{"title":"Understanding the Genotypes and Phenotypes Relationship: Progress toward a Precision Medicine Approach in Pediatric Pulmonary Hypertension","authors":"K. Lun","doi":"10.55503/2790-6744.1474","DOIUrl":"https://doi.org/10.55503/2790-6744.1474","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47906361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhuoyuan Xu, Hongsheng Zhang, Chen Zhang, Qiangqiang Li, H. Gu
{"title":"Clinical Features and Prognosis of Chinese Childhood Pulmonary Arterial Hypertension-Related Gene Mutation Carriers","authors":"Zhuoyuan Xu, Hongsheng Zhang, Chen Zhang, Qiangqiang Li, H. Gu","doi":"10.55503/2790-6744.1475","DOIUrl":"https://doi.org/10.55503/2790-6744.1475","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47934561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The value of 3D vena contracta area in a patient with degenerative mitral regurgitation and multiple jets","authors":"S. Ching, C. Yue","doi":"10.55503/2790-6744.1202","DOIUrl":"https://doi.org/10.55503/2790-6744.1202","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43929277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Li, Y. Tse, Cong Chen, Sijia Cai, Meng-Qi Su, Mei-Zhen Wu, Q. Ren, Jiayi Huang, Siyun Yu, Y. Chan, H. Tse, K. Yiu
{"title":"Epidemiology and Characteristics of Surgical Intervention for Infective Endocarditis: A Population-Based Study in the Past Two Decades (2000 – 2019) in Hong Kong","authors":"H. Li, Y. Tse, Cong Chen, Sijia Cai, Meng-Qi Su, Mei-Zhen Wu, Q. Ren, Jiayi Huang, Siyun Yu, Y. Chan, H. Tse, K. Yiu","doi":"10.55503/2790-6744.1485","DOIUrl":"https://doi.org/10.55503/2790-6744.1485","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43608269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indicators of Cardiac Autonomic Dysfunction Associated with Chronic Hyperglycemia: Implications on Vascular Surrogates and Heart Failure","authors":"Y. Chan, B. Cheung, H. Tse","doi":"10.55503/2790-6744.1487","DOIUrl":"https://doi.org/10.55503/2790-6744.1487","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49259463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Lam, J. Wong, Chun-Ka Wong, G. Kwok, Ming Zhou, Benjamin Y F So, I. Leung, H. Tse
{"title":"From Bad to Worse: The Clinical Spectrum of Immune Checkpoint Inhibitor Myocarditis and Associated 3M Syndrome with Concomitant Myositis and Myasthenia","authors":"T. Lam, J. Wong, Chun-Ka Wong, G. Kwok, Ming Zhou, Benjamin Y F So, I. Leung, H. Tse","doi":"10.55503/2790-6744.1484","DOIUrl":"https://doi.org/10.55503/2790-6744.1484","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45064251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes mellitus. However, little is known on changes in smooth muscle contractility and the intracellular mechanisms contributing to such altered responsiveness in blood vessels from diabetic patients. Thus, smooth muscle reactivity to increased K + , norepinephrine (NE) and phenylephrine (PE) and acetylcholine-induced endothelium-dependent relaxation were assessed in uterine arteries from control individuals (CI) and diabetic patients (DM). Smooth muscle sensitivity to K + , NE and PE was enhanced by 1.4, 2.3-and 9.7-fold and relaxation was reduced by 64% in vessels from DM. In addition, in freshly isolated smooth muscle cells from DM an increased perinuclear Ca 2+ signaling to K + (30 mmol/l: +73%; 30 mmol/l: +68%) and NE (300 nmol/l +86%; 10 mol/l +67%) was found, which promotes smooth muscle contraction. In contrast, subplasmalemmal Ca 2+ response, which favors smooth muscle relaxation due to activation of Ca 2+ -activated K + channels, was reduced by 38% in DM, indicating a significant change in the subcellular Ca 2+ distribution in vascular smooth muscle cells during diabetes. In contrast to the altered Ca 2+ signaling found in freshly isolated cells from DM, in cultured smooth muscle cells isolated from CI and DM no further difference in the Ca 2+ signaling to stimulation with either K + or NE was found. Hence, production of superoxide anions (ïO 2) in intact and endothelium-denuded arteries from DM was increased by 150 and 136%, respectively. Incubation of freshly isolated smooth muscle cells from CI with
{"title":"ICSM 3rd Annual Scientific Meeting Plenary Lectures","authors":"PLenAry LeCTureS, W. F. Graier","doi":"10.55503/2790-6744.1472","DOIUrl":"https://doi.org/10.55503/2790-6744.1472","url":null,"abstract":"Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes mellitus. However, little is known on changes in smooth muscle contractility and the intracellular mechanisms contributing to such altered responsiveness in blood vessels from diabetic patients. Thus, smooth muscle reactivity to increased K + , norepinephrine (NE) and phenylephrine (PE) and acetylcholine-induced endothelium-dependent relaxation were assessed in uterine arteries from control individuals (CI) and diabetic patients (DM). Smooth muscle sensitivity to K + , NE and PE was enhanced by 1.4, 2.3-and 9.7-fold and relaxation was reduced by 64% in vessels from DM. In addition, in freshly isolated smooth muscle cells from DM an increased perinuclear Ca 2+ signaling to K + (30 mmol/l: +73%; 30 mmol/l: +68%) and NE (300 nmol/l +86%; 10 mol/l +67%) was found, which promotes smooth muscle contraction. In contrast, subplasmalemmal Ca 2+ response, which favors smooth muscle relaxation due to activation of Ca 2+ -activated K + channels, was reduced by 38% in DM, indicating a significant change in the subcellular Ca 2+ distribution in vascular smooth muscle cells during diabetes. In contrast to the altered Ca 2+ signaling found in freshly isolated cells from DM, in cultured smooth muscle cells isolated from CI and DM no further difference in the Ca 2+ signaling to stimulation with either K + or NE was found. Hence, production of superoxide anions (ïO 2) in intact and endothelium-denuded arteries from DM was increased by 150 and 136%, respectively. Incubation of freshly isolated smooth muscle cells from CI with","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41964750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ECG QUIZ","authors":"N. Mok, P. Tsui, Chee-Wo Wu","doi":"10.55503/2790-6744.1467","DOIUrl":"https://doi.org/10.55503/2790-6744.1467","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41516719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of 18-lead Electrocardiogram in Diagnosing Right Ventricular and Posterior Wall Involvement in Patients with Acute Inferior Myocardial Infarction","authors":"C. Yue, Wai‐Kwong Chan","doi":"10.55503/2790-6744.1464","DOIUrl":"https://doi.org/10.55503/2790-6744.1464","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41856402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3rd Annual Scientific Meeting Abstracts for Poster Presentation","authors":"","doi":"10.55503/2790-6744.1471","DOIUrl":"https://doi.org/10.55503/2790-6744.1471","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47269690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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