{"title":"Early Results of Percutaneous Myocardial Revascularization with Three Dimensional Non-fluoroscopic Electromechanical Mapping - A Novel Revascularization Therapy in Patients with End Stage Coronary Artery Disease","authors":"Pui-yin Lee, C. Lau, D. Ho, H. Tse","doi":"10.55503/2790-6744.1388","DOIUrl":"https://doi.org/10.55503/2790-6744.1388","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47828699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3rd Annual Scientific Meeting Front Matter","authors":"","doi":"10.55503/2790-6744.1395","DOIUrl":"https://doi.org/10.55503/2790-6744.1395","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46294270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3rd Annual Scientific Meeting Scientific Programme","authors":"","doi":"10.55503/2790-6744.1397","DOIUrl":"https://doi.org/10.55503/2790-6744.1397","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49669685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blood Coagulation and Heart Disease","authors":"Y. Kwong","doi":"10.55503/2790-6744.1384","DOIUrl":"https://doi.org/10.55503/2790-6744.1384","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45941400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CHEN AND LAU : Recent Advances in Antithrombin Therapy for Acute Coronary Syndromes. Unstable angina and acute myocardial infarction are leading causes of hospital admissions worldwide. Following the initiating event of atherosclerotic plaque rupture, activation of the coagulation cascade plays an important role in mediating local thrombosis. Novel antithrombotic agents have recently been developed and applied in clinical practice. The direct antithrombins have the advantage of inhibiting both fluid-phase and clot-bound thrombin. Despite a sound theoretical basis, the prototypical agent hirudin has been demonstrated to be only equivalent to unfractionated heparin as adjunctive therapy to thrombolysis in ST-elevation myocardial infarction. Although showing a better efficacy than unfractionated heparin in unstable angina/non-Q wave myocardial infarction, hirudin causes more major bleeding complications. Low-molecular-weight heparins have the advantages of a better bioavailability, longer half-life and dose-independent clearance, making subcutaneous administration possible and monitoring unnecessary. Enoxaparin has been proven to be superior to unfractionated heparin in two large randomised trials of unstable angina/non-Q wave myocardial infarction while equivalence is demonstrated for other low-molecular-weight heparins. A higher anti-Xa:anti-IIa ratio may explain the varying efficacy. In the near future low-molecular-weight heparins and newer antithrombin agents may replace unfractionated heparin in the management of acute coronary syndromes as ongoing clinical trials further define their roles. (J HK Coll Cardiol 1999;7:109-118)
{"title":"Recent Advances in Antithrombin Therapy for Acute Coronary Syndromes","authors":"Wai-hong Chen, C. Lau","doi":"10.55503/2790-6744.1391","DOIUrl":"https://doi.org/10.55503/2790-6744.1391","url":null,"abstract":"CHEN AND LAU : Recent Advances in Antithrombin Therapy for Acute Coronary Syndromes. Unstable angina and acute myocardial infarction are leading causes of hospital admissions worldwide. Following the initiating event of atherosclerotic plaque rupture, activation of the coagulation cascade plays an important role in mediating local thrombosis. Novel antithrombotic agents have recently been developed and applied in clinical practice. The direct antithrombins have the advantage of inhibiting both fluid-phase and clot-bound thrombin. Despite a sound theoretical basis, the prototypical agent hirudin has been demonstrated to be only equivalent to unfractionated heparin as adjunctive therapy to thrombolysis in ST-elevation myocardial infarction. Although showing a better efficacy than unfractionated heparin in unstable angina/non-Q wave myocardial infarction, hirudin causes more major bleeding complications. Low-molecular-weight heparins have the advantages of a better bioavailability, longer half-life and dose-independent clearance, making subcutaneous administration possible and monitoring unnecessary. Enoxaparin has been proven to be superior to unfractionated heparin in two large randomised trials of unstable angina/non-Q wave myocardial infarction while equivalence is demonstrated for other low-molecular-weight heparins. A higher anti-Xa:anti-IIa ratio may explain the varying efficacy. In the near future low-molecular-weight heparins and newer antithrombin agents may replace unfractionated heparin in the management of acute coronary syndromes as ongoing clinical trials further define their roles. (J HK Coll Cardiol 1999;7:109-118)","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46247119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Benishin, Richard Lewanozuk, Jacqueline, Shan
{"title":"3rd Annual Scientific Meeting Abstracts","authors":"Christina Benishin, Richard Lewanozuk, Jacqueline, Shan","doi":"10.55503/2790-6744.1400","DOIUrl":"https://doi.org/10.55503/2790-6744.1400","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45048145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guidelines for the Training and Practice of Percutaneous Coronary Interventions","authors":"","doi":"10.55503/2790-6744.1393","DOIUrl":"https://doi.org/10.55503/2790-6744.1393","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41988391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : The Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly and Drugs/alcohol (HAS-BLED) score is a validated bleeding risk prediction tool in patients with atrial fi brillation taking oral anticoagulation. Its predictive value in patients with atrial fi brillation undergoing percutaneous coronary intervention receiving combination of anticoagulation and antiplatelet therapy is unknown. This retrospective cohort study sought to validate the accuracy of HAS-BLED score in predicting the bleeding risk in patients with atrial fi brillation who underwent percutaneous coronary intervention receiving both anti-coagulation and dual antiplatelet therapy. Method : We calculated HAS-BLED score in 186 patients with AF undergoing coronary stenting and assessed the incidence of bleeding events de fi ned by the International Society on Thrombosis and Hemostasis (ISTH) bleeding scale. Results : The mean age of the patients was 72. The proportion of male to female was 2.93: 1. Using a HAS-BLED cut off of ≥ 3, a signi fi cantly higher incidence of bleeding was detected in the high HAS-BLED compared to the low HAS-BLED cohort. Such difference of bleeding incidence remained signi fi cant in the triple therapy subgroup whereas it became statistically insigni fi cant in the dual-antiplatelet subgroup. The predictive performance was modest (AUC 0.673, 95% CI, 0.535 e 0.811, p ¼ 0.028). Conclusion : HAS-BLED score is a simple and useful tool to predict bleeding risk in a group of atrial fi brillation patients who require triple therapy after percutaneous coronary intervention.
背景：高血压、肾/肝功能异常、中风、出血史或倾向、Labile国际标准化比率、老年人和药物/酒精（HAS-BLED）评分是口服抗凝治疗心房颤动患者的有效出血风险预测工具。它对接受抗凝和抗血小板联合治疗的经皮冠状动脉介入治疗的心房颤动患者的预测价值尚不清楚。这项回顾性队列研究旨在验证HAS-BLED评分在预测接受经皮冠状动脉介入治疗并接受抗凝和双重抗血小板治疗的心房颤动患者出血风险方面的准确性。方法：我们计算了186名接受冠状动脉支架置入术的房颤患者的HAS-BLED评分，并评估了国际血栓与止血学会（ISTH）出血量表定义的出血事件的发生率。结果：患者平均年龄72岁。男女比例为2.93:1。使用≥3的HAS-BLED截距，与低HAS-BLE队列相比，高HAS-BLED队列的出血发生率明显更高。这种出血发生率的差异在三联治疗亚组中仍然显著，而在双抗血小板治疗亚组则变得统计学上不显著。预测性能适中（AUC 0.673，95%CI，0.535 e 0.811，p¼0.028）。结论：HAS-BLED评分是预测一组经皮冠状动脉介入治疗后需要三重治疗的心房颤动患者出血风险的简单而有用的工具。
{"title":"The Utility Of HAS-BLED Score In Predicting The Bleeding Risk Of Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention Receiving Anticoagulation And Dual Anti-platelet Therapy: A Single Center Retrospective Cohort Study","authors":"Luk Yin Cheung Adrian, Chan Chi Lin Jaclyn","doi":"10.55503/2790-6744.1211","DOIUrl":"https://doi.org/10.55503/2790-6744.1211","url":null,"abstract":"Background : The Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly and Drugs/alcohol (HAS-BLED) score is a validated bleeding risk prediction tool in patients with atrial fi brillation taking oral anticoagulation. Its predictive value in patients with atrial fi brillation undergoing percutaneous coronary intervention receiving combination of anticoagulation and antiplatelet therapy is unknown. This retrospective cohort study sought to validate the accuracy of HAS-BLED score in predicting the bleeding risk in patients with atrial fi brillation who underwent percutaneous coronary intervention receiving both anti-coagulation and dual antiplatelet therapy. Method : We calculated HAS-BLED score in 186 patients with AF undergoing coronary stenting and assessed the incidence of bleeding events de fi ned by the International Society on Thrombosis and Hemostasis (ISTH) bleeding scale. Results : The mean age of the patients was 72. The proportion of male to female was 2.93: 1. Using a HAS-BLED cut off of ≥ 3, a signi fi cantly higher incidence of bleeding was detected in the high HAS-BLED compared to the low HAS-BLED cohort. Such difference of bleeding incidence remained signi fi cant in the triple therapy subgroup whereas it became statistically insigni fi cant in the dual-antiplatelet subgroup. The predictive performance was modest (AUC 0.673, 95% CI, 0.535 e 0.811, p ¼ 0.028). Conclusion : HAS-BLED score is a simple and useful tool to predict bleeding risk in a group of atrial fi brillation patients who require triple therapy after percutaneous coronary intervention.","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48990027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tsao, G. Chua, M. Kwan, I. Wong, K. W. To, J. Kwok, Bill H. Chan, J. S. Wong, P. Ip, Y. Lau
{"title":"Cardiac Involvement related to COVID-19 Infection and Vaccination in Children and Adolescents – Hong Kong’s Perspective","authors":"S. Tsao, G. Chua, M. Kwan, I. Wong, K. W. To, J. Kwok, Bill H. Chan, J. S. Wong, P. Ip, Y. Lau","doi":"10.55503/2790-6744.1208","DOIUrl":"https://doi.org/10.55503/2790-6744.1208","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46724590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark Tsz Kin TAM, Anna Kin Yin Chan, Alex Chi Kin Au, Lily Cheung, Gary Chin Pang Chan, Joseph Yat Sun Chan
{"title":"Effect of low body mass index in outcome of Micra leadless pacemaker implantation","authors":"Mark Tsz Kin TAM, Anna Kin Yin Chan, Alex Chi Kin Au, Lily Cheung, Gary Chin Pang Chan, Joseph Yat Sun Chan","doi":"10.55503/2790-6744.1213","DOIUrl":"https://doi.org/10.55503/2790-6744.1213","url":null,"abstract":"","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49290899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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