrusion with detrusor wall thickness through transabdominal sonographic examination of benign prostate enlargement (BPE). Methods: The study is a paired-group analytical observational cross-sectional study during April – July 2020. Measurements were made of prostate volume, intravesical prostatic protrusion, and detrusor wall thickness using transabdominal sonography. An analysis was carried out to determine the correlation with bivariate analysis and the calculation of the research power. Results: Thirty-four BPE patients with a mean age of 62.41 years were included in the study. The mean value of prostate volume obtained was 44.24 cc; 8.66 mm for intravesical prostatic protrusion; and detrusor wall thickness is 1.49 mm. The correlation value between prostate volume and detrusor wall thickness was 0.12 (p=0.46), while the intravesical prostatic protrusion and detrusor wall thickness were 0.37 (p=0.03). The research power for correlating prostate volume with detrusor wall thickness and intravesical prostatic protrusion with detrusor wall thickness was 10-20% and 50-60%, respectively. Conclusion: There is a very weak correlation between prostate volume and detrusor wall thickness and a weak correlation between the intravesical prostatic protrusion and detrusor wall thickness. Other variables may influence the thickness of the detrusor wall.
{"title":"Correlation of Prostate Volume and Intravesical Prostatic Protrusion with Detrusor Wall Thickness using Transabdominal Ultrasonography in Benign Prostate Enlargement: A Preliminary Study","authors":"A. Wijaya, Nyoman Srie Laksminingsih, I. M. Dwijaputra, G. R. Widiana, G. Duarsa, M. Asih, F. Sitanggang","doi":"10.24843/jbn.2022.v06.i02.p03","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i02.p03","url":null,"abstract":"Aim: Assessed the correlation between prostate volume and intravesical prostatic protrusion with detrusor wall thickness through transabdominal sonographic examination of benign prostate enlargement (BPE). Methods: The study is a paired-group analytical observational cross-sectional study during April – July 2020. Measurements were made of prostate volume, intravesical prostatic protrusion, and detrusor wall thickness using transabdominal sonography. An analysis was carried out to determine the correlation with bivariate analysis and the calculation of the research power. Results: Thirty-four BPE patients with a mean age of 62.41 years were included in the study. The mean value of prostate volume obtained was 44.24 cc; 8.66 mm for intravesical prostatic protrusion; and detrusor wall thickness is 1.49 mm. The correlation value between prostate volume and detrusor wall thickness was 0.12 (p=0.46), while the intravesical prostatic protrusion and detrusor wall thickness were 0.37 (p=0.03). The research power for correlating prostate volume with detrusor wall thickness and intravesical prostatic protrusion with detrusor wall thickness was 10-20% and 50-60%, respectively. Conclusion: There is a very weak correlation between prostate volume and detrusor wall thickness and a weak correlation between the intravesical prostatic protrusion and detrusor wall thickness. Other variables may influence the thickness of the detrusor wall.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68892624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-11DOI: 10.24843/jbn.2022.v06.i02.p04
K. D. Ariyanta, I. Darmajaya, Alexandra Alexandra, Kelvin Setiawan
Background: Long-gap Esophageal Atresia (LGEA) remains one of the most challenging congenital conditions. When primary anastomoses attempts had failed, esophageal replacement (ER) is indicated in these patients. Some infants with LGEA are born with other congenital anomalies, such as rectourethral fistula. In this study, we reported our experience in managing newborn with LGEA and rectourethral fistula. Case: A 1-day-old male neonate complained of unable to swallow any breast milk and presence of feces-like discharge from external urethral orifice within 24 hours after birth. Oral gastric tube was unable to pass into the stomach and x-ray examination revealed curled gastric tube in esophagus, and there wasn’t any bubble seen from patient’s stomach. Patient then was diagnosed with long gap esophageal atresia without fistula. Esophageal replacements using left colon interposition technique was performed as closing and final procedure. Gastrostomy tube insertion, sigmoid colostomy, and cervical esophagostomy were immediately performed. Posterior sagittal anorectoplasty (PSARP) for patient’s recto-urethral fistula were performed six months after sigmoid colostomy. Patient was hospitalized with total of 32 days and gastric feeding tube can be removed three months after surgery. Conclusion: colon interposition can be safely used in long gap esophageal atreasia although patient had undergone previous colostomy repair. Long-term follow up will be needed. Further large-scale studies regarding this matter are necessary and hopefully comprehensive treatment can be established in the future.
{"title":"The The Colon Interposition as Esophageal Replacement in Long-Gap Esophageal Atresia","authors":"K. D. Ariyanta, I. Darmajaya, Alexandra Alexandra, Kelvin Setiawan","doi":"10.24843/jbn.2022.v06.i02.p04","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i02.p04","url":null,"abstract":"Background: Long-gap Esophageal Atresia (LGEA) remains one of the most challenging congenital conditions. When primary anastomoses attempts had failed, esophageal replacement (ER) is indicated in these patients. Some infants with LGEA are born with other congenital anomalies, such as rectourethral fistula. In this study, we reported our experience in managing newborn with LGEA and rectourethral fistula. Case: A 1-day-old male neonate complained of unable to swallow any breast milk and presence of feces-like discharge from external urethral orifice within 24 hours after birth. Oral gastric tube was unable to pass into the stomach and x-ray examination revealed curled gastric tube in esophagus, and there wasn’t any bubble seen from patient’s stomach. Patient then was diagnosed with long gap esophageal atresia without fistula. Esophageal replacements using left colon interposition technique was performed as closing and final procedure. Gastrostomy tube insertion, sigmoid colostomy, and cervical esophagostomy were immediately performed. Posterior sagittal anorectoplasty (PSARP) for patient’s recto-urethral fistula were performed six months after sigmoid colostomy. Patient was hospitalized with total of 32 days and gastric feeding tube can be removed three months after surgery. Conclusion: colon interposition can be safely used in long gap esophageal atreasia although patient had undergone previous colostomy repair. Long-term follow up will be needed. Further large-scale studies regarding this matter are necessary and hopefully comprehensive treatment can be established in the future. \u0000 ","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45275560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.24843/jbn.2022.v06.i02.p02
Paulus Lukman, Mendy Hatibie Oley, Djarot Noersasongko, F. Langi
Tujuan: Untuk mengetahui hubungan terapi oksigen hiperbarik (TOHB) dan interleukin (IL) -6 terhadap penyembuhan luka setelah dilakukan operasi pada fraktur tibia. Metode: Penelitian ini merupakan randomized controlled trial yang membandingkan pasien dengan TOHB dan kontrol (tanpa TOHB). Semua pasien menjalani operasi reduksi terbuka dan fiksasi internal. Pasien dengan TOHB akan mendapatkan terapi oksigen hiperbarik. Luka operasi dan kadar IL-6 dievaluasi dua minggu pasca operasi untuk melihat ada tidaknya dehisensi. Hasil: Penelitian ini menemukan bahwa kadar faktor inflamasi jauh lebih rendah pada kelompok TOHB dibanding kontrol (31,1 vs 38,4 pg/mL; p = 0,003). Kadar IL-6 secara keseluruhan turun menjadi 20 pg/mL setelah terapi, dimana kelompok TOHB memiliki kadar IL-6 yang jauh lebih rendah dibandingkan kontrol (median 16,4 vs 35,4 pg/mL; p < 0,001). Pemberian oksigen hiperbarik berperan terhadap rerata penurunan IL-6 sebesar 11,07 pg/mL (IK 95% 7,80- 14,34 pg/mL; p <0,001) lebih tinggi pada mereka yang menerima terapi tersebut dibandingkan kontrol. Simpulan: TOHB dapat mencegah terjadinya dehisensi luka dengan mengurangi edema yang ditandai dengan penurunan kadar IL-6.
{"title":"Pengaruh Terapi Oksigen Hiperbarik Untuk Mencegah Dehisensi Luka Pada Fraktur Shaft Tibia Pasca Operasi dan Hubungannya Dengan IL-6","authors":"Paulus Lukman, Mendy Hatibie Oley, Djarot Noersasongko, F. Langi","doi":"10.24843/jbn.2022.v06.i02.p02","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i02.p02","url":null,"abstract":"Tujuan: Untuk mengetahui hubungan terapi oksigen hiperbarik (TOHB) dan interleukin (IL) -6 terhadap penyembuhan luka setelah dilakukan operasi pada fraktur tibia. Metode: Penelitian ini merupakan randomized controlled trial yang membandingkan pasien dengan TOHB dan kontrol (tanpa TOHB). Semua pasien menjalani operasi reduksi terbuka dan fiksasi internal. Pasien dengan TOHB akan mendapatkan terapi oksigen hiperbarik. Luka operasi dan kadar IL-6 dievaluasi dua minggu pasca operasi untuk melihat ada tidaknya dehisensi. Hasil: Penelitian ini menemukan bahwa kadar faktor inflamasi jauh lebih rendah pada kelompok TOHB dibanding kontrol (31,1 vs 38,4 pg/mL; p = 0,003). Kadar IL-6 secara keseluruhan turun menjadi 20 pg/mL setelah terapi, dimana kelompok TOHB memiliki kadar IL-6 yang jauh lebih rendah dibandingkan kontrol (median 16,4 vs 35,4 pg/mL; p < 0,001). Pemberian oksigen hiperbarik berperan terhadap rerata penurunan IL-6 sebesar 11,07 pg/mL (IK 95% 7,80- 14,34 pg/mL; p <0,001) lebih tinggi pada mereka yang menerima terapi tersebut dibandingkan kontrol. Simpulan: TOHB dapat mencegah terjadinya dehisensi luka dengan mengurangi edema yang ditandai dengan penurunan kadar IL-6.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46516345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-10DOI: 10.24843/jbn.2022.v06.i02.p01
Mutiara Tri Florettira, Efman Efraim Ulrich Manawan, Subandrate Subandrate
Aim: To determine the lipid profile of cholelithiasis patients at Dr. Mohammad Hoesin Central General Hospital, Palembang. Methods: This study was an observational descriptive study. The data were obtained from medical records in the Medical Record Centre of Dr. Mohammad Hoesin Hospital during the period of 1 January 2016 – 30 June 2019 by total sampling technique. Collecting data from medical record were patient’s age, gender, body mass index (BMI), occupation and lipid profile. Results: Most cholelithiasis patients were > 40 years old (69.6% of 253 patients), female (62.1% of 253 patients), normal BMI (42.6% of 195 patients), and a housewife (38% of 163 patients). The mean of total cholesterol level in 38 patients was 191.82 ± 49.63 mg/dL (104 – 350 mg/dL), the mean triglyceride level in 32 patients was117.16 ± 43.46 mg/dL (36 – 212 mg/dL), the mean of LDL level in 35 patients was 125.31 ± 36.64 mg/dL (62 – 244 mg/dL) and the mean HDL level in 36 patients was 43.33 ± 14.35 mg/dL (17 – 84 mg/dL). Conclusion: Almost all cholelithiasis patients at Dr. Mohammad Hoesin Central General Hospital, Palembang had normal lipid profile.
{"title":"Lipid Profile of Cholelithiasis Patients at Dr. Mohammad Hoesin Central General Hospital, Palembang","authors":"Mutiara Tri Florettira, Efman Efraim Ulrich Manawan, Subandrate Subandrate","doi":"10.24843/jbn.2022.v06.i02.p01","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i02.p01","url":null,"abstract":"Aim: To determine the lipid profile of cholelithiasis patients at Dr. Mohammad Hoesin Central General Hospital, Palembang. Methods: This study was an observational descriptive study. The data were obtained from medical records in the Medical Record Centre of Dr. Mohammad Hoesin Hospital during the period of 1 January 2016 – 30 June 2019 by total sampling technique. Collecting data from medical record were patient’s age, gender, body mass index (BMI), occupation and lipid profile. Results: Most cholelithiasis patients were > 40 years old (69.6% of 253 patients), female (62.1% of 253 patients), normal BMI (42.6% of 195 patients), and a housewife (38% of 163 patients). The mean of total cholesterol level in 38 patients was 191.82 ± 49.63 mg/dL (104 – 350 mg/dL), the mean triglyceride level in 32 patients was117.16 ± 43.46 mg/dL (36 – 212 mg/dL), the mean of LDL level in 35 patients was 125.31 ± 36.64 mg/dL (62 – 244 mg/dL) and the mean HDL level in 36 patients was 43.33 ± 14.35 mg/dL (17 – 84 mg/dL). Conclusion: Almost all cholelithiasis patients at Dr. Mohammad Hoesin Central General Hospital, Palembang had normal lipid profile.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68893087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.24843/jbn.2022.v06.i01.p02
I. Kartika, M. Asih, Elysanti Dwi Martadiani, Pande Anandasari, Putu Patriawan, I. Widiana
Background: Increasing number of cancer survivor motivates clinical practitioner to focus on chronic effect of chemotherapy agent, especially those with vascular toxicity effect, which may attenuate the incidence of thrombosis and atherogenesis. Ultrasonography examination on carotid intima media thickness (C-IMT) provides acurate result in evaluating atherosclerotic. The purposes of this research are to find out any structural changes of carotid artery, especially atheroclerosis changes in breast cancer patient after chemoteraphy. Methods: Analytic cross sectional study using a pre post test group design in breast cancer patients. Eligible subjects undergo carotid ultrasonography examination prior to chemoteraphy and after they had completed the 3 cycles of chemoteraphy for the second exam. The examination was perfomed with the same USG machine, high frequency linier transducer (>7mHz) in B-mode under the auspecies of two reputable radiologist consultant. Results: Total patients are 26, mean of age (year) is 47.15 ± 8.11. Most dominant histopathology finding is invasive carcinoma nonspecific type, in 24 patients (92.4%) and the disease stage is in stadium III in 14 patients (53.9%). Mean C-IMT (mm) prior chemotherapy is 0.51 ± 0.06 and after chemotherapy is 0.58 ± 0.05, there is an increase of 0.07 ± 0.06 (p<0.0001). Carotid artery lumen diameter (mm) before chemotherapy is 4.05 ± 0.66 and after chemotherapy is 3.90 ± 0.73, so there is a decrease of 0.16 ± 0.40 (p =0.057). Conclusion: There is a statistically significant increase in intima media thickness of carotid wall of breast cancer patients after chemotherapy, consisted with chemoteraphy induced atherosclerosis.
{"title":"Increase of Carotid Intima-Media Thickness and Reduction of Carotid Artery Lumen Diameter in Breast Cancer Patient Before and After Chemotherapy","authors":"I. Kartika, M. Asih, Elysanti Dwi Martadiani, Pande Anandasari, Putu Patriawan, I. Widiana","doi":"10.24843/jbn.2022.v06.i01.p02","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i01.p02","url":null,"abstract":"Background: Increasing number of cancer survivor motivates clinical practitioner to focus on chronic effect of chemotherapy agent, especially those with vascular toxicity effect, which may attenuate the incidence of thrombosis and atherogenesis. Ultrasonography examination on carotid intima media thickness (C-IMT) provides acurate result in evaluating atherosclerotic. The purposes of this research are to find out any structural changes of carotid artery, especially atheroclerosis changes in breast cancer patient after chemoteraphy. Methods: Analytic cross sectional study using a pre post test group design in breast cancer patients. Eligible subjects undergo carotid ultrasonography examination prior to chemoteraphy and after they had completed the 3 cycles of chemoteraphy for the second exam. The examination was perfomed with the same USG machine, high frequency linier transducer (>7mHz) in B-mode under the auspecies of two reputable radiologist consultant. Results: Total patients are 26, mean of age (year) is 47.15 ± 8.11. Most dominant histopathology finding is invasive carcinoma nonspecific type, in 24 patients (92.4%) and the disease stage is in stadium III in 14 patients (53.9%). Mean C-IMT (mm) prior chemotherapy is 0.51 ± 0.06 and after chemotherapy is 0.58 ± 0.05, there is an increase of 0.07 ± 0.06 (p<0.0001). Carotid artery lumen diameter (mm) before chemotherapy is 4.05 ± 0.66 and after chemotherapy is 3.90 ± 0.73, so there is a decrease of 0.16 ± 0.40 (p =0.057). Conclusion: There is a statistically significant increase in intima media thickness of carotid wall of breast cancer patients after chemotherapy, consisted with chemoteraphy induced atherosclerosis.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44339477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.24843/jbn.2022.v06.i01.p05
I. Suarsana, Andi Asadul Islam, P. Prihantono, Berti Nelwan
Kanker payudara merupakan penyebab kematian akibat kanker terbanyak pada wanita di seluruh dunia dengan angka kematian sebesar 458.400 wanita setiap tahunnya. Poly-(ADP ribose) polymerase (PARP) dan phosphatidylinositol 3-kinase (PI3K) adalah dua molekul yang memainkan peran penting pada patofisiologi kanker payudara. Metastasis kanker payudara merupakan sebuah proses berkesinambungan yang melibatkan beberapa tahapan penting seperti invasi, angiogenesis, hingga replikasi sel. Sel yang mengalami mutasi pada kanker payudara akan menyebabkan ekspresi yang berlebihan dari PI3K sehingga terjadi replikasi sel yang tidak terkontrol disertai dengan peningkatan matrix metallopeptidase 9 (MMP-9). MMP-9 memiliki peran dalam degradasi matriks ekstraseluler yang penting untuk proses invasi tumor. Di sisi lain, PARP membantu reparasi sel yang mengalami kerusakan sehingga proses replikasi sel kanker dapat terus berlangsung. Terlebih lagi, PARP diketahui memiliki andil besar dalam proses angiogenesis sel kanker. Gabungan dari kedua fenomena tersebut menghasilkan sel kanker dengan kemampuan replikasi dan metastasis yang tinggi.
{"title":"Peran Poly-(ADP ribose) polymerase (PARP) dan Phosphatidylinositol 3-kinase (PI3K) Terhadap Terjadinya Kejadian Metastasis pada Kanker Payudara","authors":"I. Suarsana, Andi Asadul Islam, P. Prihantono, Berti Nelwan","doi":"10.24843/jbn.2022.v06.i01.p05","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i01.p05","url":null,"abstract":"Kanker payudara merupakan penyebab kematian akibat kanker terbanyak pada wanita di seluruh dunia dengan angka kematian sebesar 458.400 wanita setiap tahunnya. Poly-(ADP ribose) polymerase (PARP) dan phosphatidylinositol 3-kinase (PI3K) adalah dua molekul yang memainkan peran penting pada patofisiologi kanker payudara. Metastasis kanker payudara merupakan sebuah proses berkesinambungan yang melibatkan beberapa tahapan penting seperti invasi, angiogenesis, hingga replikasi sel. Sel yang mengalami mutasi pada kanker payudara akan menyebabkan ekspresi yang berlebihan dari PI3K sehingga terjadi replikasi sel yang tidak terkontrol disertai dengan peningkatan matrix metallopeptidase 9 (MMP-9). MMP-9 memiliki peran dalam degradasi matriks ekstraseluler yang penting untuk proses invasi tumor. Di sisi lain, PARP membantu reparasi sel yang mengalami kerusakan sehingga proses replikasi sel kanker dapat terus berlangsung. Terlebih lagi, PARP diketahui memiliki andil besar dalam proses angiogenesis sel kanker. Gabungan dari kedua fenomena tersebut menghasilkan sel kanker dengan kemampuan replikasi dan metastasis yang tinggi. ","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42933142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.24843/jbn.2022.v06.i01.p04
I. G. Wibawa, Komang Trisna Sumadewi, Putu Nita Cahyawati
Latar belakang: Gagal ginjal kronik (GGK) merupakan salah satu penyakit dengan tingkat mortalitas yang tinggi. Pada pasien GGK, golongan obat statin digunakan untuk mengatasi kondisi dislipidemia dan mencegah kelainan kardiovaskular. Selama ini banyak penelitian lebih terfokus meneliti efek pemberian statin terhadap kondisi ginjal dibandingkan dengan kondisi hepar. Penelitian ini bertujuan untuk mengetahui efek simvastatin terhadap perubahan pada degenerasi hidropis dan nekrosis sel hepatosit mencit model subtotal nefrektomi. Metode: Lima belas ekor mencit (Mus musculus L.) jantan, galur Swiss, umur 3 bulan, berat badan 30-40 gram digunakan pada penelitian ini. Mencit dibagi menjadi 3 kelompok perlakuan secara random yaitu kelompok subtotal nefrektomi (SN, n=5), kelompok simvastatin dosis 5,2 mg/kgBB (S5, n=5), dan kelompok simvastatin dosis 10,4 mg/kgBB (S10, n=5). Hasil: Hasil pemeriksaan histopatologi menunjukkan bahwa rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbedaan signifikan pada penilaian degenersi hidropis pada kelompok SN dan kelompok S5 (p<0,05). Rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbeda an signifikan antara kelompok hewan yang memperoleh simvastatin (S5 dan S10) dengan kelompok SN (p<0,05). Simpulan: Simvastatin memperbaiki degerasi hidropis dan nekrosis sel hepatosit mencit subtotal nefrektomi.
{"title":"Simvastatin Memperbaiki Degerasi Hidropis dan Nekrosis Sel Hepatosit Mencit Subtotal Nefrektomi","authors":"I. G. Wibawa, Komang Trisna Sumadewi, Putu Nita Cahyawati","doi":"10.24843/jbn.2022.v06.i01.p04","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i01.p04","url":null,"abstract":"Latar belakang: Gagal ginjal kronik (GGK) merupakan salah satu penyakit dengan tingkat mortalitas yang tinggi. Pada pasien GGK, golongan obat statin digunakan untuk mengatasi kondisi dislipidemia dan mencegah kelainan kardiovaskular. Selama ini banyak penelitian lebih terfokus meneliti efek pemberian statin terhadap kondisi ginjal dibandingkan dengan kondisi hepar. Penelitian ini bertujuan untuk mengetahui efek simvastatin terhadap perubahan pada degenerasi hidropis dan nekrosis sel hepatosit mencit model subtotal nefrektomi. Metode: Lima belas ekor mencit (Mus musculus L.) jantan, galur Swiss, umur 3 bulan, berat badan 30-40 gram digunakan pada penelitian ini. Mencit dibagi menjadi 3 kelompok perlakuan secara random yaitu kelompok subtotal nefrektomi (SN, n=5), kelompok simvastatin dosis 5,2 mg/kgBB (S5, n=5), dan kelompok simvastatin dosis 10,4 mg/kgBB (S10, n=5). Hasil: Hasil pemeriksaan histopatologi menunjukkan bahwa rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbedaan signifikan pada penilaian degenersi hidropis pada kelompok SN dan kelompok S5 (p<0,05). Rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbeda an signifikan antara kelompok hewan yang memperoleh simvastatin (S5 dan S10) dengan kelompok SN (p<0,05). Simpulan: Simvastatin memperbaiki degerasi hidropis dan nekrosis sel hepatosit mencit subtotal nefrektomi.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44388115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.24843/jbn.2022.v06.i01.p03
Ni Luh Putu Julita Yanti, I. Niryana, S. Maliawan, I. N. Semadi, T. Mahadewa, I. G. A. B. K. Wibawa
Background: Craniotomy and decompressive craniectomy and are surgical modalities for the evacuation of acute subdural hematoma (SDH). These two techniques show different outcomes in various existing studies. The superiority between either techniques remains controversial. Objective: To determine the outcome comparison of mortality and Glasgow Outcome Scale Extended (GOSE) craniotomy with decompressive craniectomy in patients with traumatic acute SDH. Methods: This is a historical cohort study. Samples of the study were collected from January 2018 to March 2020 at Sanglah General Hospital. All patients with acute traumatic SDH who underwent SDH evacuation with craniotomy and decompressive craniectomy were assessed for mortality status at discharge and GOSE 3 months after surgery. Independent T-test will be carried out if the numerical variable were all normally distributed, while Mann-Whitney U test will be performed if otherwise. A Chi-square test will be performed on all unpaired categorical variables. Statistical analysis was performed with SPSS 25 with 95% confidence intervals. Results: As many as 40 subjects with traumatic acute SDH who underwent craniotomy and 40 subjects with traumatic acute SDH who underwent decompressive craniectomy were included in this study. There was no significant difference in mortality (RR: 1; 95% CI 0.67-1.87; p=0.651) and GOSE score (p=0.718) in traumatic acute SDH who underwent craniotomy or decompressive craniectomy. Conclusion: There was no difference in mortality and GOSE outcomes between a craniotomy and decompressive craniectomy for management of traumatic acute SDH.
背景:开颅术和减压术是治疗急性硬膜下血肿(SDH)的手术方式。这两种技术在各种现有研究中显示出不同的结果。这两种技术之间的优势仍然存在争议。目的:比较外伤性急性SDH患者的死亡率和格拉斯哥预后评分扩展(GOSE)开颅与减压开颅的结果。方法:这是一项历史队列研究。该研究的样本于2018年1月至2020年3月在Sanglah总医院收集。所有急性外伤性SDH患者均行SDH清除术并开颅减压，术后3个月评估出院时的死亡率和GOSE。若数值变量均为正态分布，则采用独立t检验，否则采用Mann-Whitney U检验。对所有未配对的分类变量进行卡方检验。统计学分析采用SPSS 25，置信区间为95%。结果:本研究共纳入40例外伤性急性SDH患者行开颅手术和40例外伤性急性SDH患者行减压开颅手术。两组死亡率无显著差异(RR: 1;95% ci 0.67-1.87;p=0.651)和GOSE评分(p=0.718)。结论:外伤性急性SDH的死亡率和GOSE结果在开颅手术和减压开颅手术之间没有差异。
{"title":"Comparison of Mortality and Glasgow Outcome Scale Extended (GOSE) between Craniotomy and Decompressive Craniectomy in Patients with Traumatic Acute Subdural Hematoma at Sanglah General Hospital, Bali","authors":"Ni Luh Putu Julita Yanti, I. Niryana, S. Maliawan, I. N. Semadi, T. Mahadewa, I. G. A. B. K. Wibawa","doi":"10.24843/jbn.2022.v06.i01.p03","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i01.p03","url":null,"abstract":"Background: Craniotomy and decompressive craniectomy and are surgical modalities for the evacuation of acute subdural hematoma (SDH). These two techniques show different outcomes in various existing studies. The superiority between either techniques remains controversial. Objective: To determine the outcome comparison of mortality and Glasgow Outcome Scale Extended (GOSE) craniotomy with decompressive craniectomy in patients with traumatic acute SDH. Methods: This is a historical cohort study. Samples of the study were collected from January 2018 to March 2020 at Sanglah General Hospital. All patients with acute traumatic SDH who underwent SDH evacuation with craniotomy and decompressive craniectomy were assessed for mortality status at discharge and GOSE 3 months after surgery. Independent T-test will be carried out if the numerical variable were all normally distributed, while Mann-Whitney U test will be performed if otherwise. A Chi-square test will be performed on all unpaired categorical variables. Statistical analysis was performed with SPSS 25 with 95% confidence intervals. Results: As many as 40 subjects with traumatic acute SDH who underwent craniotomy and 40 subjects with traumatic acute SDH who underwent decompressive craniectomy were included in this study. There was no significant difference in mortality (RR: 1; 95% CI 0.67-1.87; p=0.651) and GOSE score (p=0.718) in traumatic acute SDH who underwent craniotomy or decompressive craniectomy. Conclusion: There was no difference in mortality and GOSE outcomes between a craniotomy and decompressive craniectomy for management of traumatic acute SDH.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45903219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-16DOI: 10.24843/jbn.2022.v06.i01.p01
G. N. K. Dinatha, Anak Agung Gde Oka, K. Santosa
Objective: To determine the predictive factors that influence the outcome of Double “J” (DJ) stent placement in stage IIIB cervical cancer patients with hydronephrosis complications. Methods: An analytical observational study with a historical cohort was performed. Patients included in this study was patient with stage IIIB cervical cancer with hydronephrosis complication at Sanglah hospital. We analyzed the influence of time range since diagnosis until DJ stent placement, degree of hydronephrosis, and glomerular filtration rate on the outcomes of DJ stent placement namely: Lower urinary tract symptoms (LUTS), quality of life (QoL), and glomerular filtration rate changes (GFR). Data were tabulated and statistically analyzed using SPSS 25. Results: Of the 44 samples, the mean age of the patients was 51,93 (±7.672) years. Late DJ stent placement increase the risk of severe LUTS (RR: 3.103; 95%CI: 1.319-7.301; p<0.001) compared to patients with early DJ stent placement. We also found that a low glomerular filtration rate (bad renal function) is significantly associated with worse quality of life (RR: 1.917; 95%CI: 1.296-2.835; p<0.001). Conclusion: Delayed DJ stent placement is associated with severe LUTS symptoms, and poor renal function resulted in a poor quality of life.
{"title":"Predictive Factors Influencing the Outcomes of Double “J” Stent Placement in Stage IIIB Cervical Cancer Patients With Hydronephrosis Complication","authors":"G. N. K. Dinatha, Anak Agung Gde Oka, K. Santosa","doi":"10.24843/jbn.2022.v06.i01.p01","DOIUrl":"https://doi.org/10.24843/jbn.2022.v06.i01.p01","url":null,"abstract":"Objective: To determine the predictive factors that influence the outcome of Double “J” (DJ) stent placement in stage IIIB cervical cancer patients with hydronephrosis complications. Methods: An analytical observational study with a historical cohort was performed. Patients included in this study was patient with stage IIIB cervical cancer with hydronephrosis complication at Sanglah hospital. We analyzed the influence of time range since diagnosis until DJ stent placement, degree of hydronephrosis, and glomerular filtration rate on the outcomes of DJ stent placement namely: Lower urinary tract symptoms (LUTS), quality of life (QoL), and glomerular filtration rate changes (GFR). Data were tabulated and statistically analyzed using SPSS 25. Results: Of the 44 samples, the mean age of the patients was 51,93 (±7.672) years. Late DJ stent placement increase the risk of severe LUTS (RR: 3.103; 95%CI: 1.319-7.301; p<0.001) compared to patients with early DJ stent placement. We also found that a low glomerular filtration rate (bad renal function) is significantly associated with worse quality of life (RR: 1.917; 95%CI: 1.296-2.835; p<0.001). Conclusion: Delayed DJ stent placement is associated with severe LUTS symptoms, and poor renal function resulted in a poor quality of life.","PeriodicalId":52988,"journal":{"name":"JBN Jurnal Bedah Nasional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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