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Glanzmann Thrombasthenia – A Rare Case Report 格兰兹曼血栓形成症--罕见病例报告
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74874
Sabrina Rahman, Maha Harun, T. Dipta, Farida Parvin
Glanzmann thrombasthenia is a rare inherited bleeding disorder resulting from mutation in platelet membrane glycoprotein (GP) IIb or IIIa leading to impaired platelet function which is characterized by defective platelet aggregation and diminished clot retraction. Glanzmann thrombasthenia patients commonly visit to physician with features of bleeding. Here we discuss about the case of a 32-years-old young female presented with menorrhagia, ecchymosis and occasional gum bleeding. Her coagulation profile was in favor of Glanzmann thrombasthenia. This rare disease has a good outcome if early diagnosis and proper management can be ensured.   Delta Med Col J. Jan 2021;9(2): 101-103 
格兰兹曼血栓形成症是一种罕见的遗传性出血性疾病,是由于血小板膜糖蛋白(GP)IIb或IIIa发生突变,导致血小板功能受损,其特点是血小板聚集功能缺陷和血块回缩功能减弱。格兰兹曼血栓形成症患者通常以出血为特征就诊。本文讨论的病例是一名 32 岁的年轻女性,表现为月经过多、瘀斑和偶尔牙龈出血。她的凝血功能检查结果显示她患有格兰兹曼血栓形成症。如果能确保早期诊断和适当治疗,这种罕见疾病的预后会很好。 Delta Med Col J. Jan 2021;9(2):101-103
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引用次数: 0
Comparative Efficacy of Seed Extract of Tamarindus indica and Vitamin E on the Liver Weight of Long Evan’s Rats Intoxicated with Paracetamol 罗望子种子提取物和维生素 E 对扑热息痛毒性龙艾文大鼠肝脏重量的功效比较
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74870
Nasrin Jahan Shammi, Md Ismail Khan, Zubaida Khatoon Choudhury, Muazzem Hossain, Nashid Sultana, Mst Nadira Parvin, Md Mojib Uddin
Background: Tamarindus indica is an antioxidant rich plant. It has therapeutic interest in drugs and xenobiotics induced liver damage.Objective: This study was aimed to explore the effectiveness of ethanolic extract of seed of Tamarindus indica on liver weight when liver is intoxicated with paracetamol and to compare it with the effects of Vitamin E, a known hepatoprotectant. Materials and method: A total of twenty four Long Evan’s rats were collected and divided into four groups. Each group having sixrats (n=6). Control group received normal diet ad libitum, only paracetamol group received paracetamol (1500 mg/kg) for 12 days and rest two groups received paracetamol (1500 mg/kg) along with ethanolic extract of seed of Tamarindus indica (1250 mg/kg) and vitamin E (500 mg/kg) for 12 days respectively. On 13th day, all rats were sacrificed. Then livers were collected and weighed by an electronic balance.Results: In this study, the mean (±SD) liver weight was 4.08±0.23 in control group, 6.27±0.68 in only paracetamol treated group, 5.22±0.72 and 4.57±0.86 in paracetamol along with seed extract of Tamarindus indica and vitamin E treated group respectively.Conclusion: The present study showed that mean (±SD) weight of liver increased with paracetamol and decreased with seed extract of Tamarindus indica which is similar to the effects of vitamin E.   Delta Med Col J. Jan 2021;9(2): 80-83
背景介绍罗望子是一种富含抗氧化剂的植物。目的:本研究旨在探讨罗望子种子乙醇提取物对对乙酰氨基酚中毒的肝脏重量的影响:本研究旨在探讨罗望子种子乙醇提取物对扑热息痛中毒肝脏重量的影响,并将其与维生素 E(一种已知的肝脏保护剂)的作用进行比较。材料和方法收集二十四只 Long Evan 大鼠并将其分为四组。每组六只(n=6)。对照组自由摄入正常饮食,仅扑热息痛组连续 12 天摄入扑热息痛(1500 毫克/千克),其余两组分别连续 12 天摄入扑热息痛(1500 毫克/千克)以及罗望子种子乙醇提取物(1250 毫克/千克)和维生素 E(500 毫克/千克)。第 13 天,所有大鼠被处死。然后收集肝脏并用电子天平称重:结果:在本研究中,对照组大鼠肝脏重量的平均值(±SD)为 4.08±0.23,仅扑热息痛治疗组大鼠肝脏重量的平均值(±SD)为 6.27±0.68,扑热息痛与罗望子种子提取物和维生素 E 治疗组大鼠肝脏重量的平均值(±SD)分别为 5.22±0.72 和 4.57±0.86:本研究表明,对乙酰氨基酚可增加肝脏的平均(±SD)重量,而罗望子种子提取物可减少肝脏的平均(±SD)重量,这与维生素 E 的效果相似。 Delta Med Col J. Jan 2021;9(2):80-83
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引用次数: 0
The Role of Transvaginal Ultrasonography in the Evaluation of Postmenopausal Bleeding 经阴道超声波检查在绝经后出血评估中的作用
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74872
-. Maherunnessa, S. Shermin, Shahnaz Rahman, N. Naher, Mehbuba Jahan
Background: Endometrial cancer is currently the most common malignancy of the female genital tract. Most of the women with endometrial cancer initially present with postmenopausal bleeding (PMB) and may be assessed initially with either endometrial biopsy or transvaginal ultrasonography.Objective: The objective of this study was to evaluate transvaginal ultrasound (TVS) measurement of endometrial thickness (ET) in diagnosing endometrial cancer in women with postmenopausal bleeding.Materials and method: This was a prospective study. Transvaginal ultrasonography and Papanicolaou smear were performed in 291 women presenting with postmenopausal bleeding aged >50 years and were followed up for one year in BIRDEM General Hospital from September 2017 to August 2018.Results: One hundred and seventeen women had an endometrial thickness ≤4 mm and one endometrial cancer (0.85%) was diagnosed in this group. Endometrial biopsy was performed in women who had recurrent bleeding. But in women with an endometrial thickness of ≥5mm (174 out of 291 women), endometrial cancer was diagnosed in 9.77%, atypical hyperplasia in 5.17%, ovarian malignancy in 1.72% and total malignancy was 17.8%.Conclusion: Transvaginal ultrasonography using a ≤4 mm cut-off has high sensitivity for detecting endometrial cancer and can identify women with PMB who are highly unlikely to have endometrial cancer, thereby avoiding more invasive endometrial biopsy.Delta Med Col J. Jan 2021;9(2): 91-95 
背景:子宫内膜癌是目前女性生殖道最常见的恶性肿瘤:子宫内膜癌是目前女性生殖道最常见的恶性肿瘤。大多数罹患子宫内膜癌的妇女最初表现为绝经后出血(PMB),可通过子宫内膜活检或经阴道超声检查进行初步评估:本研究旨在评估经阴道超声(TVS)测量子宫内膜厚度(ET)在绝经后出血妇女子宫内膜癌诊断中的应用:这是一项前瞻性研究。2017年9月至2018年8月,BIRDEM综合医院对291名年龄大于50岁的绝经后出血妇女进行了经阴道超声检查和巴氏涂片检查,并随访一年:117名妇女的子宫内膜厚度≤4毫米,其中1名妇女被诊断为子宫内膜癌(0.85%)。对反复出血的妇女进行了子宫内膜活检。但在子宫内膜厚度≥5 毫米的妇女(291 名妇女中有 174 名)中,9.77%确诊为子宫内膜癌,5.17%为非典型增生,1.72%为卵巢恶性肿瘤,总恶性肿瘤率为 17.8%:结论:经阴道超声波检查以≤4毫米为临界值,对检测子宫内膜癌具有较高的灵敏度,可识别出极不可能患有子宫内膜癌的PMB妇女,从而避免更具侵袭性的子宫内膜活检:91-95
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引用次数: 68
Treatment Related Factors Associated with Non-adherence to Anti-Tuberculosis Treatment 与不坚持抗结核治疗有关的治疗相关因素
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74873
Md Motahar Hossain, M. Flora, Md Saydur Rahman, Md Nurul Amin, Murshida Mosharref, F. Zafreen
Background: Non-adherence to anti-tuberculosis treatment may result in persistent infectiousness on the part of the patient and a higher rate of treatment failure, relapse and drug resistance and therefore, is a significant barrier to the success in tuberculosis control.Objective: To determine the treatment related factors associated with non-adherence to anti-tuberculosis treatment among tuberculosis patients. Materials and method: This case control study was carried out among purposively selected 47tuberculosis patients non-adherent to treatment (cases) and 94 tuberculosis patients adherent to treatment (controls) and were interviewed with a semi-structured questionnaire and checklist in selected DOTS centres of Dhaka city.Results: Statistical analysis shows that, factors like delay in seeking tuberculosis treatment for >6 weeks (OR=4.57; 95% CI, 1.48-14.1) and getting medicine weekly once (OR=2.8; 95% CI, 1.13-6.77) were more likely to be associated with non-adherence to treatment. Lessfrequent visit by health providers (p=0.02), no support for side effect (p=0.042) and non-observation of medication (p=0.009) were also found significant. The reasons behind missing anti-TB doses among non-adherent cases were due to feeling better (53.2%), personal reason (25.5%), feeling worse (19.1%) and forgot to take medicine (2.2%).Conclusion: Mass awareness among the tuberculosis patients is required to improve attitude towards anti-tuberculosis treatment and activities of tuberculosis control programme require further strengthening especially in targeting the patients of low economic status.Delta Med Col J. Jan 2021;9(2): 96-100   
背景:不坚持抗结核治疗可能会导致患者持续感染,提高治疗失败率、复发率和耐药率,因此是成功控制结核病的重要障碍:确定与肺结核患者不坚持抗结核治疗有关的治疗相关因素。材料和方法:这项病例对照研究在达卡市选定的短期直接观察治疗中心有目的性地选择了 47 名不坚持治疗的肺结核患者(病例)和 94 名坚持治疗的肺结核患者(对照组),并通过半结构化问卷和核对表对他们进行了访谈:统计分析表明,结核病治疗延迟超过 6 周(OR=4.57;95% CI,1.48-14.1)和每周服药一次(OR=2.8;95% CI,1.13-6.77)等因素更有可能与不坚持治疗有关。医疗服务提供者很少来访(P=0.02)、副作用得不到支持(P=0.042)和不观察用药情况(P=0.009)也与不坚持治疗有显著关系。在未坚持服药的病例中,漏服抗结核药物的原因包括感觉好些了(53.2%)、个人原因(25.5%)、感觉更糟(19.1%)和忘记服药(2.2%):结论:需要提高结核病患者的大众意识,以改善他们对抗结核治疗的态度,同时需要进一步加强结核病控制计划的活动,尤其是针对经济状况较差的患者:96-100
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引用次数: 0
Autism Spectrum Disorder (ASD) 自闭症谱系障碍(ASD)
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74864
Ruma Sen Gupta
Abstract not availableDelta Med Col J. Jan 2021;9(2): 63-64
摘要不详Delta Med Col J. Jan 2021;9(2):63-64
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引用次数: 0
Clinical Presentation and Outcome of Patients Presented with Acute Confusional State (ACS) in a Tertiary Care Hospital of Bangladesh 孟加拉国一家三级医院急性意识模糊(ACS)患者的临床表现和治疗结果
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74869
Mehjabeen Tasnuva Aslam, Sadia Islam, S. B. Kalam, Dr. Mehjabeen Tasnuva
Background: Acute confusional state (ACS) or delirium is a clinical condition categorized by troubled consciousness, cognitive function, or perception. The key to the management of cases of ACS lies in recognizing a cause or other contributing illness and alleviating it.Objective: To evaluate the patients of ACS intending to identify the clinical presentation of the ACS along with the outcome evaluation of its prognostic importance.Materials and method: A total of 50 patients of ACS fulfilling the DSM-4 criteria were enrolled purposively. It was a hospital-based cross-sectional type of observational study conducted among adult patients of more than 18 years of age for nine months period in the medicine department of Dhaka Medical College Hospital.Results: The mean age of patients was 63.18±9.8 years. Majority of the patients (66%) were male. Hypertension was the most common (46%) associated condition followed by obesity (22%). Fever was common in the majority of cases (78%) followed by disorientation (64%). Among the patients with cerebrovascular accidents, 70.59% had multiple infarcts and 29.42% showed hemorrhage in CT scans of the brain. Most of the patient's (76%) recovery was without any sequelae. Only 6% of patients died during the hospital stay.Conclusion: Acute confusional state (ACS) is among the most common problems in general medicine. Hence, treatment and further workup should run parallel to avoid the morbidity and mortality related to these circumstances.  Delta Med Col J. Jan 2021;9(2): 75-79
背景:急性意识模糊状态(ACS)或谵妄是一种以意识、认知功能或知觉障碍为特征的临床症状。处理 ACS 病例的关键在于识别病因或其他致病因素,并加以缓解:对 ACS 患者进行评估,以确定 ACS 的临床表现及其预后重要性的结果评估:材料和方法:有目的性地招募了50名符合DSM-4标准的ACS患者。这是一项基于医院的横断面观察研究,研究对象是达卡医学院附属医院内科的 18 岁以上成年患者,为期 9 个月:患者的平均年龄为(63.18±9.8)岁。大多数患者(66%)为男性。高血压是最常见的相关疾病(46%),其次是肥胖(22%)。大多数病例(78%)常见发热,其次是神志不清(64%)。在脑血管意外患者中,70.59%患有多发性脑梗塞,29.42%在脑部CT扫描中显示出血。大多数患者(76%)康复后没有留下任何后遗症。只有6%的患者在住院期间死亡:急性意识模糊状态(ACS)是全科医学中最常见的问题之一。因此,治疗和进一步检查应同时进行,以避免与这些情况相关的发病率和死亡率。 Delta Med Col J. Jan 2021;9(2):75-79
{"title":"Clinical Presentation and Outcome of Patients Presented with Acute Confusional State (ACS) in a Tertiary Care Hospital of Bangladesh","authors":"Mehjabeen Tasnuva Aslam, Sadia Islam, S. B. Kalam, Dr. Mehjabeen Tasnuva","doi":"10.3329/dmcj.v9i2.74869","DOIUrl":"https://doi.org/10.3329/dmcj.v9i2.74869","url":null,"abstract":"Background: Acute confusional state (ACS) or delirium is a clinical condition categorized by troubled consciousness, cognitive function, or perception. The key to the management of cases of ACS lies in recognizing a cause or other contributing illness and alleviating it.\u0000Objective: To evaluate the patients of ACS intending to identify the clinical presentation of the ACS along with the outcome evaluation of its prognostic importance.\u0000Materials and method: A total of 50 patients of ACS fulfilling the DSM-4 criteria were enrolled purposively. It was a hospital-based cross-sectional type of observational study conducted among adult patients of more than 18 years of age for nine months period in the medicine department of Dhaka Medical College Hospital.\u0000Results: The mean age of patients was 63.18±9.8 years. Majority of the patients (66%) were male. Hypertension was the most common (46%) associated condition followed by obesity (22%). Fever was common in the majority of cases (78%) followed by disorientation (64%). Among the patients with cerebrovascular accidents, 70.59% had multiple infarcts and 29.42% showed hemorrhage in CT scans of the brain. Most of the patient's (76%) recovery was without any sequelae. Only 6% of patients died during the hospital stay.\u0000Conclusion: Acute confusional state (ACS) is among the most common problems in general medicine. Hence, treatment and further workup should run parallel to avoid the morbidity and mortality related to these circumstances.  \u0000Delta Med Col J. Jan 2021;9(2): 75-79","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141650103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefits and Challenges of Online Teaching Learning from the Students’ View 从学生角度看在线教学的优势和挑战
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74868
Rayhana Sultana, Rono Mollika, Afroza Khanam Sumy, S. Shahjamal, Farzana Alam, Pran Ashraf
Background: Online learning is the major concept in education which converts the traditional educational shape into a new form that transforms in person or physical learning into a virtual approach of learning. It is an alternative to traditional classroom learning and involves using primarily the internet and one or more other technologies.Objective: This study explores the perception of students regarding its benefits and challenges and recommendations.Materials and method: Data were collected from 273 students of 1st and 2nd year MBBS from January 2021 to February 2021 at Enam Medical College, Savar, Dhaka, Bangladesh, using a predesigned validated questionnaire.Results: The findings of the present study revealed that most of the students lack in academic or institutional knowledge regarding the ICT tools used in online learning process. The benefits included its flexibility regarding the time and place, sharing of information is easy and cost effective and allows mass audiences. Whereas, less effective in practice-based learning, instant feedback is difficult, lack of attentiveness, disturbance of physical health and diminished social interaction were identified as major disadvantagesConclusion: Online learning has its own set of advantages and disadvantages as other teaching methods. The purpose of this study was to assess the current state of online learning activities from the students’ perspective.  Delta Med Col J. Jan 2021;9(2): 69-74
背景:在线学习是教育领域的一个重要概念,它将传统的教育形式转变为一种新的形式,将面对面或实体的学习转变为一种虚拟的学习方式。它是传统课堂学习的替代方式,主要涉及使用互联网和一种或多种其他技术:本研究探讨了学生对其益处、挑战和建议的看法:采用预先设计的有效问卷,从 2021 年 1 月至 2021 年 2 月在孟加拉国达卡萨瓦尔市伊南医学院医学学士学位一年级和二年级的 273 名学生中收集数据:本研究结果表明,大多数学生缺乏有关在线学习过程中使用的信息和通信技术工具的学术或机构知识。在线学习的好处包括时间和地点灵活,信息共享方便,成本效益高,受众面广。结论:在线学习有其自身的优势,但也有其不足之处:结论:在线学习与其他教学方法一样,各有利弊。本研究旨在从学生的角度评估在线学习活动的现状。 Delta Med Col J. Jan 2021;9(2):69-74
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引用次数: 0
Role of Adding Topical Metronidazole in the Treatment of Acute Anal Fissure 局部外用甲硝唑在治疗急性肛裂中的作用
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74871
Shayda Ali, Fouzia Sultana, Russel Ahmed Khan Lodi, Tapesh Kumar Paul, Khaleda Nazneen Bari
Background: An anal fissure is a longitudinal ulcer in the anoderm of the distal anal canal which extends from the anal verge proximally towards, but not beyond, the dentate line. Anal fissure is a disease characterized by severe pain in the anorectal region with constipation, per rectal bleeding and sometime itching. Recently, anaerobic bacteria are sorted out as a causative factor.Objective: This study investigates patient compliance in the treatment of anal fissure with adding topical metronidazole. Materials and method: A total number of 100 patients attended to the General Surgery Clinic of Delta Medical College Hospital, Department of Surgery, between December 2020 and May 2021 and diagnosed with acute anal fissure were included in this prospective study. Patients older than 18 years, including non-pregnant, pregnant and lactating women are recruited. Patients were randomly divided in two groups. One group (group: 1) was treated with topical glyceryl trinitrate [0.4% nitroglycerin ointment], and the other group (group: 2) was treated with topical glyceryl trinitrate [0.4% nitroglycerin ointment] and topical antibiotic [metronidazole 0.75%].Results: There is no difference between the groups regarding age and symptoms. From week 1, fissure healing rates were high in group 2. Group 2 VAS score levels were lower than group 1 and achieved by group 1 only in week 4. Compliance of pregnant and lactating lady was more in group 2.Conclusion: Adding topical metronidazole to treatment of acute anal fissure reduces the duration and severity of pain, shortens healing time and increases the healing rate.  Delta Med Col J. Jan 2021;9(2): 84-90
背景:肛裂是肛管远端肛门真皮的纵向溃疡,从肛门边缘向近端延伸至齿状线,但不超过齿状线。肛裂是一种以肛门直肠部位剧烈疼痛、便秘、直肠周围出血和有时瘙痒为特征的疾病。最近,厌氧菌被认为是致病因素之一:本研究调查了患者对外用甲硝唑治疗肛裂的依从性。材料和方法:在 2020 年 12 月至 2021 年 5 月期间,德尔塔医学院附属医院外科学系普通外科门诊共收治了 100 名确诊为急性肛裂的患者。研究对象为 18 岁以上的患者,包括非孕妇、孕妇和哺乳期妇女。患者被随机分为两组。一组(第 1 组)外用硝酸甘油三硝酸酯[0.4% 硝酸甘油软膏],另一组(第 2 组)外用硝酸甘油三硝酸酯[0.4% 硝酸甘油软膏]和外用抗生素[甲硝唑 0.75%]:两组患者在年龄和症状方面没有差异。第 2 组的 VAS 评分低于第 1 组,第 1 组在第 4 周才达到 VAS 评分标准。第 2 组孕妇和哺乳期妇女的依从性更高:结论:在治疗急性肛裂时外用甲硝唑可减少疼痛的持续时间和严重程度,缩短愈合时间并提高愈合率。 Delta Med Col J. Jan 2021;9(2):84-90
{"title":"Role of Adding Topical Metronidazole in the Treatment of Acute Anal Fissure","authors":"Shayda Ali, Fouzia Sultana, Russel Ahmed Khan Lodi, Tapesh Kumar Paul, Khaleda Nazneen Bari","doi":"10.3329/dmcj.v9i2.74871","DOIUrl":"https://doi.org/10.3329/dmcj.v9i2.74871","url":null,"abstract":"Background: An anal fissure is a longitudinal ulcer in the anoderm of the distal anal canal which extends from the anal verge proximally towards, but not beyond, the dentate line. Anal fissure is a disease characterized by severe pain in the anorectal region with constipation, per rectal bleeding and sometime itching. Recently, anaerobic bacteria are sorted out as a causative factor.\u0000Objective: This study investigates patient compliance in the treatment of anal fissure with adding topical metronidazole. Materials and method: A total number of 100 patients attended to the General Surgery Clinic of Delta Medical College Hospital, Department of Surgery, between December 2020 and May 2021 and diagnosed with acute anal fissure were included in this prospective study. Patients older than 18 years, including non-pregnant, pregnant and lactating women are recruited. Patients were randomly divided in two groups. One group (group: 1) was treated with topical glyceryl trinitrate [0.4% nitroglycerin ointment], and the other group (group: 2) was treated with topical glyceryl trinitrate [0.4% nitroglycerin ointment] and topical antibiotic [metronidazole 0.75%].\u0000Results: There is no difference between the groups regarding age and symptoms. From week 1, fissure healing rates were high in group 2. Group 2 VAS score levels were lower than group 1 and achieved by group 1 only in week 4. Compliance of pregnant and lactating lady was more in group 2.\u0000Conclusion: Adding topical metronidazole to treatment of acute anal fissure reduces the duration and severity of pain, shortens healing time and increases the healing rate.  \u0000Delta Med Col J. Jan 2021;9(2): 84-90","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALT in Preeclampsia 子痫前期的谷丙转氨酶
Pub Date : 2024-07-14 DOI: 10.3329/dmcj.v9i2.74867
Razia Sultana, Selina Ahmed, Nasima Sultana, F. Diba
Background: Preeclampsia is the most frequent cause of abnormal liver function test in pregnancy. Women with preeclampsia and raised serum alanine aminotransferase (ALT) have chance of greater proteinuria and more maternal complications than those with normal liver function.Objective: The present study was designed to assess the association of serum ALT with preeclampsia. Materials and method: A case control study was conducted in the Department of Biochemistry, Dhaka Medical College,Dhaka, Bangladesh, from July 2010 to June 2011. From the pregnant women in third trimester of pregnancy attending in Obstetrics and Gynecology Department of Dhaka Medical College Hospital, 50 diagnosed cases of preeclampsia were selected purposively as cases and 50 normal healthy pregnant women as controls. Serum ALT concentration was measured in all the study subjects.Results: The mean serum ALT concentration in cases and controls were 57.92±20.99 U/L and 15.46±2.66 U/L respectively. The level was significantly higher in cases than that of controls (p=0.001).Conclusion: The study revealed that increased serum ALT concentration is associated with preeclampsia. Delta Med Col J. Jan 2021;9(2): 65-68
背景:子痫前期是导致妊娠期肝功能检测异常的最常见原因。与肝功能正常的妇女相比,患有子痫前期且血清丙氨酸氨基转移酶(ALT)升高的妇女有可能出现更多的蛋白尿和更多的孕产并发症:本研究旨在评估血清 ALT 与子痫前期的关系。材料和方法:2010 年 7 月至 2011 年 6 月,孟加拉国达卡医学院生物化学系开展了一项病例对照研究。从达卡医学院附属医院妇产科就诊的怀孕三个月的孕妇中,有目的性地选择 50 例确诊为子痫前期的孕妇作为病例,50 例正常健康孕妇作为对照。对所有研究对象的血清 ALT 浓度进行了测量:结果:病例和对照组的平均血清 ALT 浓度分别为 57.92±20.99 U/L和 15.46±2.66 U/L。病例的水平明显高于对照组(P=0.001):研究显示,血清ALT浓度升高与子痫前期有关。Delta Med Col J. Jan 2021;9(2):65-68
{"title":"ALT in Preeclampsia","authors":"Razia Sultana, Selina Ahmed, Nasima Sultana, F. Diba","doi":"10.3329/dmcj.v9i2.74867","DOIUrl":"https://doi.org/10.3329/dmcj.v9i2.74867","url":null,"abstract":"Background: Preeclampsia is the most frequent cause of abnormal liver function test in pregnancy. Women with preeclampsia and raised serum alanine aminotransferase (ALT) have chance of greater proteinuria and more maternal complications than those with normal liver function.\u0000Objective: The present study was designed to assess the association of serum ALT with preeclampsia. Materials and method: A case control study was conducted in the Department of Biochemistry, Dhaka Medical College,Dhaka, Bangladesh, from July 2010 to June 2011. From the pregnant women in third trimester of pregnancy attending in Obstetrics and Gynecology Department of Dhaka Medical College Hospital, 50 diagnosed cases of preeclampsia were selected purposively as cases and 50 normal healthy pregnant women as controls. Serum ALT concentration was measured in all the study subjects.\u0000Results: The mean serum ALT concentration in cases and controls were 57.92±20.99 U/L and 15.46±2.66 U/L respectively. The level was significantly higher in cases than that of controls (p=0.001).\u0000Conclusion: The study revealed that increased serum ALT concentration is associated with preeclampsia. \u0000Delta Med Col J. Jan 2021;9(2): 65-68","PeriodicalId":53280,"journal":{"name":"Delta Medical College Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141650500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic Features and Outcome of COVID-19 Patients Attended at a Secondary Hospital in Bangladesh during the Pandemic 大流行期间在孟加拉国一家二级医院就诊的 COVID-19 患者的临床病理特征和治疗结果
Pub Date : 2024-02-07 DOI: 10.3329/dmcj.v9i1.71330
Syed Mohammad Shaifuddin, Md Abdul Wahab, F. Zafreen, Jaida Jalal Sarker
Background: Coronavirus Disease 2019 (COVID-19) is an acute respiratory diseasethat can present varieties of clinical and pathologic manifestation. Sometimes it presentwith severe manifestation which ultimately lead to respiratory failure and death.COVID-19 patients with other comorbidities may develop a life-threatening situation.Objective: To describe the clinicopathologic features and outcome of COVID-19patients admitted in Combined Military Hospital (CMH) Rangpur, Bangladesh.Materials and method: This cross-sectional study was conducted at CMH Rangpur,Bangladesh, from 1 May 2021 to 30 August 2021 among purposively selected 416 casesof COVID-19 positive patients. Data were collected from the medical records of thehospital admitted patients in a structured case report form. Results: Highest numbers ofthe respondents were in the age group of 31-50 years (49.03%) with male predominance(72.28%). About 89% were Muslim and 54.81% were educated up to higher secondarylevel. Fever (90.86%) was the common presenting symptoms followed by cough(73.55%), sore throat (30.28%). About 24.51%, 23.07%, 11.05% had hypertension,diabetes mellitus and respiratory comorbidities respectively. Lymphopenia (75.24%)and elevated C-Reactive Protein (54.08%) were observed in most of the cases. Only8.17% patients had critical illness that needed intensive care unit admission. Majority(91.82%) fully recovered from the illness while 1.92% expired. Conclusions: The mostcommonly reported symptom was fever (90.86%) among all the COVID-19 positivepatients. Majority (62.25%) of the patients belonged to mild cases. Overall mortalitywas 1.92%. In most cases the clinical presentation is that of a respiratory infection withsymptom severity ranging from a mild influenza like illness. Delta Med Col J. Jan 2021;9(1):3-8
背景:冠状病毒病2019(COVID-19)是一种急性呼吸道疾病,可出现多种临床和病理表现。COVID-19患者如果合并其他疾病,可能会危及生命:描述孟加拉国兰布尔联合军事医院(CMH)收治的COVID-19患者的临床病理特征和预后:这项横断面研究于 2021 年 5 月 1 日至 2021 年 8 月 30 日在孟加拉国兰布尔联合军事医院(CMH Rangpur)进行,研究对象是有目的性地选择的 416 例 COVID-19 阳性患者。数据通过结构化病例报告表从入院患者的病历中收集。研究结果31-50岁年龄段的受访者人数最多(49.03%),男性占多数(72.28%)。约 89% 的受访者为穆斯林,54.81% 的受访者受过高中以上教育。发热(90.86%)是常见的症状,其次是咳嗽(73.55%)和咽喉痛(30.28%)。分别约有 24.51%、23.07% 和 11.05% 的人患有高血压、糖尿病和呼吸系统合并症。大多数病例出现淋巴细胞减少(75.24%)和 C 反应蛋白升高(54.08%)。只有 8.17% 的患者病情危重,需要入住重症监护室。大多数患者(91.82%)完全康复,1.92%的患者死亡。结论在所有 COVID-19 阳性患者中,最常见的症状是发热(90.86%)。大多数患者(62.25%)属于轻度病例。总死亡率为 1.92%。在大多数病例中,临床表现为呼吸道感染,症状严重程度从轻微的类似流感的疾病到严重的呼吸道感染。三角洲医学杂志》,2021 年 1 月;9(1):3-8
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引用次数: 0
期刊
Delta Medical College Journal
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