Pub Date : 2021-03-24DOI: 10.1007/s13237-021-00349-0
K. C. Saini, F. Bast, Sanjeeva Nayaka, A. Gautam
{"title":"Morpho-molecular characterization of rock-inhabiting lichen Dermatocarpon miniatum (Verrucariaceae, Ascomycota) and its symbiont in Indian Himalayas","authors":"K. C. Saini, F. Bast, Sanjeeva Nayaka, A. Gautam","doi":"10.1007/s13237-021-00349-0","DOIUrl":"https://doi.org/10.1007/s13237-021-00349-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"193 - 202"},"PeriodicalIF":1.8,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-021-00349-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48385334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-16DOI: 10.1007/s13237-021-00348-1
Y. Vimala, U. C. Lavania
{"title":"Genomic territories in inter-genomic hybrids: the winners and losers with hybrid fixation","authors":"Y. Vimala, U. C. Lavania","doi":"10.1007/s13237-021-00348-1","DOIUrl":"https://doi.org/10.1007/s13237-021-00348-1","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"1 - 6"},"PeriodicalIF":1.8,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-021-00348-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41718173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-19DOI: 10.1007/s13237-020-00346-9
Archismaan Ghosh, S. Mukherjee, M. Roy, A. Datta
{"title":"Modulatory role of tea in arsenic induced epigenetic alterations in carcinogenesis","authors":"Archismaan Ghosh, S. Mukherjee, M. Roy, A. Datta","doi":"10.1007/s13237-020-00346-9","DOIUrl":"https://doi.org/10.1007/s13237-020-00346-9","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"143 - 156"},"PeriodicalIF":1.8,"publicationDate":"2021-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00346-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43797718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-03DOI: 10.1007/s13237-020-00347-8
V. Kumari, Jaswant Singh, V. Singhal
{"title":"A report of intraspecific polyploidy (4x, 6x) in Festuca gigantea (L.) Vill (Family: Poaceae) from Western Himalaya, India and comments on its cyto-geography","authors":"V. Kumari, Jaswant Singh, V. Singhal","doi":"10.1007/s13237-020-00347-8","DOIUrl":"https://doi.org/10.1007/s13237-020-00347-8","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"219 - 223"},"PeriodicalIF":1.8,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00347-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47120229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-07-02DOI: 10.1007/s13237-021-00361-4
Anirban Bhar
Any disease that spreads quickly and crossed the geographical barrier is termed as pandemic. After the initial occurrence of Covid-19 from China, World Health Organization had declared novel corona viral outbreak as pandemic on March, 2020. Since then, COVID-19 continued to devastate people all around the world. Human civilization has witnessed one of its greatest crises by facing 180 million of confirmed cases with 38.9 lakh deaths across the world till end of June 2021. India alone contributes 30 million of positive cases and has lost 3.92 lakh valuable lives (data as on 24th of June 2021 from CSSEGIS and Data (http://github.com/CSSEGISandData/COVID-19); (the number increases in each day). Bio-medical experts from all around the world are working tirelessly to limit the disease and find potential cures for this viral infection. Vaccination is the most effective strategy to prevent the spread of any viral disease. Virologists have developed some effective vaccines, but production or supply lags far behind the present demand across the globe. Plant-derived vaccines (PDVs) based on modified virus like particles (VLPs) can be a feasible alternative in this case. A summarized account about the efficacy of the first plant-derived Covid 19 vaccine, CoVLP is discussed. PDVs and VLPs are also reviewed briefly, along with their benefits and drawbacks.
{"title":"Is it possible to ensure COVID19 vaccine supply by using plants?","authors":"Anirban Bhar","doi":"10.1007/s13237-021-00361-4","DOIUrl":"https://doi.org/10.1007/s13237-021-00361-4","url":null,"abstract":"<p><p>Any disease that spreads quickly and crossed the geographical barrier is termed as pandemic. After the initial occurrence of Covid-19 from China, World Health Organization had declared novel corona viral outbreak as pandemic on March, 2020. Since then, COVID-19 continued to devastate people all around the world. Human civilization has witnessed one of its greatest crises by facing 180 million of confirmed cases with 38.9 lakh deaths across the world till end of June 2021. India alone contributes 30 million of positive cases and has lost 3.92 lakh valuable lives (data as on 24<sup>th</sup> of June 2021 from CSSEGIS and Data (http://github.com/CSSEGISandData/COVID-19); (the number increases in each day). Bio-medical experts from all around the world are working tirelessly to limit the disease and find potential cures for this viral infection. Vaccination is the most effective strategy to prevent the spread of any viral disease. Virologists have developed some effective vaccines, but production or supply lags far behind the present demand across the globe. Plant-derived vaccines (PDVs) based on modified virus like particles (VLPs) can be a feasible alternative in this case. A summarized account about the efficacy of the first plant-derived Covid 19 vaccine, CoVLP is discussed. PDVs and VLPs are also reviewed briefly, along with their benefits and drawbacks.</p>","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 2","pages":"137-141"},"PeriodicalIF":1.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-021-00361-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39173318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-10-16DOI: 10.1007/s13237-021-00378-9
Sounak Ghosh Roy
Autophagy is a homeostatic process designed to eliminate dysfunctional and aging organelles and misfolded proteins through a well-concerted pathway, starting with forming a double-membrane vesicle and culminating in the lysosomal degradation of the cargo enclosed inside the mature vesicle. As a vital sentry of cellular health, autophagy is regulated in every human disease condition and is an essential target for non-coding RNAs like microRNAs (miRNAs). miRNAs are short oligonucleotides that specifically bind to the 3'-untranslated region (UTR) of target mRNAs, thus leading to mRNA silencing, degradation, or translation blockage. This review summarizes the recent findings regarding the regulation of autophagy and autophagy-related genes by different miRNAs in various pathological conditions, including cancer, kidney and liver disorders, neurodegeneration, cardiovascular disorders, infectious diseases, aging-related conditions, and inflammation-related diseases. As miRNAs are being identified as prime regulators of autophagy in human disease, pharmacological molecules and traditional medicines targeting these miRNAs are also being tested in disease models, thus initiating a new series of therapeutic interventions targeting autophagy.
{"title":"Regulation of autophagy by miRNAs in human diseases.","authors":"Sounak Ghosh Roy","doi":"10.1007/s13237-021-00378-9","DOIUrl":"https://doi.org/10.1007/s13237-021-00378-9","url":null,"abstract":"<p><p>Autophagy is a homeostatic process designed to eliminate dysfunctional and aging organelles and misfolded proteins through a well-concerted pathway, starting with forming a double-membrane vesicle and culminating in the lysosomal degradation of the cargo enclosed inside the mature vesicle. As a vital sentry of cellular health, autophagy is regulated in every human disease condition and is an essential target for non-coding RNAs like microRNAs (miRNAs). miRNAs are short oligonucleotides that specifically bind to the 3'-untranslated region (UTR) of target mRNAs, thus leading to mRNA silencing, degradation, or translation blockage. This review summarizes the recent findings regarding the regulation of autophagy and autophagy-related genes by different miRNAs in various pathological conditions, including cancer, kidney and liver disorders, neurodegeneration, cardiovascular disorders, infectious diseases, aging-related conditions, and inflammation-related diseases. As miRNAs are being identified as prime regulators of autophagy in human disease, pharmacological molecules and traditional medicines targeting these miRNAs are also being tested in disease models, thus initiating a new series of therapeutic interventions targeting autophagy.</p>","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":" ","pages":"317-329"},"PeriodicalIF":1.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39551657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/s13237-020-00345-w
Neha Singh, P. Soni, B. Kushwaha, M. S. Kumar, J. K. Srivastava, S. Srivastava, Akhilesh Kumar Mishra, Ravindra Kumar
{"title":"Establishment of a testis cell line from Clarias magur: a potential resource for in-vitro applications","authors":"Neha Singh, P. Soni, B. Kushwaha, M. S. Kumar, J. K. Srivastava, S. Srivastava, Akhilesh Kumar Mishra, Ravindra Kumar","doi":"10.1007/s13237-020-00345-w","DOIUrl":"https://doi.org/10.1007/s13237-020-00345-w","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"211 - 217"},"PeriodicalIF":1.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00345-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52776098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-21DOI: 10.1007/s13237-020-00344-x
Ravindra Kumar, V. Baisvar, B. Kushwaha, M. Pandey, Mahender Singh
{"title":"Individual chromosome identification in Clarias magur using BAC-FISH and comparative genes analyses","authors":"Ravindra Kumar, V. Baisvar, B. Kushwaha, M. Pandey, Mahender Singh","doi":"10.1007/s13237-020-00344-x","DOIUrl":"https://doi.org/10.1007/s13237-020-00344-x","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"64 1","pages":"203 - 209"},"PeriodicalIF":1.8,"publicationDate":"2020-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00344-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41942043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-19DOI: 10.1007/s13237-020-00342-z
M. Prasad
{"title":"Omics of neglected and underutilized crop species: one small step for NUCS, one giant leap for addressing global hunger","authors":"M. Prasad","doi":"10.1007/s13237-020-00342-z","DOIUrl":"https://doi.org/10.1007/s13237-020-00342-z","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"63 1","pages":"213 - 215"},"PeriodicalIF":1.8,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00342-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41325863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-27DOI: 10.1007/s13237-020-00341-0
Nisha Singh, Vandna Rai, N. Singh
{"title":"Multi-omics strategies and prospects to enhance seed quality and nutritional traits in pigeonpea","authors":"Nisha Singh, Vandna Rai, N. Singh","doi":"10.1007/s13237-020-00341-0","DOIUrl":"https://doi.org/10.1007/s13237-020-00341-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"63 1","pages":"249 - 256"},"PeriodicalIF":1.8,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13237-020-00341-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47695469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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