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Psychometric Properties of the Turkish Version of the Children's Saving Inventory in a Clinical Sample. 土耳其版儿童储蓄量表在临床样本中的心理测量特性。
IF 1.5 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-01 DOI: 10.5152/eurasianjmed.2023.23102
Mehmet Akif Akıncı, Bahadır Turan, Ali Çakır, İbrahim Selçuk Esin, Eric Alan Storch, Onur Burak Dursun

Objective: The Children's Saving Inventory (CSI) is a measurement tool developed to assess hoarding behavior in children. This study aims to investigate the psychometric properties of the Turkish version of the CSI in a clinical sample of children and adolescents.

Materials and methods: The study sample consisted of 52 children and adolescents diagnosed with obsessive-compulsive disorder in the 8-17 age group and their families. As a structured diagnostic interview, the Development and Well-Being Assessment (DAWBA) was applied to all participants included in the research. Hoarding disorder (HD) diagnosis was made clinically by considering the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria. The Children's Yale-Brown Obsessive- Compulsive Scale Symptom Checklist (CY-BOCS) was administered by an experienced clinician. The parents and children filled out the Obsessive-Compulsive Inventory-Child Version (OCI-CV) and CSI scales independently.

Results: The 20-item CSI Turkish version demonstrated good internal consistency. This 4-factor structure of the scale was confirmed by confirmatory factor analysis. Children's Saving Inventory showed convergent and discriminant validity with the OCI-CV and CY-BOCS subscales, and the higher CSI total scores in children and adolescents diagnosed with HD confirmed the construct validity.

Conclusion: These findings support the use of the CSI Turkish version as a valid and reliable scale to investigate the hoarding behavior of children and adolescents in a clinical sample. In addition, the CSI Turkish version is currently the only validated instrument to evaluate hoarding behavior in children and adolescents, as rated by parents in Türkiye.

目的:儿童储蓄量表(CSI)是一种用于评估儿童囤积行为的测量工具。本研究旨在调查土耳其版CSI在儿童和青少年临床样本中的心理测量特性。材料和方法:研究样本包括52名8-17岁年龄段被诊断为强迫症的儿童和青少年及其家人。作为一种结构化的诊断性访谈,发展与幸福感评估(DAWBA)适用于研究中的所有参与者。囤积症(HD)的临床诊断是根据《精神障碍诊断与统计手册》第五版(DSM-5)的诊断标准进行的。儿童耶鲁-布朗强迫症症状量表(CY-BOCS)由一位经验丰富的临床医生进行管理。父母和孩子分别独立填写强迫症儿童量表(OCI-CV)和CSI量表。结果:20项CSI土耳其版显示出良好的内部一致性。该量表的4因素结构通过验证性因素分析得到了证实。儿童储蓄量表在OCI-CV和CY-BOCS分量表中显示出收敛和判别有效性,诊断为HD的儿童和青少年的较高CSI总分证实了结构有效性。结论:这些发现支持使用CSI土耳其版作为一种有效和可靠的量表来调查临床样本中儿童和青少年的囤积行为。此外,CSI土耳其版是目前唯一经验证的评估儿童和青少年囤积行为的工具,由土耳其家长评定。
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引用次数: 0
Superb Microvascular Imaging at Evaluation of Nonvisible Buried De-epitelized Flap Vascularization in Breast Reconstruction. Superb微血管成像在评估乳腺重建中不可见的埋藏式去上皮化皮瓣血管化中的应用。
IF 1.5 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-01 DOI: 10.5152/eurasianjmed.2023.23063
Tuğba Gün Koplay, Emine Uysal, Hande Köksal, İbrahim Babalıoğlu

Objective: Superb microvascular imaging is a Doppler technique that increases the visibility of small vessels and gives quantitative information about tissue blood supply by measuring the vascular index. In this study, it is aimed to evaluate the long-term and postradiotherapy changes in blood flow of buried de-epitelized flaps in breast reconstruction by using the quantitative values obtained through superb microvascular imaging.

Materials and methods: Retrospective review of the 14 patients who underwent nipple-sparing breastconserving surgery and immediately breast reconstruction with a de-epitelized extended latissimus dorsi flap was done. In order to demonstrate the effect of radiotherapy on flaps microvascular circulation, patients were evaluated using superb microvascular imaging postoperative first week, first month, and postradiotherapy first week and sixth month. The normal distribution of the data was evaluated with the Shapiro-Wilk test. Paired samples t-test was used for comparisons.

Results: According to the paired samples t-tests, postoperative first week mean vascular index was higher than postoperative first month and postradiotherapy first week (P < .05). Besides, postradiotherapy first week mean vascular index was higher than postoperative first month and also than postradiotherapy sixth month (P < .05).

Conclusion: Radiotherapy can affect the results of breast reconstruction by endothelial and fibrotic injury. In this study, the changes in the microvascular circulation of the latissimus dorsi flap were discussed and found to increase at postoperative and postradiotherapy early period related to inflammation and not decreased significantly at long-term follow-up after radiotherapy.

目的:超微血管成像是一种多普勒技术,通过测量血管指数来增加小血管的可见性,并提供组织血液供应的定量信息。在本研究中,目的是利用通过极好的微血管成像获得的定量值来评估乳腺重建中埋入式去上皮化皮瓣的长期和放疗后血流量变化。材料和方法:对14例患者进行了回顾性分析,这些患者接受了保留乳头的保乳手术,并立即用去上皮化的延伸背阔肌皮瓣重建乳房。为了证明放疗对皮瓣微血管循环的影响,在术后第一周、第一个月以及放疗后第一周和第六个月,对患者进行了极好的微血管成像评估。数据的正态分布用Shapiro-Wilk检验进行评估。采用配对样本t检验进行比较。结果:根据配对样本t检验,术后第一周平均血管指数高于术后第一个月和放疗后第一周(P<0.05),放疗后第一周平均血管指数高于术后第一个月和放疗后第六个月(P<0.05)。在本研究中,讨论了背阔肌皮瓣微血管循环的变化,发现在术后和放疗后早期与炎症相关的变化增加,而在放疗后的长期随访中没有显著减少。
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引用次数: 0
YouTube Educational Videos for Peripheral Block Learning and Application: A Survey of Turkish Anesthesiologists; How Successful. YouTube外围块学习和应用教育视频:土耳其麻醉师调查;多么成功。
IF 1.5 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-01 DOI: 10.5152/eurasianjmed.2023.23075
Selçuk Alver, Bahadir Ciftci, Birzat Emre Gölboyu, Mohammad Sargolzaeimoghaddam, Cem Erdoğan, Haci Ahmet Alıcı, Ali Ahiskalioglu

Objective: The aims of this survey study were to evaluate the contribution of YouTube to nerve-block learning/education and the advantages and disadvantages of the YouTube.

Materials and methods: A total of 24 questions were selected for the survey by consensus of the authors. Information in the form of web data was obtained through an electronic data form that was distributed via WhatsApp to known email addresses and phone numbers of 300 practitioners (anesthesia residents, anesthesiologists, and academicians). There were a total of 24 questions on the survey. The first section included 5 questions collecting demographic data, and the second part encompassed 19 questions about the YouTube nerve block videos.

Results: Among the participants, 232 of practitioners (86.9%) performed peripheral nerve blocks, and only 35 practitioners (13.1%) had no experience of nerve blocks so and used YouTube videos for educational purposes. According to our results, YouTube videos frequently improved performance. In addition, YouTube improved the training of practitioners in terms of the type of block procedure, identifying anatomical landmarks, target structures like nerves and blood vessels, needle visualization, needle depth, and patient position.

Conclusion: YouTube contributes to the performance of regional anesthesia and to learning at all academic levels. It should not be forgotten that such videos are not peer reviewed by professionals in the relevant field.

目的:本调查研究旨在评估YouTube对神经阻滞学习/教育的贡献以及YouTube的优缺点。材料和方法:经作者协商一致,共选择24个问题进行调查。网络数据形式的信息是通过电子数据表格获得的,该表格通过WhatsApp分发到300名从业者(麻醉住院医师、麻醉师和院士)的已知电子邮件地址和电话号码。调查共有24个问题。第一部分包括5个收集人口统计数据的问题,第二部分包括19个关于YouTube神经阻断视频的问题。结果:在参与者中,232名从业者(86.9%)进行了外周神经阻滞,只有35名从业者(13.1%)没有神经阻滞经验,因此使用YouTube视频进行教育。根据我们的研究结果,YouTube视频经常提高性能。此外,YouTube改进了对从业者的培训,包括阻滞程序类型、识别解剖标志、神经和血管等目标结构、针头可视化、针头深度和患者位置。结论:YouTube有助于区域麻醉的表现和所有学术水平的学习。不应忘记,此类视频未经相关领域专业人士同行评审。
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引用次数: 0
7,8-Dihydroxy Flavone Induces Apoptosis via Upregulation of Caspase-3 in Human Hepatocarcinoma Cell. 7,8-二羟基黄酮通过上调人肝癌细胞中的半胱氨酸蛋白酶-3诱导细胞凋亡。
IF 1.5 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-01 DOI: 10.5152/eurasianjmed.2023.22283
Gülsüm Abuşoğlu, Mukaddes İrem Durmuş, Serdar Karakurt

Objective: 7,8-Dihydroxyflavone, a tyrosine kinase receptor agonist, is a flavonoid that has recently gained the attention of researchers due to its anticancer properties. Nevertheless, molecular pathways of 7,8-dihydroxyflavone for hepatocarcinoma are uncertain. Our aim was to identify the impact of 7,8-dihydroxyflavone on human hepatocarcinoma.

Material and methods: Human hepatocarcinoma cell line-7 cells were used as human hepatocarcinoma cells, and 7,8-dihydroxyflavone was applied to the cells at various doses. The cytotoxic and apoptotic effects of 7,8-dihydroxyflavone were determined with Alamar Blue and flow cytometry. The properties of 7,8-dihydroxyflavone on the mRNA expressions related with Bcl-2, Bax, cleaved-caspase-3 genes, and protein expressions were determined via quantitative real-time polymerase chain reaction and western blot analysis, respectively.

Results: 7,8-Dihydroxyflavone-enhanced cell death in human hepatocarcinoma cell line-7 via the overexpression of cleaved-caspase-3 (P=.003) and decreased Bcl-2 (P=.038) protein levels. Furthermore, cleavedcaspase-3 mRNA overexpression (P=.001) markedly led to 7,8-dihydroxyflavone-induced apoptosis.

Conclusion: 7,8-Dihydroxyflavone could promote apoptotic cell death by modulating caspase pathways and suppressing antiapoptotic protein. These characteristics may mediate to clinical practice of 7,8-dihydroxyflavone for prevention and therapy of hepatocarcinoma.

目的:7,8-二羟基黄酮是一种酪氨酸激酶受体激动剂,近年来因其抗癌特性而受到研究者的关注。然而,7,8-二羟基黄酮治疗肝癌的分子途径尚不确定。我们的目的是确定7,8-二羟基黄酮对人肝癌的影响。材料与方法:以人肝癌细胞系7细胞为材料,采用不同剂量的7,8-二羟基黄酮对细胞进行处理。用Alamar蓝和流式细胞仪测定了7,8-二羟基黄酮的细胞毒性和凋亡作用。通过实时定量聚合酶链反应和蛋白质印迹分析,分别测定了7,8-二羟基黄酮对Bcl-2、Bax、裂解的胱天蛋白酶-3基因相关mRNA表达和蛋白质表达的影响。结果:7,8-二羟基黄酮通过过表达裂解的胱天蛋白酶-3(P=0.003)和降低Bcl-2(P=0.038)蛋白水平,增强了人肝癌细胞系-7的细胞死亡。此外,裂解的半胱氨酸蛋白酶-3 mRNA过表达(P=0.001)显著导致7,8-二羟基黄酮诱导的细胞凋亡。结论:7,8-二羟基黄酮可通过调节caspase通路和抑制抗凋亡蛋白来促进细胞凋亡。这些特征可能介导7,8-二羟基黄酮预防和治疗肝癌的临床实践。
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引用次数: 0
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Eurasian Journal of Medicine
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